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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Article | Establishing a Core Outcome Set for Peritoneal Dialysis: Report of the SONG-PD (Standardized Outcomes in Nephrology-Peritoneal Dialysis) Consensus Workshop | Outcomes reported in randomized controlled trials in peritoneal dialysis (PD) are diverse, are measured inconsistently, and may not be important to patients, families, and clinicians. The Standardized Outcomes in Nephrology-Peritoneal Dialysis (SONG-PD) initiative aims to establish a core outcome set for trials in PD based on the shared priorities of all stakeholders. We convened an international SONG-PD stakeholder consensus workshop in May 2018 in Vancouver, Canada. Nineteen patients/caregivers and 51 health professionals attended. Participants discussed core outcome domains and implementation in trials in PD. Four themes relating to the formation of core outcome domains were identified: life participation as a main goal of PD, impact of fatigue, empowerment for preparation and planning, and separation of contributing factors from core factors. Considerations for implementation were identified: standardizing patient-reported outcomes, requiring a validated and feasible measure, simplicity of binary outcomes, responsiveness to interventions, and using positive terminology. All stakeholders supported inclusion of PD-related infection, cardiovascular disease, mortality, technique survival, and life participation as the core outcome domains for PD. | Manera, Karine E.; Johnson, David W.; Craig, Jonathan C.; Shen, Jenny I.; Gutman, Talia; Cho, Yeoungjee; Wang, Angela Yee-Moon; Brown, Edwina A.; Brunier, Gillian; Dong, Jie; Dunning, Tony; Mehrotra, Rajnish; Naicker, Saraladevi; Pecoits-Filho, Roberto; Perl, Jeffrey; Wilkie, Martin; Tong, Allison; Levin, Adeera; Liew, Adrian; Cueto Manzano, Alfonso; Abu Alfa, Ali; Neu, Alicia; Baumgartf, Amanda; Bernier-Jean, Amelie; Kelly, Amy; Figueiredo, Ana; Matus, Andrea; Viecelli, Andrea; Ju, Angela; Saxena, Anjali; Sharma, Ankit; Nadeau-Fredette, Annie-Claire; Teixeira-Pinto, Armando; Mendelson, Asher; Kelly, Ayano; Goh, Bak Leong; Sautenet, Benedicte; Manns, Braden; Hemmelgarn, Brenda; Robinson, Bruce; Hanson, Camilla; Cheung, Catherine; Guha, Chandana; Logeman, Charlotte; Szeto, Cheuk-Chun; Rutherford, Claudia; Schwartz, Daniel; Sumpton, Daniel; Johnson, David; Wheeler, David; Brown, Edwina; O'Lone, Emma; Au, Eric; Goffin, Eric; Finkelstein, Fred; Abraham, Georgi; Brunier, Gillian; Germino, Greg; Hurst, Helen; Kawanishi, Hideki; Htay, Htay; Yap, Hui Kim; Teitelbaum, Isaac; Perl, Jeffrey; Chen, Jenny; Shen, Jenny; Dong, Jie; Neumann, Joanna; Bargman, Joanne; Morelle, Johann; Craig, Jonathan; Kilonzo, Kajiru Gad; Yeates, Karen; Maner, Karine; Azukaitis, Karolis; Van, Kim Linh; Dunn, Louese; Krishnan, Mahesh; Lambie, Mark; Howell, Martin; Schreiber, Martin; Wilkie, Martin; Oliver, Matthew; Sanabria, Mauricio Rafael; Nataatmadja, Melissa; Lichodziejewska-Niemierko, Monika; Verdin, Nancy; Mann, Neelam; Boudville, Neil; Evangelidis, Nicole; Scholes-Robertson, Nicole; Blake, Peter; Nourse, Peter; Tugwell, Peter; Li, Philip Kam-Tao; Mehrotra, Rajnish; McGee, Richard; Quinn, Robert; Crowe, Sally; Anumudu, Samaya; Bernays, Sarah; Naicker, Sarala; Wilson, Scott; Nessim, Sharon; Teo, Sharon; Carter, Simon A.; Davies, Simon; Sweety, Soheli Ahmed; Gutman, Talia; Toffelmire, Ted; Jassal, Vanita; Jha, Vivekanand; da Silva, Viviane Calice; Van Biesen, Wim; Winkelmayer, Wolfgang; Ito, Yasuhiko; Cho, Yeoungjee; Kim, Yong-Lim; Butt, Zeeshan | Univ British Columbia, Vancouver, BC, Canada; Tan Tock Seng Hosp, Singapore, Singapore; Salvador Zubir Natl Inst Hlth Sci & Nutr, Mexico City, DF, Mexico; Amer Univ Beirut, Beirut, Lebanon; Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA; Univ Sydney, Sydney, NSW, Australia; Pontificia Univ Catolica Rio Grande do Sul, Porto Alegre, RS, Brazil; Childrens Hosp Westmead, Westmead, NSW, Australia; Univ Queensland, Brisbane, Qld, Australia; Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China; Stanford Univ, Stanford, CA 94305 USA; Hop Maison Neuve Rosemont, Montreal, PQ, Canada; Western Univ, London, ON, Canada; Australian Natl Univ, Canberra, ACT, Australia; Serdang Hosp, Kajang, Selangor, Malaysia; Univ Tours, Tours, France; Univ Calgary, Calgary, AB, Canada; Arbor Res Collaborat Hlth, Mountain View, CA USA; Fraser Hlth Author, Vancouver, BC, Canada; Chinese Univ Hong Kong, Hong Kong, Peoples R China; UCL, London, England; Imperial Coll London, London, England; Catholic Univ Louvain, Louvain La Neuve, Belgium; Bridgeport Hosp, Bridgeport, CT USA; Pondycherry Inst Med Sci, Pondicherry, India; Sunnybrook Res Inst, Toronto, ON, Canada; NIDDK, Bethesda, MD 20892 USA; Manchester Univ Fdn Trust, Manchester, Lancs, England; Tsuchiya Gen Hosp, Hiroshima, Japan; Singapore Gen Hosp, Singapore, Singapore; Natl Univ Singapore, Singapore, Singapore; Univ Colorado Hosp, Aurora, CO USA; Univ Toronto, Toronto, ON, Canada; Prince Wales Hosp, Hong Kong, Peoples R China; Univ Calif Los Angeles, Los Angeles, CA USA; Peking Univ, Beijing, Peoples R China; Satellite Healthcare, San Jose, CA USA; Clin Univ St Luc, Brussels, Belgium; Flinders Univ S Australia, Adelaide, SA, Australia; Kilimanjaro Christian Med Ctr, Moshi, Tanzania; Queens Univ, Kingston, ON, Canada; Kingston Hlth Sci Ctr, Kingston, ON, Canada; Vilnius Univ, Vilnius, Lithuania; Univ Sheffield, Sheffield, S Yorkshire, England; DaVita, Denver, CO USA; Keele Univ, Keele, Staffs, England; NHS Sheffield Teaching Hosp, Sheffield, S Yorkshire, England; Univ Los Andes, Bogota, Colombia; Med Univ Gdansk, Gdansk, Poland; Alberta Hlth Serv, Edmonton, AB, Canada; Univ Western Australia, Nedlands, WA, Australia; Red Cross War Mem Childrens Hosp, Cape Town, South Africa; Univ Ottawa, Ottawa, ON, Canada; Univ Washington, Seattle, WA 98195 USA; Pontificia Univ Catolica Parana, Curitiba, Parana, Brazil; Crowe Associates Ltd, Thame, England; Baylor Coll Med, Houston, TX 77030 USA; Univ Witwatersrand, Johannesburg, South Africa; Monash Univ, Clayton, Vic, Australia; McGill Univ, Montreal, PQ, Canada; Univ Hosp North Midlands, Stoke On Trent, Staffs, England; Dhaka Med Coll Hosp, Dhaka, Bangladesh; Fresenius Med Care, Bad Homburg, Germany; George Inst Global Hlth, Sydney, NSW, Australia; Univ Catolica Pelotas, Pelotas, RS, Brazil; Univ Ghent, Ghent, Belgium; Nagoya Univ, Nagoya, Aichi, Japan; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Northwestern Univ, Evanston, IL 60208 USA; Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia; Childrens Hosp Westmead, Ctr Kidney Res, Sydney, NSW 2145, Australia; Princess Alexandra Hosp, Dept Nephrol, Harlow, Essex, England; Univ Queensland, Australasian Kidney Trials Network, Sch Med, Brisbane, Qld, Australia; Translat Res Inst, Woolloongabba, Qld, Australia; Univ Queensland, Princess Alexandra Hosp, Ctr Kidney Dis Res, Brisbane, Qld, Australia; Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA, Australia; Harbor UCLA Med Ctr, Div Nephrol & Hypertens, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA; Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China; Hammersmith Hosp, Imperial Coll Renal & Transplant Ctr, London, England; Peking Univ, Div Renal, Dept Med, Hosp 1, Beijing, Peoples R China; South Bank TAFE, Brisbane, Qld, Australia; Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA; Univ Washington, Harborview Med Ctr, Div Nephrol, Dept Med, Seattle, WA 98195 USA; Univ Witwatersrand, Fac Hlth Sci, Dept Internal Med, Sch Clin Med, Johannesburg, South Africa; Pontificia Univ Catolica Parana, Sch Med, Curitiba, Parana, Brazil; Arbor Res Collaborat Hlth, Ann Arbor, MI USA; Univ Toronto, St Michaels Hosp, Div Nephrol, Dept Med, Toronto, ON, Canada; Sheffield Teaching Hosp NHS Fdn Trust, Dept Nephrol, Sheffield, S Yorkshire, England | ; Johnson, David/F-2897-2011; Scholes-Robertson, Nicole/KQU-4216-2024; Figueiredo, Ana/C-2137-2013; Morelle, Johann/JXM-1687-2024; Manns, Braden/I-8942-2012; Au, Eric/I-9582-2019; Tugwell, Peter/AFD-8076-2022; Figueiredo, Ana Elizabeth/C-2137-2013; Szeto, Cheuk/N-4954-2015; Jha, Vivek kumar/AHC-6454-2022; Teo, Sharon/GSM-8060-2022; Lambie, Mark/AAA-9104-2020; Wang, Angela/B-9944-2008; Viecelli, Andrea/G-6966-2017; Craig, Jonathan/E-2813-2013; McGee, Richard/C-6117-2009; Kim, Yong-Lim/AGK-3172-2022; Brunier, Gillian/ABD-2878-2020; Wheeler, David/AGH-5097-2022; Li, Philip/D-4051-2017; Scholes-Robertson, Nicole/ABB-9461-2021; Manera, Karine/ABH-9074-2020; Martin, Schreiber/F-2175-2013; Kelly, Ayano/ABE-6800-2020; Yap, Hui/S-2934-2016; Dong, Jie/AFM-0048-2022; Quinn, Robert/E-7017-2011; Htay, Htay/AAU-8471-2021; Mehrotra, Rajnish/IUN-6202-2023; Hemmelgarn, Brenda/IYS-7463-2023; Boudville, Neil/H-8864-2014; Perl, Jeffrey/HKW-4066-2023; Bernays, Sarah/AFT-0369-2022; Azukaitis, Karolis/AAQ-8103-2021; Shen, Jenny/JYF-5277-2024; Sautenet, Benedicte/JTU-5150-2023; Cho, Yeoungjee/G-6176-2013; Nourse, Peter/AAR-8284-2021; Teixeira-Pinto, Armando/H-7947-2013 | karine.manera@sydney.edu.au; | AMERICAN JOURNAL OF KIDNEY DISEASES | AM J KIDNEY DIS | 0272-6386 | 1523-6838 | 75 | 3 | SCIE | UROLOGY & NEPHROLOGY | 2020 | 8.86 | 7.3 | 133 | CLINICAL-TRIALS; THEMATIC SYNTHESIS | English | 2020 | 2020-03 | 10.1053/j.ajkd.2019.09.017 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Gd-Complex of a Rosmarinic Acid Conjugate as an Anti-Inflammatory Theranostic Agent via Reactive Oxygen Species Scavenging | Rosmarinic acid (RosA), an important polyphenol, is known for its antioxidant and anti-inflammatory activities. However, its application in theranostics has been rarely reported. Therefore, a new single-molecule anti-inflammatory theranostic compound containing RosA would be of great interest. A gadolinium (Gd) complex of 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) and RosA (Gd(DO3A-RosA)(H2O)) was synthesized and examined for use as a single-molecule theranostic agent. Its kinetic stability is comparable to that of clinically used macrocyclic magnetic resonance imaging contrast agents. In addition, its relaxivity is higher than that of structurally analogous Gd-BT-DO3A. This agent was evaluated for inflammatory targeting magnetic resonance contrast and showed strong and prolonged enhancement of imaging in inflamed tissues of mice. The theranostic agent also possesses antioxidant and anti-inflammatory activities, as evidenced by reactive oxygen species scavenging, superoxide dismutase activity, and inflammatory factors. The novel RosA-conjugated Gd complex is a promising theranostic agent for the imaging of inflamed tissues, as well as for the treatment of inflammation and oxidative stress. | Kim, Hee-Kyung; Hwang, Seonghwan; Sung, Bokyung; Kim, Yeoun-Hee; Chang, Yongmin | Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41944, South Korea; Mirae BioPharm Co, 124 Sagimakgol Ro, Gyeonggi Do, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Mol Med, Sch Med, Daegu 41944, South Korea | 56014729400; 57218566487; 58929528400; 57576538700; 7501840633 | hkkim@dgmif.re.kr;tjdghks4277@naver.com;xxgzxz4@naver.com;bigeye38@naver.com;ychang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 0.59 | 2025-06-25 | 12 | 11 | rosmarinic acid; Gd-chelate; anti-inflammatory effects; antioxidants; theranostic agent | OXIDATIVE STRESS; OFFICINALIS L.; ANTIOXIDANTS; INFLAMMATION; LIVER; EXTRACT; DERIVATIVES; TOXICITY; DISEASES; DAMAGE | Anti-inflammatory effects; Antioxidants; Gd-chelate; Rosmarinic acid; Theranostic agent | English | 2020 | 2020-08 | 10.3390/antiox9080744 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article; Proceedings Paper | High density tungsten gadolinium borate glasses doped with Eu³⁺ ion for photonic and scintillator applications | The melt quenching technique used to prepare tungsten gadolinium borate (Eu: WGdB) glasses doped with different concentrations of Eu3+ ions. The structural and spectroscopic analysis have been carried out by density, molar volume, X-ray absorption spectroscopy (XAS), UV-VIS-NIR absorption, excitation, emission spectra and decay time measurements. The glasses containing WO3 exhibit a high density of more than 6.00 g/cm(3) and performs the enhanced compaction with increment of Eu2O3 content. The average coordination number of oxygen surrounding Eu3+ is 6.000 and the average bond length between Eu3+ and oxygen is 2.3740 angstrom. Eu3+ in glass absorb photons in visible light and near infrared region. The strong reddish orange emission around 613 nm via D-5(0)-> F-7(2) radiation transition of Eu3+ was generated under different types of excitation such as ultraviolet, visible light and X-ray. The Gd3+ - Eu3+ energy transfer has an important role for strong reddish orange emission under 275 nm excitation. The Judd-Ofelt (J-O) theory was used to predict the radiative properties for the Eu3+ ion emission levels. The decay curves of the D-5(0) levels exhibit single exponential nature with a lifetime of millisecond order. The high stimulated emission cross-section and intense emission with 613 nm wavelength suggests that the present Eu-WGdB glasses could be useful for the solid-state laser, display devices and radiation detecting material applications. | Wantana, N.; Kaewnuam, E.; Ruangtaweep, Y.; Kidkhunthod, P.; Kim, H. J.; Kothan, S.; Kaewkhao, J. | Nakhon Pathom Rajabhat Univ, Fac Sci & Technol, Phys Program, Nakhon Pathom 73000, Thailand; Nakhon Pathom Rajabhat Univ, Ctr Excellence Glass Technol & Mat Sci CEGM, Nakhon Pathom 73000, Thailand; Muban Chombueng Rajabhat Univ, Fac Sci & Technol, Phys Program, Ratchaburi 70150, Thailand; Publ Org, Synchrotron Light Res Inst, 111 Univ Ave, Nakhon Ratchasima 30000, Thailand; Kyungpook Natl Univ, Dept Phys, Taegu 702701, South Korea; Chiang Mai Univ, Fac Associated Med Sci, Ctr Radiat Res & Med Imaging Dept Radiol Technol, Chiang Mai 50200, Thailand | ; Kim, Hong Joo/AAE-1178-2022; Kaewnaum, Eakgapon/JWO-6262-2024 | 56267058700; 56267295300; 37108588700; 35272197100; 59051568100; 6507017165; 23974520300 | w.nuanthip@gmail.com;jakrapong@webmail.npru.ac.th; | RADIATION PHYSICS AND CHEMISTRY | RADIAT PHYS CHEM | 0969-806X | 172 | SCIE | CHEMISTRY, PHYSICAL;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.858 | 7.3 | 6.68 | 2025-06-25 | 67 | 72 | Tungsten; Europium; High density glass; X-ray absorption | SPECTROSCOPIC PROPERTIES; LUMINESCENT PROPERTIES; LITHIUM BORATE; LASER MEDIUM; PROPERTY; BEHAVIOR; GD3+; SM3+ | Europium; High density glass; Tungsten; X-ray absorption | Bond length; Citrus fruits; Display devices; Emission spectroscopy; Energy transfer; Europium; Europium compounds; Gadolinium compounds; Glass; Infrared devices; Ions; Judd-Ofelt theory; Light; Oxygen; Solid state lasers; Spectroscopic analysis; Tungsten; Tungsten compounds; X ray absorption; X ray absorption spectroscopy; chemical compound; europium; tungsten gadolinium borate; unclassified drug; Average coordination number; High density glass; Material application; Melt quenching techniques; Radiation transitions; Stimulated emission cross section; Structural and spectroscopic analysis; UV-Vis-NIR absorption; Article; concentration (parameter); energy transfer; excitation; Fourier transform infrared spectroscopy; photoluminescence; quantum yield; structure analysis; ultraviolet visible spectrophotometry; X ray absorption spectroscopy; X ray diffraction; Boron compounds | English | 2020 | 2020-07 | 10.1016/j.radphyschem.2020.108868 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of transcriptional responsive genes to acetic acid, ethanol, and 2-phenylethanol exposure in Drosophila melanogaster | The fruit fly, Drosophila melanogaster, is predominantly found in overripe, rotten, fermenting, or decaying fruits and is constantly exposed to chemical stressors such as acetic acid, ethanol, and 2-phenylethanol. D. melanogaster has been employed as a model system for studying the molecular bases of various types of chemical-induced tolerance. Expression profiling using Illumina sequencing has been performed for identifying changes in gene expression that may be associated with evolutionary adaptation to exposure of acetic acid, ethanol, and 2-phenylethanol. We identified a total of 457 differentially expressed genes that may affect sensitivity or tolerance to three chemicals in the chemical treatment group as opposed to the control group. Gene-set enrichment analysis revealed that the genes involved in metabolism, multicellular organism reproduction, olfaction, regulation of signal transduction, and stress tolerance were over-represented in response to chemical exposure. Furthermore, we also detected a coordinated upregulation of genes in the Toll- and Imd-signaling pathways after the chemical exposure. Quantitative reverse transcription PCR analysis revealed that the expression levels of nine genes within the set of genes identified by RNA sequencing were up- or downregulated owing to chemical exposure. Taken together, our data suggest that such differentially expressed genes are coordinately affected by chemical exposure. Transcriptional analyses after exposure of D. melanogaster with three chemicals provide unique insights into subsequent functional studies on the mechanisms underlying the evolutionary adaptation of insect species to environmental chemical stressors. | Seong, Keon Mook; Kim, YeongHo; Kim, Donghun; Pittendrigh, Barry R.; Kim, Young Ho | Michigan State Univ, Dept Entomol, E Lansing, MI 48824 USA; Kyungpook Natl Univ, Dept Ecol Sci, Sangju, Gyeongbuk, South Korea | Kim, Young/J-5414-2012 | 26635871000; 57204608118; 56115927500; 7004045385; 58516491300 | yhkim05@knu.ac.kr; | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | PESTIC BIOCHEM PHYS | 0048-3575 | 1095-9939 | 165 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2020 | 3.963 | 7.3 | 0.4 | 2025-06-25 | 7 | 6 | Fruit fly; Acetic acid; Ethanol; 2-phenylethanol; Transcriptome; Adaptation | EVOLUTIONARY ECOLOGY; OXIDATIVE STRESS; IMMUNE-RESPONSE; TOLERANCE; HOST; PREFERENCE; PLANT; CYTOCHROME-P450; SENSITIVITY; ATTRACTION | 2-phenylethanol; Acetic acid; Adaptation; Ethanol; Fruit fly; Transcriptome | Acetic Acid; Animals; Drosophila; Drosophila melanogaster; Ethanol; Gene Expression Profiling; Phenylethyl Alcohol; acetic acid; alcohol; phenethyl alcohol; animal; Drosophila; Drosophila melanogaster; gene expression profiling | English | 2020 | 2020-05 | 10.1016/j.pestbp.2020.02.018 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Irradiation effects on chemical and functional qualities of ready-to-eat Saengshik, a cereal health food | Saengshik is an uncooked Korean meal comprising of more than thirty different ingredients of plant and animal origins. In Korea, to reduce the microbial loads in the product, electron-beam (EB) or gamma-ray (GR) irradiation at 5 kGy is permitted for its major cereal ingredients. But decontamination effects are not often satisfied. Considering the over-doses in commercial treatment, this study intended to investigate EB and GR irradiations up to 10 kGy on the physicochemical and functional qualities of prepackaged Saengshik. The reducing sugar and amino nitrogen were not significantly affected, whereas total chlorophylls, carotenoids, phenolics, and antioxidant activities were more sensitive to both types of irradiation. Total carotenoids and chlorophylls were reduced at high irradiation doses. In contrast, irradiation increased the free radical scavenging abilities that may be due to increase in total phenolic content (139.63-169.02 mg/100 g, EB; 139.63-168.56 mg/100 g, GR). Although there was slight decrease in the chlorophyll and carotenoid constituents of Saengshik, irradiation up to 10 kGy improved its antioxidant activity without affecting the reducing sugar and amino nitrogen. Dose escalation up to 10 kGy for the cereal product revealed stable reducing sugar and amino nitrogen contents with slight changes below 0.31% in total chlorophylls, carotenoids, phenolics, and antioxidant properties. | Kim, Gui-Ran; Ramakrishnan, Sudha Rani; Ameer, Kashif; Chung, Namhyeok; Kim, Yu-Ri; Kwon, Joong-Ho | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; PMAS Arid Agr Univ, Inst Food & Nutr Sci, Rawalpindi 46300, Pakistan; EBTECH Co Ltd, Daejeon, South Korea | ; Ameer, Kashif/H-5449-2019; Kim, Kwangsu/KLZ-5696-2024; Ramakrishnan, Sudha/V-6342-2017 | 36990890900; 57190606907; 57190066397; 56533286200; 12806382200; 36814712700 | jhkwon@knu.ac.kr; | RADIATION PHYSICS AND CHEMISTRY | RADIAT PHYS CHEM | 0969-806X | 1879-0895 | 171 | SCIE | CHEMISTRY, PHYSICAL;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.858 | 7.3 | 0.88 | 2025-06-25 | 8 | 12 | Functional quality; Irradiation; Physicochemical; Saengshik | ELECTRON-BEAM IRRADIATION; GAMMA-IRRADIATION; ANTIOXIDANT ACTIVITY; STORAGE; RADIATION; APOPTOSIS; SPROUTS | Functional quality; Irradiation; Physicochemical; Saengshik | Antioxidants; Cereal products; Chlorophyll; Free radicals; Gamma rays; Nitrogen; Pigments; Plants (botany); carotenoid; chlorophyll; nitrogen; phenol derivative; sugar; Anti-oxidant activities; Antioxidant properties; Decontamination effects; Free radical scavenging; Irradiation effect; Physicochemical; Saengshik; Total phenolic content; antioxidant activity; Article; cereal; chlorophyll content; controlled study; convenience food; electron radiation; food analysis; food contamination; food irradiation; free radical scavenging assay; gamma radiation; health food; organoleptic property; pathogen load; physical chemistry; radiation response; saengshik; Irradiation | English | 2020 | 2020-06 | 10.1016/j.radphyschem.2020.108692 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Light-Controlled Fruit Pigmentation and Flavor Volatiles in Tomato and Bell Pepper | Light is a major environmental factor affecting the regulation of secondary metabolites, such as pigments and flavor. The Solanaceae plant family has diverse patterns of fruit metabolisms that serve as suitable models to understand the molecular basis of its regulation across species. To investigate light-dependent regulation for fruit pigmentation and volatile flavors, major fruit pigments, their biosynthetic gene expression, and volatiles were analyzed in covered fruits of tomato and bell pepper. Immature covered fruits were found to be ivory in color and no chlorophyll was detected in both plants. The total carotenoid content was found to be reduced in ripe tomato and bell pepper under cover. Naringenin chalcone decreased more than 7-fold in ripe tomato and total flavonoids decreased about 10-fold in immature and ripe pepper fruit under light deficiency. Light positively impacts fruit pigmentation in tomato and bell pepper by regulating gene expression in carotenoid and flavonoid biosynthesis, especially phytoene synthase and chalcone synthase, respectively. Nineteen volatile flavors were detected, and seven of these exhibited light-dependent regulations for both ripe tomato and pepper. This study will help in improving fruit quality and aid future research works to understand the molecular mechanisms regulating the influence of light-dependency on pigments and flavor volatiles. | Yoo, Hee Ju; Kim, Jin-Hyun; Park, Kyoung-Sub; Son, Jung Eek; Lee, Je Min | Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; RDA, Natl Inst Hort & Herbal Sci, Protected Hort Res Inst, Haman 52054, South Korea; Mokpo Natl Univ, Dept Hort Sci, Muan 58554, South Korea; Seoul Natl Univ, Dept Plant Sci, Seoul 08826, South Korea | Lee, Je Min/F-9797-2014; Lee, Je/AAE-7496-2020 | 56103898300; 57553103800; 50262809900; 57202880960; 8885729900 | yhj901003@knu.ac.kr;weatherboy@korea.kr;unicos75@mokpo.ac.kr;sjeenv@snu.ac.kr;jemin@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 1.26 | 2025-06-25 | 19 | 22 | tomato; pepper; fruit ripening; light; carotenoid; flavonoid; flavor volatile | CAROTENOID BIOSYNTHESIS; CAPSICUM-ANNUUM; NUTRIENT CONTENT; ACCUMULATION; METABOLISM; QUALITY; BIOCHEMISTRY; TEMPERATURE; VALIDATION; MUTATION | Carotenoid; Flavonoid; Flavor volatile; Fruit ripening; Light; Pepper; Tomato | English | 2020 | 2020-01 | 10.3390/antiox9010014 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1 | Maslinic acid (MA), a natural compound of the triterpenoid group derived from olive, prevents the generation of pro-inflammatory cytokines and oxidative stress. In human umbilical vein endothelial cells (HUVECs) treated with lipopolysaccharide (LPS), we characterized the effects of MA on the regulation of heme oxygenase (HO)-1, cyclooxygenase (COX-)2, and inducible nitric oxide synthase (iNOS). MA was tested in the lung tissues of LPS-treated mice, to determine its effect on levels of iNOS expression and representative inflammatory mediators such as interleukin (IL)-1 alpha and tumor necrosis factor (TNF)-alpha. We show that MA induced the expression of HO-1, reduced LPS-induced NF-kappa B-luciferase activity, and inhibited iNOS/NO and COX-2/PGE2, resulting in the downregulation of STAT-1 phosphorylation. Furthermore, our data show that MA induced the nuclear translocation of Nrf2, increased the binding of Nrf2 to ARE, and decreased IL-1 alpha production in LPS-treated HUVECs. The MA-induced reduction in iNOS/NO expression was reversed by RNAi suppression of HO-1. In mice treated with LPS, MA significantly downregulated levels of iNOS in lung tissue and TNF-alpha in the bronchoalveolar lavage fluid. Taken together, our findings indicate that MA exerts a critical anti-inflammatory effect by modulating iNOS via the downregulation of NF-kappa B and p-STAT-1. Thus, we propose that MA may be an ideal substance to treat inflammatory diseases. | Lee, Wonhwa; Kim, Jaehong; Park, Eui Kyun; Bae, Jong-Sup | Kyungpook Natl Univ, BK21 Plus KNU Multiom Based Creat Drug Res Team, Res Inst Pharmaceut Sci, Coll Pharm,CMRI, Daegu 41566, South Korea; KRIBB, Aging Res Ctr, Daejeon 34141, South Korea; Gachon Univ, Coll Med, Dept Biochem, Incheon 21999, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, Daegu 41940, South Korea | ; Kim, Jaehong/AAJ-2051-2020; Bae, Jong-Sup/AAU-9724-2020; Lee, Wonhwa/GLQ-6506-2022 | 50161632800; 55992306000; 37071072400; 16021543200 | bywonhwalee@gmail.com;geretics@gachon.ac.kr;epark@knu.ac.kr;baejs@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 2.45 | 2025-06-25 | 43 | 45 | maslinic acid; endothelium; iNOS; p-STAT-1 | NATURAL TRITERPENE; CARBON-MONOXIDE; OLEA-EUROPAEA; RELEASE; CELLS; COX-2; MODEL | Endothelium; INOS; Maslinic acid; P-STAT-1 | English | 2020 | 2020-02 | 10.3390/antiox9020106 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Measurement of yield ratios for the isomeric pair ¹³⁷m,gCe in the ¹⁴¹Pr(γ, x)¹³⁷m,gCe reactions with bremsstrahlung end-point energies of 50-, 60-, and 70-MeV | We have measured the yield ratio of the high spin state to the low spin state of the isomeric pair Ce-137m,Ce-g produced in the Pr-141(gamma,x)Ce-137m,Ce-g reaction. The experiments were performed by irradiating three praseodymium foils with bremsstrahlung end-point energies of 50-, 60-, and 70-MeV. The induced activities of the Ce-137m and Ce-137g were measured by means of gamma-ray spectroscopy. The gamma-ray interference and the contributions of other radioisotopes to the measured activity of both the Ce-137m and Ce-137g were investigated and corrected. The obtained results are compared with the theoretical predictions using the computer code TALYS 1.8. The present results for the Pr-141(gamma,x)Ce-137m,Ce-g reaction were determined for the first time. | Nguyen Van Do; Nguyen Thanh Luan; Nguyen Thi Xuan; Pham Duc Khue; Nguyen Thi Hien; Kim, Guinyun; Kim, Kwangsoo; Shin, Sung-Gyun; Kye, Yong-uk; Cho, Moo-Hyun | Duy Tan Univ, Inst Theoret & Appl Res, 1 Phung Chi Kien St, Hanoi 100000, Vietnam; Duy Tan Univ, Fac Nat Sci, Da Nang 550000, Vietnam; Vietnam Acad Sci & Technol, Inst Phys, 10 Dao Tan, Hanoi, Vietnam; Vietnam Acad Sci & Technol, Grad Sch Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam; VINATOM, Inst Nucl Sci & Technol, 179 Hoang Quoc Viet, Hanoi, Vietnam; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Div Adv Nucl Engn, Pohang 37673, South Korea | Thanh Duong, Nguyen/AGY-4248-2022; Nguyen, Ngoc/AAO-7237-2020 | 16748257500; 57210576969; 57901826000; 14063183900; 59638495100; 35313854400; 36137214700; 55770867100; 56020858600; 17136702900 | gnkim@knu.ac.kr; | RADIATION PHYSICS AND CHEMISTRY | RADIAT PHYS CHEM | 0969-806X | 176 | SCIE | CHEMISTRY, PHYSICAL;NUCLEAR SCIENCE & TECHNOLOGY;PHYSICS, ATOMIC, MOLECULAR & CHEMICAL | 2020 | 2.858 | 7.3 | 0.25 | 2025-06-25 | 2 | 2 | Isomeric yield ratio; Pr-141(gamma,x)Ce-137m,Ce-g reaction; Activation method; gamma-ray spectrometry; Interference corrections | CROSS-SECTION; NEUTRONS; ISOTOPES; PROTONS; GAMMA | <sup>141</sup>Pr(γ,x)<sup>137m,g</sup>Ce reaction; Activation method; Interference corrections; Isomeric yield ratio; γ-ray spectrometry | Gamma ray spectrometers; Point contacts; Spin dynamics; cerium; cerium 137; praseodymium; praseodymium 141; radioisotope; unclassified drug; Computer codes; End points; Gamma-ray spectroscopy; High spin state; Induced activity; Spin state; Yield ratios; Article; bremsstrahlung end point energy; chemical reaction; controlled study; electric potential; gamma spectrometry; prediction; radiation energy; radiation measurement; radioactivity; radiological parameters; software; Gamma rays | English | 2020 | 2020-11 | 10.1016/j.radphyschem.2020.109016 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Natural Antioxidant and Anti-Inflammatory Compounds in Foodstuff or Medicinal Herbs Inducing Heme Oxygenase-1 Expression | Heme oxygenase-1 (HO-1) is an inducible antioxidant enzyme that catalyzes heme group degradation. Decreased level of HO-1 is correlated with disease progression, and HO-1 induction suppresses development of metabolic and neurological disorders. Natural compounds with antioxidant activities have emerged as a rich source of HO-1 inducers with marginal toxicity. Here we discuss the therapeutic role of HO-1 in obesity, hypertension, atherosclerosis, Parkinson's disease and hepatic fibrosis, and present important signaling pathway components that lead to HO-1 expression. We provide an updated, comprehensive list of natural HO-1 inducers in foodstuff and medicinal herbs categorized by their chemical structures. Based on the continued research in HO-1 signaling pathways and rapid development of their natural inducers, HO-1 may serve as a preventive and therapeutic target for metabolic and neurological disorders. | Hahn, Dongyup; Shin, Seung Ho; Bae, Jong-Sup | Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci, Dept Food & Nutr, Jinju 52828, South Korea; Kyungpook Natl Univ, BK21 Plus KNU MultiOm Based Creat Drug Res Team, Res Inst Pharmaceut Sci, CMRI,Coll Pharm, Daegu 41566, South Korea | Bae, Jong-Sup/AAU-9724-2020 | 36554163400; 57202845718; 16021543200 | dohahn@knu.ac.kr;shshin@gnu.ac.kr;baejs@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 0.43 | 2025-06-25 | 23 | 26 | heme oxygenase-1; antioxidant; anti-inflammatory compound; foodstuff; medicinal herbs | NF-KAPPA-B; ACID PHENETHYL ESTER; SMOOTH-MUSCLE-CELLS; NECROSIS-FACTOR-ALPHA; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; VASCULAR ENDOTHELIAL-CELLS; PDGF-INDUCED PROLIFERATION; LPS-INDUCED INFLAMMATION; INDUCED OXIDATIVE STRESS; P38 MAPK/NRF2 PATHWAY | Anti-inflammatory compound; Antioxidant; Foodstuff; Heme oxygenase-1; Medicinal herbs | English | 2020 | 2020-12 | 10.3390/antiox9121191 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Natural Nrf2 Modulators for Skin Protection | Since the discovery of antioxidant responsive elements (ARE), which are commonly found in the promoter of the Phase II metabolism/antioxidant enzymes, and nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that binds to ARE, the study conducted in this field has expanded remarkably over the decades, and the Nrf2-mediated pathway is now recognized to occupy a central position in cell defense mechanisms. Induction of the Phase II metabolism/antioxidant enzymes through direct activation of Nrf2 can be a promising strategy for preventing degenerative diseases in general, but a dark side of this strategy should be considered, as Nrf2 activation can enhance the survival of cancer cells. In this review, we discuss the historical discovery of Nrf2 and the regulatory mechanism of the Nrf2-mediated pathway, focusing on the interacting proteins and post-translational modifications. In addition, we discuss the latest studies that examined various natural Nrf2 modulators for the protective roles in the skin, in consideration of their dermatological and cosmetic applications. Studies are reviewed in the order of time of research as much as possible, to help understand how and why such studies were conducted under the circumstances of that time. We hope that this review can serve as a steppingstone in conducting more advanced research by providing a scientific basis for researchers newly entering this field. | Boo, Yong Chool | Kyungpook Natl Univ, Cell & Matrix Res Inst, BK21 Plus KNU Biomed Convergence Program, Sch Med,Dept Mol Med, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 1.04 | 2025-06-25 | 58 | 56 | nuclear factor erythroid 2-related factor 2 (Nrf2); antioxidant responsive elements (ARE); kelch-like ECH-associated protein 1 (Keap1); β -transducin repeat-containing protein (β -TrCP); phosphorylation; acetylation; natural products; terrestrial and marine plants; inflammation; aging; cancer | ANTIOXIDANT RESPONSE ELEMENT; TRANSCRIPTION FACTOR NRF2; INDUCED OXIDATIVE STRESS; YA-SUBUNIT GENE; CONTROLLING INDUCIBLE EXPRESSION; KERATINOCYTE HACAT CELLS; CUL3-BASED E3 LIGASE; UP-REGULATION; FUNCTIONAL-CHARACTERIZATION; HEME OXYGENASE-1 | Acetylation; Aging; Antioxidant responsive elements (ARE); Cancer; Inflammation; Kelch-like ECH-associated protein 1 (Keap1); Natural products; Nuclear factor erythroid 2-related factor 2 (Nrf2); Phosphorylation; Terrestrial and marine plants; β-transducin repeat-containing protein (β-TrCP) | English | 2020 | 2020-09 | 10.3390/antiox9090812 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Neuroprotective Effects of Euonymus alatus Extract on Scopolamine-Induced Memory Deficits in Mice | Euonymus alatus is considered to elicit various beneficial effects against cancer, hyperglycemia, menstrual discomfort, diabetic complications, and detoxification. The young leaves of this plant are exploited as food and also utilized for traditional medicine in East Asian countries, including Korea and China. Our preliminary study demonstrated that ethanolic extract from the Euonymus alatus leaf (EAE) exhibited the strongest antioxidant enzyme-inducing activity among more than 100 kinds of edible tree leaf extracts. This study investigated whether EAE could attenuate the cognitive deficits caused by oxidative stress in mice. Oral intubation of EAE at 100 mg/kg bw or higher resulted in significant improvements to the memory and behavioral impairment induced via i.p. injection of scopolamine. Furthermore, EAE enhanced the expression levels of hippocampal neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor in mice, activated the Nrf2, and the downstream heme oxygenase-1 (HO-1) a quintessential antioxidant enzyme. As rutin (quercetin-3-O-rutinose) was abundantly present in EAE and free quercetin was able to induce defensive antioxidant enzymes in an Nrf2-dependent manner, our findings suggested that quercetin derived from rutin via the intestinal microflora played a significant role in the protection of the mouse hippocampus from scopolamine-induced damage through BDNF-mediated Nrf2 activation, thereby dampening cognitive decline. | Woo, Yunju; Lim, Ji Sun; Oh, Jisun; Lee, Jeong Soon; Kim, Jong-Sang | Kyungpook Natl Univ, Sch Food Sci & Biotechnol BK21 Plus, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea; Forest Resources Dev Inst Gyeongsangbuk Do, Andong 36605, South Korea | 58328006000; 57202909530; 56311554100; 7601460624; 37106950100 | dndbswn123@naver.com;lzsunny@daum.net;j.oh@knu.ac.kr;ljs7942@korea.kr;vision@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 1.63 | 2025-06-25 | 33 | 33 | Euonymus alatus; antioxidant; BDNF; cognition improvement; neuroprotective; HT22 cells; animal model | ANTIOXIDANT ACTIVITY; ALZHEIMERS-DISEASE; CHEMICAL-CONSTITUENTS; QUERCETIN; BRAIN; ACETYLCHOLINESTERASE; IMPAIRMENT; NEURONS; RUTIN; DPPH | Animal model; Antioxidant; BDNF; Cognition improvement; Euonymus alatus; HT22 cells; Neuroprotective | English | 2020 | 2020-05 | 10.3390/antiox9050449 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Panax ginseng Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis | Periodontitis is an infectious inflammatory disease of tissues around teeth that destroys connective tissues and is characterized by the loss of periodontal ligaments and alveolar bone. A new treatment strategy is needed owing to the limitations of the current surgical treatment method and the side effects of anti-inflammatory drugs. Therefore, here, we assessed whether Panax ginseng fruit extract (PGFE) is a new therapeutic agent for periodontitis in vitro and in vivo. According to the results, PGFE suppressed pro-inflammatory cytokines such as tumor necrosis factor-alpha, interleukin (IL)-1 beta, and IL-6, and pro-inflammatory mediators such as inducible nitric oxide synthase and cyclooxygenase-2 through heme oxygenase-1 expression in human periodontal ligament cells stimulated with Porphyromonas gingivalis lipopolysaccharide (PG-LPS). In addition, the osteogenic induction of human periodontal ligament cells was inhibited by PG-LPS, and protein and mRNA levels of osteogenic markers such as alkaline phosphatase, collagen type 1 (COL1), osteopontin (OPN), and runt-related transcription factor 2 (RUNX2) were increased. The efficacy of PGFE for inhibiting periodontitis in vitro was demonstrated in a representative in vitro model of periodontitis induced by ligature and PG-LPS. Subsequently, hematoxylin and eosin staining and micro-computed tomography of the euthanized experimental animal model confirmed suppressed periodontal inflammation, which is an important strategy for treating periodontitis and for recovering the resulting alveolar bone loss. Therefore, PGFE is a potential, novel therapeutic agent for periodontal diseases. | Kim, Eun-Nam; Kim, Tae-Young; Park, Eui Kyun; Kim, Jae-Young; Jeong, Gil-Saeng | Keimyung Univ, Coll Pharm, 1095 Dalgubeol Daero, Daegu 42601, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Biochem, IHBR, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Pathol, Daegu 41940, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Regenerat Med, Daegu 41940, South Korea | Kim, Ji-Youn/A-5779-2017 | 57201655294; 57208461628; 37071072400; 56812734700; 57204396456 | enkimpharm@gmail.com;tae09290@gmail.com;epark@knu.ac.kr;jykim91@knu.ac.kr;gsjeong@kmu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 12 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 0.89 | 2025-06-25 | 21 | 22 | periodontitis; Porphyromonas gingivalis; heme oxygenase-1; Panax ginseng fruit extract; osteogenic differentiation | ALVEOLAR BONE LOSS; OXIDATIVE STRESS; MC3T3-E1 CELLS; HEME; LIPOPOLYSACCHARIDE; OXYGENASE-1; INHIBITION; EXPRESSION; RISK | Heme oxygenase-1; Osteogenic differentiation; Panax ginseng fruit extract; Periodontitis; Porphyromonas gingivalis | English | 2020 | 2020-12 | 10.3390/antiox9121221 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Article | Peroxiredoxin ii maintains the mitochondrial membrane potential against alcohol-induced apoptosis in ht22 cells | Excessive alcohol intake can significantly reduce cognitive function and cause irreversible learning and memory disorders. The brain is particularly vul nerable to alcohol-induced ROS damage; the hippocampus is one of the most sensitive areas of the brain for alcohol neurotoxicity. In the present study, we observed significant increasing of intracellular ROS accumulations in Peroxiredoxin II (Prx II) knockdown HT22 cells, which were induced by alcohol treatments. We also found that the level of ROS in mitochondrial was also increased, resulting in a decrease in the mitochondrial membrane potential. The phosphorylation of GSK3β (Ser9) and anti-apoptotic protein Bcl2 expression levels were significantly downregulated in Prx II knockdown HT22 cells, which suggests that Prx II knockdown HT22 cells were more susceptible to alcohol-induced apoptosis. Scavenging the alcohol-induced ROS with NAC significantly decreased the intracellular ROS levels, as well as the phosphorylation level of GSK3β in Prx II knockdown HT22 cells. Moreover, NAC treatment also dramatically restored the mitochondrial membrane potential and the cellular apoptosis in Prx II knockdown HT22 cells. Our findings suggest that Prx II plays a crucial role in alcohol-induced neuronal cell apoptosis by regulating the cellular ROS levels, especially through regulating the ROS-dependent mitochondrial membrane potential. Consequently, Prx II may be a therapeutic target molecule for alcohol-induced neuronal cell death, which is closely related to ROS-dependent mitochondria dysfunction. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. | Jin, Mei-Hua; Yu, Jia-Bin; Sun, Hu-Nan; Jin, Ying-Hua; Shen, Gui-Nan; Jin, Cheng-Hao; Cui, Yu-Dong; Lee, Dong-Seok; Kim, Sun-Uk; Kim, Ji-Su; Kwon, Taeho; Han, Ying-Hao | College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; Library and Information Center, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China; School of Life Sciences, KNU Creative BioResearch Group (BK21 plus project), Kyungpook National University, Daegu, 41566, South Korea; Futuristic Animal Resource & Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju-si, 28116, Chungcheongbuk-do, South Korea; Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, 56216, Jeonbuk, South Korea; Primate Resources Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup-si, 56216, Jeonbuk, South Korea; College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, 163319, Heilongjiang, China | 57740660100; 57212761576; 8603267900; 8610761600; 36193289800; 56535785100; 24342913900; 57210068061; 8278891100; 39461534900; 57202850676; 7404096642 | kimjs@kribb.re.kr; | Antioxidants | ANTIOXIDANTS-BASEL | N/A | 2076-3921 | 9 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 0.67 | 2025-06-25 | 19 | Alcohol; Neuronal cell; Oxidative damage; Prx II; ROS | English | Final | 2020 | 10.3390/antiox9010001 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Phytochemical Characterization of Dillenia indica L. Bark by Paper Spray Ionization-Mass Spectrometry and Evaluation of Its Antioxidant Potential Against t-BHP-Induced Oxidative Stress in RAW 264.7 Cells | The antioxidant effects of the ethyl acetate fraction of Dillenia indica bark (DIBEt) and the underlying mechanisms were investigated in tert-butyl hydroperoxide (t-BHP)-stimulated oxidative stress in RAW 264.7 cells. Paper spray ionization-mass spectroscopy with positive-ion mode tentatively revealed 27 secondary metabolites in D. indica bark extract; predominant among them were alkaloids, phenolic acids, and flavonoids. A new triterpenoid (nutriacholic acid) was confirmed in DIBEt for the first time. DIBEt had strong free radical-scavenging capabilities and was also able to reduce t-BHP-induced cellular reactive oxygen species (ROS) generation in RAW 264.7 cells. DIBEt was found to prevent oxidative stress by boosting the levels of heme oxygenase-1 (HO-1) through the up-regulation of nuclear factor erythroid 2-related factor 2 (Nrf2) via the regulation of extracellular signal-regulated kinase (ERK) phosphorylation in RAW 264.7 cells. These results support the potential of DIBEt for defense against oxidative stress-stimulated diseases. | Alam, Md Badrul; Ahmed, Arif; Islam, Syful; Choi, Hee-Jeong; Motin, Md Abdul; Kim, Sunghwan; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Inner Beauty Antiaging Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA; Mass Spectrometry Converging Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea; Knu BnC, Daegu 41566, South Korea | Islam, Syful/AAZ-5084-2021; Kim, Sunghwan/HKN-9812-2023; Alam, Md Badrul/AFL-7668-2022; Ahmed, Arif/K-6456-2019; Lee, Seung Eun/ABG-1607-2021; ALAM, MD BADRUL/AFL-7668-2022 | 56706777100; 55758288700; 57213340400; 57201125608; 6603422454; 57203772967; 57221453703 | mbalam@knu.ac.kr;arifahmed83@gmail.com;msi412@yahoo.com;choi930302@gmail.com;mdabdulm@ucr.edu;sunghwank@knu.ac.kr;sang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 9 | 11 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2020 | 6.313 | 7.3 | 1.11 | 2025-06-25 | 23 | 25 | antioxidant; Dillenia indica; heme oxygenase 1 (HO-1); nuclear factor erythroid 2-related factor 2 (Nrf2); RAW 264; 7 cells | REACTIVE OXYGEN; ACID; NARINGENIN; CAPACITY; EXTRACTS; PATHWAY; POWER | Antioxidant; Dillenia indica; Heme oxygenase 1 (HO-1); Nuclear factor erythroid 2-related factor 2 (Nrf2); RAW 264.7 cells | English | 2020 | 2020-11 | 10.3390/antiox9111099 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Regional and seasonal detection of resistance mutation frequencies in field populations of Anopheles Hyrcanus Group and Culex pipiens complex in Korea | Pyrethroid (PYR) and organophosphate (OP) insecticides have been extensively used for mosquito control for several decades in South Korea, and has resulted in the rapid development of resistance in the field. In this study, quantitative sequencing (QS) protocols were developed for the frequency prediction of insecticide resistance alleles [e.g., the L1014F/C mutation on the voltage sensitive sodium channel as a PYR resistance allele and the G119S mutation on the acetylcholinesterase 1 as OP resistance alleles] in four regional populations of Anopheles Hyrcanus Group and Culex pipiens complex. Both of the L1014F/C and G119S mutations were observed in all examined regional populations of An. Hyrcanus Group, suggesting a wide distribution of both PYR and OP resistance. In contrast, populations of the Cx. pipiens complex were determined to possess almost no G119S mutation, but relatively higher frequencies of the L1014F mutation, showing differential resistance patterns between different mosquito groups. The mutation frequencies were also monitored throughout a mosquito season (May-October) at one collection site to determine the seasonal changes of resistance mutation frequency in mosquito populations. Dramatic decreases of both L1014F/C and G119S mutation frequencies were observed in the An. Hyrcanus Group toward the fall, with no mutations observed in the early spring, suggesting a connection between the fitness costs of overwintering and insecticide resistance. However, no apparent trends were detectable in the Cx. pipiens complex populations due to low or zero mutation frequencies. | Lee, Do Eun; Kim, Heung-Chul; Chong, Sung-Tae; Klein, Terry A.; Choi, Kwang Shik; Kim, Young Ho; Kim, Ju Hyeon; Lee, Si Hyeock | Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea; Med Dept Act Korea, Force Hlth Protect & Prevent Med, 65th Med Bridge,Unit 15281, APO, AP 96271 USA; Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Ecol Sci, Sangju 37224, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea | Lee, Sang/R-7470-2019; Kim, Young/J-5414-2012 | 57212527818; 8847173600; 11840251100; 7202313728; 36602283400; 58516491300; 35317802600; 34872664900 | biomyst5@snu.ac.kr;shlee22@snu.ac.kr; | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | PESTIC BIOCHEM PHYS | 0048-3575 | 1095-9939 | 164 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2020 | 3.963 | 7.3 | 0.32 | 2025-06-25 | 9 | 9 | Mosquito; Insecticide resistance; Resistance mutation frequency; Quantitative sequencing; Voltage-sensitive sodium channel; Acetylcholinesterase | TIME PCR AMPLIFICATION; INSECTICIDE RESISTANCE; ALLELE-FREQUENCY; PYRETHROID RESISTANCE; SINENSIS DIPTERA; DISEASE VECTORS; POOLED DNA; CULICIDAE; KLEINI; VIVAX | Acetylcholinesterase; Insecticide resistance; Mosquito; Quantitative sequencing; Resistance mutation frequency; Voltage-sensitive sodium channel | Animals; Anopheles; Culex; Insecticide Resistance; Insecticides; Mutation; Mutation Rate; Republic of Korea; insecticide; animal; Anopheles; Culex; insecticide resistance; mutation; mutation rate; South Korea | English | 2020 | 2020-03 | 10.1016/j.pestbp.2019.12.005 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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