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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | The relationship between tumor-infiltrating lymphocytes, PD-L1 expression, and clinical outcomes of Asian melanoma patients treated with anti-PD-1 antibody. | Lee, Soo Jung; Chae, Yee Soo; Kim, Jong Gwang; Kang, Byung Woog; Baek, Jin Ho; Choi, Hyeokjin; Lee, In Hee; Jeong, Ji Yun | Kyungpook Natl Univ, Chilgok Hosp, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Med Ctr, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Hematol & Oncol, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Daegu, South Korea | Kim, Sung-Bae/JXL-8219-2024 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 38 | 15 | SCIE | ONCOLOGY | 2020 | 44.544 | 1.5 | 0 | English | 2020 | 2020-05-20 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | A phase 3 study comparing switching from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) with continued TDF treatment in virologically-suppressed patients with chronic hepatitis B (CHB): final week 96 efficacy and safety results | Lampertico, Pietro; Buti, Maria; Ramji, Alnoor; Fung, Scott; Ahn, Sang Hoon; Chuang, Wan-Long; Yoon, Seung Kew; Kao, Jia-Horng; Chen, Chi-Yi; Tam, Edward; Khalili, Mandana; Bae, Ho; Ma, Xiaoli; Tak, Won Young; Flaherty, John F.; Gaggar, Anuj; Suri, Vithika; Tan, Susanna; Liu, Yang; Wu, George; Subramanian, Mani; Hann, Hie-Won; Agarwal, Kosh; Lim, Young-Suk; Chan, Henry | Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Milan, Italy; Hosp Gen Univ Valle Hebron & Ciberehd, Barcelona, Spain; Univ British Columbia, Div Gastroenterol, Vancouver, BC, Canada; Toronto Gen Hosp, Univ Hlth Network, Toronto Ctr Liver Dis, Toronto, ON, Canada; Yonsei Univ, Inst Gastroenterol, Dept Internal Med, Coll Med, Seoul, South Korea; Kaohsiung Med Univ Hosp, Hepatobiliary Div, Dept Internal Med, Kaohsiung, Taiwan; Catholic Univ Korea, Dept Internal Med, Seoul, South Korea; Natl Taiwan Univ Hosp, Div Gastroenterol & Hepatol, Taipei, Taiwan; Chia Yi Christian Hosp, Chiayi, Taiwan; LAIR Ctr, Vancouver, BC, Canada; Univ Calif San Francisco, San Francisco, CA 94143 USA; St Vincents Med Ctr, Los Angeles, CA USA; Drexel Univ, Coll Med, Philadelphia, PA USA; Kyungpook Natl Univ, Coll Med, Daegu, South Korea; Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA; Thomas Jefferson Univ Hosp, Div Gastroenterol & Hepatol, Philadelphia, PA USA; Kings Coll Hosp London, Inst Liver Studies, London, England; Univ Ulsan, Ctr Liver, Asan Med Ctr, Dept Gastroenterol,Coll Med, Ulsan, South Korea; Chinese Univ Hong Kong, Dept Med & Therapeut, Inst Digest Dis, Hong Kong, Peoples R China; Chinese Univ Hong Kong, Dept Med & Therapeut, State Key Lab Digest Dis, Hong Kong, Peoples R China | Buti, MARIA/A-5327-2019; KAO, JIA-HORNG/AAB-8947-2019; Agarwal, Kosh/ABH-8721-2020; Kao, JH/AAB-8947-2019; SANG-HOON, AHN/AAV-2600-2020; Lim, Young-Suk/AFQ-5165-2022; Chuang, Wan-Long/C-9536-2009; Chan, Henry/B-9636-2008 | pietro.lampertico@unimi.it; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 4 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis | Background & Aims: Cholestasis comprises a spectrum of liver diseases characterized by the accumulation of bile acids. Bile acids and activation of the farnesoid X receptor (FXR) can inhibit autophagy, a cellular self-digestion process necessary for cellular homeostasis and regeneration. In mice, autophagy appears to be impaired in cholestasis and induction of autophagy may reduce liver injury. Methods: Herein, we explored autophagy in human cholestasis in vivo and investigated the underlying molecular mechanisms in vitro. FXR chromatin immunoprecipitation-sequencing and qPCR were performed in combination with luciferase promoter studies to identify functional FXR binding targets in a human cholestatic liver sample. Results: Autophagic processing appeared to be impaired in patients with cholestasis and in individuals treated with the FXR ligand obeticholic acid (OCA). In vitro, chenodeoxycholic acid and OCA inhibited autophagy at the level of autophagosome to lysosome fusion in an FXR-dependent manner. Rubicon, which inhibits autophago-lysosomal maturation, was identified as a direct FXR target that is induced in cholestasis and by FXR-agonistic bile acids. Genetic inhibition of Rubicon reversed the bile acid-induced impairment of autophagic flux. In contrast to OCA, ursodeoxycholic acid (UDCA), which is a non-FXR-agonistic bile acid, induced autophagolysosome formation independently of FXR, enhanced autophagic flux and was associated with reduced Rubicon levels. Conclusion: In models of human cholestasis, autophagic processing is impaired in an FXR-dependent manner, partly resulting from the induction of Rubicon. UDCA is a potent inducer of hepatic autophagy. Manipulating autophagy and Rubicon may represent a novel treatment concept for cholestatic liver diseases. Lay summary: Autophagy, a cellular self-cleansing process, is impaired in various forms of human cholestasis. Bile acids, which accumulate in cholestatic liver disease, induce Rubicon, a protein that inhibits proper execution of autophagy. Ursodeoxycholic acid, which is the first-line treatment option for many cholestatic liver diseases, induces hepatic autophagy along with reducing Rubicon. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. | Panzitt, Katrin; Jungwirth, Emilian; Krones, Elisabeth; Lee, Jae Man; Pollheimer, Marion; Thallinger, Gerhard G.; Kolb-Lenz, Dagmar; Xiao, Rui; Thorell, Anders; Trauner, Michael; Fickert, Peter; Marschall, Hanns-Ulrich; Moore, David D.; Wagner, Martin | Med Univ Graz, Div Gastroenterol & Hepatol, Graz, Austria; Med Univ Graz, Res Unit Translat Nucl Receptor Res, Graz, Austria; BioTechMed Graz, Omics Ctr Graz, Graz, Austria; Kyungpook Natl Univ, BK21 Plus KNU Biomed Convergence Program, Dept Biochem & Cell Biol, Cell & Matrix Res Inst,Dept Biomed Sci,Sch Med, Daegu, South Korea; Med Univ Graz, Inst Pathol, Graz, Austria; Univ Technol, Inst Computat Biotechnol, Graz, Austria; Med Univ Graz, Ctr Med Res, Graz, Austria; Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Div Cell Biol Histol & Embryol, Graz, Austria; Baylor Coll Med, Mol & Human Genet, Houston, TX 77030 USA; Ersta Hosp, Danderyd Hosp, Dept Clin Sci, Karolinska Inst, Stockholm, Sweden; Ersta Hosp, Dept Surg, Stockholm, Sweden; Med Univ Vienna, Dept Med 3, Div Gastroenterol & Hepatol, Vienna, Austria; Univ Gothenburg, Dept Mol & Clin Med, Gothenburg, Sweden; Sahlgrens Univ Hosp, Gothenburg, Sweden; Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA | Moore, David/JQI-9927-2023; Trauner, Michael/HCH-4032-2022; Marschall, Hanns-Ulrich/K-8842-2017; Lee, Jae/KFF-5361-2024; Thallinger, Gerhard/KQV-0539-2024 | 15766417400; 57209109197; 54953342200; 47461355200; 15923803000; 6507849206; 56720413100; 59783815300; 7003630811; 7006061605; 6701363176; 7006455698; 7404567331; 7404049295 | martin.wagner@medunigraz.at; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 72 | 6 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 1.85 | 2025-06-25 | 56 | 63 | Bile acids; Obeticholic acid; Ursodeoxycholic acid; Nuclear receptors; Vesicle trafficking | FARNESOID X RECEPTOR; URSODEOXYCHOLIC ACID; BILE-ACID; INJURY; METABOLISM; MECHANISMS; EXPRESSION; INSIGHT; ATG14L | Bile acids; Nuclear receptors; Obeticholic acid; Ursodeoxycholic acid; Vesicle trafficking | Autophagosomes; Autophagy; Autophagy-Related Proteins; Chenodeoxycholic Acid; Cholestasis; Cytotoxins; Gene Knockdown Techniques; Hep G2 Cells; Humans; Liver; Lysosomes; Receptors, Cytoplasmic and Nuclear; Retrospective Studies; Signal Transduction; Transfection; Ursodeoxycholic Acid; bile acid; cell marker; chenodeoxycholic acid; chloroquine; farnesoid X receptor; obeticholic acid; regulator protein; Rubicon; tauroursodeoxycholic acid; unclassified drug; ursodeoxycholic acid; autophagy related protein; cell receptor; chenodeoxycholic acid; cytotoxin; farnesoid X-activated receptor; obeticholic acid; RUBCN protein, human; Article; autolysosome; autophagosome; autophagy (cellular); cholestasis; chromatin immunoprecipitation sequencing; concentration response; controlled study; human; human cell; human tissue; immunohistochemistry; in vitro study; in vivo study; lysosome; mouse; nonhuman; priority journal; real time polymerase chain reaction; Western blotting; autophagy; cholestasis; drug effect; gene knockdown; genetic transfection; genetics; Hep-G2 cell line; liver; metabolism; pathology; retrospective study; signal transduction | English | 2020 | 2020-06 | 10.1016/j.jhep.2020.01.014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Guideline change for antiviral therapy reduced the risk of HBV-related HCC development among cirrhotic patients in South Korea | Kim, David; Lee, Jae Seung; Chun, Ho Soo; Lee, Hye Won; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Han, Kwang-Hyub; Lee, Yu Rim; Tak, Won Young; Kweon, Young Oh; Ahn, Sang Hoon; Kim, Seung Up | Yonsei Univ Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Dept Internal Med, Daegu, South Korea | Kim, Jin-Seok/AAK-5424-2020; SANG-HOON, AHN/AAV-2600-2020; Kim, Hyongbum/D-5804-2019; Park, Jun/H-7127-2019; LEE, JAE SEUNG/KHT-9575-2024 | powerof1004@gmail.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Hepatitis B virus (HBV) surface antigen (HBsAg) inhibition with isis 505358 in chronic hepatitis B (CHB) patients on stable nucleos (t)ide analogue (NA) regimen and in NA -naive CHB patients: phase 2a, randomized, double-blind, placebo-controlled study | Yuen, Man-Fung; Heo, Jeong; Jang, Jeong Won; Yoon, Jung-Hwan; Kweon, Young Oh; Park, Sung-Jae; Bennett, C. Frank; Kwoh, T. Jesse | Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China; Pusan Natl Univ Hosp, Med Res Inst, Busan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Busan, South Korea; Ionis Pharmaceut Inc, Carlsbad, CA USA | Jang, Jeong/LOS-2890-2024; Yuen, Richard Man Fung/C-4466-2009; Yoon, Jung/J-5563-2012; Heo, Jeong/MHQ-1390-2025 | jkwoh@ionisph.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 12 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Identification of PD-L1-expressing exosome-derived microRNAs in human hepatocellular carcinoma | Lee, Yu Rim; Seo, Jae Kyoung; Kim, Gyeonghwa; Jang, Se Young; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Park, Jung Gil; Kang, Min Kyu; Lee, Hye Won; Hur, Keun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea | Park, Jung/AAK-5167-2020; Kim, Gyeonghwa/AAQ-6424-2021; Hur, Keun/G-9513-2011; Se Young, Jang/MTD-4362-2025; Kang, Min/U-8050-2018 | deblue00@naver.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Incidence and risk factors for cardiovascular events in patients with advanced fibrosis due to non-alcoholic steatohepatitis: data from the phase 3 STELLAR trials | Noureddin, Mazen; Schattenberg, Joern M.; Crespo, Javier; Kurosaki, Masayuki; Chen, Chi-Yi; Leroy, Vincent; Abdelmalek, Manal; Tak, Won Young; George, Jacob; Shankar, Arun; Ding, Dora; Camargo, Marianne; Kersey, Kathryn; Myers, Robert; Harrison, Stephen; Gomez, Manuel Romero; Sarin, Shiv Kumar; Younossi, Zobair M.; Rinella, Mary; Corey, Kathleen | Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA; Univ Med Ctr Mainz, Dept Med 1, Metab Liver Res Program, Mainz, Germany; Marques de Valdecilla Univ Hosp, Gastroenterol & Hepatol Unit, Santander, Spain; Japanese Red Cross Musashino Hosp, Dept Gastroenterol & Hepatol, Musashino, Tokyo, Japan; Chia Yi Christian Hosp, Chiayi, Taiwan; Ctr Hosp Univ, Grenoble, France; Duke Univ, Durham, NC 27706 USA; Kyungpook Natl Univ, Daegu, South Korea; Westmead Hosp, Sydney, NSW, Australia; Univ Sydney, Sydney, NSW, Australia; Norfolk & Norwich Univ Hosp NHS Fdn Trust, Norwich, Norfolk, England; Gilead Sci Inc, 353 Lakeside Dr, Foster City, CA 94404 USA; Univ Oxford, Radcliffe Dept Med, Oxford, England; Hosp Univ Virgen del Rocio, Seville, Spain; Inst Liver & Biliary Sci, New Delhi, India; Inova Fairfax Med Campus, Falls Church, VA USA; Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA; Massachusetts Gen Hosp, Boston, MA 02114 USA | George, Jacob/KDN-5645-2024; Romero-Gomez, Manuel/L-8030-2014; Abdelmalek, Manal/AAW-2203-2020; Schattenberg, Jörn/C-1301-2013; rinella, mary/AAJ-4065-2021; Aguirre-Crespo, Francisco/F-8698-2018; Harrison, Stephen/GON-3283-2022; Shanker, Arun/C-4779-2009; Younossi, Zobair M./JRY-9916-2023 | marianne.camargo2@gilead.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Long interspersed nuclear element-1 (line-1) hypomethylation is associated with poor outcomes via the activation of ST18 in human hepatocellular carcinoma | Lee, Yu Rim; Kim, Gyeonghwa; Lee, Hye Won; Jang, Se Young; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Park, Jung Gil; Kang, Min Kyu; Hur, Keun | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Dept Internal Med, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Cell & Matrix Res Inst, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Pathol, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea | Park, Jung/AAK-5167-2020; Hur, Keun/G-9513-2011; Se Young, Jang/MTD-4362-2025; Kang, Min/U-8050-2018; Kim, Gyeonghwa/AAQ-6424-2021 | deblue00@naver.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Review | New approaches towards the discovery and evaluation of bioactive peptides from natural resources | Bioactive peptides (BPs) play key roles in regulating cellular metabolism, and are therefore of special interest to the nutraceutical and pharmaceutical industries. Protein digestion is a major route to production of BPs. Biocatalyst-aided processes are advantageous in that they generate protein hydrolysates with high specificity that are non-immunogenic and resistant to proteolysis in the gastrointestinal tract. On the other hand, these approaches are limited by their high production cost and poor diversity of peptides, as well as the requirement for sophisticated analysis for functional validation and scale-up. The recent development of microbial genome and protein databases, together with in silico analysis, have enabled BP design with bioavailability and the identification of new routes for the isolation of BPs from natural resources. In this review, we focus on recent developments in native BP targeting informatics, novel microbial protease mining, and screening methods, which together will accelerate the development of genome-based microbial routes to therapeutic BPs that promote human health and nutrition. | Kang, Nam Joo; Jin, Hyeon-Su; Lee, Sung-Eun; Kim, Hyun Jung; Koh, Hong; Lee, Dong-Woo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu, South Korea; Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA; Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea | ; Kim, Hyun/V-7593-2017; Lee, Jeong-Hoon/Q-1055-2018; Kim, Hyun Jung/V-7593-2017 | 8315288500; 56997924500; 55890041600; 57037642400; 35789948700; 57195068659 | leehicam@yonsei.ac.kr; | CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY | CRIT REV ENV SCI TEC | 1064-3389 | 1547-6537 | 50 | 1 | SCIE | ENVIRONMENTAL SCIENCES | 2020 | 12.561 | 1.6 | 1.66 | 2025-06-25 | 35 | 41 | Bioactive peptides; hydrolysis; informatics; protease; therapeutics | I-CONVERTING-ENZYME; ACE INHIBITORY PEPTIDES; SKELETAL-MUSCLE MYOSIN; PHAGE DISPLAY; POSTTRANSLATIONAL MODIFICATIONS; ANTIOXIDATIVE PEPTIDES; FUNCTIONAL-PROPERTIES; HYDROLYSATE FORMULAS; ORAL INGESTION; BY-PRODUCTS | Bioactive peptides; hydrolysis; informatics; protease; therapeutics | Genes; Hydrolysis; Informatics; Natural resources; Proteolysis; proteinase; synthetic peptide; Bioactive peptides; Cellular metabolism; Functional validation; Gastrointestinal tract; Pharmaceutical industry; protease; Protein hydrolysate; therapeutics; bioactivity; bioavailability; digestion; drug; genome; hydrolysis; informatics; peptide; production cost; Article; biocatalyst; biological activity; drug determination; drug screening; drug targeting; enzymatic hydrolysis; fermentation; health promotion; human; in vitro study; microbial genome; natural resource; nonhuman; phage display; Peptides | English | 2020 | 2020-01-02 | 10.1080/10643389.2019.1619376 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | The association with low skeletal muscle mass and carotid atherosclerosis in patients with non-alcoholic fatty liver disease | Kang, Min Kyu; Park, Jung Gil; Park, Soo Young; Tak, Won Young; Kweon, Young Oh; Jang, Se Young; Lee, Yu Rim; Hur, Keun | Yeungnam Univ, Coll Med, Internal Med, Gyongsan, South Korea; Kyungpook Natl Univ, Sch Med, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med Biochem & Cell Biol, Daegu, South Korea | Se Young, Jang/MTD-4362-2025; Hur, Keun/G-9513-2011; Kang, Min/U-8050-2018; Park, Jung/AAK-5167-2020 | kmggood111@naver.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Ultrasonic degradation of selected dyes using Ti3C2Tx MXene as a sonocatalyst | MXene, a new family of two dimensional materials, was utilized as a sonocatalyst in an ultrasonic treatment (US) process for removal of methylene blue (MB) and acid blue 80 (AB). The physico-chemical properties of MXene were characterized using scanning electron microscopy, transmission electron microscopy, porosimetry, and a zeta potential analyzer. Degradation of dyes by US was systemically investigated under several experimental conditions including: power density of US (45, 90, 135, and 180 W L-1), frequency of US (28 and 970 kHz), pH of dye solution (3.5, 7, and 10.5), solution temperature (293, 303, and 313 K), and addition of hydroxyl radical promotor (H2O2) and scavenger (t-BuOH) to concentrations of 25 mM. Based on the experimental results, the quantity of H2O2, which was used as an indicator of hydroxyl radical concentration, was an important factor in determining the degradation rate of MB and AB in this US study. Additionally, synergetic indices for removal of both dyes were higher than 1.0 in all cases, indicating the outstanding efficiency of MXene as a sonocatalyst in the US reactor for removal of both, due to an increase in both (i) the quantity of H2O2 in the US reactor and (ii) active sites for adsorbates from dispersion effects. A stability WA on MXene in the US process was conducted using X-ray diffraction and five-cycle recycling performance tests. Based on our experimental data, MXene can be utilized as a sonocatalyst in the US process for a high removal rate for dyes (e.g., MB). | Jun, Byung-Moon; Han, Jonghun; Park, Chang Min; Yoon, Yeomin | Univ South Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA; Korea Army Acad Youngcheon, Dept Civil & Environm Engn, 495 Hogook Ro, Youngcheon 38900, Gyeongbuk, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea | ; Yoon, Yeomin/KDP-2253-2024; Park, Chang Min/CAA-8506-2022; Jun, Byung-Moon/Y-2134-2019 | 55326699900; 59803784200; 57209588953; 7402126688 | yoony@cec.sc.edu; | ULTRASONICS SONOCHEMISTRY | ULTRASON SONOCHEM | 1350-4177 | 1873-2828 | 64 | SCIE | ACOUSTICS;CHEMISTRY, MULTIDISCIPLINARY | 2020 | 7.491 | 1.6 | 2.98 | 2025-06-25 | 55 | 56 | Wastewater treatment; MXene; Methylene blue; Acid blue 80; Sonocatalytic degradation | ENDOCRINE-DISRUPTING COMPOUNDS; TITANIUM CARBIDE; AQUEOUS-SOLUTION; GLASS-BEADS; REMOVAL; ADSORPTION; CARBON; SULFAMETHOXAZOLE; ACETAMINOPHEN; CARBAMAZEPINE | Acid blue 80; Methylene blue; MXene; Sonocatalytic degradation; Wastewater treatment | Aromatic compounds; Degradation; Dyes; High resolution transmission electron microscopy; Scanning electron microscopy; Wastewater treatment; adsorbent; hydrogen peroxide; hydroxyl radical; methylene blue; tert butyl hydroperoxide; titanium derivative; Experimental conditions; Methylene Blue; MXene; Sonocatalytic degradation; Two-dimensional materials; Ultrasonic degradation; Ultrasonic treatments; Zeta potential analyzers; adsorption; Article; catalyst; concentration (parameter); controlled study; decolorization; degradation; dispersion; pH; physical chemistry; priority journal; scanning electron microscopy; temperature; transmission electron microscopy; ultrasound; waste water recycling; X ray diffraction; zeta potential; Stripping (dyes) | English | 2020 | 2020-06 | 10.1016/j.ultsonch.2020.104993 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Validation of diagnostic usefulness of the spot urine Na/K ratio for replacement of 24-hour urine NA excretion in cirrhotic patients with ascites | Lee, Jinwook; Hwang, Jae-Seok; Chung, Woo Jin; Lee, Heonju; Park, Jung Gil; Lee, Changhyeong; Kim, Byung Seok; Song, Jung Eun; Kweon, Young Oh; Tak, Won Young; Park, Soo Young; Jang, Se Young; Suh, Jeong Ill; Jang, Byoung Kuk | Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Catholic Univ, Dept Internal Med, Daegu Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Internal Med, Coll Med, Daegu, South Korea; Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea | Se Young, Jang/MTD-4362-2025; Park, Jung/AAK-5167-2020; Kim, Seul Kee/A-6076-2015; Kim, Jin Hyoung/AAE-8050-2019 | jangha106@dsmc.or.kr; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 73 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 25.083 | 1.6 | 0 | English | 2020 | 2020-08 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | A novel herbal formulation consisting of red ginseng extract and Epimedium koreanum Nakai-attenuated dextran sulfate sodium-induced colitis in mice | Background: Ulcerative colitis (UC) is a commonly encountered large intestine disease in the contemporary world that terminates into colorectal cancer; therefore, the timely treatment of UC is of major concern. Panax ginseng Meyer is an extensively consumed herbal commodity in South East Asian countries, especially Korea. It exhibits a wide range of biologically beneficial qualities for almost head-to-toe ailments in the body. Epimedium koreanum Nakai (EKN) is also a widely used traditional Korean herbal medicine used for treating infertility, rheumatism, and cardiovascular diseases. Materials and methods: Separately the anti-inflammatory activities of both red ginseng extracts (RGEs) and EKNs had been demonstrated in the past in various inflammatory models; however, we sought to unravel the anti-inflammatory activities of the combination of these two extracts in dextran sulfate sodium (DSS)-induced ulcerative colitis in mice model because the allopathic remedies for UC involve more side effects than benefits. Results: Our results have shown that the combination of RGE + EKN synergistically alleviated the macroscopic lesions in DSS-induced colitic mice such as colon shortening, hematochezia, and weight loss. Moreover, it restored the histopathological lesions in mice and decreased the levels of proinflammatory mediators and cytokines through the repression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP-3) expression. In vitro, this combination also reduced the magnitude of nitric acid (NO), proinflammatory mediators and cytokine through NF-kappa B and mitogen-activated protein kinase (MAPK) pathways in RAW 264.7 mouse macrophage cells. Conclusion: In the light of these findings, we can endorse this combination extract as a functional food for the prophylactic as well as therapeutic treatment of UC in humans together with allopathic remedies. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Saba, Evelyn; Lee, Yuan Yee; Kim, Minki; Hyun, Sun-Hee; Park, Chae-Kyu; Son, Eunjung; Kim, Dong-Seon; Kim, Sung-Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol, 80 Daehak Ro, Daegu 41566, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon, South Korea; Korea Inst Oriental Med, KM Convergence Res Div, Daejeon, South Korea; Dongnam Inst Radiol & Med Sci, Res Ctr, 40 Jwadong Gil, Busan 46033, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Vet Biomed Sci, Rawalpindi, Pakistan | Saba, Evelyn/JLN-1878-2023; Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016 | 56721112000; 57203798815; 57199747297; 57225302366; 55885553100; 57195251310; 56947571300; 55156746000; 57211035357 | sdkim@dirams.re.kr;rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 6 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 1.17 | 2025-06-25 | 20 | 20 | Epimedium koreanum Nakai; NF-kappa B; Nucleotide-binding domain (NOD)-like re-ceptor protein 3; Red ginseng extract; Ulcerative colitis | NF-KAPPA-B; NLRP3 INFLAMMASOME; PANAX-GINSENG; ULCERATIVE-COLITIS; DSS; ACTIVATION; MEYER | Epimedium koreanum Nakai; NF-κB; Nucleotide-binding domain (NOD)-like receptor protein 3; Red ginseng extract; Ulcerative colitis | antiinflammatory agent; cryopyrin; Epimedium koreanum nakai extract; ginseng extract; immunoglobulin enhancer binding protein; mitogen activated protein kinase; nitric acid; plant extract; salazosulfapyridine; unclassified drug; allopathy; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; body weight loss; controlled study; dextran sulfate sodium-induced ulcerative colitis; drug potentiation; Epimedium koreanum; ginseng; herbal medicine; histopathology; in vitro study; in vivo study; male; mouse; nonhuman; priority journal; protein blood level; protein expression; RAW 264.7 cell line; rectum hemorrhage | English | 2020 | 2020-11 | 10.1016/j.jgr.2020.02.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Adaptogenic effects of Panax ginseng on modulation of cardiovascular functions | Cardiovascular diseases are a rapidly growing epidemic with high morbidity and mortality. There is an urgent need to develop nutraceutical-based therapy with minimum side effects to reduce cardiovascular risk. Panax ginseng occupies a prominent status in herbal medicine for its various therapeutic effects against inflammation, allergy, diabetes, cardiovascular diseases, and even cancer, with positive, beneficial, and restorative effects. The active components found in most P. ginseng varieties are known to include ginsenosides, polysaccharides, peptides, alkaloids, polyacetylene, and phenolic compounds, which are considered to be the main pharmacologically active constituents in ginseng. P. ginseng is an adaptogen. That is, it supports living organisms to maintain optimal homeostasis by exerting effects that counteract physiological changes caused by physical, chemical, or biological stressors. P. ginseng possesses immunomodulatory (including both immunostimulatory and immunosuppressive), neuromodulatory, and cardioprotective effects; suppresses anxiety; and balances vascular tone. P. ginseng has an antihypertensive effect that has been explained by its vasorelaxant action, and paradoxically, it is also known to increase blood pressure by vasoconstriction and help maintain cardiovascular health. Here, we discuss the potential adaptogenic effects of P. ginseng on the cardiovascular system and outline a future research perspective in this area. (C) 2020 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Irfan, Muhammad; Kwak, Yi-Seong; Han, Chang-Kyun; Hyun, Sun Hee; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Physiol & Cell Signaling, Daegu 41566, South Korea; Korean Ginseng Cooperat, R&D Headquarters, Daejeon 34520, South Korea | Irfan, Muhammad/AAY-1961-2021; Rhee, Man/O-5705-2016 | 35069404400; 36868130200; 57190975167; 57225302366; 57211035357 | shhyun@kgc.co.kr;rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 44 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2020 | 6.06 | 1.8 | 1.98 | 2025-06-25 | 57 | 61 | Adaptogen; Cardioprotective; Ginsenoside; Panax ginseng; Vascular endothelium | KOREAN RED GINSENG; INHIBITS PLATELET ACTIVATION; NITRIC-OXIDE; GINSENOSIDES; ENDOTHELIUM; EXTRACT; DISEASE; ANTIPLATELET; RG1; HYPERCHOLESTEROLEMIA | Adaptogen; Cardioprotective; Ginsenoside; Panax ginseng; Vascular endothelium | aphrodisiac agent; ginseng extract; adaptation; adaptogenic effect; Alzheimer disease; antihypertensive activity; antiobesity activity; antiplatelet activity; blood vessel tone; blood viscosity; cardiovascular disease; cardiovascular function; diastolic blood pressure; drug effect; drug mechanism; ginseng; heart protection; human; hypertension; hypolipidemic activity; physical activity; physical performance; priority journal; Review; sexual health; structure activity relation; systolic blood pressure; therapy effect; vasoconstriction; vasodilatation; vasomotor system | English | 2020 | 2020-07 | 10.1016/j.jgr.2020.03.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | ADENOSINE AND GUANOSINE-BASED OLIGONUCLEOTIDE ATTENUATES IL-1β-MEDIATED CATABOLIC PHENOTYPES OF CHONDROCYTES AND SURGICALLY INDUCED OSTEOARTHRITIS PROGRESSION IN MICE | Park, D.; Shin, D.; Jung, Y. -K.; Kim, J.; Han, S. | Daegu Fatima Hosp, Daegu, South Korea; Gyeongsang Natl Univ Hosp, Jinju, South Korea; Chungnam Natl Univ Hosp, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea | OSTEOARTHRITIS AND CARTILAGE | OSTEOARTHR CARTILAGE | 1063-4584 | 1522-9653 | 28 | SCIE | ORTHOPEDICS;RHEUMATOLOGY | 2020 | 6.576 | 1.8 | 0 | English | 2020 | 2020-04 | 바로가기 | 바로가기 |
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