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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Molybdenum nitride@porous carbon, derived from phosphomolybdic acid loaded metal-azolate framework-6: A highly effective catalyst for oxidative desulfurization A new composite of the metal-azolate framework (MAF-6) and phosphomolybdic acid (PMA), named PMA(x) @MAF-6, was prepared. Well-dispersed (size: similar to 4 nm) Mo2N, on porous carbon, was prepared without external nitrogen sources firstly via carbonization of the PMA(x)@MAF-6. The prepared catalyst was applied in oxidative desulfurization (ODS) with H2O2 as a greenoxidant and showed remarkable performance. A selected catalyst Mo2N@C-3 had the highest turnover frequency (30 h(-1), around 2-3 times of the best catalyst so far) with the lowest activation energy (27.8 kJ.mol(-1)) in ODS (with H2O2) among any molybdenum-based catalysts. The ODS over Mo2N@C was explained by a non-radical mechanism via active Mo-peroxo species. Moreover, the high activity of the catalyst is partly because of the contribution of nitrogen in Mo2N. The studied catalyst could be easily recycled by solvent washing. Therefore, Mo2N, especially supported on carbon (like Mo2N@C), could be firstly suggested as a promising catalyst in ODS. Mondol, Md Mahmudul Hassan; Bhadra, Biswa Nath; Jhung, Sung Hwa Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea Bhadra, Biswa/ABG-6935-2021; Bhadra, Biswa Nath/ABG-6935-2021; Jhung, Sung/AAO-6683-2021; Hassan Mondol, Md Mahmudul/AAM-8718-2021 57217989090; 56982844300; 6701659467 sung@knu.ac.kr; APPLIED CATALYSIS B-ENVIRONMENTAL APPL CATAL B-ENVIRON 0926-3373 1873-3883 288 SCIE CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL 2021 24.319 0.9 4.32 2025-07-30 88 89 Catalysis; Desulfurization; Metal-Organic frameworks; Molybdenum nitride; Oxidation ORGANIC FRAMEWORKS; IONIC LIQUIDS; MOO3 SUBNANOCLUSTERS; NANOPARTICLES; ADSORPTION; STRATEGY; FUELS; DEEP Catalysis; Desulfurization; Metal-Organic frameworks; Molybdenum nitride; Oxidation Activation energy; Carbon; Carbonization; Desulfurization; Hydrogen peroxide; Molybdenum compounds; Nitrogen; Porous materials; High activity; Molybdenum nitride; Nitrogen sources; Oxidative desulfurization; Phosphomolybdic acid; Radical mechanism; Turnover frequency; Well-dispersed; Catalyst activity English 2021 2021-07-05 10.1016/j.apcatb.2021.119988 바로가기 바로가기 바로가기 바로가기
Article Oxidative denitrogenation of liquid fuel over W2N@carbon catalyst derived from a phosphotungstinic acid encapsulated metal-azolate framework Tungsten nitride-incorporated carbon (W2N(x)@C) was firstly prepared via pyrolysis of a newly developed phosphotungstic acid-loaded metal-azolate framework-6, PTA(x)@MAF-6 s. The obtained (without ammonia feeding) W2N(x)@C materials, were utilized as catalysts for oxidative denitrogenation (ODN) of fuels. The W2N (x)@C materials, especially W2N(15)@C, under ultrasound (US) irradiation was found to be a very efficient catalyst for oxidative removal of various organo-nitrogen compounds (ONCs). Importantly, the W2N(15)@C showed around 80-147 times turnover frequency those of reported catalysts for stubborn carbazole oxidation. Electron density on the N-atom of the ONCs has a dominant role in the oxidation. The oxidation mechanism was suggested mainly based on the calculated electron density of the reactants and analysis of major intermediates/ products. Moreover, the US-assisted ODN was progressed by both non-radical and radical paths, as supported by the electron spin resonance and radical scavenger experiments. The recyclability of the catalyst in the US irradiative ODN was also confirmed. Bhadra, Biswa Nath; Baek, Yong Su; Kim, Sunghwan; Choi, Cheol Ho; Jhung, Sung Hwa Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea Bhadra, Biswa Nath/ABG-6935-2021; Kim, Sunghwan/HKN-9812-2023; Bhadra, Biswa/ABG-6935-2021; Jhung, Sung/AAO-6683-2021; Choi, Cheol Ho/AAA-4705-2020 56982844300; 57201976608; 57203772967; 7402958948; 6701659467 sung@knu.ac.kr; APPLIED CATALYSIS B-ENVIRONMENTAL APPL CATAL B-ENVIRON 0926-3373 1873-3883 285 SCIE CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL 2021 24.319 0.9 2.13 2025-07-30 47 50 Denitrogenation; Organo-nitrogen compounds; Oxidation; Tungsten nitride; Ultrasound ORGANIC FRAMEWORKS; ADSORPTIVE REMOVAL; NITROGEN-COMPOUNDS; VISIBLE-LIGHT; DESULFURIZATION; ULTRASOUND; OIL; DIBENZOTHIOPHENE; DESULFURIZATION/DENITRIFICATION; HYDRODESULFURIZATION Denitrogenation; Organo-nitrogen compounds; Oxidation; Tungsten nitride; Ultrasound Ammonia; Carbon; Electron density measurement; Electrons; Magnetic moments; Nitrogen removal; Oxidation; Reaction intermediates; Tungsten compounds; Efficient catalysts; Organo nitrogen compounds; Oxidation mechanisms; Oxidative denitrogenation; Oxidative removals; Phosphotungstic acid; Radical scavengers; Turnover frequency; Catalysts English 2021 2021-05-15 10.1016/j.apcatb.2020.119842 바로가기 바로가기 바로가기 바로가기
Article Reduced titania nanorods and Ni-Mo-S catalysts for photoelectrocatalytic water treatment and hydrogen production coupled with desalination This study presents a ternary hybrid solar desalination process coupled with photoelectrocatalytic water treatment and H-2 production in a single device. The desalination of brackish water in the desalination cell is initiated via photoinduced charge generation with a thermochemically reduced TiO2 nanorod array photoanode. The chlorides transferred to the neighboring anolyte at ion-transport efficiency of similar to 100% are photoelectrochemically transformed into reactive chlorine species responsible for the decomposition of urea into nitrate in the anolyte. Simultaneously, the H-2 production with a Ni-Mo-S (Ni2S3/MoS2) composite catalyst grown onto porous Ni substrate is achieved at Faradaic efficiency of similar to 90% in the catholyte concentrated with desalted Na+. Regardless of the operation condition, the H-2 energy contributes to the reduction in the energy consumption for desalination by 25%-30%. The overall ternary hybrid process is understood systematically, and the physiochemical properties and electrochemical behavior of the Ni-Mo-S catalysts are examined. Kim, Seonghun; Han, Dong Suk; Park, Hyunwoong Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar Park, Hyunwoong/A-1247-2012; Han, Dong SuK/AAX-9333-2021; Kim, Seonghun/Y-8178-2018 55854379300; 36139213900; 7601565583 hwp@knu.ac.kr; APPLIED CATALYSIS B-ENVIRONMENTAL APPL CATAL B-ENVIRON 0926-3373 1873-3883 284 SCIE CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL 2021 24.319 0.9 1.7 2025-07-30 42 40 Desalination; Photoelectrocatalyst; Electrocatalyst; Chlorine oxidation reaction; Hydrogen evolution reaction Chlorine oxidation reaction; Desalination; Electrocatalyst; Hydrogen evolution reaction; Photoelectrocatalyst Catalysts; Chlorine compounds; Desalination; Energy utilization; Hydrogen production; Nanorods; Oxide minerals; Substrates; Titanium dioxide; Urea; Composite catalysts; Electrochemical behaviors; Faradaic efficiencies; Operation conditions; Photoelectrocatalytic; Photoinduced charge generation; Physio-chemical properties; Solar desalination; Water treatment English 2021 2021-05-05 10.1016/j.apcatb.2020.119745 바로가기 바로가기 바로가기 바로가기
Article Standalone photoconversion of CO2 using Ti and TiOx-sandwiched heterojunction photocatalyst of CuO and CuFeO2 films Artificial photoconversion of carbon dioxide to value-added chemicals remains a challenge. In this work, we synthesize heterojunction copper oxide and copper iron oxide (CuO/CuFeO2; CFO) films on transparent con-ducting substrates with metallic Ti layers, and deposit disordered TiOx particles on the CFO films. The Ti/CFO/TiOx samples convert CO2 into formate with-100% selectivity and drive O-2 evolution under simulated sunlight in the absence of any electrical and chemical biases, achieving the overall solar-to-chemical energy conversion efficiency of-5%. The primary roles of the Ti underlayer are to create a robust contact between CFO and substrates and facilitate hole transfer. The TiOx (with unsaturated Ti atoms) delocalizes the electron density of the CFO and enhances electron transfer to the adsorbed CO2. Density functional theory calculations reveal that Ti/CFO/TiOx is the most suitable among the bare and modified CFO samples for efficient CO2 adsorption, for-miloxyl intermediate formation, and formate desorption. Choi, Seung Yo; Yoon, Sun Hee; Kang, Unseock; Han, Dong Suk; Park, Hyunwoong Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Texas A&M Univ Qatar, Petr Engn Program, Doha 23874, Qatar; Qatar Univ, Ctr Adv Mat, Doha 2713, Qatar Park, Hyunwoong/A-1247-2012; Han, Dong SuK/AAX-9333-2021 57200542080; 55516458500; 55682720300; 36139213900; 7601565583 hwp@knu.ac.kr; APPLIED CATALYSIS B-ENVIRONMENTAL APPL CATAL B-ENVIRON 0926-3373 1873-3883 288 SCIE CHEMISTRY, PHYSICAL;ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL 2021 24.319 0.9 0.88 2025-07-30 15 16 CO2 conversion; Metal oxides; Heterojunction; Photocatalysis; Formic acid CO<sub>2</sub> conversion; Formic acid; Heterojunction; Metal oxides; Photocatalysis Carbon dioxide; Conversion efficiency; Copper oxides; Density functional theory; Electron transport properties; Heterojunctions; Iron oxides; Oxide films; Solar energy; Chemical energy; CO2 adsorption; Conducting substrates; Electron transfer; Intermediate formation; Photoconversion; Simulated sunlight; Value-added chemicals; Titanium oxides English 2021 2021-07-05 10.1016/j.apcatb.2021.119985 바로가기 바로가기 바로가기 바로가기
Editorial Material Understanding what determines the organic solar cell stability Understanding the fundamental origin of morphological degradation in non-fullerene acceptor-based organic solar cells is challenging. In the April 2021 issue of Nature Materials, Ghasemi et al. reveal that the most thermodynamically unstable and low-miscibility systems with high Flory-Huggins interaction parameter (chi) exhibit the most kinetically stable (low diffusion) morphology for superior device operation stability under thermal stress. Cha, Hyojung; Wu, Jiaying Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea; Imperial Coll London, Dept Chem, London W12 0BZ, England; Imperial Coll London, Ctr Processable Elect, London W12 0BZ, England ; Wu, Jiaying/ABE-3868-2020 35885242200; 56911317800 hcha@knu.ac.kr; JOULE JOULE 2542-4351 5 6 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY 2021 46.048 0.9 1.19 2025-07-30 28 25 Device operations; Flory-Huggins interaction parameter; degradation; diffusion; environmental stress; fullerene; solar power; thermodynamics; Organic solar cells English 2021 2021-06-16 10.1016/j.joule.2021.05.020 바로가기 바로가기 바로가기 바로가기
Review Covalent organic framework-based materials: Synthesis, modification, and application in environmental remediation Covalent organic framework (COF) is a group of porous organic polymeric materials obtained from covalently attached organic building blocks. They exhibit positional control in two- or three-dimensional spaces through the predesigned and specified bonding of the monomer linkers. COFs are contemporary materials, and the recent identification of various synthesis and linking procedures has allowed their preparation with many advantageous properties and their usage in various applications. They can also be postsynthetically modified or converted to other materials of specific interest, thereby achieving materials with improved physical and chemical properties. COFs are considered as one of the most promising materials for applications in environmental remediation because of their ordered geometry, high porosity, functionality, high stability, and postsynthetic tunability in various physical and chemical forms. This review highlights the basic state-of-the-art in the advancement of stable COFs and their postsynthetic modification methods. The environmental remediation applications of COFs, which include adsorption, filtration, separation, catalysis, and sensing, will also be discussed in detail. Finally, the outcomes will be summarized and future directions will be discussed, indicating their promise for specialists in various research fields. (C) 2021 Elsevier B.V. All rights reserved. Ahmed, Imteaz; Jhung, Sung Hwa Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea Jhung, Sung/AAO-6683-2021 55377179600; 6701659467 sung@knu.ac.kr; COORDINATION CHEMISTRY REVIEWS COORDIN CHEM REV 0010-8545 1873-3840 441 SCIE CHEMISTRY, INORGANIC & NUCLEAR 2021 24.833 1.1 2.84 2025-07-30 144 148 Covalent organic frameworks; COF synthesis; Environmental remediation; Postsynthetic modification MIXED-MATRIX MEMBRANES; TRIAZINE-BASED FRAMEWORKS; ADSORPTIVE REMOVAL; IONIC LIQUIDS; CARBON-DIOXIDE; ENHANCED PERFORMANCE; SELECTIVE OXIDATION; RETICULAR SYNTHESIS; TARGETED SYNTHESIS; MESOPOROUS CARBON COF synthesis; Covalent organic frameworks; Environmental remediation; Postsynthetic modification English 2021 2021-08-15 10.1016/j.ccr.2021.213989 바로가기 바로가기 바로가기 바로가기
Article Enhanced compressive strength of rammed earth walls stabilized with eco-friendly multi-functional polymeric system This paper presents an efficient and eco-friendly soil stabilization method for binding the soil particles of rammed earth walls. The method uses a combination of a water-soluble acrylic acid-acrylic amide copolymer and an epoxy system containing a hardener. The results revealed that the unconfined compressive strength (UCS) of soil stabilized with the mixture of the copolymer and epoxy system was five times higher than that of soil treated with water and three times higher than that of stabilized soil (SS) with only the copolymer. The roles of the copolymer and epoxy system in UCS enhancement were determined based on morphology and apparent density (AD) and elucidated using proposed models. The soil stabilized with the copolymer and epoxy system exhibited the lowest AD and highest UCS. Further, its unique web-like morphology is consistent with the formation of an interpenetrating polymer network (IPN). The carboxylic and amide groups in the copolymer contribute to the formation of the IPN through interactions with the epoxy and amine groups of the hardener. The surface hydroxyl groups in the soil promote the coating of the polymer layer on the soil surface and the inter-particle cohesion, resulting in the formation of larger compacted lumps with a decreased AD and increased UCS. The hydrophilic copolymer acts as a stabilizer and plasticizer. The results confirmed that the epoxy system and copolymer significantly increased the UCS by forming an IPN. Thus, this study provides an efficient and ecofriendly water-soluble copolymer and epoxy system for enhancing the UCS of soil. Yoon, Keun-Byoung; Ryu, Hyun Min; Lee, Gwan Hui; Gopalan, Anantha Iyengar; Sai-anand, Gopalan; Lee, Dong-Eun KyungPook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; KyungPook Natl Univ, Intelligent Construct Automat Ctr, Daegu, South Korea; Univ Newcastle, Coll Engn Sci & Environm, Global Ctr Environm Remediat GCER, Callaghan, NSW 2308, Australia; KyungPook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 1370 Sangyegk Dong, Daegu 702701, South Korea Gopalan, Saianand/J-6000-2019 7401607550; 57254125300; 57201689364; 57191999779; 38362265400; 56605563300 dolee@knu.ac.kr; RENEWABLE & SUSTAINABLE ENERGY REVIEWS RENEW SUST ENERG REV 1364-0321 1879-0690 152 SCIE ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY 2021 16.799 1.1 0.29 2025-07-30 8 8 Rammed earth wall; Rammed earth method; Soil stabilization; Eco-friendliness; Multi-functional polymeric; Copolymer; Epoxy DOUBLE-NETWORK HYDROGELS; SOIL; BEHAVIOR; EPOXY; CLAY; FIBERS; POLYACRYLAMIDE; REINFORCEMENT; ARCHITECTURE; IMPROVEMENT Copolymer; Eco-friendliness; Epoxy; Multi-functional polymeric; Rammed earth method; Rammed earth wall; Soil stabilization Compressive strength; Morphology; Soil mechanics; Soils; Water treatment; Eco-friendliness; Epoxy; Epoxy systems; Multi-functional; Multi-functional polymeric; Rammed earth; Rammed earth method; Rammed earth walls; Soil stabilization; Unconfined compressive strength; Stabilization English 2021 2021-12 10.1016/j.rser.2021.111681 바로가기 바로가기 바로가기 바로가기
Article NTRK and RET fusion-directed therapy in pediatric thyroid cancer yields a tumor response and radioiodine uptake BACKGROUND. Molecular characterization in pediatric papillary thyroid cancer (PTC), distinct from adult PTC, is important for developing molecularly targeted therapies for progressive radioiodine-refractory (I-131-refractory) PTC. METHODS. PTC samples from 106 pediatric patients (age range: 4.3-19.8 years; n = 84 girls, n = 22 boys) who were admitted to SNUH (January 1983-March 2020) were available for genomic profiling. Previous transcriptomic data from 125 adult PTC samples were used for comparison. RESULTS. We identified genetic drivers in 80 tumors: 31 with fusion oncogenes (RET in 21 patients, ALK in 6 patients, and NTRK1/3 in 4 patients); 47 with point mutations (BRAF(V600E) in 41 patients, TERTC228T in 2 patients [1 of whom had a coexisting BRAF(V600E)], and DICER1 variants in 5 patients); and 2 with amplifications. Fusion oncogene PTCs, which are predominantly detected in younger patients, were at a more advanced stage and showed more recurrent or persistent disease compared with BRAF(V600E) PTCs, which are detected mostly in adolescents. Pediatric fusion PTCs (in patients <10 years of age) had lower expression of thyroid differentiation genes, including SLC5A5, than did adult fusion PTCs. Two girls with progressive I-131-refractory lung metastases harboring a TPR-NTRK1 or CCDC6-RET fusion oncogene received fusion-targeted therapy; larotrectinib and selpercatinib decreased the size of the tumor and restored I-125 radioiodine uptake. The girl with the CCDC6-RET fusion oncogene received I-131 therapy combined with selpercatinib, resulting in a tumor response. In vitro I-125 uptake and I-131 clonogenic assays showed that larotrectinib inhibited tumor growth and restored radioiodine avidity. CONCLUSIONS. In pediatric patients with fusion oncogene PTC who have I-131-refractory advanced disease, selective fusion-directed therapy may restore radioiodine avidity and lead to a dramatic tumor response, underscoring the importance of molecular testing in pediatric patients with PTC. Lee, Young Ah; Lee, Hyunjung; Im, Sun-Wha; Song, Young Shin; Oh, Do-Youn; Kang, Hyoung Jin; Won, Jae-Kyung; Jung, Kyeong Cheon; Kwon, Dohee; Chung, Eun-Jae; Hah, J. Hun; Paeng, Jin Chul; Kim, Ji-hoon; Choi, Jaeyong; Kim, Ok-Hee; Oh, Ji Min; Ahn, Byeong-Cheol; Wirth, Lori J.; Shin, Choong Ho; Kim, Jong-Il; Park, Young Joo Seoul Natl Univ, Childrens Hosp, Dept Pediat, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Biomed Sci, Grad Sch, 103 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ, Genom Med Inst, Med Res Ctr, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Biochem & Mol Biol, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 03080, South Korea; Seoul Natl Univ Hosp SNUH, Dept Internal Med, Med Oncol, Seoul, South Korea; Seoul Natl Univ, Canc Res Inst, Seoul, South Korea; Seoul Natl Univ, Integrated Major Innovat Med Sci, Grad Sch, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Pathol, SNUH, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Otorhinolaryngol Head & Neck Surg, SNUH, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Nucl Med, SNUH, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Radiol, SNUH, Seoul, South Korea; Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Coll Med, Incheon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea ; KIM, JONG-IL/D-1019-2011; Lee, WonJae/K-1296-2016; Hah, Jeong/A-6084-2015; Park, Young/J-4161-2012; Hah, J. Hun/A-6084-2015 35215266500; 57225156352; 35279614400; 57206834282; 8836932000; 7404071502; 11241572800; 35248055000; 57189027712; 36810155000; 7003942217; 6602895031; 55760887500; 57214603982; 36463666400; 57190370462; 7202791511; 6701692419; 8505197600; 56016185900; 57049715800 jongil@snu.ac.kr;yjparkmd@snu.ac.kr; JOURNAL OF CLINICAL INVESTIGATION J CLIN INVEST 0021-9738 1558-8238 131 18 SCIE MEDICINE, RESEARCH & EXPERIMENTAL 2021 19.477 1.1 9.06 2025-07-30 103 99 TERT PROMOTER MUTATIONS; MOLECULAR-GENETICS; ONCOGENES; BRAF; LAROTRECTINIB; CARCINOMA; DIAGNOSIS; CHILDREN; EFFICACY Adolescent; Age Factors; Child; Child, Preschool; Combined Modality Therapy; Female; Humans; Iodine Radioisotopes; Male; Molecular Targeted Therapy; Oncogene Proteins, Fusion; Proto-Oncogene Proteins c-ret; Pyrazoles; Pyridines; Pyrimidines; Radiopharmaceuticals; Receptor, trkA; Thyroid Cancer, Papillary; Thyroid Neoplasms; Transcriptome; Young Adult; anaplastic lymphoma kinase; B Raf kinase; dicer; epidermal growth factor receptor; fibroblast growth factor receptor 1; iodine 125; iodine 131; K ras protein; larotrectinib; radioactive iodine; Ras protein; selpercatinib; telomerase reverse transcriptase; thyroglobulin; Iodine-125; Iodine-131; larotrectinib; NTRK1 protein, human; oncoprotein; protein Ret; protein tyrosine kinase A; pyrazole derivative; pyridine derivative; pyrimidine derivative; radioactive iodine; radiopharmaceutical agent; RET protein, human; selpercatinib; transcriptome; adolescent; adult; advanced cancer; Article; cancer inhibition; cancer staging; cancer survival; CCDC6 RET gene fusion; child; clonogenic assay; differentiated thyroid cancer; distant metastasis; drug megadose; drug uptake; female; follow up; gene expression; gene expression level; gene expression profiling; gene fusion; heterozygosity loss; human; human cell; human tissue; in vitro study; lung metastasis; lymph node metastasis; major clinical study; male; MAPK signaling; molecularly targeted therapy; NTRK1 gene; NTRK3 gene; oncogene H ras; oncogene N ras; patient history of radiotherapy; pediatric patient; point mutation; poorly differentiated thyroid cancer; preschool child; recurrence free survival; school child; SLC5A5 gene; thyroglobulin blood level; thyroid papillary carcinoma; thyroidectomy; TPR NTRK1 gene fusion; treatment response; whole genome sequencing; young adult; age; genetics; multimodality cancer therapy; procedures; thyroid tumor English 2021 2021-09-15 10.1172/jci144847 바로가기 바로가기 바로가기 바로가기
Article Proposal of demolished concrete recycling system based on performance evaluation of inorganic building materials manufactured from waste concrete powder The rapid industrial development and global population growth of the past century have resulted in an exponential increase of resource consumption and thus caused elevated CO2 emissions that, in turn, are held responsible for global warming and associated environmental problems that require urgent solutions. Specifically, increase of cement production causes CO2 pollution and generates a significant amount of concrete waste. Waste concrete, the major component of construction waste, can be efficiently recycled and is mainly used as a roadbed or backfill material. However, as no further resource recycling is expected for waste concrete, more efficient and productive recycling systems are sought after. Herein, waste concrete powder is used to produce added-value inorganic building materials, namely recycled cement and solidification. The characteristics of recycled cement (manufactured through calcination) are evaluated in terms of free lime content, mineral composition, density, color, flow test and strength, and the performance of recycled cement is found to be identical to that of ordinary Portland cement. X-ray diffraction and compressive strength analyses of the solidification manufactured through hydrothermal synthesis show that blocks of the desired strengths can be produced by adjusting the degree of consolidation and curing conditions. Based on these results, this study proposes a concrete waste recycling system to reduce the amount of construction waste and prevent resource depletion. Oh, Dayoung; Noguchi, Takafumi; Kitagaki, Ryoma; Choi, Hyeonggil Univ Tokyo, Dept Architecture, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138685, Japan; Hokkaido Univ, Grad Sch Engn, Nishi 8 Chome,Kita 13 Jyo, Sapporo, Hokkaido 0608628, Japan; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehakro, Daegu 41566, South Korea 56296722600; 7402340025; 37088734200; 56430165800 hgchoi@knu.ac.kr; RENEWABLE & SUSTAINABLE ENERGY REVIEWS RENEW SUST ENERG REV 1364-0321 1879-0690 135 SCIE ENERGY & FUELS;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY 2021 16.799 1.1 1.47 2025-07-30 40 42 Waste concrete powder; Inorganic building material; Recycled cement; Hydrothermal synthesis; Tobermorite; Demolished concrete; Recycling system COAL FLY-ASH; DICALCIUM SILICATE; MECHANICAL-PROPERTIES; AGGREGATE; SOLIDIFICATION; CEMENT Demolished concrete; Hydrothermal synthesis; Inorganic building material; Recycled cement; Recycling system; Tobermorite; Waste concrete powder Carbon dioxide; Compressive strength; Concretes; Global warming; Hydrothermal synthesis; Industrial emissions; Lime; Population statistics; Portland cement; Recycling; Buildings materials; Concrete wastes; Demolished concretes; Inorganic building material; Inorganics; Recycled cements; Recycling systems; Tobermorite; Waste concrete; Waste concrete powder; Solidification English 2021 2021-01 10.1016/j.rser.2020.110147 바로가기 바로가기 바로가기 바로가기
Review Recent advances in process engineering and upcoming applications of metal-organic frameworks Progress in metal-organic frameworks (MOFs) has advanced from fundamental chemistry to engineering processes and applications, resulting in new industrial opportunities. The unique features of MOFs, such as their permanent porosity, high surface area, and structural flexibility, continue to draw industrial interest outside the traditional MOF field, both to solve existing challenges and to create new businesses. In this context, diverse research has been directed toward commercializing MOFs, but such studies have been performed according to a variety of individual goals. Therefore, there have been limited opportunities to share the challenges, goals, and findings with most of the MOF field. In this review, we examine the issues and demands for MOF commercialization and investigate recent advances in MOF process engineering and applications. Specifically, we discuss the criteria for MOF commercialization from the views of stability, producibility, regulations, and production cost. This review covers progress in the mass production and formation of MOFs along with future applications that are not currently well known but have high potential for new areas of MOF commercialization. (C) 2020 Elsevier B.V. All rights reserved. Ryu, UnJin; Jee, Seohyeon; Rao, Purna Chandra; Shin, Jeeyoung; Ko, Changhyun; Yoon, Minyoung; Park, Kyo Sung; Choi, Kyung Min Sookmyung Womens Univ, Dept Chem & Biol Engn, 100 Cheongpa Ro 47 Gil, Seoul 04310, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Sookmyung Womens Univ, Dept Mech Syst Engn, Seoul 04310, South Korea; Sookmyung Womens Univ, Inst Adv Mat & Syst, 100 Cheongpa Ro 47 Gil, Seoul 04310, South Korea; Sookmyung Womens Univ, Coll Engn, Dept Appl Phys, Seoul 04310, South Korea; LG Chem, Corp R&D, Res Pk,LG Sci Pk,30,Magokjungang 10 Ro, Seoul, South Korea Park, Kyo Sung/G-5804-2011; RAO, PURNA CHANDRA/T-7112-2017; Rao, Purna Chandra/AHI-3532-2022; Jee, Seohyeon/AAE-1683-2019 57193847547; 57201984156; 56378818800; 7402724064; 55738847800; 25222186500; 7408066919; 55659485400 myyoon@knu.ac.kr;kyosungp@lgchem.com;kmchoi@sookmyung.ac.kr; COORDINATION CHEMISTRY REVIEWS COORDIN CHEM REV 0010-8545 1873-3840 426 SCIE CHEMISTRY, INORGANIC & NUCLEAR 2021 24.833 1.1 6.94 2025-07-30 322 326 Metal-organic framework; Commercialization; Mass production; Future applications; Shaping; Dispersion MICROWAVE-ASSISTED SYNTHESIS; ROOM-TEMPERATURE SYNTHESIS; CRYSTALLINE POROUS MATERIALS; SOLID-STATE ELECTROLYTES; SPACE-TIME-YIELD; HYDROGEN STORAGE; MECHANOCHEMICAL SYNTHESIS; ENERGY-STORAGE; COORDINATION POLYMER; SELECTIVE ADSORPTION Commercialization; Dispersion; Future applications; Mass production; Metal–organic framework; Shaping English 2021 2021-01-01 10.1016/j.ccr.2020.213544 바로가기 바로가기 바로가기 바로가기
Article Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation Reactive oxygen signaling regulates numerous biological processes, including stress responses in plants. Redox sensors transduce reactive oxygen signals into cellular responses. Here, we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog (QSOX1) is a redox sensor that negatively regulates plant immunity against a bacterial pathogen. The expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species (ROS) accumulation. Interestingly, QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase, which, consistent with previous findings, influences reactive nitrogen-mediated regulation of ROS generation. Collectively, our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production. Chae, Ho Byoung; Kim, Min Gab; Kang, Chang Ho; Park, Joung Hun; Lee, Eun Seon; Lee, Sang-Uk; Chi, Yong Hun; Paeng, Seol Ki; Bae, Su Bin; Wi, Seong Dong; Yun, Byung-Wook; Kim, Woe-Yeon; Yun, Dae-Jin; Mackey, David; Lee, Sang Yeol Gyeongsang Natl Univ, Div Appl Life Sci BK21, Jinju 52828, South Korea; Gyeongsang Natl Univ, PMBBRC, Jinju 52828, South Korea; Gyeongsang Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Jinju 52828, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Appl Biosci, Daegu 41566, South Korea; Konkuk Univ, Dept Biomed Sci & Engn, Seoul 05029, South Korea; Ohio State Univ, Dept Hort & Crop Sci, Dept Mol Genet, Columbus, OH 43210 USA; Ohio State Univ, Ctr Appl Plant Sci, Columbus, OH 43210 USA; Qingdao Agr Univ, Coll Life Sci, Qingdao 266109, Peoples R China; Sejong Natl Arboretum, Plant Prod Div, Plant Propagat Team, Sejong 30106, Peoples R China Lee, Sang/S-5752-2019 57213879835; 57218318463; 55904559400; 55337419400; 42361286200; 57203597131; 7103206732; 42361541800; 57209693327; 57197865556; 8245123600; 7405813205; 35228284000; 7102699826; 57202883792 mackey.86@osu.edu;sylee@gnu.ac.kr; MOLECULAR PLANT MOL PLANT 1674-2052 1752-9867 14 8 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES 2021 21.949 1.1 3.06 2025-07-30 46 45 redox sensor; plant immunity; QSOX1; GSNOR; reactive oxygen species (ROS); reactive nitrogen species (RNS) DISULFIDE BOND FORMATION; NADPH OXIDASE RBOHD; REACTIVE OXYGEN; S-NITROSYLATION; NITRIC-OXIDE; ASCORBATE PEROXIDASE; SULFHYDRYL OXIDASE; ARABIDOPSIS-THALIANA; SEED-GERMINATION; SALICYLIC-ACID GSNOR; plant immunity; QSOX1; reactive nitrogen species (RNS); reactive oxygen species (ROS); redox sensor Aldehyde Oxidoreductases; Biological Phenomena; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Plant Immunity; Plants; Reactive Oxygen Species; Signal Transduction; aldehyde dehydrogenase; formaldehyde dehydrogenase, glutathione-independent; oxidoreductase; reactive oxygen metabolite; cellular, subcellular and molecular biological phenomena and functions; genetics; immunology; metabolism; oxidation reduction reaction; plant; plant immunity; signal transduction English 2021 2021-08-02 10.1016/j.molp.2021.05.004 바로가기 바로가기 바로가기 바로가기
Article RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse Slow-cycling/dormant cancer cells (SCCs) have pivotal roles in driving cancer relapse and drug resistance. A mechanistic explanation for cancer cell dormancy and therapeutic strategies targeting SCCs are necessary to improve patient prognosis, but are limited because of technical challenges to obtaining SCCs. Here, by applying proliferation-sensitive dyes and chemotherapeutics to non-small cell lung cancer (NSCLC) cell lines and patient-derived xenografts, we identified a distinct SCC subpopulation that resembled SCCs in patient tumors. These SCCs displayed major dormancy-like phenotypes and high survival capacity under hostile microenvironments through transcriptional upregulation of regulator of G protein signaling 2 (RGS2). Database analysis revealed RGS2 as a biomarker of retarded proliferation and poor prognosis in NSCLC. We showed that RGS2 caused prolonged translational arrest in SCCs through persistent eukaryotic initiation factor 2 (eIF2 alpha) phosphorylation via proteasome-mediated degradation of activating transcription factor 4 (ATF4). Translational activation through RGS2 antagonism or the use of phosphodiesterase S inhibitors, including sildenafil (Viagra), promoted ER stress-induced apoptosis in SCCs in vitro and in vivo under stressed conditions, such as those induced by chemotherapy. Our results suggest that a low-dose chemotherapy and translation-instigating pharmacological intervention in combination is an effective strategy to prevent tumor progression in NSCLC patients after rigorous chemotherapy. Cho, Jaebeom; Min, Hye-Young; Lee, Ho Jin; Hyun, Seung Yeob; Sim, Jeong Yeon; Noh, Myungkyung; Hwang, Su Jung; Park, Shin-Hyung; Boo, Hye-Jin; Lee, Hyo-Jong; Hong, Sungyoul; Park, Rang-Woon; Shin, Young Kee; Hung, Mien-Chie; Lee, Ho-Young Seoul Natl Univ, Coll Pharm, Creat Res Initiat Ctr Concurrent Control Emphysem, 1 Gwanak Ro, Seoul 08826, South Korea; Seoul Natl Univ, Coll Pharm, Seoul, South Korea; Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea; Inje Univ, Coll Pharm, Gimhae, Gyungnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu, South Korea; China Med Univ, Res Ctr Canc Biol, Grad Inst Biomed Sci, Taichung, Taiwan; China Med Univ, Ctr Mol Med, Taichung, Taiwan; Asia Univ, Dept Biotechnol, Taichung, Taiwan; Sungkyunkwan Univ, Sch Pharm, Suwon, Gyeonggi Do, South Korea; Dong Eui Univ, Dept Pathol, Coll Korean Med, Busan, South Korea ; Hung, Mien-Chie/ABD-5911-2021; Park, Shin-Hyung/O-3803-2015; Lee, Sun-Ho/AAD-6712-2022; Shin, Young/C-8929-2011; Lee, hojin/GXZ-4764-2022; Lee, Jongseung/AER-7002-2022 56783383900; 56564751200; 57205720453; 56564795100; 57217038477; 56443677300; 55908888300; 54389880900; 35482970400; 57092922800; 35082143500; 7401895636; 26428533000; 57221330685; 57049822900; 59283094500 hylee135@snu.ac.kr; JOURNAL OF CLINICAL INVESTIGATION J CLIN INVEST 0021-9738 1558-8238 131 1 SCIE MEDICINE, RESEARCH & EXPERIMENTAL 2021 19.477 1.1 3.67 2025-07-30 40 38 UNFOLDED PROTEIN RESPONSE; ER-STRESS; LUNG-CANCER; RGS2; MECHANISMS; EXPRESSION; CHEMOTHERAPY; RESISTANCE; SILDENAFIL; REGULATOR Animals; Carcinoma, Non-Small-Cell Lung; Female; Humans; Lung Neoplasms; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasm Proteins; Protein Biosynthesis; Recurrence; RGS Proteins; Xenograft Model Antitumor Assays; acetylcysteine; activating transcription factor 4; antineoplastic agent; benzyloxycarbonylleucylleucylleucinal; cisplatin; cycloheximide; dye; etoposide; initiation factor 2; initiation factor 2alpha; paclitaxel; proteasome; rapamycin; RGS2 protein; sildenafil; small interfering RNA; tadalafil; thapsigargin; tumor marker; RGS protein; RGS2 protein, human; tumor protein; animal experiment; animal model; antitumorigenic activity; apoptosis; Article; cancer chemotherapy; cancer patient; cancer prognosis; cancer tissue; cell proliferation; cell subpopulation; chemosensitivity; controlled study; dormancy; drug formulation; endoplasmic reticulum stress; female; gene delivery system; human; human cell; human tissue; in vitro study; in vivo study; lung non-small cell carcinoma cell line; mouse; non small cell lung cancer; nonhuman; phenotype; priority journal; protein database; protein degradation; protein synthesis; receptor upregulation; tumor growth; tumor recurrence; tumor xenograft; animal; drug screening; genetics; lung tumor; metabolism; non small cell lung cancer; nonobese diabetic mouse; pathology; protein synthesis; recurrent disease; SCID mouse English 2021 2021-01-04 10.1172/jci136779 바로가기 바로가기 바로가기 바로가기
Article Stochastic resource leveling optimization method for trading off float consumption and project completion probability Existing resource leveling (RL) approaches fall short of analyzing the trade-off relation between the total float consumption and project completion probability in a real-life project RL problem. This article presents a stochastic resource leveling optimization (SOLO) method that minimizes the total float consumption along with maximizing the project completion probability. It initializes the earliest start times of noncritical activities, measures the level of resource fluctuations of each candidate solution, computes the probability of completing a project in a target deadline by executing simulation-based scheduling, and identifies optimal solution(s) (i.e., optimal start times of noncritical activities) by implementing genetic algorithm, thereby identifying an optimal resource-leveled baseline. The study is of value to practitioners because SOLO considers both the amount of total float consumption and project completion probability. This study facilitates experimentation with different computation time-saving options given various constraints (i.e., the residual of project completion probabilities, threshold of release and rehire, ratio of criticality index, and number of critical activities). Test cases verify the validity of the computational method. Gwak, Han-Seong; Lee, Dong-Eun Kyungpook Natl Univ, Intelligent Construct Automat Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, 1370 Sangyegk Dong, Daegu 702701, South Korea Gwak, Hanseong/AAW-6131-2021 56800359900; 56605563300 dolee@knu.ac.kr; COMPUTER-AIDED CIVIL AND INFRASTRUCTURE ENGINEERING COMPUT-AIDED CIV INF 1093-9687 1467-8667 36 8 SCIE COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;TRANSPORTATION SCIENCE & TECHNOLOGY 2021 10.066 1.1 0.42 2025-07-30 4 6 Economic and social effects; Genetic algorithms; Stochastic systems; Computation time; Critical activities; Optimal solutions; Optimization method; Project completion; Resource leveling; Test case; Trade off; leveling; numerical method; optimization; project management; stochasticity; trade-off; Probability English 2021 2021-08 10.1111/mice.12668 바로가기 바로가기 바로가기 바로가기
Review Direct Comparison of Preoperative Imaging Modalities for Localization of Primary Hyperparathyroidism A Systematic Review and Network Meta-analysis IMPORTANCE Accurate preoperative localization of primary hyperparathyroidism (pHPT) is an important and challenging issue for a successful parathyroidectomy. Although new imaging modalities have been introduced during the past decade, direct comparative studies on advanced imaging techniques are limited. OBJECTIVE To compare the performance of different preoperative imaging modalities for the localization of pHPT by performing a network meta-analysis (NMA). DATA SOURCES PubMed, Embase, and the Cochrane Library were searched from the earliest available indexing date through September 28, 2020. STUDY SELECTION The inclusion criteria were diagnostic tests with sensitivities of 2 or more different preoperative imaging modalities for the same indivduals. DATA EXTRACTION AND SYNTHESIS Two researchers independently reviewed the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension statement of health care intervention guidelines for network meta-analyses. MAIN OUTCOMES AND MEASURES After classifying various imaging modalities into 8 representative imaging categories, the pooled estimation between the odds ratio and 95% credible intervals (CrIs) was calculated in the sensitivity for localization of pHPT. The surface under the cumulative ranking curve (SUCRA) values were obtained to calculate the probability of each imaging modality being the most effective diagnostic method. RESULTS A total of 8495 patients from 119 direct comparative studies using 2 or more imaging modalities for localization of pHPT were included. The sensitivity of choline positron emission tomography and computed tomography (PET-CT) was significantly higher than that of technetium 99m sestamibi single-photon emission computed tomography (MIBI SPECT) in both patient-based and lesion-based analyses (patient-based analysis: odds ratio, 5.22; 95% CrI, 2.36-11.80; lesion-based analysis: odds ratio, 17.70; 95% CrI, 5.79-60.10). Among 8 representative imaging modality categories, choline PET-CT showed the highest SUCRA value in both patient-based and lesion-based analyses. In patient-based analysis after 2010, choline PET-CT showed the highest SUCRA value, followed by the CT category, although MIBI SPECT had the highest SUCRA value in analysis before 2009. CONCLUSIONS AND RELEVANCE The results from this network meta-analysis suggest that choline PET-CT showed the best performance in both patient-based and lesion-based analyses and that choline PET-CT would be the best preoperative imaging modality for localization of pHPT. Lee, Sang-Woo; Shim, Sung Ryul; Jeong, Shin Young; Kim, Seong-Jang Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Korea Univ, Coll Med, Dept Prevent Med, Seoul, South Korea; Pusan Natl Univ, Yangsan Hosp, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, Coll Med, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea shim, sungryul/D-3792-2016; Kim, Yun Hak/ABF-3331-2021; lee, sangwoo/KUD-1906-2024 57196249819; 55072270800; 36164032500; 35810391700 growthkim@daum.net; JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY JAMA OTOLARYNGOL 2168-6181 2168-619X 147 8 SCIE OTORHINOLARYNGOLOGY;SURGERY 2021 8.961 1.2 3.29 2025-07-30 42 43 HIGH-RESOLUTION ULTRASONOGRAPHY; MINIMALLY INVASIVE PARATHYROIDECTOMY; TC-99M SESTAMIBI SCINTIGRAPHY; EMISSION COMPUTED-TOMOGRAPHY; SURGEON-PERFORMED ULTRASOUND; SUBTRACTION SCINTIGRAPHY; TC-99M-SESTAMIBI SCINTIGRAPHY; DOUBLE-PHASE; DUAL-TRACER; TECHNETIUM-99M-SESTAMIBI SCINTIGRAPHY (3 iodobenzyl)guanidine i 123; choline; methoxy isobutyl isonitrile technetium tc 99m; pertechnetic acid tc 99m; tetrofosmin tc 99m; adult; diagnostic accuracy; diagnostic imaging; echography; four dimensional computed tomography; human; incidental finding; intermethod comparison; meta analysis; network meta-analysis; parathyroid adenoma; positron emission tomography-computed tomography; practice guideline; preoperative evaluation; primary hyperparathyroidism; Review; single photon emission computed tomography; single photon emission computed tomography-computed tomography; systematic review English 2021 2021-08 10.1001/jamaoto.2021.0915 바로가기 바로가기 바로가기 바로가기
Letter Nusinersen in spinal muscular atrophy type 1 from neonates to young adult: 1-year data from three Asia-Pacific regions Chan, Sophelia Hoi-Shan; Chae, Jong-Hee; Chien, Yin-Hsiu; Ko, Tae-Sung; Lee, Jee Hun; Lee, Yun Jeong; Nam, Sang Ook; Jong, Yuh-Jyh Univ Hong Kong, Queen Mary Hosp, Dept Paediat & Adolescent Med, Hong Kong, Peoples R China; Seoul Natl Univ, Coll Med, Childrens Hosp, Dept Pediat, Seoul, South Korea; Seoul Natl Univ Hosp, Rare Dis Ctr, Seoul, South Korea; Natl Taiwan Univ Hosp, Dept Med Genet & Pediat, Taipei, Taiwan; Univ Ulsan, Coll Med, Childrens Hosp, Dept Pediat,Asan Med Ctr, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea; Kyungpook Natl Univ, Coll Med, Kyungpook Natl Univ Hosp, Dept Pediat, Daegu, South Korea; Pusan Natl Univ, Coll Med, Childrens Hosp, Dept Pediat, Yangsan, South Korea; Kaohsiung Med Univ, Kaohsiung Univ Med Hosp, Dept Pediat, Kaohsiung, Taiwan; Kaohsiung Med Univ, Kaohsiung Univ Med Hosp, Dept Lab Med, Kaohsiung, Taiwan; Kaohsiung Med Univ, Kaohsiung Univ Med Hosp, Translat Res Ctr Neuromuscular Dis, Kaohsiung, Taiwan; Kaohsiung Med Univ, Coll Med, Grad Inst Clin Med, Kaohsiung, Taiwan; Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan ; Chan, Sophelia/AAZ-5026-2021; Chien, Yin-Hsiu/I-2348-2019; Chen, Tai-Heng/G-9900-2012; Chae, Jong/J-5683-2012 27171508400; 16241023700; 7201918882; 7201681358; 24553982400; 55978748900; 36461383000; 57223677748 sophehs@hku.hk;yjjong@gap.kmu.edu.tw; JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY J NEUROL NEUROSUR PS 0022-3050 1468-330X 92 11 SCIE CLINICAL NEUROLOGY;PSYCHIATRY;SURGERY 2021 13.654 1.2 5.64 2025-07-30 17 17 spinal muscular atrophy spinal muscular atrophy Adolescent; Asia; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Oligonucleotides; Retrospective Studies; Spinal Muscular Atrophies of Childhood; Young Adult; nusinersen; survival motor neuron protein 1; survival motor neuron protein 2; nusinersen; oligonucleotide; adolescent; adult; child; clinical article; cohort analysis; controlled study; disease duration; drug efficacy; drug safety; female; Hong Kong; human; infant; Letter; male; newborn screening; observational study; prediction; retrospective study; sitting; SMN1 gene; SMN2 gene; South Korea; standing; survival; Taiwan; treatment duration; treatment outcome; Werdnig Hoffmann disease; Asia; hereditary spinal muscular atrophy; newborn; preschool child; young adult English 2021 2021-11 10.1136/jnnp-2020-324532 바로가기 바로가기 바로가기 바로가기
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