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| ○ | Erratum | Correction to: NS1 binding protein regulates stress granule dynamics and clearance by inhibiting p62 ubiquitination (Nature Communications, (2024), 15, 1, (10925), 10.1038/s41467-024-55446-w) | Correction to: Nature Communicationshttps://doi.org/10.1038/s41467-024-55446-w, published online 30 December 2024 In the Acknowledgements section of this article the grant number relating to the Basic research program of the NRF was incorrectly given as 2023R1A2C2008092 and should have been 2023R1A2C2007082. The original article has been corrected. © The Author(s) 2025. | Jeon, Pureum; Ham, Hyun-Ji; Choi, Haneul; Park, Semin; Jang, Jae-Woo; Park, Sang-Won; Cho, Dong-Hyung; Lee, Hyun-Jeong; Song, Hyun Kyu; Komatsu, Masaaki; Han, Dohyun; Jang, Deok-Jin; Lee, Jin-A | Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea; Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea; Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea; Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea; Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea; Department of Ecological Science, College of Ecology and Environment, Kyungpook National University, Sangju, South Korea; School of Life Sciences, BK21 FOUR KNU Creative BioRearch Group, Kyungpook National University, Daegu, 41566, South Korea; Department of Life Sciences, Korea University, Seoul, South Korea; Department of Life Sciences, Korea University, Seoul, South Korea; Department of Physiology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, Japan; Department of Transdiciplinary Medicine, Seoul National University Hospital, Seoul, South Korea, Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Ecological Science, College of Ecology and Environment, Kyungpook National University, Sangju, South Korea; Department of Biological Sciences and Biotechnology, College of Life Sciences and Nanotechnology, Hannam University, Daejeon, South Korea | 57208213892; 57768440400; 57219743631; 57766982600; 57219744861; 57211486702; 58950702200; 59495775200; 7404037299; 7202792529; 7403219960; 22234503100; 35337365000 | leeja@hnu.kr; jangdj@knu.ac.kr; | Nature Communications | NAT COMMUN | N/A | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | drug therapy; erratum; nonhuman; controlled study; diagnosis | English | Final | 2025 | 10.1038/s41467-025-56909-4 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Health-related quality of life predictors for patients with stroke: A prospective longitudinal study of matched pairs of patients with stroke and family caregivers | BackgroundPatients with stroke require long-term rehabilitation for functional recovery and daily activities. The health-related quality of life (HRQOL) of patients with stroke may deteriorate because of family caregivers' nonpreparedness and increased role burden.Aim(s)To investigate how caregivers' preparedness and sense of competence predict the HRQOL of patients with stroke.DesignA prospective longitudinal study.MethodsThe study population comprised patients with stroke who were hospitalized for rehabilitation and their family caregivers. A total of 158 patient-family caregiver dyads were recruited from June to September 2021. Data were collected at the initiation of rehabilitation therapy and upon discharge. Information about the characteristics of the family caregivers and patients with stroke and about the former's preparedness and sense of competence were collected at baseline. Furthermore, the HRQOL of patients with stroke was measured at baseline and upon discharge to evaluate the change.ResultsThis study of matched pairs of patients and family caregivers demonstrated that the latter's caregiving preparedness and sense of competence predicted positive changes in patients' HRQOL. Family caregivers who were satisfied with their care recipients (patients) and had better recognition of the consequences of care involvement better predicted changes in patients' HRQOL.ConclusionThe findings of this study indicate the importance of family caregivers' caregiving preparedness and sense of competence in predicting changes in patients' HRQOL.Implications for Patient CareClinically, the findings of this study highlight the importance of assessing and supporting family caregivers in developing a strong caregiving preparedness and sense of competence and in understanding the implications of their role as caregivers as it may help improve patients' HRQOL. The integration of interventions that enhance caregiver satisfaction and awareness into clinical practice may result in a more comprehensive and effective patient care.What is Already Known about this Topic? Previous studies have demonstrated that the health-related quality of life (HRQOL) of patients with stroke is influenced by sociodemographic factors, such as sex, age, marital status, pain, cognitive ability and activities of daily living. A substantial association was observed between caregivers' preparedness and the HRQOL of patients with stroke. However, few studies have examined the association between caregivers' sense of competence and the HRQOL of patients with stroke.Implications for Practice The present study indicated that clinical nursing activity must include assessment and intervention of family caregivers to improve the HRQOL of patients with stroke. The family caregivers of patients with stroke hospitalized in the post-stroke period may experience a sense of sacrifice and limitation in their personal lives. Clinical nursing practice should assess family caregivers' caregiving preparedness and sense of competence to improve the HRQOL of patients with stroke.Reporting Method This study adhered to the relevant EQUATOR guidelines and named the reporting method. | Seok, Yeaji; Lee, Myung Kyung | Kyungpook Natl Univ, Coll Nursing, Daegu, South Korea; Res Inst Nursing Sci, Coll Nursing, 680 Gukchabosangro, Daegu 41944, South Korea | 59067019100; 40661513200 | mlee@knu.ac.kr; | JOURNAL OF CLINICAL NURSING | J CLIN NURS | 0962-1067 | 1365-2702 | 34 | 4 | SCIE;SSCI | NURSING | 2024 | 3.5 | 7.0 | 0 | 2025-05-07 | 2 | 2 | caregivers; preparedness; quality of life; role burden; stroke | INFORMAL CAREGIVERS; BURDEN; PREPAREDNESS; INTERVENTION; DETERMINANTS; DISABILITY; SURVIVORS; DEMENTIA; IMPACT; SPOUSE | caregivers; preparedness; quality of life; role burden; stroke | Adult; Aged; Caregivers; Female; Humans; Longitudinal Studies; Male; Middle Aged; Prospective Studies; Quality of Life; Stroke; Stroke Rehabilitation; Surveys and Questionnaires; adult; aged; caregiver; cerebrovascular accident; female; human; longitudinal study; male; middle aged; prospective study; psychology; quality of life; questionnaire; stroke rehabilitation | English | 2025 | 2025-04 | 10.1111/jocn.17173 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy | The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy. | Jung, Sang-Hyuk; Kim, Haemin; Jung, Young Mi; Shivakumar, Manu; Xiao, Brenda; Kim, Jaeyoung; Jang, Beomjin; Yun, Jae-Seung; Won, Hong-Hee; Park, Chan-Wook; Park, Joong Shin; Jun, Jong Kwan; Kim, Dokyoon; Lee, Seung Mi | Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA; Seoul Natl Univ, Coll Med, Dept Obstet & Gynecol, Seoul, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Obstet & Gynecol, Coll Med, Seongnam, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Samsung Adv Inst Hlth Sci & Technol SAIHST, Seoul, South Korea; Catholic Univ Korea, St Vincents Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Univ Penn, Inst Biomed Informat, Philadelphia, PA 19104 USA; Seoul Natl Univ Hosp, Dept Obstet & Gynecol, Seoul, South Korea; Seoul Natl Univ Hosp, Innovat Med Technol Res Inst, Seoul, South Korea; Seoul Natl Univ, Med Big Data Res Ctr, Med Res Ctr, Seoul, South Korea; Seoul Natl Univ, Inst Reprod Med & Populat, Med Res Ctr, Seoul, South Korea | Won, Hong-Hee/D-2672-2011; Jun, Jong/D-5776-2012 | 57221354711; 57222634904; 57204270409; 57194288372; 57222610399; 57865544400; 59564900200; 55295353700; 34573851600; 34873163400; 57853769200; 59528147300; 55759503300; 58890556000 | dokyoon.kim@pennmedicine.upenn.edu; lbsm@snu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 1 | 0 | METABOLIC SYNDROME; PREECLAMPSIA; DISEASE; MANAGEMENT; MORBIDITY; MORTALITY | Adult; Atherosclerosis; Cardiovascular Diseases; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Healthy Lifestyle; Humans; Hypertension, Pregnancy-Induced; Metabolic Syndrome; Pregnancy; Risk Factors; acetylsalicylic acid; antihypertensive agent; creatinine; glucose; high density lipoprotein cholesterol; hypocholesterolemic agent; low density lipoprotein cholesterol; triacylglycerol; age structure; cardiovascular disease; health risk; hypertension; lifestyle; pregnancy; risk factor; womens health; adult; Article; cardiovascular risk; case control study; controlled study; coronary atherosclerosis; elevated blood pressure; estimated glomerular filtration rate; female; genetic predisposition; genetic risk; genome-wide association study; healthy lifestyle; human; lifestyle; major clinical study; maternal hypertension; metabolic syndrome X; observational study; atherosclerosis; cardiovascular disease; epidemiology; genetics; genome-wide association study; maternal hypertension; metabolic syndrome X; pregnancy; prevention and control; risk factor | English | 2025 | 2025-02-08 | 10.1038/s41467-025-56107-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | HSD17B4 deficiency causes dysregulation of primary cilia and is alleviated by acetyl-CoA | Primary cilia are dynamic sensory organelles orchestrating key signaling pathways, and disruption of primary ciliogenesis is implicated in a spectrum of genetic disorders. The peroxisomal bifunctional enzyme HSD17B4 is pivotal for peroxisomal beta-oxidation and acetyl-CoA synthesis, and its deficiency profoundly impairs peroxisomal metabolism. While patients with HSD17B4 deficiency exhibit ciliopathy-like symptoms due to dysfunctional primary cilia, the molecular connection between HSD17B4 and ciliopathy remains poorly understood. Here, we demonstrate that HSD17B4 deficiency impairs primary ciliogenesis and alters cilia-mediated signaling, suggesting a potential link between peroxisomal metabolism and ciliary function. Notably, elevation of acetyl-CoA rescues ciliary defects via HDAC6-mediated ciliogenesis in HSD17B4-deficient cells. Strikingly, acetate administration restores motor function, enhances primary cilia formation, and preserves the Purkinje layer in Hsd17B4-knockout mice. These findings provide insights into the functional link between HSD17B4 and primary cilia, highlighting acetyl-CoA as a potential therapeutic target for HSD17B4 deficiency and ciliopathy. | Bae, Ji-Eun; Jang, Soyoung; Kim, Joon Bum; Park, Na Yeon; Jo, Doo Sin; Hyung, Hyejin; Kim, Pansoo; Kim, Min-Seon; Ryu, Hong-Yeoul; Lee, Hyun-Shik; Lee, Dong-Seok; Baes, Myriam; Ryoo, Zae Young; Cho, Dong-Hyung | Kyungpook Natl Univ, Organelle Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 KNU Creat Biores Grp 4, Daegu, South Korea; Orgasis Corp, Suwon, Gyeonggi Do, South Korea; Asan Med Ctr, Div Endocrinol & Metab, Seoul, South Korea; Kyungpook Natl Univ, KNU Inst Basic Sci, KNU G LAMP Project Grp, Daegu, South Korea; Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Lab Cell Metab, Leuven, Belgium | RYOO, ZAEYOUNG/AAQ-1573-2020 | 57190605352; 57139360300; 57190611030; 57190609826; 56335489800; 57247294000; 59548676400; 36066824400; 55889917800; 59858434400; 57210068061; 7006799854; 16937104900; 35093684400 | jaewoong64@knu.ac.kr; dhcho@knu.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | 0 | PEROXISOMAL BETA-OXIDATION; BIFUNCTIONAL PROTEIN-DEFICIENCY; MULTIFUNCTIONAL PROTEIN-2; IDENTIFICATION; METABOLISM; DISORDERS; INSIGHTS; DEFECTS; ATAXIA; HDAC6 | Acetates; Acetyl Coenzyme A; Animals; Cilia; Ciliopathies; Histone Deacetylase 6; Humans; Male; Mice; Mice, Knockout; Peroxisomal Multifunctional Protein-2; Peroxisomes; Signal Transduction; acetic acid; acetyl coenzyme A; histone deacetylase 6; peroxisomal bifunctional enzyme; acetic acid; acetyl coenzyme A; histone deacetylase 6; HSD17B4 protein, human; peroxisomal multifunctional protein 2; acetate; cell organelle; ciliate; elevation; enzyme; enzyme activity; metabolism; protein; rodent; aged; animal cell; animal experiment; animal model; animal tissue; Article; cell organelle; ciliary motility; ciliopathy; controlled study; D bifunctional protein deficiency; fatty acid oxidation; female; gene loss; gene mutation; human; human cell; male; metabolism; motor performance; mouse; nonhuman; peroxisome; primary cilium; Purkinje cell; signal transduction; animal; cilium; genetics; knockout mouse; pathology | English | 2025 | 2025-03-18 | 10.1038/s41467-025-57793-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Microbial metabolites control self-renewal and precancerous progression of human cervical stem cells | Cervical cancer is the fourth most common female cancer, with the uterine ectocervix being the most commonly affected site. However, cervical stem cells, their differentiation, and their regulation remain poorly understood. Here, we report the isolation of a population enriched for human cervical stem cells and their regulatory mechanisms. Using single-cell RNA sequencing, we characterize the cellular heterogeneity of the human ectocervix and identify cluster-specific cell surface markers. By establishing normal and precancerous cervical organoids and an intralingual transplantation system, we show that ITGB4 and CD24 enable enrichment of human and murine ectocervical stem cells. We discover that Lactobacilli-derived lactic acid regulates cervical stem cells' self-renewal and early tumorigenesis through the PI3K-AKT pathway and YAP1. Finally, we show that D-lactic acid suppresses growth of normal and precancerous organoids, while L-lactic acid does not. Our findings reveal roles of human cervical stem cells and microbial metabolites in cervical health and diseases. | Myeong, Jihyeon; Lee, Minho; Lee, Bawool; Kim, Joon Hyung; Nam, Yeji; Choi, Yeseul; Kim, Jeongmin; Jeon, Se Young; Shim, Haewon; Jung, Da-Ryung; Shin, Youngjin; Jeong, Minsoo; Oh, Byungmoo; Jung, Jaehun; Kim, Christine S.; Han, Hyung Soo; Shin, Jae-Ho; Lee, Yoon Hee; Park, Nora Jee-Young; Chong, Gun Oh; Jeong, Youngtae | DGIST, Dept New Biol, Daegu, South Korea; Dongguk Univ, Dept Life Sci, Ilsan, Gyeonggi Do, South Korea; DGIST, New Biol Res Ctr, Daegu, South Korea; DGIST, Sch Undergraduate Studies, Daegu, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, Grad Program, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Four Program BK21, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Clin Omics Inst, Daegu, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Obstet & Gynecol, Daegu, South Korea; Kyungpook Natl Univ, Dept Pathol, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu, South Korea | Lee, Minho/ABG-5008-2020 | 57883423300; 57193161257; 59682177700; 59180650800; 59682432900; 57226123444; 57203325094; 57216296837; 59681926000; 57221116102; 58527414900; 57292954900; 57113032800; 58176711000; 57209806970; 7401969388; 57224125922; 37088851700; 57226185359; 23099068000; 56151139100 | gochong@knu.ac.kr; jyt@dgist.ac.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | 0 | HUMAN-PAPILLOMAVIRUS; CANCER; IDENTIFICATION; YAP; DIFFERENTIATION; GENERATION; CARCINOMA; PATHWAY | Animals; CD24 Antigen; Cell Self Renewal; Cervix Uteri; Disease Progression; Female; Humans; Lactic Acid; Lactobacillus; Mice; Neoplastic Stem Cells; Organoids; Phosphatidylinositol 3-Kinases; Precancerous Conditions; Single-Cell Analysis; Stem Cells; Uterine Cervical Neoplasms; YAP-Signaling Proteins; cell surface marker; hematoxylin; lactic acid; CD24 antigen; lactic acid; phosphatidylinositol 3 kinase; YAP signaling protein; YAP1 protein, human; growth response; human activity; metabolite; microbial activity; public health; RNA; adult; animal experiment; Article; carcinogenesis; cell differentiation; controlled study; ectocervix; female; flow cytometry; human; human cell; human tissue; immunohistochemistry; Lactobacillus; metabolite; metabolomics; mouse; neoplastic cell transformation; nonhuman; organoid; RNA isolation; RNA sequencing; single cell RNA seq; stem cell self-renewal; uterine cervix cancer; whole exome sequencing; animal; cancer stem cell; cell self-renewal; cytology; disease exacerbation; genetics; metabolism; microbiology; organoid; pathology; precancer; single cell analysis; stem cell; uterine cervix; uterine cervix tumor | English | 2025 | 2025-03-08 | 10.1038/s41467-025-57323-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Precisely metal doped nanographenes via a carbaporphyrin approach | Nanographenes, finite models of graphene sheets, are endowed with intriguing optical, electronic, and spintronic features. So-called heteroatom-doping, where one or more carbon is replaced by non-carbon light atoms has been proved effective in tuning the properties of nanographenes. Here we extend the concept of heteroatom nanographene doping to include metal centers. The method employed involves the use of a dipyrromethene fragment as an auxiliary ligand that is directly linked to the bay area of the model nanographene hexa-peri-hexabenzocoronene (HBC) to give a dipyrromethene-fused nanographene-type hybrid ligand (HBCP). HBCP has a corrole-like trianionic core that is capable of coordinating group 11 metal cations, including trivalent Cu, Ag and Au. These cations are introduced into the cavity with atomic precision to give metal complexes (HBCP-M; M = Cu, Ag, Au). The electronic structure and photophysical properties of HBCP and its metal complexes are investigated by steady-state and fs-transient spectroscopies, as well as DFT calculations. The ligand and metal complexes are also characterized via single crystal X-ray diffraction analyses. This work paves the way towards the precise metal doping of nanographenes within the carbon network, as opposed to the synthetic appendage of an independent chelating group, such as a fused tetrapyrrolic moiety. | He, Haodan; Lee, Jiyeon; Zong, Zhaohui; Liu, Ningchao; Noh, Yoona; Lynch, Vincent M.; Oh, Juwon; Kim, Jiwon; Sessler, Jonathan L.; Ke, Xian-Sheng | Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China; Yonsei Univ, Coll Comp, Sch Integrated Technol, Incheon 21983, South Korea; Soonchunhyang Univ, Dept Chem, Asan 31538, South Korea; Univ Texas Austin, Dept Chem, Austin, TX 78712 USA; Yonsei Univ, Underwood Int Coll, Grad Sch,Integrated Sci & Engn Div, Dept Integrat Biotechnol, Incheon 21983, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | ; Ke, Xian-Sheng/A-4608-2019; Sessler, Jonathan/AAY-7091-2021 | 58085044400; 57210790315; 58796067900; 57219413384; 59111963600; 7103251827; 55812113000; 57612765700; 7102304338; 55522916400 | juwoh933@sch.ac.kr; jiwon.kim@yonsei.ac.kr; sessler@cm.utexas.edu; kexiansheng@bnu.edu.cn; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 2.94 | 2025-05-07 | 4 | 4 | HEXA-PERI-HEXABENZOCORONENE; N-CONFUSED PORPHYRIN; GOLD(III) HEXAPHYRINS; COMPLEX; AROMATICITY; PD(II); LIGAND; AGENT | carbaporphyrin; copper; gold; graphene; metal; metal complex; metal ion; nanographene; porphyrin; silver; unclassified drug; carbon; cation; graphene; chelating agent; electronic equipment; ligand; metal; X-ray diffraction; Article; calculation; chemical procedures; complex formation; density functional theory; heteroatom doping; model; proton nuclear magnetic resonance; pump probe spectroscopy; room temperature; steady state; synthesis; transient absorption spectroscopy; X ray diffraction; article; chelation; controlled study; drug analysis | English | 2025 | 2025-02-11 | 10.1038/s41467-025-56828-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Predicting orthognathic surgery results as postoperative lateral cephalograms using graph neural networks and diffusion models | Orthognathic surgery, or corrective jaw surgery, is performed to correct severe dentofacial deformities and is increasingly sought for cosmetic purposes. Accurate prediction of surgical outcomes is essential for selecting the optimal treatment plan and ensuring patient satisfaction. Here, we present GPOSC-Net, a generative prediction model for orthognathic surgery that synthesizes post-operative lateral cephalograms from pre-operative data. GPOSC-Net consists of two key components: a landmark prediction model that estimates post-surgical cephalometric changes and a latent diffusion model that generates realistic synthesizes post-operative lateral cephalograms images based on predicted landmarks and segmented profile lines. We validated our model using diverse patient datasets, a visual Turing test, and a simulation study. Our results demonstrate that GPOSC-Net can accurately predict cephalometric landmark positions and generate high-fidelity synthesized post-operative lateral cephalogram images, providing a valuable tool for surgical planning. By enhancing predictive accuracy and visualization, our model has the potential to improve clinical decision-making and patient communication. | Kim, In-Hwan; Jeong, Jiheon; Kim, Jun-Sik; Lim, Jisup; Cho, Jin-Hyoung; Hong, Mihee; Kang, Kyung-Hwa; Kim, Minji; Kim, Su-Jung; Kim, Yoon-Ji; Sung, Sang-Jin; Kim, Young Ho; Lim, Sung-Hoon; Baek, Seung-Hak; Park, Jae-Woo; Kim, Namkug | Univ Ulsan, Asan Med Inst Convergence Sci & Technol, Asan Med Ctr, Dept Biomed Engn,Coll Med, Seoul, South Korea; SK Telecom, Seoul 04539, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Convergence Med, Seoul, South Korea; Chonnam Natl Univ, Sch Dent, Dept Orthodont, Gwangju, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Orthodont, Daegu, South Korea; Wonkwang Univ, Sch Dent, Dept Orthodont, Iksan, South Korea; Ewha Womans Univ, Coll Med, Dept Orthodont, Seoul, South Korea; Kyung Hee Univ, Sch Dent, Dept Orthodont, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Orthodont, Seoul, South Korea; Ajou Univ, Sch Med, Inst Oral Hlth Sci, Dept Orthodont, Suwon, Gyeonggi Do, South Korea; Chosun Univ, Coll Dent, Dept Orthodont, Gwangju, South Korea; Seoul Natl Univ, Dent Res Inst, Sch Dent, Dept Orthodont, Seoul, South Korea | Sung, Sang Jin/KBQ-4217-2024; Baek, Seung-Hak/NOE-8444-2025 | 57222816092; 57843623300; 57837493800; 59641217300; 15764519700; 57190379016; 35285868600; 57201330607; 58105080900; 57221435554; 7202731963; 57207443980; 36793499100; 35090967400; 57206939484; 16550058300 | jeuspark@gmail.com; namkugkim@gmail.com; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 0 | 0 | BEAM COMPUTED-TOMOGRAPHY; SOFT-TISSUE PREDICTION; ACCURACY | Anatomic Landmarks; Cephalometry; Female; Humans; Male; Neural Networks, Computer; Orthognathic Surgery; Orthognathic Surgical Procedures; Postoperative Period; Treatment Outcome; artificial neural network; data set; decision making; disease treatment; health risk; risk assessment; simulation; visualization; Article; clinical decision making; digital twin; graph neural network; orthognathic surgery; predictive model; anatomical landmark; artificial neural network; cephalometry; female; human; male; postoperative period; procedures; treatment outcome | English | 2025 | 2025-03-16 | 10.1038/s41467-025-57669-x | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice | Pain and itch are aversive sensations with distinct qualities, processed in overlapping pathways and brain regions, including the anterior cingulate cortex (ACC), which is critical for their affective dimensions. However, the cellular mechanisms underlying their processing in the ACC remain unclear. Here, we identify modality-specific neuronal populations in layer II/III of the ACC in mice involved in pain and itch processing. Using a synapse labeling tool, we show that pain- and itch-related neurons selectively receive synaptic inputs from mediodorsal thalamic neurons activated by pain and itch stimuli, respectively. Chemogenetic inhibition of these neurons reduced pruriception or nociception without affecting the opposite modality. Conversely, activation of these neurons did not enhance stimulus-specific responses but commonly increased freezing-like behavior. These findings reveal that the processing of itch and pain information in the ACC involves activity-dependent and modality-specific neuronal populations, and that pain and itch are processed by functionally distinct ACC neuronal subsets. | Ko, Hyoung-Gon; Jung, Hyunsu; Han, Seunghyo; Choi, Dong Il; Lee, Chiwoo; Choi, Ja Eun; Oh, Jihae; Kwak, Chuljung; Han, Dae Hee; Kim, Jun-Nyeong; Ye, Sanghyun; Lee, Jiah; Lee, Jaehyun; Lee, Kyungmin; Lee, Jae-Hyung; Zhuo, Min; Kaang, Bong-Kiun | Kyungpook Natl Univ, Brain Sci & Engn Inst, Sch Dent, Dept Anat & Neurobiol, 2177 Dalgubeol Daero, Daegu, South Korea; Kyung Hee Univ, Coll Dent, Dept Oral Anat & Dev Biol, Seoul, South Korea; Inst Basic Sci IBS, Ctr Cognit & Social, Daejeon 34126, South Korea; Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, 1 Gwanangno, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Lab Behav Neural Circuitry & Physiol,Dept Anat, 680 Gukchaebosang Ro, Daegu, South Korea; Kyung Hee Univ, Coll Dent, Dept Oral Microbiol, 26 Kyungheedae Ro, Seoul, South Korea; Univ Toronto, Fac Med, Dept Physiol, 1 Kings Coll Circle, Toronto, ON, Canada; Qingdao Int Academician Pk, Int Inst Brain Res, Qingdao, Peoples R China | Lee, Jae-Hyung/AAI-9813-2020; Ko, Hyoung-Gon/KQU-8680-2024; Choi, Ja Eun/HTR-6298-2023 | 14522654800; 57222349738; 58751707300; 57201740255; 57209978753; 57194772568; 57199948390; 26435938700; 57203166129; 58790999200; 58956903100; 57226124566; 57203144612; 59812978300; 55690041500; 7006167256; 7003889686 | hgko@khu.ac.kr; kaang@ibs.re.kr; | NATURE COMMUNICATIONS | NAT COMMUN | 2041-1723 | 16 | 1 | SCIE | MULTIDISCIPLINARY SCIENCES | 2024 | 15.7 | 7.0 | 0 | 2025-05-07 | 1 | 1 | PREFRONTAL CORTEX; MEMORY; COMPETITION; MECHANISMS; ALLOCATION; TURNOVER; CIRCUITS; CHANNELS | Animals; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurons; Nociception; Pain; Pruritus; Synapses; brain; cell; cell component; inhibition; rodent; animal cell; animal experiment; animal model; animal tissue; anterior cingulate; Article; brain region; chemogenetics; comparative study; controlled study; freezing; interneuron; mouse; nerve cell; nociception; nonhuman; pain; pruritus; synapse; thalamus; animal; C57BL mouse; cingulate gyrus; male; pathophysiology; physiology; transgenic mouse | English | 2025 | 2025-03-04 | 10.1038/s41467-025-57041-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | AST-001 versus placebo for social communication in children with autism spectrum disorder: A randomized clinical trial | Aim: This study examined the efficacy of AST-001 for the core symptoms of autism spectrum disorder (ASD) in children. Methods: This phase 2 clinical trial consisted of a 12-week placebo-controlled main study, a 12-week extension, and a 12-week follow-up in children aged 2 to 11 years with ASD. The participants were randomized in a 1:1:1 ratio to a high-dose, low-dose, or placebo-to-high-dose control group during the main study. The placebo-to-high-dose control group received placebo during the main study and high-dose AST-001 during the extension. The a priori primary outcome was the mean change in the Adaptive Behavior Composite (ABC) score of the Korean Vineland Adaptive Behavior Scales II (K-VABS-II) from baseline to week 12. Results: Among 151 enrolled participants, 144 completed the main study, 140 completed the extension, and 135 completed the follow-up. The mean K-VABS-II ABC score at the 12th week compared with baseline was significantly increased in the high-dose group (P = 0.042) compared with the placebo-to-high-dose control group. The mean CGI-S scores were significantly decreased at the 12th week in the high-dose (P = 0.046) and low-dose (P = 0.017) groups compared with the placebo-to-high-dose control group. During the extension, the K-VABS-II ABC and CGI-S scores of the placebo-to-high-dose control group changed rapidly after administration of high-dose AST-001 and caught up with those of the high-dose group at the 24th week. AST-001 was well tolerated with no safety concern. The most common adverse drug reaction was diarrhea. Conclusions: Our results provide preliminary evidence for the efficacy of AST-001 for the core symptoms of ASD. | Kim, Hyo-Won; Kim, Ji-Hoon; Chung, Un Sun; Kim, Johanna Inhyang; Shim, Se-hoon; Park, Tae Won; Lee, Moon-Soo; Hwang, Jun-Won; Park, Eun-Jin; Hwang, Su-Kyeong; Joung, Yoo-Sook | Univ Ulsan, Coll Med, Asan Med Ctr, Dept Psychiat, Seoul, South Korea; Pusan Natl Univ Hosp, Dept Psychiat, Pusan, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu 700422, South Korea; Hanyang Univ Med Ctr, Dept Psychiat, Seoul, South Korea; Soon Chun Hyang Univ, Cheonan Hosp, Dept Pathol, Div Gastroenterol, Cheonan 330721, Choongnam, South Korea; Jeonbuk Natl Univ, Coll Med, Dept Psychiat, Jeonju, South Korea; Korea Univ, Korea Univ Guro Hosp, Coll Med, Dept Psychiat, Seoul 152703, South Korea; Korea Univ, Dept Life Sci, Seoul, South Korea; Kangwon Natl Univ, Sch Med, Dept Psychiat, Chunchon, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Psychiat, Goyang, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Psychiat, Seoul, South Korea | KIM, Hyeon-Joong/C-4448-2011; Lee, Moon-Soo/B-1203-2016; Kim, Hyo-Won/M-9932-2019 | 13402798900; 57233285600; 24477437300; 56177337000; 14008659900; 55716995000; 25932192700; 8606982500; 58304774100; 37761570400; 14012278200 | yschoung@skku.edu; | PSYCHIATRY AND CLINICAL NEUROSCIENCES | PSYCHIAT CLIN NEUROS | 1323-1316 | 1440-1819 | 79 | 1 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES;PSYCHIATRY | 2024 | 6.2 | 7.1 | 10.81 | 2025-05-07 | 4 | 4 | autism; children; clinical trial; social communication | L-SERINE; YOUNG-CHILDREN; BEHAVIOR; INDIVIDUALS; ADOLESCENTS; PLASTICITY | autism; children; clinical trial; social communication | Autism Spectrum Disorder; Child; Child, Preschool; Double-Blind Method; Female; Humans; Male; Outcome Assessment, Health Care; ast 001; central nervous system agents; placebo; unclassified drug; Adaptive Behavior Composite score; Article; autism; child; comparative study; constipation; controlled study; coronavirus disease 2019; coughing; decreased appetite; diarrhea; drug efficacy; drug megadose; drug safety; drug tolerance; female; fever; follow up; human; interpersonal communication; Korean Vineland Adaptive Behavior Scales II; low drug dose; major clinical study; male; phase 2 clinical trial; randomized controlled trial; rhinopharyngitis; scoring system; social interaction; treatment duration; vomiting; autism; clinical trial; double blind procedure; drug therapy; outcome assessment; preschool child | English | 2025 | 2025-01 | 10.1111/pcn.13757 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Bifunctionally Hydrophobic MOF-Supported Platinum Catalyst for the Removal of Ultralow Concentration Hydrogen Isotope | Water often presents significant challenges in catalysts by deactivating active sites, poisoning the reaction, and even degrading composite structure. These challenges are amplified when the water participates as a reactant and is fed as a liquid phase, such as trickle bed-type reactors in a hydrogen-water isotope exchange (HIE) reaction. The key balance in such multiphase reactions is the precise control of catalyst design to repel bulk liquid water while diffusing water vapor. Herein, a platinum-incorporated metal-organic framework (MIL-101) based bifunctional hydrophobic catalyst functionalized with long alkyl chains (C-12, dodecylamine) and further manufactured with poly(vinylidene fluoride), Pt@MIL-101-12/PVDF, has been developed which can show dramatically improved catalytic activity under multi-phase reactions involving hydrogen gas and liquid water. Pt@MIL-101-12/PVDF demonstrates enhanced macroscopic water-blocking properties, with a notable reduction of over 65% in water adsorption capacity and newly introduced liquid water repellency, while exhibiting a negligible increase in mass transfer resistance, i.e., bifunctional hydrophobicity. Excellent catalytic activity, evaluated via HIE reaction, and its durability underscore the impact of bifunctional hydrophobicity. In situ DRIFTS analysis elucidates water adsorption/desorption dynamics within the catalyst composite, highlighting reinforced water diffusion at the microscopic level, affirming the catalyst's bifunctionality in different length scales. With demonstrated radiation resistance, Pt@MIL-101-12/PVDF emerges as a promising candidate for isotope exchange reactions. | Heo, Huiryung; Jang, Jeong-un; Jeong, Euna; Kim, Hyung-Ju; Kim, Young Jin; Park, Chan Woo; So, Jungseob; Koh, Dong-Yeun | Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, 291 Daehak ro, Daejeon 34141, South Korea; Korea Atom Energy Res Inst, Decommissioning Technol Div, 111,Daedeok daero 989beon gil, Daejeon 34057, South Korea; Chungnam Natl Univ, Dept Chem Engn & Appl Chem, 99 Daehak ro, Daejeon 34134, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, CO2 & Energy Res Ctr, Daejeon 34114, South Korea; Saudi Aramco KAIST CO2 Management Ctr, 291 Daehak Ro, Daejeon 34141, South Korea | So, Jungseob/LRT-7397-2024; Koh, Dong-Yeun/N-7408-2017; Park, Chan Woo/KSL-6049-2024 | 59242238000; 59241425200; 58687125100; 57074136400; 59054565400; 57191821580; 57192270014; 24474680800 | chanwoo@kaeri.re.kr; jsso@krict.re.kr; dongyeunkoh@kaist.ac.kr; | ENERGY & ENVIRONMENTAL MATERIALS | ENERGY ENVIRON MATER | 2575-0356 | 8 | 2 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY | 2024 | 14.1 | 7.1 | 0 | 2025-05-07 | 0 | 0 | bifunctional hydrophobic catalyst; hydrogen-water isotope exchange; hydrophobic modification; metal-organic framework; tritium removal | PT/SDBC CATALYST; TRITIUM; SEPARATION | bifunctional hydrophobic catalyst; hydrogen-water isotope exchange; hydrophobic modification; metal–organic framework; tritium removal | Catalyst activity; Catalyst poisoning; Catalyst supports; Fluorine compounds; Hydrophobicity; Isotopes; Mass transfer; Organometallics; Platinum; Bi-functional; Bifunctional hydrophobic catalyst; Hydrogen-water isotope exchange; Hydrophobic catalysts; Hydrophobic modification; Isotope exchange; Isotope exchange reactions; Metalorganic frameworks (MOFs); Tritium removal; Water isotope; Hydrogen | English | 2025 | 2025-03 | 10.1002/eem2.12815 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | C1,α regularity for degenerate fully nonlinear elliptic equations with oblique boundary conditions on C1 domains | We provide a sharp C1,alpha estimate up to the boundary for a viscosity solution of a degenerate fully nonlinear elliptic equation with the oblique boundary condition on a C1 domain. To this end, we first obtain a uniform boundary H & ouml;lder estimate with the oblique boundary condition in an "almost C1-flat" domain for the equations which is uniformly elliptic only where the gradient is far from some point, and then we establish a desired C1,alpha regularity based on perturbation and compactness arguments. | Byun, Sun-Sig; Kim, Hongsoo; Oh, Jehan | Seoul Natl Univ, Dept Math Sci, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Math, Seoul 08826, South Korea; Seoul Natl Univ, Dept Math Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea | 8350569400; 59452159300; 56673305300 | byun@snu.ac.kr; rlaghdtn98@snu.ac.kr; jehan.oh@knu.ac.kr; | CALCULUS OF VARIATIONS AND PARTIAL DIFFERENTIAL EQUATIONS | CALC VAR PARTIAL DIF | 0944-2669 | 1432-0835 | 64 | 5 | SCIE | MATHEMATICS, APPLIED;MATHEMATICS | 2024 | 2 | 7.1 | 0 | 2025-06-11 | 0 | 0 | English | 2025 | 2025-06 | 10.1007/s00526-025-03042-1 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Development and applications of the real-time polymerase chain reaction method for rapid quantitative detection of the newly emerged novel genotype of Decapod hepandensovirus 1 in Penaeus vannamei | Decapod hepandensovirus 1 (decapod hepanhamaparvovirus [DHPV]) is a member of the family Parvoviridae. The natural host of DHPV includes various captured or cultured penaeid shrimp species. The virus infects the host's hepatopancreas, leading to disturbance in digestion and reduced shrimp yields, causing substantial economic losses. Recently, the emergence of a new DHPV genotype (nDHPV) in Penaeus vannamei has been reported, and considering that the shrimp is one of the most extensively cultivated species in the global aquaculture industry, the development of diagnostic methods for the virus is urgent. To address the need for accurate detection and diagnosis of nDHPV, this study presents a diagnostic quantitative polymerase chain reaction method designed to detect the virus currently prevalent in P. vannamei. The assay was applied to various nDHPV-positive samples to confirm its practical utility and quantify the prevalence of nDHPV. Moreover, the analytical specificity of this assay to other several shrimp pathogens was also addressed. To the best of our knowledge, this study represents the first report of a quantitative method based on nDHPV identified from P. vannamei. The findings provide valuable insights into the pathogenesis and epidemiology of nDHPV in this economically significant species. | Kim, Bumkeun; Lee, Chorong; Jeon, Hye Jin; Piamsomboon, Patharapol; Kim, Ji Hyung; Han, Jee Eun | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Chulalongkorn Univ, Fac Vet Sci, Dept Vet Med, Bangkok, Thailand; Chulalongkorn Univ, Vet Med Aquat Anim Res Ctr Excellence, Bangkok, Thailand; Gachon Univ, Dept Food Sci & Biotechnol, Seongnam 13120, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci IALS, Jinju 52828, South Korea | Kim, Ji Hyung/B-7321-2011 | 57225056167; 56707749200; 57212193058; 56106906400; 57225000204; 57214671240 | kzh81@gachon.ac.kr; jehan@knu.ac.kr; | AQUACULTURE | AQUACULTURE | 0044-8486 | 1873-5622 | 595 | SCIE | FISHERIES;MARINE & FRESHWATER BIOLOGY | 2024 | 3.9 | 7.1 | 0 | 2025-05-07 | 0 | 0 | Decapod hepandensovirus 1; Hepatopancreatic parvovirus; Penaeus vannamei; Quantitative PCR; Diagnosis | HEPATOPANCREATIC PARVOVIRUS HPV; SPOT SYNDROME VIRUS; NECROSIS DISEASE; CAUSATIVE AGENT; PCR; DNA | Decapod hepandensovirus 1; Diagnosis; Hepatopancreatic parvovirus; Penaeus vannamei; Quantitative PCR | aquaculture industry; epidemiology; genotype; pathogen; polymerase chain reaction; prawn culture | English | 2025 | 2025-01-30 | 10.1016/j.aquaculture.2024.741568 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Dual-Modal Sensing Skin Adaptive to Daylight, Darkness, and Ultraviolet Light for Simultaneous Full-Field Deformation Measurement and Mechanoluminescence Responses | Mechanoluminescence (ML) and digital image correlation (DIC) have emerged as promising optical methods to visualize and measure deformation fields. In this study, a dual-modal sensing skin, called the ML-DIC skin is introduced, that is capable of emitting ML and facilitating DIC measurements under various lighting conditions, including daylight, night or darkness, and UV irradiation. Four ML-DIC skins are fabricated with or without carbon nanotubes (CNTs) using a composite powder consisting of SrAl2O4: Eu,Dy (SAO), and acrylic resin, with CNT milling times of 48, 72, and 96 h for three of four skins, respectively. DIC measurements are performed under multiple lighting conditions for measuring photoluminescence, persistence luminescence, and reflection. Uniaxial tension tests demonstrate the superior performance of ML-DIC skins with CNTs compared with pristine SAO skins, with the skin subjected to 48 h of CNT dispersion exhibiting optimal performance. Further investigations focus on ML emission and DIC measurements near the crack-tip vicinity of static and propagating cracks as well as on surfaces above subsurface cracks. The integration of ML and DIC techniques offers a versatile approach for comprehensive deformation analysis applicable to diverse environments, with implications for materials science, engineering, and structural health monitoring. | Timilsina, Suman; Jo, Cheol Woo; Lee, Kwang Ho; Sohn, Kee-Sun; Kim, Ji Sik | Kyungpook Natl Univ, KNU Res Inst Artificial Intelligent Diag Technol M, Kyeongbuk 37224, South Korea; Kyungpook Natl Univ, Sch Adv Sci & Technol Convergence, Kyeongbuk 37224, South Korea; Kyungpook Natl Univ, Dept Automot Engn, Kyeongbuk 37224, South Korea; Sejong Univ, Nanotechnol & Adv Mat Engn, 209 Neungdong Ro, Seoul 143747, South Korea; Kyungpook Natl Univ, Sch Nano & Adv Mat Engn, Kyeongbuk 37224, South Korea | Timilisina, Suman/GLT-8029-2022 | 55844969100; 58643182700; 56348794600; 56067767800; 16444690100 | khl@knu.ac.kr; kssohn@sejong.ac.kr; jisikkim@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 12 | 2 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 14.1 | 7.1 | 3.92 | 2025-05-07 | 4 | 4 | digital image correlation; light-adaptive skin; mechanoluminescence; structural health monitoring; subsurface crack | PHOSPHOR | digital image correlation; light-adaptive skin; mechanoluminescence; structural health monitoring; subsurface crack | Laser beams; Photoluminescence; Strontium alloys; acrylic acid resin; carbon nanotube; Correlation measurement; Digital image correlations; Field deformations; Health monitoring; Light-adaptive skin; Lighting conditions; Structural health; Subsurface cracks; Ultra-violet light; Ultraviolet lights; article; controlled study; darkness; dispersion; illumination; luminescence; night; photoluminescence; powder; skin; sunlight; ultraviolet irradiation; ultraviolet radiation; Yarn | English | 2025 | 2025-01 | 10.1002/advs.202409384 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Ecofriendly Upcycling of Poly(vinyl chloride) Waste Plastics into Precious Metal Adsorbents | Global interest in the recycling of precious metals (PMs) in various industrial sectors has spurred the exploration of high-performance PM adsorbents. Unfortunately, many adsorbents exhibit unsatisfactory PM adsorption performance and require complex fabrication protocols and toxic chemicals. Hence, further development of simple, efficient, and eco-friendly adsorbents is necessary. Herein, poly(vinyl chloride) (PVC) waste plastics are simply transformed into high-performance PM adsorbents via benign solvent treatment and hydrazination. The resultant hydrazine-functionalized PVC (h-PVC) plastic can effectively recover gold, palladium, and platinum from real-world leachates owing to its combined reduction and chemisorption mechanisms. The PM-adsorbed h-PVC plastic can be regenerated, calcined into high-purity PMs, or directly employed as a catalyst, demonstrating its practical feasibility. Techno-economic and life-cycle assessments reveal that the h-PVC plastic-utilizing industrial-scale recovery of gold from electronic waste is cost-competitive and environmentally advantageous. The strategy supports environmental and sustainable technologies by enabling the sustainable maintenance of carbon and PM resources and provides an efficient and sustainable method for fabricating advanced adsorbent materials. © 2025 The Author(s). Advanced Science published by Wiley-VCH GmbH. | Shin, Seung Su; Lee, Seungho; Park, Sung-Joon; Kim, Hansoo; Choi, Juyeon; Won, Wangyun; Lee, Jung-Hyun | Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea; Department of Polymer Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea; Department of Chemical and Biological Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul, 02841, South Korea | 57215684245; 55716384900; 59873295400; 57202104236; 58112763600; 16644098000; 56011564600 | wwon@korea.ac.kr; leejhyyy@korea.ac.kr; | Advanced Science | ADV SCI | N/A | 2198-3844 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 14.1 | 7.1 | N/A | 0 | eco-friendly upcycling; hydrazine functionalization; poly(vinyl chloride); precious metal adsorbent; waste plastic upcycling | Cleaner production; Environmental management systems; Environmental regulations; Green manufacturing; Palladium; Plastics industry; Platinum; Eco-friendly; Eco-friendly upcycling; Functionalizations; Hydrazine functionalization; Metal adsorbents; Poly(vinyl chloride); Precious metal adsorbent; Waste plastic; Waste plastic upcycling; Environmental Protection Agency | English | Article in press | 2025 | 10.1002/advs.202503157 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Ferromagnetic Nickel as a Sustainable Reducing Agent for Tin-Lead Mixed Perovskite in Single-Junction and Tandem Solar Cells | Narrow-bandgap (NBG) Sn-Pb mixed perovskite solar cells (PSCs) represent a promising solution for surpassing the radiative efficiency of single-junction solar cells. The unique bandgap tunability of halide perovskites enables optimal tandem configurations of wide-bandgap (WBG) and NBG subcells. However, these devices are limited by the susceptibility of Sn2+ in the NBG bottom cell to being oxidized to Sn4+, creating detrimental Sn vacancies. Herein, a novel approach that replaces Sn particles with Ni particles is introduced as the reducing agent for Sn-Pb mixed perovskite precursor solutions. The ferromagnetic properties of Ni enable simple magnetic filtration, eliminating the filtration issues associated with Sn particles. Ni particles can be reused up to five times without significantly affecting the PSC's performance. Additionally, Ni effectively mitigates the oxidation of Sn2+ due to its low reduction potential (-0.23 V), thereby enhancing device performance. Single-junction Sn-Pb mixed PSCs prepared using Ni achieve a power-conversion efficiency (PCE) of 22.29%, retaining over 90% of their initial efficiency after 1250 h. Furthermore, Ni-based all-perovskite tandem solar cells combining 1.77 eV WBG top cells with 1.25 eV NBG bottom cells achieve a remarkable PCE of 28.13%. Thus, the proposed strategy can facilitate the commercialization of all-perovskite tandem devices. | Im, Doyun; Boonmongkolras, Passarut; Yun, Yeonghun; Yang, Sung Woong; Kim, Sunwoo; Yun, Jungchul; Gunasekaran, Rajendra Kumar; Seo, You-Hyun; Jeon, Nam Joong; Han, Gill Sang; Lee, Sangwook | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Res Inst Chem Technol KRICT, Adv Energy Mat Res Ctr, Daejeon 34114, South Korea; Helmholtz Zentrum Berlin Materialien & Energie Gmb, Dept Perovskite Tandem Solar Cells, D-12489 Berlin, Germany | Lee, Sangwook/O-9166-2015; Gunasekaran, Rajendra Kumar/ISU-5759-2023; Jeon, Nam/X-4523-2018 | 58786742800; 57194537843; 57202548363; 58055005400; 59410048500; 58066629400; 57201582809; 56473210700; 55855523800; 36463511300; 57203597324 | gshan@krict.re.kr; wook2@knu.ac.kr; | ADVANCED SCIENCE | ADV SCI | 2198-3844 | 12 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2024 | 14.1 | 7.1 | 0 | 2025-05-07 | 1 | 1 | all-perovskite tandem solar cells; recyclable reducing agents; Sn-Pb mixed perovskites; standard reduction potentials | PB; SN; EFFICIENCY; OXIDATION | all-perovskite tandem solar cells; recyclable reducing agents; Sn–Pb mixed perovskites; standard reduction potentials | Conducting polymers; Gallium compounds; Layered semiconductors; Magnetic bubbles; Magnetic filters; Microfiltration; Nickel; Perovskite; Tin alloys; erythromycin; halide; nickel; perovskite; reducing agent; tin; All-perovskite tandem solar cell; Bottom cells; Narrow bandgap; Recyclable reducing agent; Recyclables; Single junction solar cells; Sn–pb mixed perovskite; Standard reduction potentials; Tandem solar cells; Wide-band-gap; article; controlled study; filtration; human; human cell; oxidation; pharmaceutics; reduction (chemistry); solar cell; Perovskite solar cells | English | 2025 | 2025-02 | 10.1002/advs.202411403 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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