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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Nonlinear Differential Braking Control for Collision Avoidance during Lane Change | In this paper, a nonlinear differential braking control method is developed to avoid collision during lane change under driver torque. The lateral dynamics consist of lateral offset error and yaw error dynamics and can be interpreted as a semi-strict feedback form. In the differential braking control problem under the driver torque, a matching condition does not satisfy, and the system is not in the form of, the strict feedback form. Thus, a general backstepping control method cannot be applied. To overcome this problem, the proposed method is designed via the combination of the sliding mode control and backstepping. Two sliding surfaces are designed for differential braking control. One of the surfaces is designed considering the lateral offset error, and the other sliding surface is designed using the combination of the yaw and yaw rate errors as the virtual input of the lateral offset error dynamics. A brake steer force input is developed to regulate the two sliding surfaces using a backstepping procedure under the driver torque. Integral action and a super twisting algorithm are used in the lateral controller to ensure the robustness of the system. The proposed method, which is designed via the combination of the sliding mode control and backstepping, can improve the lateral control performance using differential braking. The proposed method is validated through simulations. | Son, Young Seop; Kim, Wonhee | Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, Daegu 70270, South Korea; Chung Ang Univ, Sch Energy Syst Engn, Seoul 156756, South Korea | ; Kim, Wonhee/AAJ-9848-2020 | 35203958300; 34770809600 | ys.son@knu.ac.kr;whkim79@cau.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 14 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.55 | 2025-07-30 | 3 | 4 | differential braking; backstepping control | BACKSTEPPING CONTROL; AUTOMATED VEHICLES; LATERAL CONTROL | Backstepping control; Differential braking | English | 2021 | 2021-07 | 10.3390/math9141699 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Numerical evaluation of the performance of injection/extraction well pair operation strategies with temporally variable injection/pumping rates | In general, in situ remediation techniques require that treatment agents come into contact with contaminants to facilitate the treatment process. Greater contact causes more in situ mixing of the two compounds and greater contaminant reduction. In a recirculation well system featuring an injection/extraction well pair, delivery controls the remedial and economic efficiency of decontamination, and is therefore a key consideration for successful in situ remediation. In this study, we numerically evaluated the remedial and economic efficiency of a recirculation well system with sinusoidal temporally varying pumping and injection rates for enhancing remediation; the results were compared with those of a traditional recirculation well system with constant injection/extraction rates. We performed sensitivity analyses to determine the optimal values of four operational parameters associated with the effects of temporally variable pumping or injection rates on the cumulative swept area of injected chemical amendment for a given operation time or cumulative injected volume, which are good measures of remediation and economic efficiency. The findings of this study provide insight into the mechanical process of plume spreading in response to injection/pumping operational strategies, and demonstrate that enhanced plume spreading is a key requirement for achieving sufficient contact between chemical amendments and contaminants. | Suk, Heejun; Chen, Jui-Sheng; Park, Eungyu; Han, Weon Shik; Kihm, You Hong | Korea Inst Geosci & Mineral Resources, Daejeon 34132, South Korea; Natl Cent Univ, Grad Inst Appl Geol, Taoyuan 320, Taiwan; Kyungpook Natl Univ, Dept Geol, 80 Daehak Ro, Daegu 41566, South Korea; Yonsei Univ, Dept Earth Syst Sci, 50 Yonsei Ro, Seoul 03722, South Korea | Han, Weon Shik/KCY-0126-2024 | 23996203400; 7501893250; 23995577700; 57226420125; 6504341152 | juischen@ncu.edu.tw; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 598 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2021 | 6.708 | 6.2 | 1.13 | 2025-07-30 | 18 | 17 | Constant injection/pumping rates; Economic efficiency of remediation; Injection/extraction well pair; Recirculation well system; Sinusoidal temporally varying pumping and injection rates | GROUNDWATER-FLOW; ANALYTICAL-MODEL; CAPTURE ZONES; EXTRACTION; IMPLEMENTATION; TRANSPORT; DESIGN; SYSTEM; FIELD | Constant injection/pumping rates; Economic efficiency of remediation; Injection/extraction well pair; Recirculation well system; Sinusoidal temporally varying pumping and injection rates | Chemical analysis; Petroleum reservoir evaluation; Pollution; Pumps; Sensitivity analysis; Constant injection/pumping rate; Economic efficiency; Economic efficiency of remediation; In-situ remediation; Injection/extraction well pair; Injection/extraction wells; Pumping rate; Recirculation well system; Recirculations; Sinusoidal temporally varying pumping and injection rate; economic analysis; efficiency measurement; extraction method; in situ measurement; numerical model; pollutant; pumping; Efficiency | English | 2021 | 2021-07 | 10.1016/j.jhydrol.2021.126494 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Probabilistic flood hazard assessment method considering local intense precipitation at NPP sites | In recent years, the flooding risk of major facilities has increased significantly due to heavy rainfall events. These facilities must evaluate both external and internal flooding risk such as from heavy rainfall, flash floods, watershed flooding, river flooding, and coastal flooding. This study first estimates flooding from extreme rainfall with local intense precipitation and analyzes the resulting impacts on buildings and roads at a specific nuclear power plant (NPP) site, with which a roughness coefficient according to the landuse condition is estimated. A two-dimensional external flooding hazard analysis is then carried out with tidal levels as the external boundary conditions, and based on the results, new hazard curves for the inundation depth with frequency and duration are developed for the NPP site to show the relationships among rainfall, flood depth, and annual exceedance probability. To match the proper probability distribution types to the flood hazard curves, the fit was analyzed through Akaike's information criterion verification. After analyzing the correlation between the flood depths, the mode values were calculated through Monte Carlo simulation with the verified probability distribution types. Finally, probabilistic flood hazard curves for the NPP site were obtained based on the calculated mode values. Representatively, when a 10(6)-year return period rainfall occurs at the nuclear power plant site, the mode flood depth was found to be 1.07 m for power plant 1 and 0.61 m for power plant 2. In this way, the approach of this study is expected to support the waterproof design of critical facilities, flood prevention function design, the advancement of flood prevention measures and procedures, and the evaluation of flood mitigation functions. | Kim, Beom-Jin; Kim, Minkyu; Hahm, Daegi; Han, Kun Yeun | Korea Atom Energy Res Inst, Smart Struct Safety & Prognosis Res Div, Daejeon, South Korea; Kyungpook Natl Univ, Dept Civil Engn, Daegu 41566, South Korea | diamond982@naver.com;minkyu@kaeri.re.kr;dhahm@kaeri.re.kr;kshanj@knu.ac.kr; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 597 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2021 | 6.708 | 6.2 | 5 | Local intense precipitation (LIP); Runoff analysis; External flood analysis; Probabilistic model; Probabilistic flood hazard assessment (PFHA) | SAFETY ASSESSMENT | English | 2021 | 2021-06 | 10.1016/j.jhydrol.2021.126192 | 바로가기 | 바로가기 | 바로가기 | |||||||||||
| ○ | ○ | Article | Robust Nonlinear Position Control with Extended State Observer for Single-Rod Electro-Hydrostatic Actuator | In the existing literature, studies on position controller design using only position feedback, considering the disturbances for single-rod electro-hydrostatic actuators (EHAs), have not been reported. Herein, we propose a robust nonlinear position control with an extended state observer (ESO) for single-rod EHAs. A new EHA model that consists of position, velocity, and acceleration with an internal state variable is developed. Instead of the separated port pressure dynamics, the acceleration dynamics were defined. The external disturbance, model, and input function uncertainties were lumped into a disturbance. An ESO is developed to estimate the disturbance, as well as the position, velocity, and acceleration. In practice, it is difficult to accurately estimate the disturbance because it includes the external disturbance, system dynamics, and input function uncertainty. The poor estimation performance may degrade the position tracking performance, but a high gain cannot be used to suppress the estimation error because of the measurement noise amplification. To resolve this problem, a robust nonlinear position controller is developed via a backstepping procedure. In the controller, a nonlinear gain is implemented to sufficiently suppress position tracking without the use of a high gain. The stability of the closed-loop system is mathematically proven using the input-to-state stability. The proposed method is simple and suitable for real-time control. | Son, Young Seop; Kim, Wonhee | Kyungpook Natl Univ, Dept Robot & Smart Syst Engn, Daegu 702701, South Korea; Chung Ang Univ, Sch Energy Syst Engn, Seoul 156756, South Korea | Kim, Wonhee/AAJ-9848-2020 | 35203958300; 34770809600 | ys.son@knu.ac.kr;whkim79@cau.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 19 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.14 | 2025-07-30 | 1 | 1 | electro-hydrostatic actuator; position measurement; state estimation; position control | TRACKING CONTROL; MOTION CONTROL; SYSTEM; DESIGN; SERVO | Electro-hydrostatic actuator; Position control; Position measurement; State estimation | English | 2021 | 2021-10 | 10.3390/math9192397 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Effects of steroid therapy in patients with severe fever with Thrombocytopenia syndrome: A multicenter clinical cohort study | Background Severe fever with thrombocytopenia syndrome (SFTS) is an acute, febrile, and potentially fatal tick-borne disease caused by the SFTS Phlebovirus. Here, we evaluated the effects of steroid therapy in Korean patients with SFTS. Methods A retrospective study was performed in a multicenter SFTS clinical cohort from 13 Korean university hospitals between 2013 and 2017. We performed survival analysis using propensity score matching of 142 patients with SFTS diagnosed by genetic or antibody tests. Results Overall fatality rate was 23.2%, with 39.7% among 58 patients who underwent steroid therapy. Complications were observed in 37/58 (63.8%) and 25/83 (30.1%) patients in the steroid and non-steroid groups, respectively (P 5 days), and non-steroid groups, were 18.4, 22.4, and 27.3 days, respectively (P = .005). Conclusions After steroid therapy, an increase in complications was observed among patients with SFTS. Steroid therapy should be used with caution, considering the possible negative effects of steroid therapy within 5 days of symptom onset or in patients with mild disease (APACHE II score <14). Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an acute, febrile, and potentially fatal tick-borne disease caused by the SFTS Phlebovirus. Here, we evaluated the effects of steroid therapy in Korean patients with SFTS. We performed survival analysis using propensity score matching of 142 patients with SFTS diagnosed by genetic or antibody tests. In patients with SFTS, steroid therapy should be used with caution, considering the possible negative effects of steroid therapy within 5 days of symptom onset or in patients with mild disease (APACHE II score <14). | Jung, Sook In; Kim, Ye Eun; Yun, Na Ra; Kim, Choon-Mee; Kim, Dong-Min; Han, Mi Ah; Kim, Uh Jin; Kim, Seong Eun; Kim, Jieun; Ryu, Seong Yeol; Kim, Hyun Ah; Hur, Jian; Kim, Young Keun; Jeong, Hye Won; Heo, Jung Yeon; Jung, Dong Sik; Lee, Hyungdon; Huh, Kyungmin; Kwak, Yee Gyung; Lee, Sujin; Lim, Seungjin; Lee, Sun Hee; Park, Sun Hee; Yeom, Joon-Sup; Kim, Shin-Woo; Bae, In-Gyu; Lee, Juhyung; Kim, Eu Suk; Seo, Jun-Won | Chonnam Natl Univ, Dept Internal Med, Med Sch, Gwangju, South Korea; Chosun Univ, Coll Med, Dept Nursing, Gwangju, South Korea; Chosun Univ, Coll Med, Dept Internal Med, Gwangju, South Korea; Chosun Univ, Coll Med, Dept Prevent Med, Gwangju, South Korea; Hanyang Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Keimyung Univ, Div Infect Dis, Dongsan Med Ctr, Daegu, South Korea; Yeungnam Univ, Dept Internal Med, Med Ctr, Daegu, South Korea; Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Ajou Univ, Sch Med, Dept Infect Dis, Suwon, South Korea; Dong A Univ, Dept Internal Med, Coll Med, Busan, South Korea; Hallym Univ, Coll Med, Dept Internal Med, Chunchon, South Korea; Samsung Med Ctr, Dept Med, Div Infect Dis, Seoul, South Korea; Inje Univ, Dept Internal Med, Ilsan Paik Hosp, Goyang, South Korea; Pusan Natl Univ, Coll Med, Dept Internal Med, Yangsan, South Korea; Pusan Natl Univ, Pusan Natl Univ Hosp, Dept Internal Med, Sch Med, Busan, South Korea; Catholic Univ Korea, Coll Med, Dept Internal Med, Div Infect Dis, Daejeon, South Korea; Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Gyeongsang Natl Univ, Coll Med, Dept Internal Med, Jinju, South Korea; Jeonbuk Natl Univ, Dept Prevent Med, Med Sch, Jeonju, South Korea; Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea | ; Kim, Nam-Joong/J-2735-2012; Kim, Seog/J-5403-2012; kim, dongmin/MEO-8165-2025; LEE, SUN HEE/AAB-5714-2022; JUNG, SOOK IN/AGO-2862-2022; Kim, Ik-Sang/J-5425-2012; Kim, Young/H-4235-2013; Kim, Ju-Hyoung/N-1450-2019; Yeom, Joon/Q-5559-2019; Jung, Dong Sik/HOH-5826-2023; Jeong, Hye/AET-1982-2022 | 7403676835; 57222392213; 36237230600; 57205238613; 39861468000; 56504367800; 55606990600; 57226683401; 51963871600; 9733513600; 57059615500; 19934047300; 35322538300; 13103042700; 24587525000; 14023089600; 57221330200; 55569009500; 7103120454; 58377458300; 55633469300; 56498686800; 57208684295; 7004196941; 8710731500; 7004882611; 7601476476; 22938086900; 57189901863 | drongkim@chosun.ac.kr; | PLOS NEGLECTED TROPICAL DISEASES | PLOS NEGLECT TROP D | 1935-2735 | 15 | 2 | SCIE | PARASITOLOGY;TROPICAL MEDICINE | 2021 | 4.781 | 6.3 | 2.7 | 2025-07-30 | 34 | 35 | SYNDROME VIRUS; SOUTH-KOREA; GLUCOCORTICOIDS; DEATH; TICKS | Aged; Cohort Studies; Female; Humans; Male; Middle Aged; Phlebovirus; Retrospective Studies; Risk Factors; Severe Fever with Thrombocytopenia Syndrome; Steroids; Survival Analysis; Tick-Borne Diseases; alanine aminotransferase; albumin; aspartate aminotransferase; dexamethasone; hemoglobin; hydrocortisone; immunoglobulin G; immunoglobulin M; lactate dehydrogenase; methylprednisolone; prednisolone; ribavirin; sodium; steroid; aged; altered state of consciousness; APACHE; Article; artificial ventilation; body temperature; case fatality rate; cohort analysis; continuous renal replacement therapy; female; heart arrhythmia; hematocrit; hemodialysis; hospitalization; human; immunofluorescence assay; intensive care unit; Korean (people); leukocyte count; major clinical study; male; multicenter study; nested polymerase chain reaction; plasmapheresis; platelet count; pneumonia; propensity score; real time polymerase chain reaction; retrospective study; septic shock; severe fever with thrombocytopenia syndrome; steroid therapy; survival analysis; survival time; therapy effect; urea nitrogen blood level; virus detection; clinical trial; middle aged; Phlebovirus; risk factor; severe fever with thrombocytopenia syndrome; tick borne disease | English | 2021 | 2021-02 | 10.1371/journal.pntd.0009128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis | Background and Purpose: The promotion of hair regeneration and growth heavily depends on the activation of Wnt/beta-catenin signalling in the hair follicle, including dermal papilla (DP). KY19382, one of the newly synthesized analogues of indirubin-3 '-monoxime (I3O), was identified as a Wnt/beta-catenin signalling activator via inhibition of the interaction between CXXC-type zinc finger protein 5 (CXXC5) and dishevelled (Dvl). Given the close relationship between the Wnt/beta-catenin signalling and hair regeneration, we investigated the effect of KY19382 on hair regrowth and hair follicle neogenesis. Experimental Approach: In vitro hair induction effects of KY19382 were performed in human DP cells. The hair elongation effects of KY19382 were confirmed through the human hair follicle and vibrissa culture system. In vivo hair regeneration abilities of KY19382 were identified in three models: hair regrowth, wound-induced hair follicle neogenesis (WIHN) and hair patch assays using C57BL/6 mice. The hair regeneration abilities were analysed by immunoblotting, alkaline phosphatase (ALP) and immunohistochemical staining. Key Results: KY19382 activated Wnt/beta-catenin signalling and elevated expression of ALP and the proliferation marker PCNA in DP cells. KY19382 also increased hair length in ex vivo-cultured mouse vibrissa and human hair follicles and induced hair regrowth in mice. Moreover, KY19382 significantly promoted the generation of de novo hair follicles as shown by WIHN and hair patch assays. Conclusion and Implications: These results indicate that KY19382 is a potential therapeutic drug that exhibits effective hair regeneration ability via activation of the Wnt/beta-catenin signalling for alopecia treatments. | Ryu, Yeong Chan; Lee, Dong-Hwan; Shim, Jiyong; Park, Jiyeon; Kim, You-Rin; Choi, Sehee; Bak, Soon Sun; Sung, Young Kwan; Lee, Soung-Hoon; Choi, Kang-Yell | Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, 134 Shinchon Dong, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Med, Dept Immunol, Daegu, South Korea; CK Biotech Inc, Engn Res Pk, Seoul, South Korea | ; Shim, Jiyong/KVB-6266-2024; Lee, Seung/AAI-1191-2020 | 57223200034; 57196151570; 57201744861; 57223193489; 57223191022; 57157690200; 41561065700; 55663365300; 26322530000; 7403949379 | sexyondal@gmail.com;kychoi@yonsei.ac.kr; | BRITISH JOURNAL OF PHARMACOLOGY | BRIT J PHARMACOL | 0007-1188 | 1476-5381 | 178 | 12 | SCIE | PHARMACOLOGY & PHARMACY | 2021 | 9.473 | 6.3 | 3.05 | 2025-07-30 | 54 | 52 | CXXC5; dermal papilla cells; GSK-3 beta; neogenesis; Wnt/beta-catenin signalling | DERMAL PAPILLA CELLS; GROWTH IN-VITRO; ANDROGENETIC ALOPECIA; BONE LOSS; WNT; MORPHOGENESIS; ACID; INDIRUBIN-3'-OXIME; DIFFERENTIATION; REGENERATION | CXXC5; dermal papilla cells; GSK-3β; neogenesis; Wnt/β-catenin signalling | Animals; beta Catenin; Hair; Hair Follicle; Mice; Mice, Inbred C57BL; Wnt Signaling Pathway; alkaline phosphatase; beta catenin; dermatological agent; ky 19382; unclassified drug; Wnt protein; beta catenin; animal tissue; Article; C57BL 6 mouse; C57BL/6N mouse; cell proliferation; cell viability; clinical effectiveness; controlled study; drug effect; drug efficacy; drug mechanism; drug response; ex vivo study; hair follicle; hair growth; human; human tissue; immunoblotting; immunohistochemistry; in vitro study; in vivo study; male; mouse; nonhuman; papillary dermis; priority journal; protein expression; rat; signal transduction; tissue regeneration; Wistar rat; animal; C57BL mouse; hair; metabolism; Wnt signaling | English | 2021 | 2021-06 | 10.1111/bph.15438 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Predictors of Remission and Relapse of Diabetes after Conventional Gastrectomy for Gastric Cancer: Nationwide Population-Based Cohort Study | BACKGROUND: We investigated whether preoperative clinical parameters predict diabetes remission and relapse after conventional gastrectomy for cancer and whether postoperative weight changes influence diabetes remission and relapse. STUDY DESIGN: This study included 5,150 patients with diabetes who underwent gastrectomy for cancer from 2004 to 2014. Diabetes remission was defined in 3 ways, according to postoperative antidiabetic medication and fasting plasma glucose (FPG) levels. Diabetes relapse was defined as reinitiating antidiabetic medication among patients in diabetes remission. RESULTS: Six predictors (higher body mass index [BMI], total gastrectomy, younger age, FPG levels, number of oral hypoglycemic agents [OHAs], and no insulin use) of diabetes remission increased the likelihood of remission by >13-fold (odds ratio [OR], 13.67; 95% confidence interval [CI], 8.65-19.11). Three factors (younger age, lower FPG levels, and use of only 1 OHA) predicted a 58% decreased likelihood of diabetes relapse (hazard ratio, 0.42; 95% CI 0.35-0.48). The lowest interval of postoperative BMI decrease (3-fold increased likelihood of diabetes remission than the highest interval (>=-5%; OR 3.14; 95% CI 2.08-4.75), independent of baseline BMI. CONCLUSIONS: Six variables (BMI, type of gastrectomy, age, FPG levels, number of OHAs used, and insulin use/non-use), and 3 variables (age, FPG levels, number of OHAs used) significantly predict diabetes remission and relapse after gastrectomy for cancer, respectively. Greater postoperative weight decrease may increase the likelihood of diabetes remission, independent of baseline weight. Our results may serve as a basis for the establishment of diabetes and weight management strategies after conventional gastrectomy for cancer. ((C) 2021 by the American College of Surgeons. Published by Elsevier Inc. All rights reserved.) | Kwon, Yeongkeun; Kwon, Jin-Won; Kim, Dohyang; Ha, Jane; Park, Shin-Hoo; Hwang, Jinseub; Heo, Yoonseok; Park, Sungsoo | Korea Univ, Coll Med, Div Foregut Surg, 73 Goryeodae Ro, Seoul 02841, South Korea; Korea Univ, Anam Hosp, Seoul, South Korea; Kyungpook Natl Univ, Inst Pharmaceut Sci, Coll Pharm & Res, BK21 Four Community Based Intelligent Novel Drug, Daegu, South Korea; Daegu Univ, Dept Stat, Gyeongbuk, South Korea; Inha Univ, Dept Surg, Sch Med, Incheon, South Korea | Park, Sun-Young/B-4634-2014 | 55970203000; 16202951700; 57218821860; 57217000677; 57188744111; 57189231296; 39361359300; 57187346700 | kugspss@korea.ac.kr; | JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS | J AM COLL SURGEONS | 1072-7515 | 1879-1190 | 232 | 6 | SCIE | SURGERY | 2021 | 6.532 | 6.3 | 0.57 | 2025-07-30 | 8 | 5 | BODY-MASS INDEX; BARIATRIC SURGERY; METABOLIC SURGERY; MORTALITY | Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastrectomy; Humans; Hypoglycemic Agents; Incidence; Male; Middle Aged; Postoperative Period; Recurrence; Republic of Korea; Retrospective Studies; Stomach Neoplasms; Treatment Outcome; Weight Loss; 2,4 thiazolidinedione derivative; alkylating agent; alpha glucosidase inhibitor; antineoplastic antibiotic; antineoplastic antimetabolite; biguanide derivative; dipeptidyl peptidase IV inhibitor; DNA topoisomerase inhibitor; glucose; insulin; meglitinide; monoclonal antibody; oral antidiabetic agent; sulfonylurea derivative; antidiabetic agent; adjuvant therapy; age; aged; Article; body mass; body weight change; body weight loss; body weight management; cancer patient; cohort analysis; diabetes mellitus; diabetic patient; fasting; female; gastrectomy; glucose blood level; human; incidence; major clinical study; male; population research; postoperative period; predictor variable; priority journal; relapse; remission; stomach cancer; total stomach resection; adverse event; blood; body weight loss; follow up; gastrectomy; middle aged; non insulin dependent diabetes mellitus; procedures; recurrent disease; retrospective study; South Korea; stomach tumor; treatment outcome | English | 2021 | 2021-06 | 10.1016/j.jamcollsurg.2021.03.019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis of N-Trifluoromethanesulfinyl Ketimines by Cascade Trifluoromethylthiolation/Rearrangement of Ketoximes | A new and efficient cascade electrophilic trifluoro-methylthiolation/radical rearrangement reaction of ketoximes is reported using N-trifluoromethylthio-dibenzenesulfonimide as the SCF3 source without any additives. This simple one-pot reaction provides the corresponding N-trifluoromethanesulfinyl ketimine products in good yields with high E selectivity under mild reaction conditions. | Kim, Bora; Park, Junho; Cho, Chang-Woo | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | Bin Kim, Hong/J-5452-2012 | 57211371068; 57224861361; 7403100021 | cwcho@knu.ac.kr; | ORGANIC LETTERS | ORG LETT | 1523-7060 | 1523-7052 | 23 | 12 | SCIE | CHEMISTRY, ORGANIC | 2021 | 6.072 | 6.3 | 0.48 | 2025-07-30 | 7 | 8 | CF3SO2X X; FLUORINE; SULFINYL; TRIFLUOROMETHYLATION; GENERATION; RADICALS; REAGENTS; PHARMACEUTICALS; CYCLIZATION; SULFOXIDES | article; electrophilicity; one pot synthesis; reaction analysis | English | 2021 | 2021-06-18 | 10.1021/acs.orglett.1c01338 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Trends in End-of-Life Resource Utilization and Costs among Prostate Cancer Patients from 2006 to 2015: A Nationwide Population-Based Study | Purpose: The purpose of this study was to evaluate end-of-life resource utilization and costs for prostate cancer patients during the last year of life in Korea. Materials and Methods:The study used the National Health Information Database (NHIS-2017-4-031) of the Korean National Health Insurance Service. Healthcare claim data for the years 2002 through 2015 were collected from the Korean National Health Insurance System. Among 83,173 prostate cancer patients, we enrolled 18,419 after excluding 1,082 who never claimed for the last year of life. Results: From 2006 to 2015, there was a 3.2-fold increase the total number of prostate cancer decedents. The average cost of care during the last year of life increased over the 10-year period, from 14,420,000 Korean won to 20,300,000 Korean won, regardless of survival time. The cost of major treatments and medications, other than analgesics, was relatively high. Radiologic tests, opioids, pain control, and rehabilitation costs were relatively low. Multiple regression analysis identified age and living in rural area as negatively associated with prostate cancer care costs, whereas income level and a higher number of comorbidities were positively associated. Conclusions: Expenditure of prostate cancer care during the last year of life varied according to patient characteristics. Average costs increased every year. However, the results suggest underutilization of support services, likely due to lack of alternative accommodation for temiinal prostate cancer patients. Further examination of patterns of utilization of healthcare resources will allow policymakers to take a better approach to reducing the burden of prostate cancer care. | Ha, Yun-Sok; Kim, So-Young; Chung, Jae Il; Choi, Hoon; Kim, Jae Heon; Yu, Ho Song; Cho, In-Chang; Kim, Hyung Joon; Chung, Hyun Chul; Koh, Jun Sung; Lee, Ji Youl; Park, Dong Jin; Kim, Hyun Tae; Yoo, Eun Sang; Kwon, Tae Gyun; Min, Kyungchan; Kim, Wun-Jae; Yun, Seok Joong; Park, Jong-Hyock | Kyungpook Natl Univ, Sch Med, Dept Urol, Daegu, South Korea; Chungbuk Natl Univ Hosp, Dept Publ Hlth & Prevent Med, Cheongju, South Korea; Inje Univ, Busan Paik Hosp, Dept Urol, Busan, South Korea; Korea Univ, Ansan Hosp, Dept Urol, Coll Med, Ansan, South Korea; Soonchunhyang Univ, Dept Urol, Seoul Hosp, Seoul, South Korea; Chonnam Natl Univ, Med Sch, Dept Urol, Gwangju, South Korea; Natl Police Hosp, Dept Urol, Seoul, South Korea; Konyang Univ, Dept Urol, Coll Med, Daejeon, South Korea; Yonsei Univ, Dept Urol, Wonju Coll Med, Wonju, South Korea; Catholic Univ Korea, Coll Med, Bucheon St Marys Hosp, Dept Urol, Seoul, South Korea; Catholic Univ Korea, Coll Med, Dept Urol, Seoul St Marys Hosp, Seoul, South Korea; Dongguk Univ, Dept Urol, Sch Med, Gyeongju, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Urol, Coll Med, 776 1Sunhwan Ro, Cheongju 28644, South Korea; Chungbuk Natl Univ, Grad Sch Hlth Sci Business Convergence, Coll Med, Inst Urotech, Cheongju, South Korea; Chungbuk Natl Univ, Grad Sch Hlth Sci Business Convergence, Coll Med, Dept Prevent Med, 52 Naesudong Ro, Cheongju 28644, South Korea | ; Kim, Jihun/GRY-3648-2022; Kim, Jae-hyung/J-8504-2012; Kim, Hyung Joon/F-6497-2013; Tae, Bum Sik/JRY-8920-2023; Kim, So Young/AET-2590-2022 | sjyun@chungbuk.ac.kr;jonghyock@chungbuk.ac.kr; | WORLD JOURNAL OF MENS HEALTH | WORLD J MENS HEALTH | 2287-4208 | 2287-4690 | 39 | 1 | SCIE | ANDROLOGY;UROLOGY & NEPHROLOGY | 2021 | 6.494 | 6.3 | 8 | Health care costs; Healthcare utilization; Prostatic neoplasms; Terminal care | MEDICAL-CARE; LAST YEAR; PALLIATIVE CARE; KOREAN MEN; MITOXANTRONE; PREDNISONE; PREDICTOR; DOCETAXEL; INCOME; INDEX | English | 2021 | 2021-01 | 10.5534/wjmh.200113 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Atherosclerotic Burden and Vascular Risk in Stroke Patients With Atrial Fibrillation | Background and Purpose: Data on the effect on vascular outcomes of concomitant atherosclerotic vascular disease (ASVD) with atrial fibrillation (AF) after stroke are limited. This study evaluated the effect of ASVD with AF versus AF only on the risk of vascular events. Methods: We retrospectively analyzed a prospectively registered multicenter database involving 3213 stroke patients with AF. ASVD included extracranial atherosclerosis measured in the proximal portion of the internal carotid artery, intracranial atherosclerosis (all >= 50% stenosis), coronary artery disease, and peripheral artery disease and was categorized into 4 strata depending on the number of ASVDs (0, 1, 2, and 3-4). The independent associations of ASVD with major adverse cardiovascular events, stroke, and all-cause death were assessed. Results: A total of 2670 patients were included (mean age, 73.5 +/- 9.8 years; median CHA(2)DS(2)-VASc score, 5; interquartile range, 4-6). During the follow-up (mean, 1.7 years), a total of 672 (25.2%) major adverse cardiovascular events, 170 (6.4%) stroke events, and 501 (18.8%) all-cause deaths were noted. The adjusted hazard ratio for major adverse cardiovascular events versus no ASVD was 1.25 (95% CI, 1.00-1.56) for ASVD 1, 1.34 (95% CI, 1.02-1.76) for ASVD 2, and 1.93 (95% CI, 1.24-2.99) for ASVD 3-4. The adjusted hazard ratio for all-cause death versus no ASVD was 1.32 (1.01-1.74), 1.47 (1.06-2.03), and 2.39 (1.47-3.89), respectively. Among ASVD components, the presence of symptomatic or asymptomatic extracranial atherosclerosis was a more potent predictor of major adverse cardiovascular events (1.27 [1.05-1.54]) and all-cause death (1.45 [1.17-1.81]). Conclusions: ASVD burden with AF can be a cumulative marker of a high risk for untoward vascular outcomes. Among ASVD components, extracranial atherosclerosis seems to have a predominant effect. | Park, Jong-Ho; Chung, Jong-Won; Bang, Oh Young; Kim, Gyeong-Moon; Choi, Kang-Ho; Park, Man-Seok; Kim, Joon-Tae; Hwang, Yang-Ha; Song, Tae-Jin; Kim, Yong-Jae; Kim, Bum Joon; Heo, Sung Hyuk; Jung, Jin-Man; Oh, Kyungmi; Kim, Chi Kyung; Yu, Sungwook; Park, Kwang Yeol; Kim, Jeong-Min; Choi, Jay Chol; Seo, Woo-Keun | Hanyang Univ, Myongji Hosp, Dept Neurol, Coll Med, 55 Hwasuro 14beon Gil, Goyang 10475, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Sch Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Neurol, Gwangju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Ewha Womans Univ, Coll Med, Dept Neurol, Seoul Hosp, Seoul, South Korea; Catholic Univ Korea, Dept Neurol, Eunpyeong St Marys Hosp, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Dept Neurol, Coll Med, Seoul, South Korea; Kyung Hee Univ, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Dept Neurol, Ansan Hosp, Coll Med, Seoul, South Korea; Korea Univ, Guro Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Korea Univ, Anam Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Chung Ang Univ, Dept Neurol, Coll Med, Seoul, South Korea; Seoul Natl Univ Hosp, Dept Neurol, Seoul, South Korea; Jeju Natl Univ, Dept Neurol, Jeju City, South Korea | ; HWANG, Yang-Ha/F-3068-2013; Kim, Yong-Jae/JQW-5758-2023; Kim, Jeong-Min/ABH-2469-2021; choi, jo/O-5940-2014; Jung, Jin-Man/LJL-8037-2024; Heo, Sung/P-3529-2019; Kim, Dong/AAH-2257-2021; Choi, Kangho/HKV-1503-2023; Kim, Chi/AAR-9819-2020 | 55716977200; 55553751200; 7006620221; 35237139600; 36491173100; 7404490852; 23667663000; 7402311308; 55507164200; 55865497600; 57214661365; 18835720200; 15755814800; 16048029600; 56701057800; 56144716300; 36060099300; 7601375827; 7501392645; 22981667600 | jhpark619@hanyang.ac.kr;mcastenosis@gmail.com; | STROKE | STROKE | 0039-2499 | 1524-4628 | 52 | 5 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2021 | 10.17 | 6.4 | 0.96 | 2025-07-30 | 14 | 11 | atherosclerotic disease; atrial fibrillation; carotid artery stenosis; outcome; stroke | CAROTID ATHEROSCLEROSIS; ISCHEMIC-STROKE; ARTERY-DISEASE; VITAMIN-D; PREVENTION; OUTCOMES; EVENTS; SCORE | atherosclerotic disease; atrial fibrillation; carotid artery stenosis; outcome; stroke | Aged; Aged, 80 and over; Atrial Fibrillation; Coronary Artery Disease; Databases, Factual; Female; Humans; Intracranial Arteriosclerosis; Male; Middle Aged; Peripheral Arterial Disease; Retrospective Studies; Risk Factors; Stroke; aged; atrial fibrillation; brain atherosclerosis; cerebrovascular accident; clinical trial; complication; coronary artery disease; factual database; female; human; male; middle aged; mortality; multicenter study; pathophysiology; peripheral occlusive artery disease; retrospective study; risk factor; very elderly | English | 2021 | 2021-05 | 10.1161/strokeaha.120.032232 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Revisiting the Proportional Recovery Model in View of the Ceiling Effect of Fugl-Meyer Assessment | Background and Purpose: The aim of this study was to verify the validity of the proportional recovery model in view of the ceiling effect of the Fugl-Meyer Assessment. Methods: We reviewed the medical records of patients enrolled in the Korean Stroke Cohort for Functioning and Rehabilitation between August 2012 and May 2015. Recovery proportion was defined as the actual change in Fugl-Meyer Assessment score of the upper extremity between 7 days and 6 months poststroke, relative to the initial neurological impairment. We then used logistic regression to identify clinical factors attributable to a ceiling effect of the Fugl-Meyer Assessment score of the upper extremity and propensity score matching to verify the validity of the proportional recovery rule. Results: We screened 10 636 patients and analyzed 849 patients (mean age, 65.4 +/- 11.9 years; female, 320 [37.7%]) with first-ever ischemic stroke. We found, through logistic regression analysis, that a one-unit increase in the initial neurological impairment and the age at stroke onset affected the odds ratio (1.0386 and 0.9736, respectively) of achieving the full Fugl-Meyer Assessment score of the upper limb at 6 months poststroke. We also demonstrated, through propensity score matching, that the difference in initial neurological impairment of the upper extremity resulted in discrepancy of the recovery proportion (0.92 +/- 0.20 [0-1] versus 0.81 +/- 0.31 [0-1], P<0.001). Conclusions: We demonstrated that the ceiling effect of the Fugl-Meyer Assessment score of the upper extremity is pronounced in patients with mild initial motor deficits of the upper extremity and that the recovery proportion varies according to the initial motor deficit of the upper limb using logistic regression analysis and propensity score matching, respectively. These results suggest that the proportional recovery model is not valid. | Lee, Hyun Haeng; Kim, Deog Young; Sohn, Min Kyun; Shin, Yong-Il; Oh, Gyung-Jae; Lee, Yang-Soo; Joo, Min Cheol; Lee, So Young; Han, Junhee; Ahn, Jeonghoon; Chang, Won Hyuk; Kim, Ilyoel; Mi Choi, Soo; Lee, Jongmin; Kim, Yun-Hee | Konkuk Univ, Sch Med, Med Ctr, Dept Rehabil Med, Seoul, South Korea; Yonsei Univ, Coll Med, Res Inst Rehabil Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept, Seoul, South Korea; Chungnam Natl Univ, Sch Med, Dept Rehabil Med, Daejeon, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Rehabil Med, Pusan, South Korea; Wonkwang Univ, Sch Med, Dept Prevent Med, Iksan, South Korea; Wonkwang Univ, Sch Med, Dept Rehabil Med, Iksan, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Rehabil Med, Daegu, South Korea; Jeju Natl Univ, Sch Med, Jeju Natl Univ Hosp, Dept Rehabil Med, Jeju, South Korea; Hallym Univ, Inst Stat, Chunchon, South Korea; Hallym Univ, Dept Stat, Chunchon, South Korea; Ewha Womans Univ, Dept Hlth Convergence, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Heart Vasc Stroke Inst,Dept Phys & Rehabil Med, Irwon Ro 115, Seoul 06355, South Korea; Korea Ctr Dis Control & Prevent, Ctr Dis, Div Chron Dis Prevent, Cheongju, South Korea; Sungkyunkwan Univ, SAIHST, Dept Med Device Management & Res, Dept Digital Hlth,Dept Hlth Sci & Technol, Irwon Ro 115, Seoul 06355, South Korea | Lee, Jongmin/Q-4909-2019; Ahn, Jeonghoon/CAA-1956-2022; kim, deog young/Q-8498-2019; Kim, Yun-Hee/GVS-6426-2022 | 57221571161; 55375583000; 7101840459; 55890990500; 7007056685; 57202952463; 56982599700; 57202327370; 57192890252; 8855402200; 35301717900; 57214361107; 57253230100; 57202882113; 57020121600 | leej@kuh.ac.kr;yun1225.kim@samsung.com;mksohn@cnu.ac.kr;rmshin@pusan.ac.kr;pmokj@wku.ac.kr;jmc77@daum.net;hanjh@hallym.ac.kr;ahnjeonghoon@ewha.ac.kr;wh.chang@samsung.com;choism7334@korea.kr; | STROKE | STROKE | 0039-2499 | 1524-4628 | 52 | 10 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2021 | 10.17 | 6.4 | 1.17 | 2025-07-30 | 15 | 14 | brain ischemia; ischemic stroke; medical records; rehabilitation; upper extremity | MOTOR EVOKED-POTENTIALS; ISCHEMIC BRAIN-INJURY; CORTICOSPINAL TRACT; UPPER-EXTREMITY; POSTSTROKE REORGANIZATION; FOLLOW-UP; STROKE; HAND; AREA; IMPAIRMENT | brain ischemia; ischemic stroke; medical records; rehabilitation; upper extremity | Adult; Aged; Aged, 80 and over; Cohort Studies; Disability Evaluation; Evoked Potentials; Female; Humans; Ischemic Stroke; Male; Middle Aged; Models, Theoretical; Propensity Score; Recovery of Function; Republic of Korea; Stroke; Stroke Rehabilitation; Treatment Outcome; Upper Extremity; Young Adult; adult; aged; brain ischemia; cerebrovascular accident; cohort analysis; convalescence; disability; evoked response; female; human; male; middle aged; pathophysiology; propensity score; South Korea; stroke rehabilitation; theoretical model; treatment outcome; upper limb; very elderly; young adult | English | 2021 | 2021-10 | 10.1161/strokeaha.120.032409 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Ibrutinib modulates Aβ/tau pathology, neuroinflammation, and cognitive function in mouse models of Alzheimer's disease | We previously demonstrated that ibrutinib modulates LPS-induced neuroinflammation in vitro and in vivo, but its effects on the pathology of Alzheimer's disease (AD) and cognitive function have not been investigated. Here, we investigated the effects of ibrutinib in two mouse models of AD. In 5xFAD mice, ibrutinib injection significantly reduced A beta plaque levels by promoting the non-amyloidogenic pathway of APP cleavage, decreased A beta-induced neuroinflammatory responses, and significantly downregulated phosphorylation of tau by reducing levels of phosphorylated cyclin-dependent kinase-5 (p-CDK5). Importantly, tau-mediated neuroinflammation and tau phosphorylation were also alleviated by ibrutinib injection in PS19 mice. In 5xFAD mice, ibrutinib improved long-term memory and dendritic spine number, whereas in PS19 mice, ibrutinib did not alter short- and long-term memory but promoted dendritic spinogenesis. Interestingly, the induction of dendritic spinogenesis by ibrutinib was dependent on the phosphorylation of phosphoinositide 3-kinase (PI3K). Overall, our results suggest that ibrutinib modulates AD-associated pathology and cognitive function and may be a potential therapy for AD. | Lee, Hyun-ju; Jeon, Seong Gak; Kim, Jieun; Kang, Ri Jin; Kim, Seong-Min; Han, Kyung-Min; Park, HyunHee; Kim, Ki-taek; Sung, You Me; Nam, Hye Yeon; Koh, Young Ho; Song, Minseok; Suk, Kyoungho; Hoe, Hyang-Sook | Korea Brain Res Inst KBRI, Dept Neural Dev & Dis, 61 Cheomdan Ro, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, Med Device Dev Ctr, Daegu, South Korea; Yeungnam Univ, Dept Life Sci, Gyongsan, South Korea; Seoul Natl Univ, Korea Mouse Phenotyping Ctr KMPC, Seoul, South Korea; Korea Natl Inst Hlth, Div Brain Dis, Ctr Infect Dis, Ctr Biomed Sci, Cheongwon, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Pharmacol, Daegu, South Korea; Daegu Gyeongbuk Inst Sci Technol, Dept Brain & Cognit Sci, Daegu, South Korea | 57210856291; 57191415116; 59088374500; 57211491762; 57985342900; 57211004682; 58833770300; 57222322473; 56384972800; 57203939657; 23497603200; 55959937400; 7005114595; 8948946800 | sookhoe72@kbri.re.kr; | AGING CELL | AGING CELL | 1474-9718 | 1474-9726 | 20 | 3 | SCIE | CELL BIOLOGY;GERIATRICS & GERONTOLOGY | 2021 | 11.005 | 6.5 | 2.75 | 2025-07-30 | 44 | 47 | 5xFAD mice; Alzheimer' s disease; amyloid beta; ibrutinib; neuroinflammation; PS19 mice; spinogenesis; tau | 5xFAD mice; Alzheimer's disease; amyloid beta; ibrutinib; neuroinflammation; PS19 mice; spinogenesis; tau | Adenine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Cyclin-Dependent Kinase 5; Cytokines; Dendritic Spines; Disease Models, Animal; Down-Regulation; Gliosis; Inflammation; Inflammation Mediators; Memory, Long-Term; Mice, Transgenic; Neurogenesis; Neuroglia; Phosphorylation; Piperidines; Plaque, Amyloid; tau Proteins; 2 morpholino 8 phenylchromone; amyloid beta protein; cyclin dependent kinase 5; cyclooxygenase 2; glial fibrillary acidic protein; ibrutinib; interleukin 1beta; interleukin 6; phosphatidylinositol 3 kinase; s 2680; spebrutinib; tau protein; adenine; amyloid beta protein; autacoid; cyclin dependent kinase 5; cytokine; ibrutinib; piperidine derivative; tau protein; Alzheimer disease; animal cell; animal experiment; animal model; animal tissue; Article; astrocytosis; blood brain barrier; brain cell; brain tissue; cognition; confocal laser scanning microscopy; controlled study; dendritic spine; diagnostic test; down regulation; drug megadose; embryo; gliosis; Golgi stain; high performance liquid chromatography; hippocampal CA1 region; hippocampus; histopathology; immunofluorescence test; immunohistochemistry; immunoreactivity; long term memory; male; mass spectrometry; mouse; nervous system inflammation; nonhuman; priority journal; protein phosphorylation; rat; Alzheimer disease; amyloid plaque; animal; brain; complication; disease model; drug effect; glia; inflammation; metabolism; nervous system development; pathology; pathophysiology; phosphorylation; transgenic mouse | English | 2021 | 2021-03 | 10.1111/acel.13332 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Licoricidin Abrogates T-Cell Activation by Modulating PTPN1 Activity and Attenuates Atopic Dermatitis In Vivo | Licoricidin, the fifth-highest fraction among the isolated 48 molecules from Glycyrrhiza uralensis extracts, has been known as an anti-inflammatory bioactive molecule; however, few studies have shown its inhibitory effect on T-cell activation and atopic dermatitis (AD). This study examined the therapeutic potential of licoricidin in AD by modulating T-cell activation with molecular mechanisms. Licoricidin attenuated the expression of IL-2 mRNA in stimulated T cells without cytotoxicity. Because tyrosine-protein phosphatase nonreceptor type 1 was predicted to interact physically with licoricidin in T cells in silico analysis, the results of tyrosine-protein phosphatase nonreceptor type 1 activity assay and phosphorylation study predicted that licoricidin might abrogate the activity of tyrosine-protein phosphatase nonreceptor type 1 during T-cell activation. Pretreatment with licoricidin controlled the dephosphorylation of Lck on TCR-mediated stimulation. Moreover, licoricidin alleviated the symptoms of dinitrochlorobenzene-and/or mite extract-induced AD, including ear thickness and serum IgE level. Microscopic analysis also showed the effects of licoricidin on the thickness of the dermis and epidermis and infiltration of immune cells. Furthermore, mRNA levels of proinflammatory cytokines were attenuated in the ear lesions of licoricidin-treated AD mice. Therefore, licoricidin has therapeutic potential for treating AD, and its underlying mechanism involves effective modulation of T-cell activation by controlling tyrosine-protein phosphatase nonreceptor type 1 to maintain Lck phosphorylation. | Lee, Hyun-Su; Kim, Jooyoung; Choi, Hyun Gyu; Kim, Eun-Kyung; Jun, Chang-Duk | Gwangju Inst Sci & Technol GIST, Sch Life Sci, Gwangju, South Korea; Gwangju Inst Sci & Technol GIST, Immune Synapse & Cell Therapy Res Ctr, Gwangju, South Korea; Konkuk Univ, Off Acad Affairs, Chungju, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu, South Korea; Dong A Univ, Dept Food Sci & Nutr, Coll Hlth Sci, Busan 49315, South Korea; Dong A Univ, Brain Busan Plus Program 21, Ctr Silver Targeted Biomat, Busan, South Korea | 57272028400; 55720240400; 57214846990; 57201655352; 7103018249 | ekkim@dau.ac.kr; | JOURNAL OF INVESTIGATIVE DERMATOLOGY | J INVEST DERMATOL | 0022-202X | 1523-1747 | 141 | 10 | SCIE | DERMATOLOGY | 2021 | 7.59 | 6.5 | 0.98 | 2025-07-30 | 12 | 15 | PROTEIN-TYROSINE-PHOSPHATASE; ALLERGIC CONTACT-DERMATITIS; PTP1B; PHOSPHORYLATION; RECEPTOR; CD45; IDENTIFICATION; GLYCYRRHIZIN; INHIBITION; FLAVONOIDS | Animals; Benzopyrans; Cytokines; Dermatitis, Atopic; Female; Humans; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; T-Lymphocytes; 1 chloro 2,4 dinitrobenzene; Glycyrrhiza uralensis extract; house dust mite allergen extract; immunoglobulin E; interleukin 2; licoricidin; messenger RNA; protein kinase Lck; protein tyrosine phosphatase 1B; unclassified drug; benzopyran derivative; cytokine; interleukin 2; licoricidin; protein tyrosine phosphatase 1B; PTPN1 protein, human; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; attenuation; cell infiltration; cell viability; cytokine production; cytotoxicity; dermis; drug effect; drug efficacy; drug isolation; drug mechanism; drug targeting; ear thickness; ear tissue; enzyme activity; enzyme assay; enzyme inhibition; enzyme phosphorylation; epidermis; female; histopathology; human; human cell; immunocompetent cell; immunoglobulin blood level; immunomodulation; in vivo study; microscopy; mouse; MTT assay; nonhuman; protein dephosphorylation; protein expression; T lymphocyte; T lymphocyte activation; Western blotting; animal; atopic dermatitis; Bagg albino mouse; biosynthesis; drug effect; genetics; immunology; Jurkat cell line; lymphocyte activation; metabolism | English | 2021 | 2021-10 | 10.1016/j.jid.2021.02.759 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Rotating Cylinder-Assisted Nanoimprint Lithography for Enhanced Chemisorbable Filtration Complemented by Molecularly Imprinted Polymers | Rotating cylindrical stamp-based nanoimprint technique has many advantages, including the continuous fabrication of intriguing micro/nanostructures and rapid pattern transfer on a large scale. Despite these advantages, the previous nanoimprint lithography has rarely been used for producing sophisticated nanoscale patterns on a non-planar substrate that has many extended applications. Here, the simple integration of nanoimprinting process with a help of a transparent stamp wrapped on the cylindrical roll and UV optical source in the core to enable high-throughput pattern transfer, particularly on a fabric substrate is demonstrated. Moreover, as a functional resin material, this innovative strategy involves a synergistic approach on the synthesis of molecularly imprinted polymer, which are spatially organized free-standing perforated nanostructures such as nano/microscale lines, posts, and holes patterns on various woven or nonwoven blank substrates. The proposed materials can serve as a self-encoded filtration medium for selective separation of formaldehyde molecules. It is envisioned that the combinatorial fabrication process and attractive material paves the way for designing next-generation separation systems in use to capture industrial or household toxic substances. | Jeon, Sangheon; Park, Rowoon; Jeong, Jeonghwa; Heo, Gyeonghwa; Lee, Jihye; Shin, Min Chan; Kwon, Young Woo; Yang, Jin Chul; Park, Woon Ik; Kim, Ki Su; Park, Jinyoung; Hong, Suck Won | Pusan Natl Univ, Dept Opt & Mechatron Engn, Dept Cogno Mechatron Engn, Coll Nanosci & Nanotechnol, Busan 46241, South Korea; Pusan Natl Univ, Dept Nanofus Engn, Coll Nanosci & Nanotechnol, Busan 46241, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, Daegu 41566, South Korea; Pukyong Natl Univ, Coll Engn, Dept Mat Sci & Engn, Busan 48547, South Korea; Pusan Natl Univ, Coll Engn, Dept Organ Mat Sci & Engn, Busan 46241, South Korea | ; Shin, Min/AAU-6206-2021; PARK, JUN-YOUNG/P-5981-2015 | 57202416639; 57202423243; 57197117040; 57359021300; 55689992200; 57218903537; 57208480223; 56381794400; 53980463200; 7409322172; 57286293400; 57252820400 | jinpark@knu.ac.kr;swhong@pusan.ac.kr; | SMALL | SMALL | 1613-6810 | 1613-6829 | 17 | 52 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2021 | 15.153 | 6.5 | 0.52 | 2025-07-30 | 11 | 9 | chemical filtration; molecularly imprinted polymers; nanoimprint lithography; roll-to-plate | ROLL-TO-ROLL; SCALABLE FABRICATION; NANOSTRUCTURES | Molecularly Imprinted Polymers; Nanostructures; Printing; Substrates; Weaving; molecularly imprinted polymer; nanomaterial; Chemical filtration; Large-scales; Micronanostructure; Molecularly Imprinted Polymer; Nano-scale patterns; Nanoimprint techniques; Non-planar substrates; Pattern transfers; Roll-to-plate; Rotating cylinders; printing; Nanoimprint lithography | English | 2021 | 2021-12 | 10.1002/smll.202105733 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Detection of infectious white spot syndrome virus in red claw crayfish (Cherax quadricarinatus) and red swamp crayfish (Procambarus clarkii) imported into Korea | White spot syndrome virus (WSSV) is one of the most virulent viruses in crustaceans, causing severe economic losses to aquaculture industry. In this study, we tested for the presence of WSSV in the commodity crayfish imported to Korea and also examined the potential infectivity of WSSV in the commodity WSSV-positive crayfish. For the sampling, two species of crayfish, Cherax quadricarinatus (320 red claw crayfish in eight batches) imported from Indonesia and Procambarus clarkii (40 red swamp crayfish in two batches) imported from China, were obtained from fishery markets in Korea. Five representative samples per batch (N = 50) were screened for WSSV using PCR assay, and the virus was detected in five C. quadricarinatus samples and one P. clarkii sample. Among the WSSV-positive samples, the highest virus titer (the copies ranged between 4.93 x 10(5) and 8.36 x 10(6) copies/mu L) was detected in the P. clarkii sample (20 012) by qPCR, and a comparatively low titer was observed in the C. quadricarinatus sample (20-008) (the copies ranged between 5.94 x 10(1) and 3.86 x 10(5) copies/mu L). Following the virus infectivity test, WSSV infection was confirmed after feeding WSSV-positive crayfish tissue (20-008, 3.46 x 10(7) WSSV copies/mu L) to Penaeus vannamei (Pacific white shrimp, N = 42) at 5% shrimp biomass. This is the first report of confirmed infectivity of WSSV from the commodity crayfish imported into Korea, suggesting that virus-infected frozen crayfish may present a potential source of viral disease in Korean shrimp aquaculture. Therefore, accurate and strict monitoring of crustacean viruses is required for imported crayfish from foreign countries into Korea. | Lee, Chorong; Kim, Ji Hyung; Choi, Seong-Kyoon; Jeon, Hye Jin; Lee, Seung Ho; Kim, Bum Keun; Kim, Young Kyun; Lee, Kyeong-Jun; Han, Jee Eun | Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon 34141, South Korea; DGIST, Core Prot Resources Ctr, Daegu 42988, South Korea; DGIST, Div Biotechnol, Daegu 42988, South Korea; Jeju Natl Univ, Dept Marine Life Sci, Jeju 63243, South Korea | ; Kim, Ji Hyung/B-7321-2011 | 56707749200; 57225000204; 55505432500; 57212193058; 57216443506; 57225056167; 57225051115; 8710985300; 57214671240 | kjlee@jejunu.ac.kr;jehan@knu.ac.kr; | AQUACULTURE | AQUACULTURE | 0044-8486 | 1873-5622 | 544 | SCIE | FISHERIES;MARINE & FRESHWATER BIOLOGY | 2021 | 5.135 | 6.6 | 1.21 | 2025-07-30 | 13 | 14 | Crustacean viruses; Penaeus vannamei; Bioassay; Aquaculture; Monitoring | LITOPENAEUS-VANNAMEI; WSSV INFECTION; PENAEID SHRIMP; VIRAL DISEASE; TIGER SHRIMP; TRANSMISSION; MOVEMENT; CRABS | Aquaculture; Bioassay; Crustacean viruses; Monitoring; Penaeus vannamei | China; Indonesia; Korea; Astacoidea; Cherax quadricarinatus; Crustacea; Decapoda (Crustacea); Litopenaeus vannamei; Procambarus clarkii; Shrimp white spot syndrome virus; aquaculture; crayfish; infectious disease; shrimp culture; viral disease; virus | English | 2021 | 2021-11-15 | 10.1016/j.aquaculture.2021.737117 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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