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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | QCT-based Measures Of Airway Narrowing And Shape Changes Associated With Endobronchial Biopsy Tissue Measures of Airway Remodeling And Clinical Outcomes In Asthma | Choi, Jiwoong; Boomer, Jonathan; Lee, In Kyu; Shi, Fred; Christenson, Stephanie; Nguyen, Jenna; Bacharier, Leonard; Woodruff, Prescott; Peters, Michael; Choi, Sanghun; Lin, Ching-Long; Castro, Mario | Univ Kansas, Sch Med, Kansas City, KS USA; Univ Kansas, Lawrence, KS USA; Washington Univ, Sch Med, St Louis, MO USA; Univ Calif San Francisco, Sch Med, San Francisco, CA USA; Univ Calif San Francisco, San Francisco, CA USA; KyungPook Natl Univ, Daegu, South Korea; Univ Iowa, Iowa City, IA USA | Shi, Xiaosong/KHZ-2313-2024; Choi, Sanghun/AGS-7430-2022; Castro, Mario/ABD-7776-2021 | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | J ALLERGY CLIN IMMUN | 0091-6749 | 1097-6825 | 147 | 2 | SCIE | ALLERGY;IMMUNOLOGY | 2021 | 14.29 | 5.4 | 0 | English | 2021 | 2021-02 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Ultrasonic assisted exfoliation for efficient production of RuO2 monolayer nanosheets | Two-dimensional (2D) metal oxide nanosheets have been synthesized through ion exchange reactions. However, they require a long time and lead to low production yields due to the molecular size of the intercalant and reaction activation energies. To reduce the processing time and accelerate the production yield, we introduce an ultrasonically supported ion exchange reaction process. We applied ultrasound energy on the solution of RuO2 nanosheets and the intercalant after 3 days of stirring the ion exchange reaction. After 15 min, the yield of RuO2 nanosheets increased by over 50%. In addition, we observed that the lateral size of the RuO2 nanosheets decreased with the applied ultrasonic time. Density functional theory calculations demonstrated that the activation energy of exfoliation is significantly reduced by splitting the RuO2 layers into a small lateral size. This result shows that ultrasound provides energy for 15 min of exfoliation of the RuO2 nanosheets, after which the energy is used to break the RuO2 nanosheets. The experimental and theoretical results suggest that an ultrasonic-supported ion exchange process offers a facile and efficient approach for fabricating 2D metal oxide nanosheets. | Kim, Se Yun; Kim, Sang-il; Kim, Mun Kyoung; Kim, Jinhong; Mizusaki, Soichiro; Ko, Dong-Su; Jung, Changhoon; Yun, Dong-Jin; Roh, Jong Wook; Kim, Hyun-Sik; Sohn, Hiesang; Lim, Jong-Hyeong; Oh, Jong-Min; Jeong, Hyung Mo; Shin, Weon Ho | Samsung Adv Inst Technol, Inorgan Mat Lab, Suwon 16678, South Korea; Univ Seoul, Dept Mat Sci & Engn, Seoul 02504, South Korea; Sungkyunkwan Univ, Sch Mech Engn, Suwon 16419, South Korea; Sungkyunkwan Univ, Dept Smart Fab Technol, Suwon 16419, South Korea; Samsung Adv Inst Technol, Autonomous Mat Dev Lab, Suwon 16678, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Sangju 37224, South Korea; Hongik Univ, Dept Mat Sci & Engn, Seoul 04066, South Korea; Kwangwoon Univ, Dept Chem Engn, Seoul 01897, South Korea; Kwangwoon Univ, Dept Elect Mat Engn, Seoul 01897, South Korea | Sohn, Hiesang/F-8518-2011; Shin, Weon/AAH-4031-2020; Ko, Dong-Su/AAZ-5644-2020; Kim, Seung/N-5248-2019; Kim, Sung/A-4747-2013 | 57203210313; 36171889900; 57202767289; 57221537356; 12646641100; 25641304500; 55747781500; 22935923900; 25638796100; 56526077500; 55158873100; 57219655127; 35219258600; 42061388000; 57204152565 | hmjeong@skku.edu;weonho@kw.ac.kr; | INORGANIC CHEMISTRY FRONTIERS | INORG CHEM FRONT | 2052-1553 | 8 | 20 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2021 | 7.779 | 5.4 | 0.55 | 2025-07-30 | 6 | 8 | RUTHENATE; BEHAVIOR; LAYER | Activation energy; Defects; Density functional theory; Exfoliation (materials science); Ions; Metals; Ruthenium compounds; Ultrasonics; Energy; Intercalants; Ion exchange reactions; Lateral sizes; Metal oxide nanosheets; Molecular size; Processing time; Production yield; Synthesised; Two-dimensional; Nanosheets | English | 2021 | 2021-10-12 | 10.1039/d1qi00652e | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | The insulin signaling pathway in Drosophila melanogaster: A nexus revealing an "Achilles' heel" in DDT resistance | Insecticide resistance is an ongoing challenge in agriculture and disease vector control. Here, we demonstrate a novel strategy to attenuate resistance. We used genomics tools to target fundamental energy-associated pathways and identified a potential "Achilles' heel" for resistance, a resistance-associated protein that, upon inhibition, results in a substantial loss in the resistance phenotype. Specifically, we compared the gene expression profiles and structural variations of the insulin/insulin-like growth factor signaling (IIS) pathway genes in DDT-susceptible (91-C) and -resistant (91-R) Drosophila melanogaster (Drosophila) strains. A total of eight and seven IIS transcripts were up- and down-regulated, respectively, in 91-R compared to 91-C. A total of 114 nonsynonymous mutations were observed between 91-C and 91-R, of which 51.8% were fixed. Among the differentially expressed transcripts, phosphoenolpyruvate carboxykinase (PEPCK), down-regulated in 91-R, encoded the greatest number of amino acid changes, prompting us to perform PEPCK inhibitor-pesticide exposure bioassays. The inhibitor of PEPCK, hydrazine sulfate, resulted in a 161- to 218-fold decrease in the DDT resistance phenotype (91-R) and more than a 4- to 5-fold increase in susceptibility in 91-C. A second target protein, Glycogen synthase kinase 3 beta (GSK3 beta-PO), had one amino acid difference between 91-C and 91-R, and the corresponding transcript was also down-regulated in 91-R. A GSK3 beta-PO inhibitor, lithium chloride, likewise reduced the resistance but to a lesser extent than did hydrazine sulfate for PEPCK. We demonstrate the potential role of IIS genes in DDT resistance and the potential discovery of an "Achilles' heel" against pesticide resistance in this pathway. | Zhang, Can; Seong, Keon Mook; Sun, Weilin; Mittapalli, Omprakash; Qiu, Baoli; Clark, John M.; Pittendrigh, Barry R. | Guangdong Ecoengn Polytech, Dept Ecoengn, Guangzhou 510520, Peoples R China; Michigan State Univ, Dept Entomol, E Lansing, MI 48824 USA; Kyungpook Natl Univ, Dept Appl Biol, Coll Ecol & Environm, Sangju, South Korea; Univ Kentucky, Dept Entomol, Lexington, KY 40506 USA; South China Agr Univ, Dept Entomol, Guangzhou 510640, Peoples R China; Univ Massachusetts, Dept Vet & Anim Sci, Amherst, MA 01003 USA | Sun, Wei Lin/JMB-5547-2023 | 57192559336; 26635871000; 55726591200; 8593251100; 8670537900; 7407829142; 7004045385 | pittendr@msu.edu; | PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | PESTIC BIOCHEM PHYS | 0048-3575 | 1095-9939 | 171 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY | 2021 | 4.966 | 5.5 | 0.39 | 2025-07-30 | 7 | 6 | Drosophila melanogaster; IIS (insulin/insulin-like growth factor signaling pathway); DDT resistance; Pest control | PHOSPHOENOLPYRUVATE CARBOXYKINASE; 91-R STRAIN; LIFE-SPAN; ORGANOCHLORINE PESTICIDES; LIPID-PEROXIDATION; ADIPOSE-TISSUE; EXPRESSION; TRANSCRIPTION; METABOLISM; GROWTH | DDT resistance; Drosophila melanogaster; IIS (insulin/insulin-like growth factor signaling pathway); Pest control | Animals; DDT; Drosophila melanogaster; Drosophila Proteins; Heel; Insecticide Resistance; Insulin; Signal Transduction; chlorphenotane; Drosophila protein; insulin; animal; Drosophila melanogaster; genetics; heel; insecticide resistance; metabolism; signal transduction | English | 2021 | 2021-01 | 10.1016/j.pestbp.2020.104727 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Acetylated Resveratrol and Oxyresveratrol Suppress UVB-Induced MMP-1 Expression in Human Dermal Fibroblasts | Resveratrol (RES) and oxyresveratrol (OXYRES) are considered and utilized as active ingredients of anti-aging skin cosmetics. However, these compounds are susceptible to oxidative discoloration and unpleasant odor in solutions, limiting their use in cosmetics. Accordingly, RES and OXYRES were chemically modified to acetylated derivatives with enhanced stability, and their anti-aging effect on the skin and detailed molecular mechanism of their acetylated derivatives were investigated. Acetylated RES and OXYRES lost their acetyl group and exerted an inhibitory effect on H2O2-induced ROS levels in human dermal fibroblast (HDF) cells. In addition, RES, OXYRES, and their acetylated derivatives suppressed UVB-induced matrix metalloproteinase (MMP)-1 expression via inhibition of mitogen-activated protein kinases (MAPKs) and Akt/mTOR signaling pathways. Furthermore, RES, OXYRES, and their acetylated derivatives suppressed type I collagen in TPA-treated HDF cells. Collectively, these results suggest the beneficial effects and underlying molecular mechanisms of RES, OXYRES, and their acetylated derivatives for anti- skin aging applications. | Lee, Jae-Eun; Oh, Jijeong; Song, Daeun; Lee, Mijeong; Hahn, Dongyup; Boo, Yong Chool; Kang, Nam Joo | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Integrat Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, BK21 Plus KNU Biomed Convergence Program, Dept Mol Med,Cell & Matrix Res Inst, Daegu 41944, South Korea | 57203144423; 57226491791; 57226501422; 57213600224; 36554163400; 6602899130; 8315288500 | lju1033@naver.com;ojjeong0113@hanmail.net;sde940902@naver.com;lmj7083@hanmail.net;dohahn@knu.ac.kr;ycboo@knu.ac.kr;njkang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 1.08 | 2025-07-30 | 13 | 14 | resveratrol; oxyresveratrol; acetylated derivative; matrix metalloproteinase-1; type I collagen; ultraviolet B; skin aging | MATRIX METALLOPROTEINASES; HUMAN KERATINOCYTES; OXIDATIVE STRESS; ANTIOXIDANT; INHIBITION; DAMAGE; PROLIFERATION; ACTIVATION; MECHANISMS; STRATEGIES | Acetylated derivative; Matrix metalloproteinase-1; Oxyresveratrol; Resveratrol; Skin aging; Type I collagen; Ultraviolet B | English | 2021 | 2021-08 | 10.3390/antiox10081252 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Analysis of the Chemical, Antioxidant, and Anti-Inflammatory Properties of Pink Pepper (Schinus molle L.) | Here, we compared the chemical properties and antioxidant effects of black pepper (Piper nigrum L.) and pink pepper (Schinus molle L.). Additionally, the antioxidant and anti-inflammatory capacities of pink pepper were measured to determine nutraceutical potential. Pink peppers from Brazil (PPB), India (PPI), and Sri Lanka (PPS) had higher Hunter a* (redness) values and lower L* (lightness) and b* (yellowness) values than black pepper from Vietnam (BPV). Fructose and glucose were detected in PPB, PPI, and PPS, but not in BPV. PPB, PPI, and PPS had greater 2,2-diphenyl-1-picrylhydrazyl and 3-ethylbenzothiazoline-6-sulphonic acid radical scavenging stabilities and higher total phenolic contents than BPV. BPV had higher levels of piperine than the pink peppers. Gallic acid, protocatechuic acid, epicatechin, and p-coumaric acid were detected only in the three pink peppers. PPB significantly suppressed lipopolysaccharide-induced reactive oxygen species production with increased Nrf2 translocation from cytosol to nucleus and heme oxygenase-1 expression. PPB and PPS significantly suppressed lipopolysaccharide-induced nitrite production and nitric oxide synthase expression by suppressing phosphorylation of p38 without affecting cell viability. Additionally, PPB and PPS significantly suppressed ultraviolet B-induced cyclooxygenase-2 expression by affecting the phosphorylation of ERK1/2 without cell cytotoxicity. These results suggest that pink pepper is a potential nutraceutical against oxidative and inflammatory stress. | Kim, Min Jeong; Kim, Dae Won; Kim, Ju Gyeong; Shin, Youngjae; Jung, Sung Keun; Kim, Young-Jun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Seoul Natl Univ Sci & Technol, Dept Food Sci & Technol, Seoul 01811, South Korea; Dankook Univ, Dept Food Engn, Cheonan 31116, Chungnam, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | ; Jung, SUNG KEUN/AGR-2623-2022; Kim, Joo/X-7562-2019 | 57215818497; 57216224891; 57216640718; 17342820900; 35310491400; 57211016047 | excellent8@knu.ac.kr;kdw3566@seoultech.ac.kr;jgrla23@gmail.com;ys234@dankook.ac.kr;skjung04@knu.ac.kr;kimyj@seoultech.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 0.85 | 2025-07-30 | 13 | 16 | nutraceutical; compound compositions; reactive oxygen species; mitogen-activated protein kinase; nuclear factor kappa-light-chain-enhancer of activated B cells | FREE-RADICALS; TEREBINTHIFOLIUS; DIFFERENTIATION; INFLAMMATION; INHIBITION; EXTRACT; CANCER; FRUITS; MS | Compound compositions; Mitogen-activated protein kinase; Nuclear factor kappa-light-chain-enhancer of activated B cells; Nutraceutical; Reactive oxygen species | English | 2021 | 2021-07 | 10.3390/antiox10071062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Arbutin as a Skin Depigmenting Agent with Antimelanogenic and Antioxidant Properties | Arbutin is a compound of hydroquinone and D-glucose, and it has been over 30 years since there have been serious studies on the skin lightening action of this substance. In the meantime, there have been debates and validation studies about the mechanism of action of this substance as well as its skin lightening efficacy and safety. Several analogs or derivatives of arbutin have been developed and studied for their melanin synthesis inhibitory action. Formulations have been developed to improve the stability, transdermal delivery, and release of arbutin, and device usage to promote skin absorption has been developed. Substances that inhibit melanin synthesis synergistically with arbutin have been explored. The skin lightening efficacy of arbutin alone or in combination with other active ingredients has been clinically evaluated. Combined therapy with arbutin and laser could give enhanced depigmenting efficacy. The use of arbutin causes dermatitis rarely, and caution is recommended for the use of arbutin-containing products, especially from the viewpoint that hydroquinone may be generated during product use. Studies on the antioxidant properties of arbutin are emerging, and these antioxidant properties are proposed to contribute to the skin depigmenting action of arbutin. It is hoped that this review will help to understand the pros and cons of arbutin as a cosmetic ingredient, and will lead to future research directions for developing advanced skin lightening and protecting cosmetic products. | Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Mol Med,BK21 Plus KNU Biomed Convergence Pro, Daegu 41944, South Korea | 6602899130 | ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 3.47 | 2025-07-30 | 123 | 142 | arbutin; melanin; pigment; melasma; skin lightening; cosmetic; hyperpigmentation; tyrosinase; antioxidant; nuclear factor erythroid 2-related factor 2 (Nrf2) | CONSUMER SAFETY SCCS; ALPHA-ARBUTIN; TYROSINASE ACTIVITY; ENZYMATIC-SYNTHESIS; LEUCONOSTOC-MESENTEROIDES; MELANIN BIOSYNTHESIS; SCIENTIFIC COMMITTEE; TRANSCRIPTION FACTOR; PHENOLIC-COMPOUNDS; BETA-ARBUTIN | Antioxidant; Arbutin; Cosmetic; Hyperpigmentation; Melanin; Melasma; Nuclear factor erythroid 2-related factor 2 (Nrf2); Pigment; Skin lightening; Tyrosinase | English | 2021 | 2021-07 | 10.3390/antiox10071129 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Aronia melanocarpa Extract Fermented by Lactobacillus plantarum EJ2014 Modulates Immune Response in Mice | The present study aimed to assess the immunomodulatory effects of fermented Aronia melanocarpa extract (FAME) on RAW 264.7 cells and BALB/c mice. Aronia melanocarpa fruit was fermented with Lactobacillus plantarum EJ2014 by adding yeast extract and monosodium glutamate for 9 days at 30 degrees C to produce gamma-aminobutyric acid (GABA). After fermentation, significant GABA production was noted, along with minerals, polyphenols, and flavonoids (p < 0.05). The polyphenol content was confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis. RAW 264.7 cells were stimulated with lipopolysaccharide (LPS, 1 mu g/mL) in the presence or absence of FAME, and proinflammatory cytokine contents were measured by qPCR. In the in vivo experiment, female BALB/c mice were administered 125, 250, and 500 mg/kg of FAME for 21 days. FAME treatment increased neutrophil migration and phagocytosis (p < 0.05). It also increased splenocyte proliferation, CD4(+) and CD8(+) T-cell expression, and lymphocyte proliferation. Furthermore, it increased IFN-gamma, IL-2, and IL-4 cytokine levels in a dose-dependent manner (p < 0.05). However, it decreased TNF-alpha and IL-6 levels (p < 0.05). These results indicate that FAME fortified with GABA including bioactive compounds exerts anti-inflammatory effects by inhibiting proinflammatory cytokines in RAW 264.7 cells and modulates immune response in mice. Thus, FAME could be a potential therapeutic agent for inflammatory disorders. | Ali, Md Sekendar; Lee, Eon-Bee; Lee, Seung-Jin; Lee, Sam-Pin; Boby, Naila; Suk, Kyoungho; Birhanu, Biruk Tesfaye; Park, Seung-Chun | Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Brain Sci & Engn Inst, Dept Pharmacol, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Daegu 41566, South Korea; Int Islamic Univ Chittagong, Dept Pharm, Kumira 4318, Chittagong, Bangladesh; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea; Keimyung Univ, Dept Food Sci & Technol, Daegu 42601, South Korea | Lee, Jung Bok/HHZ-3200-2022; Park, Seung-Chun/AAV-3388-2021; Birhanu, Biruk/F-1622-2017; Lee, Jun Young/CAI-2335-2022; Boby, Naila/GRE-8096-2022 | 57219661221; 57216526135; 58689440900; 57216647188; 57197787296; 7005114595; 56996190000; 7501832396 | alipharm2000@gmail.com;eonbee@gmail.com;dvmleesj@naver.com;splee@knu.ac.kr;nailaboby@knu.ac.kr;ksuk@knu.ac.kr;btbtes@gmail.com;parksch@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 1.08 | 2025-07-30 | 16 | 19 | Aronia melanocarpa; Lactobacillus plantarum; fermentation; GABA; polyphenols; RAW 264; 7 cells; proinflammatory cytokines; immunomodulation | GAMMA-AMINOBUTYRIC-ACID; ANTIOXIDANT ACTIVITY; ANTIINFLAMMATORY ACTIVITIES; FLAVONOIDS; GABA; ACTIVATION; QUERCETIN; HEALTH; FOODS; JUICE | Aronia melanocarpa; Fermentation; GABA; Immunomodulation; Lactobacillus plantarum; Polyphenols; Proinflammatory cytokines; RAW 264.7 cells | English | 2021 | 2021-08 | 10.3390/antiox10081276 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Current Perspectives on the Beneficial Effects of Soybean Isoflavones and Their Metabolites for Humans | Soybeans are rich in proteins and lipids and have become a staple part of the human diet. Besides their nutritional excellence, they have also been shown to contain various functional components, including isoflavones, and have consequently received increasing attention as a functional food item. Isoflavones are structurally similar to 17-beta-estradiol and bind to estrogen receptors (ER alpha and ER beta). The estrogenic activity of isoflavones ranges from a hundredth to a thousandth of that of estrogen itself. Isoflavones play a role in regulating the effects of estrogen in the human body, depending on the situation. Thus, when estrogen is insufficient, isoflavones perform the functions of estrogen, and when estrogen is excessive, isoflavones block the estrogen receptors to which estrogen binds, thus acting as an estrogen antagonist. In particular, estrogen antagonistic activity is important in the breast, endometrium, and prostate, and such antagonistic activity suppresses cancer occurrence. Genistein, an isoflavone, has cancer-suppressing effects on estrogen receptor-positive (ER+) cancers, including breast cancer. It suppresses the function of enzymes such as tyrosine protein kinase, mitogen-activated kinase, and DNA polymerase II, thus inhibiting cell proliferation and inducing apoptosis. Genistein is the most biologically active and potent isoflavone candidate for cancer prevention. Furthermore, among the various physiological functions of isoflavones, they are best known for their antioxidant activities. S-Equol, a metabolite of genistein and daidzein, has strong antioxidative effects; however, the ability to metabolize daidzein into S-equol varies based on racial and individual differences. The antioxidant activity of isoflavones may be effective in preventing dementia by inhibiting the phosphorylation of Alzheimer's-related tau proteins. Genistein also reduces allergic responses by limiting the expression of mast cell IgE receptors, which are involved in allergic responses. In addition, they have been known to prevent and treat various diseases, including cardiovascular diseases, metabolic syndromes, osteoporosis, diabetes, brain-related diseases, high blood pressure, hyperlipidemia, obesity, and inflammation. Further, it also has positive effects on menstrual irregularity in non-menopausal women and relieving menopausal symptoms in middle-aged women. Recently, soybean consumption has shown steep increasing trend in Western countries where the intake was previously only 1/20-1/50 of that in Asian countries. In this review, Ihave dealt with the latest research trends that have shown substantial interest in the biological efficacy of isoflavones in humans and plants, and their related mechanisms. | Kim, Il-Sup | Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea | 55477678200 | 92kis@hanmail.net; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 7 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 5.48 | 2025-07-30 | 192 | 215 | soybean-derived isoflavones; physiological effect; gene regulation; health benefit mechanism | ANTIOXIDANT ENZYME-ACTIVITIES; RANDOMIZED CONTROLLED-TRIAL; SOY PROTEIN ISOLATE; FATTY LIVER-DISEASE; QUALITY-OF-LIFE; POSTMENOPAUSAL WOMEN; BREAST-CANCER; PROSTATE-CANCER; BLOOD-PRESSURE; OXIDATIVE STRESS | Gene regulation; Health benefit mechanism; Physiological effect; Soybean-derived isoflavones | English | 2021 | 2021-07 | 10.3390/antiox10071064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress | Alcoholic liver disease (ALD) is a major liver disease worldwide and can range from simple steatosis or inflammation to fibrosis/cirrhosis, possibly through leaky gut and systemic endotoxemia. Many patients with alcoholic steatohepatitis (ASH) die within 60 days after clinical diagnosis due to the lack of an approved drug, and thus, synthetic and/or dietary agents to prevent ASH and premature deaths are urgently needed. We recently reported that a pharmacologically high dose of pomegranate extract prevented binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. Herein, we investigate whether a dietary antioxidant ellagic acid (EA) contained in many fruits, including pomegranate and vegetables, can protect against binge alcohol-induced leaky gut, endotoxemia, and liver inflammation. Pretreatment with a physiologically-relevant dose of EA for 14 days significantly reduced the binge alcohol-induced gut barrier dysfunction, endotoxemia, and inflammatory liver injury in mice by inhibiting gut dysbiosis and the elevated oxidative stress and apoptosis marker proteins. Pretreatment with EA significantly prevented the decreased amounts of gut tight junction/adherent junction proteins and the elevated gut leakiness in alcohol-exposed mice. Taken together, our results suggest that EA could be used as a dietary supplement for alcoholic hepatitis patients. | Kim, Dong-ha; Sim, Yejin; Hwang, Jin-hyeon; Kwun, In-Sook; Lim, Jae-Hwan; Kim, Jihoon; Kim, Jee-In; Baek, Moon-Chang; Akbar, Mohammed; Seo, Wonhyo; Kim, Do-Kyun; Song, Byoung-Joon; Cho, Young-Eun | Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea; Andong Natl Univ, Dept Biol Sci, Andong 36729, South Korea; Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA; Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Mol Med, Daegu 41944, South Korea; Natl Inst Alcohol Abuse & Alcoholism, Div Neurosci & Behav, Bethesda, MD 20892 USA; Ewha Womans Univ, Grad Sch Pharmaceut Sci, Coll Pharm, Seoul 03760, South Korea; Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea; NIAAA, Natl Inst Hlth Bethesda, Lab Membrane Biochem & Biophys, Sect Mol Pharmacol & Toxicol, Bethesda, MD 20892 USA | Kim, Jihoon/GQP-4563-2022; Kim, Dongha/HNO-9659-2023; Akbar, Muhamad/D-8158-2019; Wang, Xiaolin/ADQ-6971-2022 | 57219014701; 57220600274; 57219012305; 6602312720; 17035476100; 58091357200; 59088720100; 7006013097; 7005831909; 56335935100; 57442742600; 7402560465; 56390104900 | a960112@naver.com;yejin5879@naver.com;sayseven01@naver.com;iskwun@andong.ac.kr;jhlim@andong.ac.kr;jkim3441@gatech.edu;genekim10@gmail.com;mcbaek@knu.ac.kr;mohammed.akbar@nih.gov;wonhyoseo@ewha.ac.kr;dkkim714@jbnu.ac.kr;bj.song@nih.gov;yecho@anu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 2.09 | 2025-07-30 | 32 | 33 | binge alcohol; ellagic acid; gut microbiota; intestinal barrier dysfunction; endotoxemia; inflammatory fatty liver injury | HIGH-FAT; PLANT POLYPHENOL; INDUCED TOXICITY; OXIDANT STRESS; KNOCKOUT MICE; IN-VITRO; CYP2E1; DISEASE; INFLAMMATION; ENDOTOXEMIA | Binge alcohol; Ellagic acid; Endotoxemia; Gut microbiota; Inflammatory fatty liver injury; Intestinal barrier dysfunction | English | 2021 | 2021-09 | 10.3390/antiox10091386 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Enhancement of the Antiobesity and Antioxidant Effect of Purple Sweet Potato Extracts and Enhancement of the Effects by Fermentation | The browning of white adipocytes, which transforms energy-storing white adipocytes to heat-producing beige adipocytes, is considered a strategy against metabolic diseases. Several dietary compounds, such as anthocyanins, flavonoids, and phenolic acids, induce a brown adipocyte-like phenotype in white adipocytes. In this study, we demonstrated that purple sweet potato (Ipomoea batatas) extract (PSP) exhibited potent radical scavenging activity. In addition, PSP was found to contain large amounts of phenolic, flavonoid, and anthocyanin compounds; the amount of these compounds was affected by fermentation. Functionally, PSP-induced adipose browning in high-fat-diet (HFD)-induced obese mice. The administration of PSP significantly suppressed the body weight gain and abnormal expansion of white adipose tissues in the obese mice. The expression of adipose browning-related genes was higher in the inguinal white adipose tissues from the PSP-treated mice than those in the HFD-fed mice. Moreover, PSP-treated 3T3-L1 adipocytes formed multilocular lipid droplets, similar to those formed in the 3T3-L1 adipocytes treated with a browning induction cocktail. The PSP-treated cells had an increased expression level of mitochondria and lipolysis-related genes. The browning effects of PSP were enhanced by fermentation with Lactobacillus. This study, to our knowledge, is the first to identify a new mechanism to increase the antiobesity effects of PSP by inducing adipocyte browning of adipocytes. | Lee, Seul Gi; Chae, Jongbeom; Kim, Dong Se; Lee, Jung-Bok; Kwon, Gi-Seok; Kwon, Taeg Kyu; Nam, Ju-Ock | Keimyung Univ, Sch Med, Dept Immunol, Daegu 42601, South Korea; Keimyung Univ, Ctr Forens Pharmaceut Sci, Daegu, South Korea; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyochon Res Innovat Ctr, Kyochon F&B Co Ltd, Chilgok Gun, Seoul 18469, South Korea; Andong Natl Univ, Dept Med Plant Resources, Andong 36729, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | 56995397800; 57204499421; 57220072584; 43461503000; 16947529800; 7202206057; 7201496105 | lsg100479@naver.com;chejongbum@naver.com;aodydirk@naver.com;bio91@andong.ac.kr;gskwon@andong.ac.kr;kwontk@dsmc.or.kr;namjo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 6 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 0.62 | 2025-07-30 | 10 | 11 | antiobesity; browning; fermentation; purple sweet potato; transdifferentiation | WHITE ADIPOSE-TISSUE; PPAR-GAMMA; INHIBITS ADIPOGENESIS; ASSISTED EXTRACTION; ANGIOGENIC ACTIVITY; LIPID-ACCUMULATION; 3T3-L1 ADIPOCYTES; FAT; ANTHOCYANINS; OPTIMIZATION | 3T3-L1 adipocyte; Antiobesity; Browning; Fermentation; Purple sweet potato; Transdifferentiation | English | 2021 | 2021-06 | 10.3390/antiox10060888 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Estimating the uncertainty-R&D investment relationship and its interactions with firm size | This paper investigates the uncertainty-research and development (R&D) investment relationship and its interactions with firm size by allowing flexibility in the relationships among uncertainty, R&D investment, and firm size. We hypothesize that the uncertainty effect on R&D investment varies by firm size using South Korean firm-level data. Firm-level uncertainty is measured by variation in a firm's sales revenue, and firm size is measured by two proxies: the firm's sales revenue and the firm's number of employees. We find a concave relationship between the uncertainty elasticity of R&D investment and firm size using separate models for the two firm size proxies. The concave relationship is explained by a change in the dominance of the call option effect, then the put option effect, and then again the call option effect as firm size increases. This relationship serves as an empirically informed knowledge base for policymakers to utilize in evaluating government-funded R&D contracts for encouraging R&D investment. | Cho, Seong-Hoon; Lee, Jaimin | Univ Tennessee, Dept Agr & Resource Econ, 2621 Morgan Circle,302 Morgan Hall, Knoxville, TN 37996 USA; Kyungpook Natl Univ, Sch Econ & Trade, Daehak Ro 80, Daegu 41566, South Korea | 22940061400; 56106356700 | scho9@utk.edu;jm064@knu.ac.kr; | SMALL BUSINESS ECONOMICS | SMALL BUS ECON | 0921-898X | 1573-0913 | 57 | 3 | SSCI | BUSINESS;ECONOMICS;MANAGEMENT | 2021 | 7.096 | 5.6 | 1.13 | 2025-07-30 | 14 | 16 | Firm size; Number of employees; R&D investment; Sales revenue; Uncertainty | KNOWLEDGE-INTENSITY; DYNAMIC-MODELS; IRREVERSIBILITY; GROWTH; INNOVATION; BEHAVIOR; OPTIONS; IMPACT; CITIES; LAW | Firm size; Number of employees; R&D investment; Sales revenue; Uncertainty | English | 2021 | 2021-10 | 10.1007/s11187-020-00346-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Fursultiamine Prevents Drug-Induced Ototoxicity by Reducing Accumulation of Reactive Oxygen Species in Mouse Cochlea | Drug-induced hearing loss is a major type of acquired sensorineural hearing loss. Cisplatin and aminoglycoside antibiotics have been known to cause ototoxicity, and excessive accumulation of intracellular reactive oxygen species (ROS) are suggested as the common major pathology of cisplatin- and aminoglycoside antibiotics-induced ototoxicity. Fursultiamine, also called thiamine tetrahydrofurfuryl disulfide, is a thiamine disulfide derivative that may have antioxidant effects. To evaluate whether fursultiamine can prevent cisplatin- and kanamycin-induced ototoxicity, we investigated their preventive potential using mouse cochlear explant culture system. Immunofluorescence staining of mouse cochlear hair cells showed that fursultiamine pretreatment reduced cisplatin- and kanamycin-induced damage to both inner and outer hair cells. Fursultiamine attenuated mitochondrial ROS accumulation as evidenced by MitoSOX Red staining and restored mitochondrial membrane potential in a JC-1 assay. In addition, fursultiamine pretreatment reduced active caspase-3 and TUNEL signals after cisplatin or kanamycin treatment, indicating that fursultiamine decreased apoptotic hair cell death. This study is the first to show a protective effect of fursultiamine against cisplatin- and aminoglycoside antibiotics-induced ototoxicity. Our results suggest that fursultiamine could act as an antioxidant and anti-apoptotic agent against mitochondrial oxidative stress.in cochlear hair cells. | Kim, Ye-Ri; Kwon, Tae-Jun; Kim, Un-Kyung; Lee, In-Kyu; Lee, Kyu-Yup; Baek, Jeong-In | Kyungpook Natl Univ, Coll Nat Sci, Dept Biol, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Bioresource Res Ctr, Daegu 41566, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, Lab Anim Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus Project, KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Res Inst Aging & Metab, Dept Internal Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Med, Dept Otorhinolaryngol Head & Neck Surg, Daegu 41566, South Korea; Daegu Haany Univ, Coll Herbal Bioind, Dept Aroma Appl Ind, Gyongsan 38610, South Korea | Kim, Ji-Youn/A-5779-2017; Baek, Jeong-In/AAD-2164-2019; Lee, In-Kyu/AAR-6374-2021; Lee, Doh Young/GLR-9586-2022 | 56048344100; 35798369900; 7102248968; 36071537600; 22135779500; 25651687700 | yell_90@knu.ac.kr;tjkwon@dgmif.re.kr;kimuk@knu.ac.kr;leei@knu.ac.kr;kylee@knu.ac.kr;baek@dhu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 0.46 | 2025-07-30 | 9 | 9 | cisplatin; kanamycin; ototoxicity; reactive oxygen species; fursultiamine | CISPLATIN-INDUCED OTOTOXICITY; INDUCED HEARING-LOSS; INTRATYMPANIC DEXAMETHASONE; THIAMINE; BENFOTIAMINE; PROTECTS; INHIBITION; DISULFIDE; MECHANISM; AGENTS | Cisplatin; Fursultiamine; Kanamycin; Ototoxicity; Reactive oxygen species | English | 2021 | 2021-10 | 10.3390/antiox10101526 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | High Resolution Mass Spectroscopy-Based Secondary Metabolite Profiling of Nymphaea nouchali (Burm. f) Stem Attenuates Oxidative Stress via Regulation of MAPK/Nrf2/HO-1/ROS Pathway | The secondary metabolites profiling of Nymphaea nouchali stem (NNSE) extract was carried out using a high-resolution mass spectroscopic technique. The antioxidant effects of NNSE, as well as the underlying mechanisms, were also investigated in tert-butyl hydroperoxide (t-BHP)-stimulated oxidative stress in RAW264.7 cells. Tandem mass spectroscopy with (-) negative mode tentatively revealed the presence of 54 secondary metabolites in NNSE. Among them, phenolic acids and flavonoids were predominant. Phenolic acids (brevifolincarboxylic acid, p-coumaroyltartaric acid, niazinin B, lalioside, 3-feruloylquinic acid, and gallic acid-O-rutinoside), flavonoids (elephantorrhizol, apigenin-6-C-galactoside 8-C-arabinoside, and vicenin-2), sialic acid (2-deoxy-2,3-dehydro-N-acetylneuraminic acid), and terpenoid (alpha-gamma-onoceradienedione) were identified in NNSE for the first time. Unbridled reactive oxygen species/nitrogen species (ROS/RNS) and redox imbalances participate in the induction and development of many oxidative stress-linked diseases. The NNSE exhibited significant free radical scavenging capabilities and was also able to reduce t-BHP-induced cellular generation in RAW264.7 cells. The NNSE prevented oxidative stress by inducing the endogenous antioxidant system and the levels of heme oxygenase-1 (HO-1) by upregulating Nrf2 through the modulation of mitogen-activated protein kinases (MAPK), such as phosphorylated p38 and c-Jun N terminal kinase. Collectively, these results indicate that the NNSE exhibits potent effects in preventing oxidative stress-stimulated diseases and disorders through the modulation of the MAPK/Nrf2/HO-1 signaling pathway. Our findings provide new insights into the cytoprotective effects and mechanisms of Nymphaea nouchali stem extract against oxidative stress, which may be a useful remedy for oxidative stress-induced disorders. | Alam, Md Badrul; Naznin, Marufa; Islam, Syful; Alshammari, Fanar Hamad; Choi, Hee-Jeong; Song, Bo-Rim; Kim, Sunghwan; Lee, Sang-Han | Kyungpook Natl Univ, Grad Sch, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Food & Bioind Res Inst, Inner Beauty Antiaging Ctr, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Mass Spect Converging Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea; Knu BnC, Daegu 41566, South Korea | ; Kim, Sunghwan/HKN-9812-2023; Islam, Syful/AAZ-5084-2021; Alam, Md Badrul/AFL-7668-2022; Lee, Seung Eun/ABG-1607-2021 | 56706777100; 57195955389; 57213340400; 57191860948; 57201125608; 57223138662; 57203772967; 57221453703 | mbalaml@knu.ac.kr;naznin@knu.ac.kr;syful@knu.ac.kr;alfnar@knu.ac.kr;chj1901@knu.ac.kr;sbr9707@knu.ac.kr;sungwhank@knu.ac.kr;sang@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 5 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 1.86 | 2025-07-30 | 25 | 27 | antioxidant; Dillenia indica; heme oxygenase 1 (HO-1); nuclear factor erythroid 2-related factor 2; RAW264; 7 cells | FLOWER EXTRACT; CELL-DEATH; STELLATA WILLD.; REACTIVE OXYGEN; LC-MS/MS; ANTIOXIDANT; DAMAGE; SPECTROMETRY; ACID; IDENTIFICATION | Antioxidant; Dillenia indica; Heme oxygenase 1 (HO-1); Nuclear factor erythroid 2-related factor 2; RAW264.7 cells | English | 2021 | 2021-05 | 10.3390/antiox10050719 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Identification of L-Cysteinamide as a Potent Inhibitor of Tyrosinase-Mediated Dopachrome Formation and Eumelanin Synthesis | The purpose of this study is to identify amino acid derivatives with potent anti-eumelanogenic activity. First, we compared the effects of twenty different amidated amino acids on tyrosinase (TYR)-mediated dopachrome formation in vitro and melanin content in dark-pigmented human melanoma MNT-1 cells. The results showed that only L-cysteinamide inhibited TYR-mediated dopachrome formation in vitro and reduced the melanin content of cells. Next, the antimelanogenic effect of L-cysteinamide was compared to those of other thiol compounds (L-cysteine, N-acetyl L-cysteine, glutathione, L-cysteine ethyl ester, N-acetyl L-cysteinamide, and cysteamine) and positive controls with known antimelanogenic effects (kojic acid and beta-arbutin). The results showed the unique properties of L-cysteinamide, which effectively reduces melanin content without causing cytotoxicity. L-Cysteinamide did not affect the mRNA and protein levels of TYR, tyrosinase-related protein 1, and dopachrome tautomerase in MNT-1 cells. L-Cysteinamide exhibited similar properties in normal human epidermal melanocytes (HEMs). Experiments using mushroom TYR suggest that L-cysteinamide at certain concentrations can inhibit eumelanin synthesis through a dual mechanism by inhibiting TYR-catalyzed dopaquinone synthesis and by diverting the synthesized dopaquinone to the formation of DOPA-cysteinamide conjugates rather than dopachrome. Finally, L-cysteinamide was shown to increase pheomelanin content while decreasing eumelanin and total melanin contents in MNT-1 cells. This study suggests that L-cysteinamide has an optimal structure that can effectively and safely inhibit eumelanin synthesis in MNT-1 cells and HEMs, and will be useful in controlling skin hyperpigmentation. | Lee, Hyun Kyung; Ha, Jae Won; Hwang, Yun Jeong; Boo, Yong Chool | Kyungpook Natl Univ, Sch Med, Biomed Convergence Program, Dept Mol Med,Brain Korea BK 21 Plus,Kyungpook Nat, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea | 57226324915; 57210154932; 57217489746; 6602899130 | kei01116@naver.com;jaewon1226@knu.ac.kr;hwangkyy26@naver.com;ycboo@knu.ac.kr; | ANTIOXIDANTS | ANTIOXIDANTS-BASEL | 2076-3921 | 10 | 8 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, MEDICINAL;FOOD SCIENCE & TECHNOLOGY | 2021 | 7.675 | 5.6 | 1.32 | 2025-07-30 | 18 | 19 | L-cysteinamide; tyrosinase; melanin; eumelanin; viability; MNT-1 melanoma; normal human melanocytes | DEPIGMENTING AGENT; N-ACETYLCYSTEINE; DOUBLE-BLIND; MELANOGENESIS; SKIN; GLUTATHIONE; CHEMISTRY; CELLS; PIGMENTATION; CYSTEAMINE | Eumelanin; L-cysteinamide; Melanin; MNT-1 melanoma; Normal human melanocytes; Tyrosinase; Viability | English | 2021 | 2021-08 | 10.3390/antiox10081202 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Integrated multi-omics analysis reveals the underlying molecular mechanism for developmental neurotoxicity of perfluorooctanesulfonic acid in zebrafish | Limited studies on multi-omics have been conducted to comprehensively investigate the molecular mechanism underlying the developmental neurotoxicity of perfluorooctanesulfonic acid (PFOS). In this study, the locomotor behavior of zebrafish larvae was assessed under the exposure to 0.1-20 mu M PFOS based on its reported neurobehavioral effect. After the number of zebrafish larvae was optimized for proteomics and metabolomics studies, three kinds of omics (i.e., transcriptomics, proteomics, and metabolomics) were carried out with zebrafish larvae exposed to 0.1, 1, 5, and 10 mu M PFOS. More importantly, a data-driven integration of multi-omics was performed to elucidate the toxicity mechanism involved in developmental neurotoxicity. In a concentration-dependent manner, exposure to PFOS provoked hyperactivity and hypoactivity under light and dark conditions, respectively. Individual omics revealed that PFOS exposure caused perturbations in the pathways of neurological function, oxidative stress, and energy metabolism. Integrated omics implied that there were decisive pathways for axonal deformation, neuroinflammatory stimulation, and dysregulation of calcium ion signaling, which are more clearly specified for neurotoxicity. Overall, our findings broaden the molecular understanding of the developmental neurotoxicity of PFOS, for which multi-omics and integrated omics analyses are efficient for discovering the significant molecular pathways related to developmental neurotoxicity in zebrafish. | Lee, Hyojin; Sung, Eun Ji; Seo, Seungwoo; Min, Eun Ki; Lee, Ji-Young; Shim, Ilseob; Kim, Pilje; Kim, Tae-Young; Lee, Sangkyu; Kim, Ki-Tae | Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea; Kyungpook Natl Univ, BK21 FOUR Community Based Intelligent Novel Drug, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Gwangju Inst Sci & Technol, Sch Earth Sci & Environm Engn, Gwangju 61005, South Korea; Natl Inst Environm Res, Environm Hlth Res Dept, Incheon 22689, South Korea | ; KIM, KI-TAE/AAX-3175-2020; Shim, Ilseob/AAE-1919-2019 | 57200522840; 56988948200; 57201981362; 57221692953; 57269014600; 55355656300; 55272896600; 57049826900; 57209046767; 57202074566 | kimtaeyoung@gist.ac.kr;sangkyu@knu.ac.kr;ktkim@seoultech.ac.kr; | ENVIRONMENT INTERNATIONAL | ENVIRON INT | 0160-4120 | 1873-6750 | 157 | SCIE | ENVIRONMENTAL SCIENCES | 2021 | 13.352 | 5.6 | 2.94 | 2025-07-30 | 62 | 62 | Perfluorooctanesulfonic acid; Neurotoxicity; Multi-omics; Integration; Zebrafish | NEONATAL EXPOSURE; PFOS; SULFONATE; EXPRESSION; BEHAVIOR; HEALTH | Integration; Multi-omics; Neurotoxicity; Perfluorooctanesulfonic acid; Zebrafish | Alkanesulfonic Acids; Animals; Embryo, Nonmammalian; Fluorocarbons; Larva; Water Pollutants, Chemical; Zebrafish; Danio rerio; Metabolism; Molecular biology; alkanesulfonic acid; fluorocarbon; perfluorooctanesulfonic acid; 'omics'; Developmental neurotoxicity; Locomotor behavior; Molecular mechanism; Multi-omic; Neurobehavioural; Neurotoxicity; Perfluorooctanesulphonic acid; Zebrafish; Zebrafish larvae; concentration (composition); experimental study; molecular analysis; neurology; percid; physiological response; toxicity; animal; larva; nonmammalian embryo; toxicity; water pollutant; zebra fish; Integration | English | 2021 | 2021-12 | 10.1016/j.envint.2021.106802 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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