2025 연구성과 (25 / 151)

※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
Article Proactive Drug Monitoring Versus Clinically Based Dosing for Endoscopic Healing in Pediatric Crohn's Disease Receiving Infliximab Background & Aims: Proactive dosing based on therapeutic drug monitoring (TDM) of adalimumab is associated with higher rates of sustained corticosteroid-free clinical remission (SCFCR) in children with Crohn's disease (CD) than that with reactive TDM. We aimed to investigate whether proactive dosing of infliximab (IFX) based on TDM is associated with higher rates of endoscopic healing (EH) in pediatric patients with CD than that with clinically based dosing. Methods: We conducted a non-blinded, randomized controlled trial of 112 biologic-naïve children with CD who had responded to IFX induction treatment at 4 centers in South Korea between July 2017 and November 2020. Patients were randomly assigned to receive dosing based on proactive TDM (proactive arm) or clinically based dosing (clinical arm). The primary endpoint was EH at week 54. Results: The primary endpoint was achieved in 80.0% (40/50) of the proactive arm and 57.1% (28/49) of the clinical arm (P = .025). SCFCR was achieved in 69.6% (39/56) of the clinical arm and 89.3% (50/56) of the proactive arm at week 54 of treatment (P = .019). According to the multivariate logistic regression analysis, the intervention group (proactive arm vs clinical arm) was an independent factor associated with EH (odds ratio, 3.48; 95% confidence interval, 1.26–10.43; P = .019) and SCFCR (odds ratio, 5.50; 95% confidence interval, 1.72–21.61; P = .007). Conclusions: Dosing based on proactive TDM was superior to clinically based dosing in terms of EH in a randomized controlled trial of pediatric CD. Trial identifier: cris.nih.go.kr: KCT0005190 © 2025 The Author(s) Kang, Ben; Kim, Eun Sil; Choi, Sujin; Choe, Byung-Ho; Moon, Jin Soo; Ko, Jae Sung; Sohn, Sangjun; Lee, Yeoun Joo; Kwon, Yiyoung; Kim, Mi Jin; Jeon, Tae Yeon; Lee, So Mi; Lee, Seunghyun; Ju, Youngcheol; Choe, Yon Ho Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Pusan National University Yangsan Hospital, College of Medicine, Pusan National University, Yangsan, South Korea; Department of Pediatrics, Pusan National University Yangsan Hospital, College of Medicine, Pusan National University, Yangsan, South Korea; Department of Pediatrics, School of Medicine, Inha University, Incheon, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Radiology, School of Medicine, Kyungpook National University, Daegu, South Korea; Department of Radiology, Seoul National University College of Medicine, Seoul, South Korea; Research and Development Department, Celltrion Pharm, Inc., Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea 57194823199; 57205500267; 57223972405; 57574977300; 25646123100; 16643216300; 58748811200; 59897969500; 57211905573; 56638815200; 59944824200; 59945394800; 57204432336; 59944532900; 59918607100 i101016@skku.edu; Clinical Gastroenterology and Hepatology CLIN GASTROENTEROL H 1542-3565 1542-7714 SCIE GASTROENTEROLOGY & HEPATOLOGY 2024 12 5.8 N/A 0 Crohn's Disease; Infliximab; Pediatric; Proactive Dosing; Therapeutic Drug Monitoring English Article in press 2025 10.1016/j.cgh.2025.04.025 바로가기 바로가기 바로가기
Article Seeds for gut health: Prebiotic potential of seed mucilages from Chia, Fenugreek, Basil, Mustard, and Flaxseed and their impact on adult and toddler's gut microbiome The present study investigated the effects of seed mucilage on the gut microbial community and its impact on toddler (young child; 6-24 month) and adult gut health. In this study, we extracted seed mucilages from selected seeds (chia, fenugreek, basil, mustard, and flaxseed) and examined their prebiotic properties via the amylase degradation assay and impact on the growth of various probiotic cultures (Bifidobacterium and Lactobacillus). The findings demonstrate that seed mucilages are rich in indigestible carbohydrates and can enhance probiotics. The effects of seed mucilages on gut communities were analyzed using an in vitro fecal fermentation model, followed by 16S rRNA sequencing and the assessment of produced short-chain fatty acids (SCFAs; butyrate, propionate, and acetate). Analysis of mucilage-treated samples revealed enhanced SCFA production, which is critical for gut health and systemic metabolic functions. Microbiome analysis indicated that seed mucilages significantly (p < 0.05) enhance the abundance of beneficial fiber degraders and SCFA producers, such as Lachnospiraceae ND3007, Lachnospiraceae NK4A136, and Butyricicoccus, while limiting pro-inflammatory Escherichia-Shigella. Among the seed mucilages, only mustard seed mucilage was found to enhance the probiotic Bifidobacterium in both adults and toddlers. Mucilage treatment also positively affected various metabolisms related to microbial growth and amino acid synthesis, which are also significantly correlated with mucilage-induced microbes. Fenugreek and mustard seed mucilages were observed to be distinctly effective in inhibiting microbes from the Proteobacteria phylum and Escherichia-Shigella genera. Overall, our study highlights the potential of seed mucilage as an effective prebiotic that improves gut microbiome composition and metabolic outcomes. Singh, Vineet; Mahra, Kanika; Klingate, Justina; Shin, Jae-Ho Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea Singh, Vineet/ABC-7000-2021 57211642447; 58998079500; 59740336200; 57224125922 singhvineet@knu.ac.kr; jhshin@knu.ac.kr; FUTURE FOODS FUTURE FOODS 2666-8335 11 ESCI FOOD SCIENCE & TECHNOLOGY 2024 8.2 5.8 0 2025-05-07 0 0 Seed mucilage; Prebiotic; SCFA; Probiotic; Toddler gut microbiome ACID; LIFE Prebiotic; Probiotic; SCFA; Seed mucilage; Toddler gut microbiome English 2025 2025-06 10.1016/j.fufo.2025.100628 바로가기 바로가기 바로가기 바로가기
Correction A comprehensive review on polylactic acid (PLA) - Synthesis, processing and application in food packaging( vol 234 , 123715 , 2023) Swetha, T. Angelin; Bora, Abhispa; Mohanrasu, K.; Balaji, P.; Raja, Rathinam; Ponnuchamy, Kumar; Muthusamy, Govarthanan; Arun, A. Alagappa Univ, Dept Microbiol, Bioenergy & Bioremediat Lab, Karaikkudi 630003, Tamil Nadu, India; MGR Coll, PG & Res Ctr Biotechnol, Hosur, Tamil Nadu, India; Sree Balaji Med Coll & Hosp SBMCH, Bharath Inst Higher Educ & Res BIHER, Res & Dev Wing, Chennai 600044, India; Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Saveetha Inst Med & Tech Sci, Dept Biomat, Saveetha Dent Coll & Hosp, Chennai 600077, India Arun, A./F-8986-2019; Paulraj, Balaji/G-3392-2012; Bora, Abhispa/LWI-6840-2024; Ponnuchamy, Kumar/D-3470-2013; Muthusamy, Govarthanan/C-1491-2014 57831801800; 57210557182; 57202300780; 56644888000; 16029399900; 58108465500; 54881927600; 57078221100 arunalacha@gmail.com; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 306 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-05-07 0 0 controlled study; erratum; human; therapy English 2025 2025-05 10.1016/j.ijbiomac.2025.141687 바로가기 바로가기 바로가기 바로가기
Article Activation of methoxy group of hardwood kraft lignin via cross-coupling and crosslinking for lignin-based wood adhesives The methoxy (-OCH3) group of hardwood kraft lignin (HKL) exhibits poor reactivity and limits its valorization due to its steric hindrance. Herein, we report an efficient activation of the-OCH3 group in a cross-coupling reaction, enabling its crosslinking for lignin-based wood adhesives. Specifically, the-OCH3 groups are replaced with an activated nucleophile, CH2-SiMe3, which is then successfully used for the subsequent cross-linking with either epichlorohydrin (ECH) or glyoxal (GLY) as crosslinkers. The new peaks in the FT-IR, 13C NMR, and 2D HSQC NMR spectra, and a decrease in methoxy group confirm the activation. Furthermore, the activated HKL exhibits a decrease in molecular weight and glass transition temperature. The successful crosslinking with ECH or GLY is demonstrated by an exothermic reaction by differential scanning calorimetry (DSC) and ether and acetal linkages formation by solid-state 13C NMR, respectively. Both unactivated and activated HKL-based adhesives are cured at hot-pressing temperatures for plywood. The activated HKL-based adhesives significantly improve adhesion strength, reaching a maximum value (2.61 MPa) compared to the unactivated HKL (2.18 MPa), exceeding the Korean standard requirement (0.60 MPa). These results suggest that methoxy group activation via cross-coupling effectively promotes HKL crosslinking for lignin-based wood adhesives. Watumlawar, Ega Cyntia; Park, Byung-Dae Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea Park, Byung-Dae/ABB-1934-2020 58097378800; 59874304100 byungdae@knu.ac.kr; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 315 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-06-11 0 0 Hardwood Kraft lignin; Crosslinking; Bio-based adhesives ACETONE FRACTIONATION; GLYOXAL; PERFORMANCE; POLYESTERS; PROTEIN; RESIN; FTIR Bio-based adhesives; Crosslinking; Hardwood Kraft lignin Activation; Adhesives; Epichlorohydrin; Glyoxal; Hardwoods; Lignins; Nuclear Magnetic Resonance; Peeling; Crosslinking; Fourier transform infrared spectroscopy; Glues; Peeling; adhesive agent; glyoxal; lignin; Bio-based; Bio-based adhesive; Cross-couplings; Epichlorohydrin; Glyoxal; Hardwood kraft; Hardwood kraft lignin; Kraft lignin; Methoxy group; Wood adhesives; Article; carbon nuclear magnetic resonance; chemical analysis; controlled study; cross coupling reaction; cross linking; differential scanning calorimetry; Fourier transform infrared spectroscopy; fractionation; gel permeation chromatography; glass transition temperature; molecular weight; nonhuman; nuclear magnetic resonance spectroscopy; proton nuclear magnetic resonance; shear strength; stereospecificity; temperature; thermogravimetry; wood; Hardwoods English 2025 2025-06 10.1016/j.ijbiomac.2025.144670 바로가기 바로가기 바로가기 바로가기
Article Archaeal tyrosinase as a versatile biocatalyst for lignin-derived aromatic compounds valorization Biomass-derived aromatic compounds, including those obtained from lignin (which is the most abundant aromatic biopolymer on Earth), are valuable for sustainable chemical production. Various lignin-degrading approaches have been developed to cleave recalcitrant bonds. The incorporation of biocatalysts that operate under environmentally friendly and mild conditions with high substrate specificity is considered one of the emerging strategies for lignin valorization. In this study, an archaeal tyrosinase (Tyr-CNK), derived from the marine archaeon Candidatus nitrosopumilus koreensis, is characterized as a versatile biocatalyst for lignin biodegradation and valorization, based on kinetic studies, protein structure determination, and analysis. Notably, the extremely shallow active site pocket and the unique noncanonical caddy domain, which facilitate efficient copper incorporation without obstructing the active site, collectively empower Tyr-CNK with remarkable catalytic efficiency toward various lignin model compounds, such as p-coumaric acid, 4-phenoxyphenol, 4-(benzyloxy)phenol, and guaiacyl glycerol-(3-guaiacyl ether. Together with molecular docking simulations, these catalytic and structural features indicate that Tyr-CNK serves as an efficient biocatalyst for the hydroxylation and oxidative degradation of lignin-derived phenolic compounds. Given its versatility, efficiency, and structural uniqueness, Tyr-CNK demonstrates great promise for expanding the catalytic repertoire for biomass conversions and offering new opportunities in sustainable biocatalysis, enzymatic and microbial biodegradation and biomass valorization. Lee, Seul Hoo; Kang, Eungsu; Choi, Yoo Seong; Kim, Kyung-Jin Kyungpook Natl Univ, Sch Life Sci, KNU Creat Biores Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; Chungnam Natl Univ, Dept Chem Engn & Appl Chem, Daejeon 34134, South Korea 57205261937; 57200791110; 59697423600; 55510867400 biochoi@cnu.ac.kr; kkim@knu.ac.kr; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 316 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-06-11 0 0 Archaeal tyrosinase; Aromatic compound valorization; Lignin model compounds; Hydroxylation; Oxidative degradation BACTERIAL TYROSINASES; LACCASE; COPPER; PEROXIDASE; OXIDASES; ENZYMES; ACID Archaeal tyrosinase; Aromatic compound valorization; Hydroxylation; Lignin model compounds; Oxidative degradation Aromatic Compounds; Biodegradation; Biomass; Copper; Efficiency; Hydroxylation; Lignin Model Compounds; Phenols; Archaea; Biocatalysis; Catalytic Domain; Kinetics; Lignin; Molecular Docking Simulation; Monophenol Monooxygenase; Substrate Specificity; Aromatic hydrocarbons; Aromatization; Phenols; archaeal protein; aromatic compound; biopolymer; lignin; monophenol monooxygenase; lignin; monophenol monooxygenase; Archaeal; Archaeal tyrosinase; Aromatic compound valorization; Chemical production; Condition; Guaiacyl; Lignin models compounds; Oxidative degradation; Substrate specificity; Valorisation; affinity chromatography; archaeon; Article; bacterium; biocatalyst; biodegradation; biomass; Candidatus nitrosopumilus koreensis; crystal structure; DNA sequence; Escherichia coli; flow rate; high performance liquid chromatography; hydroxylation; kinetics; molecular docking; nonhuman; oxidation; pH; polyacrylamide gel electrophoresis; polymerase chain reaction; protein expression; protein purification; protein structure; simulation; site directed mutagenesis; size exclusion chromatography; valorization; biocatalysis; chemistry; enzyme active site; enzyme specificity; enzymology; metabolism; Hydroxylation English 2025 2025-06 10.1016/j.ijbiomac.2025.144669 바로가기 바로가기 바로가기 바로가기
Article Bio-crosslinking of oxidized hardwood kraft lignin as fully bio-based adhesives for wood bonding Lignin's low reactivity and crosslinking challenges limit its applications. To address this, many synthetic cross-linkers have been used, but they often involve hazardous chemicals, raising environmental concerns. In particular, it is also true for hardwood kraft lignin (HKL) being burned or wasted in kraft pulping mills. This study reports the successful chitosan bio-crosslinking of oxidized HKL with sodium periodate rather than toxic and environmentally harmful crosslinkers. Both low oxidation (LO) and high oxidation (HO) levels enhance the reactivity of HKL by introducing aldehyde groups, thereby facilitating the formation of imine and amide bonds with chitosan, leading to higher glass transition temperature (Tg), higher viscosity, and greater adhesion strength. The results indicate that the crosslinking of acetone soluble HKL (ASHKL) at LO level with chitosan exhibits excellent dry adhesion strength (1.15 +/- 0.2 MPa) for plywood, which meet the required adhesion level of Korean Standard (0.6 MPa) and European Norm 314-2 (1 MPa). These results reveal that chitosan is an outstanding polysaccharide-based crosslinker for the bio-crosslinking of HKL owing to its sustainability, biocompatibility, functional properties, and capability to form covalent bonds. Ghahri, Saman; Park, Byung-Dae Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea Ghahri, Saman/J-6213-2019; Park, Byung-Dae/ABB-1934-2020 53063443000; 7402834820 byungdae@knu.ac.kr; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 309 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-05-07 0 1 Kraft lignin; Bio-crosslinker; Bio-based adhesive OXIDATION; PERIODATE Bio-based adhesive; Bio-crosslinker; Kraft lignin Adhesion; Chitosan; Hardwoods; Kraft Pulping; Lignins; Oxidation; Reactivity; Wood Products; Adhesives; Chitosan; Cross-Linking Reagents; Lignin; Oxidation-Reduction; Viscosity; Wood; Chitosan; Crosslinking; Glass bonding; Kraft pulp; Wood chemicals; Wood products; adhesive agent; biobased adhesive; chitosan; imine; lignin; oxidized hardwood kraft lignin; periodate sodium; polysaccharide; unclassified drug; cross linking reagent; Kraft lignin; Adhesives for wood; Bio-based; Bio-based adhesive; Bio-crosslinker; Crosslinker; Hardwood kraft; ITS applications; Kraft lignin; Oxidation level; Wood bonding; acidification; Article; biocompatibility; carbon nuclear magnetic resonance; chemical composition; chemical structure; covalent bond; cross linking; decomposition; differential scanning calorimetry; dispersity; Fourier transform infrared spectroscopy; glass transition temperature; greater adhesion strength; hydrogen bond; nuclear magnetic resonance spectroscopy; oxidation; pH; room temperature; strength; tensile strength; viscosity; wood; wood bonding; X ray photoemission spectroscopy; chemistry; oxidation reduction reaction; Hardwoods English 2025 2025-05 10.1016/j.ijbiomac.2025.142907 바로가기 바로가기 바로가기 바로가기
Article Demographic influences on urban commercial spaces: Spatial characteristics and purchase patterns across age groups in Incheon, Korea This study investigates the spatial characteristics of age-specific purchase areas in Incheon, South Korea, to address the challenges of demographic aging and community decline. Using credit card transaction data and urban spatial data, we analysed purchase patterns and identified main purchase areas by age group, examining their urban spatial characteristics in relation to various physical factors. As a result of the analysis, young adults' purchase patterns are characterized by convenience stores and restaurants, with their main purchase area featuring quick pedestrian access to daily facilities despite relatively low provision of rest facilities. Middle-aged adults show diverse business-type and family-oriented facility purchases, with their area characterized by mixeduse and vehicle-oriented environments. Older adults demonstrate purchase patterns focused on health promotion and hobby activities, with their main purchase area exhibiting balanced characteristics for both pedestrian and vehicular use. Senior adults show a high proportion of purchases in groceries and health-related items, with their area featuring pedestrian-friendly environment and excellent accessibility to essential facilities. This study's significance lies in its use of credit card transaction data to objectively analyse actual usage patterns and accurately identify concentrated purchase areas, complementing the limitations of survey-based methods. Furthermore, by examining how physical factors affecting purchase activities are reflected in the spatial configuration of active purchasing areas, this research provides empirical evidence for developing age-responsive urban planning strategies. The findings serve as valuable insights for creating inclusive and efficient urban environments that consider age-specific characteristics, thereby potentially improving community vitality. Han, Hyeyoung; Choi, Jeongyoon; Lee, Jae Hyun Incheon Natl Univ, Dept Architecture, Incheon 22012, South Korea; Incheon Natl Univ, Sch Architecture & Urban Design, Incheon 22012, South Korea; Kyungpook Natl Univ, Dept Geog, Daegu 41566, South Korea 58915312600; 58915071300; 57189870403 jychoi@inu.ac.kr; CITIES CITIES 0264-2751 1873-6084 160 SSCI URBAN STUDIES 2024 6.6 5.9 0 2025-05-07 0 0 Local community vitalization; Purchase patterns; Urban spatial characteristics; Incheon SERVICE; LEVEL Incheon; Local community vitalization; Purchase patterns; Urban spatial characteristics Incheon [South Korea]; South Korea; accessibility; commercialization; consumption behavior; health expenditure; pedestrianization; recreational activity; retailing; spatial planning; urban planning English 2025 2025-05 10.1016/j.cities.2025.105843 바로가기 바로가기 바로가기 바로가기
Article Development of soft food gels from high-methyl pectin-protein conjugates via acid- and heat-induced crosslinking for dysphagia-friendly applications This study developed pea protein isolate (PPI)–high-methyl (HM) pectin conjugates via the Maillard reaction to enhance PPI's functionality as a texture modifier for dysphagia-friendly soft food gels. Conjugation at 1:1, 2:1, and 4:1 protein-to-pectin ratios significantly improved structural flexibility, physicochemical characteristics, and functional properties. Fourier Transform Infrared Spectroscopy (FT-IR) confirmed successful conjugation through shifts in amide I and II bands, while SDS-PAGE revealed higher molecular weight aggregates, indicating effective crosslinking. Circular Dichroism (CD) spectroscopy showed a reduction in β-sheet content (from 47.41 % to 16.15 %) and an increase in α-helices (from 0 % to 12.70 %), enhancing solubility (from 1.79 % to 100 %) and reducing surface hydrophobicity (from 74.52 % to 18.16 %). These structural changes facilitated improved protein dispersion and stable gel network formation, enhancing gel cohesiveness and softness, key attributes for dysphagia-friendly textures. Conjugate-incorporated gels exhibited softer textures than firmer control gels. Acid-induced gels formed soft, easily deformable matrices, while heat-induced gels produced firmer structures, accommodating different dysphagia severity levels. International Dysphagia Diet Standardization Initiative (IDDSI) assessments classified these gels as Level 6, ensuring safe swallowing. Rheological analyses revealed non-Newtonian shear-thinning behavior, while SAXS confirmed uniform nano-aggregation. Overall, PPI-HM pectin conjugates demonstrate potential as safe, functional solutions for texture-modified foods targeting dysphagia management. © 2025 Elsevier B.V. Said, Nurul Saadah; Lee, Won-Young School of Food Science and Technology, Kyungpook National University, Daegu, 702-701, South Korea; School of Food Science and Technology, Kyungpook National University, Daegu, 702-701, South Korea, Research Institute of Tailored Food Technology, Kyungpook National University, Daegu, 41566, South Korea 57211398275; 57195940408 wonyoung@knu.ac.kr; International Journal of Biological Macromolecules INT J BIOL MACROMOL 0141-8130 1879-0003 307 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-05-07 0 Dysphagia-friendly foods; Protein-polysaccharide conjugation; Soft food gels Deglutition Disorders; Gels; Hot Temperature; Pea Proteins; Pectins; Rheology; Solubility; Spectroscopy, Fourier Transform Infrared; Circular dichroism spectroscopy; Fourier transform infrared spectroscopy; Gels; Shear thinning; ammonium persulfate; antioxidant; bromophenol blue; carbonyl derivative; citric acid; gel; hydrochloric acid; hydroxyl group; monosaccharide; pectin; phthalaldehyde; polysaccharide; unclassified drug; gel; pea protein; Characteristic properties; Dysphagia-friendly food; Heat-induced crosslinking; Maillard reaction; Pea protein isolates; Physicochemical characteristics; Protein conjugates; Protein-polysaccharide conjugation; Soft food gel; Structural flexibilities; ABTS radical scavenging assay; antioxidant activity; Article; behavior; circular dichroism; cross linking; dispersion; dysphagia; dysphagia diet standardization initiative; Fourier transform infrared spectroscopy; hardness; heat; hydrophobicity; mastication; molecular weight; oil holding capacity; pea protein isolate; pH; physical chemistry; polyacrylamide gel electrophoresis; protein secondary structure; swallowing; temperature; turbidity; vulnerable population; water holding content; X ray crystallography; chemistry; flow kinetics; high temperature; solubility; Crosslinking English Final 2025 10.1016/j.ijbiomac.2025.142139 바로가기 바로가기 바로가기
Article Dynamic Adaptive Event-Triggered Mechanism for Fractional-Order Nonlinear Multi-Agent Systems with Actuator Saturation and External Disturbances: Application to Synchronous Generators This paper presents a novel dynamic adaptive event-triggered mechanism (DAETM) for addressing actuator saturation in leader-follower fractional-order nonlinear multi-agent networked systems (FONMANSs). By utilizing a sector-bounded condition approach and a convex hull representation technique, the proposed method effectively addresses the effects of actuator saturation. This results in less conservative linear matrix inequality (LMI) criteria, guaranteeing asymptotic consensus among agents within the FONMANS framework. The proposed sufficient conditions are computationally efficient, requiring only simple LMI solutions. The effectiveness of the approach is validated through practical applications, such as synchronous generators within a FONMANS framework, where it demonstrates superior performance and robustness. Additionally, comparative studies with Chua's circuit system enhance the robustness and efficiency of control systems compared to existing techniques. These findings highlight the method's potential for broad application across various multi-agent systems, particularly in scenarios with limited communication and actuator constraints. The proposed approach enhances system performance and provides a robust, adaptive control solution for dynamic and uncertain environments. Narayanan, G.; Baskar, M.; Gokulakrishnan, V.; Ahn, Sangtae Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Chennai Inst Technol, Ctr Computat Modeling, Chennai 600009, Tamil Nadu, India ; Ahn, Sangtae/AFQ-7342-2022 59089591800; 57188738884; 57209983740; 55468016100 narayananknu@knu.ac.kr; baskarm.ccm@citchennai.net; gokulakrishnanv@citchennai.net; stahn@knu.ac.kr; MATHEMATICS MATHEMATICS-BASEL 2227-7390 13 3 SCIE MATHEMATICS 2024 2.2 5.9 0 2025-05-07 0 0 fractional order; multi-agent systems; event-triggered mechanism; actuator saturation; synchronous generators CONSENSUS; SYNCHRONIZATION; DESIGN actuator saturation; event-triggered mechanism; fractional order; multi-agent systems; synchronous generators English 2025 2025-02 10.3390/math13030524 바로가기 바로가기 바로가기 바로가기
Article Effect of transverse versus midline periumbilical incision on incisional hernia and short-term outcomes after laparoscopic colon cancer surgery: multicentre, open-label, randomized clinical trial Background This study aimed to assess the effect of a periumbilical transverse incision compared with a periumbilical midline incision in reducing incisional hernia and improving short-term outcomes after laparoscopic colon cancer surgery.Methods This multicentre, open-label, randomized clinical trial was conducted at four high-volume hospitals in Korea, between April 2021 and February 2023. Patients were eligible if they were aged >= 20 years and had pathologically confirmed colon cancer. Block randomization was undertaken in a 1 : 1 ratio to transverse versus midline groups, stratified by tumour location. The primary endpoint was the incidence of radiological incisional hernia at 12 months after surgery. The secondary endpoints included symptomatic incisional hernia and short-term outcomes such as outcomes during surgery, complications at 30 days after surgery, pain after surgery, hospital stay after surgery, and patient-reported questionnaires.Results Of 174 enrolled patients, 155 were analysed for primary outcome (79 in transverse group and 76 in midline group). Radiological incisional hernia was significantly less frequent in the transverse group (6%) compared with the midline group (18%) 12 months after surgery (P = 0.022); however, there was no significant difference in the incidence of symptomatic incisional hernia between the two groups (3 versus 8%; P = 0.162). Surgical outcomes, complications after surgery, pain, and length of hospital stay did not differ significantly between the two groups. The transverse group had a shorter incision length (mean(standard deviation) 5.0(0.8) versus 5.3(0.8) cm; P = 0.027) and higher cosmesis score (18.0(3.2) versus 16.6(2.7); P = 0.006) than the midline group.Conclusion A periumbilical transverse incision significantly reduced radiological incisional hernia compared with a midline incision in laparoscopic colon cancer surgery. Clinical Research Information Service registration number: KCT0006082 (https://cris.nih.go.kr). In this multicentre, randomized clinical trial involving 174 patients, the incidence of radiological incisional hernia after 12 months was significantly lower in the transverse incision group (6%) compared with the midline incision group (18%). A transverse periumbilical incision may reduce the risk of incisional hernia in laparoscopic colon cancer surgery. Lee, Soo Young; Park, Soo Yeun; Ha, Gi Won; Son, Gyung Mo; Yon, Dong Keon; Kim, Chang Hyun Chonnam Natl Univ, Hwasun Hosp & Med Sch, Dept Surg, Hwasun 58128, Jeonnam, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Dept Surg,Biomed Res Inst, Jeonju, South Korea; Pusan Natl Univ, Yangsan Hosp, Sch Med, Dept Surg, Yangsan, South Korea; Kyung Hee Univ, Med Ctr, Med Sci Res Inst, Ctr Digital Hlth,Coll Med, Seoul, South Korea Son, Gyung/W-2979-2019; Yon, Dong Keon/M-1264-2017; Kim, chang/F-6457-2013; Ha, Gi/W-2026-2019 59945491800; 59908460400; 59659024200; 59920399400; 57193675906; 59944770100; 59944911500; 59945491900; 35226761100; 55548203300; 57209556084; 57223615889; 55748167300 cksantiago8@gmail.com; BJS OPEN BJS OPEN 2474-9842 9 3 SCIE SURGERY 2024 4.5 5.9 N/A 0 0 QUALITY-OF-LIFE; ABDOMINAL-SURGERY; ASSISTED COLECTOMY; BODY-IMAGE; EXTRACTION; LAPAROTOMY; RESECTION; CLOSURE; SITE; CT Aged; Colectomy; Colonic Neoplasms; Female; Humans; Incisional Hernia; Laparoscopy; Length of Stay; Male; Middle Aged; Pain, Postoperative; Postoperative Complications; Republic of Korea; Treatment Outcome; Umbilicus; aged; Article; body mass; cancer staging; colon cancer; controlled study; female; hospitalization; human; incisional hernia; laparoscopic colectomy; laparoscopic colon cancer surgery; laparoscopic surgery; length of stay; lymph node dissection; major clinical study; male; midline periumbilical incision; minilaparotomy; monopolar electrocautery; multicenter study; outcome assessment; patient reported questionnaire; questionnaire; radiologist; randomized controlled trial; Short Form 12; short term outcome; surgical technique; transverse periumbilical incision; tumor volume; adverse event; clinical trial; colectomy; colon tumor; comparative study; epidemiology; etiology; laparoscopy; middle aged; postoperative complication; postoperative pain; prevention and control; procedures; South Korea; surgery; treatment outcome; umbilicus English 2025 2025-06 10.1093/bjsopen/zraf062 바로가기 바로가기 바로가기 바로가기
Article Enhanced Sliding Variable-Based Robust Adaptive Control for Canonical Nonlinear System with Unknown Dynamic and Control Gain This study presents an advanced Sliding Variable-Based Robust Adaptive Control (SVRAC) scheme designed for canonical nonlinear system with unknown dynamic and control gain functions. Leveraging neural network (NN) approximation, the proposed method simplifies control design by eliminating the need for traditional sliding mode control (SMC) components like equivalent and switching controls. SVRAC integrates three key elements: a feedback control term to stabilize system errors, a NN-based term to estimate and compensate for uncertainties, and a robustness adjustment term to maintain control integrity under dynamic variations. Theoretical validation through Lyapunov stability analysis confirms that the system errors are Semi-Globally Uniformly Ultimately Bounded (SGUUB), and the tracking error converges to a neighborhood of zero. Numerical and engineering simulations further demonstrate that SVRAC achieves superior tracking performance, robustness, and adaptability compared to conventional methods. This approach offers a streamlined yet effective solution for managing uncertainties in complex nonlinear systems, with potential applications across diverse engineering domains. Zhu, Jiahao; Veluvolu, Kalyana C. Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea Veluvolu, Kalyana/C-6366-2011; Veluvolu, Kalyana Chakravarthy/C-6366-2011 57426624100; 8703318200 zjh_consci@knu.ac.kr; veluvolu@ee.knu.ac.kr; MATHEMATICS MATHEMATICS-BASEL 2227-7390 13 6 SCIE MATHEMATICS 2024 2.2 5.9 0 2025-05-07 0 0 SVRAC; canonical nonlinear system; neural network (NN); SMC; Lyapunov stability analysis; 93-10 canonical nonlinear system; Lyapunov stability analysis; neural network (NN); SMC; SVRAC English 2025 2025-03-16 10.3390/math13060976 바로가기 바로가기 바로가기 바로가기
Review Exploring nanolignin as a sustainable biomacromolecule in polymer composites: Synthesis, characterization, and applications: A review Nanolignin is a biomacromolecule nanomaterial obtained from lignin, a natural plant polymer. It has attracted considerable attention as a potential nanofiller for polymer composites owing to its remarkable properties, such as biodegradability, antioxidant activity, and high specific surface area. However, the development of biological macromolecule nano lignin-based polymer composites faces several challenges, mainly due to the complex structure and poor chemical compatibility of lignin with most polymers. A comprehensive summary of the functionalization strategies and synthesis techniques for nanolignin is provided in this article. The morphological, structural, and thermal characterization of nanolignin is also reviewed. Furthermore, this review summarizes the recent progress of nanolignin and its composites prepared using various polymers, such as polyvinyl alcohol, poly (methyl methacrylate), polylactic acid, phenol formaldehyde, and natural rubber. This study concludes by outlining the possible uses of nanolignin-reinforced polymer composites and the potential opportunities and disadvantages of using nanolignin as a reinforcement in polymer composites for several value-added applications. Chutturi, Mahesh; Kelkar, Bhushan U.; Yadav, Sumit Manohar; Wibowo, Eko Setio; Bhuyar, Prakash; Naik, B. Praveen; Sinha, Arijit; Lee, Seng Hua Forest Coll & Res Inst, Dept Forest Prod & Utilizat, Hyderabad 502279, Telangana, India; Univ Malaya, Ctr Adv Mat, Kuala Lumpur 50603, Malaysia; Inst Wood Sci & Technol, Bangalore 560 003, India; Natl Res & Innovat Indonesia, Res Ctr Biomat, Cibinong 16911, Indonesia; Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea; Maejo Univ, Int Coll MJU IC, Chiang Mai 50290, Thailand; Oregon State Univ, Coll Forestry, Dept Wood Sci & Engn, Corvallis, OR 97331 USA; Univ Teknol MARA UiTM, Fac Appl Sci, Dept Wood Ind, Cawangan Pahang Kampus Jengka, Pahang 26400, Malaysia Kelkar, B U/HKV-2985-2023; Lee, Seng Hua/V-1016-2019; Yadav, Sumit/AAI-2108-2020; Wibowo, Eko/AAL-5888-2021; Bhuyar, Prakash/ABA-6143-2020 58028310300; 57196473067; 57191834292; 57214910272; 57211993473; 59550528800; 57203184231; 57191711306 b.kelkar1792@gmail.com; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 304 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 1.95 2025-05-07 1 1 Nanofiller; Nanolignin; Nanocomposites; Synthesis methods; Polymer composites LIGNIN-BASED NANOPARTICLES; PHENOL-FORMALDEHYDE RESIN; EMPTY FRUIT BUNCHES; POLYVINYL-ALCOHOL; DRUG-DELIVERY; PICKERING EMULSION; CONTROLLED-RELEASE; THERMAL-STABILITY; ORGANOSOLV LIGNIN; RUBBER COMPOSITES Nanocomposites; Nanofiller; Nanolignin; Polymer composites; Synthesis methods Composites; Formaldehyde; Natural Rubber; Polymers; Reinforcement; Review; Synthesis; Lignin; Nanocomposites; Nanostructures; Polymers; Polyvinyl Alcohol; Lignin; Reinforced plastics; formaldehyde; lignin; nanocomposite; nanofiller; nanomaterial; phenol; poly(methyl methacrylate); polylactic acid; polymer; polyvinyl alcohol; rubber; lignin; nanocomposite; Antioxidant activities; Biomacromolecule; High specific surface area; Nanofiller; Nanolignin; Natural plants; Plant polymers; Polymer composite; Property; Synthesis method; antioxidant activity; biodegradability; macromolecule; nonhuman; pharmaceutics; review; surface area; synthesis; Nanoclay English 2025 2025-04 10.1016/j.ijbiomac.2025.140881 바로가기 바로가기 바로가기 바로가기
Article Gallol-containing chitosan/hyaluronic acid composite hydrogel patches as wound sealing and dressing materials Recently, various adhesive materials have been developed for versatile biomedical applications owing to their rapid and strong adhesion to tissues in water-rich environments. One such example is gallol-containing chitosan (CHI-G), which contains multiple gallol and amine groups in its backbone. However, the practical application of CHI-G alone is limited owing to its intrinsic mechanical strength and undesirable immune responses. In this study, we developed Ca2+ ions- and hyaluronic acid-containing CHI-G (CHC) patches to prevent anastomotic leakage and accelerate wound healing. CHC hydrogel patches showed increased elastic modulus values (809.4 f 181.7 Pa) compared to that of CHI-G hydrogel patches (137.0 f 16.3 Pa). In addition, the bursting pressure (78.2 f 3.5 mmHg) of CHC hydrogel patch-applied porcine intestine was far higher than those of the control (4.13 f 0.4 mmHg) and HA groups (14.5 f 2.5 mmHg). CHC hydrogel patches showed suitable mechanical properties and biocompatibility for wound-sealing and dressing applications in water-rich environments. Notably, the CHC hydrogel patch-applied wound healing animal model exhibited a healing rate of over 90 % at 14 days post- surgery, notably higher than that of the control group (76 %). These findings suggest that CHC patches have considerable potential as effective wound dressings and sealing materials. Hyun, Da Han; Shin, Hyun Ho; Seog, David Jin Han; Jang, Hyeonha; Choi, Jemin; Yoon, Ghilsuk; Jin, Eun-Jung; Park, Jun Seok; Ryu, Ji Hyun Kyungpook Natl Univ, Grad Sch, Dept Biomed Sci, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu 41404, South Korea; Wonkwang Univ, Grad Sch JABA, Dept Biomed Mat Sci, Iksan 54538, South Korea; Kyungpook Natl Univ, Med Res Ctr, Sch Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41566, South Korea; Wonkwang Univ, Smart Convergence Mat Anal Ctr, Dept Carbon Convergence Engn, Dept Chem Engn, Iksan 54538, South Korea 58089142700; 57890302900; 58174646400; 57218761651; 59643569900; 57204691355; 34570037700; 35226761100; 57208277508 parkjs0802@knu.ac.kr; jhryu4816@wku.ac.kr; INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES INT J BIOL MACROMOL 0141-8130 1879-0003 306 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE 2024 8.5 5.9 0 2025-05-07 1 1 Gallol-containing chitosan; Hyaluronic acid; Adhesive material; Intestinal anastomosis; Wound dressing HYALURONIC-ACID; RISK-FACTORS; CHITOSAN; CATECHOL; ADHESIVE; CYTOTOXICITY; INFECTION; POLYMERS; ALGINATE; FIBRIN Adhesive material; Gallol-containing chitosan; Hyaluronic acid; Intestinal anastomosis; Wound dressing Animals; Bandages; Biocompatible Materials; Chitosan; Hyaluronic Acid; Hydrogels; Materials Testing; Swine; Wound Healing; Chitosan; Hyaluronic acid; adhesive agent; chitosan; hyaluronic acid; hydrogel; isoflurane; pyrogallol; biomaterial; chitosan; hydrogel; Adhesive materials; Amine groups; Biomedical applications; Composite hydrogels; Gallol-containing chitosan; Immune response; Intestinal anastomosis; Mechanical; Wound dressings; Wound healing; anastomosis; animal experiment; animal model; animal tissue; Article; biocompatibility; biopsy; CCD-18Co cell line; cell migration; centrifugation; controlled study; cytotoxicity; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; hematology; human; human cell; immunohistochemistry; intestine anastomosis; male; MTT assay; nonhuman; proton nuclear magnetic resonance; rat; ultraviolet visible spectroscopy; viscosity; wound care; wound healing; wound sealing; animal; bandage; chemistry; drug effect; materials testing; pig; wound healing; Biocompatibility English 2025 2025-05 10.1016/j.ijbiomac.2025.141115 바로가기 바로가기 바로가기 바로가기
Article Joint Transmit Power and Power-Splitting Optimization for SWIPT in D2D-Enabled Cellular Networks with Energy Cooperation In this paper, we propose a joint optimization scheme for a transmit power and power-splitting ratio in device-to-device (D2D)-enabled simultaneous wireless information and power transfer (SWIPT) cellular networks, considering energy signal transmission. This energy signal facilitates the energy cooperation between the D2D transmitter (DT) and the CU. Under the proposed scheme, the D2D rate is maximized while guaranteeing that the cellular user (CU) achieves the same performance as in scenarios without D2D communications. In order to solve the formulated nonconvex problem, we leverage the monotonically increasing property of logarithmic functions to transform it into an equivalent convex problem. As a result, we obtain the optimal solution in closed form. Also, the optimal D2D performance is analyzed, and useful insights into the performance improvements achievable through the proposed scheme are obtained. Numerical results demonstrate that the proposed scheme significantly outperforms the baseline scheme. Lim, Dong-Woo; Kang, Jae-Mo Changwon Natl Univ, Dept Informat & Commun Engn, Chang Won 51140, South Korea; Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea 55694295300; 56024930400 dwlim@changwon.ac.kr; jmkang@knu.ac.kr; MATHEMATICS MATHEMATICS-BASEL 2227-7390 13 3 SCIE MATHEMATICS 2024 2.2 5.9 0 2025-05-07 0 0 device-to-device (D2D) communication; simultaneous wireless information and power transfer (SWIPT); transmit power optimization; power-splitting ratio optimization RESOURCE-ALLOCATION; D2D COMMUNICATION; WIRELESS INFORMATION device-to-device (D2D) communication; power-splitting ratio optimization; simultaneous wireless information and power transfer (SWIPT); transmit power optimization English 2025 2025-02 10.3390/math13030389 바로가기 바로가기 바로가기 바로가기
Article Low-Light Image Enhancement for Driving Condition Recognition Through Multi-Band Images Fusion and Translation When objects are obscured by shadows or dim surroundings, image quality is improved by fusing near-infrared and visible-light images. At night, when visible and NIR lights are insufficient, long-wave infrared (LWIR) imaging can be utilized, necessitating the attachment of a visible-light sensor to an LWIR camera to simultaneously capture both LWIR and visible-light images. This camera configuration enables the acquisition of infrared images at various wavelengths depending on the time of day. To effectively fuse clear visible regions from the visible-light spectrum with those from the LWIR spectrum, a multi-band fusion method is proposed. The proposed fusion process subsequently combines detailed information from infrared and visible-light images, enhancing object visibility. Additionally, this process compensates for color differences in visible-light images, resulting in a natural and visually consistent output. The fused images are further enhanced using a night-to-day image translation module, which improves overall brightness and reduces noise. This night-to-day translation module is a trained CycleGAN-based module that adjusts object brightness in nighttime images to levels comparable to daytime images. The effectiveness and superiority of the proposed method are validated using image quality metrics. The proposed method significantly contributes to image enhancement, achieving the best average scores compared to other methods, with a BRISQUE of 30.426 and a PIQE of 22.186. This study improves the accuracy of human and object recognition in CCTV systems and provides a potential image-processing tool for autonomous vehicles. Son, Dong-Min; Lee, Sung-Hak Kyungpook Natl Univ, Sch Elect & Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea Son, Dong-Min/LZH-4025-2025 57216612214; 7601395661 forhollow@knu.ac.kr; shak2@ee.knu.ac.kr; MATHEMATICS MATHEMATICS-BASEL 2227-7390 13 9 SCIE MATHEMATICS 2024 2.2 5.9 0 2025-06-11 0 0 image processing; image-to-Image translation; image fusion; long-wave infrared TRANSFORM; ALGORITHM image fusion; image processing; image-to-Image translation; long-wave infrared English 2025 2025-04-25 10.3390/math13091418 바로가기 바로가기 바로가기 바로가기
페이지 이동: