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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Nurse-Administered Propofol Continuous Infusion Sedation for Gastrointestinal Endoscopy in Patients Who Are Difficult to Sedate ⓘ BACKGROUND & AIMS: Patients who chronically use alcohol, marijuana, or opioids, or suffer from post-traumatic stress disorder (PTSD), can be difficult to sedate with midazolam and fentanyl, and often are referred for monitored anesthesia care during endoscopy. Nurse-administered propofol continuous infusion sedation (NAPCIS), which confers the benefit of propofol-based sedation without the added expense of anesthesia, is effective and safe for sedation of healthy patients. We investigated whether NAPCIS also is effective for patients who are difficult to sedate. METHODS: We performed a retrospective study of patients who underwent upper endoscopy or colonoscopy with NAPCIS at a single center from January 2018 through April 2018. We reviewed records from patients who were heavy users of alcohol (n = 105), daily users of marijuana (n = 267) or opioids (n = 178), had a diagnosis of PTSD (n = 91), or were none of these (controls, n = 786). We compared mean fentanyl and propofol doses (adjusted for body weight), procedure and recovery times, procedure success rates, and adverse events. RESULTS: Compared with the controls, the marijuana group required higher mean adjusted sedative doses for colonoscopies (0.6 vs 0.4 mcg/kg fentanyl and 5.0 vs 4.7 mg/kg propofol; P <= .025 for both) and upper endoscopies (0.8 vs 0.3 mcg/kg fentanyl and 3.7 vs 3.2 mg/kg propofol; P <= .021 for both), the PTSD group required a higher dose of fentanyl for colonoscopies (0.6 vs 0.4 mcg/kg; P = .009), and the alcohol group required a higher dose of fentanyl for upper endoscopies (0.7 vs 0.3 mcg/kg; P < .001). Procedure success rates were high (95.1%-100%) and did not differ significantly between the difficult-to-sedate groups and controls; mean procedure times (7.0-9.0 minutes for upper endoscopies, 21.1-22.9 minutes for colonoscopies) and recovery times (22.5-29.6 minutes) also were similar among groups. Upper endoscopies were associated with lower sedative doses and shorter procedure and recovery times than colonoscopies. Sedation-related adverse events were rare in all groups (only 26 cases total), and there were no serious complications or deaths. CONCLUSIONS: NAPCIS seems to be a safe and effective means of providing sedation for endoscopy to patients who may be difficult to sedate owing to alcohol, marijuana, or opioid use, or PTSD. ⓘ Lee, Hyun Seok; Nagra, Navroop; La Selva, Danielle; Kozarek, Richard A.; Ross, Andrew; Weigel, Wade; Beecher, Ryan; Chiorean, Michael; Gluck, Michael; Boden, Elisa; Venu, Nanda; Krishnamoorthi, Rajesh; Larsen, Michael; Lin, Otto S. ⓘ Virginia Mason Med Ctr, Digest Dis Inst, 1100 Ninth Ave, Seattle, WA 98101 USA; Virginia Mason Med Ctr, Dept Anesthesia, Seattle, WA 98101 USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea ⓘ Chiorean, Michael/AAZ-5305-2021; Kim, Hyung-Ho/HZM-2707-2023; krishnamoorthi, rajesh/AAG-4265-2020; Boden, Elisa/IVV-0165-2023; Kozarek, Richard/AAF-2695-2020 ⓘ 36647886100; 57211291945; 56580303000; 7102200958; 8626748600; 8352428500; 57193670055; 18133792800; 7102445679; 6604035766; 6504121200; 24314692800; 26434418800; 7006650197 ⓘ Otto.Lin@vmmc.org; ⓘ CLINICAL GASTROENTEROLOGY AND HEPATOLOGY ⓘ CLIN GASTROENTEROL H ⓘ 1542-3565 1542-7714 19 1 SCIE GASTROENTEROLOGY & HEPATOLOGY ⓘ 2021 13.576 7.0 1 2025-07-30 ⓘ 18 18 Risk Factor; Outcome; Efficacy; Safety ⓘ UNITED-STATES; EXPERIENCE; EFFICIENCY; GUIDELINE; EFFICACY; SAFETY; COST ⓘ Efficacy; Outcome; Risk Factor; Safety ⓘ Anesthesia; Conscious Sedation; Endoscopy, Gastrointestinal; Fentanyl; Humans; Hypnotics and Sedatives; Propofol; Retrospective Studies; fentanyl; propofol; fentanyl; hypnotic sedative agent; propofol; adult; alcoholism; anesthesia complication; anesthetic recovery; Article; body weight; cannabis addiction; colonoscopy; conscious sedation; continuous infusion; controlled study; difficult to sedate; dose response; drug dose comparison; drug efficacy; drug safety; female; gastrointestinal endoscopy; human; major clinical study; male; nurse; nurse administered propofol continuous infusion sedation; opiate addiction; posttraumatic stress disorder; retrospective study; anesthesia; conscious sedation; gastrointestinal endoscopy ⓘ English 2021 2021-01 10.1016/j.cgh.2020.09.018 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Terahertz Line-of-Sight MIMO Communication: Theory and Practical Challenges ⓘ A relentless trend in wireless communications is the hunger for bandwidth, and fresh bandwidth is only to be found at ever higher frequencies. While 5G systems are seizing the mmWave band, the attention of researchers is shifting already to the terahertz range. In that distant land of tiny wavelengths, antenna arrays can serve for more than power-enhancing beamforming. Defying lower-frequency wisdom, spatial multiplexing becomes feasible even in line-of-sight conditions. This article reviews the underpinnings of this phenomenon, and it surveys recent results on the ensuing information-theoretic capacity. Reconfigurable array architectures are put forth that can closely approach such capacity, practical challenges are discussed, and supporting experimental evidence is presented. ⓘ Do, Heedong; Cho, Sungmin; Park, Jeonghun; Song, Ho-Jin; Lee, Namyoon; Lozano, Angel ⓘ POSTECH, Potsdam, Germany; Kyungpook Natl Univ, Daegu, South Korea; Univ Pompeu Fabra, Barcelona, Spain ⓘ Do, Heedong/ACJ-2701-2022; Lozano, Angel/A-3332-2012; Lee, Namyoon/ADH-9232-2022; Aldhahir, Naofal/HCH-5192-2022 ⓘ 57208405854; 57215036992; 57853652900; 55568215200; 35148128800; 24781002200 ⓘ ⓘ IEEE COMMUNICATIONS MAGAZINE ⓘ IEEE COMMUN MAG ⓘ 0163-6804 1558-1896 59 3 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS ⓘ 2021 9.03 7.0 4.52 2025-07-30 ⓘ 66 80 ⓘ CAPACITY; CHANNELS ⓘ ⓘ 5G mobile communication systems; Beamforming; Reconfigurable architectures; Seizing; High frequency HF; Line of Sight; Lines-of-sight; MIMO communication; Mm-wave band; Power; Tera Hertz; Terahertz range; Wavelength antennas; Wireless communications; Bandwidth ⓘ English 2021 2021-03 10.1109/mcom.001.2000714 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Timing Alignment in Molecular-Communication-Based Nanonetworks ⓘ With the growth in the diversity of novel molecular communication via diffusion-based (MCvD) applications, the term synchronization can entail different technologies in MCvD-based nanonetworks - from relatively simple collaborative actions to complex symbol timing recovery. Motivated by the need for distinction or uniformity in the technologies, we introduce the notion of timing alignment, which is an umbrella term that includes any element that enables nanomachines to execute processes or actions in an organized manner. Four elements of timing alignment are identified, namely, hardware, protocol, network, and application. In a tutorial manner, the elements are described both at the microscopic level (as individual elements) and at the macroscopic level (as collective elements). A combination of existing and new knowledge is used to elicit the challenges that lie in the path of the development of MCvD-based medical systems. Timing alignment can therefore be approached either as a single topic or by its elements. ⓘ Shitiri, Ethungshan; Cho, Ho-Shin ⓘ Kyungpook Natl Univ, Daegu, South Korea; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea ⓘ Shitiri, Ph.D., Ethungshan/Z-5918-2019 ⓘ 57190818428; 35316924900 ⓘ ethungshan@ee.knu.ac.kr;hscho@ee.knu.ac.kr; ⓘ IEEE COMMUNICATIONS MAGAZINE ⓘ IEEE COMMUN MAG ⓘ 0163-6804 1558-1896 59 5 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS ⓘ 2021 9.03 7.0 0.2 2025-07-30 ⓘ 3 3 ⓘ ⓘ ⓘ Nanotechnology; Timing circuits; Complex symbols; Macroscopic levels; Medical systems; Microscopic levels; Molecular communication; Nano-networks; Nanomachines; Timing alignment; Alignment ⓘ English 2021 2021-05 10.1109/mcom.001.2000959 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ A Method for Integrating Delayed Recharge Flux Through Unsaturated Zones into Analytical and Numerical Groundwater Flow Modeling ⓘ The temporal delay in the water table's response to precipitation is a common phenomenon. Using a mathematical model, we developed a function that represents the recharge flux through unsaturated zones of varying thickness to model the delayed response of groundwater level due to precipitation. The recharge flux from the developed function was integrated into the analytical and numerical models to estimate the actual groundwater levels in the unsaturated zone. The analytical and numerical models accurately determined the actual groundwater levels. Additionally, calibrated hydraulic parameters from numerical estimates reflected the values measured in the actual aquifer, thereby highlighting the potential application of the developed function to wide-ranging groundwater problems. Based on the recharge function, a recharge module can be developed for existing flow simulators to enhance groundwater modeling. ⓘ Park, Eungyu; Jeong, Jina; Choung, Sungwook; Han, Weon Shik; Kim, Kue-Young; Suk, Heejun ⓘ Kyungpook Natl Univ, Dept Geol, Daegu, South Korea; Korea Basic Sci Inst, Res Ctr Geochronol & Isotope Anal, Cheongju, South Korea; Yonsei Univ, Dept Earth Syst Sci, Seoul, South Korea; Korea Inst Geosci & Mineral Resources, Daejeon, South Korea ⓘ ; suk, heejun/A-3212-2015; Han, Weon Shik/KCY-0126-2024 ⓘ 23995577700; 55488558800; 36436826400; 57226420125; 15029920800; 23996203400 ⓘ egpark@knu.ac.kr; ⓘ WATER RESOURCES RESEARCH ⓘ WATER RESOUR RES ⓘ 0043-1397 1944-7973 57 3 SCIE ENVIRONMENTAL SCIENCES;LIMNOLOGY;WATER RESOURCES ⓘ 2021 6.159 7.1 0.95 2025-07-30 ⓘ 11 12 analytical modeling; delayed groundwater level response; delayed recharge flux; numerical modeling; unsaturated zones ⓘ ⓘ analytical modeling; delayed groundwater level response; delayed recharge flux; numerical modeling; unsaturated zones ⓘ Analytical models; Aquifers; Estimation; Functions; Groundwater flow; Groundwater resources; Numerical methods; Recharging (underground waters); Analytical and numerical models; Delayed response; Groundwater Flow Model; Groundwater modeling; Hydraulic parameters; Recharge flux; Unsaturated zone; Varying thickness; analytical method; aquifer; flow modeling; flux measurement; groundwater; groundwater flow; hydrological modeling; methodology; numerical method; precipitation (climatology); recharge; simulator; vadose zone; water level; water table; Numerical models ⓘ English 2021 2021-03 10.1029/2020wr027655 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An organometal halide perovskite photocathode integrated with a MoS2 catalyst for efficient and stable photoelectrochemical water splitting ⓘ Photoelectrochemical water splitting using organometal halide perovskites (OHPs) is an attractive and sustainable method for converting solar energy to hydrogen (H-2). However, the poor stability of OHPs in aqueous electrolytes and the use of Pt, a noble metal, as a hydrogen evolution reaction (HER) catalyst restrict the practical application of OHP-based photocathodes. Herein, we report an efficient and stable OHP-based photocathode using Ti foil as the protective encapsulation layer and earth-abundant and cost-effective MoS2 as the HER catalyst. The fabricated MoS2/Ti foil/OHP photocathode presents a remarkable half-cell solar-to-hydrogen conversion efficiency of 11.07%, a photocurrent density of -20.6 mA cm(-2) at 0 V versus the reversible hydrogen electrode (vs. RHE), and an onset potential of 1.02 V vs. RHE. Furthermore, the MoS2/Ti foil/OHP photocathode exhibits a record long-term PEC stability in aqueous electrolytes over 120 h of illumination. Our study provides insights into designing the structure of OHP-based photocathodes for efficient and stable solar H-2 production. ⓘ Choi, Hojoong; Seo, Sehun; Kim, Ju-Hyeon; Lee, Jong-Hoon; Kim, Seungkyu; Piao, Guangxia; Park, Hyunwoong; Lee, Kwanghee; Lee, Sanghan ⓘ Gwangju Inst Sci & Technol, Sch Mat Sci & Engn, Gwangju 61005, South Korea; Gwangju Inst Sci & Technol, Heeger Ctr Adv Mat, Gwangju 61005, South Korea; Huree Univ Informat & Commun Technol, Dept Energy Resources, Ulaanbaatar 160610036, Mongolia; Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Gwangju Inst Sci & Technol, Res Inst Solar & Sustainable Energies, Gwangju 61005, South Korea ⓘ Lee, Sanghan/AAH-1105-2019; Park, Hyunwoong/A-1247-2012 ⓘ 57212019941; 57192688623; 58925648400; 57203144580; 57201488172; 57193277010; 7601565583; 55737466200; 55716521500 ⓘ klee@gist.ac.kr;sanghan@gist.ac.kr; ⓘ JOURNAL OF MATERIALS CHEMISTRY A ⓘ J MATER CHEM A ⓘ 2050-7488 2050-7496 9 39 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2021 14.511 7.1 0.86 2025-07-30 ⓘ 23 21 ⓘ HYDROGEN EVOLUTION; HIGHLY EFFICIENT; SOLAR; PROGRESS; DEFECTS; FILMS; SI ⓘ ⓘ Catalysts; Cost effectiveness; Electrolytes; Field emission cathodes; Layered semiconductors; Metal halides; Molybdenum compounds; Perovskite; Photoelectrochemical cells; Precious metals; Solar energy; Solar power generation; Aqueous electrolyte; Cost effective; Encapsulation layer; Halide perovskites; Hydrogen evolution reactions; Photoelectrochemical water splitting; Poor stability; Protective encapsulation; Ti foil; ]+ catalyst; Photocathodes ⓘ English 2021 2021-10-12 10.1039/d1ta05377a ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Disease-specific ACMG/AMP guidelines improve sequence variant interpretation for hearing loss ⓘ Purpose: The ClinGen Variant Curation Expert Panels (VCEPs) provide disease-specific rules for accurate variant interpretation. Using the hearing loss-specific American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) guidelines, the Hearing Loss VCEP (HL VCEP) illustrates the utility of expert specifications in variant interpretation. Methods: A total of 157 variants across nine HL genes, previously submitted to ClinVar, were curated by the HL VCEP. The curation process involved collecting published and unpublished data for each variant by biocurators, followed by bimonthly meetings of an expert curation subgroup that reviewed all evidence and applied the HL-specific ACMG/AMP guidelines to reach a final classification. Results: Before expert curation, 75% (117/157) of variants had single or multiple variants of uncertain significance (VUS) submissions (17/157) or had conflicting interpretations in ClinVar (100/157). After applying the HL-specific ACMG/AMP guidelines, 24% (4/17) of VUS and 69% (69/100) of discordant variants were resolved into benign (B), likely benign (LB), likely pathogenic (LP), or pathogenic (P). Overall, 70% (109/157) variants had unambiguous classifications (B, LB, LP, P). We quantify the contribution of the HL-specified ACMG/AMP codes to variant classification. Conclusion: Expert specification and application of the HL-specific ACMG/AMP guidelines effectively resolved discordant interpretations in ClinVar. This study highlights the utility of ClinGen VCEPs in supporting more consistent clinical variant interpretation. © 2021, The Author(s), under exclusive licence to the American College of Medical Genetics and Genomics. ⓘ Patel, Mayher J.; DiStefano, Marina T.; Oza, Andrea M.; Hughes, Madeline Y.; Wilcox, Emma H.; Hemphill, Sarah E.; Cushman, Brandon J.; Grant, Andrew R.; Siegert, Rebecca K.; Shen, Jun; Chapin, Alex; Boczek, Nicole J.; Schimmenti, Lisa A.; Nara, Kiyomitsu; Kenna, Margaret; Azaiez, Hela; Booth, Kevin T.; Avraham, Karen B.; Kremer, Hannie; Griffith, Andrew J.; Rehm, Heidi L.; Amr, Sami S.; Tayoun, Ahmad N. Abou; Abdelhak, Sonia; Alexander, John; Brownstein, Zippora; Burt, Rachel; Choi, Byung Yoon; Downie, Lilian; Friedman, Thomas; Giersch, Anne; Greinwald, John; Holt, Jeffrey; Hosoya, Makoto; Kim, Un-Kyung; Krantz, Ian; Leal, Suzanne; Masmoudi, Saber; Matsunaga, Tatsuo; Morín, Matías; Morton, Cynthia; Mutai, Hideki; Pandya, Arti; Smith, Richard; Tekin, Mustafa; Usami, Shin-Ichi; Van Camp, Guy; Yamazawa, Kazuki; Yuan, Hui-Jun; Black-Zeigelbein, Elizabeth; Zhang, Kejian ⓘ The Broad Institute of MIT and Harvard, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States, Precision Health Program, Geisinger, Danville, PA, United States; Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States, Department of Otolaryngology and Communication Enhancement, Boston Children’s Hospital, Boston, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States; Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States; Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States, Harvard Medical School, Boston, MA, United States; ARUP Laboratories, Salt Lake City, UT, United States; Department of Laboratory Medicine & Pathology, Mayo Clinic, Rochester, MN, United States; Department of Otorhinolaryngology, Clinical Genomics and Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, United States; Division of Hearing and Balance Research, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan; Department of Otolaryngology and Communication Enhancement, Boston Children’s Hospital, Boston, MA, United States, Harvard Medical School, Boston, MA, United States; Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology, University of Iowa Hospital and Clinics, Iowa City, IA, United States; Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology, University of Iowa Hospital and Clinics, Iowa City, IA, United States, Department of Neurobiology, Harvard Medical School, Boston, MA, United States; Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Department of Human Genetics, Radboud University Medical Center, Nijmegen, Netherlands; Department of Otolaryngology Head-Neck Surgery, College of Medicine, The University of Tennessee Health Science Center, Memphis, TN, United States; The Broad Institute of MIT and Harvard, Cambridge, MA, United States, Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States; Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, MA, United States, Harvard Medical School, Boston, MA, United States; Al Genomics Center, Al Jalila Children’s Specialty Hospital, Dubai, United Arab Emirates, Center for Genomic Discovery, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates; Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, Tunis, Tunisia; EGL Genetics/Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, United States, ConsulGene, LLC, Jacksonville, FL, United States, Department of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, United States; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel; Molecular Hearing Laboratory, Murdoch Children’s Research Institute, Parkville, Australia; Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea; Murdoch Children’s Research Institute, Melbourne, Australia; Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD, United States; Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Department of Otolaryngology–Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, United States; Indiana University School of Medicine, Indianapolis, IN, United States; National Hospital Organization Tokyo Medical Center, National Institute of Sensory Organs, Tokyo, Japan; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, United States; Laboratory of Statistical Genetics, Rockefeller University, New York, NY, United States; Laboratoire Procédés de Criblage Moléculaire et Cellulaire, Centre de Biotechnologie de Sfax, Université de Sfax, Sfax, Tunisia; Division of Hearing and Balance Research, National Hospital Organization Tokyo Medical Center, Tokyo, Japan, Medical Genetics Center, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan; Servicio de Genética, Ramón y Cajal Institute of Health Research (IRYCIS) and Biomedical Network Research Centre on Rare Diseases (CIBERER), Madrid, Spain; Departments of Obstetrics and Gynecology and of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States, Manchester Centre for Audiology and Deafness, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom, The Broad Institute, Cambridge, MA, United States; National Hospital Organization Tokyo Medical Center, National Institute of Sensory Organs, Tokyo, Japan; Division of Pediatric Genetics and Metabolism, Department of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Internal Medicine and Otolaryngology, University of Iowa Carver College of Medicine, Iowa City, IA, United States; John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, United States; Department of Otolaryngology, Shinshu University School of Medicine, Matsumoto, Japan, Department of Hearing Implant Sciences, Shinshu University School of Medicine, Matsumoto, Japan; Department of Medical Genetics, University of Antwerp, Antwerp, Belgium; Medical Genetics Center, National Hospital Organization Tokyo Medical Center, Tokyo, Meguro, Japan; Southwest Hospital in China, Chongqing Shi, China; Molecular Otolaryngology and Renal Research Laboratories, Department of Otolaryngology-Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States, Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, United States ⓘ ⓘ 57219994186; 57194266441; 57189730526; 57207947411; 57219990598; 57202929716; 57202925093; 57204010820; 57204126799; 56276570200; 57204148153; 36573211200; 6701347868; 57194897346; 7004944503; 6505967691; 56196413600; 7007074258; 36014154200; 7006238207; 57195311049; 56389409700; 35298507700; 6603711657; 59437557200; 6506970826; 7202453687; 57529370900; 57221756528; 34569115500; 56711853600; 7004315663; 7402070150; 53979723900; 7102248968; 7004409233; 57663931800; 7003473163; 7401741650; 24169592700; 7201605341; 6603240487; 55799495900; 16073972500; 7005614191; 35431954200; 34573802800; 13103124900; 10139104100; 57207950616; 55445465000 ⓘ Ahmad.Tayoun@ajch.ae; ⓘ Genetics in Medicine ⓘ GENET MED ⓘ 1098-3600 1530-0366 23 11 SCIE GENETICS & HEREDITY ⓘ 2021 8.864 7.1 2.45 2025-07-30 ⓘ 34 ⓘ ⓘ ⓘ Adenosine Monophosphate; Genetic Testing; Genetic Variation; Genome, Human; Hearing Loss; Humans; adenosine phosphate; Article; disease classification; evidence based medicine; gene; gene mutation; gene sequence; genetic code; genetic variability; hearing impairment; human; information processing; medical expert; practice guideline; uncertainty; genetic screening; genetic variation; genetics; hearing impairment; human genome ⓘ English Final 2021 10.1038/s41436-021-01254-2 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Electric field-driven one-step formation of vertical p-n junction TiO2 nanotubes exhibiting strong photocatalytic hydrogen production ⓘ In this study, vertically aligned p-n junction TiO2 nanotubes can be formed by anodization of the Ti substrate following the addition of a high electric field in a Pd precursor-containing electrolyte. The bottom region of the TiO2 nanotubes with a high concentration of Pd because of the high electric field which was induced to be p-type. In contrast, the region with a low Pd concentration (top of the TiO2 nanotubes) was determined to be n-type, similar to the pristine TiO2. The concentration profile of the dopant in TiO2 nanotubes was investigated via TOF-SIMS and XPS. Defect formation energies in TiO2 nanotubes were estimated using density-functional theory calculation to understand the p-n junction formation. The p-n junction TiO2 nanotubes showed a high photocatalytic hydrogen production rate of 25.2 mu L cm(-2) h(-1) under solar light irradiation as a result of the enhancement of visible light photoactivity. ⓘ Kim, Moonsu; Lee, Jaewon; Je, Minyeong; Heo, Bumgi; Yoo, Hyeonseok; Choi, Heechae; Choi, Jinsub; Lee, Kiyoung ⓘ Inha Univ, Dept Chem & Chem Engn, 100 Inha Ro, Incheon 22212, South Korea; Kyungpook Natl Univ, Dept Adv Sci & Technol Convergence, 2559 Gyeongsangdae Ro, Sangju 37224, Gyeongsangbuk D, South Korea; Univ Cologne, Inst Inorgan Chem, Theoret Mat & Chem Grp, 6 Greinstr, Cologne, Germany; POSCO, Steel Solut Res Lab, 100 Songdogwahak Ro, Incheon 21985, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsangdae Ro, Sangju 37224, Gyeongsangbuk D, South Korea ⓘ Choi, Heechae/AFM-0327-2022; Choi, Jinsub/D-7131-2012; Lee, Kiyoung/J-8680-2013; Choi, Heechae/U-5776-2018; Kim, Moonsu/LTY-5404-2024 ⓘ 55653198600; 59830462300; 56800306900; 57221753126; 56470196200; 24469888700; 55722493700; 57219211501 ⓘ h.choi@uni-koeln.de;jinsub@inha.ac.kr;kiyoung@knu.ac.kr; ⓘ JOURNAL OF MATERIALS CHEMISTRY A ⓘ J MATER CHEM A ⓘ 2050-7488 2050-7496 9 4 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2021 14.511 7.1 0.76 2025-07-30 ⓘ 16 17 ⓘ INTRINSIC AU-DECORATION; THIN-FILMS; HETEROJUNCTION; ANODIZATION; PERFORMANCE; FABRICATION; STABILITY; EVOLUTION; CATALYST; OXIDE ⓘ ⓘ Density functional theory; Electric fields; Electrolytes; Light; Oxide minerals; Photocatalytic activity; Semiconductor junctions; Titanium dioxide; Concentration profiles; Defect formation energies; High electric fields; P-n junction formation; Photocatalytic hydrogen production; Solar light irradiation; Step formation; Vertically aligned; Hydrogen production ⓘ English 2021 2021-01-28 10.1039/d0ta10062e ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Organic cathode interfacial materials for non-fullerene organic solar cells ⓘ Amine-containing polyelectrolytes such as polyethyleneimine (PEI) are commonly used as cathode interfacial materials (CIMs); however, they are rarely found in non-fullerene acceptor (NFA) organic solar cells due to undesirable chemical reactions between PEI and NFAs. Unveiling the nature of these chemical interactions and developing chemically stable amine-containing polyelectrolytes is inevitable for achieving highly efficient and stable NFA organic solar cells. Herein, the reaction between PEI and 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (INCN)-based NFAs was investigated using a model system. N-15-isotope labeling experiments and 2D nuclear magnetic resonance (NMR) studies revealed that the products were generated by the Michael addition reaction and existed as the keto-enol tautomers. Based on the identified undesirable reaction, we developed a series of functionalized PEIs that are compatible with INCN-based NFAs by protecting the reactive amine functional groups. Highly efficient and stable NFA organic solar cells were successfully fabricated by the use of functionalized PEIs with broad work function tunability and improved chemical stability, which led to NFA organic solar cells with high power conversion efficiency (PCE) values of over 15% and thermally stable device operation for more than 360 hours at 100 degrees C. ⓘ Kyeong, Minkyu; Lee, Jinho; Daboczi, Matyas; Stewart, Katherine; Yao, Huifeng; Cha, Hyojung; Luke, Joel; Lee, Kwanghee; Durrant, James R.; Kim, Ji-Seon; Hong, Sukwon ⓘ Gwangju Inst Sci & Technol, Dept Chem, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea; Incheon Natl Univ, Dept Phys, 119 Acad Ro, Incheon 22012, South Korea; Imperial Coll London, Ctr Processable Elect, Dept Chem, White City Campus,Wood Lane, London W12 0BZ, England; Imperial Coll London, Ctr Processable Elect, Dept Phys, Exhibit Rd, London SW7 2AZ, England; Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China; Gwangju Inst Sci & Technol, Res Inst Solar & Sustainable Energies, 123 Cheomdan Gwagiro, Gwangju 61005, South Korea; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea ⓘ ; Kim, Seong-Gon/AAF-7553-2020; Daboczi, Matyas/HNC-5680-2023; Hong, Sukwon/B-9543-2011; Luke, Joel/P-6425-2018; Durrant, James/A-6198-2009; Leem, Jung Woo/D-5363-2011; Kim, Ji-Seon/Y-3301-2018; Yao, Huifeng/V-7890-2019 ⓘ ⓘ ji-seon.kim@imperial.ac.uk;shong@gist.ac.kr; ⓘ JOURNAL OF MATERIALS CHEMISTRY A ⓘ J MATER CHEM A ⓘ 2050-7488 2050-7496 9 23 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2021 14.511 7.1 ⓘ 34 ⓘ HIGHLY EFFICIENT; WORK FUNCTION; PHOTOVOLTAIC CELLS; ACCEPTOR; LAYER; POLYELECTROLYTES ⓘ ⓘ ⓘ English 2021 2021-06-21 10.1039/d1ta01609a ⓘ 바로가기 바로가기 바로가기
○ Review ⓘ Recent advances in non-precious group metal-based catalysts for water electrolysis and beyond ⓘ As the demand for green hydrogen (H-2) rapidly increases, the development of water electrolysis technology has been receiving great attention. Indeed, recent remarkable advances in catalyst materials increased the feasibility of water electrolysis for a future H-2 economy and technology. In this review, we summarize representative non-precious group metal-based materials for achieving active and stable water electrolysis performances. Our comprehensive range of the state-of-the-art catalysts includes doped carbon catalysts, metal borides, metal carbides, metal oxides, metal phosphides, metal sulfides, and single-atom catalysts. For each class of materials, we focus on the synthesis and catalytic performances of the state-of-the-art materials toward water electrolysis and present the current challenges and outlooks of such materials, along with prospective insights to develop and realize practical systems. ⓘ Kim, Hee Jin; Kim, Ho Young; Joo, Jinwhan; Joo, Sang Hoon; Lim, June Sung; Lee, Jinwoo; Huang, Huawei; Shao, Minhua; Hu, Jue; Kim, Jin Young; Min, Byeong Jo; Lee, Seung Woo; Kang, Minsoo; Lee, Kwangyeol; Choi, Songa; Park, Yeji; Wang, Yao; Li, Junjun; Zhang, Zhicheng; Ma, Jianmin; Choi, Sang-Il ⓘ Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; Korea Inst Sci & Technol KIST, Ctr Hydrogen & Fuel Cell Res, Seoul 02792, South Korea; Korea Univ, Dept Chem, Seoul 02841, South Korea; Korea Univ, Res Inst Nat Sci, Seoul 02841, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Dept Chem, Ulsan 44919, South Korea; Ulsan Natl Inst Sci & Technol UNIST, Sch Energy & Chem Engn, Ulsan 44919, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Chem & Biomol Engn, Daejeon 34141, South Korea; Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China; Kunming Univ Sci & Technol, Fac Met & Energy Engn, Kunming 650093, Yunnan, Peoples R China; Korea Univ Sci & Technol UST, KIST Sch, Div Energy Environment Engn, Daejeon, South Korea; Georgia Inst Technol, Woodruff Sch Mech Engn, Atlanta, GA 30332 USA; Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China; Tianjin Univ, Sch Sci, Dept Chem, Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China; Univ Elect Sci & Technol China, Sch Mat & Energy, Chengdu 610054, Peoples R China; Kyungpook Natl Univ, Dept Hydrogen & Renewable Energy, Daegu 41566, South Korea ⓘ ; Hu, Jue/AEX-3873-2022; Ma, Jianmin/M-5217-2013; Kim, Hee Jin/I-3252-2017; Lee, Kwangyeol/A-9269-2010; LI, JUNJUN/I-4492-2012; Lee, Seung/B-5820-2013; Zhang, Zhicheng/AAQ-2833-2020; huang, huawei/KYP-0529-2024; Kim, Joo Hyun/C-6604-2019; shao, minhua/LSL-2089-2024; Choi, Sang-Il/AGR-1133-2022; Kim, Ho Young/GRR-2801-2022; Joo, Sang Hoon/E-5898-2010 ⓘ ⓘ shjoo@unist.ac.kr;jwlee1@kaist.ac.kr;kemshao@ust.hk;hujue@kust.edu.cn;jinykim@kist.re.kr;seung.lee@me.gatech.edu;kylee1@korea.ac.kr;zczhang19@tju.edu.cn;sichoi@knu.ac.kr; ⓘ JOURNAL OF MATERIALS CHEMISTRY A ⓘ J MATER CHEM A ⓘ 2050-7488 2050-7496 10 1 SCIE CHEMISTRY, PHYSICAL;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2021 14.511 7.1 ⓘ 74 ⓘ OXYGEN EVOLUTION REACTION; EFFICIENT HYDROGEN EVOLUTION; HIGH-PERFORMANCE ELECTROCATALYSTS; SINGLE-ATOM CATALYSTS; ACTIVE EDGE SITES; N-DOPED CARBON; HIGHLY EFFICIENT; BIFUNCTIONAL ELECTROCATALYST; TRANSITION-METAL; NICKEL SULFIDE ⓘ ⓘ ⓘ English 2021 2021-12-21 10.1039/d1ta06548c ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus ⓘ Objective Systemic lupus erythematosus (SLE), an autoimmune disorder, has been associated with nearly 100 susceptibility loci. Nevertheless, these loci only partially explain SLE heritability and their putative causal variants are rarely prioritised, which make challenging to elucidate disease biology. To detect new SLE loci and causal variants, we performed the largest genome-wide meta-analysis for SLE in East Asian populations. Methods We newly genotyped 10 029 SLE cases and 180 167 controls and subsequently meta-analysed them jointly with 3348 SLE cases and 14 826 controls from published studies in East Asians. We further applied a Bayesian statistical approach to localise the putative causal variants for SLE associations. Results We identified 113 genetic regions including 46 novel loci at genome-wide significance (p= 0.1 for 57 SLE loci, among which we prioritised 10 most likely putative causal variants (posterior probability >= 0.8). Linkage disequilibrium score regression detected genetic correlations for SLE with albumin/globulin ratio (r(g)=-0.242) and non-albumin protein (r(g)=0.238). Conclusion This study reiterates the power of large-scale genome-wide meta-analysis for novel genetic discovery. These findings shed light on genetic and biological understandings of SLE. ⓘ Yin, Xianyong; Kim, Kwangwoo; Suetsugu, Hiroyuki; Bang, So-Young; Wen, Leilei; Koido, Masaru; Ha, Eunji; Liu, Lu; Sakamoto, Yuma; Jo, Sungsin; Leng, Rui-Xue; Otomo, Nao; Laurynenka, Viktoryia; Kwon, Young-Chang; Sheng, Yujun; Sugano, Nobuhiko; Hwang, Mi Yeong; Li, Weiran; Mukai, Masaya; Yoon, Kyungheon; Cai, Minglong; Ishigaki, Kazuyoshi; Chung, Won Tae; Huang, He; Takahashi, Daisuke; Lee, Shin-Seok; Wang, Mengwei; Karino, Kohei; Shim, Seung-Cheol; Zheng, Xiaodong; Miyamura, Tomoya; Kang, Young Mo; Ye, Dongqing; Nakamura, Junichi; Suh, Chang-Hee; Tang, Yuanjia; Motomura, Goro; Park, Yong-Beom; Ding, Huihua; Kuroda, Takeshi; Choe, Jung-Yoon; Li, Chengxu; Niiro, Hiroaki; Park, Youngho; Shen, Changbing; Miyamoto, Takeshi; Ahn, Ga-Young; Fei, Wenmin; Takeuchi, Tsutomu; Shin, Jung-Min; Li, Keke; Kawaguchi, Yasushi; Lee, Yeon-Kyung; Wang, Yongfei; Amano, Koichi; Park, Dae Jin; Yang, Wanling; Tada, Yoshifumi; Yamaji, Ken; Shimizu, Masato; Atsumi, Takashi; Suzuki, Akari; Sumida, Takayuki; Okada, Yukinori; Matsuda, Koichi; Matsuo, Keitaro; Kochi, Yuta; Kottyan, Leah C.; Weirauch, Matthew T.; Parameswaran, Sreeja; Eswar, Shruti; Salim, Hanan; Chen, Xiaoting; Yamamoto, Kazuhiko; Harley, John B.; Ohmura, Koichiro; Kim, Tae-Hwan; Yang, Sen; Yamamoto, Takuaki; Kim, Bong-Jo; Shen, Nan; Ikegawa, Shiro; Lee, Hye-Soon; Zhang, Xuejun; Terao, Chikashi; Cui, Yong; Bae, Sang-Cheol ⓘ Anhui Med Univ, Affiliated Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China; Anhui Med Univ, Inst Dermatol, Hefei, Anhui, Peoples R China; Anhui Med Univ, Key Lab Dermatol, Minist Educ, Hefei, Anhui, Peoples R China; Inflammat & Immune Mediated Dis Lab Anhui Prov, Hefei, Anhui, Peoples R China; China Japan Friendship Hosp, Dept Dermatol, Beijing, Peoples R China; Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA; Kyung Hee Univ, Dept Biol, Seoul, South Korea; Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea; RIKEN Ctr Med Sci, Lab Bone & Joint Dis, Yokohama, Kanagawa, Japan; RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet Anal, Yokohama, Kanagawa, Japan; Kyushu Univ, Grad Sch Med Sci, Dept Orthopaed Surg, Fukuoka, Japan; Hanyang Univ, Dept Rheumatol, Hosp Rheumat Dis, Seoul, South Korea; Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Univ Tokyo, Inst Med Sci, Dept Canc Biol, Div Mol Pathol, Tokyo, Japan; Koga Hosp 21, Fukuoka, Japan; Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China; Keio Univ, Dept Orthoped Surg, Sch Med, Tokyo, Japan; Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol CAGE, Cincinnati, OH 45229 USA; Osaka Univ, Dept Orthopaed Med Engn, Grad Sch Med, Osaka, Japan; Osong Hlth Technol Adm Complex, Natl Inst Hlth, Ctr Genome Sci, Div Genome Res, Cheongju, South Korea; Sapporo City Gen Hosp, Dept Rheumatol & Clin Immunol, Sapporo, Hokkaido, Japan; Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Genet, Boston, MA 02115 USA; Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Div Rheumatol, Boston, MA 02115 USA; Harvard Med Sch, Ctr Data Sci, Boston, MA 02115 USA; Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA; Dong A Univ Hosp, Dept Internal Med, Busan, South Korea; Hokkaido Univ, Fac Med, Dept Orthopaed Surg, Sapporo, Hokkaido, Japan; Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan; Chonnam Natl Univ Med Sch & Hosp, Dept Internal Med, Div Rheumatol, Gwangju, South Korea; Hokkaido Univ, Dept Rheumatol Endocrinol & Nephrol, Fac Med, Sapporo, Hokkaido, Japan; Chungnam Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Daejeon, South Korea; Natl Hosp Org, Kyushu Med Ctr, Dept Internal Med & Rheumatol, Fukuoka, Japan; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Daegu, South Korea; Chiba Univ, Grad Sch Med, Dept Orthopaed Surg, Chiba, Japan; Ajou Univ, Dept Rheumatol, Sch Med, Suwon, South Korea; Shanghai Jiao Tong Univ, Shanghai Inst Rheumatol, Sch Med SJTUSM, Renji Hosp, Shanghai, Peoples R China; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Niigata Univ, Hlth Adm Ctr, Niigata, Japan; Catholic Univ Daegu, Dept Rheumatol, Sch Med, Daegu, South Korea; Kyushu Univ, Dept Med Educ, Grad Sch Med Sci, Fukuoka, Japan; Peking Univ, Dept Dermatol, Shenzhen Hosp, Shenzhen, Guangdong, Peoples R China; Hong Kong Univ Sci & Technol, Shenzhen Key Lab Translat Med Dermatol, Shenzhen Peking Univ, Med Ctr, Shenzhen, Guangdong, Peoples R China; Kumamoto Univ, Dept Orthopaed Surg, Fac Life Sci, Kumamoto, Japan; Keio Univ, Dept Internal Med, Div Rheumatol, Sch Med, Tokyo, Japan; Tokyo Womens Med Univ, Inst Rheumatol, Tokyo, Japan; Univ Hong Kong, Dept Paediat & Adolescent Med, Pok Fu Lam, Hong Kong, Peoples R China; Saitama Med Univ, Saitama Med Ctr, Dept Rheumatol & Clin Immunol, Saitama, Japan; Saga Univ, Dept Rheumatol, Fac Med, Saga, Japan; Juntendo Univ, Dept Internal Med & Rheumatol, Sch Med, Tokyo, Japan; Hokkaido Med Ctr Rheumat Dis, Sapporo, Hokkaido, Japan; Showa Univ, Dept Orthopaed Surg, Sch Med, Tokyo, Japan; RIKEN Ctr Integrat Med Sci, Lab Autoimmune Dis, Yokohama, Kanagawa, Japan; Univ Tsukuba, Dept Internal Med, Fac Med, Ibaraki, Japan; Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan; Osaka Univ, Immunol Frontier Res Ctr WPi iFReC, Lab Stat Immunol, Osaka, Japan; Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Genome Technol, Tokyo, Japan; Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Clin Genome Sequencing, Tokyo, Japan; Aichi Canc Ctr Res Inst, Div Canc Epidemiol & Prevent, Nagoya, Aichi, Japan; Nagoya Univ, Dept Epidemiol, Grad Sch Med, Nagoya, Aichi, Japan; Tokyo Med & Dent Univ, Med Res Inst, Dept Genom Funct & Divers, Tokyo, Japan; Univ Cincinnati, Dept Pediat, Cincinnati, OH USA; US Dept Vet Affairs, Med Ctr, Cincinnati, OH USA; Kyoto Univ, Dept Rheumatol & Clin immunol, Grad Sch Med, Kyoto, Japan; Fukuoka Univ, Dept Orthopaed Surg, Fac Med, Fukuoka, Japan; Shanghai Jiao Tong Univ, Sch Med SJTUSM, State Key Lab Oncogenes & Related Genes, Shanghai Canc Inst,Renji Hosp, Shanghai, Peoples R China; Fudan Univ, Inst Dermatol, Huashan Hosp, Dept Dermatol, Shanghai, Peoples R China; Shizuoka Prefectural Gen Hosp, Clin Res Ctr, Shizuoka, Japan; Univ Shizuoka, Sch Pharmaceut Sci, Dept Appl Genet, Shizuoka, Japan ⓘ Jo, Sungsin/AAL-3659-2021; Bae, Sang-Cheol/P-2051-2015; tang, yuan/MVU-4402-2025; Ishigaki, Kazuyoshi/ABF-6926-2021; Kochi, Yuta/P-4487-2018; Li, Yuqing/AAR-9383-2021; Matsuo, Keitaro/H-6758-2019; Suzuki, Akari/N-5389-2015; Ding, Huihua/H-7768-2019; Koido, Masaru/I-2930-2019; Li, Shaofu/O-2241-2019; Liu, Lu/JVN-3656-2024; Sheng, Yujun/ABG-1999-2021; Terao, Chikashi/AAY-1207-2021; Kottyan, Leah/H-3050-2019; Kim, Kwangwoo/T-8098-2018; Suh, Chang-Hee/H-9723-2019; NIIRO, HIROAKI/KMX-5542-2024; Lippert, Christoph/M-2992-2016; Liu, keke/HKF-4509-2023; Lee, Seung Hwan/AAE-4710-2022; 沈, 长兵/KDO-5447-2024; Lee, Shin-Seok/AAC-6779-2021; Ha, Eunji/MTD-3549-2025; Yamamoto, Yuji/LTC-6062-2024; Shen, Nan/AGK-6807-2022; Takahashi, Daisuke/F-7647-2014; Li, Weiran/HZJ-3346-2023; zheng, xiaodong/C-4050-2008; Weirauch, Matthew/M-5459-2019; Kim, Tae-Hwan/M-3962-2017; Takeuchi, Tsutomu/L-2327-2013 ⓘ 15840916700; 35186283600; 56702993000; 25645654000; 55303543700; 55624124900; 57211941553; 57221211334; 55366943200; 54399737400; 35933584400; 57203790310; 57220198397; 57218574113; 57202809302; 7101688414; 55523326400; 56591841400; 55978437300; 57205678421; 57208856424; 36141626500; 57077585300; 57205299605; 36001395800; 16643309600; 57220200289; 57205137745; 7202796196; 56413364400; 7101873367; 26221798000; 24588340700; 35473800400; 56188447500; 8748533800; 6506966152; 7405369878; 57125301700; 7402298010; 7201513769; 57210435659; 6701396754; 57191333167; 55884737200; 57189986671; 57205106320; 57200532390; 55535576900; 57210826527; 57220198633; 58844522700; 57210831495; 57211416305; 7201828534; 57224762646; 23101349500; 7202223291; 7102241682; 7404138635; 7102259736; 35339881300; 57207157392; 7005443464; 35327525800; 7401602814; 55908909600; 35107524200; 35363202800; 57210110114; 57220200852; 57220200123; 56388791400; 55739398600; 7201902945; 7005775040; 57171134400; 9243500800; 8069263600; 56125152900; 7102785475; 57208688968; 16425988900; 34668762500; 35182021300; 36189902700; 56902138700 ⓘ chikashi.terao@riken.jp;wuhucuiyong@vip.163.com;scbae@hanyang.ac.kr; ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 80 5 SCIE RHEUMATOLOGY ⓘ 2021 28.003 7.3 7.19 2025-07-30 ⓘ 113 112 lupus erythematosus; systemic; polymorphism; genetic; epidemiology ⓘ GENOME-WIDE ASSOCIATION; GENOTYPE IMPUTATION; GENETIC ASSOCIATION; CHINESE; VARIANTS; GWAS; INDIVIDUALS; REPLICATION ⓘ epidemiology; genetic; lupus erythematosus; polymorphism; systemic ⓘ Adult; Asian Continental Ancestry Group; Bayes Theorem; Case-Control Studies; China; Far East; Female; Genetic Loci; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Genotype; Humans; Japan; Lupus Erythematosus, Systemic; Male; Middle Aged; Prevalence; Republic of Korea; Article; Bayesian network; case control study; CHD23 gene; cohort analysis; controlled study; East Asian; gene identification; gene linkage disequilibrium; gene locus; gene mapping; genetic heterogeneity; genetic susceptibility; genome-wide association study; genotype; human; logistic regression analysis; LRRK1 gene; priority journal; probability; systemic lupus erythematosus; adult; Asian continental ancestry group; Bayes theorem; China; ethnology; Far East; female; gene locus; genetic predisposition; genetic variation; genetics; Japan; male; meta analysis; middle aged; prevalence; South Korea; systemic lupus erythematosus ⓘ English 2021 2021-05 10.1136/annrheumdis-2020-219209 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ SPLENIC METABOLIC UPTAKE IN FDG-PET/CT PREDICTS RISK OF FUTURE CARDIOVASCULAR THROMBOSIS EVENTS IN PATIENTS WITH RHEUMATOID ARTHRITIS ⓘ ⓘ Lee, S. J.; Hong, C. M.; Kang, Y. M. ⓘ Kyungpook Natl Univ, Sch Med, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Nucl Med, Daegu, South Korea ⓘ Li, Shaofu/O-2241-2019 ⓘ ⓘ ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 80 SCIE RHEUMATOLOGY ⓘ 2021 28.003 7.3 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-06 10.1136/annrheumdis-2021-eular.3574 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ TREATMENT OF ANKYLOSING SPONDYLITIS WITH TUMOR NECROSIS FACTOR-ALPHA INHIBITORS LOWERS THE RISK OF RENAL FUNCTION DECLINE ⓘ ⓘ Lee, S. J.; Lee, J. S.; Cha, U. C.; Nam, E. J. ⓘ Kyungpook Natl Univ, Sch Med, Internal Med, Daegu, South Korea ⓘ ⓘ ⓘ ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 80 SCIE RHEUMATOLOGY ⓘ 2021 28.003 7.3 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2021 2021-06 10.1136/annrheumdis-2021-eular.3605 ⓘ 바로가기 바로가기 바로가기
○ Erratum ⓘ Author Correction: Prediction-based highly sensitive CRISPR off-target validation using target-specific DNA enrichment (Nature Communications, (2020), 11, 1, (3596), 10.1038/s41467-020-17418-8) ⓘ In the original version of this Article, the Acknowledgements incorrectly stated a grant from the National Research Foundation funded by the Korean Ministry of Education, Science and Technology as “NRF-2019M3A9H110378”. It should be stated as “NRF- 2019M3A9H1103783”. This has been corrected in the PDF and HMTL version of the article. © 2021, The Author(s). ⓘ Kang, Seung-Hun; Lee, Wi-jae; An, Ju-Hyun; Lee, Jong-Hee; Kim, Young-Hyun; Kim, Hanseop; Oh, Yeounsun; Park, Young-Ho; Jin, Yeung Bae; Jun, Bong-Hyun; Hur, Junho K.; Kim, Sun-Uk; Lee, Seung Hwan ⓘ Department of Medicine, Graduate School, Kyung Hee University, Seoul, South Korea, Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Bioscience and Biotechnology, Konkuk University, Seoul, 143-701, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea, National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, School of Life Sciences and Biotechnology, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Division of Biotechnology, College of Life Science and Biotechnology, Korea University, Seoul, 02841, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea; Department of Bioscience and Biotechnology, Konkuk University, Seoul, 143-701, South Korea; Department of Pathology, College of Medicine, Kyung Hee University, Seoul, South Korea, Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul, South Korea, Department of Medical Genetics, College of Medicine, Hanyang University, Seoul, South Korea; Futuristic Animal Resource & Research Center (FARRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea, Department of Functional Genomics, KRIBB School of Bioscience, Korea University of Science and Technology (UST), Daejeon, South Korea; National Primate Research Center (NPRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, South Korea ⓘ ⓘ 57218162734; 57218165418; 57210789913; 57203736066; 54393408600; 57203630238; 57218169850; 56246852400; 35344928700; 35229652600; 35740323500; 8278891100; 57202327400 ⓘ sunuk@kribb.re.kr;lsh080390@kribb.re.kr;jh0210@gmail.com; ⓘ Nature Communications ⓘ NAT COMMUN ⓘ N/A 2041-1723 12 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 17.694 7.4 0 2025-07-30 ⓘ 0 ⓘ ⓘ ⓘ erratum ⓘ English Final 2021 10.1038/s41467-020-20559-5 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Bayesian log-normal deconvolution for enhanced in silico microdissection of bulk gene expression data ⓘ Deconvolution of bulk gene expression profiles into the cellular components is pivotal to portraying tissue's complex cellular make-up, such as the tumor microenvironment. However, the inherently variable nature of gene expression requires a comprehensive statistical model and reliable prior knowledge of individual cell types that can be obtained from single-cell RNA sequencing. We introduce BLADE (Bayesian Log-normAl Deconvolution), a unified Bayesian framework to estimate both cellular composition and gene expression profiles for each cell type. Unlike previous comprehensive statistical approaches, BLADE can handle > 20 types of cells due to the efficient variational inference. Throughout an intensive evaluation with > 700 simulated and real datasets, BLADE demonstrated enhanced robustness against gene expression variability and better completeness than conventional methods, in particular, to reconstruct gene expression profiles of each cell type. In summary, BLADE is a powerful tool to unravel heterogeneous cellular activity in complex biological systems from standard bulk gene expression data. Deconvolution methods reveal individual cell types in complex tissues profiled by bulk methods. Here the authors present a Bayesian deconvolution method that outperforms existing methods when benchmarked on >700 datasets, especially in estimating cell-type-specific gene expression profiles. ⓘ Barbosa, Barbara Andrade; van Asten, Saskia D.; Oh, Ji Won; Farina-Sarasqueta, Arantza; Verheij, Joanne; Dijk, Frederike; van Laarhoven, Hanneke W. M.; Ylstra, Bauke; Vallejo, Juan J. Garcia; van de Wiel, Mark A.; Kim, Yongsoo ⓘ Vrije Univ Amsterdam, Amsterdam UMC, Canc Ctr Amsterdam, Dept Pathol, Amsterdam, Netherlands; Vrije Univ Amsterdam, Amsterdam Infect & Immun Inst, Amsterdam UMC, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Univ Amsterdam, Dept Pathol, Amsterdam UMC, Amsterdam, Netherlands; Univ Amsterdam, Canc Ctr Amsterdam, Dept Med Oncol, Amsterdam UMC, Amsterdam, Netherlands; Vrije Univ Amsterdam, Amsterdam Publ Hlth Res Inst, Dept Epidemiol & Data Sci, Amsterdam UMC, Amsterdam, Netherlands ⓘ Garcia-Vallejo, Juan J./H-4162-2012; van de Wiel, Mark/F-6759-2013; Dijk, Frederike/CAG-1492-2022; van Laarhoven, Hanneke/AAW-3464-2021; Ylstra, Bauke/D-2906-2012; Oh, Ji/AAZ-3153-2020; Vallejo, Juan/AAA-3765-2020 ⓘ 57305994100; 57190442992; 36093206200; 36672799700; 7003347663; 57196668113; 9333923600; 6602138118; 6602764355; 6701725064; 57189642969 ⓘ mark.vdwiel@amsterdamumc.nl;yo.kim@amsterdamumc.nl; ⓘ NATURE COMMUNICATIONS ⓘ NAT COMMUN ⓘ 2041-1723 12 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 17.694 7.4 0.73 2025-07-30 ⓘ 16 15 ⓘ ⓘ ⓘ Bayes Theorem; Computer Simulation; Gene Expression Profiling; Humans; Leukocytes, Mononuclear; Machine Learning; Models, Statistical; Neoplasms; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome; Workflow; transcriptome; cell; deconvolution; gene expression; model; RNA; standard (reference); article; biology; computer model; controlled study; deconvolution; gene expression profiling; microdissection; protein expression; simulation; single cell RNA seq; tumor microenvironment; Bayes theorem; computer simulation; cytology; genetics; human; machine learning; metabolism; mononuclear cell; neoplasm; pathology; procedures; sequence analysis; single cell analysis; statistical model; workflow ⓘ English 2021 2021-10-20 10.1038/s41467-021-26328-2 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Clonal hematopoiesis is associated with risk of severe Covid-19 ⓘ Clonal haematopoiesis (CH) has been associated with altered inflammatory profiles and increased risk of cardiovascular and malignant diseases. Here, the authors analyze patient data from two different cohorts and show that CH is associated with severe infections and severe Covid19. Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed in patients with CH. A pro-inflammatory immunologic profile is also associated with worse outcomes of certain infections, including SARS-CoV-2 and its associated disease Covid-19. Whether CH predisposes to severe Covid-19 or other infections is unknown. Among 525 individuals with Covid-19 from Memorial Sloan Kettering (MSK) and the Korean Clonal Hematopoiesis (KoCH) consortia, we show that CH is associated with severe Covid-19 outcomes (OR = 1.85, 95%=1.15-2.99, p = 0.01), in particular CH characterized by non-cancer driver mutations (OR = 2.01, 95% CI = 1.15-3.50, p = 0.01). We further explore the relationship between CH and risk of other infections in 14,211 solid tumor patients at MSK. CH is significantly associated with risk of Clostridium Difficile (HR = 2.01, 95% CI: 1.22-3.30, p = 6x10(-3)) and Streptococcus/Enterococcus infections (HR = 1.56, 95% CI = 1.15-2.13, p = 5x10(-3)). These findings suggest a relationship between CH and risk of severe infections that warrants further investigation. ⓘ Bolton, Kelly L.; Koh, Youngil; Foote, Michael B.; Im, Hogune; Jee, Justin; Sun, Choong Hyun; Safonov, Anton; Ptashkin, Ryan; Moon, Joon Ho; Lee, Ji Yeon; Jung, Jongtak; Kang, Chang Kyung; Song, Kyoung-Ho; Choe, Pyoeng Gyun; Park, Wan Beom; Kim, Hong Bin; Oh, Myoung-don; Song, Han; Kim, Sugyeong; Patel, Minal; Derkach, Andriy; Gedvilaite, Erika; Tkachuk, Kaitlyn A.; Wiley, Brian J.; Chan, Ireaneus C.; Braunstein, Lior Z.; Gao, Teng; Papaemmanuil, Elli; Babady, N. Esther; Pessin, Melissa S.; Kamboj, Mini; Diaz, Luis A., Jr.; Ladanyi, Marc; Rauh, Michael J.; Natarajan, Pradeep; Machiela, Mitchell J.; Awadalla, Philip; Joseph, Vijai; Offit, Kenneth; Norton, Larry; Berger, Michael F.; Levine, Ross L.; Kim, Eu Suk; Kim, Nam Joong; Zehir, Ahmet ⓘ Washington Univ, Dept Med, St Louis, MO 63130 USA; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Genome Opin Inc, Seoul, South Korea; Seoul Natl Univ Hosp, Ctr Precis Med, Seoul, South Korea; Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA; Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Natl Med Ctr, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Mem Sloan Kettering Canc Ctr, Ctr Hematol Malignancies, New York, NY USA; Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA; Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, 1275 York Ave, New York, NY 10021 USA; Mem Sloan Kettering Canc Ctr, Ctr Computat Oncol, Dept Epidemiol & Biostat, Computat Oncol Serv, New York, NY USA; Mem Sloan Kettering Canc Ctr, Dept Lab Med, New York, NY USA; Queens Univ, Dept Pathol & Mol Med, Kingston, ON, Canada; Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA USA; Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA; NCI, Div Canc Epidemiol & Genet, Bethesda, MD USA; Ontario Inst Canc Res, Toronto, ON, Canada; Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Res Lab, New York, NY USA ⓘ Ladanyi, Marc/AAG-8585-2019; levine, ross/AAE-7658-2019; Joseph, Vijai/J-9158-2013; Zehir, Ahmet/ABE-7155-2020; Bin Kim, Hong/J-5452-2012; Diaz, Luis/ABD-5602-2021; Machiela, Mitchell/H-7335-2019; Im, Hogune/ABG-3002-2021; Park, Wan Beom/GLU-9886-2022; Moon, Joonho/KFQ-2464-2024; Natarajan, Pradeep/H-9764-2019; Kim, Eu/J-5424-2012; Kim, Nam-Joong/J-2735-2012; Kim, Junho/JFJ-1013-2023; Gao, Teng/ABA-4913-2022 ⓘ 24740981400; 56450114900; 57215189579; 59430942300; 57218316210; 57188670163; 57221483483; 56175270100; 56568642700; 57196137881; 57205246545; 55808491400; 23398486700; 15070608400; 7402229219; 35307429400; 7201600302; 57221475954; 57221473582; 55464128800; 55368357000; 57191477409; 57214764526; 57301288200; 57301141800; 56497696200; 57219564109; 14632245200; 57211324716; 35430377400; 13606769500; 57203774615; 7006141808; 7004242307; 35422683300; 57205131998; 6602423686; 57215142114; 57214986390; 36979172200; 57210008206; 55187363200; 22938086900; 35495869100; 35209315700 ⓘ bolton@wustl.edu;eskim@snubh.org;molder@unitel.co.kr;zehira@mskcc.org; ⓘ NATURE COMMUNICATIONS ⓘ NAT COMMUN ⓘ 2041-1723 12 1 SCIE MULTIDISCIPLINARY SCIENCES ⓘ 2021 17.694 7.4 4.49 2025-07-30 ⓘ 52 91 ⓘ MUTATIONS ⓘ ⓘ Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Clonal Hematopoiesis; Cohort Studies; COVID-19; Female; Hematopoietic Stem Cells; Humans; Infant; Infant, Newborn; Male; Middle Aged; Mutation; Neoplasms; Risk Factors; SARS-CoV-2; Severity of Illness Index; Clostridium difficile; SARS coronavirus; Streptococcus; COVID-19; detection method; disease; disease severity; health risk; infectious disease; tumor; adult; aged; Article; clonal hematopoiesis; Clostridium difficile infection; controlled study; coronavirus disease 2019; disease association; enterococcal infection; female; genetic susceptibility; human; major clinical study; male; middle aged; newborn; odds ratio; risk assessment; solid malignant neoplasm; Streptococcus infection; very elderly; adolescent; child; cohort analysis; etiology; genetics; hematopoietic stem cell; immunology; infant; mutation; neoplasm; pathology; preschool child; risk factor; severity of illness index; virology ⓘ English 2021 2021-10-13 10.1038/s41467-021-26138-6 ⓘ 바로가기 바로가기 바로가기 바로가기
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