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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Comparable outcomes for pediatric acute lymphoblastic leukemia patients receiving conditioning with total body irradiation or chemotherapy: A nationwide, Korean registry-based study ⓘ Acute lymphoblastic leukemia (ALL) is the predominant malignancy in pediatric patients, and allogeneic hematopoietic stem cell transplantation (HSCT) plays a critical role in high-risk cases. However, real-world nationwide data comparing the outcomes of conditioning regimens are limited. This nationwide registry-based study analyzed data from 270 Korean pediatric patients with high-risk or relapsed ALL who underwent their first allogeneic HSCT with myeloablative conditioning. Among all analyzed patients, 118 received total body irradiation-based conditioning (MAC-TBI) and 152 received chemotherapy-based conditioning (MAC-Chemotherapy), of whom 96.6% underwent busulfan-based regimens. MAC-TBI recipients were older at diagnosis and at HSCT. No significant differences were observed between groups in neutrophil or platelet engraftment times, or infused CD34+ cell doses. Acute graft-versus-host disease (GVHD) incidences (grades II-IV and III-IV) were comparable, although chronic GVHD incidence tended to be lower in the MAC-Chemotherapy group (21.0% vs. 31.1%, P = 0.072). Additionally, the 5-year event-free survival (EFS) rates for MAC-TBI versus MAC-Chemotherapy were 73.7% and 69.8% (P = 0.827), respectively; the 5-year overall survival (OS) rates were 76.3% and 80.2% (P = 0.941), respectively, indicating that conditioning regimen did not significantly impact survival. Pediatric disease risk index, recent HSCT era, haploidentical donor type, and pre-transplant disease status independently influenced EFS and OS, whereas anti-thymocyte globulin administration significantly improved moderate-to-severe chronic GVHD, leukemia-free survival. This nationwide real-world analysis demonstrated comparable outcomes between myeloablative TBI-based and chemotherapy-based conditioning regimens in pediatric patients with ALL. These findings may inform the development of improved treatment strategies for this patient population. ⓘ Hong, Kyung Taek; Choi, Jung Yoon; Kim, Hyery; Im, Ho Joon; Hahn, Seung Min; Lyu, Chuhl Joo; Ju, Hee Young; Yoo, Keon Hee; Yang, Eu Jeen; Yoon, Sung-Soo; Park, Hyeon Jin; Choi, Hyoung Soo; Chueh, Hee Won; Yang, Deok-Hwan; Moon, Joon Ho; Lee, Jae Min; Lee, Jung-Hee; Kim, Jeong-A; Won, Jong-Ho; Kang, Hyoung Jin ⓘ Seoul Natl Univ, Coll Med, Childrens Hosp, Canc Res Inst,Dept Pediat, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Pediat, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Pediat Hematol Oncol, Yonsei Canc Ctr, Seoul, South Korea; Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Pediat, Seoul, South Korea; Pusan Natl Univ, Childrens Hosp, Dept Pediat, Pusan, South Korea; Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Internal Med,Div Hematol & Med Oncol,Canc Res, Seoul 110744, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Ctr Pediat Canc, Dept Publ Hlth & AI, Goyang, South Korea; Seoul Natl Univ, Coll Med, Dept Pediat, Bundang Hosp, Seongnam, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Pediat, Pusan, South Korea; Chonnam Natl Univ, Hwasun Hosp, Dept Hematol Oncol, Med Sch, Hwasun, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Hematol Oncol, Daegu, South Korea; Yeungnam Univ, Coll Med, Dept Pediat, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Hematol, Seoul, South Korea; Catholic Univ Korea, St Vincent Hosp, Coll Med, Dept Internal Med,Div Hematol, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Div Hematol Oncol,Seoul Hosp, Seoul, South Korea; Wide River Inst Immunol, Hongcheon, South Korea ⓘ ⓘ 55145561500; 57102078500; 57196215369; 57981670900; 56645629700; 7004643628; 59660079600; 35304229600; 56594276100; 59653630900; 59692744300; 59935770600; 39261421100; 59540614100; 59091938000; 59947346700; 57196140713; 57204030179; 59946248600; 7404071502 ⓘ kanghj@snu.ac.kr; ⓘ HEMASPHERE ⓘ HEMASPHERE ⓘ 2572-9241 9 6 SCIE HEMATOLOGY ⓘ 2024 14.6 4.6 N/A ⓘ 0 0 ⓘ STEM-CELL TRANSPLANTATION; RESIDUAL DISEASE; CHILDREN; CHILDHOOD; BUSULFAN; FAILURE ⓘ ⓘ busulfan; CD34 antigen; cyclophosphamide; cyclosporine; cytarabine; etoposide; fludarabine; melphalan; mycophenolate mofetil; tacrolimus; thiotepa; thymocyte antibody; treosulfan; acute graft versus host disease; adolescent; allogeneic hematopoietic stem cell transplantation; Article; cancer patient; cancer prognosis; cancer specific survival; child; childhood acute lymphoblastic leukemia; chronic graft versus host disease; cohort analysis; conditioning chemotherapy; controlled study; cumulative incidence; cytomegalovirus infection; event free survival; eye disease; female; gastrointestinal disease; graft recipient; graft versus host reaction; haploidentical donor; hemorrhagic cystitis; human; leukemia relapse; liver disease; lung disease; major clinical study; male; mouth disease; myeloablative conditioning; neutrophil; overall survival; patient registry; posttransplant lymphoproliferative disease; retrospective study; skin disease; South Korea; survival rate; thrombocyte; time; whole body radiation ⓘ English 2025 2025-06 10.1002/hem3.70158 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Enhancing dental education with a 3D point cloud comparison and augmented reality for auto-evaluation of fixed prosthodontic practice: An in vitro study ⓘ Objectives: Traditional fixed prosthodontic training evaluations are time-consuming and subjective. This study aimed to introduce and evaluate a novel 3D auto-evaluate tooth preparation with an augmented reality (3DAR) visualization algorithm to enhance dental education for students and improve the efficiency of fixed prosthodontic training evaluations. Methods: Fifty maxillary central incisors and first molars prepared by 50 dental students on typodont models were scanned with a 3D scanner to capture STL files and evaluated using the 3DAR algorithm, which calculated Euclidean distances and root mean square error (RMSE) for accuracy assessment and assigned scores based on RMSE, using an augmented reality (AR) app for interactive evaluation and visualization. These scores were compared to manual scoring with computer assistance (MSCA method), which also used RMSE but required manual alignment and model scoring. Intrarater and interrater reliability of the 3DAR scoring method was assessed using intraclass correlation coefficients (ICC) and compared with the MSCA method. Additionally, the feasibility of 3DAR was evaluated based on evaluation time and user satisfaction. Results: The 3DAR method demonstrated good-to-excellent interrater agreement (ICC = 0.75-0.95) and perfect intrarater reliability (ICC = 1), while the MSCA method showed moderate-to-good reliability (ICC = 0.74-0.89). 3DAR significantly reduced evaluation time (10.514 s vs. 2 h required for MSCA) and received high user satisfaction ratings (average score = 4.66 +/- 0.24). Conclusions: The 3DAR algorithm offers a reliable and efficient assessment method for prosthodontic training. It showed strong agreement with traditional methods, significantly reduced evaluation time, and achieved high user satisfaction. Clinical significance: The integration of a 3D augmented reality-based auto-evaluation algorithm into tooth preparation training enhances reliability and provides interactive, real-time feedback on performance, highlighting its potential to advance dental education practices. ⓘ Mai, Hang-Nga; Kim, Yong-Gun; Cho, Seok-Hwan; Joda, Tim; Lee, Du-Hyeong ⓘ Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea; Hanoi Univ Business & Technol, Dent Sch, Hanoi, Vietnam; Kyungpook Natl Univ, Sch Dent, Dept Periodontol, Daegu, South Korea; Univ Iowa, Coll Dent & Dent Clin, Dept Prosthodont, Iowa City, IA 52242 USA; Univ Zurich, Ctr Dent Med, Clin Reconstruct Dent, Zurich, Switzerland; Kyungpook Natl Univ, Sch Dent, Dept Prosthodont, Daegu, South Korea ⓘ Mai, Hang-Nga/Q-9865-2018; Kim, Yong-Gun/JPQ-3309-2023 ⓘ 56964780900; 55622694400; 12780626400; 55313227300; 35770948000 ⓘ dewey-lee@uiowa.edu; ⓘ JOURNAL OF DENTISTRY ⓘ J DENT ⓘ 0300-5712 1879-176X 153 SCIE DENTISTRY, ORAL SURGERY & MEDICINE ⓘ 2024 5.5 4.6 0 2025-05-07 ⓘ 0 0 Augmented reality; Tooth preparation; Automated scoring; Preclinical practice; Reliability; Feasibility; Dental education ⓘ VIRTUAL-REALITY; TOOTH PREPARATION; SOFTWARE ⓘ Augmented reality; Automated scoring; Dental education; Feasibility; Preclinical practice; Reliability; Tooth preparation ⓘ Algorithms; Augmented Reality; Cloud Computing; Education, Dental; Humans; Imaging, Three-Dimensional; Incisor; Models, Dental; Molar; Prosthodontics; Reproducibility of Results; Students, Dental; algorithm; augmented reality; cloud computing; comparative study; dental education; dental model; dental student; education; human; incisor; molar tooth; procedures; prosthodontics; reproducibility; three-dimensional imaging ⓘ English 2025 2025-02 10.1016/j.jdent.2024.105493 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Identification of YAP regulators through high-throughput screening and NanoBiT-based validation-drug repositioning for cancer therapy ⓘ Yes-associated protein (YAP), a key co-transcription factor of the Hippo pathway, is a promising drug target for cancer therapy due to its critical role in promoting cell proliferation, survival, and tumor progression when dysregulated. While most Hippo pathway-targeting drugs focus on disrupting TEAD-YAP interactions or modulating the MST or LATS kinase cascade, new approaches are needed to identify small molecules that regulate YAP activity. In this study, we conducted high-throughput screening of FDA-approved drugs to discover potential YAP modulators. Using a NanoBiT-based system, which enables real-time and quantitative measurement of protein interactions, combined with phenotype-based assays in EGFP-YAP-expressing cells, we identified compounds that activate or inhibit YAP function. Among the identified YAP regulators, the microtubule destabilizer vinorelbine promoted YAP nuclear localization and transcriptional activation, while the antipsychotic drug thioridazine enhanced YAP phosphorylation at Ser127, resulting in its cytoplasmic retention and reduced transcriptional activity, effectively suppressing cancer cell growth. These findings demonstrate the potential of FDA-approved drugs in modulating YAP activity and present a novel screening strategy for developing YAP-targeting therapeutics. Furthermore, this approach can be extended to identify modulators of other signaling pathways, advancing drug discovery for a wide range of diseases. ⓘ Lim, Ji-Youn; Choi, Eui-Hwan; Kim, Yujeong; Kim, Minseong; Choi, Dongkyu; Kim, Wantae; Cha, Boksik ⓘ Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Univ Seoul, Dept Life Sci, Seoul 02504, South Korea; Hannam Univ, Dept Biopharmaceut Engn, Daejeon, South Korea; Kyungpook Natl Univ, KNU G LAMP Project Grp, KNU Inst Basic Sci, Sch Life Sci & Biotechnol,FOUR KNU Creat BioRes Gr, Daegu, South Korea; Chungnam Natl Univ, Dept Biochem, Daejeon, South Korea ⓘ ⓘ 59502308500; 59781896000; 59501912200; 59781896100; 57215816624; 55492085700; 36899852200 ⓘ wantaekim@uos.ac.kr; boksik-cha@kmedihub.re.kr; ⓘ ANIMAL CELLS AND SYSTEMS ⓘ ANIM CELLS SYST ⓘ 1976-8354 2151-2485 29 1 SCIE CELL BIOLOGY;ZOOLOGY ⓘ 2024 3.2 4.7 N/A ⓘ 0 0 YAP; NanoBiT; thioridazine; vinorelbine; high-throughput screening ⓘ HIPPO PATHWAY; YAP/TAZ; MECHANISM; TARGETS; PROTEIN; TEAD ⓘ high-throughput screening; NanoBiT; thioridazine; vinorelbine; YAP ⓘ ⓘ English 2025 2025-12-31 10.1080/19768354.2025.2489389 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Orchestrated interfacial reprogramming via Al-F-C synergy for dynamic CEI structuring in advanced cathodes ⓘ Achieving robust interfacial stability under high-rate operation remains a grand challenge for commercial lithium-ion batteries, particularly in cathodes subjected to extreme cycling conditions. Herein, we propose an orchestrated interfacial reprogramming strategy that integrates Al3+/F-co-doping and conformal carbon coating to direct the formation of a self-aligned, LiF-rich cathode-electrolyte interphase (CEI). Unlike conventional CEI regulation strategies based on single-element doping or inert surface coatings, this multi-component approach enables an actively constructed, crystallographically aligned CEI through the synergistic interplay of dopants and carbon. This approach enables dynamic CEI structuring that minimizes interfacial resistance and enhances lithium-ion transport kinetics. As a proof of concept, LiFePO4 (LFP) was employed as a model system, delivering an ultrafast discharge capacity of 146.6 mAh g-1 at 10C and exceptional longevity with 2931 cycles at 1C and 100 % Coulombic efficiency. XPS and in situ XRD analyses confirmed the preferential orientation of the LiF-rich CEI, linked to the improved electrochemical performance. To validate the platform independence of this approach, the same interfacial framework was extended to layered NCM613 cathodes, which exhibited significant performance enhancement despite the absence of detectable crystalline LiF signals-likely due to the formation of a thinner, more uniform CEI layer. This work establishes a universal and actively tunable CEI engineering paradigm that transcends traditional passive approaches, offering a transformative pathway toward high-power, long-life lithium-ion batteries. ⓘ Moon, Hojun; Jeong, Harim; Shin, Hyunsub; Lee, Jaehun; Im, Younghwan; Do, Jeong Yeon; Kwak, Byeong Sub; Son, Namgyu; Yoo, Jeeyoung; Kang, Misook ⓘ Yeungnam Univ, Coll Nat Sci, Dept Chem, Gyongsan 38541, South Korea; Korea Res Inst Chem Technol KRICT, 141 Gajeong Ro, Daejeon 34114, South Korea; Korea Evaluat Inst Ind Technol KEIT, Cheomdan Ro 8 Gil, Daegu 41069, South Korea; Korea Elect Power Res Inst KEPRI 105 Munji ro, Daejeon 34056, South Korea; Res Inst Ind Sci & Technol RIST, Particulate Matter Res Ctr, 187-12 Geumho Ro, Gwangyang si 57801, Jeollanam do, South Korea; Kyungpook Natl Univ, Sch Energy Engn, 80 Daehak ro, Daegu 41566, South Korea ⓘ ⓘ 57792240400; 24332221700; 58865438100; 56797771500; 55880054200; 56603769000; 35102527600; 57194434491; 56046607500; 35201139000 ⓘ jyoo@knu.ac.kr; mskang@ynu.ac.kr; ⓘ ENERGY STORAGE MATERIALS ⓘ ENERGY STORAGE MATER ⓘ 2405-8297 2405-8289 80 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY ⓘ 2024 20.2 4.7 N/A ⓘ 0 0 Interfacial reprogramming; LiF-rich CEI; Al-F-C synergy; Dynamic CEI structuring; Platform-independent cathodes ⓘ LIFEPO4; BEHAVIOR ⓘ Al–F–C synergy; Dynamic CEI structuring; Interfacial reprogramming; LiF-rich CEI; Platform-independent cathodes ⓘ Aluminum coatings; Semiconductor doping; Al–F–C synergy; Dynamic cathode–electrolyte interphase structuring; High rate; Interfacial reprogramming; Interfacial stabilities; Ion batteries; LiF-rich cathode–electrolyte interphase; Lithium ions; Platform independent; Platform-independent cathode; Lithium-ion batteries ⓘ English 2025 2025-07 10.1016/j.ensm.2025.104384 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Pregnenolone sulfate potentiates tetrodotoxin-resistant Na⁺ channels to increase the excitability of dural afferent neurons in rats ⓘ BackgroundAlthough peripheral administration of pregnenolone sulfate (PS) has been reported to produce pronociceptive effects, the mechanisms by which PS modulates the excitability of nociceptive neurons are poorly understood. Here, we report on the excitatory role of PS in peripheral nociceptive neurons, focusing on its effects on tetrodotoxin-resistant (TTX-R) Na+ channels.MethodsTTX-R Na+ current (INa) mediated by NaV1.8 was recorded from acutely isolated small-sized dural afferent neurons of rats, identified with the retrograde fluorescent dye DiI, using a whole-cell patch-clamp technique.ResultsTranscripts for enzymes and transporters involved in PS biosynthesis were detected in the ophthalmic branch of the trigeminal ganglia. In voltage-clamp mode, PS preferentially potentiated the TTX-R persistent INa, a small non-inactivating current during sustained depolarization. PS shifted the voltage-inactivation relationship toward a depolarizing range. PS also delayed the onset of inactivation and accelerated the recovery from inactivation of TTX-R Na+ channels. Additionally, PS decreased the extent of use-dependent inhibition of TTX-R Na+ channels. In current-clamp mode, PS hyperpolarized dural afferent neurons by increasing the leak K+ conductance. Nevertheless, PS decreased the rheobase current-the minimum current required to generate action potentials-and increased the number of action potentials elicited by depolarizing current stimuli.ConclusionWe have shown that the excitatory neurosteroid PS preferentially potentiates TTX-R persistent INa and reduces the inactivation of TTX-R Na+ channels, resulting in increased excitability of dural afferent neurons. The potential role of endogenous PS in migraine pathology warrants further investigation. ⓘ Jang, Il-Sung; Nakamura, Michiko ⓘ Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, 2177 Dalgubeol Daero, Daegu 41940, South Korea ⓘ ⓘ 7102177910; 36051866000 ⓘ jis7619@knu.ac.kr; michiko21a@gmail.com; ⓘ JOURNAL OF HEADACHE AND PAIN ⓘ J HEADACHE PAIN ⓘ 1129-2369 1129-2377 26 1 SCIE CLINICAL NEUROLOGY;NEUROSCIENCES ⓘ 2024 7.9 4.7 0 2025-05-07 ⓘ 0 0 ⓘ GATED SODIUM-CHANNELS; SPONTANEOUS GLUTAMATE RELEASE; NEUROSTEROID PREGNENOLONE; POTASSIUM CHANNELS; MODULATION; EXPRESSION; RECEPTORS; STEROIDS; BRAIN; PAIN ⓘ ⓘ Animals; Dura Mater; Male; Neurons, Afferent; Patch-Clamp Techniques; Pregnenolone; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Trigeminal Ganglion; capsaicin; fluorescent dye; ketamine; n (2,4 difluorobenzyl) 2' [[[(4 methoxyphenyl)acetyl]amino]methyl]biphenyl 2 carboxamide; n [2 (3,4 dichlorophenyl)ethyl] 2 dimethylamino n methylethylamine; neurosteroid; pregnenolone sulfate; riluzole; sodium channel; tetrodotoxin; pregnenolone; pregnenolone sulfate; sodium channel; sodium channel blocking agent; tetrodotoxin; action potential; afterhyperpolarization; animal experiment; animal tissue; aqueous solution; Article; biosynthesis; brain region; cell membrane; concentration response; conductance; controlled study; current amplitude; current clamp technique; decay time constant; depolarization; disease duration; drug effect; drug structure; drug synthesis; excitability; ganglion; hippocampal tissue; IC50; membrane current; membrane depolarization; membrane steady potential; migraine; nerve cell excitability; nociception; nonhuman; patch clamp technique; rat; sensory nerve cell; slope factor; steady state; steroidogenesis; voltage clamp technique; whole cell patch clamp; animal; dura mater; male; metabolism; physiology; Sprague Dawley rat; trigeminus ganglion ⓘ English 2025 2025-02-25 10.1186/s10194-025-01968-7 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ RA-PR058, a novel ramalin derivative, reduces BACE1 expression and phosphorylation of tau in Alzheimer's disease mouse models ⓘ Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by cognitive decline, anxiety-like behavior, beta-amyloid (A beta) accumulation, and tau hyperphosphorylation. BACE1, the enzyme critical for A beta production, has been a major therapeutic target; however, direct BACE1 inhibition has been associated with adverse side effects. This study investigates the therapeutic potential of RA-PR058, a novel ramalin derivative, as a multi-targeted modulator of AD-related pathologies. The effects of RA-PR058 were evaluated in vitro and in vivo. In vitro studies used SH-SY5Y cells under oxidative stress conditions to assess BACE1 expression, while in vivo effects were studied in 3xTg-AD mice following one month of oral RA-PR058 treatment. Behavioral assessments, biochemical analyses, transcriptomic profiling, and pharmacokinetic evaluations were performed to determine the efficacy of RA-PR058. RA-PR058 significantly reduced oxidative stress-induced BACE1 expression in vitro and decreased cortical BACE1 expression in 3xTg-AD mice. In vivo treatment alleviated anxiety-like behavior and reduced tau phosphorylation at disease-relevant sites (Ser202/Thr205, Thr231, and Ser396). Transcriptomic analysis revealed RA-PR058-mediated gene expression changes related to central nervous system development, response to hypoxia, and neuroactive ligand-receptor interactions, suggesting broader regulatory effects on AD-related pathways. Pharmacokinetic analysis demonstrated that RA-PR058 exhibits high metabolic stability, minimal cytochrome P450 interactions, and moderate blood-brain barrier penetration. RA-PR058 demonstrates potential as a multi-target AD therapeutic by reducing BACE1 expression, tau hyperphosphorylation, and anxiety-like behavior, coupled with favorable pharmacokinetics. Additional studies are needed to assess cognitive effects and clarify molecular mechanisms, but RA-PR058 may represent a promising advancement in addressing AD's complex pathology. ⓘ Cho, Yongeun; Lee, Jeongmi; Kim, Jun-Sik; Jeon, Yeji; Han, Sukmin; Cho, Heewon; Lee, Yeongyeong; Kim, Tai Kyoung; Hong, Ju-Mi; Lee, Yujeong; Byun, Yujung; Chae, Minshik; Park, Sunyoung; Palomera, Leon F.; Park, Sang Yoon; Kim, Hyunwook; Kim, Soyeong; Kang, Seongeun; Jee, Jun-Goo; An, Hongchan; Yim, Joung Han; Kim, Sung Hyun; Jo, Dong-Gyu ⓘ Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Kyung Hee Univ, Grad Sch, Dept Neurosci, Seoul 02447, South Korea; Korea Polar Res Inst, Incheon 21990, South Korea; Ahngook Pharmaceut, Bio Res Dept, Gwacheon, South Korea; Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea; CHA Univ, Coll Pharm, Pochon, South Korea; CHA Univ, Inst Pharmaceut Sci, Pochon, South Korea; Kyung Hee Univ, Sch Med, Dept Physiol, Seoul 02447, South Korea; Sungkyunkwan Univ, Biomed Inst Convergence, Suwon 16419, South Korea; Sungkyunkwan Univ, Samsung Adv Inst Hlth Sci & Technol, Seoul, South Korea; Sungkyunkwan Univ, Inst Quantum Biophys, Suwon, South Korea ⓘ Jo, Dong-Gyu/AAN-9278-2021 ⓘ 57223846042; 22135752800; 57221731791; 58938388400; 57217866854; 59792144100; 57673101000; 55873010200; 55874181100; 57192009673; 59550538500; 59254841400; 57191670869; 57256729100; 59549586000; 59549851100; 59549851200; 59549993000; 7004327823; 59549993100; 7101736282; 57030715600; 7006823770 ⓘ jhyim@kopri.re.kr; sunghyunkim@khu.ac.kr; jodg@skku.edu; ⓘ ANIMAL CELLS AND SYSTEMS ⓘ ANIM CELLS SYST ⓘ 1976-8354 2151-2485 29 1 SCIE CELL BIOLOGY;ZOOLOGY ⓘ 2024 3.2 4.7 0 2025-05-07 ⓘ 0 0 Alzheimer's disease; BACE1; Tau; RA-PR058 ⓘ BETA-SECRETASE; PROTEIN; INHIBITION; ASSAY ⓘ Alzheimer’s disease; BACE1; RA-PR058; Tau ⓘ ⓘ English 2025 2025-12-31 10.1080/19768354.2025.2459649 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Thermal-electrical-linked analysis of a thermal battery powering a guided weapon system ⓘ Thermal management of a thermal battery is critical to ensure the robust operation of guided weapon systems. The electrical performance of the thermal battery is highly sensitive to changes in battery temperature during operation; the battery resistance increases significantly at low temperatures and the discharge capacity can be significantly reduced at excessively high temperatures. However, the thermal management and electrical performance of thermal batteries have been studied independently without linking them. In this study, a thermal- electrical-linked analysis platform was developed to predict the internal temperature variation and the resulting voltage variation of a thermal battery. The parameters of the Thevenin equivalent circuit model (TECM) as a function of temperature, depth of discharge (DoD), and applied current were obtained from a discharge test conducted on a unit cell. The temperature changes of the electrodes and electrolyte in unit cells were traced during activation and discharge. Based on the simulation temperatures, the thermal stability of the battery was analyzed considering the melting point of each component, and subsequently, the time required for activation and reaching the cut-off voltage was evaluated according to the operating temperature and discharge rate. ⓘ Kim, Jin Beom; Bae, Eun Hye; Kim, Hyun Jun; Lee, Sang Jin; Park, Il Seouk; Kim, Sung Yeol ⓘ Kyungpook Natl Univ, Dept & Sch Mech Engn, 80 Daehakro Bukgu, Daegu 41566, South Korea; Vitzromiltech, 58 Pungsesandan Ro, Cheonan 31214, South Korea ⓘ Kim, Hayun/F-8208-2018; LEE, Sang/Q-9969-2019 ⓘ 58504809700; 59538528200; 58023747900; 57340001000; 50262800000; 19337822900 ⓘ einstein@knu.ac.kr; sykimknu@knu.ac.kr; ⓘ APPLIED THERMAL ENGINEERING ⓘ APPL THERM ENG ⓘ 1359-4311 1873-5606 267 SCIE ENERGY & FUELS;ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS ⓘ 2024 6.9 4.7 2.67 2025-05-07 ⓘ 1 1 Thermal battery; Equivalent circuit model; Performance estimation; Thermal design; Molten salt electrolyte ⓘ PHASE-CHANGE; HEAT-TRANSFER; CONVECTION; ANODE ⓘ Equivalent circuit model; Molten salt electrolyte; Performance estimation; Thermal battery; Thermal design ⓘ Thermal modeling; Electrical performance; Equivalent circuit model; Guided weapon systems; Molten salt electrolytes; Performance estimation; Robust operation; Thermal; Thermal batteries; Thermal designs; Unit cells; Critical temperature ⓘ English 2025 2025-05-15 10.1016/j.applthermaleng.2025.125737 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Zeolitic imidazolate framework-derived bifunctional CoO-Mn3O4 heterostructure cathode enhancing oxygen reduction/evolution via dynamic O-vacancy formation and healing for high-performance Zn-air batteries ⓘ Zn-air batteries (ZABs) are promising electrochemical energy storages for many applications, yet their performance is limited by their cathode's poor activity and reversibility for oxygen evolution reaction (OER) in charge and oxygen reduction reaction (ORR) in discharge. Herein, we report a bifunctional CoO-Mn3O4 heterostructure (CMH) cathode synthesized from an Mn-doped zeolitic imidazolate framework as a solution to these challenges. Combined machine learning-augmented density functional theory simulations and operando differential electrochemical mass spectrometry with 18 O isotope labeling reveal dynamic O-vacancy (Ov) formation through OH- desorption from Mn sites during ORR or bidentate oxygen adsorption at Mn-Mn sites during OER, with dynamic Ov healing through OH- adsorption and deprotonation. This dynamic process lowers O* binding energy to activate the lattice oxidation mechanism for efficient OER/ORR, exhibited by record-low overpotential and stable operation over 2000 cycles for OER and a diffusion-limited current density of 7.1 mA & sdot;cm-2 surpassing Pt/C (5.0 mA cm-2 ) for ORR. Moreover, the ZAB with the CMH cathode benefits from an ideal open-circuit voltage (1.43 V) and a high capacity of 802 mAh & sdot;g-1 (97.8 % of theoretical), to achieve its record-high energy density (898 Wh & sdot;kg-1), ultrahigh peak-power density (394.2 mW & sdot;cm-2), and stability with negligible voltage degradation over 600 cycles. ⓘ Choi, Jong Hui; Chun, Hoje; Kim, Dong Won; Kabiraz, Mrinal Kanti; Kim, Jeonghyeon; Kim, Jihoon; Kim, Keon-Han; Wang, Benzhi; Jeong, Hyung Mo; Choi, Sang-Il; Han, Byungchan; Kang, Jeung Ku ⓘ Korea Adv Inst Sci & Technol KAIST, Dept Mat Sci & Engn, 291 Daehak Ro, Daejeon 34141, South Korea; Yonsei Univ, Dept Chem & Biomol Engn, 50 Yonsei Ro, Seoul 03722, South Korea; MIT, Dept Mat Sci & Engn, 182 Mem Dr, Cambridge, MA 02139 USA; Kyungpook Natl Univ, Dept Chem, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehak Ro, Daegu 41566, South Korea; Lawrence Berkeley Natl Lab, Chem Sci Div, 1 Cyclotron Rd, Berkeley, CA 94720 USA; Sungkyunkwan Univ, Sch Mech Engn, 2066 Seobu Ro, Suwon 16419, South Korea; Sungkyunkwan Univ, Dept Smart Fab Technol, 2066 Seobu Ro, Suwon 16419, South Korea ⓘ Kabiraz, Mrinal/AAE-6381-2020; Choi, Sangil/N-7571-2013; Han, Byungchan/G-2615-2018; Benzhi, Wang/AGZ-2552-2022 ⓘ 57192394193; 57195466596; 36066372400; 57201400780; 57194560892; 57221537445; 57191910450; 57205606723; 42061388000; 56167600800; 10639592000; 7404516956 ⓘ hmjeong@skku.edu; sichoi@knu.ac.kr; bchan@yonsei.ac.kr; jeung@kaist.ac.kr; ⓘ ENERGY STORAGE MATERIALS ⓘ ENERGY STORAGE MATER ⓘ 2405-8297 2405-8289 75 SCIE CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY ⓘ 2024 20.2 4.7 0 2025-05-07 ⓘ 0 1 Bifunctional heterostructure cathode; Dynamic O -vacancy formation and healing; Oxygen reduction/evolution reaction; Machine learning and operand o; characterizations; High performance Zn-air batteries ⓘ ⓘ Bifunctional heterostructure cathode; Dynamic O-vacancy formation and healing; High performance Zn-air batteries; Machine learning and operando characterizations; Oxygen reduction/evolution reaction ⓘ Electrolytic reduction; Manganese oxide; Oxygen cutting; Oxygen evolution reaction; Oxygen reduction reaction; Photodissociation; Photoionization; Rate constants; Zinc air batteries; Zinc alloys; Zinc sulfide; Bi-functional; Bifunctional heterostructure cathode; Dynamic O-vacancy formation and healing; Evolution reactions; High performance zn-air battery; Machine learning and operando characterization; Machine-learning; O vacancies; Operando; Oxygen reduction/evolution; Oxygen reduction/evolution reaction; Performance; Vacancy formation; Cathodes ⓘ English 2025 2025-02 10.1016/j.ensm.2025.104040 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Polysulfone-reinforced quorum quenching media with silica cage encapsulation: Advancing biofouling control in anaerobic membrane bioreactors ⓘ Microbial quorum quenching (QQ) using live QQ cells entrapped in a hydrophilic polymer network (e.g., hydrogel) reduces membrane biofouling but encounters challenges regarding mechanical robustness and longterm stability. This study addresses this limitation by developing a novel composite biomedium that encapsulates QQ cells (Rhodococcus sp. BH4) within porous silica cages, which act as a protective barrier against solvent exposure, and further reinforces the structure with polysulfone, a thermally and chemically stable polymer. Surface observations confirmed the successful encapsulation of the cells within the silica matrices. Further analyses revealed the distinct nature of the composite media composed of QQ bacteria, silica, and polymer networks with an amorphous structure essential for flexibility and cell viability. The mechanical properties of the polysulfone-reinforced biomedia were significantly improved, with tensile strength nearly four times higher than that of the conventional hydrogel-based biomedia, making the new media far more durable for long-term applications. When exposed directly to the solvent dimethylacetamide, unprotected BH4 cells experienced severe death and inactivation; however, encapsulation in the porous silica cages maintained 70% cell viability and 77% QQ activity, demonstrating the protective efficacy of the silica matrix. In anaerobic membrane bioreactor applications, the reinforced QQ media showed remarkable biofouling mitigation, extending operational times by approximately threefold and twofold compared to reactors with no media and vacant media, respectively. Using composite QQ media led to significant reductions in the concentrations of biopolymers and quorum-sensing signal molecules, contributing to prolonged membrane service times without negatively impacting overall treatment performance. These findings represent a significant advancement in developing QQ media for antifouling, sustaining the functionality of live QQ cells within durable polymer matrices. ⓘ Shah, Syed Salman Ali; Kim, Jinwoo; Park, Hyeona; Mameda, Naresh; Lee, Kibaek; Ng, How Yong; Choo, Kwang-Ho ⓘ Beijing Normal Univ Zhuhai, Adv Inst Nat Sci, Ctr Water Res, Zhuhai 519087, Peoples R China; Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Adv Inst Water Ind, 80 Daehak Ro, Daegu 41566, South Korea; Koneru Lakshmaiah Educ Fdn, Dept Chem, Collage Engn, Vaddeswaram 522302, Andhra Pradesh, India; Chonnam Natl Univ, Dept Biotechnol & Bioengn, 77 Yongbong Ro, Gwangju 61186, South Korea; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Ng, How Yong/A-3153-2013; Mameda, Dr. Naresh/AAV-2711-2020; Shah, Syed Salman Ali/JCE-1663-2023; Mameda, Naresh/AAV-2711-2020; Choo, Kwang-Ho/A-3456-2016 ⓘ 57215722996; 57901150400; 57213039681; 57192214360; 55845961700; 8566852400; 7102083272 ⓘ chookh@knu.ac.kr; ⓘ JOURNAL OF MEMBRANE SCIENCE ⓘ J MEMBRANE SCI ⓘ 0376-7388 1873-3123 717 SCIE ENGINEERING, CHEMICAL;POLYMER SCIENCE ⓘ 2024 9 4.8 0 2025-05-07 ⓘ 1 0 Biofouling control; Membrane bioreactor; Non-solvent induced phase separation; Porous silica; Quorum quenching ⓘ SURFACE CHARACTERIZATION; ENERGY-CONSUMPTION; BACTERIA; GEL; MBR; STRATEGY ⓘ Biofouling control; Membrane bioreactor; Non-solvent induced phase separation; Porous silica; Quorum quenching ⓘ Cells; Encapsulation; Hardiness; Matrices; Media; Quenching; Silica; Solvents; Encapsulation; hydrogel; n,n dimethylacetamide; polysulfone; silicon dioxide; Bio-media; Biofouling control; Membrane bioreactor; Non-solvent induced phase separation; Non-solvents; Polysulphone; Porous silica; Quenching media; Quorum quenching; Solvent-induced phase separations; Article; biofouling; cell viability; encapsulation; nonhuman; phase separation; quorum quenching; quorum sensing; tensile strength; Cell death ⓘ English 2025 2025-02 10.1016/j.memsci.2024.123588 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Advanced ellipse overlap computation based on segment area of circles ⓘ To address the numerical limitations that may arise when calculating the overlapping area of two ellipses using algebraic and numerical methods, we propose a novel approach aimed at improving numerical accuracy. Given two ellipses of either the standard or general types, a quaternary equation can be derived for the intersection points of the two ellipses. By solving this equation, we classify the methods for calculating the area into five types and proposed area calculation approaches for each type. In addition, we propose a method for calculating the area of a segment of an ellipse without integration. This method calculates the area of a segment of a circle with the major axis of the ellipse as its diameter and multiplies the ratio of the major axis to the minor axis. The proposed method for calculating the overlapping area of two ellipses does not require integration, enabling straightforward computation while providing high accuracy. We compared our method with the traditional Monte Carlo method and found that when the relative error is 0.0245, our method operates approximately times faster. Our research applies to fields like robotics, GIS, industrial clustering, and biology, with strong potential in medical imaging and diagnosis. ⓘ Kim, Minhye; Kim, Yongkuk; Cho, Giphil ⓘ Kyungpook Natl Univ, Dept Math, Daegu 41566, South Korea; Kangwon Natl Univ, Dept Artificial Intelligence & Software, Samcheok Si 25913, Gangwon Do, South Korea ⓘ ⓘ 59153685200; 59818548100; 56665111500 ⓘ giphil@kangwon.ac.kr; ⓘ ALEXANDRIA ENGINEERING JOURNAL ⓘ ALEX ENG J ⓘ 1110-0168 2090-2670 119 SCIE ENGINEERING, MULTIDISCIPLINARY ⓘ 2024 6.8 4.9 0 2025-05-07 ⓘ 0 0 Ellipse; Overlapping area; Segment; Intersection point; Circle; Classification ⓘ APPROXIMATION ⓘ Circle; Classification; Ellipse; Intersection point; Overlapping area; Segment ⓘ Medical robotics; Monte Carlo methods; Area calculation; Calculation approaches; Circle; Ellipse; Intersection points; Major axis; Minor axis; Numerical accuracy; Overlapping area; Segment; Medical imaging ⓘ English 2025 2025-04 10.1016/j.aej.2025.01.127 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Applying newly suggested simultaneous analysis of metabolomics and lipidomics into perfluorooctanesulfonate-derived neurotoxicity mechanism in zebrafish embryos ⓘ Developing methodologies for performing multi-omics with one sample has been challenging in zebrafish toxicology; however, related studies are lacking. A new strategy for the simultaneous analysis of metabolomics and lipidomics in zebrafish embryos was proposed and applied to explore the neurotoxicity mechanisms of perfluorooctanesulfonate (PFOS). Metabolite and lipid profiled simultaneously with methyl tert-butyl ether (MTBE) were compared with individual results from other extraction solvents. Behavioral alterations were measured after the zebrafish embryos were exposed to 0.1-20 mu M PFOS for 5 days. The metabolite-lipid profiles of the MTBE-based strategy analyzed with optimized larval pooling size of 30 were comparable to those of other extraction solvents, indicating the feasibility and efficiency of MTBE-based multi-omics analysis. Many metabolites and lipids, which were enriched more than those previously reported, completed the toxicity pathways involved in energy metabolism and sphingolipids, improving our understanding of PFOS-induced neurotoxicity mechanism manifested by increased movement under dark conditions. Our novel MTBE-based strategy enabled the multi-omics analysis of one sample with minimal use of zebrafish embryos, thereby improving data reliability on changes in multi-layered biomolecules. This study will advance multi-omics technologies that are critical to elucidating the toxicity mechanisms of toxic chemicals including per- and polyfluoroalkyl substances. ⓘ Min, Eun Ki; Park, So-Young; Liu, Kwang-Hyeon; Kim, Ki-Tae ⓘ Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 FOUR Community Based Intelligent Novel Drug D, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea ⓘ KIM, KI-TAE/AAX-3175-2020 ⓘ 57221692953; 57211630074; 55768214700; 57202074566 ⓘ ktkim@seoultech.ac.kr; ⓘ JOURNAL OF HAZARDOUS MATERIALS ⓘ J HAZARD MATER ⓘ 0304-3894 1873-3336 484 SCIE ENVIRONMENTAL SCIENCES;ENGINEERING, ENVIRONMENTAL ⓘ 2024 11.3 4.9 0 2025-05-07 ⓘ 1 1 PFAS; Multi-omics; Molecular mechanism; Biomarker; Sphingolipid; MTBE ⓘ TERT-BUTYL ETHER; EXTRACTION; CERAMIDE; CELL ⓘ Biomarker; Molecular mechanism; MTBE; Multi-omics; PFAS; Sphingolipid ⓘ Alkanesulfonic Acids; Animals; Behavior, Animal; Embryo, Nonmammalian; Fluorocarbons; Lipidomics; Metabolomics; Methyl Ethers; Neurotoxicity Syndromes; Water Pollutants, Chemical; Zebrafish; Biomarkers; Biomolecules; Liver; Solvent extraction; Sphingosines; lipid; lipidome; perfluorooctanesulfonic acid; protein; tert butyl methyl ether; alkanesulfonic acid; dimethyl ether; fluorocarbon; perfluorooctanesulfonic acid; 'omics'; Methyl tert butyl ether; Molecular mechanism; Multi-omic; Neurotoxicity; Perfluorooctane sulfonates; PFAS; Simultaneous analysis; Sphingolipids; Zebrafish embryos; behavioral response; biomarker; chemical compound; embryo; fish; lipid; metabolism; toxicity; animal experiment; animal model; Article; comparative study; controlled study; embryo; exposure; feasibility study; lipid fingerprinting; lipidomics; metabolite; metabolome; metabolomics; multiomics; neurotoxicity; nonhuman; size; solvent extraction; zebra fish; animal; animal behavior; drug effect; embryology; etiology; metabolism; neurotoxicity; nonmammalian embryo; toxicity; water pollutant; Metabolites ⓘ English 2025 2025-02-15 10.1016/j.jhazmat.2024.136712 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Physics driven interpretable deep learning-based insights into boiling crisis of smooth and roughened surfaces ⓘ The safety and reliability of phase change equipment in many applications rely on accurate prediction of pool boiling critical heat flux (CHF). The existing predictive models (empirical correlations or some semi-analytically based theoretical approaches) generally predict the CHF with very large errors owing to the vague pool boiling phenomenon. Herein, a physics informed and interpretable artificial intelligence based predictive model was developed to accurately predict the CHF using deep neural network (DNN) for a range of smooth and roughened surfaces with diverse working fluids and pool boiling conditions. An automatic k-fold method known as Bayesian surrogate models (Gaussian process, Gradient boost regression trees, Random forest) is used to provide an optimal and stable model while incorporating big database regarding CHF. Through empirical correlations developed in 42 pool boiling studies incorporated with 29 working fluids on various surfaces and correlation matrix or data-based correlations such as Pearson correlation, Kendall correlation, and Spearman correlation, we have identified the key input parameters based on surface morphologies, pool boiling conditions, and thermophysical features to predict CHF (the accuracy achieved R2 = 0.97). Moreover, the interpretable artificial intelligence (XAI) has been used to shed a light on the DNN's predictions. The XAI reveals that surface inclination is the most influential parameter followed by liquid saturation temperature, material conductivity, Delta T, and surface roughness for the investigated data range. The parameter sensitivity analysis strongly agrees with XAI. ⓘ Sajjad, Uzair; Mehdi, Sadaf; Hussain, Imtiyaz; Rehman, Tauseef-ur; Sultan, Muhammad; Rashidi, Mohammad Mehdi; Yan, Wei-Mon ⓘ Natl Taipei Univ Technol, Dept Energy & Refrigerat Air Conditioning Engn, Taipei 10607, Taiwan; Natl Taipei Univ Technol, Res Ctr Energy Conservat New Generat Residential C, Taipei 10608, Taiwan; Purdue Univ, Sch Mech Engn, 585 Purdue Mall, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Bahauddin Zakariya Univ, Dept Agr Engn, Multan 60800, Pakistan; Univ Elect Sci & Technol China, Chengdu 610056, Sichuan, Peoples R China ⓘ Sultan, Muhammad/AAE-7883-2020; Rehman, Tauseef-ur/AAE-3086-2022; Sajjad, Uzair/AAV-8645-2021; MEHDI, SADAF/GQQ-3397-2022 ⓘ 57202950663; 57216623079; 57221769068; 57159403400; 56532340300; 57189276752; 57200197835 ⓘ energyengineer01@gmail.com; mm_rashidi@yahoo.com; wmyan1234@gmail.com; ⓘ ALEXANDRIA ENGINEERING JOURNAL ⓘ ALEX ENG J ⓘ 1110-0168 2090-2670 116 SCIE ENGINEERING, MULTIDISCIPLINARY ⓘ 2024 6.8 4.9 0 2025-05-07 ⓘ 1 1 Boiling crisis; Pool boiling heat transfer; Physics informed deep learning; Interpretable artificial intelligence; Energy Efficiency ⓘ CRITICAL HEAT-FLUX; SINGLE BUBBLE DYNAMICS; CU SURFACES; POOL; ROUGHNESS; CHF; NUCLEATION; MODEL; ENHANCEMENT; SATURATION ⓘ Boiling crisis; Energy Efficiency; Interpretable artificial intelligence; Physics informed deep learning; Pool boiling heat transfer ⓘ Deep neural networks; Boiling crisis; Empirical correlations; Energy; Interpretable artificial intelligence; Physic informed deep learning; Pool boiling; Pool boiling heat transfer; Predictive models; Roughened surfaces; Smooth surface; Sensitivity analysis ⓘ English 2025 2025-03 10.1016/j.aej.2024.10.103 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Synthesis and performance evaluation of bentonite co-doped with sulfur and bromine for selective radionuclide sequestration from aqueous environments ⓘ This study investigates the synthesis and application of bentonite co-doped with sulfur and bromine (S/Br-B-2.0) as a novel, scalable adsorbent for the selective removal of 60Co and 85,90Sr, which are significant contaminants in liquid radioactive waste, with the aim of overcoming the limitations of conventional treatment methods. The material was synthesized by a hydrothermal method and characterized by XRD, FE-SEM, BET, FTIR, XPS, and zeta potential analysis. The adsorption kinetics revealed different mechanisms: 60Co followed a pseudo-second-order model, suggesting chemisorption, while 85,90Sr followed a Elovich model, applied to heterogeneous surfaces, highlighting variations in surface activity and activation energy. Isothermal studies showed that 60Co adsorption followed the Freundlich model, indicating multilayer adsorption with a maximum capacity of 46.66 mg/g, while 85,90Sr followed the Langmuir model, indicating monolayer adsorption with a capacity of 43.20 mg/g. Batch experiments confirmed consistent performance over pH, temperature, and dosage variations. Reusability tests showed moderate retention of adsorption capacity after five cycles, proving the durability of the material. Response surface methodology optimized the adsorption process by analyzing the effects of pH, temperature, concentration, and contact time. The results highlight the potential of S/Br-B-2.0 as an efficient and sustainable solution for radionuclide removal, particularly for managing liquid radioactive waste in water treatment and environmental remediation. ⓘ Cha, Byungjun; Yea, Yeonji; Kim, Sewoon; Njaramba, Lewis Kamande; Yoon, Yeomin; Park, Chang Min ⓘ Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ Iowa, Dept Civil & Environm Engn, lowa City, IA 52242 USA; Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea ⓘ Park, Chang Min/CAA-8506-2022; Kamande, Lewis/JLL-5435-2023 ⓘ 57337280900; 57217304205; 57201422323; 57223183206; 7402126688; 57209588953 ⓘ chabss7@gmail.com; dpduswl@naver.com; sewoon-kim@uiowa.edu; lewiskamande@gmail.com; yoony@ewha.ac.kr; cmpark@knu.ac.kr; ⓘ JOURNAL OF HAZARDOUS MATERIALS ⓘ J HAZARD MATER ⓘ 0304-3894 1873-3336 492 SCIE ENVIRONMENTAL SCIENCES;ENGINEERING, ENVIRONMENTAL ⓘ 2024 11.3 4.9 0 2025-05-07 ⓘ 1 1 Radionuclide; Adsorption; Bentonite; Bromine; Sulfur ⓘ ADSORPTION-KINETICS; ACTIVATED BENTONITE; REMOVAL; PB(II); WATER; XPS; STRONTIUM; NITROGEN; CO(II); IONS ⓘ Adsorption; Bentonite; Bromine; Radionuclide; Sulfur ⓘ Bioremediation; Monolayers; Radioactive wastes; Wastewater treatment; aluminum; bentonite; bromine; carbon; cobalt 60; hydroxyl group; oxygen; radioisotope; silicate; silicon; strontium 90; sulfur; adsorbent; Aqueous environment; Co-doped; Conventional treatments; Hydrothermal methods; Liquid radioactive wastes; Performances evaluation; Selective removal; Synthesis evaluation; Synthesised; Treatment methods; adsorption; bentonite; bromine; durability; radioactive waste; radionuclide; reaction kinetics; water treatment; adsorption; adsorption kinetics; Article; bioremediation; chemical composition; chemisorption; desorption; energy dispersive X ray spectroscopy; field emission scanning electron microscopy; Fourier transform infrared spectroscopy; pH; phase transition; radioactive waste; response surface method; scanning electron microscopy; synthesis; temperature; thermogravimetry; water treatment; X ray diffraction; X ray photoemission spectroscopy; zeta potential; article; contact time; controlled study; ecosystem restoration; Fourier transform infrared spectrometer; pharmaceutics; radioactive waste; Reusability ⓘ English 2025 2025-07-15 10.1016/j.jhazmat.2025.138244 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Review ⓘ Unraveling the gut microbiota's role in Rheumatoid arthritis: dietary pathways to modulation and therapeutic potential ⓘ Rheumatoid arthritis (RA) is a significant global health issue. Recent research highlights the gut microbiota's critical role in RA's development, noting how dietary factors can alter these microbial communities. This has led to an increased focus on how the gut microbiota (GM) influences RA and the potential for dietary ingredients to offer anti-RA benefits by modifying GM. This review presents a concise examination of the GM associated with RA, identifying specific microbial taxa at various levels that are implicated in the disease. It delves into dietary components known for their anti-RA properties through GM modulation and their mechanisms. Findings from numerous studies, including both animal and human research, show significant differences in the GM composition between individuals with early and established RA. Certain microbes like Tenericutes, Synergistetes, and Proteobacteria have been linked to RA progression, whereas Bacteroidetes and some strains of Lactobacillus are shown to have protective effects against RA. Dietary elements such as fibers, polysaccharides, resistant starch, and peptides have been identified as influential in combating RA. These components work by altering the GM's metabolites and impacting immune cells related to the GM. This review suggests the potential for developing functional foods aimed at treating RA by targeting GM. ⓘ Shan, Lingyue; Chelliah, Ramachandran; Rahman, Syed Mohammad Ehsanur; Hwan Oh, Deog ⓘ Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Food Sci & Biotechnol, Chunchon, South Korea; Future F Biotech Co Ltd, Chunchon, South Korea; Bangladesh Agr Univ, Dept Anim Sci, Mymensingh, Bangladesh ⓘ Oh, Deog-Hwan/AHE-4751-2022; Shan, Lingyue/LTZ-8810-2024; Rahman, Syed Mahbubur/N-4715-2015 ⓘ ⓘ deoghwa@kangwon.ac.kr; ⓘ CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION ⓘ CRIT REV FOOD SCI ⓘ 1040-8398 1549-7852 65 17 SCIE FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS ⓘ 2024 8.8 4.9 ⓘ 7 Rheumatoid arthritis; gut microbiota; RA model; food ingredients; inflammation ⓘ COLLAGEN-INDUCED ARTHRITIS; PROBIOTIC SUPPLEMENTATION; HYGIENE HYPOTHESIS; LACTOBACILLUS; AUTOANTIBODIES; ACTIVATION; DISORDERS; INDUCTION; RESPONSES; IMMUNITY ⓘ ⓘ ⓘ English 2025 2025-06-23 10.1080/10408398.2024.2362412 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Rapid spread of Amitraz resistance linked to a unique T115N mutation in the octopamine receptor of Varroa mites in Korea ⓘ The Varroa mite, Varroa destructor, is an ectoparasitic pest of Western honey bees and poses a significant threat to apiculture. In Korea, widespread fluvalinate resistance has increased reliance on amitraz as an alternative acaricide. This study identified a novel mutation, T115N, in the (32-adrenergic-like octopamine receptor gene (Oct beta 2R) and confirmed its role in amitraz resistance. Genotyping of individual mites, based on time-dependent intoxication responses to a diagnostic dose of amitraz, revealed a strong correlation between genotype and resistance phenotype: mites with early intoxication responses were homozygous for the T115 allele, whereas those with delayed responses predominantly carried the homozygous N115 allele. Mites with homozygous N115 genotype exhibited a median lethal time approximately 2.8-fold longer than their T115 counterparts, confirming the resistance conferred by the T115N mutation. Quantitative sequencing was established to track the spread dynamics of T115N mutation in Korean Varroa mite populations over five years (2020-2024). While the mutation was rare from 2020 to 2022, its frequency increased sharply in 2023 and became widespread across Korea by 2024, coinciding with increased amitraz usage. These findings suggest region-specific selection for the T115N mutation driven by amitraz exposure. ⓘ Lee, Joonhee; Lee, Jong Hyeok; Lim, Youngcheon; Cho, Susie; Moon, Kyunghwan; Kim, Sanghyeon; Kim, Young Ho; Lee, Si Hyeock ⓘ Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea; Kyungpook Natl Univ, Dept Vector Entomol, Sangju 37224, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Kyungpook Natl Univ, Res Inst Invertebrate Vector, Sangju 37224, South Korea ⓘ ⓘ 57562565200; 57789908800; 57966774300; 57215506355; 57202874378; 57203773859; 59818809000; 58477188500 ⓘ shlee22@snu.ac.kr; ⓘ PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY ⓘ PESTIC BIOCHEM PHYS ⓘ 0048-3575 1095-9939 210 SCIE BIOCHEMISTRY & MOLECULAR BIOLOGY;ENTOMOLOGY;PHYSIOLOGY ⓘ 2024 4 5.0 0 2025-05-07 ⓘ 0 0 Varroa mite; Amitraz resistance; Octopamine receptor; T115N mutation; 3D modeling ⓘ ⓘ 3D modeling; Amitraz resistance; Octopamine receptor; T115N mutation; Varroa mite ⓘ Acaricides; Animals; Drug Resistance; Genotype; Mutation; Receptors, Biogenic Amine; Republic of Korea; Toluidines; Varroidae; acaricide; amitraz; norsynephrine receptor; receptor; toluidine derivative; animal; drug effect; drug resistance; genetics; genotype; mutation; South Korea; Varroidae ⓘ English 2025 2025-05 10.1016/j.pestbp.2025.106387 ⓘ 바로가기 바로가기 바로가기 바로가기
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