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○ Article ⓘ SymScore: Machine learning accuracy meets transparency in a symbolic regression-based clinical score generator ⓘ Self-report questionnaires play a crucial role in healthcare for assessing disease risks, yet their extensive length can be burdensome for respondents, potentially compromising data quality. To address this, machine learning-based shortened questionnaires have been developed. While these questionnaires possess high levels of accuracy, their practical use in clinical settings is hindered by a lack of transparency and the need for specialized machine learning expertise. This makes their integration into clinical workflows challenging and also decreases trust among healthcare professionals who prefer interpretable tools for decision-making. To preserve both predictive accuracy and interpretability, this study introduces the Symbolic Regression-Based Clinical Score Generator (SymScore). SymScore produces score tables for shortened questionnaires, which enable clinicians to estimate the results that reflect those of the original questionnaires. SymScore generates the score tables by optimally grouping responses, assigning weights based on predictive importance, imposing necessary constraints, and fitting models via symbolic regression. We compared SymScore's performance with the machine learning-based shortened questionnaires MCQI-6 (n=310) and SLEEPS (n=4257), both renowned for their high accuracy in assessing sleep disorders. SymScore's questionnaire demonstrated comparable performance (MAE = 10.73, R2 = 0.77) to that of the MCQI-6 (MAE = 9.94, R2 = 0.82) and achieved AUROC values of 0.85-0.91 for various sleep disorders, closely matching those of SLEEPS (0.88-0.94). By generating accurate and interpretable score tables, SymScore ensures that healthcare professionals can easily explain and trust its results without specialized machine learning knowledge. Thus, SymScore advances explainable AI for healthcare by offering a user-friendly and resource-efficient alternative to machine learning-based questionnaires, supporting improved patient outcomes and workflow efficiency. © 2024 The Author(s) ⓘ Cawiding, Olive R.; Lee, Sieun; Jo, Hyeontae; Kim, Sungmoon; Suh, Sooyeon; Joo, Eun Yeon; Chung, Seockhoon; Kim, Jae Kyoung ⓘ Department of Mathematical Sciences, KAIST, Daejeon, 34141, South Korea, Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, 34126, South Korea; Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, 34126, South Korea, Department of Mathematics, Kyungpook National University, Daegu, 41566, South Korea; Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, 34126, South Korea, Division of Applied Mathematical Sciences, Korea University, Sejong, 30019, South Korea; Department of Mathematical Sciences, KAIST, Daejeon, 34141, South Korea, Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, 34126, South Korea; Department of Psychology, Sungshin Women's University, Seoul, 02844, South Korea; Department of Neurology, Neuroscience Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 05505, South Korea; Department of Mathematical Sciences, KAIST, Daejeon, 34141, South Korea, Biomedical Mathematics Group, Pioneer Research Center for Mathematical and Computational Sciences, Institute for Basic Science, Daejeon, 34126, South Korea, Department of Medicine, College of Medicine, Korea University, Seoul, 02841, South Korea ⓘ ⓘ 57198490202; 59485256600; 57208772486; 59485256700; 55573068100; 7003659894; 34767959400; 56150933800 ⓘ jaekkim@kaist.ac.kr; ⓘ Computers in Biology and Medicine ⓘ COMPUT BIOL MED ⓘ 0010-4825 1879-0534 185 SCIE COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;MATHEMATICAL & COMPUTATIONAL BIOLOGY;BIOLOGY ⓘ 2024 6.3 5.2 0 2025-05-07 ⓘ 2 ⓘ ⓘ Clinical decision making; Explainable artificial intelligence; Interpretable machine learning; Medical questionnaires; Risk score evaluation; Shortened questionnaires; Symbolic regression ⓘ Adult; Female; Humans; Machine Learning; Male; Middle Aged; Sleep Wake Disorders; Surveys and Questionnaires; Adversarial machine learning; Contrastive Learning; Sleep research; Clinical decision making; Explainable artificial intelligence; Health care professionals; Interpretable machine learning; Machine-learning; Medical questionnaire; Risk score; Risk score evaluation; Shortened questionnaire; Symbolic regression; adult; Article; controlled study; diagnostic accuracy; diagnostic test accuracy study; explainable artificial intelligence; female; health risk assessment; human; intermethod comparison; machine learning; major clinical study; male; prediction; questionnaire; receiver operating characteristic; scoring system; sensitivity and specificity; sleep disorder; symbolic regression based clinical score generator; middle aged; sleep disorder; Risk assessment ⓘ English Final 2025 10.1016/j.compbiomed.2024.109589 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Utilization of steel slag for sustainable concrete blocks: Laboratory study on water absorption, flexural strength, carbon dioxide capture, and volumetric expansion ⓘ In this study, the applicability of steel slag in sustainable concrete blocks was experimentally evaluated by analyzing water absorption, flexural strength, carbon dioxide (CO2) capture performance, and expansion behavior. Three types of steel slag were used: basic oxygen furnace (BOF) slag, electric arc furnace (EAF)-oxidizing slag, and EAF-reducing slag. These were incorporated into a conventional concrete block mix by partially replacing the binder or fine aggregate. The results show that replacing 10 % of the binder or 35 % of the fine aggregate with steel slag did not degrade the performance (such as by increasing water absorption) compared to the reference mix. In terms of flexural strength, a reduction was observed only when 10 % of the binder was replaced with EAF-oxidizing slag. In all other cases, the flexural strength increased, with improvements of up to 127.3 % over the reference mix. The results of thermogravimetric analysis and X-ray micro-computed tomography confirmed that sustainable concrete blocks with incorporated BOF slag therein exhibited superior CO2 capture performance. Although volumetric expansion due to the reaction of free calcium oxide in BOF slag was observed when immersing the sustainable concrete blocks in water, the porous structure of the latter allowed internal voids to be filled, resulting in a denser microstructure. No negative effects, such as cracking or spalling, were observed. Therefore, the use of steel slag in sustainable concrete blocks demonstrates strong potential in terms of both mechanical performance and environmental benefits. © 2025 Elsevier Ltd ⓘ Sim, Yeonhui; Oh, Sangwoo; Song, Chiwon; Lee, Seong-Cheol; Hong, Geuntae ⓘ Department of Civil Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Civil and Environmental Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjak-gu, Seoul, 06974, South Korea; Construction Steel Application Engineering Team, Hyundai-steel, 20, Pangyoyeok-ro 241beon-gil, Bundang-gu, Gyeonggi-do, Seongnam-si, 13494, South Korea; Department of Civil Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Civil Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea ⓘ ⓘ 59529493200; 57223979407; 56472191400; 35784449900; 57193714827 ⓘ gthong@knu.ac.kr; ⓘ Journal of Building Engineering ⓘ J BUILD ENG ⓘ N/A 2352-7102 111 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL ⓘ 2024 7.4 5.2 ⓘ 0 ⓘ ⓘ Calcium carbonate; Calcium hydroxide; CO<sub>2</sub> capture; Concrete block; Steel slag ⓘ Binders; Calcium carbonate; Calcium oxide; Carbon capture; Carbon capture and utilization; Carbon dioxide; Carbon sequestration; Concrete aggregates; Concrete mixtures; Electric arcs; Electric furnaces; Expansion; Slags; Water absorption; CO2 capture; Electric-arc furnaces; Fine aggregates; Furnace slags; Laboratory studies; Oxygen furnaces; Performance; Steel slag; Sustainable concretes; Volumetric expansion; Bending strength; Concrete blocks ⓘ English Final 2025 10.1016/j.jobe.2025.113335 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Aspalathin, a key flavonoid in rooibos, restores STAT6-mediated immune dysregulation in atopic dermatitis ⓘ Atopic dermatitis (AD), a chronic inflammatory skin disease whose incidence is increasing worldwide, requires the development of alternative treatments due to limited treatment options and concerns about side effects of therapeutic agents. Aspalathin (ASP) is the primary flavonoid found in rooibos, an herb traditionally used for allergies and eczema, accounting for over 40 % of the total flavonoid content, especially in its unfermented state (Green rooibos). This research conducted a thorough investigation into the pharmacological properties of ASP on AD, emphasizing local responses via activated keratinocytes, systemic responses involving T cells and basophils, and an integrated assessment using an AD mouse model. Topical application of ASP significantly reduced AD phenotypes, including erythema, scaling, and increased skin thickness, in AD mouse model. Histological analysis indicated a decrease in the infiltration of immune cells in skin lesions. Moreover, ASP down-regulated inflammatory markers, including T helper (Th)1 and Th2 cytokines, in both skin tissues and activated mouse T cells. In particular, ASP significantly reduced serum immunoglobulin (Ig)E and IgG2a levels. ASP suppressed the expression of cytokines linked to allergy and inflammation in T cells, basophils, and keratinocytes. Mechanistically, ASP exhibited anti-inflammatory properties by inhibiting STAT6 and NFAT1 activation in AD mouse skin and in activated T cells, basophils, and keratinocytes. In conclusion, ASP displayed pronounced effectiveness in relieving AD by sophisticated modulation of immune responses across both local and systemic domains. These findings highlight ASP's promise as a therapeutic intervention for AD, providing a solid scientific basis for future exploration and development. © 2025 The Authors ⓘ Yang, Inyoung; Jeong, Na-Hee; Choi, Young-Ae; Choi, Dong Kyu; Lee, Hyun-Shik; Kwon, Taeg Kyu; Lee, Soyoung; Kim, Sang-Hyun ⓘ CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea; KNU G-LAMP Project Group, KNU Institute of Basic Sciences, School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea; Department of Immunology, School of Medicine, Keimyung University, Daegu, 42601, South Korea; Department of Innovative Pharmaceutical Sciences, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, 41566, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea ⓘ ⓘ 59163039100; 57194410234; 7404777420; 59815938900; 59858434400; 7202206057; 8537269200; 57210450420 ⓘ sy.lee@knu.ac.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 184 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ Aspalathin; Atopic dermatitis; Basophils; Keratinocytes; STAT6; T cells ⓘ Animals; Anti-Inflammatory Agents; Aspalathus; Chalcones; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Female; Flavonoids; Humans; Immunoglobulin E; Keratinocytes; Mice; Mice, Inbred BALB C; Skin; STAT6 Transcription Factor; aspalathin; cytokine; dexamethasone; flavonoid; immunoglobulin E; immunoglobulin G2a; STAT6 protein; unclassified drug; antiinflammatory agent; aspalathin; chalcone derivative; cytokine; flavonoid; immunoglobulin E; STAT6 protein; Stat6 protein, mouse; animal cell; animal experiment; animal model; animal tissue; Article; atopic dermatitis; basophil; cell infiltration; controlled study; down regulation; female; herbal tea; histopathology; immune dysregulation; immunocompetent cell; immunoglobulin blood level; keratinocyte; mouse; nonhuman; protein expression; skin thickness; T lymphocyte; topical treatment; animal; Aspalathus; atopic dermatitis; Bagg albino mouse; blood; chemistry; disease model; drug effect; drug therapy; human; immunology; metabolism; pathology; skin ⓘ English Final 2025 10.1016/j.biopha.2025.117926 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Convergence in the incompressible limit of the corner ⓘ In this paper, we treat the corner singularity expansion and its convergence result regarding the penalized system obtained by eliminating the pressure variable in the Stokes problem of incompressible flow. The penalized problem is a kind of the Lam & eacute; system, so we first discuss the corner singularity theory of the Lam & eacute; system with inhomogeneous Dirichlet boundary condition on a non-convex polygon. Considering the inhomogeneous condition, we show the decomposition of its solution, composed of singular parts and a smoother remainder near a re-entrant corner, and furthermore, we provide the explicit formulae of coefficients in singular parts. In particular, these formulae can be used in the development of highly accurate numerical scheme. In addition, we formulate coefficients in singular parts regarding the Stokes equations with inhomogeneous boundary condition and non-divergence-free property of velocity field, and thus we show the convergence results of coefficients in singular parts and remainder regarding the concerned penalized problem. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. ⓘ Choi, Hyung Jun; Kim, Seonghak; Koh, Youngwoo ⓘ Korea Univ Technol & Educ, Sch Liberal Arts, Cheonan 31253, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Kongju Natl Univ, Dept Math Educ, Kong Ju 32588, South Korea ⓘ ⓘ 55780425800; 56489490600; 56729929100 ⓘ hjchoi@koreatech.ac.kr; shkim17@knu.ac.kr; ywkoh@kongju.ac.kr; ⓘ JOURNAL OF DIFFERENTIAL EQUATIONS ⓘ J DIFFER EQUATIONS ⓘ 0022-0396 1090-2732 440 SCIE MATHEMATICS ⓘ 2024 2.3 5.3 0 2025-06-11 ⓘ 0 0 Penalty method; Corner singularity; Lam & eacute; system ⓘ SINGULAR COMPLEMENT METHOD; FINITE-ELEMENT METHODS; POISSON PROBLEM; LOCKING; DOMAINS; SYSTEM ⓘ Corner singularity; Lamé system; Penalty method ⓘ ⓘ English 2025 2025-09-25 10.1016/j.jde.2025.113415 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Inhibition of the mitochondrial permeability transition pore as a promising target for protecting auditory function in cisplatin-induced hearing loss ⓘ mPTP is a multi-protein complex that opens in mitochondria during cell death. Cisplatin-induced hearing loss is also known to be caused by mPTP opening. Thus, our study evaluated the protective effect of a novel mPTP inhibitor named DBP-iPT against cisplatin-induced hearing loss. The cell viability result showed that DBP-iPT provided a 40 % protective effect compared to the group treated with cisplatin. In addition, the DBP-iPT treated group exhibited a reduction in intracellular ROS levels, counteracting the excessive ROS accumulation induced by cisplatin at the whole cell level. Intriguingly, mitochondrial ROS levels in the DBP-iPT group were elevated three-fold compared to the cisplatin-treated group. Despite this increase in mitochondrial ROS, the mitochondrial membrane potential in the DBP-iPT group was three times higher than that of the control. These findings present intriguing contradictions to prior studies. Therefore, we investigated whether the mitochondria were damaged or not and found that DBP-iPT treatment maintained an increased portion of elongated mitochondria, suggesting autophagy-mediated removal of damaged mitochondria. This process leads to improved mitochondrial dynamics. Finally, in vivo studies confirmed that the ABR test using a mouse model showed the same pattern of protection against cisplatin-induced hearing loss in the DBP-iPT treatment group. We have identified a new target that has a protective effect against cisplatin-induced hearing loss. Therefore, this study is expected to provide valuable insights as it focuses on targeting mPTP opening to protect against ototoxicity caused by cisplatin. This discovery will serve as a significant foundation for future research. © 2024 ⓘ Kim, Ye-Ri; Jun, Sujin; Jung, Sunhwa; Lee, Byeonghyeon; Lee, Sang-Hee; Lee, Jaehyuk; Hwang, Jong-Su; Thoudam, Themis; Lee, Hoyul; Sinam, Ibotombi Singh; Jeon, Jae-Han; Lee, Kyu-Yup; Min, Sun-Joon; Kim, Un-Kyung ⓘ Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea, Advanced Bio-Resource Research Center, Kyungpook National University, Daegu, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea, School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, South Korea; Department of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University ERICA, Ansan, South Korea; New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (KMEDI-Hub), Daegu, South Korea; Center of Research Equipment (104-Dong), Korea Basic Science Institute, Ochang, Chungbuk, Cheongju, 28119, South Korea; Advanced Bio-Resource Research Center, Kyungpook National University, Daegu, South Korea; Advanced Bio-Resource Research Center, Kyungpook National University, Daegu, South Korea; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, 41404, South Korea; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, 41404, South Korea; Bio-Medical Research Institute, Kyungpook National University Hospital, Daegu, South Korea; Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, 41404, South Korea, Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, 41404, South Korea; Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Applied Chemistry, Center for Bionano Intelligence Education and Research, Hanyang University ERICA, Ansan, South Korea, Department of Chemical & Molecular Engineering, Hanyang University ERICA, Ansan, South Korea; Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, 41566, South Korea, School of Life Sciences, BK21 plus KNU Creative BioResearch Group, Kyungpook National University, Daegu, 41566, South Korea ⓘ ⓘ 56048344100; 59480669700; 55908010900; 56384026400; 58743241400; 59479710600; 59480669800; 57192905626; 58017533900; 57846985600; 36910340400; 22135779500; 7202852233; 7102248968 ⓘ kylee@knu.ac.kr; sjmin@hanyang.ac.kr; kimuk@knu.ac.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 182 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ Autophagy; Cisplatin; Hearing loss; Mitochondrial permeability transition pore; Reactive oxygen species ⓘ Animals; Antineoplastic Agents; Autophagy; Cell Survival; Cisplatin; Evoked Potentials, Auditory, Brain Stem; Hearing Loss; Humans; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Reactive Oxygen Species; 4 [2 [(3,4 dichlorobenzyl)oxy]phenyl] 1 (1 isopropylpyrrolidin 3 yl) 1h 1,2,3 triazole; calcium ion; cisplatin; mitochondrial permeability transition pore; protein inhibitor; reactive oxygen metabolite; triazole derivative; unclassified drug; antineoplastic agent; carrier protein; cisplatin; reactive oxygen metabolite; animal cell; animal experiment; animal model; animal tissue; Article; autophagy (cellular); calcium transport; cell damage; cell structure; cell viability; controlled study; drug targeting; evoked brain stem auditory response; hearing; hearing impairment; in vivo study; male; mitochondrial dynamics; mitochondrial membrane potential; mitochondrion; mouse; nonhuman; whole cell; animal; C57BL mouse; cell survival; drug effect; hearing impairment; human; metabolism; mitochondrion; prevention and control ⓘ English Final 2025 10.1016/j.biopha.2024.117767 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Isoniazid and nicotinic hydrazide hybrids mitigate trehalose-6,6’-dimycolate-induced inflammatory responses and pulmonary granulomas via Syk/PI3K pathways: A promising host-directed therapy for tuberculosis ⓘ Granulomas, dense clusters of immune cells and bacteria, are critical barriers in tuberculosis (TB) treatment. Recent advancements in TB management have highlighted granuloma control as a potential host-directed therapy (HDT) strategy. Although isoniazid (INH) is the first-line drug for TB therapy, its efficacy is limited to non-replicating Mycobacterium tuberculosis (Mtb) under granulomatous conditions, necessitating the development of more effective derivatives. In this study, hybrid compounds of isoniazid, designated as INH-D1 and INH-D2, were synthesized and evaluated for their effects on controlling inflammatory responses and pulmonary granuloma lesions induced by trehalose-6,6′-dimycolate (TDM), a glycolipid of Mtb. Both INH-D1 and INH-D2 demonstrated stronger inhibitory effects on inflammatory mediators (TNF-α, interleukin-6, co-stimulatory molecules, and MHC class I) in TDM-stimulated macrophages compared to original INH. These anti-inflammatory effects were mediated by the inhibition of Syk, p38, PI3K, and NF-κB transcription. INH-D1 and INH-D2 exhibited stronger binding energies to Syk and PI3Kα/β than INH, which are known as proximal kinases and key mediator in TDM-mediated inflammatory responses. Oral administration of INH-D2 successfully relieved TDM-induced pulmonary granuloma pathology by reducing innate immune cell infiltration, hypoxic conditions in the lungs, and systemic inflammation by decreasing serum cytokines and chemokines. In contrast, original INH and INH-D1 did not effectively alleviate pulmonary granuloma pathology. These findings demonstrate that the novel molecule INH-D2 is effective in treating pulmonary granulomas owing to its strong anti-inflammatory effects, highlighting it as a promising HDT candidate for the management of pulmonary tuberculosis, thereby providing a strategic alternative to standard anti-TB antibiotics. © 2025 ⓘ Song, Ha-Yeon; Yoo, Bo-Gyeong; Lee, Yuna; Lim, Jae Yoon; Gu, Eun Ji; Jeon, Jongho; Byun, Eui-Baek ⓘ Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, South Korea; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, South Korea, Department of Food Science and Technology, Kongju National University, Yesan, 32439, South Korea; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, South Korea; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, South Korea, Department of Food and Nutrition, Chungnam National University, Daejeon, 34134, South Korea; Department of Applied Chemistry, College of Engineering, Kyungpook National University, Daegu, 41566, South Korea; Department of Applied Chemistry, College of Engineering, Kyungpook National University, Daegu, 41566, South Korea; Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongeup, 56212, South Korea ⓘ ⓘ 56949432500; 57562207600; 57209136392; 57327025100; 58485447700; 35082028100; 21734357100 ⓘ ebbyun80@kaeri.re.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 183 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ Anti-inflammation; Host-directed therapy; Isoniazid hybrids; Pulmonary granuloma; Trehalose-6,6’-dimycolate; Tuberculosis ⓘ Animals; Anti-Inflammatory Agents; Antitubercular Agents; Cord Factors; Female; Granuloma; Granuloma, Respiratory Tract; Inflammation; Inflammation Mediators; Isoniazid; Lung; Macrophages; Mice; Mice, Inbred C57BL; Mycobacterium tuberculosis; Phosphatidylinositol 3-Kinases; RAW 264.7 Cells; Signal Transduction; Syk Kinase; Tuberculosis, Pulmonary; chemokine; cord factor; cytokine; dexamethasone; glycolipid; interleukin 6; isoniazid; ligand; nicotinic hydrazide; phosphatidylinositol 3 kinase; pimonidazole; protein kinase Syk; tumor necrosis factor; unclassified drug; antiinflammatory agent; autacoid; isoniazid; phosphatidylinositol 3 kinase; protein kinase Syk; Syk protein, mouse; tuberculostatic agent; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; cell infiltration; cell viability; controlled study; drug synthesis; first-line treatment; flow cytometry; histopathology; host-directed therapy; hybrid; hypoxia; immunocompetent cell; inflammation; ligand binding; lung granuloma; lung tuberculosis; macrophage; MTT assay; Mycobacterium tuberculosis; nonhuman; protein structure; proton nuclear magnetic resonance; RAW 264.7 cell line; tuberculosis; Western blotting; animal; C57BL mouse; drug effect; drug therapy; female; granuloma; lung; lung granuloma; lung tuberculosis; metabolism; mouse; pathology; signal transduction ⓘ English Final 2025 10.1016/j.biopha.2024.117798 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Metabolite phenotyping of kobusin and identification of glutathione conjugates with kobusin catechol metabolite ⓘ We aimed to investigate the metabolic pathways of kobusin, a tetrahydrofurofuran lignan with benzo[1,3]dioxole group, which exhibits antioxidant, anti-inflammatory, and anticancer activities. The metabolic profiles of kobusin, following incubation with hepatocytes and human liver microsomes (HLMs), were categorized into three clusters using ion identity molecular networking, with each cluster subsequently linked by glucuronidation and sulfation. These clusters were predicted to correspond to demethylenation, demethylation, and methylation with demethylenation. The structures of the metabolites and the responsible metabolizing enzymes were further characterized using hepatocytes, HLMs, S9 fractions, cDNA-expressed cytochrome P450 isozymes (CYPs), UDP-glucuronosyltransferase isozymes (UGTs), and sulfotransferases (SULTs). Kobusin yielded five phase 1 metabolites, including kobusin catechol (M1) formed via CYP2C8, CYP2C9, CYP2C19, and CYP3A4/5; O-desmethylkobusin (M2 and M3) via CYP2C9 and CYP2C19; and hydroxykobusin (M4 and M5) via CYP3A4/5. The major phase 1 metabolites (M1, M2, and M3) were subsequently converted into 14 phase 2 metabolites, including O-methyl-M1 (M6–M8) via catechol O-methyltransferase, as well as six glucuronide and sulfate conjugates of kobusin metabolites (M1-G, M2-G, M3-G, M6-G, M7-G, and M8-G; M1-S, M2-S, M3-S, M6-S, and M7-S) formed by UGTs and SULTs, respectively. Two glutathione (GSH) conjugates of the reactive intermediate derived from M1 (kobusin catechol) were identified after incubation of kobusin with HLMs in the presence of NADPH and GSH; however, these conjugates were not detected in hepatocyte incubations. In conclusion, kobusin undergoes extensive metabolism, yielding a total of 19 metabolites in human hepatocytes. These findings provide insight into the potential contributions of metabolizing enzymes to kobusin's pharmacokinetics and drug interactions associated with the reactive intermediate of M1. © 2025 The Authors ⓘ Lee, Min Seo; Kim, Ju-Hyun; Cho, Yong-Yeon; Lee, Joo Young; Kang, Han Chang; Song, Im-Sook; Lee, Hye Suk ⓘ College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea; College of Pharmacy, Yeungnam University, Gyeongsan, 38541, South Korea; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea; BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit, Vessel-Organ Interaction Research Center (VOICE), Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, Daegu, 41566, South Korea; College of Pharmacy, The Catholic University of Korea, Bucheon, 14662, South Korea ⓘ ⓘ 57225079010; 59772234500; 55472207900; 57215684977; 59734276900; 7201564500; 59734585600 ⓘ isssong@knu.ac.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 189 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 N/A ⓘ 0 ⓘ ⓘ drug-metabolizing enzymes; GSH conjugates; ion identity molecular networking; Kobusin; metabolite identification ⓘ catechol; catechol methyltransferase; cytochrome P450 2C19; cytochrome P450 2C8; cytochrome P450 2C9; cytochrome P450 3A4; cytochrome P450 3A5; cytochrome P450 isoenzyme; drug metabolite; glucuronide; glucuronosyltransferase; glutathione; hydroxykobusin M4; hydroxykobusin M5; kobusin; kobusin catechol; o desmethylkobusin M2; o desmethylkobusin M3; reduced nicotinamide adenine dinucleotide phosphate; sulfate; sulfotransferase; unclassified drug; Article; chemical modification; chemical structure; controlled study; demethylation; demethylenation; dog; drug conjugation; drug metabolism; glucuronidation; human; human cell; liver cell; liver microsome; metabolic fingerprinting; metabolic stability; methylation; mouse; nonhuman; phenotype; rat; sulfation ⓘ English Final 2025 10.1016/j.biopha.2025.118255 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ On integral convexity, variational solutions and nonlinear semigroups ⓘ In this paper we provide a different approach for existence of the variational solutions of the gradient flows associated to functionals on Sobolev spaces studied in the paper by B & ouml;gelein et al. (2020) [7]. The crucial condition is the convexity of the functional under which we show that the variational solutions coincide with the solutions generated by the nonlinear semigroup associated to the functional. For integral functionals of the form F(u) = Omega f ( x, Du ( x )) dx , where f ( x, ) is C 1 in , we also make some remarks on the connections between convexity of F (called the integral convexity of f ) and certain monotonicity conditions of the gradient map D xi f . In particular, we provide an example to show that even for functions of the simple form f = f ( ), the usual quasimonotonicity of D xi f is not sufficient for the integral convexity of f . (c) 2025 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies. ⓘ Kim, Seonghak; Yan, Baisheng ⓘ Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Michigan State Univ, Dept Math, E Lansing, MI 48824 USA ⓘ ⓘ 56489490600; 7201858667 ⓘ shkim17@knu.ac.kr; yanb@msu.edu; ⓘ JOURNAL DE MATHEMATIQUES PURES ET APPLIQUEES ⓘ J MATH PURE APPL ⓘ 0021-7824 1776-3371 194 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2024 2.3 5.3 0 2025-05-07 ⓘ 0 0 Integral convexity; Variational solutions; Semigroups; Monotonicity conditions ⓘ EXISTENCE THEOREMS; PARTIAL REGULARITY; SYSTEMS; SEMICONTINUITY; QUASICONVEXITY; EQUATIONS; CALCULUS ⓘ Integral convexity; Monotonicity conditions; Semigroups; Variational solutions ⓘ ⓘ English 2025 2025-02 10.1016/j.matpur.2025.103662 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Protectin D1, an omega-3–derived lipid mediator, resolves mast cell–driven allergic inflammation via FcεRⅠ signaling ⓘ Protectin D1 (PD1) derived from docosahexaenoic acid (DHA) has shown promise in resolving inflammation. Mast cells are critical drivers of allergic inflammation, releasing inflammatory mediators such as histamine and pro-inflammatory cytokines. This study assesses the effectiveness of PD1 in counteracting mast cell-mediated allergic inflammation. In vivo, two well-established mouse models were employed: IgE-mediated passive cutaneous anaphylaxis (PCA) and ovalbumin-induced active systemic anaphylaxis (ASA). The oral administration of PD1 markedly suppressed PCA reactions, including ear swelling, plasma extravasation of Evans blue and mast cell degranulation. In the ASA model, oral PD1 administration dose-dependently alleviated hypothermia and reduced elevated serum levels of IgE, histamine, and IL-4. Mechanistic insights were gained through studies in the RBL-2H3 and primary mast cells derived from mouse bone marrow, where PD1 inhibited IgE-mediated degranulation and decreased intracellular calcium influx by blocking FcεRⅠ signaling pathways involving Lyn, Fyn, and Syk kinases. Additionally, PD1 suppressed pro-inflammatory cytokine production by inhibiting the activity of critical transcription factor; nuclear factor-κB. These findings suggest that PD1, a bioactive lipid derived from DHA, is a very promising therapeutic candidate for mast cell-derived allergic inflammation. © 2025 ⓘ Yoon, Jieun; Kim, Daheen; Jeong, Na-Hee; Choi, Young-Ae; Kwon, Taeg Kyu; Lee, Soyoung; Khang, Dongwoo; Kim, Sang-Hyun ⓘ CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea; Department of Immunology, School of Medicine, Keimyung University, Daegu, 42601, South Korea; Department of Innovative Pharmaceutical Sciences, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, 41566, South Korea; Department of Gachon Advanced Institute for Health Science & Technology (GAIHST), Lee Gil Ya Cancer and Diabetes Institute, and Department of Physiology, College of Medicine, Gachon University, Incheon, 21999, South Korea; CMRI, Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, 41944, South Korea ⓘ ⓘ 59740726300; 59740726400; 57194410234; 7404777420; 7202206057; 8537269200; 26039177500; 57210450420 ⓘ sy.lee@knu.ac.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 187 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ Allergic inflammation; FcεRⅠ signaling; Mast cells; Omega-3 fatty acids; Protectin D1 ⓘ Anaphylaxis; Animals; Cell Degranulation; Disease Models, Animal; Docosahexaenoic Acids; Hypersensitivity; Immunoglobulin E; Inflammation; Male; Mast Cells; Mice; Mice, Inbred BALB C; Ovalbumin; Passive Cutaneous Anaphylaxis; Rats; Receptors, IgE; Signal Transduction; ap 001; docosahexaenoic acid; Evans blue; histamine; immunoglobulin E; interleukin 4; ovalbumin; protein kinase Syk; ap 001; docosahexaenoic acid; immunoglobulin E; immunoglobulin E receptor; allergic inflammation; animal cell; animal experiment; animal model; animal tissue; Article; bone marrow; calcium cell level; calcium transport; cell viability; controlled study; cytokine production; degranulation; degranulation assay; ear edema; enzyme linked immunosorbent assay; hypothermia; male; mast cell; mast cell degranulation; mouse; nonhuman; passive skin anaphylaxis; RBL-2H3 cell line; signal transduction; systemic anaphylaxis; Western blotting; anaphylaxis; animal; Bagg albino mouse; blood; disease model; drug effect; drug therapy; hypersensitivity; immunology; inflammation; metabolism; rat ⓘ English Final 2025 10.1016/j.biopha.2025.118060 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Restoration of intestinal barrier function by fexuprazan, a potassium-competitive acid blocker, in Caco-2 cells and its higher gastrointestinal distribution in rats ⓘ This study aimed to investigate the efficacy of fexuprazan in restoring intestinal barrier function in comparison with other potassium-competitive acid blockers (P-CABs) and esomeprazole. The effect of fexuprazan on trans-epithelial electrical resistance (TEER) value, mRNA and protein expression of tight junction genes, and cell morphology was investigated using a dextran sulfate sodium (DSS)-induced ulcerative colitis Caco-2 cell model. Treatment with fexuprazan, esomeprazole, tegoprazan, and vonoprazan significantly increased TEER values in a 3 % DSS-induced ulcerative colitis Caco-2 cells in a concentration-dependent manner. The TEER value-concentration profile showed sigmoidal shape curves and yielded half maximal effective concentration of 0.983 – 1.17 μg/mL for P-CABs and 3.27 μg/mL for esomeprazole. Among these drugs, fexuprazan showed the highest activity in the restoring intestinal barrier function. Fexuprazan also increased the expression of tight junction genes including zonula occludens-1, claudin 1, occludin, and mucin 1, and also thickened the epithelial cell membrane after treatment with 20 μg/mL fexuprazan. Fexuprazan showed a particularly high distribution in the liver and gastrointestinal tract in rats following oral administration of 2 mg/kg fexuprazan, which appears to be a positive characteristic of fexuprazan's effect on ulcerative colitis and gastric acid-related diseases although in vivo therapeutic efficacy of fexuprazan for ulcerative colitis requires further validation in both animal and human. In conclusion, fexuprazan can potentially restore intestinal barrier function by increasing the expression of tight junction genes and by strengthening the cell membrane integrity in DSS-induced colitis model. © 2025 The Authors ⓘ Jeon, Ji-Hyeon; Lee, Jihoon; Baek, Yeon-Ju; Lim, Kwon-Jo; Kim, Ji Duck; Park, Joon Seok; Choi, Min-Koo; Song, Im-Sook ⓘ College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea, Vessel‑Organ Interaction Research Center (VOICE) and BK21 FOUR Community‑Based Intelligent Novel Drug Discovery Education Unit, Kyungpook National University, Daegu, 41566, South Korea; College of Pharmacy, Dankook University, Cheon‑an, 31116, South Korea; Life Science Institute, Daewoong Pharmaceutical, Gyeonggido, Yongin, 17028, South Korea; Life Science Institute, Daewoong Pharmaceutical, Gyeonggido, Yongin, 17028, South Korea; Life Science Institute, Daewoong Pharmaceutical, Gyeonggido, Yongin, 17028, South Korea; College of Pharmacy, Dankook University, Cheon‑an, 31116, South Korea; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 41566, South Korea, Vessel‑Organ Interaction Research Center (VOICE) and BK21 FOUR Community‑Based Intelligent Novel Drug Discovery Education Unit, Kyungpook National University, Daegu, 41566, South Korea ⓘ ⓘ 57204685946; 57195979045; 59234812100; 59909855500; 59909703800; 57755131400; 8695781400; 7201564500 ⓘ isssong@knu.ac.kr; ⓘ Biomedicine and Pharmacotherapy ⓘ BIOMED PHARMACOTHER ⓘ 0753-3322 1950-6007 188 SCIE MEDICINE, RESEARCH & EXPERIMENTAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-06-11 ⓘ 0 ⓘ ⓘ Fexuprazan; Tight junction genes; Tissue distribution; Trans-epithelial electrical resistance; Ulcerative colitis ⓘ Animals; Caco-2 Cells; Colitis, Ulcerative; Dextran Sulfate; Electric Impedance; Esomeprazole; Humans; Intestinal Barrier Function; Intestinal Mucosa; Male; Proton Pump Inhibitors; Pyrroles; Rats; Rats, Sprague-Dawley; Tight Junction Proteins; Tight Junctions; claudin 1; esomeprazole; fexuprazan; messenger RNA; mucin 1; occludin; protein ZO1; tegoprazan; vonoprazan; dextran sulfate; esomeprazole; proton pump inhibitor; pyrrole derivative; tight junction protein; adult; animal experiment; animal tissue; Article; Caco-2 cell line; cell membrane; cell structure; cell viability; comparative study; concentration response; controlled study; dextran sulfate sodium-induced ulcerative colitis; drug absorption; drug distribution; drug efficacy; drug tissue level; EC50; gastrointestinal tract; gene expression; human; human cell; in vitro study; in vivo study; intestinal barrier function; intestine epithelium cell; liver; male; mRNA expression level; nonhuman; protein expression level; rat; stomach acid; tight junction; transepithelial resistance; animal; drug effect; drug therapy; genetics; impedance; intestinal barrier function; intestine mucosa; metabolism; Sprague Dawley rat; ulcerative colitis ⓘ English Final 2025 10.1016/j.biopha.2025.118185 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ The inhibition of endothelial DLL4-NOTCH1 signaling by 2'-hydroxyflavanone enhances anti-PD-1 therapy in melanoma ⓘ Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapeutics; however limited patient responses necessitate combination strategies to improve therapeutic efficacy. Among potential combination partners, drugs targeting DLL4-NOTCH1 signaling pathway-a critical regulator of vascular function-show promise as angiogenesis modulators, but their clinical development have been hindered by safety concerns. To address this challenge, we adopted a novel approach by screening natural compounds with a long history of human consumption. Building upon our earlier findings, we identified three inhibitors of DLL4-NOTCH1 signaling: steppogenin, sanggenon F, and dehydrovomifoliol. Steppogenin inhibited both DLL4 and NOTCH1 activities, while sanggenon F and dehydrovomifoliol selectively suppressed DLL4 and NOTCH1 activity, respectively. We assessed their impact on key angiogenic processes, including endothelial cell migration, sprouting, and proliferation, and elucidated the relative contributions of selective DLL4 or NOTCH1 inhibition to the anti-angiogenic effect. By comparing structurally similar compounds, we identified the 2'-hydroxyflavanone moiety as a key element for DLL4 inhibition. Notably, combining steppogenin with an ICI demonstrated that a nature-derived angiogenesis inhibitor can boost the anti-cancer effect of ICI in a mouse melanoma allograft model. This comprehensive analysis of structure-activity relationships and in vivo therapeutic evaluation provides valuable insights into the development of novel anti-angiogenic compounds for combination therapy with ICIs in cancer treatment. ⓘ You, Jihye; Ha, Seunghwan; Kim, Doyoung; Kim, Hyoung-Geun; Kim, Se Ha; Jeong, Ji-Hak; Oh, Changmin; Baek, Nam-In; Jung, Jong Hwa; Kim, Jeong Ah; Lee, You Mie ⓘ Kyungpook Natl Univ, Coll Pharm, Vessel Organ Interact Res Ctr, VOICE MRC, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm & Res Inst Pharmaceut Sci, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu 41566, South Korea; Kyung Hee Univ, Grad Sch Biotechnol, Yongin 17104, South Korea; Kyung Hee Univ, Dept Oriental Med Biotechnol, Yongin 17104, South Korea ⓘ Kim, Jeong-ah/Q-2453-2016; Baek, Nam-In/AAK-7447-2020 ⓘ 59215293600; 59215150400; 56802861000; 57192300072; 59215150500; 55913671500; 58665396400; 57214954753; 57205171942; 57920359700; 8230508600 ⓘ lym@knu.ac.kr; ⓘ ARCHIVES OF PHARMACAL RESEARCH ⓘ ARCH PHARM RES ⓘ 0253-6269 1976-3786 48 4 SCIE CHEMISTRY, MEDICINAL;PHARMACOLOGY & PHARMACY ⓘ 2024 7.5 5.3 0 2025-05-07 ⓘ 0 0 2'-Hydroxyflavanone; DLL4-NOTCH1 signaling pathway; Immune checkpoint inhibitors; Vascular normalization ⓘ ANTI-ANGIOGENIC THERAPY; CANCER; EFFICACY; SAFETY; EXPRESSION; CELLS; DLL4 ⓘ 2'-Hydroxyflavanone; DLL4-NOTCH1 signaling pathway; Immune checkpoint inhibitors; Vascular normalization ⓘ Adaptor Proteins, Signal Transducing; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Synergism; Flavanones; Humans; Immune Checkpoint Inhibitors; Melanoma; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Receptor, Notch1; Signal Transduction; 3' o methyltaxifolin; angiogenic protein; dehydrovomifoliol; delta like 4 protein; eriodictyol; flavanone derivative; immune checkpoint inhibitor; liquiritigenin; lyoniresinol; moracin E; naringenin; Notch1 receptor; panaxytriol; programmed death 1 receptor antibody; sanggenol O; sanggenon F; sesamolin; steppogenin; unclassified drug; 2'-hydroxyflavanone; calcium binding protein; DLL4 protein, human; flavanone derivative; immune checkpoint inhibitor; NOTCH1 protein, human; Notch1 receptor; PDCD1 protein, human; programmed death 1 receptor; signal transducing adaptor protein; animal cell; animal experiment; animal model; animal tissue; antiangiogenic activity; antineoplastic activity; Article; B16-F10 cell line; cancer graft; cancer inhibition; cell migration; cell proliferation; checkpoint inhibitor therapy; controlled study; drug identification; drug potentiation; drug screening; drug selectivity; drug structure; EA.hy 926 cell line; endothelium cell; ginseng; Glycyrrhiza glabra; human; human cell; in vitro study; in vivo study; melanoma; molecular docking; Morus alba; mouse; nonhuman; signal transduction; sprouting angiogenesis; structure activity relation; tumor hypoxia; tumor vascularization; animal; C57BL mouse; cell motion; chemistry; dose response; drug effect; drug therapy; melanoma; metabolism; pathology; signal transduction; tumor cell line ⓘ English 2025 2025-04 10.1007/s12272-025-01539-z ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Time splitting method for nonlinear Schrodinger equation with rough initial data in L² ⓘ We establish convergence results related to the operator splitting scheme on the Cauchy problem for the nonlinear Schr & ouml;dinger equation with rough initial data in L-2, {i partial derivative(t)u + Delta u = lambda|u|(p )u, (x, t) is an element of R(d )x R+, u(x, 0) = phi(x), x is an element of R-d, where lambda is an element of {-1,1} and p > 0. While the Lie approximation ZL is known to converge to the solution u when the initial datum phi is sufficiently smooth, the convergence result for rough initial data is open to question. In this paper, for rough initial data phi is an element of L-2(R-d), we prove the L-2 convergence of the filtered Lie approximation Z (flt) to the solution u in the mass-subcritical range, 0 < p < 4/d. Furthermore, we provide a precise convergence result for radial initial data phi is an element of L-2(R-d). ⓘ Choi, Hyung Jun; Kim, Seonghak; Koh, Youngwoo ⓘ Korea Univ Technol & Educ, Sch Liberal Arts, Cheonan 31253, South Korea; Kyungpook Natl Univ, Coll Nat Sci, Dept Math, Daegu 41566, South Korea; Kongju Natl Univ, Dept Math Educ, Kong Ju 32588, South Korea ⓘ ⓘ 55780425800; 56489490600; 56729929100 ⓘ hjchoi@koreatech.ac.kr; shkim17@knu.ac.kr; ywkoh@kongju.ac.kr; ⓘ JOURNAL OF DIFFERENTIAL EQUATIONS ⓘ J DIFFER EQUATIONS ⓘ 0022-0396 1090-2732 417 SCIE MATHEMATICS ⓘ 2024 2.3 5.3 0 2025-05-07 ⓘ 0 0 Nonlinear Schrodinger equations; Time splitting method ⓘ HIGH-ORDER; LOW REGULARITY; FOURIER INTEGRATOR; SCHEMES; CONVERGENCE; APPROXIMATION ⓘ Nonlinear Schrödinger equations; Time splitting method ⓘ ⓘ English 2025 2025-02-05 10.1016/j.jde.2024.11.018 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ Time-/environment-dependent multilevel optical encryption through photoluminescence enhancement of perovskite quantum dot/polymer composite via silver epoxy paste ⓘ Perovskite quantum dot (PQD)/polymer nanocomposites have garnered significant attention in the field of advanced optical encryption due to their eminent photoluminescence (PL) properties and stability. Nonetheless, the strategies introduced often necessitate sophisticated experimental setup, presenting challenges for the practical application. Herein, we have designed a time/environment-dependent optical encryption methodology which leverages the PL enhancement of cesium lead bromide (CsPbBr3) PQD/polydimethylsiloxane (PDMS) film through the application of silver (Ag) epoxy paste (AEP). Following heat treatment under vacuum after AEP application on the film surface, diffused Ag ​+ ​ions efficiently passivated the surface defects of CsPbBr3 PQDs, leading to an enhanced quantum yield of 20.7 ​%. AEP treatment was further exploited as a multilevel encryption technique by modulating the treatment and environmental conditions. Encrypted information was initially concealed under daylight and masked by fictitious information under UV light. This information was decrypted over time, exhibiting variances in PL intensity as quenching progresses. To prevent information leakage, the decrypted information could be reverted to the fictitious information via a rapid quenching of the AEP-treated film in aqueous environment. This research not only paves a new pathway toward an efficient defect passivation strategy for PQDs but also advances a straightforward, yet sophisticated optical encryption strategy. © 2025 Chongqing University ⓘ Ryu, Jaehyeok; Lee, Jiyeon; Kim, Dongjun; Lee, Yu Jin; Kim, Ji Heon; Oh, Juwon; Kim, Jiwon ⓘ School of Integrated Technology, College of Computing, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea; School of Integrated Technology, College of Computing, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea; School of Integrated Technology, College of Computing, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea; Department of Chemistry, College of Science, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea; Department of Chemistry, College of Natural Science, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Department of Chemistry, College of Natural Science, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; School of Integrated Technology, College of Computing, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea, Integrated Science and Engineering Division, Underwood International College, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea, Department of Integrative Biotechnology, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon, 21983, South Korea ⓘ ⓘ 58627667500; 57210790315; 57444705200; 57221072945; 59730163200; 55812113000; 57191681250 ⓘ jiwon.kim@yonsei.ac.kr; ⓘ Nano Materials Science ⓘ NANO MATER SCI ⓘ 2096-6482 2589-9651 ESCI MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY ⓘ 2024 17.9 5.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ Diffusion; Optical encryption; Perovskite quantum dot/polymer nanocomposite; Photoluminescence; Silver epoxy paste; Surface defect passivation ⓘ Conducting polymers; Elastomers; Laser beams; Nanocomposite films; Photoluminescence; Polydimethylsiloxane; Rapid quenching; Defect passivation; Epoxy pastes; Multilevels; Optical encryption; Perovskite quantum dot/polymer nanocomposite; Photoluminescence enhancement; Polymer nanocomposite; Polymer-nanocomposite; Silver epoxy paste; Surface defect passivation; Nanocrystals ⓘ English Article in press 2025 10.1016/j.nanoms.2025.03.004 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ A clinical feasibility study of a photoacoustic finder for sentinel lymph node biopsy in breast cancer patients: A prospective cross-sectional study ⓘ The sentinel lymph node (SLNb) is generally performed using radioisotopes, blue dyes, or both to improve false negative rate. However, ionizing radiation is involved in a gamma probe with radioisotopes and the blue dye detection relies on native visual inspection by an operator. To overcome these limitations, we developed the photoacoustic finder (PAF), a highly sensitive, non-radioactive detector that uses only blue dye and a photoacoustic signal to detect SLNs. A total of 121 patients with breast cancer were enrolled, and 375 lymph nodes were excised using conventional SLNb. The PAF was used to measure the signal from the excised lymph nodes. We compared the SLN detection rates of each method (gamma probe, visual inspection, and PAF) and conducted a non-inferiority test. The PAF detected 87 % of SLNs, comparable to the gamma probe (85 %) and superior to visual inspection (73 %). Non-inferiority tests confirmed PAF's performance was not inferior to visual inspection (p < 0.001) or the gamma probe (p < 0.015). Using the dual-modal method (gamma probe + visual inspection) as the gold standard, PAF showed a sensitivity of 0.81 and specificity of 0.63. This study demonstrates that PAF, using only blue dye, offers a non-inferior alternative to the standard dual-modal SLN detection method with radioactive materials, opening new avenues for radiation-free SLNb in the future. ⓘ Han, Moongyu; Lee, Young Joo; Ahn, Junho; Nam, Sunghun; Kim, Minseong; Park, Jeongwoo; Ahn, Joongho; Ryu, Hanyoung; Seo, Youngseok; Park, Byullee; Kim, Dooreh; Kim, Chulhong ⓘ Pohang Univ Sci & Technol, Med Device Innovat Ctr, Dept Convergence IT Engn Elect Engn Mech Engn & Me, 77 Cheongam Ro, Pohang 37673, South Korea; Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Dept Surg, 222 Banpo Daero, Seoul 06591, South Korea; WONTECH Co Ltd, R&D Ctr, Techno 8 Ro, Daejeon 34028, South Korea; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Sungkyunkwan Univ, Inst Quantum Biophys Metabiohealth Biopharmaceut C, Dept Biophys, Suwon 16419, South Korea ⓘ Park, Jeongwoo/LIC-1971-2024; Lee, Young Joo/ITV-7221-2023 ⓘ 57217630442; 58019185800; 59148166900; 59148269900; 59148685800; 57205588351; 57194204029; 57211519282; 57211518733; 57200376082; 57215816754; 57202234822 ⓘ dalgyu0820@postech.ac.kr; nofearyjbr@gmail.com; jhahn60@postech.ac.kr; shnam180260@postech.ac.kr; tjdgus3822@postech.ac.kr; jwpark@knu.ac.kr; joongho.ahn@postech.ac.kr; hyryu@wtlaser.com; physys@wtlaser.com; byullee@skku.edu; rlaenfpd@gmail.com; chulhong@postech.edu; ⓘ PHOTOACOUSTICS ⓘ PHOTOACOUSTICS ⓘ 2213-5979 43 SCIE ENGINEERING, BIOMEDICAL;INSTRUMENTS & INSTRUMENTATION;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING ⓘ 2024 6.8 5.4 0 2025-05-07 ⓘ 2 3 Non-radioactive sentinel lymph node detection; Sentinel lymph node biopsy; Photoacoustic; Photoacoustic finder ⓘ NEAR-INFRARED FLUORESCENCE; INDOCYANINE GREEN; CONTRAST AGENTS; PRACTICAL GUIDE; ULTRASOUND; TOMOGRAPHY; BLUE; MICROSCOPY; DYES ⓘ Non-radioactive sentinel lymph node detection; Photoacoustic; Photoacoustic finder; Sentinel lymph node biopsy ⓘ Gamma rays; Ion bombardment; Radioactive tracers; Blue dyes; Breast Cancer; Lymph node; Lymph node detections; Non-inferiority; Non-radioactive sentinel lymph node detection; Photoacoustic finder; Sentinel lymph node biopsies; Sentinel lymph nodes; Visual inspection; Probes ⓘ English 2025 2025-06 10.1016/j.pacs.2025.100716 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Article ⓘ First- and second-language subtitles and cognitive load: An EEG study ⓘ Empirical evidence remains sparse about how videos enhanced with first-language (L1) and second-language (L2) subtitles influence cognitive load in L2 learners. To address this point, 25 Korean undergraduate students were exposed to six short videos: baseline, L1-subtitled, and L2-subtitled videos at both high and low difficulty levels (determined by linguistic complexity and speech rate). Baseline videos included subtitles in Arabic, a language unfamiliar to the participants. As participants viewed the videos, their brains' electrical activity was recorded using electroencephalography (EEG). After each video, participants completed a self-report questionnaire based on the video they had just watched. Analyses of the EEG data and questionnaire responses consistently suggested that, compared to baseline videos, L1-subtitled videos reduce cognitive load in L2 learners. However, findings for L2-subtitled videos were less consistent. While the EEG results indicated no significant difference in cognitive load between L2-subtitled and baseline videos, participants reported significantly higher cognitive effort for baseline videos than for L2-subtitled videos. Notably, these results did not vary according to the difficulty levels of the videos. ⓘ Lee, Taegang; Lee, Yoonhyoung; Choi, Sungmook ⓘ Kyungpook Natl Univ, Daegu, South Korea; Yeungnam Univ, Dept Psychol, Yeungnam, South Korea ⓘ ⓘ ⓘ dnslrofh48@knu.ac.kr; yoonhyoung@gmail.com; sungmookchoi@knu.ac.kr; ⓘ LANGUAGE LEARNING & TECHNOLOGY ⓘ LANG LEARN TECHNOL ⓘ 1094-3501 29 1 SSCI EDUCATION & EDUCATIONAL RESEARCH;LINGUISTICS ⓘ 2024 4.1 5.4 ⓘ 0 Subtitles; EEG; Cognitive Load; Multimedia-Assisted Language Learning ⓘ WORKING-MEMORY; SPLIT-ATTENTION; CAPTIONED VIDEO; MULTIMEDIA; THETA; COMPREHENSION; OSCILLATIONS; L1 ⓘ ⓘ ⓘ English 2025 2025 ⓘ 바로가기 바로가기
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