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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | An Inversion-Free Robust Power-Flow Algorithm for Microgrids | Recently, several numerical algorithms have been proposed to solve the power flow (PF) problems of islanded microgrids (MGs). However, these algorithms approximate the steady-state model of the distributed generation units (DGs) as linear equations. In some cases, this linear approximation leads to inaccurate PF solutions due to dead-zone and generation limits of the given DGs. To fill this gap, we propose a new non-linear approximation of the steady-state model of the DGs considering dead-zone and generation limits of the DG. Besides, an inversion-free PF algorithm based on the improved Newton-Traub composition (INTC) is proposed for solving PF problems of grid-connected and islanded MGs more robustly and accurately, where the inverse of the Jacobian matrix is updated by using the Broyden's method. To include the power losses of the neutral conductor and grounding resistance, four-conductor based PF formulation is proposed. The numerical results on several test systems suggest that the proposed algorithm can provide an accurate steady-state solution as compared to other state-of-the-art algorithms. | Kumar, Abhishek; Das, Swagatam; Mallipeddi, Rammohan | Indian Inst Technol BHU Varanasi, Dept Elect Engn, Varanasi 221005, Uttar Pradesh, India; Indian Stat Inst, Elect & Commun Sci Unit, Kolkata 700108, India; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu 41566, South Korea | Das, Swagatam/AAG-6753-2019; Mallipeddi, Rammohan/AAL-5306-2020; Kumar, Abhishek/ABA-5251-2021 | 57206266703; 24729258600; 25639919900 | abhishek.kumar.eee13@iitbhu.ac.in;swagatam.das@isical.ac.in;mallipeddi@knu.ac.kr; | IEEE TRANSACTIONS ON SMART GRID | IEEE T SMART GRID | 1949-3053 | 1949-3061 | 12 | 4 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 10.275 | 6.0 | 0.78 | 2025-07-30 | 14 | 14 | Jacobian matrices; Steady-state; Reactive power; Voltage control; Tools; Optimization; Convergence; Power flow problem; islanded microgrid; distributed generation unit; Newton-Traub composition; neutral conductor; grounding resistance | BACKWARD/FORWARD SWEEP ALGORITHM; PARALLEL-CONNECTED INVERTERS; NEWTON-RAPHSON; SYSTEMS; OPERATION | distributed generation unit; grounding resistance; islanded microgrid; neutral conductor; Newton-Traub composition; Power flow problem | Electric grounding; Inverse problems; Jacobian matrices; Microgrids; Distributed generation unit (DGs); Grounding resistance; Linear approximations; Neutral conductor; Nonlinear approximation; Numerical algorithms; Steady state solution; Steady-state modeling; Electric load flow | English | 2021 | 2021-07 | 10.1109/tsg.2021.3064656 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Anti-glycation effect of Ecklonia cava polysaccharides extracted by combined ultrasound and enzyme-assisted extraction | The anti-glycation effects of polysaccharides from Ecklonia cava were examined according to extraction method-hot buffer (HP), ultrasound (UP), enzyme (EP), or a combination of ultrasound and enzyme (UEP). The physicochemical properties, monosaccharide compositions, and structural characteristics of the polysaccharides were determined. UP, EP, and UEP had higher fucose and galactose compositions than HP. The FT-IR spectra of samples showed the presence of sulfate esters and 4-sulfate galactose. H-1 NMR indicated that alginate was removed by purification. UP, EP, and UEP possessed higher sulfate contents than HP. UEP presented with the highest extraction yield and lowest protein and uronic add contents. The levels of AGE formation, as well as fructosamine, alpha-dicarbonyl, and protein carbonyl contents were determined during a 3-week incubation in a BSA/fructose system. UEP and UP effectively inhibited AGE, although the inhibition effect was lower than that of aminoguanidine. However, UP and UEP showed higher inhibition of fructosamine, alpha-dicarbonyl, and protein carbonyl than aminoguanidine. AGE formation was negatively correlated with sulfate content and some monosaccharide compositions (fucose, galactose, and glucose), but positively correlated with molecular weight Overall, the present study suggests that UEP is a suitable extraction method for obtaining anti-glycation agents from E. cava. (C) 2021 Elsevier B.V. All rights reserved. | Park, Jong Jin; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Technol, Daegu 41566, South Korea | Lee, Wonyoung/AAL-2780-2021; Park, Jongjin/AAL-3484-2021 | 58602432200; 57195940408 | wonyoung@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 180 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 2.26 | 2025-07-30 | 36 | 38 | Anti-glycation; Ecklonia cava; Polysaccharide; Extraction method | IN-VITRO ANTIOXIDANT; MONOSACCHARIDE COMPOSITION; FUCOIDAN; FRUIT; ANTIGLYCATION; OPTIMIZATION; INHIBITION; SPOROPHYLL; OXIDATION | Anti-glycation; Ecklonia cava; Extraction method; Polysaccharide | Glucan 1,4-alpha-Glucosidase; Glycosylation; Magnetic Resonance Spectroscopy; Molecular Weight; Monosaccharides; Phaeophyta; Polysaccharides; Solubility; Spectroscopy, Fourier Transform Infrared; Sulfates; Ultrasonics; Uronic Acids; 4 sulfate galactose; advanced glycation end product; alginic acid; alpha dicarbonyl; aminoguanidine; bovine serum albumin; buffer; carbonyl derivative; ester derivative; fructosamine; fructose; fucose; galactose; glucose; polysaccharide; protein; protein carbonyl; sulfate; sulfate ester derivative; unclassified drug; uronic acid; glucan 1,4 alpha glucosidase; monosaccharide; polysaccharide; sulfate; anti glycation effect; Article; chemical reaction; controlled study; Ecklonia cava; enzyme assisted extraction; Fourier transform infrared spectroscopy; incubation time; molecular weight; nonhuman; proton nuclear magnetic resonance; purification; ultrasound assisted extraction; brown alga; chemistry; drug effect; glycosylation; infrared spectroscopy; isolation and purification; metabolism; nuclear magnetic resonance spectroscopy; procedures; solubility; ultrasound | English | 2021 | 2021-06-01 | 10.1016/j.ijbiomac.2021.03.118 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Influence of cellulose nanocrystal addition on the production and characterization of bacterial nanocellulose | Bacterial nanocellulose (BNC) is characterized by high purity and excellent mechanical properties; however, its production is constrained by low yield. Therefore, efforts aimed at improving its yield and material properties are imperative. This study investigated the effect of adding different concentrations (0%, 0.5%, and 1.0%) of cellulose nanocrystal (CNC) in Hestrin-Schramm modified medium on the yield and properties of BNC produced by Komagataeibacter sp. SFCB22-18. The BNC yield increased as following an increase in added CNC concentration. Also, the morphology, structure, crystallinity, thermal stability, and mechanical properties of BNC improved after CNC incorporation. A low CNC concentration (0.1%) favored mechanical strength, whereas 0.5% gave the optimum morphology, structural, and thermal stability. These results showed that modifying BNC with CNC could help increase yield and improve its properties, and thus; the potentiality of BNC in various applications would be much enhanced. | Bang, Won Yeong; Adedeji, Olajide Emmanuel; Kang, Hye Jee; Kang, Mi Dan; Yang, Jungwoo; Lim, Young Woon; Jung, Young Hoon | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Ildong Biosci, Pyeongtaek Si 17957, Gyeonggi Do, South Korea; Fed Univ Wukari, Dept Food Sci & Technol, PMB 1020, Wukari, Nigeria; Seoul Natl Univ, Sch Biol Sci, Seoul 08826, South Korea; Seoul Natl Univ, Inst Microbiol, Seoul 08826, South Korea | ; Jung, Young/F-1703-2013; Adedeji, Olajide/GYU-3066-2022 | 57208701768; 57202229091; 57219656318; 57311023600; 56076383700; 7402565072; 55550063700 | yeong0417@ildong.com;adedeji@fuwukari.edu.ng;hyejee@knu.ac.kr;yjw@ildong.com;ywlim@snu.ac.kr;younghoonjung@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 193 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 1.26 | 2025-07-30 | 19 | 25 | Bacterial nanocellulose; Cellulose nanocrystal; Komagataeibacter | NANOCOMPOSITES; FERMENTATION; IMPROVEMENT; WASTE | Bacterial nanocellulose; Cellulose nanocrystal; Komagataeibacter | Acetobacteraceae; Cellulose; Nanoparticles; Nanostructures; acetic acid; alcohol; bacterial nanocellulose; cellulose nanocrystal; glucose; nanocellulose; unclassified drug; cellulose; nanomaterial; nanoparticle; Article; bacterial structures; bacterium; concentration (parameter); crystallization; fermentation; Fourier transform infrared spectroscopy; high performance liquid chromatography; Komagataeibacter; mechanics; microbial growth; morphology; nonhuman; scanning electron microscopy; thermogravimetry; thermostability; X ray diffraction; Acetobacteraceae; biosynthesis; chemistry; metabolism | English | 2021 | 2021-12-15 | 10.1016/j.ijbiomac.2021.10.092 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Nitric oxide-releasing poly(ε-caprolactone)/S-nitrosylated keratin biocomposite scaffolds for potential small-diameter vascular grafts | Rapid endothelialization and regulation of smooth muscle cell proliferation are crucial for small-diameter vascular grafts to address poor compliance, thromboembolism, and intimal hyperplasia, and achieve revascularization. As a gaseous signaling molecule, nitric oxide (NO) regulates cardiovascular homeostasis, inhibits blood clotting and intimal hyperplasia, and promotes the growth of endothelial cells. Due to the instability and burst release of small molecular NO donors, a novel biomacromolecular donor has generated increasing interest. In the study, a low toxic NO donor of S-nitrosated keratin (KSNO) was first synthesized and then coelectrospun with poly(epsilon-caprolactone) to afford NO-releasing small-diameter vascular graft. PCL/KSNO graft was capable to generate NO under the catalysis of ascorbic acid (Asc), so the graft selectively elevated adhesion and growth of human umbilical vein endothelial cells (HUVECs), while inhibited the proliferation of human aortic smooth muscle cells (HASMCs) in the presence of Asc. In addition, the graft displayed significant antibacterial properties and good blood compatibility. Animal experiments showed that the biocomposite graft could inhibit thrombus formation and preserve normal blood flow via single rabbit carotid artery replacement for 1 month. More importantly, a complete endothelium was observed on the lumen surface. Taken together, PCL/KSNO smalldiameter vascular graft has potential applications in vascular tissue engineering with rapid endothelialization and vascular remolding. | Li, Pengfei; Jin, Dawei; Dou, Jie; Wang, Lijuan; Wang, Yanfang; Jin, Xingxing; Han, Xiao; Kang, Inn-Kyu; Yuan, Jiang; Shen, Jian; Yin, Meng | Nanjing Normal Univ, Dept Mat Sci & Engn, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci,Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China; Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Cardiothorac Surg, 1678 Dong Fang Rd, Shanghai 200127, Peoples R China; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 702701, South Korea | Han, Xiaoxiang/KDO-8815-2024; Shen, jian/GQO-8955-2022; Yuan, J/AAA-3774-2022 | 55763396700; 57191159532; 8534274200; 57218275210; 56884894300; 57189098548; 57216534588; 7203062733; 7403402152; 57199270806; 24330176900 | bioalchem@yahoo.com;jshen@njnu.edu.cn;yinmengmdphd@163.com; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 189 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 2.19 | 2025-07-30 | 37 | 36 | Keratin; Nitric oxide; Scaffold for small-diameter vascular grafts; Electrospinning | ASCORBIC-ACID; NO-RELEASE; NANOPARTICLES; FABRICATION | Electrospinning; Keratin; Nitric oxide; Scaffold for small-diameter vascular grafts | Animals; Aorta; Biocompatible Materials; Blood Vessel Prosthesis; Cell Adhesion; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Escherichia coli; Hemolysis; Human Umbilical Vein Endothelial Cells; Humans; Keratins; Mice; Microbial Sensitivity Tests; Myocytes, Smooth Muscle; Nitric Oxide; Nitrosation; Platelet Adhesiveness; Polyesters; Rabbits; Spectroscopy, Fourier Transform Infrared; Tissue Scaffolds; ascorbic acid; butyl nitrite; citrate sodium; collagen; copper ion; cysteine; hexafluoro 2 propanol; keratin; mercaptoethanol; nitric oxide; nitrogen; polycaprolactone; s nitrosylated keratin; unclassified drug; biomaterial; keratin; nitric oxide; polycaprolactone; polyester; animal cell; animal experiment; animal model; animal tissue; antibacterial activity; aortic smooth muscle cell; Article; attenuated total reflectance Fourier transform infrared spectroscopy; blood clotting; blood compatibility; blood flow velocity; blood vessel graft; carotid artery replacement; catalysis; cell proliferation; cell suspension; cell viability; controlled study; cytology; cytotoxicity; degradability; duplex ultrasound; elemental composition; endothelialization; enzymatic degradation; fluorescence microscopy; hemolysis; human; human cell; HUVEC cell line; hydrophilicity; immunofluorescence assay; incubation time; intimal hyperplasia; Leporidae; morphology; MTT assay; nanofabrication; NCTC clone 929 cell line; nonhuman; scanning electron microscopy; smooth muscle cell; temperature; thermal decomposition; thrombocyte adhesion; thromboembolism; thrombosis; ultraviolet irradiation; water contact angle measurement; X ray diffraction; X ray photoemission spectroscopy; animal; aorta; blood vessel prosthesis; cell adhesion; cell death; cell line; cell survival; chemistry; Escherichia coli; growth, development and aging; infrared spectroscopy; metabolism; microbial sensitivity test; mouse; nitrosation; tissue scaffold; umbilical vein endothelial cell | English | 2021 | 2021-10-31 | 10.1016/j.ijbiomac.2021.08.147 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Potential applications of bacterial cellulose and its composites for cancer treatment | Bacterial cellulose (BC) has received immense interest in medical, pharmaceutical, and other related fields owing to its intrinsic physical, mechanical, and biological features. Its structural features offer an ideal environment for developing composites, thereby further extending its areas of applications. BC was initially used in wound dressing, artificial blood vessels, organ development, and tissue regeneration; however, the recent focus has switched to 3D printing techniques. BC can serve as suitable material for treating different cancers due to unique liquid absorbing and drug loading properties. BC-based scaffolds have been synthesized and tested for in vitro culturing of cancer cells to simulate tumor microenvironments. These scaffolds support normal growth of cancer cells, particularly breast and ovarian cancer cells, showing significant adhesion, proliferation, ingrowth, and differentiation. This review describes the different approaches of manipulating BC for use in medicine, with particular focus on the applications of BC composites in cancer treatment. A detailed discussion about various formulations of BC in multiple cancer therapeutics is summarized. (C) 2020 Elsevier B.V. All rights reserved. | Ul Islam, Salman; Ul-Islam, Mazhar; Ahsan, Haseeb; Ahmed, Muhammad Bilal; Shehzad, Adeeb; Fatima, Atiya; Sonn, Jong Kyung; Lee, Young Sup | Kyungpook Natl Univ, Coll Nat Sci, Sch Life Sci, Daegu 41566, South Korea; Dhofar Univ, Coll Engn, Dept Chem Engn, Salalah, Oman; Univ Peshawar, Fac Life & Environm Sci, Dept Pharm, Khyber Pakhtunkhwa 25120, Pakistan; Natl Univ Sci & Technol, Sch Mech & Mfg Engn, Dept Biomed Engn & Sci, Islamabad, Pakistan; Imam Abdulrahman bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Clin Pharm, Dammam, Saudi Arabia | Shehzad, Adeeb/HHN-4847-2022; Fatima, Atiya/D-3801-2009 | 56985186700; 37125198700; 57531232400; 58689879600; 36162526700; 57536876500; 35580853300; 36013628200 | yselee@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 168 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 3.85 | 2025-07-30 | 53 | 65 | Bacterial cellulose; Scaffolds; Wound dressings; Tissue engineering; Drug delivery; Tumor cell culture; Cancer treatment | TRANSDERMAL DELIVERY; MICROBIAL CELLULOSE; IMPLANT MATERIAL; BLOOD-VESSELS; IN-SITU; NANOCOMPOSITES; NANOPARTICLES; NANOCELLULOSE; MEMBRANES; HYDROGELS | Bacterial cellulose; Cancer treatment; Drug delivery; Scaffolds; Tissue engineering; Tumor cell culture; Wound dressings | Bacteria; Bacterial Proteins; Biocompatible Materials; Cellulose; Neoplasms; Tissue Engineering; Tissue Scaffolds; Wound Healing; bacterial polysaccharide; carboxymethylcellulose; cellulose; doxorubicin; drug carrier; fullerene; hydrogel; iron oxide nanoparticle; magnetic nanoparticle; methotrexate; nanoparticle; bacterial protein; biomaterial; cellulose; antineoplastic activity; Article; biocompatibility; breast cancer; cancer cell culture; cancer chemotherapy; cell adhesion; cell migration; cell proliferation; colon cancer; CT26 cell line; cytotoxicity; drug delivery system; drug formulation; human; nonhuman; pore size; skin cancer; bacterium; chemistry; neoplasm; physiology; procedures; tissue engineering; tissue scaffold; wound healing | English | 2021 | 2021-01-31 | 10.1016/j.ijbiomac.2020.12.042 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Production and characterization of biodegradable polyhydroxybutyrate by Micrococcus luteus isolated from marine environment | Marine microorganisms are reported to produce polyhydroxybutyrate (PHB) that has wide range of medical and industrial applications with the advantage of biodegradability. PHBs are synthesized as an energy and carbon storage element under metabolic pressure. The scope of this work is enhancing PHB production using marine microbial isolate, Micrococcus luteus by selectively optimizing various growth conditions such as different media components and growth parameters that influence the cell growth and PHB production were sampled. Micro-coccus luteus produced 7.54 g/L of PHB utilizing glucose as a carbon source and ammonium sulphate as a ni-trogen source with maximum efficiency. The same optimized operational conditions were further employed in batch fermentation over a time span of 72 h. Interestingly higher cell dry weight of 21.52 g/L with PHB yield of 12.18 g/L and 56.59% polymer content was observed in batch fermentation studies at 64 h. The chemical nature of the extracted polymer was validated with physio-chemical experiments and was at par with the commercially available PHB. This study will spotlight M. luteus as a potential source for large-scale industrial production of PHB with reducing environmental pollutions. | Mohanrasu, K.; Rao, R. Guru Raj; Dinesh, G. H.; Zhang, Kunyu; Sudhakar, Muniyasamy; Pugazhendhi, A.; Jeyakanthan, J.; Ponnuchamy, Kumar; Govarthanan, M.; Arun, A. | Alagappa Univ, Dept Microbiol, Karaikkudi, Tamil Nadu, India; Alagappa Univ, Dept Bioinformat, Struct Biol & Bio Comp Lab, Karaikkudi 630004, Tamil Nadu, India; Tianjin Univ, Sch Chem Engn & Technol, Tianjin, Peoples R China; CSIR Chem Cluster Adv Polymers & Composites Res, Pretoria, South Africa; Nelson Mandela Univ, Dept Chem, Port Elizabeth, South Africa; Ton Duc Thang Univ, Fac Environm & Labour Safety, Innovat Green Product Synth & Renewable Environm, Ho Chi Minh City, Vietnam; Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu, South Korea | Arun, Alagarsamy/F-8986-2019; Muniyasamy, Sudhakar/AAH-6879-2019; Ponnuchamy, Kumar/D-3470-2013; Muthusamy, Govarthanan/C-1491-2014; Muniyasamy, Sudhakar/K-8592-2015; Govarthanan, Muthusamy/C-1491-2014; Pugazhendhi, Arivalagan/F-5411-2018; Ravi, Guru Raj Rao/ADN-6941-2022; Arun, A./F-8986-2019 | 57202300780; 57219604789; 57215022798; 55474994900; 57226007770; 57191625854; 8885182100; 55173720800; 54881927600; 57078221100 | raasumohan12@gmail.com;gova.muthu@gmail.com;arunalacha@gmail.com; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 186 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 0.8 | 2025-07-30 | 16 | 22 | Polyhydroxybutyrate; Optimization; Fermentation; Bioreactor; Marine bacteria; Thermo gravimetric analysis (TGA) | BACTERIAL POLYHYDROXYALKANOATES; PHB PRODUCTION; CARBON SOURCE; VIBRIO SP; OPTIMIZATION; ENHANCEMENT; CULTURE; XYLOSE; WASTE; WATER | Bioreactor; Fermentation; Marine bacteria; Optimization; Polyhydroxybutyrate; Thermo gravimetric analysis (TGA) | Fermentation; Geologic Sediments; Hydrogen-Ion Concentration; Hydroxybutyrates; Industrial Microbiology; Micrococcus luteus; Molecular Structure; Temperature; Time Factors; ammonium chloride; ammonium sulfate; arabinose; glucose; glycerol; glycine; lactic acid; lactose; mannitol; poly(3 hydroxybutyric acid); potassium nitrate; starch; sucrose; urea; hydroxybutyric acid; Article; bacterial growth; bacterium isolate; batch fermentation; biodegradability; biomass production; carbon source; controlled study; culture optimization; differential scanning calorimetry; Fourier transform infrared spectroscopy; incubation temperature; incubation time; marine environment; melting point; Micrococcus luteus; nonhuman; pH; physical chemistry; pollution; proton nuclear magnetic resonance; thermogravimetry; ultraviolet visible spectrophotometry; X ray diffraction; chemical structure; fermentation; growth, development and aging; isolation and purification; metabolism; microbiology; Micrococcus luteus; sediment; temperature; time factor | English | 2021 | 2021-09-01 | 10.1016/j.ijbiomac.2021.07.029 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | PTP1B inhibition studies of biological active phloroglucinols from the rhizomes of Dryopteris crassirhizoma: Kinetic properties and molecular docking simulation | By various chromatographic methods, 30 phloroglucinols (1-30) were isolated from a methanol extract of Dryopteris crassirhizoma, including two new dimeric phloroglucinols (13 and 25). The structures of the isolates were confirmed by HR-MS, 1D, and 2D NMR as well as by comparison with the literature. The protein tyrosine phosphatase 1B (PTP1B) effects of the isolated compounds (1-30) were evaluated using sodium orthovanadate and ursolic acid as a positive control. Among them, trimeric phloroglucinols 26-28 significantly exhibited the PTP1B inhibitory effects with the IC50 values of 1.19 +/- 0.13, 1.00 +/- 0.04, 1.23 +/- 0.05 mu M, respectively. In addition, the kinetic analysis revealed compounds 26-28 acted as competitive inhibitors against PTP1B enzyme with K-i values of 0.63, 0.61, 1.57 mu M, respectively. Molecular docking simulations were performed to demonstrate that these active compounds can bind with the catalytic sites of PTP1B with negative binding energies and the results are in accordance with that of the kinetic studies. In vitro and in silico results suggest that D. crassirhizoma rhizomes together with compounds 26-28 are potential candidates for treating type 2 diabetes. | Phong, Nguyen Viet; Oanh, Vu Thi; Yang, Seo Young; Choi, Jae Sue; Min, Byung Sun; Kim, Jeong Ah | Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, VOICE MRC, Vessel Organ Interact Res Ctr, Daegu 41566, South Korea; Sangji Univ, Dept Pharmaceut Engn, Wonju 26339, South Korea; Pukyong Natl Univ, Dept Food & Life Sci, Busan 48513, South Korea; Catholic Univ Daegu, Drug Res & Dev Ctr, Coll Pharm, Gyeongbuk, South Korea | Nguyen, Viet Phong/AAQ-4207-2021 | 57205196739; 57218248175; 57215036954; 25654629500; 55663638200; 24722570900 | jkim6923@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 188 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 1.59 | 2025-07-30 | 26 | 27 | Dryopteris crassirhizoma rhizomes; Phloroglucinols; Protein tyrosine phosphatase 1B; Kinetic; Molecular docking | TYROSINE-PHOSPHATASE 1B; IN-VITRO; PROTEIN; DERIVATIVES; CONSTITUENTS; ALKALOIDS; MECHANISM; ROOTS; ACID; BARK | Dryopteris crassirhizoma rhizomes; Kinetic; Molecular docking; Phloroglucinols; Protein tyrosine phosphatase 1B | Carbon-13 Magnetic Resonance Spectroscopy; Catalytic Domain; Dryopteris; Kinetics; Molecular Docking Simulation; Phloroglucinol; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Proton Magnetic Resonance Spectroscopy; Rhizome; alanine; arginine; butyrophenone; cystine; dryopcrassirine; dryopidin; flavaspidic acid; glycine; lysine; metadrenalin; methanol; methylene bis phlorobutyrophenone; monophenol monooxygenase; norflavaspidic acid; orthovanadic acid; phloroglucinol; plant extract; protein tyrosine phosphatase; protein tyrosine phosphatase 1B; serine; tyrosine; unclassified drug; ursolic acid; vanadate sodium; phloroglucinol; protein tyrosine phosphatase 1B; antifungal activity; Article; Bacillus subtilis; binding affinity; binding site; biological activity; carbon nuclear magnetic resonance; catalysis; chemical structure; column chromatography; computer model; controlled study; DPPH radical scavenging assay; Dryopteris crassirhizoma; electrospray mass spectrometry; enzyme activity; enzyme inhibition assay; enzyme kinetics; genetic algorithm; high performance liquid chromatography; hydroxyl radical scavenging assay; IC50; in vitro study; infrared spectroscopy; kinetics; liquid chromatography-mass spectrometry; molecular docking; molecular dynamics; MTT assay; non insulin dependent diabetes mellitus; nonhuman; nuclear magnetic resonance; nuclear magnetic resonance spectroscopy; physical chemistry; protein phosphorylation; proton nuclear magnetic resonance; Raman spectrometry; rhizome; thin layer chromatography; ultraviolet spectroscopy; X ray diffraction; chemistry; Dryopteris; enzyme active site; isolation and purification; kinetics; metabolism; rhizome | English | 2021 | 2021-10-01 | 10.1016/j.ijbiomac.2021.08.091 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function | Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co-agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain disorders with suppressed NMDAR function such as schizophrenia. However, it remains unclear whether other amino acid transporters expressed in the brain can also regulate brain glycine levels and NMDAR function. Here, we report that SLC6A20A, an amino acid transporter known to transport proline based on in vitro data but is understudied in the brain, regulates proline and glycine levels and NMDAR function in the mouse brain. SLC6A20A transcript and protein levels were abnormally increased in mice carrying a mutant PTEN protein lacking the C terminus through enhanced beta-catenin binding to the Slc6a20a gene. These mice displayed reduced extracellular levels of brain proline and glycine and decreased NMDAR currents. Elevating glycine levels back to normal ranges by antisense oligonucleotide-induced SLC6A20 knockdown, or the competitive GlyT1 antagonist sarcosine, normalized NMDAR currents and repetitive climbing behavior observed in these mice. Conversely, mice lacking SLC6A20A displayed increased extracellular glycine levels and NMDAR currents. Lastly, both mouse and human SLC6A20 proteins mediated proline and glycine transports, and SLC6A20 proteins could be detected in human neurons. These results suggest that SLC6A20 regulates proline and glycine homeostasis in the brain and that SLC6A20 inhibition has therapeutic potential for brain disorders involving NMDAR hypofunction. | Bae, Mihyun; Roh, Junyeop Daniel; Kim, Youjoung; Kim, Seong Soon; Han, Hye Min; Yang, Esther; Kang, Hyojin; Lee, Suho; Kim, Jin Yong; Kang, Ryeonghwa; Jung, Hwajin; Yoo, Taesun; Kim, Hyosang; Kim, Doyoun; Oh, Heejeong; Han, Sungwook; Kim, Dayeon; Han, Jinju; Bae, Yong Chul; Kim, Hyun; Ahn, Sunjoo; Chan, Andrew M.; Lee, Daeyoup; Kim, Jin Woo; Kim, Eunjoon | Inst for Basic Sci Korea, Ctr Synapt Brain Dysfunct, Daejeon, South Korea; Korea Adv Inst Sci & Technol KAIST, Dept Biol Sci, Daejeon, South Korea; Korea Res Inst Chem Technol, Therapeut & Biotechnol Div, Daejeon, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu, South Korea; Korea Univ, Coll Med, Dept Anat, Seoul, South Korea; Korea Univ, Coll Med, Div Brain Korea 21, Biomed Sci, Seoul, South Korea; KISTI, Div Natl Supercomp, Daejeon, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Chinese Univ Hong Kong, Sch Biomed Sci, Hong Kong, Peoples R China | Kim, Eunjoon/C-1566-2011; Kim, Seong Soon/IZE-2538-2023; Kim, Do Hyun/AAA-2792-2021; Chan, Andrew/J-9497-2013; Han, Jinju/D-9091-2017; Lee, Daeyoup/C-1653-2011; Kim, Ho/G-2712-2011 | 57205745911; 56973410500; 57221421317; 57194944619; 57204187581; 57194107730; 57203522541; 57202691999; 57193067987; 57210116788; 57203635335; 57189225581; 57192369940; 55868319700; 57221415128; 56911352000; 57221419827; 7406443048; 56377838800; 55663909700; 56714494700; 57213466926; 7406663229; 56813079600; 57203240554 | kime@kaist.ac.kr; | EMBO MOLECULAR MEDICINE | EMBO MOL MED | 1757-4676 | 1757-4684 | 13 | 2 | SCIE | MEDICINE, RESEARCH & EXPERIMENTAL | 2021 | 14.005 | 6.1 | 2.04 | 2025-07-30 | 38 | 38 | glycine transporter; neuropsychiatric disorders; NMDA receptor; PTEN; Slc6a20 | N-METHYLGLYCINE SARCOSINE; PTEN TUMOR-SUPPRESSOR; BETA-CATENIN; PHOSPHORYLATION SITES; NUCLEAR PTEN; BLOOD-BRAIN; CEREBROSPINAL-FLUID; MEDIATED RESPONSES; ORPHAN TRANSPORTER; SOCIAL-INTERACTION | glycine transporter; neuropsychiatric disorders; NMDA receptor; PTEN; Slc6a20 | Animals; Brain; Glycine; Glycine Plasma Membrane Transport Proteins; Homeostasis; Mice; Receptors, N-Methyl-D-Aspartate; amino acid transporter; antisense oligonucleotide; beta catenin; brain protein; glycine; glycine transporter 1; mutant protein; n methyl dextro aspartic acid receptor; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; proline; regulator protein; sarcosine; SLC6A20 transporter; unclassified drug; glycine; glycine transporter; n methyl dextro aspartic acid receptor; amino acid transport; animal cell; animal experiment; animal tissue; Article; brain disease; carboxy terminal sequence; climbing; compulsion; controlled study; electric current; extracellular matrix; gene; homeostasis; human; human cell; in vitro study; male; mental disease; mouse; nerve cell; nonhuman; normal value; protein binding; protein defect; protein depletion; protein function; regulatory mechanism; Slc6a20a gene; animal; brain; genetics; homeostasis; metabolism | English | 2021 | 2021-02-05 | 10.15252/emmm.202012632 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Structural basis for nucleotide-independent regulation of acyl-CoA thioesterase from Bacillus cereus ATCC 14579 | Acyl-CoA thioesterase is an enzyme that catalyzes the cleavage of thioester bonds and regulates the cellular concentrations of CoASH, fatty acids, and acyl-CoA. In this study, we report the crystal structure of acyl-CoA thioesterase from Bacillus cereus ATCC 14579 (BcACT1) complexed with the CoA product BcACT1 possesses a monomeric structure of a hotdog-fold and forms a hexamer via the tri meriza lion of three dimers. We identified the active site of BcACT1 and revealed that residues Asn23 and Asp38 are crucial for enzyme catalysis, indicating that BcACT1 belongs to the TE6 family. We also propose that BcACT1 might undergo an open-closed conformational change on the acyl-CoA binding pocket upon binding of the acyl-CoA substrate. Interestingly, the BcACT1 variants with dramatically increased activities were obtained during the site-directed mutagenesis experiments to confirm the residues involved in CoA binding. Finally, we found that BcACT1 is not nucleotide-regulated and suggest that the length and shape of the additional alpha 2-helix are crucial in determining a regulation mode by nucleotides. (C) 2020 Elsevier B.V. All rights reserved. | Park, Jiyoung; Kim, Yeo-Jin; Lee, Donghoon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea | Park, Jiyoung/MVY-3895-2025; Kim, Kyung-Jin/MVY-3405-2025 | 56188468900; 57203809529; 57207418964; 55510867400 | kkim@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 170 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2021 | 8.025 | 6.1 | 0.13 | 2025-07-30 | 4 | 2 | Bacillus cereus ATCC 14579; Acyl-CoA thioesterase; Nucleotide-independent regulation | Acyl-CoA thioesterase; Bacillus cereus ATCC 14579; Nucleotide-independent regulation | Acyl Coenzyme A; Amino Acid Sequence; Bacillus cereus; Catalytic Domain; Coenzyme A; Crystallography, X-Ray; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Substrate Specificity; Thiolester Hydrolases; palmitoyl coenzyme A hydrolase; acyl coenzyme A; coenzyme A; thiol ester hydrolase; alpha helix; Article; Bacillus cereus; binding site; catalysis; crystal structure; crystallization; enzyme active site; enzyme regulation; enzyme structure; gene amplification; hydrogen bond; nonhuman; polymerase chain reaction; process optimization; site directed mutagenesis; size exclusion chromatography; temperature measurement; amino acid sequence; Bacillus cereus; chemistry; enzyme specificity; enzymology; kinetics; metabolism; molecular model; ultrastructure; X ray crystallography | English | 2021 | 2021-02-15 | 10.1016/j.ijbiomac.2020.12.174 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A data-driven fault detection and diagnosis scheme for air handling units in building HVAC systems considering undefined states | Fault detection in heating, ventilation, and air conditioning (HVAC) systems is essential because faults lead to energy wastage, shortened lifespan of equipment, and uncomfortable indoor environments. In this study, we proposed a data-driven fault detection and diagnosis (FDD) scheme for air handling units (AHUs) in building HVAC systems to enable reliable maintenance by considering undefined states. We aimed to determine whether a neural-network-based FDD model can provide significant inferences for input variables using the supervised auto-encoder (SAE). We evaluated the fitness of the proposed FDD model based on the reconstruction error of the SAE. In addition, fault diagnosis is only performed by the FDD model if it can provide significant inferences for input variables; otherwise, feedback regarding the FDD model is provided. The experimental data of ASHRAE RP1312 were used to evaluate the performance of the proposed scheme. Furthermore, we compared the performance of the proposed model with those of well-known data-driven approaches for fault diagnosis. Our results showed that the scheme can distinguish between undefined and defined data with high performance. Furthermore, the proposed scheme has a higher FDD performance for the defined states than that of the control models. Therefore, the proposed scheme can facilitate the maintenance of the AHU systems in building HVAC systems. | Yun, Woo-Seung; Hong, Won-Hwa; Seo, Hyuncheol | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu, South Korea | ; Seo, Hyuncheol/ABC-5117-2020 | 57221104908; 7401527968; 56083741500 | charles@knu.ac.kr; | JOURNAL OF BUILDING ENGINEERING | J BUILD ENG | 2352-7102 | 35 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2021 | 7.144 | 6.2 | 6.23 | 2025-07-30 | 69 | 85 | HVAC systems; Fault detection and diagnosis; Supervised auto-encoder; Air handling units; Data-driven model; Artificial neural network | INTELLIGENCE; NETWORKS; MODEL | Air handling units; Artificial neural network; Data-driven model; Fault detection and diagnosis; HVAC systems; Supervised auto-encoder | Air conditioning; Chemical detection; Failure analysis; HVAC; Air handling units; Air-handling unit; Data-driven approach; Energy wastages; Fault detection and diagnosis schemes; Indoor environment; Model-based OPC; Reconstruction error; Fault detection | English | 2021 | 2021-03 | 10.1016/j.jobe.2020.102111 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Mating Selection Based on Modified Strengthened Dominance Relation for NSGA-III | In multi/many-objective evolutionary algorithms (MOEAs), to alleviate the degraded convergence pressure of Pareto dominance with the increase in the number of objectives, numerous modified dominance relationships were proposed. Recently, the strengthened dominance relation (SDR) has been proposed, where the dominance area of a solution is determined by convergence degree and niche size (theta over bar ). Later, in controlled SDR (CSDR), theta over bar and an additional parameter (k) associated with the convergence degree are dynamically adjusted depending on the iteration count. Depending on the problem characteristics and the distribution of the current population, different situations require different values of k, rendering the linear reduction of k based on the generation count ineffective. This is because a particular value of k is expected to bias the dominance relationship towards a particular region on the Pareto front (PF). In addition, due to the same reason, using SDR or CSDR in the environmental selection cannot preserve the diversity of solutions required to cover the entire PF. Therefore, we propose an MOEA, referred to as NSGA-III*, where (1) a modified SDR (MSDR)-based mating selection with an adaptive ensemble of parameter k would prioritize parents from specific sections of the PF depending on k, and (2) the traditional weight vector and non-dominated sorting-based environmental selection of NSGA-III would protect the solutions corresponding to the entire PF. The performance of NSGA-III* is favourably compared with state-of-the-art MOEAs on DTLZ and WFG test suites with up to 10 objectives. | Dutta, Saykat; Raju, Sri Srinivasa M.; Mallipeddi, Rammohan; Das, Kedar Nath; Lee, Dong-Gyu | Natl Inst Technol Silchar, Dept Math, Silchar 788010, Assam, India; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu 41566, South Korea | M, Sri Srinivasa Raju/GNH-4935-2022; Mallipeddi, Rammohan/AAL-5306-2020; Dutta, Saykat/ABE-3044-2021; dutta, saykat/ABE-3044-2021 | 57204580655; 57339126800; 25639919900; 55220472200; 57169003900 | saykat_rs@math.nits.ac.in;m._rs@math.nits.ac.in;mallipeddi@knu.ac.kr;kedarnath@math.nits.ac.in;dglee@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 22 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.45 | 2025-07-30 | 4 | 3 | convergence; decomposition; diversity; dominance; ensemble | EVOLUTIONARY ALGORITHM; DECOMPOSITION; CONVERGENCE; OPTIMALITY; DIVERSITY; AREA | Convergence; Decomposition; Diversity; Dominance; Ensemble | English | 2021 | 2021-11 | 10.3390/math9222837 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | A Modified Recursive Regularization Factor Calculation for Sparse RLS Algorithm with l1-Norm | In this paper, we propose a new calculation method for the regularization factor in sparse recursive least squares (SRLS) with l(1)-norm penalty. The proposed regularization factor requires no prior knowledge of the actual system impulse response, and it also reduces computational complexity by about half. In the simulation, we use Mean Square Deviation (MSD) to evaluate the performance of SRLS, using the proposed regularization factor. The simulation results demonstrate that SRLS using the proposed regularization factor calculation shows a difference of less than 2 dB in MSD from SRLS, using the conventional regularization factor with a true system impulse response. Therefore, it is confirmed that the performance of the proposed method is very similar to that of the existing method, even with half the computational complexity. | Lim, Junseok; Lee, Keunhwa; Lee, Seokjin | Sejong Univ, Dept Elect Engn, Coll Elect & Informat Engn, Seoul 05006, South Korea; Sejong Univ, Dept Def Syst Engn, Coll Engn, Seoul 05006, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Sch Elect & Elect Engn, Coll IT Engn, Daegu 41566, South Korea | 7403454336; 57188693039; 36174416200 | jslim@sejong.ac.kr;nasalkh2@sejong.ac.kr;sjlee6@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 13 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.55 | 2025-07-30 | 3 | 4 | sparse impulse response system; sparse system estimation; l(1)-RLS; regularization factor | SYSTEMS; SIGNALS | L<sub>1</sub>-RLS; Regularization factor; Sparse impulse response system; Sparse system estimation | English | 2021 | 2021-07 | 10.3390/math9131580 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | A non-Bayesian nonparametric model for characterization of basin-scale aquifers using groundwater level fluctuations | In this study, a non-Bayesian nonparametric model for characterization of the hydraulic properties of a basin-scale aquifer is proposed based on the natural stimulus of recharge from precipitation via a geostatistical principal component adaptation evolution strategy. We modified an existing model to use a low-dimensional projection onto the principal component space as well as improve computational efficiency and memory requirements. To illustrate the scalability of the proposed model, we estimated about 10 million unknown hydraulic conductivities (HCs), which required only 35 min or less on a modern workstation. To test the estimation accuracy, the proposed model was employed to estimate several aquifer HC fields using timeseries data of groundwater levels of more than 60 days at 16 monitoring wells with the recharge rate provided. Two cases were considered-when HC measurements at the monitoring wells were available and unavailable. In addition, inversions were performed using perfectly known and erroneous recharge rates. Using various test configurations, we found that the estimation was better when HC measurements at the monitoring wells were available. For inaccurately determined recharge rates, the estimation accuracy generally deteriorated, but the structural features of the estimated HC fields were similar to those obtained using the correctly assigned recharge rate. Regardless of the availability of HC measurements at the monitoring wells, the proposed model estimated the distribution of HC reasonably well, even when incorrect prior statistics of the mean and correlation scales were provided. By demonstrating that an aquifer can be characterized at the basin-scale using recharge from precipitation, the relevance of the proposed model, which had high computational efficiency, was evident. | Park, Eungyu; Lee, Jonghyun | Kyungpook Natl Univ, Dept Geol, 80 Daehak Ro, Daegu 41566, South Korea; Univ Hawaii Manoa, Dept Civil & Environm Engn, Honolulu, HI 96822 USA; Univ Hawaii Manoa, Water Resources Res Ctr, Honolulu, HI 96822 USA | 23995577700; 54911744000 | egpark@knu.ac.kr; | JOURNAL OF HYDROLOGY | J HYDROL | 0022-1694 | 1879-2707 | 602 | SCIE | ENGINEERING, CIVIL;GEOSCIENCES, MULTIDISCIPLINARY;WATER RESOURCES | 2021 | 6.708 | 6.2 | 0.17 | 2025-07-30 | 0 | 4 | Basin-scale; Aquifer characterization; Natural stimuli; Recharge rate; Evolution strategy; Geostatistics; Principal components | COMPONENT GEOSTATISTICAL APPROACH; HYDRAULIC TOMOGRAPHY; WATER; HEAD; EVOLUTION; INVERSION | Aquifer characterization; Basin-scale; Evolution strategy; Geostatistics; Natural stimuli; Principal components; Recharge rate | Aquifers; Efficiency; Groundwater resources; Hydraulic conductivity; Hydrogeology; Monitoring; Recharging (underground waters); Wells; Aquifer characterization; Basin scale; Bayesian nonparametric modeling; Conductivity measurements; Evolution strategies; Geo-statistics; Monitoring wells; Natural stimulus; Principal Components; Recharge rates; aquifer; groundwater; hydraulic property; hydrogeology; hydrological modeling; precipitation (climatology); recharge; Computational efficiency | English | 2021 | 2021-11 | 10.1016/j.jhydrol.2021.126710 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Age-Specific Mathematical Model for Tuberculosis Transmission Dynamics in South Korea | Korea has the highest burden of tuberculosis (TB) among Organization for Economic Co-operation and Development countries. Various strategies have been implemented to eradicate TB in Korea, and it is critical to evaluate previous TB management outcomes before framing future TB policies. Over the past few decades, the rapid increase in the aging population in Korea has substantially impacted the incidence of TB among the elderly. Thus, in this study, we aimed to develop a mathematical model for the assessment of TB management outcomes incorporating special features of TB transmission dynamics in Korea. First, we incorporate 2-age groups in our TB model because TB epidemics in Korea are different between the elderly and the non-elderly (= 65 years). Second, because the public-private mix has had a full-fledged impact since 2012, this study was divided into two periods (2001-2011 and 2012-2018). We developed a mathematical model of TB transmission dynamics with 2-age groups and age-specific model parameters were estimated based on actual TB epidemic data from 2001 to 2018. These parameters included transmission rates, relapse rates, and recovery rates. We conducted sensitivity analyses of various parameters, and investigated the impacts of these parameters on TB incidence. Our results demonstrate that the overall outcomes of both age-groups improved in the period of 2012-2018 compared with that in the period of 2001-2011. Age-specific interventions should be implemented to reduce the overall TB incidence. More intensive treatment efforts should be focused on the elderly, while the early detection and treatment rates for latent TB were the most significant factor to reduce TB incidence in both groups. | Lee, Sunmi; Park, Hae-Young; Ryu, Hohyung; Kwon, Jin-Won | Kyung Hee Univ, Dept Appl Math, Yongin 17104, South Korea; Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Coll Pharm, Pharmaceut Sci Res Inst, Daegu 41566, South Korea | 55716483800; 57203771734; 57218586326; 16202951700 | sunmilee@khu.ac.kr;hypark0303@gmail.com;rootfna@khu.ac.kr;jwkwon@knu.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 8 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.82 | 2025-07-30 | 7 | 9 | TB mathematical model with two-age groups; transmission rate; treatment rate; early detection and treatment rate; relapse rate; the basic reproduction number; various interventions (public-private mix) | LATENT TUBERCULOSIS; RISK | Early detection and treatment rate; Relapse rate; TB mathematical model with two-age groups; The basic reproduction number; Transmission rate; Treatment rate; Various interventions (public-private mix) | English | 2021 | 2021-04 | 10.3390/math9080804 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Efficient Processing of All Nearest Neighbor Queries in Dynamic Road Networks | The increasing trend of GPS-enabled smartphones has led to the tremendous usage of Location-Based Service applications. In the past few years, a significant amount of studies have been conducted to process All nearest neighbor (ANN) queries. An ANN query on a road network extracts and returns all the closest data objects for all query objects. Most of the existing studies on ANN queries are performed either in Euclidean space or static road networks. Moreover, combining the nearest neighbor query and join operation is an expensive procedure because it requires computing the distance between each pair of query objects and data objects. This study considers the problem of processing the ANN queries on a dynamic road network where the weight, i.e., the traveling distance and time varies due to various traffic conditions. To address this problem, a shared execution-based approach called standard clustered loop (SCL) is proposed that allows efficient processing of ANN queries on a dynamic road network. The key concept behind the shared execution technique is to exploit the coherence property of road networks by clustering objects that share common paths and processing the cluster as a single path. In an empirical study, the SCL method achieves significantly better performance than competitive methods and efficiently reduces the computational cost to process ANN queries in various problem settings. | Bhandari, Aavash; Hasanov, Aziz; Attique, Muhammad; Cho, Hyung-Ju; Chung, Tae-Sun | Ajou Univ, Dept Artificial Intelligence, Suwon 16499, South Korea; Ajou Univ, Dept Comp Engn, Suwon 16499, South Korea; Sejong Univ, Dept Software, Seoul 05006, South Korea; Kyungpook Natl Univ, Dept Software, Sangju 37224, South Korea | ; Hasanov, Aziz/LCD-3604-2024 | 57224088168; 57194875946; 55755354900; 55177091600; 21033702700 | aavashbhandari@ajou.ac.kr;aziz.hasanov.kh@gmail.com;mattique@gmail.com;hyungju@knu.ac.kr;tschung@ajou.ac.kr; | MATHEMATICS | MATHEMATICS-BASEL | 2227-7390 | 9 | 10 | SCIE | MATHEMATICS | 2021 | 2.592 | 6.2 | 0.45 | 2025-07-30 | 1 | 2 | all nearest neighbor queries; spatial query processing; spatial road networks; shared execution; graph algorithms | SAFE EXIT ALGORITHM; SNAPSHOT | All nearest neighbor queries; Graph algorithms; Shared execution; Spatial query processing; Spatial road networks | English | 2021 | 2021-05 | 10.3390/math9101137 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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