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| ○ | ○ | Article | Molecular detection of Anaplasma phagocytophilum in field-collected Haemaphysalis larvae in the Republic of Korea | BackgroundAnaplasma spp., zoonotic tick-borne pathogens affecting livestock, companion animals, and humans, exhibits 15-18% seropositivity among hunting dogs in the Republic of Korea (South Korea). The dominant tick species in South Korea, Haemaphysalis longicornis, can transmit these pathogens to both humans and animals. Given the limited understanding of transovarial transmission of Anaplasma spp., our study aimed to assess the prevalence of questing larval ticks containing Anaplasma DNA. Additionally, we aimed to gather data for establishing a nationwide forecasting and alert system on seasonal variation of tick developmental stages and tick-borne zoonotic pathogens.MethodsFrom March to October 2021 and again from March to October 2022, we collected a total of 36,912 unfed, questing ticks of Haemaphysalis spp. from 149 sites in South Korea. Ticks were collected from herbaceous vegetation using the flagging method using a white flannel cloth. After species identification, one-third of collected ticks underwent analysis for Anaplasma DNA. Nymph ticks were pooled in groups of 1-10 and larvae in groups of 1-50, while adults were examined individually. Nested polymerase chain reaction (PCR) was performed to detect the genus Anaplasma by amplifying the 16S rRNA gene, followed by sequencing for species identification and phylogenetic analysis.ResultsOf the 36,912 questing ticks collected, 13,082 (35.4%) were identified as nymphs and adults of H. longicornis and 3850 (10.4%) as those of Haemaphysalis flava. The morphologically indistinguishable larval stage of Haemaphysalis spp. predominated, with 19,980 (54.1%) collected primarily from July to October. From the 939 tick pools, 24 pools (2.6%) tested positive for Anaplasma, with the larval stage exhibiting the highest number of positive pools (16, 1.7%). Phylogenetic analysis revealed that 21 of the 24 Anaplasma-positive pools contained A. phagocytophilum-specific genes, with 1 identified as Anaplasma sp. and the remaining 2 as A. bovis.ConclusionsOur study provides evidence of transovarial transmission of A. phagocytophilum in Haemaphysalis spp. larvae under field conditions, showing that the bacteria are transmitted from mother ticks to unengorged, questing larvae. Additionally, our findings contribute significant data for establishing a nationwide forecasting and alert system on seasonal variation of tick developmental stages and tick-borne zoonotic pathogens. | Ahn, Kyusung; Alkathiri, Badriah; Lee, Seung-Hun; Lee, Haeseung; Kwak, Dongmi; Cho, Yun Sang; Lee, Hyang-Sim; Youn, Soyoun; Yoo, Mi-Sun; Kim, Jaemyung; Shin, Sungshik | Chonnam Natl Univ, BIOREEDS Res Inst, Coll Vet Med, Gwangju 61186, South Korea; Chungbuk Natl Univ, Coll Vet Med, 1 Chungdae Ro, Cheongju 28644, South Korea; Kyungpook Natl Univ, Coll Vet Med, 80 Daehak Ro, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Dept Anim & Plant Hlth Res, Viral Dis Div, Gimcheon 39660, South Korea; Anim & Plant Quarantine Agcy, Dept Anim & Plant Hlth Res, Bacterial Dis Div, Parasit & Honeybee Dis Lab, Gimcheon 39660, South Korea; Chonnam Natl Univ, Coll Vet Med, Lab Parasitol, Gwangju 61186, South Korea | Cho, Yun Sang/ACA-6165-2022 | 36004623300; 57190979864; 57203394416; 57202497862; 7007148758; 16066666200; 35094118100; 57190743135; 57217039464; 56298631700; 7403646673 | sungshik@jnu.ac.kr; | PARASITES & VECTORS | PARASITE VECTOR | 1756-3305 | 18 | 1 | SCIE | PARASITOLOGY;TROPICAL MEDICINE | 2024 | 3.5 | 5.4 | 0 | 2025-05-07 | 0 | 0 | Haemaphysalis longicornis; Anaplasma phagocytophilum; Transovarial transmission; Larvae; Epidemiology; Tick-borne diseases | TICK SURVEILLANCE; EHRLICHIA-EQUI; NEW-YORK; HUMANS | Anaplasma phagocytophilum; Epidemiology; Haemaphysalis longicornis; Larvae; Tick-borne diseases; Transovarial transmission | Anaplasma phagocytophilum; Animals; DNA, Bacterial; Dogs; Female; Ixodidae; Larva; Nymph; Phylogeny; Polymerase Chain Reaction; Republic of Korea; RNA, Ribosomal, 16S; Seasons; RNA 16S; bacterial DNA; RNA 16S; Anaplasma phagocytophilum; Article; controlled study; diagnostic test accuracy study; DNA extraction; dog; forecasting; gene sequence; Haemaphysalis; Haemaphysalis longicornis; Human immunodeficiency virus infection; larva; livestock; nested polymerase chain reaction; nonhuman; nymph; phylogeny; polymerase chain reaction; South Korea; tick borne disease; transovarial transmission; vegetation; animal; epidemiology; female; genetics; growth, development and aging; isolation and purification; Ixodidae; larva; microbiology; season; South Korea | English | 2025 | 2025-02-21 | 10.1186/s13071-024-06649-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Real-time isolation of physiological tremor using recursive singular spectrum analysis and random vector functional link for surgical robotics | Hand-held robotic instruments enhance precision in microsurgery by mitigating physiological tremor in real time. Current tremor filtering algorithms in these instruments often employ nonlinear phase prefilters to isolate the tremor signal. However, these filters introduce phase distortion in the filtered tremor, compromising accuracy. Although improved variants of recursive singular spectrum analysis (RSSA) have addressed the issue of phase distortion, they still face challenges such as reduced generalization performance, large sample delays, and longer computational times. To address these issues, we integrate an accurate and fast random vector functional link (RVFL) with RSSA, referred to as RSSA-RVFL. The proposed approach consists of two main steps: estimation using RSSA and prediction with RVFL. Additionally, we introduce two moving window variants of RSSA-RVFL for real-time implementation. These variants significantly reduce computational costs while delivering the same performance. Experimental results on real tremor data show that our proposed approach achieves an average accuracy of 79.03%, surpassing the benchmark of 70.40%, with a nine-sample delay. | Rasheed, Asad; Kim, Jeonghong; Ang, Wei Tech; Veluvolu, Kalyana C. | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Comp Sci & Engn Dept, 80 Daehakro, Daegu 41566, South Korea; Nanyang Technol Univ, Sch Mech & Aerosp Engn, 50 Nanyang Ave N3-01a-01, Singapore 639798, Singapore; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | Ang, Wei/F-9299-2010; Veluvolu, Kalyana Chakravarthy/C-6366-2011; Veluvolu, Kalyana/C-6366-2011 | 57225336324; 55138548100; 16240990400; 8703318200 | asad.rasheed@knu.ac.kr; jhk@knu.ac.kr; wtang@ntu.edu.sg; veluvolu@ee.knu.ac.kr; | ISA TRANSACTIONS | ISA T | 0019-0578 | 1879-2022 | 158 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, MULTIDISCIPLINARY;INSTRUMENTS & INSTRUMENTATION | 2024 | 6.5 | 5.4 | 0 | 2025-05-07 | 0 | 0 | Voluntary motion; Recursive singular spectrum analysis; Random vector functional link; Direct links; Tremor motion; Hand-held robotic instruments; Microsurgery | FOURIER LINEAR COMBINER; HAND EYE ROBOT; MULTISTEP PREDICTION; LEARNING ALGORITHMS; MACHINE; SUPPRESSION; SYSTEM | Direct links; Hand-held robotic instruments; Microsurgery; Random vector functional link; Recursive singular spectrum analysis; Tremor motion; Voluntary motion | Algorithms; Humans; Microsurgery; Robotic Surgical Procedures; Robotics; Signal Processing, Computer-Assisted; Spectrum Analysis; Tremor; Nonlinear distortion; Nonlinear filtering; Robotic surgery; Surgical equipment; Direct links; Functional links; Hand-held robotic instrument; Microsurgery; Random vector functional link; Random vectors; Recursive singular spectrum analyze; Singular spectrum analysis; Tremor motion; Voluntary motion; algorithm; human; microsurgery; pathophysiology; procedures; robot assisted surgery; robotics; signal processing; spectroscopy; tremor; Spectrum analyzers | English | 2025 | 2025-03 | 10.1016/j.isatra.2024.12.040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Physics-informed neural fractional differential equations | This study introduces physics-informed neural fractional differential equations, a novel approach that integrates neural ODE, fractional calculus, and physics-informed machine learning to advance the modeling of dynamical systems. Traditional methods often struggle to capture intricate systems' long-range dependencies and memory effects. Physics-informed neural fractional differential equations address these challenges by incorporating the Caputo fractional derivative into neural networks, combining the flexibility of neural ODEs with the power of fractional calculus and physical laws. This integration enhances the accuracy and efficiency of modeling systems with complicated behaviors and nonlocal effects. We use the predictor-corrector method to solve fractional differential equations and the Adam optimization method to update neural network parameters. Numerical examples, including the Van der Pol equation, a spring-mass system, and CO2 emission modeling, show that physics-informed neural fractional differential equations outperform traditional methods in accuracy and computational efficiency. This research bridges the gap between fractional calculus and deep learning, providing a powerful tool for modeling and predicting intricate dynamical systems in various scientific and engineering fields. | Vellappandi, Madasamy; Lee, Sangmoon | Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea | Lee, Sangmoon/C-4502-2018 | 57226550675; 59510733500 | vellappandim@gmail.com; moony@knu.ac.kr; | APPLIED MATHEMATICAL MODELLING | APPL MATH MODEL | 0307-904X | 1872-8480 | 145 | SCIE | ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;MECHANICS | 2024 | 5.1 | 5.5 | 0 | 2025-05-07 | 1 | 1 | Caputo fractional derivatives; Fractional calculus; Fractional differential equations; Intricate systems; Long-range dependencies; Long-range memory; Machine-learning; Memory effects; Neural-networks; Power; Differentiation (calculus) | English | 2025 | 2025-09 | 10.1016/j.apm.2025.116127 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Transiently propagating crack tip fields in anisotropic functionally gradient materials | Crack tip fields of transiently propagating cracks along functionally gradient direction in anisotropic materials with having variations in elasticity and density are developed. The Laplace- transformed dynamic equilibrium equations with dilatation and distortion wave potentials are obtained using the complex variable method, and the higher order crack tip fields near the crack tip are obtained and the validity of the crack tip fields is confirmed. Next, the isochromatics (contours of maximum shear stress) and isopachics (contours of first stress invariant) for the transiently propagating cracks in anisotropic functionally gradient materials are created, and their transient characteristics are discussed. | Lee, Kwang Ho; Kim, Ji Sik | Kyungpook Natl Univ, Dept Automot Engn, 2559 Gyeongsangdearo, Sangju 37224, Kyeongbuk, South Korea; Kyungpook Natl Univ, IDRS, 2559 Gyeongsangdearo, Sangju 37224, Kyeongbuk, South Korea; Kyungpook Natl Univ, Dept Nano & Adv Mat Engn, 2559 Gyeongsangdearo, Sangju 37224, Kyeongbuk, South Korea | 56348794600; 16444690100 | khl@knu.ac.kr; jisikkim@knu.ac.kr; | APPLIED MATHEMATICAL MODELLING | APPL MATH MODEL | 0307-904X | 1872-8480 | 140 | SCIE | ENGINEERING, MULTIDISCIPLINARY;MATHEMATICS, INTERDISCIPLINARY APPLICATIONS;MECHANICS | 2024 | 5.1 | 5.5 | 0 | 2025-05-07 | 0 | 0 | Anisotropic functionally gradient materials; Orthotropic functionally gradient materials; Isotropic functionally gradient materials; Transiently propagating cracks; Higher order crack tip fields | DYNAMIC FRACTURE; GRADED MATERIALS; STRESS; INTERFACE; MEDIA; STRIP | Anisotropic functionally gradient materials; Higher order crack tip fields; Isotropic functionally gradient materials; Orthotropic functionally gradient materials; Transiently propagating cracks | Anisotropy; Functionally graded materials; Anisotropic functionally gradient material; Crack tip fields; Functionally gradient materials; Higher order crack tip fields; Isotropic functionally gradient material; Isotropics; Orthotropic functionally gradient material; Transiently propagating crack; Laplace equation | English | 2025 | 2025-04 | 10.1016/j.apm.2024.115849 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Associations Between Serum Sodium, Peritoneal Dialysis-Associated Peritonitis, and Mortality in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) | Rationale & Objective: The clinical consequences of hyponatremia among patients receiving peritoneal dialysis (PD) are poorly understood. This study sought to evaluate the association of variations in serum sodium with peritoneal dialysis-associated peritonitis and death. Study Design: Multicenter observational cohort study. Settings & Participants: 23,707 participants in the Peritoneal Dialysis Outcomes and Practice Patterns Study (PDOPPS) in 8 countries between 2014 and 2022 with a serum sodium measure available at study enrollment. Predictor: Serum sodium categories (= 142 mEq/L) at study enrollment. Outcome: Time to first peritonitis episode and all-cause mortality. Analytical Approach: Cause-specific hazards models adjusted for demographic, comorbidity, and treatment characteristics. Secondary analyses using average serum sodium levels over time and evaluation of modification of the association between serum sodium and study outcomes by use of icodextrin as well as patient characteristics and PD modality. Results: Compared to a serum sodium of 140-141 mEq/L (n = 5,065), those with a sodium of = 142 mEq/L (AHR, 1.16 [95% CI, 1.03-1.30]) were all associated with higher mortality. Associations between serum sodium and mortality were similar across all patient characteristic and PD modality subgroups. Peritonitis risk was not detectably different across serum sodium categories regardless of treatment with icodextrin. Limitations: Lack of standardization/validation of serum sodium measures across sites; icodextrin use was limited to a subset of patients. Conclusions: Variations in serum sodium were associated with death but not peritonitis risk. Future studies are needed to understand the mechanisms underpinning these associations and whether modification of serum sodium would improve outcomes among those receiving PD. | Teitelbaum, Isaac; Zhao, Junhui; Tu, Charlotte; Bieber, Brian; Davies, Simon; Johnson, David W.; Kawanishi, Hideki; Kim, Yong-Lim; Kanjanabuch, Talerngsak; Pisoni, Ronald L.; Perl, Jeffrey | Univ Colorado Hosp, Sch Med, Dept Med, Div Kidney Dis & Hypertens, Aurora, CO USA; Arbor Res Collaborat Hlth, Ann Arbor, MI USA; Keele Univ, Sch Med, Fac Med & Heath Sci, Keele, England; Univ Queensland, Australasian Kidney Trials Network, Brisbane, Australia; Princess Alexandra Hosp, Dept Kidney & Transplant Serv, Brisbane, Australia; Translat Res Inst, Brisbane, Australia; Tsuchiya Gen Hosp, Hiroshima, Japan; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Nephrol, Daegu, South Korea; Chulalongkorn Univ, Ctr Excellence Kidney Metab Disorders, Bangkok, Thailand; Chulalongkorn Univ, Fac Med, Dept Med, Div Nephrol, Bangkok, Thailand; St Michaels Hosp, Dept Med, Div Nephrol, Toronto, ON, Canada; St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON, Canada | 57204346479; 59114469500; 57209155030; 53982698300; 7403126061; 34975083900; 7103248513; 59903684600; 13609834900; 7004217145; 57192120457 | isaac.teitelbaum@ucdenver.edu; | AMERICAN JOURNAL OF KIDNEY DISEASES | AM J KIDNEY DIS | 0272-6386 | 1523-6838 | 86 | 1 | SCIE | UROLOGY & NEPHROLOGY | 2024 | 8.2 | 5.6 | 0 | 2025-06-11 | 0 | 0 | HYPONATREMIA | Hyponatremia; infection; mortality; peritoneal dialysis; peritoneal dialysis associated peritonitis; peritonitis | albumin; calcium; creatinine; diuretic agent; hemoglobin; icodextrin; phosphorous acid; potassium; serotonin antagonist; serotonin noradrenalin reuptake inhibitor; tricyclic antidepressant agent; adult; all cause mortality; Article; body mass; cellulitis; cerebrovascular disease; cohort analysis; comorbidity; congestive heart failure; death; demographics; diabetes mellitus; estimated glomerular filtration rate; female; follow up; hazard ratio; human; hypertension; hyponatremia; independent variable; laboratory test; magnesium blood level; major clinical study; male; middle aged; multicenter study; neurologic disease; observational study; outcomes research; peritoneal dialysis; peritonitis; secondary analysis; sensitivity analysis; sodium blood level; urine volume | English | 2025 | 2025-07 | 10.1053/j.ajkd.2025.02.605 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Compound K-enriched Korean red ginseng prevents lung cancer progression by targeting cancer cells and fibroblasts | Background: Despite the efficacy of anticancer drugs, patients frequently experience relapse, metastasis, and resistance. A promising therapeutic approach not only targets cancer cell growth but also modulates cancer-associated fibroblasts, which support malignancies. Compound K (CK), a metabolite derived from red ginseng, has demonstrated anticancer properties. Recently, we developed a CK-enriched red ginseng extract (CKP) and explored its potential to suppress lung cancer by inhibiting cancer cell proliferation and inactivating fibroblasts. Methods: To evaluate the in vitro efficacy of CKP in inhibiting lung cancer cell proliferation, MTT and colony formation assays were performed. The apoptotic effects of CKP on lung cancer cells were assessed using Western blot and flow cytometry. Furthermore, the ability of CKP to inhibit TGF beta 1-induced migration of cancer cells was investigated through Western blot, RT-PCR, and a wound healing assay. Additionally, the impact of CKP on lung fibroblast inactivation was examined via Western blot and RT-PCR analysis. For in vivo experiments, a xenograft model was utilized, incorporating a combination of lung cancer cells and lung fibroblasts in xenografts. Results: CKP significantly reduced the proliferation and invasiveness of TGF-beta 1-stimulated A549 cells, demonstrating its potential to inactivate lung fibroblasts. Additionally, CKP inhibited the secretion of cytokines, such as interleukin-6, interleukin-8, and TGF-beta 1, by activated fibroblasts. In vivo, CKP markedly inhibited tumor growth in the xenograft model. Conclusion: In conclusion, CKP effectively induced apoptosis in lung cancer cells, suppressed metastasis, and inactivated fibroblasts, thereby preventing cancer invasion and reducing extracellular matrix production, highlighting its potential as a novel anticancer agent. | Hwang, Jung Ho; Park, Se Yong; Kang, Ju-Hee; Jung, Hyun Jin; Park, Jiwon; Maeng, Han-Joo; Choi, Min-Koo; Song, Ha Suk; Song, Im-Sook; Oh, Seung Hyun | Gachon Univ, Coll Pharm, Incheon, South Korea; Seoul Natl Univ, Coll Vet Med, Seoul, South Korea; Dankook Univ, Coll Pharm, Cheonan, South Korea; Nutrapanax Co Ltd, Seoul, South Korea; Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug D, Vessel Organ Interact Res Ctr, Res Inst Pharmaceut Sci,Coll Pharm, Daegu, South Korea | Oh, Seung/AAN-6744-2021 | 58126426800; 57219992401; 56434883500; 57207380797; 59160801300; 6603632250; 8695781400; 59725996700; 7201564500; 57207182566 | eyeball@snu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 49 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 0 | 2025-05-07 | 0 | 0 | CAF; Compound K; Fibroblast; Korean red ginseng; Lung cancer | EPITHELIAL-MESENCHYMAL TRANSITION; TGF-BETA; PANAX-GINSENG; TUMOR-GROWTH; MCF-7 CELLS; APOPTOSIS; EXTRACT; METABOLITE; EXPRESSION; MATRIX | CAF; Compound K; Fibroblast; Korean red ginseng; Lung cancer | antineoplastic agent; compound K enriched red ginseng extract; ginseng extract; ginsenoside CK; ginsenoside F1; ginsenoside F2; ginsenoside PPD; ginsenoside PPT; ginsenoside Rb 1; ginsenoside Rb 2; ginsenoside Rc; ginsenoside Rd; ginsenoside Re; ginsenoside Rf; ginsenoside Rg 1; ginsenoside Rg 3; ginsenoside Rh 1; ginsenoside Rh 2; transforming growth factor beta1; unclassified drug; animal experiment; animal model; animal tissue; antineoplastic activity; antiproliferative activity; apoptosis; area under the curve; Article; cancer associated fibroblast; cancer cell; cancer inhibition; cell migration; cell proliferation; colony formation; controlled study; drug efficacy; drug targeting; female; flow cytometry; human; human cell; in vitro study; in vivo study; lung cancer; lung fibroblast; male; maximum plasma concentration; mouse; MTT assay; nonhuman; proapoptotic activity; real time polymerase chain reaction; time to maximum plasma concentration; tumor xenograft; Western blotting; wound healing assay | English | 2025 | 2025-07 | 10.1016/j.jgr.2025.03.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Expanding Horizons in Quantum Chemical Studies: The Versatile Power of MRSF-TDDFT | While traditional quantum chemical theories have long been central to research, they encounter limitations when applied to complex situations. Two of the most widely used quantum chemical approaches, Density Functional Theory (DFT) and Time-Dependent Density Functional Theory (TDDFT), perform well in cases with relatively weak electron correlation, such as the ground-state minima of closed-shell systems (Franck-Condon region). However, their applicability diminishes in more demanding scenarios. These limitations arise from the reliance of DFT on a single-determinantal framework and the inability of TDDFT to capture double and higher excited configurations in its response space.The recently developed Multi-Reference Spin-Flip Time-Dependent Density Functional Theory (MRSF-TDDFT) successfully overcomes these challenges, pushing the boundaries of DFT methods. MRSF-TDDFT is exceptionally versatile, making it suitable for various applications, including bond-breaking and bond-forming reactions, open-shell singlet systems such as diradicals, and a more accurate depiction of transition states. It also provides the correct topology for conical intersections (CoIns) and incorporates double excitations into the response space for a more precise description of excited states. With the help of its formal framework, core-hole relaxation for accurate X-ray absorption prediction can be also done readily. Notably, MRSF-TDDFT achieves an equal footing description of ground and excited states, with its dual-reference framework ensuring a balanced treatment of both dynamic and nondynamic electron correlations for high accuracy.In predictive tasks, such as calculating adiabatic singlet-triplet gaps, MRSF-TDDFT achieves accuracy comparable to that of far more computationally expensive coupled-cluster methods. The missing doubly excited state of H2 observed in TDDFT is accurately captured by MRSF-TDDFT, which also reproduces the correct asymptotic bond-breaking potential energy surface. Furthermore, the CoIns of butadiene, missed by both TDDFT and Complete-Active Space Self-Consistent Field (CASSCF) methods, are successfully recovered by MRSF-TDDFT, achieving results consistent with high-level theories, an important aspect for successful study of photochemical processes. Additionally, the common issue of CASSCF overestimating bright states (ionic states) due to the missing dynamic correlation is effectively resolved by MRSF-TDDFT.Despite its numerous advancements, MRSF-TDDFT retains the computational efficiency of conventional TDDFT, making it a practical tool for routine calculations. In addition, it has been demonstrated that the prediction accuracy of MRSF-TDDFT can be further enhanced through the development of tailor-made exchange-correlation functionals, paving the way for the creation of new, specialized functionals. Consequently, with its remarkable versatility, high accuracy, and computational practicality, this innovative method significantly expands scientists' ability to explore complex molecular behaviors and design advanced materials, including applications in photobiology, organic LEDs, photovoltaics, and spintronics, to name a few. | Lee, Seunghoon; Park, Woojin; Choi, Cheol Ho | Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea | ; Lee, Seunghoon/AAB-4846-2021 | 57194591254; 57223952329; 7402958948 | cchoi@knu.ac.kr; | ACCOUNTS OF CHEMICAL RESEARCH | ACCOUNTS CHEM RES | 0001-4842 | 1520-4898 | 58 | 2 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 17.7 | 5.6 | 11.32 | 2025-05-07 | 7 | 7 | DENSITY-FUNCTIONAL THEORY; POTENTIAL-ENERGY SURFACES; INTERSECTION; DYNAMICS | 1,3 butadiene; absorption; adiabaticity; article; density functional theory; electron; ionization; light emitting diode; photobiology; photochemistry; prediction; X ray analysis | English | 2025 | 2025-01-02 | 10.1021/acs.accounts.4c00640 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Ginsenoside Rg5 inhibits platelet aggregation by regulating GPVI signaling pathways and ferric chloride-induced thrombosis | Background: Platelet hyperactivation is a major factor in thrombotic complications such as myocardial infarction and ischemic stroke. Ginsenoside Rg5 is a minor ginsenoside, and among its various beneficial pharmacological effects, its antithrombotic potential has not been extensively studied. Methods: Human platelets were isolated and treated with Rg5 (35-100 mu M) before stimulation with agonists such as collagen, thrombin, and U46619. Platelet aggregation, granule secretion, calcium mobilization, thromboxane A2 production, fibrinogen binding, and clot retraction were evaluated. The effects of Rg5 on signaling pathways were determined via Western blot analysis of key proteins. In vivo, the antithrombotic efficacy was assessed using ferric chloride (FeCl3)-induced thrombosis in mice. Results: Rg5 dose-dependently inhibited collagen-induced platelet aggregation (IC50 = 42.5 mu M) and selectively inhibited GPVI-mediated signaling compared to thrombin and U46619. Rg5 suppressed intracellular calcium mobilization, granule secretion, and thromboxane A2 production, with no cytotoxicity observed. Rg5 downregulated key signaling proteins (p-PI3K, p-AKT, p-cPLA2, and p-p38) while upregulating p-VASP (S157 and S239), suggesting its role in elevating cyclic nucleotide signaling. Additionally, Rg5 inhibited CD162 expression that was induced in the presence of collagen and oxidized low-density lipoprotein. It also prevented fibrinogen and fibronectin binding and significantly reduced clot retraction. In vivo, Rg5 (20 mg/kg) significantly prolonged the carotid artery occlusion time and prevented thrombus formation, outperforming aspirin (100 mg/kg). Conclusion: Ginsenoside Rg5 exhibits potent antiplatelet activity by selectively targeting GPVI-mediated platelet activation and modulating key intracellular signaling pathways. These results suggest that Rg5 could be utilized to develop safer and natural antiplatelet therapies. | Akram, Abdul Wahab; Shin, Jung-Hae; Batmunkh, Uyanga; Saba, Evelyn; Kang, Yong-Myung; Jung, Sunjun; Han, Jee Eun; Kim, Sung Dae; Kwak, Dongmi; Kwon, Hyuk-woo; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu, South Korea; Pir Mehr Ali Shah Arid Agr Univ, Fac Vet & Anim Sci, Dept Vet Basic Sci, Rawalpindi, Pakistan; Far East Univ, Dept Biomed Lab Sci, 76-32 Daehak Gil Gamgok Myeon, Eumseong 27601, Chungcheongbug Do, South Korea; Kyungpook Natl Univ, Inst Vet Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea | Saba, Evelyn/JLN-1878-2023; Rhee, Man/O-5705-2016 | 59166934200; 56244056800; 59507069500; 56721112000; 59702372200; 59740013100; 59510656600; 59540403300; 7007148758; 55200547400; 57211035357 | kwonhw@kdu.ac.kr; rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 49 | 4 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2024 | 5.6 | 5.6 | 0 | 2025-05-07 | 1 | 1 | Anti-platelet effects; Cardioprotective effects; Ginsenoside Rg5; GPVI signaling | PANAX-GINSENG; ACTIVATION; DISEASE; CELLS | Anti-platelet effects; Cardioprotective effects; FeCl<sub>3</sub>-Induced thrombosis; Ginsenoside Rg5; GPVI signaling | 15 hydroxy 11alpha,9alpha epoxymethanoprosta 5,13 dienoic acid; acetylsalicylic acid; beta actin; calcium; collagen receptor; fibronectin; ginsenoside; ginsenoside rg 5; gpvi collagen receptor; mitogen activated protein kinase p38; thrombin; thromboxane A2; unclassified drug; animal cell; antiplatelet activity; antithrombotic activity; Article; blood clot retraction; blood clotting; blood flow; calcium cell level; carotid artery occlusion; chemical structure; controlled study; cytotoxicity; down regulation; ferric chloride-induced thrombosis; fluorescence activated cell sorting; human; human cell; in vitro study; in vivo study; intracellular signaling; nonhuman; rat; serotonin release; signal transduction; thrombocyte activation; thrombocyte adhesion; thrombocyte aggregation; Western blotting | English | 2025 | 2025-07 | 10.1016/j.jgr.2025.04.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Potent P2Y12 inhibitors in patients with acute myocardial infarction and cardiogenic shock | Background Although potent P2Y(12) inhibitors, such as ticagrelor and prasugrel, are standard treatment in patients with acute myocardial infarction (AMI), evidence for their efficacy and safety compared with clopidogrel is limited in patients with AMI complicated by cardiogenic shock. Methods Among 28,949 patients from the nationwide pooled registry of KAMIR-NIH and KAMIR-V, a total of 1482 patients (5.1%) with AMI and cardiogenic shock who underwent percutaneous coronary intervention of the culprit vessel were selected. Primary outcome was major adverse cardiovascular event (MACE, a composite of cardiac death, MI, repeat revascularization and definite stent thrombosis) and major secondary outcome was Bleeding Academic Research Consortium (BARC) type 2 or greater bleeding at 2 years. Results Among the study population, 537 patients (36.2%) received potent P2Y(12) inhibitors and 945 patients (63.8%) received clopidogrel after index procedure. The risk of MACE was significantly lower in the potent P2Y(12) inhibitors group than in the clopidogrel group (16.6% versus 24.7%; adjusted hazard ratio [HR], 0.76 [95% CI 0.59-0.99]; P = 0.046). Regarding BARC type 2 or greater bleeding, there was no significant difference between the potent P2Y(12) inhibitors group and the clopidogrel group (12.5% versus 10.7%; adjusted HR, 1.36 [95% CI 0.98-1.88]; P = 0.064). Significant interaction was observed in patients aged >= 75 years (interaction P = 0.021) or venoarterial extracorporeal membrane oxygenator (VA-ECMO) use (interaction P = 0.015) for significantly increased risk of BARC type 2 or greater bleeding following the use of potent P2Y(12) inhibitors. Conclusions In patients with AMI complicated by cardiogenic shock, the use of potent P2Y(12) inhibitors was associated with a lower risk of MACE compared with clopidogrel, without an increased risk of BARC type 2 or greater bleeding. The current data supports the use of potent P2Y(12) inhibitors in patients with AMI and cardiogenic shock, except in patients aged >= 75 years or receiving VA-ECMO support. | Jo, Jinhwan; Lee, Seung Hun; Joh, Hyun Sung; Kim, Hyun Kuk; Kim, Ju Han; Hong, Young Joon; Ahn, Young Keun; Jeong, Myung Ho; Hur, Seung Ho; Kim, Doo-Il; Chang, Kiyuk; Park, Hun Sik; Bae, Jang-Whan; Jeong, Jin-Ok; Park, Yong Hwan; Yun, Kyeong Ho; Yoon, Chang-Hwan; Kim, Yisik; Hwang, Jin-Yong; Kim, Hyo-Soo; Kwon, Woochan; Shin, Doosup; Ha, Junho; Kim, Chang Hoon; Choi, Ki Hong; Park, Taek Kyu; Yang, Jeong Hoon; Song, Young Bin; Hahn, Joo-Yong; Choi, Seung-Hyuk; Gwon, Hyeon-Cheol; Lee, Joo Myung; KAMIR Investigators | Sungkyunkwan Univ, Heart Vasc Stroke Inst, Samsung Med Ctr, Dept Med,Div Cardiol,Sch Med, Seoul, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Heart Ctr, Dept Internal Med,Med Sch,Div Cardiol, Gwangju, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Cardiovasc Ctr, Coll Med, Seoul, South Korea; Univ Chosun, Chosun Univ Hosp, Dept Internal Med, Coll Med, Gwangju, South Korea; Univ Chosun, Chosun Univ Hosp, Cardiovasc Ctr, Coll Med, Gwangju, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; Inje Univ, Haeundae Baek Hosp, Dept Cardiol, Haeundae Baek Hosp,Coll Med, Busan, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Internal Med,Div Cardiol, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Chungbuk Natl Univ, Coll Med, Dept Internal Med, Cheongju, South Korea; Chungnam Natl Univ, Chungnam Natl Univ Hosp, Coll Med, Daejeon, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Sch Med, Chang Won, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam Si, Gyeonggi Do, South Korea; Chonbuk Natl Univ Hosp, Jeonju, South Korea; Chonbuk Natl Univ, Med Sch, Jeonju, South Korea; Gyeongsang Natl Univ, Dept Internal Med, Sch Med, Jinju, South Korea; Gyeongsang Natl Univ Hosp, Jinju, South Korea; Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Cardiovasc Ctr, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Seoul, South Korea; St Francis Hosp & Heart Ctr, Dept Cardiol, Roslyn, NY USA | Yoon, Changhwan/MXM-0567-2025; Song, Young Bin/IYJ-6953-2023; Hahn, Joo-Yong/AAU-7250-2020; Yun, Kyeong Ho/IYS-8810-2023; Lee, Seung/AAW-6430-2021; choi, sun ryoung/AGZ-1893-2022; Hong, Young/O-7996-2018 | 58539392300; 57214839313; 57192918948; 57206210646; 57196169644; 13310329100; 59309496700; 59716263300; 34570274500; 8635545900; 25521288100; 59644125200; 8699381000; 57210973601; 56799369500; 14424664600; 57666453500; 56089313700; 59644125300; 58843097000; 57200395455; 57217586115; 58713250200; 59232843700; 55756735500; 57201088838; 45662209400; 15763569500; 12771661800; 57213560615; 6603262426; 54894745500 | drone80@hanmail.net; | CRITICAL CARE | CRIT CARE | 1364-8535 | 1466-609X | 29 | 1 | SCIE | CRITICAL CARE MEDICINE | 2024 | 9.3 | 5.6 | 0 | 2025-05-07 | 0 | 0 | Acute myocardial infarction; Cardiogenic shock; P2Y(12) inhibitors; Major cardiovascular event; Bleeding | PERCUTANEOUS CORONARY INTERVENTION; THERAPEUTIC HYPOTHERMIA; CLOPIDOGREL; PRASUGREL; TICAGRELOR; REVASCULARIZATION; THROMBOSIS; OUTCOMES | Acute myocardial infarction; Bleeding; Cardiogenic shock; Major cardiovascular event; P2Y<sub>12</sub> inhibitors | Aged; Clopidogrel; Female; Humans; Male; Middle Aged; Myocardial Infarction; Percutaneous Coronary Intervention; Platelet Aggregation Inhibitors; Prasugrel Hydrochloride; Purinergic P2Y Receptor Antagonists; Registries; Shock, Cardiogenic; Ticagrelor; Ticlopidine; Treatment Outcome; acetylsalicylic acid; clopidogrel; prasugrel; ticagrelor; antithrombocytic agent; clopidogrel; prasugrel; purinergic P2Y receptor antagonist; ticagrelor; ticlopidine; acute heart infarction; adult; Article; cardiogenic shock; cardiovascular disease; cardiovascular risk factor; clinical outcome; controlled study; coronary angiography; drug efficacy; drug safety; electrocardiography; extracorporeal oxygenation; female; heart left bundle branch block; human; loading drug dose; major clinical study; male; middle aged; non ST segment elevation myocardial infarction; percutaneous coronary intervention; propensity score; revascularization; sensitivity analysis; ST segment elevation myocardial infarction; stent thrombosis; thrombus aspiration; veno-arterial ECMO; aged; complication; drug therapy; heart infarction; procedures; register; treatment outcome | English | 2025 | 2025-02-06 | 10.1186/s13054-025-05277-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Preliminary debris flow risk assessment using infrastructure weighting | Debris flows are natural disasters that cause significant loss of life and property damage worldwide. In recent years, the risk of debris flows has increased due to population growth and the expansion of land use near mountainous areas driven by development pressures. Efficient debris flow risk assessment is essential to mitigate the damage caused by these disasters. Previous studies have relied on complex parameters such as fluid volume, velocity, and friction coefficients; however, this approach requires field investigations and laboratory experiments, making large-scale prediction difficult. In this study, a model was developed to predict large-scale debris flow damage and runout zones using a digital elevation model (DEM) and vector-based infrastructure data. This work focused on human casualties by incorporating the building occupancy time into the model. The model determines debris flow runout zones based on an empirical equation and risk assessment by overlaying five risk-weighting factors: distance decay weighting, spreading angle weighting, flow weighting, average slope weighting, and infrastructure weighting. To validate the model, it was applied to case studies in which human casualties were caused by a debris flow, and the results were compared with the actual damage patterns. It was found that regions classified as high-risk or greater in the risk map corresponded closely to the areas affected by the debris flows. Furthermore, the high-risk zones in the model matched the locations of buildings where human casualties occurred. This model has particular advantages as it can be quickly and easily applied using simple input data, making it a valuable tool for local governments to establish evacuation routes and proactive response strategies. © Springer-Verlag GmbH Germany, part of Springer Nature 2025. | Lee, Jaeho; Chae, Byung-Gon; Choi, Junghae | Department of Geology, Kyungpook National University, Daegu, 41566, South Korea; Deep Subsurface Storage and Disposal Research Center, Korea Institute of Geoscience and Mineral Resources, Yuseong District, 124 Gwahak-Ro, Daejeon, South Korea; Department of Earth Science Education, Kyungpook National University, Daegu, 41566, South Korea | 58974708900; 35782715300; 55839820300 | choi.jh@knu.ac.kr; | Landslides | LANDSLIDES | 1612-510X | 1612-5118 | SCIE | ENGINEERING, GEOLOGICAL;GEOSCIENCES, MULTIDISCIPLINARY | 2024 | 7 | 5.6 | 0 | 2025-05-07 | 0 | Debris flow risk assessment; Empirical equation; Human casualties; Risk weight | Debris flow risk assessment; Debris flows; Empirical equations; Human casualty; Loss of life; Natural disasters; Property damage; Risk weight; Risks assessments; Run outs; Risk assessment | English | Article in press | 2025 | 10.1007/s10346-025-02528-5 | 바로가기 | 바로가기 | 바로가기 | |||||||||
| ○ | ○ | Article | Sliding resistance of layered ultra-thin glass module for flexible cover window: Effect of mechanical properties and artificial neural network modeling | Recently, various flexible products such as curved, sliding, foldable, and stretchable devices have been introduced to the electronics market using flexible materials. For these products to be commercialized, the cover window module that protects the internal display from external impacts must be capable of specific deformation actions repeatedly without causing deformation or damage during operation. Additionally, structural analysis techniques are required to accelerate design processes. In this study, a finite element model for the sliding motion of the layered cover window module was developed and validated by comparing with experimental results. Based on the suggested model, the parameter study for the mechanical properties of each layer was conducted and physically explained. The relationships between mechanical properties and sliding force were identified and predicted by stepwise regression and artificial neural network methods. | Kim, Na-Im; Yoo, Areum; Choi, Jinsu; Wee, Jung-Wook | Kumoh Natl Inst Technol, Dept Mech Engn, 61 Daehak Ro, Gumi 39177, Gyeongbuk, South Korea; Samsung Elect, MX Div, Mech Proc Technol Grp 2, 302,3 Gongdan 3 Ro, Gumi 39388, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll Engn, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | 59326862400; 59524658300; 59524226000; 56673775300 | jwwee@knu.ac.kr; | THIN-WALLED STRUCTURES | THIN WALL STRUCT | 0263-8231 | 1879-3223 | 210 | SCIE | ENGINEERING, CIVIL;ENGINEERING, MECHANICAL;MECHANICS | 2024 | 6.6 | 5.6 | 0 | 2025-05-07 | 1 | 1 | Flexible cover window; Sliding motion; Finite element analysis; Statistical analysis; Plastic deformation; Artificial neural network | DESIGN; OPTIMIZATION; REGRESSION; RSM; FEM | Artificial neural network; Finite element analysis; Flexible cover window; Plastic deformation; Sliding motion; Statistical analysis | Finite element analyse; Flexible cover window; Mechanical; Neural-networks; Property; Sliding motions; Sliding resistance; Thin glass; Ultra-thin; Window effect | English | 2025 | 2025-05 | 10.1016/j.tws.2025.112994 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | Phthalates Induces Deficiency of Epidermal Barrier Proteins and Skin Barrier Dysfunction through PPAR-γ | Jung, Minyoung; Lee, Jinyoung; Jung, Young Hoon; Jeon, Hyeon Ji; Kim, Jihyun; Ahn, Kangmo; Kim, Byung Eui | Kosin Univ, Gospel Hosp, Dept Pediat, Busan, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Seoul, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Natl Jewish Hlth, Dept Pediat, Denver, CO USA | Jung, YoungHoon/LCE-3750-2024; Jeon, Hyeon Ji/HPH-4892-2023 | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | J ALLERGY CLIN IMMUN | 0091-6749 | 1097-6825 | 155 | 2 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 11.2 | 5.7 | 0 | English | 2025 | 2025-02 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | The Role of Sphingosine-1-phosphate receptor 4 (S1PR4) in the Regulation of Mucus Hypersecretion in a Murine Asthma Model | Kim, Sujeong; Jeong, Mini; Koo, Kyomoon; Kim, Sin-Jeong; Cho, You Sook | Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | J ALLERGY CLIN IMMUN | 0091-6749 | 1097-6825 | 155 | 2 | SCIE | ALLERGY;IMMUNOLOGY | 2024 | 11.2 | 5.7 | 0 | English | 2025 | 2025-02 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | 3D-printed rice cake for dysphagia diet: Effect of rice flour/κ-carrageenan/ curdlan complex gel on structure, swallowability, and storage | Rice cakes are a traditional rice-based dessert consumed in Asian countries. They are an excellent source of carbohydrates and can be used as a staple food. However, they have a hard and gummy texture. This study aims to create dysphagia-friendly rice cakes by adding kappa-carrageenan (KC) and curdlan (CD) to rice flour. Samples with various KC:CD ratios (1:1, 2:1, 3:1, and 4:1) were compared to commercial rice cakes. XRD showed typical A crystal structures that were unaffected by the complex gel. FTIR spectra indicated hydrogen bond interactions enhancing gel strength. Viscosity analysis revealed shear-thinning behavior for samples with KC:CD ratios of 1:1 and 2:1 suitable for bolus rheology. Optimized printing conditions yielded structurally stable 3D-printed rice cakes meeting the international standard for dysphagia (IDDSI levels 5 and 6). Compared to commercial rice cakes, the experimental samples exhibited lower syneresis and delayed retrogradation, suggesting improved storage stability. Complex gel incorporation offers a method for controlling structural property, swallowability, and storage stability, potentially enabling dysphagia-friendly rice cake manufacturing via 3D printing. | Kim, Jiyoon; Kim, Jung Soo; Moon, Kwang-Deog | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, 80 Daehak Ro, Daegu 41566, South Korea | 57208110209; 57211108486; 55999192900 | kdmoon@knu.ac.kr; | FUTURE FOODS | FUTURE FOODS | 2666-8335 | 11 | ESCI | FOOD SCIENCE & TECHNOLOGY | 2024 | 8.2 | 5.8 | 0 | 2025-05-07 | 1 | 1 | Personalized food; 3D food printing; Dysphagia diet; Rice cake; Rice flour; kappa-carrageenan; Curdlan | FREEZE-THAW STABILITY; BAKERY PRODUCTS; STARCH-GEL; RETROGRADATION; TEXTURE; PROTEIN; FLOUR; POLYSACCHARIDES; DIGESTIBILITY; RHEOLOGY | 3D food printing; Curdlan; Dysphagia diet; Personalized food; Rice cake; Rice flour; κ-carrageenan | English | 2025 | 2025-06 | 10.1016/j.fufo.2024.100537 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | A multi-objective benchmark for UAV path planning with baseline results | Unmanned Aerial Vehicles (UAVs) are increasingly deployed in complex environments for applications such as urban logistics, surveillance, and environmental monitoring. Path planning for UAVs in these settings is a multi-objective optimization problem that must balance conflicting criteria such as safety, efficiency, and regulatory compliance. While heuristic methods like A* and Rapidly-Exploring Random Tree (RRT) have been applied to this problem, they often struggle with convergence speed and solution quality in obstacle-rich, threedimensional spaces. Multi-Objective Evolutionary Algorithms (MOEAs) have shown strong potential for tackling such challenges, yet the absence of a comprehensive, standardized benchmark for UAV path planning continues to impede meaningful evaluation and comparison across studies. To address this gap, this paper makes three key contributions: (i) a parameterized framework for generating UAV path-planning problems across three representative environment types - urban, suburban, and mountainous - with adjustable scenario difficulty and real-world constraints such as no-fly zones; (ii) a curated benchmark suite comprising 14 diverse and rigorously designed test problems for reproducible and consistent algorithm evaluation; and (iii) baseline performance results for several state-of-the-art MOEAs, offering researchers clear reference points for future comparisons. By providing both a versatile testbed and a standardized evaluation methodology, this work aims to facilitate the development and fair assessment of UAV path-planning algorithms in realistic and challenging environments. | Darlan, Daison; Ajani, Oladayo S.; Paul, Anand; Mallipeddi, Rammohan | Kyungpook Natl Univ, Dept Artificial Intelligence, Daehak Ro, Daegu 41566, South Korea; Louisiana State Univ, Biostat & Data Sci Dept, Hlth Sci Ctr, New Orleans, LA 70112 USA | AJANI, Oladayo/HIR-9607-2022; M, Sri Srinivasa Raju/GNH-4935-2022; Mallipeddi, Rammohan/AAL-5306-2020; Darlan, Daison/KQA-9542-2024 | 58164208500; 57465126000; 56650522400; 25639919900 | daisondarlan33@gmail.com; oladayosolomon@gmail.com; apaul4@lsuhsc.edu; mallipeddi.ram@gmail.com; | SWARM AND EVOLUTIONARY COMPUTATION | SWARM EVOL COMPUT | 2210-6502 | 2210-6510 | 96 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, THEORY & METHODS | 2024 | 8.5 | 5.8 | 0 | 2025-06-11 | 0 | 0 | UAV path planning; Multi-objective optimization; Autonomous navigation | UNMANNED AERIAL VEHICLES; ALGORITHM; MOEA/D; OPTIMIZATION | Autonomous navigation; Multi-objective optimization; UAV path planning | Environmental monitoring; Heuristic methods; Micro air vehicle (MAV); Multiobjective optimization; Random forests; Target drones; Aerial vehicle; Autonomous navigation; Baseline results; Complex environments; Multi objective; Multi-Objective Evolutionary Algorithm; Multi-objectives optimization; Unmanned aerial vehicle path planning; Urban logistics; Vehicle path planning; Drones | English | 2025 | 2025-07 | 10.1016/j.swevo.2025.101968 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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