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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Effects of serum aspartate aminotransferase activity on levels of serum Ca²⁺, Ca²⁺ channel genes, apoptotic factors, and meat quality characteristics of chicken pectoralis major muscle | This study investigated the association between serum aspartate aminotransferase activity and apoptotic potentials assessed by the levels of serum parameters, including Ca2+ and serotonin, Ca2+ channel genes, and caspase genes, at the early postmortem. Additionally, the effect of serum aspartate aminotransferase activity on meat and sensory quality characteristics of chicken pectoralis major muscle was investigated to determine the cause of meat quality deterioration. Among the groups categorized by serum aspartate aminotransferase activity, the high group showed a higher serotonin level and a lower Ca2+ level than the low and medium groups (P < 0.05). The low group had higher apoptotic potentials as exhibited higher levels of ryanodine receptor, sarco/endoplasmic reticulum Ca2+-ATPase, and caspases than the high group (P < 0.05). The low and medium groups showed lower pH(24 h) and paler surface color than the high group (P < 0.05), indicating pale, soft, and exudative-like meat. Sensory juiciness and overall acceptability were higher in the high group than in the low group (P < 0.05). Overall, serum aspartate aminotransferase activity may be a useful indicator for explaining the meat quality variation, as this molecule can prevent deterioration of chicken meat quality. | Lee, Boin; Kim, Jae Yeong; Choi, Young Min | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea | 57218130871; 57226306561; 57226673843 | ymchoi1@knu.ac.kr; | POULTRY SCIENCE | POULTRY SCI | 0032-5791 | 1525-3171 | 101 | 12 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | 2022 | 4.4 | 5.6 | 0.95 | 2025-06-25 | 5 | 5 | aspartate aminotransferase; apoptotic potentials; calcium channels; caspases; chicken meat quality | CALCIUM HOMEOSTASIS; CELL-DEATH; PALE; SOFT; MITOCHONDRIAL; EXPRESSION | apoptotic potentials; aspartate aminotransferase; calcium channels; caspases; chicken meat quality | Animals; Aspartate Aminotransferases; Chickens; Meat; Pectoralis Muscles; Serotonin; aspartate aminotransferase; serotonin; animal; chicken; genetics; meat; pectoral muscle; physiology | English | 2022 | 2022-12 | 10.1016/j.psj.2022.102214 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Energy Efficiency Maximization Precoding for Quantized Massive MIMO Systems | The use of low-resolution digital-to-analog and analog-to-digital converters (DACs and ADCs) significantly benefits energy efficiency (EE) at the cost of high quantization noise for massive multiple-input multiple-output (MIMO) systems. This paper considers a precoding optimization problem for maximizing EE in quantized downlink massive MIMO systems. To this end, we jointly optimize an active antenna set, precoding vectors, and allocated power; yet acquiring such joint optimal solution is challenging. To resolve this challenge, we decompose the problem into precoding direction and power optimization problems. For precoding direction, we characterize the first-order optimality condition, which entails the effects of quantization distortion and antenna selection. We cast the derived condition as a functional eigenvalue problem, wherein finding the principal eigenvector attains the best local optimal point. To this end, we propose generalized power iteration based algorithm. To optimize precoding power for given precoding direction, we adopt a gradient descent algorithm for the EE maximization. Alternating these two methods, our algorithm identifies a joint solution of the active antenna set, the precoding direction, and allocated power. In simulations, the proposed methods provide considerable performance gains. Our results suggest that a few-bit DACs are sufficient for achieving high EE in massive MIMO systems. | Choi, Jinseok; Park, Jeonghun; Lee, Namyoon | Ulsan Natl Inst Sci & Technol UNIST, Dept Elect Engn, Ulsan 44919, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Korea Univ, Sch Elect Engn, Seoul 02841, South Korea | ; Lee, Namyoon/ADH-9232-2022; Choi, Jinseok/AAL-6383-2020 | 57190581671; 57853652900; 35148128800 | jinseokchoi@unist.ac.kr;jeonghun.park@knu.ac.kr;namyoon@korea.ac.kr; | IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS | IEEE T WIREL COMMUN | 1536-1276 | 1558-2248 | 21 | 9 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 10.4 | 5.6 | 1.83 | 2025-06-25 | 14 | 20 | Precoding; Massive MIMO; Quantization (signal); Downlink; Antennas; Optimization; Transmitting antennas; Low-resolution analog-to-digital converter (ADC); digital-to-analog converter (DAC); energy efficiency (EE); precoding; antenna selection; massive multiple-input multiple-output (MIMO); eigenvalue problem | ONE-BIT; SELECTION; WIRELESS; DESIGN | antenna selection; eigenvalue problem; energy efficiency (EE); Low-resolution analog-to-digital converter (ADC)/digital-to-analog converter (DAC); massive multiple-input multiple-output (MIMO); precoding | Digital to analog conversion; Eigenvalues and eigenfunctions; Energy efficiency; Gradient methods; MIMO systems; Optimization; Quantization (signal); Downlink; Massive multiple-input multiple-output; Multiple inputs; Multiple outputs; Multiple-Input Multiple- Output systems; Optimisations; Power; Precoding; Quantization (signal); Transmitting antenna; Antennas | English | 2022 | 2022-09 | 10.1109/twc.2022.3152491 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Five-Level Current Source Inverter With Inductor Cell Using Switching-Cell Structure | This article proposes a single-phase five-level current source inverter with an inductor cell based on the switching-cell (SC) structure. Compared to the conventional inverter, the proposed structure has no open-circuit problem; thus, its reliability is greatly enhanced. The overlap-time inserted in the driving signals can also be minimized to improve the output waveform quality. The proposed inverter's operation is analyzed herein, and the design guideline of SC capacitors is discussed. In addition, the SC extension for the n-level topology is provided. A 1-kW prototype is built and tested to validate the effectiveness of the proposed structure. | Tien-The Nguyen; Cha, Honnyong | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea | Nguyen, Tien/ABX-3214-2022 | 59454647000; 24450248400 | thetien93@knu.ac.kr;chahonny@knu.ac.kr; | IEEE TRANSACTIONS ON INDUSTRIAL ELECTRONICS | IEEE T IND ELECTRON | 0278-0046 | 1557-9948 | 69 | 7 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;INSTRUMENTS & INSTRUMENTATION | 2022 | 7.7 | 5.6 | 1.14 | 2025-06-25 | 10 | 15 | Inductors; Inverters; Switches; Capacitors; Switching circuits; Topology; Periodic structures; Current source inverter (CSI); five-level; high reliability; open-circuit; switching-cell (SC) | VOLTAGE-SOURCE; EFFICIENCY | Current source inverter (CSI); five-level; high reliability; open-circuit; switching-cell (SC) | Cells; Cytology; Switching; Cell-based; Conventional inverters; Current source inverter; Driving signal; Open circuits; Output waveform; Single phase; Switching cells; Electric inverters | English | 2022 | 2022-07 | 10.1109/tie.2021.3101008 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Heterologous ChAdOx1 and Bnt162b2 vaccination induces strong neutralizing antibody responses against SARS-CoV-2 including delta variant with tolerable reactogenicity | Objectives: We assessed humoral responses and reactogenicity following the heterologous vaccination compared to the homologous vaccination groups. Methods: We enrolled healthcare workers (HCWs) who were either vaccinated with ChAdOx1 followed by BNT162b2 (heterologous group) or 2 doses of ChAdOx1 (ChAdOx1 group) or BNT162b2 (BNT162b2 group). Immunogenicity was assessed by measuring antibody titers against receptor-binding domain (RBD) of SARS-CoV-2 spike protein in all participants and neutralizing antibody titer in 100 participants per group. Reactogenicity was evaluated by a questionnaire-based survey. Results: We enrolled 499 HCWs (ChAdOx1, n = 199; BNT162b2, n = 200; heterologous ChAdOx1/BNT162b2, n = 100). The geometric mean titer of anti-receptor-binding domain antibody at 14 days after the booster dose was significantly higher in the heterologous group (11 780.55 binding antibody unit (BAU)/mL [95% CI, 10 891.52-12 742.14]) than in the ChAdOx1 (1561.51 [95% CI, 1415.03-1723.15]) or BNT162b2 (2895.90 [95% CI, 2664.01-3147.98]) groups (both p 0.05) but higher than that of the ChAdOx1 group (391.77 [95% CI, 326.16-470.59]; p < 0.001). Compared with those against wild-type SARS-CoV-2, the geometric mean neutralizing antibody titers against the Delta variant at 14 days after the boosting were reduced by 3.0-fold in the heterologous group (geometric mean ND50, 872.01 [95% CI, 685.33-1109.54]), 4.0-fold in the BNT162b2 group (337.93 [95% CI, 262.78-434.57]), and 3.2-fold in the ChAdOx1 group (206.61 [95% CI, 144.05-296.34]). The local or systemic reactogenicity after the booster dose in the heterologous group was higher than that of the ChAdOx1 group but comparable to that of the BNT162b2 group. Discussion: Heterologous ChAdOx1 followed by BNT162b2 vaccination with a 12-week interval induced a robust humoral immune response against SARS-CoV-2, including the Delta variant, that was comparable to the homologous BNT162b2 vaccination and stronger than the homologous ChAdOx1 vaccination, with a tolerable reactogenicity profile. (C) 2022 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved. | Bae, Seongman; Ko, Jae-Hoon; Choi, Ju-Yeon; Park, Woo-Jung; Lim, So Yun; Ahn, Jin Young; Song, Kyoung-Ho; Lee, Kyoung Hwa; Song, Young Goo; Kim, Yong Chan; Park, Yoon Soo; Choi, Won Suk; Jeong, Hye Won; Kim, Shin-Woo; Kwon, Ki Tae; Kang, Eun-Suk; Kim, Ah-Ra; Jang, Sundong; Kim, Byoungguk; Kim, Sung Soon; Jang, Hee-Chang; Choi, Jun Yong; Kim, Sung-Han; Peck, Kyong Ran | Univ Ulsan, Asan Med Ctr, Dept Infect Dis, Coll Med, 88,Olymp Ro 43 Gil, Seoul 05505, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Div Infect Dis,Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Korea Dis Control & Prevent Agcy, Natl Inst Hlth, Natl Inst Infect Dis, Cheongju, Chungcheongbuk, South Korea; Yonsei Univ, Severance Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Bundang Hosp, Seongnam, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Seoul, South Korea; Yonsei Univ, Yongin Severance Hosp, Dept Internal Med, Div Infect Dis,Coll Med, Yongin, South Korea; Korea Univ, Coll Med, Dept Internal Med, Div Infect Dis,Ansan Hosp, Ansan, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Dept Internal Med, Coll Med, Cheongju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Internal Med,Div Infect Dis, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med & Genet, Sch Med, Seoul, South Korea | ; Peck, Kyong Ran/AGV-5205-2022; Lee, Kyoung-Hwa/AAJ-5213-2021; Park, Yoon/C-6472-2015; Choi, Jah/AAA-4835-2022; Hwang, Soyoon/HHM-5762-2022; Choi, Won/V-2730-2017; Jeong, Hye/AET-1982-2022; Choi, Won Suk/V-2730-2017 | 57189690904; 55804188300; 57203732512; 57203475824; 57194068306; 57225850337; 23398486700; 56955948100; 55675198500; 57817997500; 7405373036; 56718971800; 13103042700; 8710731500; 9733850500; 20234715300; 57222144793; 57196466758; 57792610600; 57218856689; 7202135138; 57791298700; 55133790400; 55664295200 | seran@yuhs.ac;kimsunghanmd@hotmail.com;krpeck@skku.edu; | CLINICAL MICROBIOLOGY AND INFECTION | CLIN MICROBIOL INFEC | 1198-743X | 1469-0691 | 28 | 10 | SCIE | INFECTIOUS DISEASES;MICROBIOLOGY | 2022 | 14.2 | 5.6 | 2.38 | 2025-06-25 | 22 | 22 | BNT162b2; ChAdOx1; COVID-19; Heterologous vaccination; SARS-CoV-2 | IMMUNOGENICITY | BNT162b2; ChAdOx1; COVID-19; Heterologous vaccination; SARS-CoV-2 | Antibodies, Neutralizing; Antibodies, Viral; BNT162 Vaccine; COVID-19; Humans; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Vaccination; coronavirus spike glycoprotein; neutralizing antibody; tozinameran; vaxzevria; coronavirus spike glycoprotein; neutralizing antibody; spike protein, SARS-CoV-2; virus antibody; adult; antibody blood level; antibody response; antibody titer; Article; blood sampling; cohort analysis; controlled study; coronavirus disease 2019; demographics; drug tolerability; fatigue; female; headache; health care personnel; human; humoral immunity; major clinical study; male; observational study; pain; plaque reduction neutralization test; prospective study; questionnaire; receptor binding; SARS-CoV-2 Delta; treatment response; vaccination; vaccine immunogenicity; variant of concern; wild type; genetics; prevention and control; vaccination | English | 2022 | 2022-10 | 10.1016/j.cmi.2022.04.019 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Precoding Design for Multi-User MISO Systems With Delay-Constrained and -Tolerant Users | In both academia and industry, multi-user multiple-input single-output (MU-MISO) techniques have shown enormous gains in spectral efficiency by exploiting spatial degrees of freedom. So far, an underlying assumption in most of the existing MU-MISO design has been that all the users use infinite blocklength, so that they can achieve the Shannon capacity. This setup, however, is not suitable considering delay-constrained users whose blocklength tends to be finite. In this paper, we consider a heterogeneous setting in MU-MISO systems where delay-constrained users and delay-tolerant users coexist, called a DCTU-MISO network. To maximize the sum spectral efficiency in this system, we present the spectral efficiency for delay-tolerant users and provide a lower bound of the spectral efficiency for delay-constrained users. We consider an optimization problem that maximizes the sum spectral efficiency of delay-tolerant users while satisfying the latency constraint of delay-constrained users, and propose a generalized power iteration (GPI) precoding algorithm that finds a principal precoding vector. Furthermore, we extend a DCTU-MISO network to the multiple time slots scenario and propose a recursive GPI precoding algorithm. In simulation results, we validate proposed methods outperform baseline schemes and present the effect of network parameters on the average sum spectral efficiency. | Kim, Minsu; Park, Jeonghun; Lee, Jemin | Daegu Gyeongbuk Inst Sci & Technol, Dept Informat & Commun Engn, Daegu 42988, South Korea; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Sungkyunkwan Univ, Dept Elect & Comp Engn, Suwon 16419, South Korea | Lee, Jemin/D-7275-2015 | 59628538500; 57853652900; 37960927700 | ads5577@dgist.ac.kr;jeonghun.park@knu.ac.kr;jemin.lee@skku.edu; | IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS | IEEE T WIREL COMMUN | 1536-1276 | 1558-2248 | 21 | 7 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 10.4 | 5.6 | 5.07 | 2025-06-25 | 10 | 11 | Precoding; Optimization; Downlink; Ultra reliable low latency communication; MIMO communication; Resource management; Array signal processing; Multi-user multiple-input multiple-output; ultra-reliable low-latency communication; finite blocklength; spectral efficiency; incremental redundancy hybrid automatic repeat request | SHORT BLOCKLENGTH REGIME; RESOURCE-ALLOCATION; POWER ALLOCATION; MIMO; DOWNLINK; PERFORMANCE; THROUGHPUT; SELECTION | finite blocklength; incremental redundancy hybrid automatic repeat request; Multi-user multiple-input multiple-output; spectral efficiency; ultra-reliable low-latency communication | Array processing; Codes (symbols); Constrained optimization; Degrees of freedom (mechanics); Error correction; Iterative methods; MIMO systems; Array signal processing; Downlink; Finite blocklength; Hybrid automatic repeat request; Hybrid-automatic repeat request; Incremental redundancy; Incremental redundancy hybrid automatic repeat request; Low-latency communication; MIMO communication; Multi-user multiple-input multiple-output; Multiple inputs; Multiple outputs; Multiusers; Optimisations; Precoding; Resource management; Spectral efficiencies; Ultra reliable low latency communication; Ultra-reliable low-latency communication; Spectrum efficiency | English | 2022 | 2022-07 | 10.1109/twc.2021.3136872 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Research Note: PSE condition is associated with increased apoptotic potential in broiler pectoralis major muscle | This study compared the meat quality and sensory quality characteristics of broiler pectoralis major (PM) muscle between meat quality classes, including reddish, firm, and non-exudative (RFN) and pale, soft, and exudative (PSE) conditions. Additionally, we also investigated the associations between the meat quality classes and expression levels of cytochrome c, initiator (caspase 9), and effector caspases (caspase 3 and 7) at the early postmortem period. A total of 135 PM muscles from broilers were used, and meat quality classes were determined according to the pH(24) h and lightness values and classified into the RFN (N = 81) and PSE (N = 54) conditions. The PSE breasts showed lower muscle pH15 min and pH24 h values compared to the RFN breasts (P 0.05). The PSE group exhibited higher extent of water loss, including drip loss and cooking loss, com-pared to the RFN group (P 0.05). At 15 min postmortem, all apoptosis-related molecules, including cytochrome c, caspase 9, caspase 3, and caspase 7, were present at higher levels in the PSE group than in the RFN group (P < 0.05). These results indicated that higher apoptotic potentials were associated with the development of PSE chicken breasts. Therefore, the variation of meat quality in chicken breast can be explained as being affected by the expression levels of apoptosis-related factors at the early postmortem period. | Lee, Boin; Choi, Young Min | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, Sangju Si 37224, South Korea | 57218130871; 57226673843 | ymchoi1@knu.ac.kr; | POULTRY SCIENCE | POULTRY SCI | 0032-5791 | 1525-3171 | 101 | 11 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE | 2022 | 4.4 | 5.6 | 0.57 | 2025-06-25 | 3 | 3 | cytochrome c; caspases; apoptotic potential; meat quality; chicken breast | MEAT QUALITY; TURKEY MEAT; PALE; SOFT | apoptotic potential; caspases; chicken breast; cytochrome c; meat quality | Animals; Caspase 3; Caspase 9; Chickens; Cytochromes c; Meat; Pectoralis Muscles; caspase 3; caspase 9; cytochrome c; animal; chicken; meat; pectoral muscle; physiology | English | 2022 | 2022-11 | 10.1016/j.psj.2022.102107 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Sensor-Aided Learning for Wi-Fi Positioning With Beacon Channel State Information | Because each indoor site has its own radio propagation characteristics, a site survey process is essential to optimize a Wi-Fi ranging strategy for range-based positioning solutions. This study examines an unsupervised learning technique that autonomously learns an optimal ranging strategy for each site using Wi-Fi and sensor data accumulated while users access a positioning application. Using the collected sensor data, the device trajectory is regenerated, and a Wi-Fi ranging module is optimized to generate the shape of the estimated trajectory using Wi-Fi, similar to that obtained from sensors. In this process, the ranging module learns the way to identify the channel conditions from each Wi-Fi access point (AP) and produces ranging results accordingly. Furthermore, we collect the channel state information (CSI) from beacon frames to investigate the benefit of using CSI in addition to received signal strength measurements. With the CSI, the ranging module can identify diverse channel conditions from each AP and more accurately generate the reliability of each distance estimate to achieve accurate positioning results. The effectiveness of the proposed learning technique is verified using a real-time positioning application implemented on a PC platform. | Choi, Jeongsik | Intel Corp, Intel Labs, Santa Clara, CA 95054 USA; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Choi, Jeongsik/ABA-6906-2020 | 58534394200 | jeongsik.choi@knu.ac.kr; | IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS | IEEE T WIREL COMMUN | 1536-1276 | 1558-2248 | 21 | 7 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 10.4 | 5.6 | 1.93 | 2025-06-25 | 16 | 20 | Distance measurement; Wireless fidelity; Trajectory; Feature extraction; Wireless communication; Performance evaluation; Mobile handsets; Indoor positioning; channel state information; neural networks; unsupervised learning; sensor fusion | CONVOLUTIONAL NEURAL-NETWORKS; OF-SIGHT IDENTIFICATION; INDOOR LOCALIZATION; TRACKING | channel state information; Indoor positioning; neural networks; sensor fusion; unsupervised learning | Backpropagation; Channel state information; Indoor positioning systems; Neural networks; Radio waves; Unsupervised learning; Wi-Fi; Wireless local area networks (WLAN); Channel-state information; Features extraction; Indoor positioning; Learning techniques; Mobile handsets; Neural-networks; Performances evaluation; Sensor fusion; Wireless communications; Wireless fidelities; Trajectories | English | 2022 | 2022-07 | 10.1109/twc.2021.3138850 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Sparse Joint Transmission for Cloud Radio Access Networks With Limited Fronthaul Capacity | A cloud radio access network (C-RAN) is a promising cellular network, wherein densely deployed multi-antenna remote-radio-heads (RRHs) jointly serve many users using the same time-frequency resource. By extremely high signaling overheads for both channel state information (CSI) acquisition and data sharing at a baseband unit (BBU), finding a joint transmission strategy with a significantly reduced signaling overhead is indispensable to achieve the cooperation gain in practical C-RANs. In this paper, we present a novel sparse joint transmission (sparse-JT) method for C-RANs, where the number of transmit antennas per unit area is much larger than the active downlink user density. Considering the effects of noisy-and-incomplete CSI and the quantization errors in data sharing by a finite-rate fronthaul capacity, the key innovation of sparse-JT is to find a joint solution for cooperative RRH clusters, beamforming vectors, and power allocation to maximize a lower bound of the sum-spectral efficiency under the sparsity constraint of active RRHs. To find such a solution, we present a computationally efficient algorithm that guarantees to find a local-optimal solution for a relaxed sum-spectral efficiency maximization problem. By system-level simulations, we exhibit that sparse-JT provides significant gains in ergodic spectral efficiencies compared to existing joint transmissions. | Han, Deokhwan; Park, Jeonghun; Park, Seok-Hwan; Lee, Namyoon | POSTECH, Dept Elect Engn, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Coll It Engn, Sch Elect Engn, Daegu 41566, South Korea; Jeonbuk Natl Univ, Coll Engn, Div Elect Engn, Jeonju 54896, South Korea; Korea Univ, Dept Elect Engn, Seoul 13613, South Korea | ; Lee, Namyoon/ADH-9232-2022 | 57210284486; 57853652900; 27867920900; 35148128800 | dhhan@postech.ac.kr;jeonehun.park@knu.ac.kr;seokhwan@jbnu.ac.kr;namyoon@korea.ac.kr; | IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS | IEEE T WIREL COMMUN | 1536-1276 | 1558-2248 | 21 | 5 | SCIE | ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2022 | 10.4 | 5.6 | 0.87 | 2025-06-25 | 4 | 9 | Downlink; Precoding; Optimization; Array signal processing; Noise measurement; Channel estimation; Quantization (signal); Cloud radio access network (C-RAN); cooperative transmission | CHANNEL ESTIMATION; POWER ALLOCATION; MIMO; DOWNLINK; DESIGN; COMPRESSION; PERFECT; CSIT | Cloud radio access network (C-RAN); cooperative transmission | Antennas; Array processing; Beamforming; Channel estimation; Channel state information; Energy efficiency; MIMO systems; Radio transmission; Channel-state information; Data Sharing; Downlink; Joint transmissions; Noise measurements; Optimisations; Precoding; Quantization (signal); Radio access networks; Remote radio heads; Quantization (signal) | English | 2022 | 2022-05 | 10.1109/twc.2021.3121398 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Molten-Salt Processed Potassium Sodium Niobate Single-Crystal Microcuboids with Dislocation-Induced Nanodomain Structures and Relaxor Ferroelectric Behavior | We herein report a facile molten-salt synthetic strategy to prepare transparent and uniform Li, Ba-doped (K,Na)NbO3 (KNN) single-crystal microcuboids (similar to 80 mu m). By controlling the degree of supersaturation, different growth modes were found and the single crystal microcuboids were synthesized via island-like oriented attachment of KNN particles onto the growing surface. The distinct relaxor ferroelectric (RFE) properties were achieved in the single-crystal microcuboids, which were different from the normal ferroelectric (FE) properties found in their KNN ceramic counterparts prepared through a solid-state reaction using the same initial precursors. The RFE properties were realized by dislocation-induced nanodomain formation during oriented attachment growth of single-crystal microcuboids, which is different from the current strategies to derive the nanodomains by the local compositional inhomogeneity or the application of an electric field. The dislocations served as nucleation sites for ferroelectric domain walls and block the growth of domains. The KNN single-crystal microcuboids exhibited a higher effective piezoelectric coefficient (similar to 459 pm/V) compared to that of the bulk KNN ceramic counterpart (similar to 90 pm/V) and showed the broad diffuse maxima in the temperature dependence dielectric permittivity. The high maximum polarization (69.6 mu C/cm2) at a relatively low electric field (30 kV/cm) was beneficial for energy storage applications. Furthermore, the KNN-based transparent, flexible pressure sensor directly monitored the mechanical motion of human activity without any external electric power. This study provides insights and synthetic strategies of single-crystal RFE microcuboids for other different perovskites, in which nanodomain structures are primarily imposed by their chemical composition. | Park, Seonhwa; Choi, Hyunsu; Hwang, Geon-Tae; Peddigari, Mahesh; Ahn, Cheol-Woo; Hahn, Byung-Dong; Yoon, Woon-Ha; Lee, Jung Woo; Park, Kwi-Il; Jang, Jongmoon; Choi, Jong-Jin; Min, Yuho | Korea Inst Mat Sci KIMS, Dept Funct Ceram, Ceram Mat Div, Chang Won 51508, Gyeongnam, South Korea; Pukyong Natl Univ, Dept Mat Sci & Engn, Pusan 48513, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Choi, Jong-Jin/D-3396-2009; Han, Guifang/AAS-5700-2020; Park, Kwiil/LKN-9445-2024; Min, Yuho/AAA-1287-2020 | 58437403700; 57853701000; 36704574900; 56316365700; 7201986655; 10639824200; 15833577200; 57208309536; 35280874200; 55851287300; 57199099597; 36782804100 | yuhomin@knu.ac.kr;finaljin@kims.re.kr;jongmoon@kims.re.kr; | ACS NANO | ACS NANO | 1936-0851 | 1936-086X | 16 | 9 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 17.1 | 5.7 | 0.85 | 2025-06-25 | 10 | 10 | single-crystal microcuboid; potassium sodium niobite; molten-salt synthesis; relator ferroelectric; nanodomain; dislocation; transparent electronics | ENERGY DENSITY; GROWTH; POLARIZATION; MORPHOLOGY; FILM | dislocation; molten-salt synthesis; nanodomain; potassium sodium niobite; relaxor ferroelectric; single-crystal microcuboid; transparent electronics | Domain walls; Ferroelectric materials; Ferroelectricity; Fused salts; Lithium compounds; Niobium compounds; Permittivity; Perovskite; Piezoelectricity; Potassium; Sodium; Sodium compounds; Solid state reactions; Temperature distribution; Dislocation; Ferroelectric property; Molten salt; Molten salts synthesis; Nanodomain; Nanodomain structures; Potassium sodium niobite; Relaxor ferroelectric; Single-crystal microcuboid; Transparent electronics; Single crystals | English | 2022 | 2022-09-27 | 10.1021/acsnano.2c06919 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | One-Dimensional Porous Li-Confinable Hosts for High-Rate and Stable Li-Metal Batteries | Li-confinable core-shell hosts have been extensively studied because they mitigate Li dendrite growth and volume change by reducing the effective current density and storing Li inside the core space during consecutive cycling. However, despite these fascinating features, these hosts suffer from unwanted Li growth on their surface (i.e., top plating) due to the carbon shell hindering Li-ion movement especially at higher current densities and capacities, resulting in poor electrochemical performance. In this study, we propose a one-dimensional porous Li-confinable host with lithiophilic Au (Au@PHCF), which is synthesized by a scalable dual-nozzle electrospinning. Because of the well-interconnected conductive networks forming three-dimensional structure, porous shell design enabling facile Li-ion transport, and hollow core space with lithiophilic Au storing metallic Li, the Au@PHCF can suppress the Li top plating and improve the Li stripping/plating efficiency compared to their counterparts even at 5 mA cm-2, eventually achieving stable cycling performances of the LiFePO4full cell and Au@PHCF-Li symmetric cell for over 1000 and 2000 cycles, respectively. Finite element analysis reveals that the structural merit and lithiophilicity of Au enable fast reversible Li operation at the designated core space of the Au@PHCF, implying that the structural design of the Li-confinable host is crucial for the stable operation of promising Li-metal batteries at a practical test level. © 2022 American Chemical Society. All rights reserved. | Kang, Dong Woo; Park, Seong Soo; Choi, Hong Jun; Park, Jun-Ho; Lee, Ji Hoon; Lee, Sang-Min; Choi, Jeong-Hee; Moon, Janghyuk; Kim, Byung Gon | Next Generation Battery Research Center, Korea Electrotechnology Research Institute (KERI), 12 Jeongiui-gil, Seongsan-gu Gyeongsangnam-do, Changwon-si, 51543, South Korea; School of Energy Systems Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjakgu, Seoul, 6974, South Korea; Next Generation Battery Research Center, Korea Electrotechnology Research Institute (KERI), 12 Jeongiui-gil, Seongsan-gu Gyeongsangnam-do, Changwon-si, 51543, South Korea; Next Generation Battery Research Center, Korea Electrotechnology Research Institute (KERI), 12 Jeongiui-gil, Seongsan-gu Gyeongsangnam-do, Changwon-si, 51543, South Korea; School of Materials Science and Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea; Graduate Institute of Ferrous and Energy Materials Technology, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-gu Gyeongbuk, Pohang, 37673, South Korea; Next Generation Battery Research Center, Korea Electrotechnology Research Institute (KERI), 12 Jeongiui-gil, Seongsan-gu Gyeongsangnam-do, Changwon-si, 51543, South Korea, Electro-functional Materials Engineering, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, South Korea; School of Energy Systems Engineering, Chung-Ang University, 84 Heukseok-ro, Dongjakgu, Seoul, 6974, South Korea; Next Generation Battery Research Center, Korea Electrotechnology Research Institute (KERI), 12 Jeongiui-gil, Seongsan-gu Gyeongsangnam-do, Changwon-si, 51543, South Korea, Electro-functional Materials Engineering, University of Science and Technology (UST), 217 Gajeong-ro, Yuseong-gu, Daejeon, 34113, South Korea | 57390996300; 59304816800; 55972741600; 55595703000; 55689885200; 57254918800; 57199098838; 55308990300; 55616189100 | jhmoon84@cau.ac.kr;byunggonkim@keri.re.kr; | ACS Nano | ACS NANO | 1936-0851 | 1936-086X | 16 | 8 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2022 | 17.1 | 5.7 | 2.62 | 2025-06-25 | 31 | core-shell Li host; electrospinning; finite element analysis; Li-metal battery; porous shell design | Finite element method; Gold; Iron compounds; Lithium compounds; Lithium-ion batteries; Phosphorus compounds; Shells (structures); Structural design; Core shell; Core-shell li host; Finite element analyse; High rate; Li metal; Li-metal battery; One-dimensional; Porous shell design; Porous shells; Shell design; Electrospinning | English | Final | 2022 | 10.1021/acsnano.2c01309 | 바로가기 | 바로가기 | 바로가기 | |||||||
| ○ | ○ | Article | The effects of customer consumption goals on artificial intelligence driven recommendation agents: evidence from Stitch Fix | The purpose of this study is to investigate the influence of consumer goals on artificial intelligence (AI) driven interactive recommendation agents (IRAs) and examine the effects of consumers' consumption goals on their attitude toward IRAs and their perception of IRA value in the context of Stitch Fix. In this study, we also investigate the attitude toward IRAs and IRA value that influence the intention to use IRAs. AI powered recommendation agents have achieved noticeable outcomes in the contactless era by boosting revenues and customer value. On the Stitch Fix platform, an online personal styling service platform, AI-driven IRAs provide personalized recommendations to customers encompassing fashion styling and product design. In this study that considers the Stitch Fix context, a successful case of AI-driven IRAs, a survey was used to investigate key questions about the relationships among goals, IRA value, attitude, and intention to use AI-driven IRAs on the Stitch Fix platform. The participants were 321 AI-driven IRA users from South Korea recruited by a professional survey company. In conclusion, the study clarifies the relationship between personal hedonic goals and attitude and the value of IRAs, and the effects of these goals that ultimately influence the intention to use IRAs. The findings offer practical implications for IRAs that can be used to help consumers search and choose products. IRAs can be particularly helpful for engaging consumers with hedonic goals, stimulation, and comfort, especially consumers who seek comfort, as they are more likely to show a positive attitude and value IRAs, which could encourage behavior adherence. Advertising practitioners should target consumers who seek comfort to enhance personalized recommendation strategies via AI-driven IRAs. As IRAs proliferate in the advertising field, the findings offer implications that can enable advertisers and advertising academics and practitioners to better targeted audiences and enhance customer relationships. | Kim, Juran; Kang, Seungmook; Bae, Joonheui | Jeonju Univ, Dept Business Adm, 518 Res Bldg 303 Cheonjamro, Jeonju 55069, Jeonbuk, South Korea; Jeonju Univ, Dept Game Contents, Arts Hall Annex Room 303,303 Cheonjamro, Jeonju 55069, Jeonbuk, South Korea; Kyungpook Natl Univ, Sch Business Adm, Daegu, South Korea | Bae, Joonheui/JXM-6789-2024 | 24074436200; 57210973804; 57202349513 | jrkim@jj.ac.kr;xevious@jj.ac.kr;regina721@knu.ac.kr; | INTERNATIONAL JOURNAL OF ADVERTISING | INT J ADVERT | 0265-0487 | 1759-3948 | 41 | 6 | SSCI | BUSINESS;COMMUNICATION | 2022 | 6.7 | 5.7 | 1.5 | 2025-06-25 | 15 | 15 | Artificial intelligence; interactive recommendation agent; Stitch Fix; consumption goals; AI-driven IRA value | NORMATIVE CONDUCT; FOCUS THEORY; CONSUMER; MOTIVATION; PRODUCT; BRAND; PERSONALIZATION; ATTITUDES; PRIVACY; IMPACT | AI-driven IRA value; Artificial intelligence; consumption goals; interactive recommendation agent; Stitch Fix | English | 2022 | 2022-08-18 | 10.1080/02650487.2021.1963098 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Understanding the role of construal level in time-restriction | Understanding how time restriction impacts consumers has been an important long-term topic for both scholars and practitioners. Applying a Construal Level Theory framework, two experiments were designed to propose a new theoretical perspective regarding the mechanism of time restriction. Testing moderators of advertising appeals and message quality, the study aimed to identify the conditions under which time restriction is more effective in influencing consumers' response. In study 1, a factorial 2 x 2 design (time restriction: yes vs. no x advertising appeal: collectivistic vs. individualistic) between subjects was employed using a student sample and a high-involvement product. In study 2, another factorial 2 x 2 design (time restriction: yes vs. no x advertising appeal: guilt vs. shame) between subjects was employed using a general population and a low-involvement product. The findings of the two studies confirmed the mediating role of construal level in explaining consumers' purchase intention and the moderating role of message quality. Specifically, the effects found for study 1 appeared to be more pronounced for subjects exposed to the collectivistic appeal. Theoretical and managerial implications were discussed for researchers and practitioners. | Kim, Hyuksoo; Cheong, Yunjae; Kim, Kihan | Kyungpook Natl Univ, Coll Econ & Business Adm, Sch Business Adm, 80 Daehakro, Daegu 41566, South Korea; Hankuk Univ Foreign Studies, Div Media Commun, Seoul, South Korea; Seoul Natl Univ, Dept Phys Educ, Sport Management, Seoul, South Korea | iumyum@knu.ac.kr; | INTERNATIONAL JOURNAL OF ADVERTISING | INT J ADVERT | 0265-0487 | 1759-3948 | 41 | 7 | SSCI | BUSINESS;COMMUNICATION | 2022 | 6.7 | 5.7 | 6 | Construal level; time restriction; collectivistic; individualistic; shame; guilt; message quality | PSYCHOLOGICAL DISTANCE; ADVERTISING APPEALS; GUILT; SHAME; BEHAVIOR; SELF; COGNITION; CULTURE; INDIVIDUALISM; CREDIBILITY | English | 2022 | 2022-09-14 | 10.1080/02650487.2021.2022290 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Validation of the revised diagnostic criteria for primary plasma cell leukemia by the Korean Multiple Myeloma Working Party | The International Myeloma Working Group has recently revised the diagnostic criteria for primary plasma cell leukemia (PCL) to circulating plasma cells (CPCs) >= 5% in a peripheral blood smear. The present study validated new criteria in patients with multiple myeloma or PCL diagnosed using the previous diagnostic criteria, who were administered immunomodulatory drugs or proteasome inhibitors as induction therapy. We analyzed the medical records of 1357 patients from eight hospitals in South Korea. The median age of the all patients was 64 years, and 187 (13.8%) had CPCs at diagnosis. Only 79 (5.8%) of the patients had >= 5% CPCs. The median overall survival (OS) of patients with CPCs >= 5% and >= 20% was similar, but had significantly inferior median progression-free survival (PFS) and median OS than those with CPCs = 5% in a peripheral blood smear is appropriate for PCL diagnosis. | Jung, Sung-Hoon; Kim, Kihyun; Yoon, Sang Eun; Moon, Joon Ho; Kim, Dajung; Kim, Hyo Jung; Kim, Min Kyoung; Ha Kim, Kyoung; Lee, Hyun Jung; Lee, Ji Hyun; Kim, Sung-Hyun; Yoo, Kawi Han; Lee, Jae Hoon; Lee, Je-Jung | Chonnam Natl Univ, Hwasun Hosp, Med Sch, Hwasun, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Daegu, South Korea; Kosin Univ, Gospel Hosp, Busan, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Yeungnam Univ, Med Ctr, Daegu, South Korea; Soonchunhyang Univ, Dept Internal Med, Seoul Hosp, Seoul, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Coll Med, Seoul, South Korea; Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea; Gachon Univ, Gil Med Ctr, Incheon, South Korea | ; Kim, Min/ACN-6827-2022; Lee, Jeong Won/AAC-4169-2022; Kim, Hyo/AAQ-3152-2020; Lee, Jung-Hye/F-6974-2013; Lee, Jeong/JFA-4725-2023; Kim, Kihyun/D-5175-2013 | 55511978300; 57199440300; 57205167470; 56568642700; 57195951981; 7410139194; 57206000629; 7409319096; 57218175082; 56813113800; 56547959500; 57971045200; 56013463700; 7601478211 | kihyunkimk@gmail.com;drjejung@chonnam.ac.kr; | BLOOD CANCER JOURNAL | BLOOD CANCER J | 2044-5385 | 12 | 11 | SCIE | HEMATOLOGY;ONCOLOGY | 2022 | 12.8 | 5.7 | 0.98 | 2025-06-25 | 10 | 10 | TRANSPLANTATION; DEXAMETHASONE | Humans; Leukemia, Plasma Cell; Middle Aged; Multiple Myeloma; Plasmacytoma; Proteasome Inhibitors; beta 2 microglobulin; bortezomib; calcium; carfilzomib; creatinine; daratumumab; dexamethasone; ixazomib; lenalidomide; melphalan; prednisolone; prednisone; thalidomide; proteasome inhibitor; adult; aged; Article; autologous stem cell transplantation; blood smear; calcium blood level; cancer immunotherapy; cancer prognosis; cancer survival; controlled study; creatinine blood level; female; human; International Staging System; major clinical study; male; medical record review; multiple myeloma; overall survival; plasma cell leukemia; plasmacytoma; platelet count; progression free survival; protein blood level; South Korea; validation study; middle aged; multiple myeloma; plasma cell leukemia; plasmacytoma | English | 2022 | 2022-11-21 | 10.1038/s41408-022-00755-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Effect of Structural Fine-Tuning on Chelate Stability and LiverUptake of Anionic MRI Contrast Agents | The purpose of this study is to assess the physicochemical propertiesand MRI diagnostic efficacy of two newly synthesized 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-type Gd chelates, Gd-SucL and Gd-GluL, with anasymmetric alpha-substituted pendant arm as potential hepatocyte-specific magneticresonance imaging contrast agents (MRI CAs). Ourfindings show thatfineconformational changes in the chelating arm affect thein vivopharmacokineticbehavior of the MRI CA, and that a six-membered chelating substituent of Gd-SucL ismore advantageous in this system to avoid unwanted interactions with endogenousspecies. Gd-SucL exhibited a general DOTA-like chelate stability trend, indicating thatall chelating arms retain coordination bonding. Finally, thein vivodiagnostic efficacy ofhighly stable Gd-SucL as a potential hepatocyte-specific MRI CA was evaluated usingT1-weighted MR imaging on an orthotopic hepatocarcinoma model. | Baek, Ah Rum; Kim, Hee-Kyung; Kim, Soyeon; Yang, Ji-ung; Kang, Min-Kyoung; Lee, Jae Jun; Sung, Bokyung; Lee, Hyeji; Kim, Minsup; Cho, Art E.; Park, Ji-Ae; Chang, Yongmin | Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41405, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Preclin Res Ctr, Daegu 41061, South Korea; Korea Inst Radiol & Med Sci, Div RI Convergence Res, Seoul 139706, South Korea; KBIO Osong Med Innovat Fdn, Lab Anim Ctr, Osong 28160, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Biomed Sci, Daegu 419944, South Korea; InCerebro Drug Discovery Inst, Seoul 01811, South Korea; Kyungpook Natl Univ, Sch Med, Dept Med & Biol Engn, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea | 57194601711; 56014729400; 57203773250; 57212217968; 55904412800; 56467498000; 58929528400; 57654051800; 56122945800; 8586262300; 16319690600; 7501840633 | jpark@kirams.re.kr;ychang@knu.ac.kr; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 65 | 8 | SCIE | CHEMISTRY, MEDICINAL | 2022 | 7.3 | 5.8 | 0.79 | 2025-06-25 | 8 | 8 | PROTEIN-BINDING; HIGH RELAXIVITY; SERUM-ALBUMIN; GADOLINIUM COMPLEX; LIVER; SELECTIVITY; CONJUGATE; DESIGN | Anions; Chelating Agents; Contrast Media; Gadolinium; Liver; Magnetic Resonance Imaging; gadobenate dimeglumine; gadobutrol; gadolinium chelate; gadolinium pentetate meglumine; gadoterate meglumine; gadoxetic acid; human serum albumin; nuclear magnetic resonance imaging agent; anion; chelating agent; contrast medium; gadolinium; animal experiment; animal model; Article; chelation; computer model; conformational transition; controlled study; drug distribution; drug liver level; human; human cell; in vivo study; lipophilicity; liver cell carcinoma; male; metallation; molecular docking; molecular stability; mouse; nonhuman; nuclear magnetic resonance imaging; physical chemistry; structure activity relation; T1 weighted imaging; T2 weighted imaging; chemistry; diagnostic imaging; liver; nuclear magnetic resonance imaging; procedures | English | 2022 | 2022-04-28 | 10.1021/acs.jmedchem.2c00291 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14 | Apoptotic cells are rapidly engulfed and removed by phagocytes after displaying cell surface eat-me signals. Among many phospholipids, only phosphatidylserine (PS) is known to act as an eat-me signal on apoptotic cells. Using unbiased proteomics, we identified externalized phosphatidylinositides (PIPs) as apoptotic eat-me signals recognized by CD14(+) phagocytes. Exofacial PIPs on the surfaces of early and late-apoptotic cells were observed in patches and blebs using anti-PI(3,4,5)P-3 antibody, AKT- and PLC delta PH-domains, and CD14 protein. Phagocytosis of apoptotic cells was blocked either by masking exofacial PIPs or by CD14 knockout in phagocytes. We further confirmed that exofacial PIP+ thymocytes increased dramatically after in vivo irradiation and that exofacial PIP+ cells represented more significant populations in tissues of Cd14(-/-) than WT mice, especially after induction of apoptosis. Our findings reveal exofacial PIPs to be previously unknown cell death signals recognized by CD14(+) phagocytes. | Kim, Ok-Hee; Kang, Geun-Hyung; Hur, June; Lee, Jinwook; Jung, YunJae; Hong, In-Sun; Lee, Hookeun; Seo, Seung-Yong; Lee, Dae Ho; Lee, Cheol Soon; Lee, In-Kyu; Bonner-Weir, Susan; Lee, Jongsoon; Park, Young Joo; Kim, Hyeonjin; Shoelson, Steven E.; Oh, Byung-Chul | Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Dept Physiol, Coll Med, Incheon 21999, South Korea; Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Dept Microbiol, Coll Med, Incheon 21999, South Korea; Gachon Univ, Lee Gil Ya Canc & Diabet Inst, Dept Mol Med, Coll Med, Incheon 21999, South Korea; Gachon Univ, Coll Pharm, Incheon 21936, South Korea; Gachon Univ, Dept Internal Med, Gil Med Ctr, Incheon 21565, South Korea; Korea Univ, Med Hlth Res Ctr, Coll Med, Seoul 02841, South Korea; Kyungpook Natl Univ, Grad Sch Med, Dept Biomed Sci, Daegu 41404, South Korea; Harvard Med Sch, Joslin Diabet Ctr, One Joslin Pl, Boston, MA 02215 USA; Harvard Med Sch, Dept Med, One Joslin Pl, Boston, MA 02215 USA; Soonchunhyang Inst Medi Bio Sci SIMS, Cheonan Si 31151, South Korea; Seoul Natl Univ Hosptial, Dept Internal Med, Seoul 03080, South Korea; Seoul Natl Univ, Dept Radiol, Coll Med, Seoul 03080, South Korea | ; Lee, Cheol Soon/LKJ-5985-2024; Lee, Heon-Jeong/K-5871-2015; Lee, In-Kyu/AAR-6374-2021; bonner-weir, susan/IYS-2699-2023; LEE, WON-YOUNG/C-7249-2018; Lee, Jongsoon/AAG-1674-2020 | 36463666400; 57217456535; 57196955323; 57196940896; 23481503600; 15074102100; 7501482156; 7202469894; 56228667700; 57216180306; 36071537600; 7004956606; 57203144292; 57049715800; 56283348300; 7005691609; 7202848469 | steven.shoelson@joslin.harvard.edu;bcoh@gachon.ac.kr; | CELL DEATH AND DIFFERENTIATION | CELL DEATH DIFFER | 1350-9047 | 1476-5403 | 29 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2022 | 12.4 | 5.8 | 1.52 | 2025-06-25 | 18 | 18 | CD14-DEPENDENT CLEARANCE; PHOSPHATIDYLSERINE; PHOSPHOINOSITIDES; BINDING; DEATH; PHOSPHORYLATION; PHAGOCYTOSIS; INFLAMMATION; ENDOCYTOSIS; EXPOSURE | Animals; Apoptosis; Mice; Phagocytes; Phagocytosis; Phosphatidylserines; Signal Transduction; CD14 antigen; inositol phosphate; phosphatidylinositide; phosphatidylinositide antibody; phospholipase C delta; phospholipid antibody; protein kinase B; unclassified drug; phosphatidylserine; animal cell; animal experiment; antigen binding; apoptosis; Article; cell death; cell fate; cell growth; cell phagocytosis; cell population; cell surface; cell survival; cell transport; controlled study; eat me signal; gene knockout; human; human cell; in vivo study; macrophage; mouse; nonhuman; phagocyte; protein domain; proteomics; signal transduction; wild type mouse; animal; apoptosis; metabolism; phagocytosis; physiology | English | 2022 | 2022-07 | 10.1038/s41418-022-00931-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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