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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites | BackgroundTransmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of metabolisms.MethodsHere, we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites (MLCSs), using in vitro cells and in vivo animal systems, via approaches by immunofluorescence, proximity labelling based proteomics analysis, organelle reconstitution etc.ResultsUpon extracellular glucose repletion following depletion, TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8 (FKBP8) and lysosomal TM4SF5. Proximity labeling showed molecular clustering of phospho-dynamic-related protein I (DRP1) and certain mitophagy receptors at TM4SF5-enriched MLCSs, leading to mitochondrial fission and autophagy. TM4SF5 bound NPC intracellular cholesterol transporter 1 (NPC1) and free cholesterol, and mediated export of lysosomal cholesterol to mitochondria, leading to impaired oxidative phosphorylation but intact tricarboxylic acid (TCA) cycle and beta-oxidation. In mouse models, hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria, both with positive relations to liver malignancy.ConclusionsOur findings suggested that TM4SF5-enriched MLCSs regulate glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming, presumably while hepatocellular carcinogenesis, recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial reprogramming to support biomolecule synthesis in addition to glycolytic energetics. | Kim, Ji Eon; Park, So-Young; Kwak, Chulhwan; Lee, Yoonji; Song, Dae-Geun; Jung, Jae Woo; Lee, Haesong; Shin, Eun-Ae; Pinanga, Yangie; Pyo, Kyung-hee; Lee, Eun Hae; Kim, Wonsik; Kim, Soyeon; Jun, Chang-Duck; Yun, Jeanho; Choi, Sun; Rhee, Hyun-Woo; Liu, Kwang-Hyeon; Lee, Jung Weon | Seoul Natl Univ, Coll Pharm, Dept Pharm, Seoul, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Seoul, South Korea; Kyungpook Natl Univ, Coll Pharm, Based Intelligent Novel Drug Discovery Educ Unit, FOUR Community BK21, Daegu, South Korea; Seoul Natl Univ, Dept Chem, Seoul, South Korea; Chung Ang Univ, Coll Pharm, Seoul, South Korea; Korea Inst Sci & Technol KIST, Nat Prod Informat Res Ctr, Gangwon Do, Gangneung Si, South Korea; Gwangju Inst Sci & Technol GIST, Sch Life Sci, Gwangju, South Korea; Dong A Univ, Coll Med, Dept Biochem, Pusan, South Korea; Ewha Womans Univ, Coll Pharm, Global AI Drug Discovery Ctr, Seoul, South Korea; Seoul Natl Univ, Interdisciplinary Program Genet Engn, Seoul, South Korea; Seoul Natl Univ, Coll Pharm, Dept Pharm, Seoul 08826, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Based Intelligent Novel Drug Discovery Educ Unit, Daegu 41566, South Korea | LEE, YOONJI/AAU-7878-2021; Kim, Ji Eon/LTE-3474-2024; Choi, Sun/AAQ-9407-2020; Rhee, Hyun-Woo/AAS-4268-2021; Lee, Jung Weon/F-9149-2012 | 57191344143; 57211630074; 35940010600; 16836651600; 24503655800; 57213798625; 57203967203; 57196061216; 57354046400; 58028968400; 58028765300; 58028866000; 58548802100; 7103018249; 9238000400; 8659831000; 35734943800; 55768214700; 25825131800 | dstlkh@knu.ac.kr;jwl@snu.ac.kr; | CANCER COMMUNICATIONS | CANCER COMMUN | 2523-3548 | 44 | 1 | SCIE | ONCOLOGY | 2024 | 24.9 | 3.5 | 3.14 | 2025-04-16 | 6 | 6 | cholesterol; fluorescent imaging; glucose catabolism; hepatocellular carcinogenesis; membrane contact sites; mitochondria function; mitophagy; oxidative phosphorylation; protein-protein interaction; tetraspanin | EPITHELIAL-MESENCHYMAL TRANSITION; MOLECULAR-INTERACTIONS; TETRASPAN(IN) TM4SF5; BINDING; COMMUNICATION; TRANSPORTERS; ACTIVATION; DYNAMICS | cholesterol; fluorescent imaging; glucose catabolism; hepatocellular carcinogenesis; membrane contact sites; mitochondria function; mitophagy; oxidative phosphorylation; protein-protein interaction; tetraspanin | Animals; Cell Movement; Cholesterol; Lysosomes; Membrane Proteins; Mice; Mitochondria; cholesterol; glucose; cholesterol; membrane protein; TM4SF5 protein, mouse; animal experiment; animal model; animal tissue; Article; autophagy (cellular); bicinchoninic acid assay; carcinogenesis; cell growth assay; cell isolation; citric acid cycle; controlled study; correlation coefficient; energy transfer; gene expression; gene ontology; genetic transfection; glycolysis; HEK293-FT cell line; Huh-7 cell line; human; human cell; immunoblotting; immunofluorescence; immunofluorescence assay; immunohistochemistry; immunoprecipitation; in vitro study; in vivo study; lipidomics; live cell imaging; liver cancer; liver cell; liver cell carcinoma; lysosome; male; mitochondrion; mitophagy; molecular docking; mouse; mouse model; nonhuman; optical density; oxidative phosphorylation; protein fingerprinting; proteomics; real time reverse transcription polymerase chain reaction; RNA extraction; transmission electron microscopy; Western blotting; animal; cell motion; genetics; lysosome; metabolism; physiology | English | 2024 | 2024-01 | 10.1002/cac2.12510 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Letter | IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells | Noh, Soojeong; Ryu, Suyeon; Jung, Dokyung; Shin, Sanghee; Jung, Inseong; Kang, Sung-Min; Kim, Christine Seulki; Choi, Sung-Jin; Cho, Hanchae; Schwammle, Melanie; Jeong, Youngtae; Bucher, Felicitas; Choi, Il-Kyu; Lee, Shin Yup; Im, Sin-Hyeog; Yea, Kyungmoo; Baek, Moon-Chang | DGIST, Dept New Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst CMRI, Sch Med, Dept Mol Med, Daegu, South Korea; Kyungpook Natl Univ, Dept Mol Med, Daegu, South Korea; Univ Freiburg, Fac Biol, Freiburg, Germany; Univ Freiburg, Fac Med, Eye Ctr, Med Ctr, Freiburg, Germany; DGIST, New Biol Res Ctr, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Lung Canc Ctr, Daegu, South Korea; Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea | Choi, Sung-Jin/ACC-8335-2022; Im, Sin-Hyeog/AAM-9586-2021 | 57223308415; 59787801600; 57207487580; 57202494417; 57223306535; 59499667300; 57209806970; 57435770900; 57184674000; 57219661375; 56151139100; 37057078400; 59525944000; 49863712700; 55583814300; 12769131100; 7006013097 | ykm31@dgist.ac.kr;mcbaek@knu.ac.kr; | CANCER COMMUNICATIONS | CANCER COMMUN | 2523-3548 | 44 | 12 | SCIE | ONCOLOGY | 2024 | 24.9 | 3.5 | 0 | 2025-05-07 | 1 | 1 | chimeric antigen receptor; interleukin 2; mitogen activated protein kinase 3; programmed death 1 ligand 1; angiogenesis; apoptosis; B16-F10 cell line; cancer cell; CD8+ T lymphocyte; cell activation; coculture; cytotoxic T lymphocyte; cytotoxicity; down regulation; epithelial mesenchymal transition; exosome; flow cytometry; gene; gene expression; human; human cell; immunoblotting; immunocompetent cell; immunocytochemistry; immunofluorescence; immunohistochemistry; immunoprecipitation; immunosuppressive treatment; immunosurveillance; internalization (cell); Letter; melanoma; melanoma cell; metastasis; mouse; neutralization test; nonhuman; PD-L1 gene; protein expression; protein phosphorylation; tumor growth; tumor microenvironment; tumor volume; tumor xenograft; upregulation; Western blotting; immune deficiency; letter | English | 2024 | 2024-12 | 10.1002/cac2.12623 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Neural mechanisms of acceptance-commitment therapy for obsessive-compulsive disorder: a resting-state and task-based fMRI study | BackgroundThere is growing evidence for the use of acceptance-commitment therapy (ACT) for the treatment of obsessive-compulsive disorder (OCD). However, few fully implemented ACT have been conducted on the neural mechanisms underlying its effect on OCD. Thus, this study aimed to elucidate the neural correlates of ACT in patients with OCD using task-based and resting-state functional magnetic resonance imaging (fMRI).MethodsPatients with OCD were randomly assigned to the ACT (n = 21) or the wait-list control group (n = 21). An 8-week group-format ACT program was provided to the ACT group. All participants underwent an fMRI scan and psychological measurements before and after 8 weeks.ResultsPatients with OCD showed significantly increased activation in the bilateral insula and superior temporal gyri (STG), induced by the thought-action fusion task after ACT intervention. Further psycho-physiological interaction analyses with these regions as seeds revealed that the left insular-left inferior frontal gyrus (IFG) connectivity was strengthened in the ACT group after treatment. Increased resting-state functional connectivity was also found in the posterior cingulate cortex (PCC), precuneus, and lingual gyrus after ACT intervention Most of these regions showed significant correlations with ACT process measures while only the right insula was correlated with the obsessive-compulsive symptom measure.ConclusionsThese findings suggest that the therapeutic effect of ACT on OCD may involve the salience and interoception processes (i.e. insula), multisensory integration (i.e. STG), language (i.e. IFG), and self-referential processes (i.e. PCC and precuneus). These areas or their interactions could be important for understanding how ACT works psychologically. | Lee, Sang Won; Kim, Seungho; Lee, Sangyeol; Seo, Ho Seok; Cha, Hyunsil; Chang, Yongmin; Lee, Seung Jae | Kyungpook Natl Univ, Chilgok Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Psychiat, Daegu, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu, South Korea | Lee, Dae Young/ADO-9686-2022; Lee, Seung/AAI-1191-2020 | 55820414800; 57218284791; 57875786900; 58490189000; 57189728122; 7501840633; 58509400200 | jayleemd@knu.ac.kr;ychang@knu.ac.kr; | PSYCHOLOGICAL MEDICINE | PSYCHOL MED | 0033-2917 | 1469-8978 | 54 | 2 | SSCI;SCIE | PSYCHOLOGY, CLINICAL;PSYCHOLOGY;PSYCHIATRY | 2024 | 5.5 | 3.5 | 4.48 | 2025-05-07 | 8 | 11 | Acceptance-commitment therapy; cognitive defusion; functional connectivity; mindfulness; obsessive-compulsive disorder; thought-action fusion | THOUGHT-ACTION FUSION; COGNITIVE FUSION; FUNCTIONAL NEUROANATOMY; PSYCHOMETRIC PROPERTIES; EXPERIENTIAL AVOIDANCE; ACTION QUESTIONNAIRE; DEFAULT MODE; METAANALYSIS; MEDITATION; MINDFULNESS | Acceptance-commitment therapy; cognitive defusion; functional connectivity; mindfulness; obsessive-compulsive disorder; thought-action fusion | Brain; Brain Mapping; Gyrus Cinguli; Humans; Magnetic Resonance Imaging; Obsessive-Compulsive Disorder; Prefrontal Cortex; brain; brain mapping; cingulate gyrus; controlled study; diagnostic imaging; human; nuclear magnetic resonance imaging; obsessive compulsive disorder; prefrontal cortex; procedures; randomized controlled trial | English | 2024 | 2024-01 | 10.1017/s0033291723001769 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Letter | Positive regulation of cell proliferation by the miR-1290-EHHADH axis in hepatocellular carcinoma | Lee, Jinkwon; Kim, Gyeonghwa; Han, Tae-Su; Jung, Eunsun; Son, Taesang; Kim, Kwangho; Kwon, Kiyoon; Roh, Yuna; Ryu, Tae Young; Tae, In Hwan; Kang, Yunsang; Lee, Byungheon; Lee, Yu Rim; Park, Soo Young; Tak, Won Young; Kim, Dae-Soo; Son, Mi-Young; Hur, Keun; Cho, Hyun-Soo | Korea Res Inst Biosci & Biotechnol, Stem Cell Convergence Res Ctr, Daejeon 34141, South Korea; Korea Univ Sci & Technol, Dept Biosci, Daejeon, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Taegu 41944, South Korea; Sungkyunkwan Univ, Dept Biol Sci, Suwon, South Korea; Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu, South Korea | Kim, Young Hoon/F-5424-2012; Kim, Gyeonghwa/AAQ-6424-2021; Hur, Keun/G-9513-2011 | 57226003200; 57195957884; 26424339800; 57205182220; 57903705000; 57200561661; 58951881900; 57988609400; 57204715311; 58952051500; 58196020400; 16304374900; 57194094753; 57191674344; 7004074582; 8056858000; 7004301289; 8861888000; 56508722000 | kds2465@kribb.re.kr;myson@kribb.re.kr;KeunHur@knu.ac.kr;chohs@kribb.re.kr; | CANCER COMMUNICATIONS | CANCER COMMUN | 2523-3548 | 44 | 6 | SCIE | ONCOLOGY | 2024 | 24.9 | 3.5 | 1.46 | 2025-05-07 | 4 | 3 | Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; MicroRNAs; biological marker; enoyl coa hydratase 3 hydroxyacyl coa dehydrogenase; glyceraldehyde 3 phosphate dehydrogenase; microRNA; microRNA 1290; transcription factor EZH2; unclassified drug; adult; cancer prognosis; cancer staging; carcinogenesis; cell proliferation; colorectal cancer; controlled study; CRISPR-CAS9 system; female; gene ontology; gene overexpression; glioma; human; human cell; Letter; liver cell carcinoma; liver cirrhosis; luciferase assay; lung cancer; major clinical study; middle aged; mouse; nonalcoholic fatty liver; nonhuman; protein expression; upregulation; animal; gene expression regulation; genetics; liver cell carcinoma; liver tumor; pathology; tumor cell line | English | 2024 | 2024-06 | 10.1002/cac2.12536 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||||
| ○ | ○ | Article | Solar PV Generation Prediction Based on Multisource Data Using ROI and Surrounding Area | This study introduces a lightweight hybrid solar photovoltaic (PV) generation prediction model operating on 1-h intervals, utilizing remote sensing data to enhance power grid management. Multisource remote sensing data, including spatial features from infrared satellite images and temporal data from various hourly recorded datasets, capture spatiotemporal characteristics. The model defines and synthesizes regions of interest (ROI) and surrounding areas of ROI (ROIsurr ) within satellite images to reduce computational load. Integration of image and numerical weather prediction (NWP) process modules ensures accurate prediction. Comparative analysis against five machine learning algorithms shows significant improvements, with up to a 33.7% decrease in mean absolute error (MAE) and a 19.51% decrease in root mean square error (RMSE). Additionally, the model consistently meets ASHRAE Guideline 14 standards and outperforms single-source data models. Experimentation highlights the effectiveness of smaller ROIs in enhancing predictive accuracy, demonstrating adaptability to climate variations. This lightweight multisource remote sensing-based hybrid model promises to guide smart grid operations and sustainable power grid systems, advancing remote sensing applications in renewable energy management. | Kim, Bowoo; Suh, Dongjun | Kyungpook Natl Univ, Dept Convergence & Fus Syst Engn, Sangju 37224, South Korea | 57219947521; 36613529600 | kbw5913@knu.ac.kr;dongjunsuh@knu.ac.kr; | IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING | IEEE T GEOSCI REMOTE | 0196-2892 | 1558-0644 | 62 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2024 | 8.6 | 3.5 | 0 | 2025-04-16 | 0 | 1 | Satellite images; Predictive models; Spatiotemporal phenomena; Data models; Remote sensing; Power generation; Satellites; Convolutional neural network (CNN)-long short-term memory (LSTM); deep learning; lightweight; multisource data; region of interest (ROI); satellite image; solar photovoltaic (PV) generation forecasting; spatiotemporal | POWER-GENERATION; MODEL; OUTPUT | Convolutional neural network (CNN)-long short-term memory (LSTM); deep learning; lightweight; multisource data; region of interest (ROI); satellite image; solar photovoltaic (PV) generation forecasting; spatiotemporal | Image segmentation; Learning algorithms; Long short-term memory; Remote sensing; Satellites; Smart power grids; Solar power generation; Weather forecasting; CNN-LSTM; Deep learning; Lightweight; Multisource data; Power- generations; Predictive models; PV generation; Region-of-interest; Regions of interest; Remote-sensing; Satellite images; Solar PV generation forecasting; Solar PVs; Spatiotemporal; Spatiotemporal phenomenon; alternative energy; artificial neural network; forecasting method; learning; memory; photovoltaic system; power generation; prediction; remote sensing; satellite imagery; smart grid; solar power; spatiotemporal analysis; Mean square error | English | 2024 | 2024 | 10.1109/tgrs.2024.3392337 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | U-Net plus plus Based Subshallow Gas-Scattered Image Conditioning: Small-Scale Case Study of Seismic Data Acquired in the Korean East Sea | Data acquired through seismic surveys suffers from information loss for various reasons. Among these, shallow gas affects signals beneath it and causes distortion of seismic wave signals. These distorted signals often cause difficulties in interpreting seismic data. Various preceding research has been conducted to mitigate this issue, and this study presents an interpolation method using self-supervised machine learning. The dataset we use consists of small-scale marine seismic survey data acquired from the Youngil Bay near the eastern continental margin of the Korean Peninsula. The 2-D planes are randomly extracted from 3-D seismic data to generate training data of various sizes, which are then used to create an artificial neural network model. This study utilizes the U-Net++ architecture with an attention module to overcome the limitations associated with U-Net and to focus and emphasize repetitive patterns. In the training process, both the $L1$ loss function and the structural similarity index (SSIM) loss function are used as hybrid loss functions. This enables the network to recognize both the overall patterns of the data and the key patterns to focus on. The neural network model created through this study shows the successful performance in detecting patterns in the original data and interpolating missing values of seismic data. The output data generated through the proposed network improves stratigraphic continuity by interpolating the missing values of the original data and restoring the lost structure. | Lee, Juan; Lee, Min Je; Park, Hanjoon; Jun, Hyunggu; Cho, Yongchae | Seoul Natl Univ, Dept Energy Syst Engn, Seoul 00826, South Korea; Kyungpook Natl Univ, Dept Geol, Daegu 41566, South Korea; Seoul Natl Univ, Res Inst Energy & Resources, Dept Energy Syst Engn, Seoul 08826, South Korea | ; Park, Hanjoon/KIB-4675-2024; Cho, Yongchae/AAA-7647-2021; Jun, Hyunggu/ABT-7172-2022 | 58908499100; 58907889800; 57803661200; 56048061400; 55513719100 | smin3476@snu.ac.kr;minlee9683@snu.ac.kr;hanjoon67@snu.ac.kr;hgjun@knu.ac.kr;yc.cho@snu.ac.kr; | IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING | IEEE T GEOSCI REMOTE | 0196-2892 | 1558-0644 | 62 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2024 | 8.6 | 3.5 | 0.45 | 2025-04-16 | 2 | 3 | Interpolation; Surveys; Three-dimensional displays; Geology; Convolution; Computer architecture; Transforms; Attention module; interpolation; neural network; shallow gas; signal processing | TRACE INTERPOLATION; RECONSTRUCTION | Attention module; interpolation; neural network; shallow gas; signal processing | Korea; North Kyongsang; Pacific Ocean; Sea of Japan; South Korea; Yeongil Bay; Computer architecture; Geological surveys; Geophysical prospecting; Interpolation; Network architecture; Seismic response; Seismic waves; Signal processing; Spectral density; Stratigraphy; Supervised learning; Three dimensional displays; Attention module; Loss functions; Missing values; Neural-networks; Seismic datas; Seismic surveys; Shallow gas; Signal-processing; Small scale; Three-dimensional display; continental margin; data acquisition; data set; image analysis; interpolation; machine learning; numerical model; seismic data; seismic survey; seismic wave; signal processing; Neural networks | English | 2024 | 2024 | 10.1109/tgrs.2024.3366952 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Contagion dynamics in time-varying metapopulation networks with node's activity and attractiveness | The metapopulation network model is a mathematical framework used to study the spatial spread of epidemics with individuals' mobility. In this paper, we develop a time-varying network model in which the activity of a population is correlated with its attractiveness in mobility. By studying the spreading dynamics of the SIR (susceptible-infectious-recovered)-type disease in different correlated networks based on the proposed model, we theoretically derive the mobility threshold and numerically observe that increasing the correction between activity and attractiveness results in a reduced mobility threshold but suppresses the fraction of infected subpopulations. It also introduces greater heterogeneity in the spatial distribution of infected individuals. Additionally, we investigate the impact of nonpharmaceutical interventions on the spread of epidemics in different correlation networks. Our results show that the simultaneous implementation of self-isolation and self-protection is more effective in negatively correlated networks than that in positively correlated or non-correlated networks. Both self-isolation and self-protection strategies enhance the mobility threshold and, thus, slow down the spread of the epidemic. However, the effectiveness of each strategy in reducing the fraction of infected subpopulations varies in different correlated networks. Self-protection is more effective in positively correlated networks, whereas self-isolation is more effective in negatively correlated networks. Our study will provide insights into epidemic prevention and control in large-scale time-varying metapopulation networks. | Zeng, Lang; Tang, Ming; Liu, Ying; Yeop Yang, Seung; Do, Younghae | Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Dept Math, Daegu 41566, South Korea; East China Normal Univ, Sch Phys & Elect Sci, Shanghai 200241, Peoples R China; East China Normal Univ, Shanghai Key Lab Multidimens Proc, Shanghai 200241, Peoples R China; Southwest Petr Univ, Sch Comp Sci, Chengdu 610500, Peoples R China | ; Zeng, Lang/KLC-2236-2024; Do, Younghae/G-3522-2011 | 57219643973; 14421628700; 56641911300; 56589212300; 7103101109 | tangminghan007@gmail.com;yhdo@knu.ac.kr; | CHAOS | CHAOS | 1054-1500 | 1089-7682 | 34 | 5 | SCIE | MATHEMATICS, APPLIED;PHYSICS, MATHEMATICAL | 2024 | 3.2 | 3.6 | 1.07 | 2025-05-07 | 1 | 2 | Communicable Diseases; Epidemics; Humans; Population Dynamics; Time Factors; communicable disease; epidemic; human; population dynamics; time factor | English | 2024 | 2024-05 | 10.1063/5.0204497 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Low-frequency vibration and noise control in sandwiched composite locally resonant metamaterials-embedded structures | This study proposes a sandwiched composite locally resonant metamaterial (SLRM) system and SLRM-embedded plate structure (SLRMeP) to effectively control low-frequency vibrations and sound radiation. The wave control mechanism and configuration of the proposed system are more suitable and realistic to address practical lowfrequency vibro-acoustic problems. A numerical model was proposed based on the material properties, unit dimensions, and mass ratios to determine the local resonance characteristics and bandgap formation. The experimental results on a full-scale SLRMeP measuring 3000 x 4200 x 210 mm confirmed the efficacy of the local resonance bandgap for controlling vibrations and sound radiation, achieving a 94.08% reduction in the acceleration response and a 15.13 dB reduction in the sound pressure level. Additionally, variations in mass ratio, achieved by altering the mass density or dimensions, yield distinct bandgap behaviors, offering strategies to enhance vibro-acoustic performance. | Choi, Jewoo; In, Byung Wook; Hong, Taehoon; Lee, Dong-Eun; Cho, Tongjun; Park, Hyo Seon | Yonsei Univ, Dept Architectural Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea; Yonsei Univ, Engn Res Ctr, Seoul 120749, South Korea | ; Choi, Jewoo/MGT-4857-2025 | 57205453819; 59131960100; 57969349700; 56605563300; 56438830700; 55669886900 | tjcho@yonsei.ac.kr;hspark@yonsei.ac.kr; | DEVELOPMENTS IN THE BUILT ENVIRONMENT | DEV BUILT ENVIRON | 2666-1659 | 18 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2024 | 8.2 | 3.6 | 2.93 | 2025-05-07 | 10 | 11 | Acoustic metamaterial; Local resonance bandgap; Structural control; Low-frequency vibration; Noise; Plate structure | ELASTIC-WAVE ABSORPTION; BAND-GAPS; BEHAVIOR; PLATES | Acoustic metamaterial; Local resonance bandgap; Low-frequency vibration; Noise; Plate structure; Structural control | Acceleration; Acoustic fields; Acoustic generators; Acoustic noise; Acoustic properties; Acoustic wave scattering; Energy gap; Metamaterials; Plates (structural components); Structural dynamics; Vibrations (mechanical); % reductions; Acoustic metamaterial; Local resonance; Local resonance bandgap; Low-frequency vibration; Mass ratio; Noise; Plate structure; Sound radiations; Structural control; Acoustic wave propagation | English | 2024 | 2024-04 | 10.1016/j.dibe.2024.100457 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis | Targeting proximity-labeling enzymes to specific cellular locations is a viable strategy for profiling subcellular proteomes. Here, we generated transgenic mice (MAX-Tg) expressing a mitochondrial matrix-targeted ascorbate peroxidase. Comparative analysis of matrix proteomes from the muscle tissues showed differential enrichment of mitochondrial proteins. We found that reticulon 4-interacting protein 1 (RTN4IP1), also known as optic atrophy-10, is enriched in the mitochondrial matrix of muscle tissues and is an NADPH oxidoreductase. Interactome analysis and in vitro enzymatic assays revealed an essential role for RTN4IP1 in coenzyme Q (CoQ) biosynthesis by regulating the O-methylation activity of COQ3. Rtn4ip1-knockout myoblasts had markedly decreased CoQ9 levels and impaired cellular respiration. Furthermore, muscle-specific knockdown of dRtn4ip1 in flies resulted in impaired muscle function, which was reversed by dietary supplementation with soluble CoQ. Collectively, these results demonstrate that RTN4IP1 is a mitochondrial NAD(P)H oxidoreductase essential for supporting mitochondrial respiration activity in the muscle tissue. The development of a transgenic mouse line that expresses mitochondrial matrix-targeted APEX2 combined with proteome analysis identified RTN4IP1, which serves as an NAD(P)H oxidoreductase required for respiration and CoQ biosynthesis. | Park, Isaac; Kim, Kwang-eun; Kim, Jeesoo; Kim, Ae-Kyeong; Bae, Subin; Jung, Minkyo; Choi, Jinhyuk; Mishra, Pratyush Kumar; Kim, Taek-Min; Kwak, Chulhwan; Kang, Myeong-Gyun; Yoo, Chang-Mo; Mun, Ji Young; Liu, Kwang-Hyeon; Lee, Kyu-Sun; Kim, Jong-Seo; Suh, Jae Myoung; Rhee, Hyun-Woo | Seoul Natl Univ, Dept Chem, Seoul, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon, South Korea; Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea; Inst for Basic Sci Korea, Ctr RNA Res, Seoul, South Korea; KRIBB, Metab & Neurophysiol Res Grp, Daejeon, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Korea Brain Res Inst, Neural Circuit Res Grp, Daegu, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon, South Korea | Kim, Jong-Seo/B-6478-2009; Rhee, Hyun-Woo/AAS-4268-2021; Jung, Minkyo/HMP-0550-2023; Mun, Jiyoung/IUN-3520-2023; Mishra, Pratyush/ABC-2930-2021; Suh, Jae/B-3268-2015; Lee, Kyu-Sun/NOE-7536-2025 | 57221350729; 58390060300; 35074215000; 24173122200; 57224532908; 55701234000; 59643638200; 57208592158; 58115981500; 35940010600; 57189246012; 57211748360; 8654053900; 55768214700; 24577234300; 50961131700; 36799636000; 35734943800 | ekuse74@kribb.re.kr;jongseokim@snu.ac.kr;jmsuh@kaist.ac.kr;rheehw@snu.ac.kr; | NATURE CHEMICAL BIOLOGY | NAT CHEM BIOL | 1552-4450 | 1552-4469 | 20 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2024 | 13.7 | 3.6 | 3.73 | 2025-05-07 | 12 | 12 | SACCHAROMYCES-CEREVISIAE; MUSCLE; GENE; METHYLTRANSFERASE; METABOLISM; UBIQUINONE; MUTATIONS; PROTEINS; CELLS; IDENTIFICATION | Animals; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proteins; Oxidoreductases; Proteome; Ubiquinone; ascorbate peroxidase; binding protein; coenzyme Q3; coenzyme Q9; mitochondrial protein; oxidoreductase; proteome; reticulon 4 interacting protein 1; ubiquinone; unclassified drug; mitochondrial protein; oxidoreductase; proteome; ubiquinone; adult; animal cell; animal experiment; animal tissue; Article; biotinylation; chemical labeling; comparative study; controlled study; diet supplementation; Drosophila; embryo; enzymatic assay; enzyme engineering; enzyme synthesis; female; gene knockdown; gene knockout; human; human cell; in vitro study; interactomics; male; methylation; mitochondrial respiration; mouse; muscle function; muscle tissue; myoblast; nonhuman; protein expression; protein fingerprinting; skeletal muscle; transgenic mouse; animal; metabolism; mitochondrion | English | 2024 | 2024-02 | 10.1038/s41589-023-01452-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Self-controllable proteinic antibacterial coating with bacteria-triggered antibiotic release for prevention of periprosthetic infection | Periprosthetic infection is a devastating postimplantation complication in which a biofilm layer harboring invasive microorganisms forms around orthopedic implants, leading to severe implant failure and patient morbidity. Despite the development of several infection-triggered antibiotic release approaches, most current antibacterial coatings are susceptible to undesired antibiotic leakage or mechanical disintegration during prosthesis installation. Herein, we propose a self-controllable proteinic antibacterial coating capable of both longlasting adherence onto titanium implant substrates over the implant fixation period and instantaneous bacterial eradication. Importantly, the pH-dependent reversible metal coordination of mussel adhesive protein (MAP) enabled bacterial concentration-dependent antibiotic delivery in response to infection-induced acidification. In addition, the MAP coating exhibited superior self-healable adhesive properties and scratch resistance, which enabled to avert issues associated with mechanical damages, including peeling and cracking, often occurring in conventional implant coating systems. The gentamicin-loaded MAP coating exhibited complete inhibition of bacterial growth in vivo against Staphylococcus aureus penetrations during implantation surgery (immediate infection) and even 4 weeks after implantation (delayed infection). Thus, our antibiotic-loaded MAP hydrogel coating can open new avenues for self-defensive antibiotic prophylaxis to achieve instant and sustainable bacteriocidal activity in orthopedic prostheses. (c) 2017 Elsevier Inc. All rights reserved. | Choi, Hyun Sun; Yun, Jinyoung; Jeong, Yeonsu; Jo, Yun Kee; Cha, Hyung Joon | Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 37673, South Korea; Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Pohang Univ Sci & Technol, Sch Convergence Sci & Technol, Med Sci & Engn, Pohang 37673, South Korea | Joon, Hyung/AAO-8422-2020 | 57221766849; 59037148400; 57203275643; 56123757800; 55954303800 | ykjo@knu.ac.kr;hjcha@postech.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 305 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2024 | 12.9 | 3.6 | 2.75 | 2025-05-07 | 10 | 9 | Periprosthetic infection; Protein -based antibacterial coating; Self -controllable drug release; On -demand antibacterial therapy; Orthopedic implants | TITANIUM; NANOPARTICLES; COMPLEXATION; RIFAMPIN; DEVICES; FILM | On-demand antibacterial therapy; Orthopedic implants; Periprosthetic infection; Protein-based antibacterial coating; Self-controllable drug release | Anti-Bacterial Agents; Bacteria; Coated Materials, Biocompatible; Humans; Metals; Prostheses and Implants; Titanium; Adhesives; Bacteria; Coatings; Controlled drug delivery; Disintegration; Prosthetics; Proteins; Targeted drug delivery; gentamicin; mussel adhesive protein; antiinfective agent; biocompatible coated material; metal; titanium; Antibacterial coatings; Antibacterials; Controllable drug release; Mussel adhesive proteins; On demands; On-demand antibacterial therapy; Orthopaedic implants; Periprosthetic infection; Protein-based antibacterial coating; Self-controllable drug release; acidification; animal cell; animal experiment; animal model; antibacterial activity; antibiotic prophylaxis; Article; bacterial clearance; bacterial growth; bacterial load; bioengineering; coating (procedure); concentration response; controlled study; drug release; flow kinetics; Fourier transform infrared spectroscopy; in vivo study; infection prevention; mouse; nonhuman; pH measurement; prosthesis infection; scanning electron microscopy; Staphylococcus aureus; stoichiometry; ultraviolet visible spectroscopy; X ray photoemission spectroscopy; Young modulus; bacterium; chemistry; human; Antibiotics | English | 2024 | 2024-03 | 10.1016/j.biomaterials.2023.122457 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | An Efficient Differential Grouping Algorithm for Large-Scale Global Optimization | Cooperative co-evolution (CC) is a practical and efficient evolutionary framework for solving large-scale global optimization problems (LSGOPs). The performance of CC depends on how variables are being grouped and can be improved through guided variable decomposition for various optimization problems. However, achieving a proper variable decomposition is computationally expensive. This article proposes an effective yet efficient differential grouping (EDG) method to reduce the associated computational cost. Our method exploits the historical interrelationship information of previous variable groups to examine interactions between the remnant variable groups. This allows us to spend less computing resources without compromising the accuracy of the final grouping result. Our proposal utilizes the covariance matrix adaptation evolution strategy (CMA-ES) algorithm, in conjunction with EDG, to solve LSGOPs. Further, to reduce time complexity and improve the stability of CMA-ES, we substitute the complex matrix decomposition step with simpler matrix operations to compute the square root of the covariance matrix. Results from our experiments and analysis indicate that EDG is a competitive method to solve LSGOPs and improve the performance of CC. The proposed schemes significantly enhance the searchability of CMA-ES compared to the other large-scale variants of CMA-ES and state-of-the-art large-scale optimizers. Moreover, our EDG could be integrated with evolutionary optimizers of different flavors like differential evolution (DE). | Kumar, Abhishek; Das, Swagatam; Mallipeddi, Rammohan | TCG CREST, Inst Adv Intelligence, Kolkata 700091, India; Indian Stat Inst, Elect & Commun Sci Unit, Kolkata 700108, India; Kyungpook Natl Univ, Sch Elect Engn, Dept Artificial Intelligence, Daegu 41566, South Korea | Das, Swagatam/AAG-6753-2019; Kumar, Abhishek/ABA-5251-2021; Mallipeddi, Rammohan/AAL-5306-2020 | 57206266703; 24729258600; 25639919900 | abhishek.kumar.eee13@iitbhu.ac.in;swagatam.das@isical.ac.in;mallipeddi@knu.ac.kr; | IEEE TRANSACTIONS ON EVOLUTIONARY COMPUTATION | IEEE T EVOLUT COMPUT | 1089-778X | 1941-0026 | 28 | 1 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;COMPUTER SCIENCE, THEORY & METHODS | 2024 | 12 | 3.7 | 2.59 | 2025-05-07 | 9 | 10 | Optimization; Iron; Matrix decomposition; Covariance matrices; Computational efficiency; Search problems; Time complexity; Cooperative co-evolution (CC); covariance matrix adaptation evolution strategy (CMA-ES); efficient differential grouping (DG); large-scale optimization problems; matrix decomposition | COOPERATIVE COEVOLUTION; EVOLUTION STRATEGY; ADAPTATION; IDENTIFICATION | Cooperative co-evolution (CC); covariance matrix adaptation evolution strategy (CMA-ES); efficient differential grouping (DG); large-scale optimization problems; matrix decomposition | Covariance matrix; Evolutionary algorithms; Global optimization; Iron; Cooperative co-evolution; Covariance matrices; Covariance matrix adaptation evolution strategies; Efficient differential grouping; Large-scale optimization; Large-scale optimization problem; Matrix decomposition; Optimisations; Optimization problems; Search problem; Time complexity; Computational efficiency | English | 2024 | 2024-02 | 10.1109/tevc.2022.3230070 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Integration of an exoskeleton robotic system into a digital twin for industrial manufacturing applications | Industry 4.0 has underscored the importance of human-robot collaboration (HRC), necessitating an efficient integration of human workers and robots to achieve high -productivity manufacturing. Traditional HRC-related teaching operations rely on intuitive tools, such as a teach pendant, but are effort -intensive and require personnel with specialized skills, particularly those who use collaborative robots in manufacturing. Thus, end -effector haptic devices that offer real-time tactile feedback and easy manipulation are being explored to address these issues. However, such devices have limitations in capturing the experiential movement of users and user-friendly haptic devices that are intuitive and convenient to operate are required. Recently, the integration of HRC and digital twins for human -involved manufacturing processes is being studied. Digital twin technology is used to seamlessly connect the physical and virtual domains using virtual models for monitoring the production process and enhancing the accuracy of operational process reconfiguration. However, most teaching devices that are interfaced with digital twins in manufacturing process still demand personnel with specialized training for their operation. To address these challenges, a novel framework is proposed herein that links an exoskeleton -type robotic system with the digital twin of a collaborative robot in manufacturing processes, effectively expediting robotic task instructions. The interactions between human users and digital twins, and that between digital twins and a collaborative robot, considerably enhance our understanding of human involvement in manufacturing processes and the execution of tasks by collaborative robots. This framework comprises three subsystems: a human operator outfitted with an exoskeleton -type robot and a virtual reality (VR) device, a digital twin, and a collaborative robot. The human operator interacts with the virtual robot within the digital twin via the VR device and exoskeleton robot, whereas the collaborative robot executes the given task and transmits the measured sensor information into the digital twin. Robot tracking in the experiment and usability study of a pick -and -place process performed on the proposed framework indicates that the proposed system enhances the ease of learning and intuitiveness to human operators than the traditional teaching methods in manufacturing processes. | Park, Hoonmin; Shin, Minchul; Choi, Gyubok; Sim, Yuseop; Lee, Jiho; Yun, Huitaek; Jun, Martin Byung-Guk; Kim, Gyuman; Jeong, Younghun; Yi, Hak | Kyungpook Natl Univ, Dept Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea; Purdue Univ, Sch Mech Engn, 585 Purdue Mall, W Lafayette, IN 47907 USA; Korea Adv Inst Sci & Technol KAIST, Dept Mech Engn, 291 Daehak Ro, Daejeon 34141, Guam, South Korea | ; LEE, JIHO/JBS-1185-2023 | 57222070279; 57226714930; 58927491100; 57222070827; 57792482000; 57196328937; 58616156500; 55664733000; 56501196300; 56567311000 | hminpark96@knu.ac.kr;als7333@knu.ac.kr;yy2785@knu.ac.kr;sim46@purdue.edu;lee4503@purdue.edu;htyun@kaist.ac.kr;mbgjun@purdue.edu;gyuman.kim@knu.ac.kr;yhjeong@knu.ac.kr;yihak@knu.ac.kr; | ROBOTICS AND COMPUTER-INTEGRATED MANUFACTURING | ROBOT CIM-INT MANUF | 0736-5845 | 1879-2537 | 89 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, MANUFACTURING;ROBOTICS | 2024 | 11.4 | 3.7 | 7.34 | 2025-05-07 | 14 | 18 | Exoskeleton; Digital twin; Collaborative robot; Human-machine interface; Human-robot collaboration; Intelligent manufacturing | Collaborative robot; Digital twin; Exoskeleton; Human-machine interface; Human–robot collaboration; Intelligent manufacturing | Digital devices; Exoskeleton (Robotics); Integration; Intelligent robots; Personnel training; Virtual reality; Collaborative robots; Exoskeleton; Haptic devices; Human Machine Interface; Human operator; Human-robot collaboration; Intelligent Manufacturing; Manufacturing process; Robotic systems; Virtual reality devices; Collaborative robots | English | 2024 | 2024-10 | 10.1016/j.rcim.2024.102746 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis of crystalline g-C3N4 with rock/molten salts for efficient photocatalysis and piezocatalysis | Graphitic carbon nitride (g-C3N4) is emerging as a promising visible -light photocatalyst while the low crystallinity with sluggish charge separation/migration dynamics significantly restricts its practical applications. Currently, synthesizing highly crystalline g-C3N4 with sufficient surface activities still remains challenging. Herein, different from using alkali molten salts which is commonly reported, we propose an approach for synthesis of highly crystalline g-C3N4 with FeCl3/KCl rock/molten mixed salts. The rock salt can serve as the structure -directing template while molten salt provides the required liquid medium for re -condensation. Intriguingly, the synthesized photocatalyst showed further enhanced crystallinity and improved surface area along with high p/p* excitation compared with crystalline C3N4 prepared from conventional moltensalt methods. These catalytically advantageous features lead to its superior photocatalytic and piezocatalytic activities with a high reactivity for overall water splitting that is not commonly reported for C3N4. This work provides an effective strategy for structural optimization of organic semiconductor based materials and may inspire new ideas for the design of advanced photocatalysts. (c) 2022 Institute of Process Engineering, Chinese Academy of Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY -NC -ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Xu, Tingting; Hur, Jung; Niu, Ping; Wang, Shulan; Lee, Sangwook; Chun, Sang-Eun; Li, Li | Northeastern Univ, Coll Sci, Dept Chem, Shenyang 110819, Peoples R China; Northeastern Univ, State Key Lab Rolling & Automat, Shenyang 110819, Peoples R China; Northeastern Univ, Sch Met, Shenyang 110819, Peoples R China; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Ind Technol Adv, Daegu 41566, South Korea | Lee, Sangwook/O-9166-2015; chun, sang-eun/I-7271-2012; Xu, Tingting/AAE-8603-2022; Niu, Ping/L-8730-2013; Li, Li/ABF-1706-2020 | 57220966710; 57995637300; 36466810200; 55810395500; 57203597324; 36801080300; 56122801700 | niup@smm.neu.edu.cn;sangeun@knu.ac.kr;lilicmu@alumni.cmu.edu; | GREEN ENERGY & ENVIRONMENT | GREEN ENERGY ENVIRON | 2096-2797 | 2468-0257 | 9 | 5 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;ENGINEERING, CHEMICAL;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 14.6 | 3.7 | 3.98 | 2025-05-07 | 22 | 23 | High crystallinity; Carbon nitride; Photocatalysis; Piezocatalysis; Overall water splitting | GRAPHITIC CARBON NITRIDE; EXCITON DISSOCIATION; HYDROGEN-PRODUCTION; DOPED G-C3N4; WATER; NANOCOMPOSITES; NANOSHEETS; UREA | Carbon nitride; High crystallinity; Overall water splitting; Photocatalysis; Piezocatalysis | Carbon nitride; Crystallinity; Fused salts; Photocatalytic activity; Structural optimization; Charge-separation; Graphitic carbon nitrides; High crystallinity; Low crystallinity; Migration dynamics; Molten salt; Overall water splitting; Piezocatalyse; Visible-light photocatalysts; Water splitting; Iron compounds | English | 2024 | 2024-05 | 10.1016/j.gee.2022.10.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer's disease | Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular membrane, and regulate cellular function. However, in the blood and brain of patients with neurological disorders, including major depression, ischemic stroke, amyotrophic lateral sclerosis, multiple sclerosis, and Alzheimer's disease (AD), elevated ASM levels significantly suggest disease onset or progression. In these diseases, increased ASM is profoundly involved in neuronal death, abnormal autophagy, neuroinflammation, blood-brain barrier disruption, hippocampal neurogenesis loss, and immune cell dysfunction. Moreover, genetic and pharmacological inhibition of ASM can prevent or ameliorate various diseases. The therapeutic effects of ASM inhibition have prompted the urgent need to develop ASM inhibitors, and several ASM inhibitors have been identified. In this review, we summarize the current knowledge on the critical roles and mechanisms of ASM in brain cells and blood that are associated with different neuropathological features, especially those observed in AD. Furthermore, we elucidate the potential possibility and limitations of existing ASM-targeting drugs according to experimental studies in neurological disorder mouse models. Understanding how certain cell functions contribute to diseases is vital for creating treatments. This study explores sphingolipid metabolism. However, when this process malfunctions, it can cause various diseases. The enzyme acid sphingomyelinase is key as it produces ceramide, a lipid that, in excess, can cause cell death and contribute to diseases like Alzheimer's and major depression. The study compiles recent findings on how ASM contributes to neurological disorders, particularly Alzheimer's disease. It investigates how ASM impacts brain cells and blood, leading to symptoms like memory loss and inflammation. The review also discusses potential drugs that target ASM, offering hope for treating these disorders. The results show that high ASM levels in the brain and blood are linked to the development and progression of neurological disorders.This summary was initially drafted using artificial intelligence, then revised and fact-checked by the author. | Choi, Byung Jo; Park, Min Hee; Jin, Hee Kyung; Bae, Jae-sung | Kyungpook Natl Univ, KNU Alzheimers Dis Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll Vet Med, Dept Lab Anim Med, Daegu 41566, South Korea | Kim, Young/T-8521-2019; Bae, Jae-sung/AAM-8663-2021 | 57208899092; 55807755700; 8088145800; 35209510400 | jsbae@knu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 56 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 0.87 | 2025-05-07 | 8 | 7 | TH17 CELLS; HIPPOCAMPAL NEUROGENESIS; FUNCTIONAL INHIBITORS; INDUCED CERAMIDE; AUTOPHAGY; SPHINGOLIPIDS; METABOLISM; SYSTEM; DEATH; IDENTIFICATION | Alzheimer Disease; Animals; Brain; Humans; Mice; Multiple Sclerosis; Nervous System Diseases; Sphingomyelin Phosphodiesterase; 23A12C3; ad 2765; amitriptyline; arc 39; ent 12; fluoxetine; imipramine; kari 201; monoclonal antibody; sphingomyelin phosphodiesterase; sphingomyelin phosphodiesterase inhibitor; unclassified drug; sphingomyelin phosphodiesterase; Alzheimer disease; astrocyte; blood brain barrier; drug distribution; drug targeting; endothelium cell; enzyme inhibition; human; immunotherapy; inflammation; ischemic stroke; major depression; microglia; nerve cell necrosis; neurologic disease; neuropathology; nonhuman; oxidative stress; protein blood level; Review; traumatic brain injury; Alzheimer disease; animal; brain; genetics; mouse; multiple sclerosis; neurologic disease | English | 2024 | 2024-02 | 10.1038/s12276-024-01176-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling | M2-like tumor-associated macrophages (TAMs) are risk factors for cancer progression and metastasis. However, the mechanisms underlying their polarization are still not fully understood. Although cathepsin D (Cat D) has been reported as a procarcinogenic factor, little is known about the functional role of Cat D in the tumor microenvironment (TME). This study aimed to explore the effect and molecular mechanisms of Cat D in the TME. Cat D knockout (KO) altered the cytokine secretion pattern and induced TAM reprogramming from the M2 to M1 subtype, thereby preventing epithelial-mesenchymal transition and tumor metastasis. Mechanistically, we identified transforming growth factor beta-induced protein (TGFBI) as a Cat D target protein that is specifically associated with TAM polarization. Elevated TGFBI expression in Cat D KO cancer cells resulted in a decline in M2-like TAM polarization. Our RNA-sequencing results indicated that the cancer cell-secreted chemokine CCL20 is a major secretory chemokine for Cat D-TGFBI-mediated TAM polarization. In contrast, Cat D overexpression accelerated TAM polarization into M2-like cells by suppressing TGFBI expression. In addition, the double Cat D and TGFBI KO rescued the inhibitory effects of Cat D KO on tumor metastasis by controlling TAM and T-cell activation. These findings indicated that Cat D contributes to cancer metastasis through TGFBI-mediated TAM reprogramming. Cat D deletion inhibits M2-like TAM polarization through TGFBI-mediated CCL20 expression, reprogramming the immunosuppressive TME. Our results open a potential new avenue for therapy focused on eliminating tumor metastasis. | Lee, Seul Gi; Woo, Seon Min; Seo, Seung Un; Lee, Chan-Hyeong; Baek, Moon-Chang; Jang, Se Hwan; Park, Zee Yong; Yook, Simmyung; Nam, Ju-Ock; Kwon, Taeg Kyu | Keimyung Univ, Sch Med, Dept Immunol, Daegu, South Korea; Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA USA; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Exosome Convergence Res Ctr ECRC,CMRI, Daegu, South Korea; Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju, South Korea; Sungkyunkwan Univ, Dept Biopharmaceut Convergence, Suwon, South Korea; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu, South Korea; Keimyung Univ, Ctr Forens Pharmaceut Sci, Daegu, South Korea | ; Park, Jun/H-7127-2019 | 56995397800; 57199873466; 57195411399; 57189904697; 7006013097; 56579566300; 6603940093; 49962665100; 7201496105; 7202206057 | kwontk@dsmc.or.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 56 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 3.92 | 2025-05-07 | 10 | 11 | EXPRESSION; CANCER; INHIBITION; PROTEIN; CELLS | Biological Transport; Cathepsin D; Chemokine CCL20; Signal Transduction; Tumor-Associated Macrophages; cathepsin D; macrophage inflammatory protein 3alpha; transforming growth factor beta; cathepsin D; macrophage inflammatory protein 3alpha; animal cell; animal experiment; animal tissue; Article; cancer cell; cancer therapy; Cat D gene; controlled study; cytokine release; disease association; enzyme activity; enzyme analysis; epithelial mesenchymal transition; female; gene overexpression; human; human cell; lymphocyte activation; M1 macrophage; M2 macrophage; metastasis; mouse; nonhuman; nuclear reprogramming; polarization; protein expression; protein targeting; RNA sequencing; signal transduction; T lymphocyte; tumor microenvironment; tumor-associated macrophage; genetics; signal transduction; transport at the cellular level | English | 2024 | 2024-02 | 10.1038/s12276-024-01163-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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