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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Meeting Abstract ⓘ Anticancer nanocage platforms for combined immunotherapy designed to harness immune checkpoints and deliver anticancer drugs. ⓘ ⓘ Kim, Soyoun; Kim, Minseong ⓘ Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ CANCER RESEARCH ⓘ CANCER RES ⓘ 0008-5472 1538-7445 81 13 SCIE ONCOLOGY ⓘ 2021 13.312 8.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-07 ⓘ 바로가기 바로가기
○ Meeting Abstract ⓘ Arsenic hexoxide has differential effects on cell proliferation and genome-wide gene expression in human primary mammary epithelial and mcf7 cells. ⓘ ⓘ Bunch, Heeyoun; Kim, Donguk; Park, Na Yeon; Jeong, Jaehyeon; Kang, Keunsoo; Calderwood, Stuart K.; Cho, Dong-Hyung; Bae, Ill Ju ⓘ Kyungpook Natl Univ, Daegu, South Korea; Dankook Univ, Cheonan, South Korea; Harvard Med Sch, Bostron, MA USA; Chemas Pharmaceut, Seoul, South Korea ⓘ Choi, Hye Rin/JDV-9065-2023; Kang, Keunsoo/AFM-7746-2022; Bunch, Heeyoun/JAX-3215-2023 ⓘ ⓘ ⓘ CANCER RESEARCH ⓘ CANCER RES ⓘ 0008-5472 1538-7445 81 13 SCIE ONCOLOGY ⓘ 2021 13.312 8.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-07 ⓘ 바로가기 바로가기
○ ○ Article ⓘ Circulating Small Extracellular Vesicles Activate TYRO3 to Drive Cancer Metastasis and Chemoresistance ⓘ Extracellular vesicles (EV) in the tumor microenvironment have emerged as crucial mediators that promote proliferation, metastasis, and chemoresistance. However, the role of circulating small EVs (csEV) in cancer progression remains poorly understood. In this study, we report that csEV facilitate cancer progression and determine its molecular mechanism. csEVs strongly promoted the migration of cancer cells via interaction with phosphatidylserine of csEVs. Among the three TAM receptors, TYRO3, AXL, and MerTK, TYRO3 mainly interacted with csEVs. csEV-mediated TYRO3 activation promoted migration and metastasis via the epithelial-mesenchymal transition and stimulation of RhoA in invasive cancer cells. Additionally, csEV-TYRO3 interaction induced YAP activation, which led to increased cell proliferation and chemoresistance. Combination treatment with gefitinib and KRCT-6j, a selective TYRO3 inhibitor, significantly reduced tumor volume in xenografts implanted with gefitinib-resistant non-small cell lung cancer cells. The results of this study show that TYRO3 activation by csEVs facilitates cancer cell migration and chemoresistance by activation of RhoA or YAP, indicating that the csEV/TYRO3 interaction may serve as a potential therapeutic target for aggressive cancers in the clinic. Significance: These findings demonstrate that circulating extracellular vesicles are a novel driver in migration and survival of aggressive cancer cells via TYRO3 activation. ⓘ Park, Miso; Kim, Ji Won; Kim, Kyu Min; Kang, Seungmin; Kim, Wankyu; Kim, Jin-Ki; Cho, Youngnam; Lee, Hyungjae; Baek, Moon Chang; Bae, Ju-Hyun; Lee, Seung Hyun; Jeong, Sung Baek; Lim, Sung Chul; Jun, Dae Won; Cho, Sung Yun; Kim, Yeonji; Choi, Yong June; Kang, Keon Wook ⓘ Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea; Univ Calif San Francisco, Div Hematol & Med Oncol, San Francisco, CA 94143 USA; Chosun Univ, Coll Pharm, Gwangju, South Korea; Chosun Univ, Coll Nat Sci, Dept Biomed Sci, Gwangju, South Korea; Ewha Womans Univ, Dept Life Sci, Div Mol & Life Sci, Seoul, South Korea; KaiPharm, Seoul, South Korea; Hanyang Univ, Coll Pharm, Ansan, Gyeonggi, South Korea; Natl Canc Ctr, Biomarker Branch, Gyeonggi, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu, South Korea; Chosun Univ, Coll Med, Dept Pathol, Gwangju, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Korea Res Inst Chem Technol, Dept Drug Discovery, Daejeon, South Korea; Sungkyunkwan Univ, Dept Chem, Suwon, South Korea ⓘ Kim, Jung Oh/JDC-5061-2023; Kim, Eun/AAS-6706-2020; Jun, Dae Won/O-4529-2017; Choi, Kyuhee/D-5885-2011; kim, kyumin/KDN-4319-2024; Choi, Yong-June/K-4505-2012 ⓘ 57209249625; 57188693753; 56441871900; 56988085900; 25627654100; 59865314800; 7404468845; 56593913100; 7006013097; 57225046295; 57225054763; 57193096463; 57217265869; 8662222500; 7404884103; 57220633076; 57225049189; 57281306300 ⓘ kwkang@snu.ac.kr; ⓘ CANCER RESEARCH ⓘ CANCER RES ⓘ 0008-5472 1538-7445 81 13 SCIE ONCOLOGY ⓘ 2021 13.312 8.0 0.96 2025-07-30 ⓘ 15 16 ⓘ RECEPTOR TYROSINE KINASES; TGF-BETA; TAM RECEPTOR; TUMOR; YAP; METHOTREXATE; PHYSIOLOGY; RESPONSES; PATHWAYS; DESIGN ⓘ ⓘ Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Extracellular Vesicles; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Receptor Protein-Tyrosine Kinases; Splenic Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; albumin; alpha tubulin; cofilin; connective tissue growth factor; eosin; erlotinib; gefitinib; glutaraldehyde; glyceraldehyde 3 phosphate dehydrogenase; hematoxylin; iodixanol; lipofectamine; liposome; nerve cell adhesion molecule; paraformaldehyde; penicillin derivative; phalloidin; phosphate buffered saline; phosphatidylserine; puromycin; streptomycin; gefitinib; protein tyrosine kinase; tumor marker; TYRO3 protein, human; animal cell; animal experiment; animal model; Article; breast cancer; cancer cell; cancer growth; cell culture; cell migration; cell proliferation; chemoluminescence; colon cancer; controlled study; CRISPR Cas system; density gradient centrifugation; epithelial mesenchymal transition; exosome; fetal bovine serum; genetic transfection; immunocytochemistry; immunoprecipitation; luciferase assay; metastasis; mouse; Mycoplasma; non small cell lung cancer; nonhuman; pathology; prostate cancer; retrovirus infection; transmission electron microscopy; tumor microenvironment; ultracentrifugation; Western blotting; xenograft; animal; apoptosis; Bagg albino mouse; drug resistance; drug screening; exosome; gene expression regulation; genetics; human; liver tumor; male; metabolism; neoplasm; nude mouse; pathology; spleen tumor; tumor cell culture ⓘ English 2021 2021-07-01 10.1158/0008-5472.can-20-3320 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ecological compensation: How much and where? ⓘ We develop a normative approach to optimal environmental compensation in a spatial framework. We determine both the location and the level of compensation that minimize the total cost of restoration while maintaining the social welfare unchanged. In our framework, the policy maker implements a No Net Loss policy that meets the No Worse-Off principle as well as a location constraint on the offset. We describe the additional ecological cost induced by the No Worse-Off principle and how the spatial distribution of individuals, the environment and land costs affect the compensation location. The location constraint is shown to give rise to a trade-off between the compensation cost and the inequality among individuals induced by the policy. ⓘ Gastineau, Pascal; Mossay, Pascal; Taugourdeau, Emmanuelle ⓘ Univ Gustave Eiffel, AME SPLOTT, IFSTTAR, Allee Ponts & Chaussees, F-44344 Bouguenais, France; Kyungpook Natl Univ, Dept Econ, Daegu, South Korea; Inst Polytech Paris, Ecole Polytech, ENSAE, CNRS,CREST, F-91128 Palaiseau, France ⓘ ⓘ 41261468400; 56418345000; 6507411382 ⓘ pascal.mossay@knu.ac.kr; ⓘ ECOLOGICAL ECONOMICS ⓘ ECOL ECON ⓘ 0921-8009 1873-6106 190 SCIE;SSCI ECOLOGY;ECONOMICS;ENVIRONMENTAL SCIENCES;ENVIRONMENTAL STUDIES ⓘ 2021 6.536 8.0 3.54 2025-07-30 ⓘ 54 59 Ecological compensation; No net loss policy; Welfare; Inequality ⓘ NO NET LOSS; BIODIVERSITY OFFSETS; WETLAND MITIGATION; IMPACTS; LAND ⓘ Ecological compensation; Inequality; No net loss policy; Welfare ⓘ compensation system; ecological economics; environmental policy; environmental restoration; policy making; spatial distribution; trade-off ⓘ English 2021 2021-12 10.1016/j.ecolecon.2021.107191 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ High-redshift Narrow-line Seyfert 1 Galaxies: A Candidate Sample ⓘ The study of narrow-line Seyfert 1 galaxies (NLS1s) is now mostly limited to low redshift (z 0.8. We studied the correlation between the properties of H beta and Mg ii lines of a large sample of SDSS DR14 quasars to find high-z NLS1 candidates. Based on the strong correlation of FWHM(Mg II) = (0.880 0.005) x FWHM(H beta) + (0.438 0.018), we present a sample of high-z NLS1 candidates having FWHM of Mg ii < 2000 km s(-1). The high-z sample contains 2684 NLS1s with redshift z = 0.8-2.5 with a median logarithmic bolometric luminosity of 46.16 0.42 erg s(-1), logarithmic black hole mass of 8.01 0.35 M, and logarithmic Eddington ratio of 0.02 0.27. The fraction of radio-detected high-z NLS1s is similar to that of the low-z NLS1s and SDSS DR14 quasars at a similar redshift range, and their radio luminosity is found to be strongly correlated with their black hole mass. ⓘ Rakshit, Suvendu; Stalin, C. S.; Kotilainen, Jari; Shin, Jaejin ⓘ Univ Turku, Finnish Ctr Astron ESO FINCA, Quantum, Vesilinnantie 5, FI-20014 Turku, Finland; Aryabhatta Res Inst Observat Sci, Manora Peak 263002, Nainital, India; Indian Inst Astrophys, Block 2, Bangalore 560034, Karnataka, India; Univ Turku, Dept Phys & Astron, Tuorla Observ, FI-20014 Turku, Finland; Kyungpook Natl Univ, Dept Astron & Atmospher Sci, Daegu 41566, South Korea ⓘ ⓘ 55572266300; 6603346246; 55924792900; 55554622900 ⓘ suvenduat@gmail.com; ⓘ ASTROPHYSICAL JOURNAL SUPPLEMENT SERIES ⓘ ASTROPHYS J SUPPL S ⓘ 0067-0049 1538-4365 253 1 SCIE ASTRONOMY & ASTROPHYSICS ⓘ 2021 9.2 8.0 0.07 2025-07-30 ⓘ 9 5 Quasars; Supermassive black holes; Spectroscopy ⓘ ⓘ Spectroscopy (1558); Supermassive black holes (1663); Unified Astronomy Thesaurus concepts: Quasars (1319) ⓘ ⓘ English 2021 2021-03 10.3847/1538-4365/abd9bb ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Real Hypersurfaces with Quadratic Killing Normal Jacobi Operator in the Real Grassmannians of Rank Two ⓘ In this paper, first we introduce a new notion of (quadratic) Killing normal Jacobi operator (or cyclic parallel normal Jacobi operator) and its geometric meaning for real hypersurfaces in the real Grassmannians of rank two Q(m)(epsilon), epsilon = +/- 1, where Q(m)(epsilon) denotes the complex quadric Q(m)(epsilon) = Q(m) = SOm+2/SOmSO2 for epsilon = 1 and Q(m)(epsilon) = Q(m)* = SOm,20/SOmSO2 for epsilon = -1, respectively. Next, we give a non-existence theorem for Hopf real hypersurfaces satisfying quadratic Killing normal Jacobi operator in the real Grassmannians of rank two Q(m)(epsilon). ⓘ Lee, Hyunjin; Suh, Young Jin ⓘ Kyungpook Natl Univ, Res Inst Real & Complex Manifolds RIRCM, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kyungpook Natl Univ, RIRCM, Daegu 41566, South Korea ⓘ ⓘ 55706812200; 7202260479 ⓘ lhjibis@hanmail.net;yjsuh@knu.ac.kr; ⓘ RESULTS IN MATHEMATICS ⓘ RESULTS MATH ⓘ 1422-6383 1420-9012 76 3 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2021 2.214 8.0 0.5 2025-07-30 ⓘ 6 3 (Quadratic) Killing normal Jacobi operator; cyclic parallel normal Jacobi operator; A-isotropic; A-principal; real hypersurfaces; real Grassmannians of rank two; complex quadric; complex hyperbolic quadric ⓘ COMPLEX PROJECTIVE-SPACE; EINSTEIN HYPERSURFACES; FORMS ⓘ (Quadratic) Killing normal Jacobi operator; A-isotropic; A-principal; complex hyperbolic quadric; complex quadric; cyclic parallel normal Jacobi operator; real Grassmannians of rank two; real hypersurfaces ⓘ ⓘ English 2021 2021-08 10.1007/s00025-021-01416-3 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ Reprogramming of tumor-associated macrophages to M1-like macrophages using M1 macrophage-derived exosomes engineered to target IL-4 receptor and enhance M1 polarization. ⓘ ⓘ Lee, Byungheon; Gunassekaran, Gowri Rangaswamy ⓘ Kyungpook Natl Univ, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ CANCER RESEARCH ⓘ CANCER RES ⓘ 0008-5472 1538-7445 81 13 SCIE ONCOLOGY ⓘ 2021 13.312 8.0 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-07 ⓘ 바로가기 바로가기
○ ○ Article ⓘ Robust and distributed neural representation of action values ⓘ Studies in rats, monkeys, and humans have found action-value signals in multiple regions of the brain. These findings suggest that action-value signals encoded in these brain structures bias choices toward higher expected rewards. However, previous estimates of action-value signals might have been inflated by serial correlations in neural activity and also by activity related to other decision variables. Here, we applied several statistical tests based on permutation and surrogate data to analyze neural activity recorded from the striatum, frontal cortex, and hippocampus. The results show that previously identified action-value signals in these brain areas cannot be entirely accounted for by concurrent serial correlations in neural activity and action value. We also found that neural activity related to action value is intermixed with signals related to other decision variables. Our findings provide strong evidence for broadly distributed neural signals related to action value throughout the brain. ⓘ Shin, Eun Ju; Jang, Yunsil; Kim, Soyoun; Kim, Hoseok; Cai, Xinying; Lee, Hyunjung; Sul, Jung Hoon; Lee, Sung-Hyun; Chung, Yeonseung; Lee, Daeyeol; Jung, Min Whan ⓘ Inst for Basic Sci Korea, Ctr Synapt Brain Dysfunct, Daejeon, South Korea; Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea; Inst Basic Sci, Ctr Neurosci Imaging Res, Suwon, South Korea; Karolinska Inst, Dept Neurosci, Biomed, Stockholm, Sweden; New York Univ Shanghai, NYU ECNU Inst Brain & Cognit Sci, NYU Shanghai, Shanghai, Peoples R China; East China Normal Univ, Sch Psychol & Cognit Sci, Shanghai Key Lab Brain Funct Genom, Minist Educ, Shanghai, Peoples R China; Kyungpook Natl Univ, Dept Anat, Sch Med, Daegu, South Korea; Ajou Univ, Neurosci Grad Program, Sch Med, Suwon, South Korea; Korea Adv Inst Sci & Technol, Dept Math Sci, Daejeon, South Korea; Johns Hopkins Univ, Zanvyl Krieger Mind Brain Inst, Kavli Neurosci Discovery Inst, Dept Neurosci, Baltimore, MD 21218 USA; Johns Hopkins Univ, Dept Psychol & Brain Sci, Baltimore, MD 21218 USA ⓘ Lee, Daeyeol/A-6794-2008; Cai, Xinying/G-2440-2012; Jung, Min Whan/GXF-5216-2022; Kim, Hyungcheol/AAK-1557-2021; Kim, Soyoun/A-2237-2010 ⓘ 57223396031; 56520843100; 52263771000; 57054250200; 37033590000; 55706786600; 6603153316; 56719004200; 54898647400; 7406660061; 7402549898 ⓘ daeyeol@jhu.edu;mwjung@kaist.ac.kr; ⓘ ELIFE ⓘ ELIFE ⓘ 2050-084X 10 SCIE BIOLOGY ⓘ 2021 8.713 8.0 0.81 2025-07-30 ⓘ 23 18 ⓘ TEMPORALLY DISCOUNTED VALUES; MEDIAL PREFRONTAL CORTEX; BASAL GANGLIA; REINFORCEMENT; STRIATUM; DORSAL; MODELS ⓘ ⓘ Action Potentials; Animals; Behavior, Animal; Brain; Choice Behavior; Corpus Striatum; Electroencephalography; Frontal Lobe; Haplorhini; Hippocampus; Humans; Maze Learning; Models, Statistical; Neural Pathways; Rats; Reinforcement, Psychology; Reward; Signal Processing, Computer-Assisted; Time Factors; article; autocorrelation; corpus striatum; frontal cortex; hippocampus; human; action potential; animal; animal behavior; brain; decision making; electroencephalography; frontal lobe; Haplorhini; maze test; nerve tract; physiology; rat; reward; signal processing; statistical model; time factor ⓘ English 2021 2021-04-20 10.7554/elife.53045 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Template-Directed Rapid Synthesis of Pd-Based Ultrathin Porous Intermetallic Nanosheets for Efficient Oxygen Reduction ⓘ Atomically ordered intermetallic nanoparticles exhibit improved catalytic activity and durability relative to random alloy counterparts. However, conventional methods with time-consuming and high-temperature syntheses only have rudimentary capability in controlling the structure of intermetallic nanoparticles, hindering advances of intermetallic nanocatalysts. We report a template-directed strategy for rapid synthesis of Pd-based (PdM, M=Pb, Sn and Cd) ultrathin porous intermetallic nanosheets (UPINs) with tunable sizes. This strategy uses preformed seeds, which act as the template to control the deposition of foreign atoms and the subsequent interatomic diffusion. Using the oxygen reduction reaction (ORR) as a model reaction, the as-synthesized Pd3Pb UPINs exhibit superior activity, durability, and methanol tolerance. The favored geometrical structure and interatomic interaction between Pd and Pb in Pd3Pb UPINs are concluded to account for the enhanced ORR performance. ⓘ Guo, Jingchun; Gao, Lei; Tan, Xin; Yuan, Yuliang; Kim, Jeonghyeon; Wang, Yu; Wang, Hui; Zeng, Yu-Jia; Choi, Sang-Il; Smith, Sean C.; Huang, Hongwen ⓘ Hunan Univ, Minist Educ, Adv Catalyt Engn Res Ctr, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China; Shenzhen Univ, Coll Phys & Optoelect Engn, Shenzhen 518060, Peoples R China; Australian Natl Univ, Res Sch Phys, Dept Appl Math, Integrated Mat Design Lab, Canberra, ACT 2601, Australia; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; West Anhui Univ, Dept Expt & Pract Teaching Management, Luan 237012, Anhui, Peoples R China ⓘ Choi, Sang-Il/AGR-1133-2022; Guo, Jing-Chun/AAH-5163-2020; Smith, Sean/H-5003-2015; Tan, Xin/HJA-4548-2022; Huang, Hongwen/AAD-6853-2020; Zeng, Yujia/F-5221-2016; Yuan, Yu/HTM-9814-2023; Guo, Jingchun/AAH-5163-2020; Gao, Lei/KFQ-7375-2024 ⓘ 57210998930; 57190169111; 57198744869; 57219088750; 57194560892; 57809585000; 57211368726; 13404537700; 56167600800; 7406649493; 55738280200 ⓘ huanghw@hnu.edu.cn; ⓘ ANGEWANDTE CHEMIE-INTERNATIONAL EDITION ⓘ ANGEW CHEM INT EDIT ⓘ 1433-7851 1521-3773 60 19 SCIE CHEMISTRY, MULTIDISCIPLINARY ⓘ 2021 16.823 8.1 6.19 2025-07-30 ⓘ 155 150 oxygen reduction reaction; palladium; porous intermetallic nanosheets; universal synthesis ⓘ ⓘ oxygen reduction reaction; palladium; porous intermetallic nanosheets; universal synthesis ⓘ Catalyst activity; Durability; Electrolytic reduction; Nanocatalysts; Nanoparticles; Nanosheets; Oxygen; Oxygen reduction reaction; Synthesis (chemical); Conventional methods; Geometrical structure; High-temperature synthesis; Interatomic interactions; Intermetallic nanoparticles; Methanol tolerance; Ordered intermetallic nanoparticles; Oxygen Reduction; Intermetallics ⓘ English 2021 2021-05-03 10.1002/anie.202100307 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Large Root Phenome Dataset Wide-Opened the Potential for Underground Breeding in Soybean ⓘ The root is the most critical plant organ for water and nutrient acquisition. Although the root is vital for water and nutrient uptake, the diverse root characters of soybean still need to be identified owing to the difficulty of root sampling. In this study, we used 150 wild and 50 cultivated soybean varieties to collect root image samples. We analyzed root morphological traits using acquired-image. Except for the main total length (MTL), the root morphological traits for most cultivated and wild plants were significantly different. According to correlation analysis, the wild and cultivated plants showed a significant correlation among total root length (TRL), projected area (PA), forks, total lateral length (TLL), link average diameter, and MTL. In particular, TRL was highly correlated with PA in both cultivated (0.92) and wild (0.82) plants compared with between MTL (0.43 for cultivated and 0.27 for wild) and TLL (0.82 for cultivated and 0.52 for wild). According to principal component analysis results, both plants could be separated; however, there was some overlap of the traits among the wild and cultivated individuals from some regions. Nevertheless, variation among the cultivated plants was higher than that found in the wild plants. Furthermore, three groups, including MTL, TLL, and the remaining traits, could explain all the variances. ⓘ Kim, Ki-Seung; Kim, Se-Hun; Kim, Jaeyoung; Tripathi, Pooja; Lee, Jeong-Dong; Chung, Yong Suk; Kim, Yoonha ⓘ FarmHannong Ltd, Dept Innovat Technol, Nonsan, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Jeju Natl Univ, Dept Plant Resources & Environm, Jeju, South Korea ⓘ Ghimire, Madhav/AAT-3026-2021; Chung, Yong/V-6909-2019 ⓘ 24463202100; 57217072245; 58060905400; 57215084745; 40462075100; 36983850100; 57224866763 ⓘ yschung@jejunu.ac.kr;kyh1229@knu.ac.kr; ⓘ FRONTIERS IN PLANT SCIENCE ⓘ FRONT PLANT SCI ⓘ 1664-462X 12 SCIE PLANT SCIENCES ⓘ 2021 6.627 8.2 0.64 2025-07-30 ⓘ 8 8 link average diameter; link average branching angle; phenomics; projected area; WinRHIZO ⓘ GLYCINE-SOJA SIEB.; IMAGE-ANALYSIS; WILD RELATIVES; TRAITS; GROWTH; SOIL; IDENTIFICATION; DIVERSITY ⓘ link average branching angle; link average diameter; phenomics; projected area; WinRHIZO ⓘ ⓘ English 2021 2021-08-05 10.3389/fpls.2021.704239 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Potential Role of Coumestrol in Soybean Leaf Senescence and Its Interaction With Phytohormones ⓘ Coumestrol is a natural organic compound synthesized in soy leaves and functions as a phytoalexin. The coumestrol levels in plants are reported to increase upon insect attack. This study investigates the correlation between coumestrol, senescence, and the effect of phytohormones on the coumestrol levels in soybean leaves. Our analysis involving high-performance liquid chromatography and 2-D gel electrophoresis indicated a significant difference in the biochemical composition of soybean leaves at various young and mature growth stages. Eight chemical compounds were specifically detected in young leaves (V1) only, whereas three different coumestans isotrifoliol, coumestrol, and phaseol were detected only in mature, yellow leaves of the R6 and R7 growth stage. MALDI-TOF-MS analysis was used to identify two proteins 3,9 -dihydroxypterocarpan 6A-monooxygenase (CYP93A1) and isoflavone reductase homolog 2 (IFR2) only in mature leaves, which are key components of the coumestrol biosynthetic pathway. This indicates that senescence in soybean is linked to the accumulation of coumestrol. Following the external application of coumestrol, the detached V1-stage young leaves turned yellow and showed an interesting development of roots at the base of the midrib. Additionally, the application of phytohormones, including SA, methyl jasmonate (MeJA), and ethephon alone and in various combinations induced yellowing within 5 days of the application with a concomitant significant increase in endogenous coumestrol accumulation. This was also accompanied by a significant increase in the expression of genes CYP81E28 (Gm08G089500), CYP81E22 (Gm16G149300), GmIFS1, and GmIFS2. These results indicate that various coumestans, especially coumestrol, accumulate during leaf maturity, or senescence in soybean. ⓘ Mun, Bong-Gyu; Kim, Hyun-Ho; Yuk, Heung Joo; Hussain, Adil; Loake, Gary John; Yun, Byung-Wook ⓘ Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Korea Inst Oriental Med KIOM, Herbal Med Res Div, Daejeon, South Korea; Abdul Wali Khan Univ, Dept Entomol, Mardan, Pakistan; Univ Edinburgh, Inst Mol Plant Sci, Edinburgh, Midlothian, Scotland ⓘ Yuk, Heung/T-5882-2019; Hussain, Dr. Adil/K-6016-2018; Mun, BongGyu/GYD-6010-2022 ⓘ 57147241300; 57194683295; 36969874600; 41961162600; 35583673400; 8245123600 ⓘ g.loake@ed.ac.uk;bwyun@knu.ac.kr; ⓘ FRONTIERS IN PLANT SCIENCE ⓘ FRONT PLANT SCI ⓘ 1664-462X 12 SCIE PLANT SCIENCES ⓘ 2021 6.627 8.2 0.83 2025-07-30 ⓘ 10 10 coumestans; coumestrol; phytohormones; soybean; senescence (leaf) ⓘ ACCUMULATION; PROTEINS; LEAVES; APHID ⓘ coumestans; coumestrol; phytohormones; senescence (leaf); soybean ⓘ ⓘ English 2021 2021-11-25 10.3389/fpls.2021.756308 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An Integrated Approach of QTL Mapping and Genome-Wide Association Analysis Identifies Candidate Genes for Phytophthora Blight Resistance in Sesame (Sesamum indicum L.) ⓘ Phytophthora blight (PB) caused by Phytophthora nicotianae is a highly destructive disease in sesame (Sesamum indicum L.). In this study, we used linkage mapping and genome-wide association study (GWAS) to identify quantitative trait loci (QTL) and candidate genes associated with PB resistance. The QTL mapping in 90 RILs of the Goenbaek x Osan cross using genotyping-by-sequencing detected significant QTLs for PB resistance on chromosome 10, explaining 12.79%-13.34% of phenotypic variation. Association of this locus to PB resistance was also revealed through bulked segregant analysis in second RIL population (Goenbaek x Milsung cross) comprising 188 RILs. The GWAS of 87 sesame accessions evaluated against three P. nicotianae isolates identified 29 SNPs on chromosome 10 significantly associated with PB resistance. These SNPs were located within a 0.79 Mb region, which co-located with the QTL intervals identified in RIL populations, and hence scanned for identifying candidate genes. This region contained several defense-related candidate R genes, five of which were selected for quantitative expression analysis. One of these genes, SIN₁₀₁₉₀₁₆ was found to show significantly higher expression in the resistant parent compared to that in the susceptible parents and selected RILs. Paired-end sequencing of the gene SIN₁₀₁₉₀₁₆ in parental cultivars revealed two synonymous SNPs between Goenbaek and Osan in exon 2 of coding DNA sequence. These results suggested SIN₁₀₁₉₀₁₆ as one of the candidate gene conferring PB resistance in sesame. The findings from this study will be useful in the marker-assisted selection as well as the functional analysis of PB resistance candidate gene(s) in sesame. ⓘ Asekova, Sovetgul; Oh, Eunyoung; Kulkarni, Krishnanand P.; Siddique, Muhammad Irfan; Lee, Myoung Hee; Kim, Jung In; Lee, Jeong-Dong; Kim, Minsu; Oh, Ki-Won; Ha, Tae-Joung; Kim, Sung-Up; Cho, Kwang-Soo ⓘ RDA, Dept Southern Area Crop Sci, Natl Inst Crop Sci, Miryang Si, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Seoul Natl Univ, Coll Agr & Life Sci, Plant Genom & Breeding Inst, Dept Plant Sci, Seoul, South Korea; Delaware State Univ, Dept Agr & Nat Resources, Dover, DE USA ⓘ ; Lee, Daesu/G-6407-2011; Siddique, Muhammad Irfan/AAC-3815-2019; Kulkarni, Krishnanand/AAA-5746-2021; Asekova, Sovetgul/AAD-7252-2022; Kim, Kyu/E-7814-2012 ⓘ 55886563800; 57204882790; 8241514400; 56104346200; 56142671500; 57204539161; 40462075100; 58635134600; 57209582322; 7203014297; 56016191300; 55722770800 ⓘ sesameup@korea.kr;kscholove@korea.kr; ⓘ FRONTIERS IN PLANT SCIENCE ⓘ FRONT PLANT SCI ⓘ 1664-462X 12 SCIE PLANT SCIENCES ⓘ 2021 6.627 8.2 2.11 2025-07-30 ⓘ 21 28 Sesame; Phytophthora blight; QTL; GBS; GWAS; qRT-PCR ⓘ RECOMBINATION ⓘ GBS; GWAS; Phytophthora blight; qRT-PCR; QTL; Sesame ⓘ ⓘ English 2021 2021-02-16 10.3389/fpls.2021.604709 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Characterization and Dynamics of Intracellular Gene Transfer in Plastid Genomes of Viola (Violaceae) and Order Malpighiales ⓘ Functional gene transfer from organelles to the nucleus, known as intracellular gene transfer (IGT), is an ongoing process in flowering plants. The complete plastid genomes (plastomes) of two Ulleung island endemic violets, Viola ulleungdoensis and V. woosanensis, were characterized, revealing a lack of the plastid-encoded infA, rpl32, and rps16 genes. In addition, functional replacement of the three plastid-encoded genes in the nucleus was confirmed within the genus Viola and the order Malpighiales. Three strategies for the acquisition of a novel transit peptide for successful IGT were identified in the genus Viola. Nuclear INFA acquired a novel transit peptide with very low identity between these proteins, whereas the nuclear RPL32 gene acquired an existing transit peptide via fusion with the nuclear-encoded plastid-targeted SOD gene (Cu-Zn superoxide dismutase superfamily) as one exon, and translated both proteins in the cytosol using alternative mRNA splicing. Nuclear RPS16 contains an internal transit peptide without an N-terminal extension. Gene loss or pseudogenization of the plastid-borne rpl32 and rps16 loci was inferred to occur in the common ancestor of the genus Viola based on an infrageneric phylogenetic framework in Korea. Although infA was lost in the common ancestor of the order Malpighiales, the rpl32 and rps16 genes were lost multiple times independently within the order. Our current study sheds additional light on plastid genome composition and IGT mechanisms in the violet genus and in the order Malpighiales. ⓘ Yang, JiYoung; Park, Seongjun; Gil, Hee-Young; Pak, Jae-Hong; Kim, Seung-Chul ⓘ Kyungpook Natl Univ, Res Inst Dok Do & Ulleung Do Isl, Daegu, South Korea; Yeungnam Univ, Inst Nat Sci, Gyongsan, South Korea; Korea Natl Arboretum, DMZ Bot Garden, Yanggu, South Korea; Kyungpook Natl Univ, Sch Life Sci, Dept Biol, BK21 KNU Creat BioRes Grp 4, Daegu, South Korea; Kyungpook Natl Univ, Dept Integrat Nat Sci East Sea Rim, Daegu, South Korea; Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea ⓘ Gil, Hee-Young/GVU-6007-2022; Park, Seongjun/KHE-4370-2024; Kim, Seung-Chul/AAR-6157-2020 ⓘ 55193226000; 56174240800; 55509374100; 7102232932; 57214983739 ⓘ jhpak@knu.ac.kr;sonchus96@skku.edu; ⓘ FRONTIERS IN PLANT SCIENCE ⓘ FRONT PLANT SCI ⓘ 1664-462X 12 SCIE PLANT SCIENCES ⓘ 2021 6.627 8.2 0.64 2025-07-30 ⓘ 10 9 intracellular gene transfer; Viola; infA; rpl32; rps16; Malpighiales ⓘ ACETYL-COA CARBOXYLASE; MULTIPLE SEQUENCE ALIGNMENT; CHLOROPLAST GENOME; INDEPENDENT TRANSFERS; NUCLEUS; EVOLUTION; DNA; SUBSTITUTION; EXPRESSION; ORGANELLES ⓘ infA; intracellular gene transfer; Malpighiales; rpl32; rps16; Viola ⓘ ⓘ English 2021 2021-08-27 10.3389/fpls.2021.678580 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Distributed associative memory network with memory refreshing loss ⓘ Despite recent progress in memory augmented neural network (MANN) research, associative memory networks with a single external memory still show limited performance on complex relational reasoning tasks. Especially the content-based addressable memory networks often fail to encode input data into rich enough representation for relational reasoning and this limits the relation modeling performance of MANN for long temporal sequence data. To address these problems, here we introduce a novel Distributed Associative Memory architecture (DAM) with Memory Refreshing Loss (MRL) which enhances the relation reasoning performance of MANN. Inspired by how the human brain works, our framework encodes data with distributed representation across multiple memory blocks and repeatedly refreshes the contents for enhanced memorization similar to the rehearsal process of the brain. For this procedure, we replace a single external memory with a set of multiple smaller associative memory blocks and update these sub-memory blocks simultaneously and independently for the distributed representation of input data. Moreover, we propose MRL which assists a task's target objective while learning relational information existing in data. MRL enables MANN to reinforce an association between input data and task objective by reproducing stochastically sampled input data from stored memory contents. With this procedure, MANN further enriches the stored representations with relational information. In experiments, we apply our approaches to Differential Neural Computer (DNC), which is one of the representative content-based addressing memory models and achieves the state-of-the-art performance on both memorization and relational reasoning tasks. (C) 2021 Elsevier Ltd. All rights reserved. ⓘ Park, Taewon; Choi, Inchul; Lee, Minho ⓘ Kyungpook Natl Univ, Dept Artificial Intelligence, 80 Daehak Ro, Daegu, South Korea; NEOALI, 80 Daehak Ro, Daegu, South Korea ⓘ ; Lee, Min-Ho/ABE-5735-2021 ⓘ 57219762271; 57212005248; 57191730119 ⓘ ptw7998@gmail.com;sharpic77@gmail.com;mholee@gmail.com; ⓘ NEURAL NETWORKS ⓘ NEURAL NETWORKS ⓘ 0893-6080 1879-2782 144 SCIE COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;NEUROSCIENCES ⓘ 2021 9.657 8.2 0.42 2025-07-30 ⓘ 6 7 Memory augmented neural network; Relational reasoning; Distributed representation; Auxiliary loss; Machine learning ⓘ NEURAL-NETWORKS; MAINTENANCE REHEARSAL; ITEM ⓘ Auxiliary loss; Distributed representation; Machine learning; Memory augmented neural network; Relational reasoning ⓘ Brain; Humans; Learning; Neural Networks, Computer; Associative storage; Encoding (symbols); Input output programs; Machine learning; Memory architecture; Associative memory networks; Auxiliary loss; Distributed associative memory; Distributed representation; External memory; Input datas; Memory augmented neural network; Neural-networks; Reasoning tasks; Relational reasoning; article; artificial neural network; associative memory; brain; human; human experiment; machine learning; reasoning; stochastic model; learning; Associative processing ⓘ English 2021 2021-12 10.1016/j.neunet.2021.07.030 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Drought Stress-Mediated Transcriptome Profile Reveals NCED as a Key Player Modulating Drought Tolerance in Populus davidiana ⓘ Populus trichocarpa has been studied as a model poplar species through biomolecular approaches and was the first tree species to be genome sequenced. In this study, we employed a high throughput RNA-sequencing (RNA-seq) mediated leaf transcriptome analysis to investigate the response of four different Populus davidiana cultivars to drought stress. Following the RNA-seq, we compared the transcriptome profiles and identified two differentially expressed genes (DEGs) with contrasting expression patterns in the drought-sensitive and tolerant groups, i.e., upregulated in the drought-tolerant P davidiana groups but downregulated in the sensitive group. Both these genes encode a 9-cis-epoxycarotenoid dioxygenase (NCED), a key enzyme required for abscisic acid (ABA) biosynthesis. The high-performance liquid chromatography (H PLC) measurements showed a significantly higher ABA accumulation in the cultivars of the drought-tolerant group following dehydration. The Arabidopsis nced3 loss-of-function mutants showed a significantly higher sensitivity to drought stress, similar to 90% of these plants died after 9 days of drought stress treatment. The real-time PCR analysis of several key genes indicated a strict regulation of drought stress at the transcriptional level in the P. davidiana drought-tolerant cultivars. The transgenic P. davidiana NCED3 overexpressing (OE) plants were significantly more tolerant to drought stress as compared with the NCED knock-down RNA interference (RNAi) lines. Further, the NCED OE plants accumulated a significantly higher quantity of ABA and exhibited strict regulation of drought stress at the transcriptional level. Furthermore, we identified several key differences in the amino acid sequence, predicted structure, and co-factor/ligand binding activity of NCED3 between drought-tolerant and susceptible P. davidiana cultivars. Here, we presented the first evidence of the significant role of NCED genes in regulating ABA-dependent drought stress responses in the forest tree P. davidiana and uncovered the molecular basis of NCED3 evolution associated with increased drought tolerance. ⓘ Lee, Sang-Uk; Mun, Bong-Gyu; Bae, Eun-Kyung; Kim, Jae-Young; Kim, Hyun-Ho; Shahid, Muhammad; Choi, Young-Im; Hussain, Adil; Yun, Byung-Wook ⓘ Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Natl Inst Forest Sci, Forest Microbiol Div, Suwon, South Korea; Agr Res Inst, Mingora, Swat, Pakistan; Natl Inst Forest Sci, Forest Biotechnol Div, Suwon, South Korea; Abdul Wali Khan Univ Mandan, Dept Agr, Mardan, Pakistan; Natl Forest Variety Ctr, Chungju Si, South Korea ⓘ Mun, BongGyu/GYD-6010-2022; Shahid, Muhammad/AAE-9424-2020; Kim, Dahee/IAM-6955-2023; Hussain, Dr. Adil/K-6016-2018; Hussain, Adil/K-6016-2018; Kim, Jae-Young/IUO-6466-2023 ⓘ 57203597131; 57147241300; 57206283539; 57205191453; 57194683295; 59577718600; 8967494600; 41961162600; 8245123600 ⓘ adilhussain@awkum.edu.pk;bwyun@knu.ac.kr; ⓘ FRONTIERS IN PLANT SCIENCE ⓘ FRONT PLANT SCI ⓘ 1664-462X 12 SCIE PLANT SCIENCES ⓘ 2021 6.627 8.2 2.11 2025-07-30 ⓘ 32 30 NCED3; NCED1; drought; Populus davidiana; ABA; transcriptome ⓘ ABSCISIC-ACID BIOSYNTHESIS; 9-CIS-EPOXYCAROTENOID DIOXYGENASE; WATER-STRESS; POPLAR; GENE; TRANSFORMATION; EXPRESSION; EFFICIENT; TOMATO; ABA ⓘ ABA; drought; NCED1; NCED3; Populus davidiana; transcriptome ⓘ ⓘ English 2021 2021-10-28 10.3389/fpls.2021.755539 ⓘ 바로가기 바로가기 바로가기 바로가기
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