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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | Should Visceral Pleural Invasion Be Prognostic Factor in Early-Stage Lung Adenocarcinoma With Tumor Size 3cm or Less? | Park, K.; Jeon, Y.; Bae, C.; Lee, E. | Daegu Cathol Med Ctr, Daegu, South Korea; DCMC, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea | Kim, Taejoon/JQI-3924-2023 | JOURNAL OF THORACIC ONCOLOGY | J THORAC ONCOL | 1556-0864 | 1556-1380 | 17 | 9 | SCIE | ONCOLOGY;RESPIRATORY SYSTEM | 2022 | 20.4 | 5.2 | 0 | early lung cancer; Solid; visceral pleura | English | 2022 | 2022-09 | 바로가기 | 바로가기 | ||||||||||||||
| ○ | ○ | Article | Structural and physicochemical properties of composites between starch nanoparticles and ?-carotene prepared via nanoprecipitation | To apply starch nanoparticles (SNP) as host materials for 13-carotene encapsulation, aqueous SNP dispersions (10, 25, 50, and 100 mg/10 mL) and 13-carotene in acetone (10, 50, 100, 150, and 200 mu g/mL) were mixed. The acetone in the mixture was evaporated to prepare SNP and 13-carotene composites, which were homogeneously dispersed in aqueous media with over 90 % solubility. When SNP content was higher than 50 mg, over 80 % of 13-carotene was encapsulated in the composite matrix. X-ray diffraction, nuclear magnetic resonance spectroscopy, and transmission electron microscopic analyses confirmed the micellar-shaped composite particles with diameters <120 nm and an amorphous structure. High SNP content in the composites enhanced 13-carotene stability under extremely hot and acidic conditions as well as against ultraviolet rays and oxidation reactions. The encapsulated 13-carotene was not readily released in simulated gastric fluid, but was gradually released in simulated intestinal fluid via SNP digestion in the composites. | Lee, Dong Heon; Kwon, Kang Sik; Jeong, Duyun; Kim, In Ho; Nam, Hee Soo; Kim, Jong-Yea | Kangwon Natl Univ, Dept Food Sci & Biotechnol, Chunchon 24341, South Korea; Kyungpook Natl Univ, Dept Food & Food Serv Ind, Sangju 37224, South Korea; Bogoshinyak Co Ltd, Seoul 05855, South Korea; Kangwon Natl Univ, Inst Fermentat & Brewing, Chunchon 24341, South Korea; Kangwon Natl Univ, Dept Food Sci & Biotechnol, 1 Gangwondaehakgil, Chunchon 24341, South Korea | ; Kim, Jin Il/JWP-3629-2024 | 57750146100; 57660228200; 57203059723; 57749879400; 57749879500; 35211003900 | jongkim@kangwon.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 214 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2022 | 8.2 | 5.2 | 0.99 | 2025-06-25 | 11 | 12 | Starch nanoparticle; 13-Carotene; Encapsulation; Nanoprecipitation; Stability; Controlled release | BETA-CAROTENE; EPIDEMIOLOGIC EVIDENCE; THERMAL-DEGRADATION; STABILITY; ENCAPSULATION; ADSORPTION; KINETICS; MODEL; ACID; CORN | Controlled release; Encapsulation; Nanoprecipitation; Stability; Starch nanoparticle; β-Carotene | Acetone; beta Carotene; Micelles; Nanoparticles; Starch; acetone; beta carotene; beta cyclodextrin; chitosan; glucan 1,4 alpha glucosidase; nanoparticle; pancreatin; starch nanoparticle; tannin; unclassified drug; nanoparticle; starch; Article; biodegradability; carbon nuclear magnetic resonance; chemical oxidation; chemical phenomena; controlled study; crystallization; differential scanning calorimetry; dispersion; drug solubility; drug stability; enzymatic assay; evaporation; Fourier transform infrared spectroscopy; gelatinization; hydrodynamic diameter; hydrodynamics; hydrogen bond; infrared spectroscopy; intestine fluid; morphological adaptation; morphology; nanochemistry; nanoencapsulation; nanoprecipitation; nonhuman; nuclear magnetic resonance spectroscopy; oxidation; pH stability; photodegradation; photon correlation spectroscopy; physical chemistry; release kinetics; solid state; spectrophotometry; stomach juice; structure analysis; thermostability; transmission electron microscopy; ultraviolet irradiation; ultraviolet radiation; vacuum filtration; X ray diffraction; chemistry; micelle | English | 2022 | 2022-08-01 | 10.1016/j.ijbiomac.2022.06.062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Structural insight into a molecular mechanism of methenyltetrahydrofolate cyclohydrolase from Methylobacterium extorquens AM1 | Bioconversion of the C1 compounds into value-added products is one of the CO2-reducing strategies. In particular, because CO2 can be easily converted into formate, the efficient and direct bioconversion of CO2 through formate assimilation is attracting attention. The tetrahydrofolate (THF) cycle is the highly efficient reconstructed formate assimilation pathway, and 5,10-methenyltetrahydrofolate cyclohydrolase (FchA) is an essential enzyme involved in the THF cycle. In this study, a kinetic analysis of FchA from Methylobacterium extorquens AM1 (MeFchA) was performed and revealed that the enzyme has much higher cyclization than hydrolyzation activity, making it an optimal enzyme for formate assimilation. The crystal structure of MeFchA in the apo- and the THFcomplexed forms was also determined, revealing that the substrate-binding site of the enzyme has three differently charged regions to stabilize the three differently charged moieties of the formyl-THF substrate. The residues involved in the substrate binding were also verified through site-directed mutagenesis. This study provides a biochemical and structural basis for the molecular mechanism underlying formate assimilation. | Kim, Seongmin; Lee, Seul Hoo; Kim, Il-Kwon; Seo, Hogyun; Kim, Kyoung-Jin | Kyungpook Natl Univ, KNU Inst Microorganisms, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Kyungpook Natl Univ, KNU Inst Microorganisms, Daegu 41566, South Korea; Pohang Univ Sci & Technol, Pohang Accelerator Lab, Pohang 37673, South Korea | Kim, Kyung-Jin/MVY-3405-2025 | 57204760454; 57205261937; 56547774100; 57189697998; 55510867400 | kkim@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 202 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2022 | 8.2 | 5.2 | 0.33 | 2025-06-25 | 4 | 4 | Tetrahydrofolate cycle; Formate assimilation; 5,10-Methenyltetrahydrofolate cyclohydrolase | FORMATE-TETRAHYDROFOLATE LIGASE; CRYSTAL-STRUCTURE; PURIFICATION; DEHYDROGENASE; SYNTHETASE; CO2 | 5,10-Methenyltetrahydrofolate cyclohydrolase; Formate assimilation; Tetrahydrofolate cycle | Binding Sites; Kinetics; Methenyltetrahydrofolate Cyclohydrolase; Methylobacterium extorquens; Mutagenesis, Site-Directed; methenyltetrahydrofolate cyclohydrolase; binding site; genetics; kinetics; metabolism; Methylobacterium extorquens; site directed mutagenesis | English | 2022 | 2022-03-31 | 10.1016/j.ijbiomac.2022.01.072 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Thermoresponsive semi-interpenetrating gelatin-alginate networks for encapsulation and controlled release of scent molecules | Plant-based meats, which are nutritious foods from non-animal sources, provide clues for addressing the negative externalities associated with conventional meat production. Interest in plant-based meat has increased and is driving the rapid growth of its market. Plant-based meat should be equipped with a temperature-dependent scent release system similar to the scent release mechanism of conventional meat, to deliver a desirable meat-like flavor to consumers and obtain higher market acceptance. In this study, we prepared thermoresponsive gelatin-alginate hybrid hydrogels to control the release of scent molecules. The polymer network of gelatin alginate hydrogels was reinforced by a semi-interpenetrating network (sIPN). sIPN formation conferred resistance to external stimuli, such as shear force, swelling, and temperature, resulting in a sustained release of the meat scent. In addition, controlled size microcapsules fabricated from the same composition via an electrostatic extrusion process showed a sustained release pattern of the loaded scent at 70 degrees C, and the scent release rate was precisely controlled within an approximately 2-fold range by adjusting the alginate concentration. These observations suggest the potential use of edible biological macromolecules as food additives that can control the release of scent molecules from the plant-based meat during cooking. | Kim, Young Min; Lee, Kyungsene; Lee, Yuyeon; Yang, Kyungjik; Choe, Deokyeong; Roh, Young Hoon | Yonsei Univ, Coll Life Sci & Biotechnol, Dept Biotechnol, 50 Yonsei Ro, Seoul 03722, South Korea; Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA; Yonsei Univ, Coll Life Sci & Biotechnol, Grad Program Bioind Engn, 50 Yonsei Ro, Seoul 03722, South Korea; Kyungpook Natl Univ, Coll Agr & Life Sci, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Choe, Deokyeong/AAQ-1194-2020; Roh, Young/N-6942-2016 | 58925990500; 57220061636; 57560910400; 55791344100; 37074453400; 35879256200 | cd02da@knu.ac.kr;yr36@yonsei.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 208 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2022 | 8.2 | 5.2 | 1.89 | 2025-06-25 | 19 | 23 | Semi-interpenetrating network; Controlled release; Food additive; Gelatin; Alginate | MEAT; GELS | Alginate; Controlled release; Food additive; Gelatin; Semi-interpenetrating network | Alginates; Delayed-Action Preparations; Gelatin; Hydrogels; Odorants; alginic acid; food additive; gelatin; hydrogel; polymer; alginic acid; fragrance; Article; controlled release formulation; cooking; drug delivery system; drug screening; encapsulation; meat; microcapsule; nonhuman; physical parameters; shear strength; static electricity; sustained drug release; swelling ratio; thermoregulation; delayed release formulation; hydrogel | English | 2022 | 2022-05-31 | 10.1016/j.ijbiomac.2022.03.185 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | A review on mitigation of emerging contaminants in an aqueous environment using microbial bio-machines as sustainable tools: Progress and limitations | In recent years, the management and mitigation of emerging contaminants (ECs) and pollutants in the environment engaging various bioresources has been an incipient focus of research. The advancement of distinct processes to furnish definite requirements is immensely explored in the literature. The occurrence of manifold emerging pollutants (EPs) and the choice of a specific resource or a system to handle such xenobiotics is a challenge. Various strategies can be combined with prevailing remediation technologies to eliminate emerging contaminants from the environment effectively. However, the employment of microbial bio-machines to mitigate ECs receives a priority due to its renewable and eco-friendly approach over other chemical treatments. Microbial bioremediation and mitigatory strategies are impacted by numerous factors and operational settings in scaled-up treatments. This review focuses on the impacts of ECs on humans and ecosystems, the implication of various groups of microbes (Bacteria, Fungi, and Algae) as natural bio-machines, and systems for handling ECs in the aqueous environment. The mitigation mechanisms of selected microbial bio-machines and the merits along with challenges in mitigating ECs using unique strategies are also discussed. | Mahesh, Narayanan; Balakumar, Srinivasan; Danya, Uthaman; Shyamalagowri, Shanmugasundaram; Babu, Palanisamy Suresh; Aravind, Jeyaseelan; Kamaraj, Murugesan; Govarthanan, Muthusamy | SASTRA, Srinivasa Ramanujan Ctr, Dept Chem & Biosci, Kumbakonam 612001, Tamil Nadu, India; Nirmala Coll Women, Dept Bot, Coimbatore 641018, Tamil Nadu, India; Pachaiyappas Coll, PG & Res Dept Bot, Chennai 600030, Tamil Nadu, India; Saveetha Inst Med & Tech Sci SIMATS, Saveetha Sch Engn, Dept Biotechnol, Chennai 602105, Tamil Nadu, India; UCSI Univ, Fac Pharmaceut Sci, Kuala Lumpur 56000, Malaysia; Dhirajlal Gandhi Coll Technol, Dept Civil Engn Environm Res, Salem 636309, Tamil Nadu, India; SRM Inst Sci & Technol, Fac Sci & Humanities, Dept Biotechnol, Ramapuram Campus, Chennai 600089, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Saveetha Dental Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Biomat, Chennai 600077, India | Muthusamy, Govarthanan/C-1491-2014; Govarthanan, Muthusamy/C-1491-2014; NARAYANAN, MAHESH/AAV-1372-2021; PALANISAMY, SURESH BABU/AAH-4523-2019; murugesan, kamaraj/AAP-1422-2020; Aravind, J/O-9296-2015 | 6506740237; 24079509500; 55505011200; 57284648000; 57226597886; 23569355700; 55645159500; 54881927600 | drkamarajm@gmail.com;gova.muthu@gmail.com; | JOURNAL OF WATER PROCESS ENGINEERING | J WATER PROCESS ENG | 2214-7144 | 47 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL;WATER RESOURCES | 2022 | 7 | 5.3 | 2.56 | 2025-06-25 | 26 | 35 | Emerging contaminants; Toxicity; Biological techniques; Assorted mitigation; Eco-friendly | WASTE-WATER EFFLUENTS; BISPHENOL-A; FUNGAL TREATMENT; REMOVAL; BIODEGRADATION; DEGRADATION; MICROALGAE; PHARMACEUTICALS; SP.; DICLOFENAC | Assorted mitigation; Biological techniques; Eco-friendly; Emerging contaminants; Toxicity | English | 2022 | 2022-06 | 10.1016/j.jwpe.2022.102712 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Review | Current status and future prospects of biological routes to bio-based products using raw materials, wastes, and residues as renewable resources | Current fossil-based commercial products pose a serious threat to global reserves of natural resources and the preservation of the natural environment. During recent decades, great efforts have been made to increase the availability of non-utilizable biomass as alternative feedstocks and reduce environmental pollution to achieve a more sustainable bioeconomy. Several bio-sectors have emerged for the production of bio-based products to replace fossil-based equivalents through bioprocesses using biomass feedstocks. Indeed, advanced microbial fermentation technologies encompassing metabolic engineering and genome-based systems biology approaches have enabled the design and development of new bio-based refineries using engineered platform cells. Herein, we focus on recent progress in the area of microbial fermentation-aided bioprocesses for the production of bio-based products derived from naturally occurring biomasses as feedstocks. Furthermore, we discuss the application of bio-based products and remaining technical barriers and assess possible biorefineries. | Lee, Ji-Young; Lee, Sung-Eun; Lee, Dong-Woo | Yonsei Univ, Dept Biotechnol, Seoul 03722, South Korea; Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea | ; Lee, Jeong-Hoon/Q-1055-2018 | 58161969200; 55890041600; 57195068659 | leehicam@yonsei.ac.kr; | CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY | CRIT REV ENV SCI TEC | 1064-3389 | 1547-6537 | 52 | 14 | SCIE | ENVIRONMENTAL SCIENCES | 2022 | 12.6 | 5.3 | 1.27 | 2025-06-25 | 62 | 53 | Bio-based products; biomass; biorefinery | Bio-based products; biomass; biorefinery | Bioeconomy; Biological materials preservation; Biomass; Cell engineering; Fermentation; Metabolic engineering; Alternative feedstocks; Bio-based products; Commercial products; Design and Development; Environmental pollutions; Microbial fermentation; Natural environments; Naturally occurring; bioengineering; biology; biomass; fermentation; natural resource; renewable resource; article; biomass; bioprocess; fermentation; metabolic engineering; renewable resource; systems biology; Feedstocks | English | 2022 | 2022-07-18 | 10.1080/10643389.2021.1880259 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Efficient photocatalytic degradation of sulfasalazine and reduction of hexavalent chromium over robust In2S3/Nd2O3 heterojunction under visible light | The design and synthesis of visible light driven heterojunction photocatalyst of a novel In2S3/xNd(2)O(3) nano-composites (where x = 5, 10 and 15 wt% Nd2O3) were constructed via simple two-step process, involving hydrothermal and ultrasonication. The prepared materials were characterized extensively to reveal information about their morphology, optical properties, phase composition, chemical states and electrochemical properties. Consequently, the efficient photocatalyst were studied double role photooxidation of sulfasalazine (SSZ) and photoreduction of Cr(VI) in environmental modal water pollutants under visible light illumination. The catalytic activity of In2S3/Nd2O3 nanocomposite was found to be dependent an optimal In2S3/10wt%Nd2O3 and dose, contact time and concentration of the pollutant. The maximum efficiency attainment of the Cr(VI) reduction was 95.23% and SSZ degradation was 96.19% within 35 and 80 min, respectively, which was multi-fold times greater than the efficiency of pristine In2S3 and Nd2O3. The enhanced efficiency pointed out the proper band alignment and intimate interfacial contact in the In2S3/10 wt% Nd2O3 p-n heterojunction, which facilitate the better charge separation and transfer between In2S3 and Nd2O3 photocatalyst. The photocatalyst have superior photostability and better recyclability, after the fifth run the activity was only reduced 4% for Cr(VI) and 7% for SSZ. Finally, a plausible band alignment and favourable charge transfer pathway for the generation oxidative species were proposed depends upon the scavenger study. This study reveals the versatile nature of In2S3/xNd(2)O(3) heterojunction and its efficient photocatalysis of both emerging pharmaceutical contaminant and heavy metal in water. | Murugalakshmi, M.; Saravanakumar, Karunamoorthy; Park, Chang Min; Muthuraj, Velluchamy | VHN Senthikumara Nadar Coll Autonomous, Dept Chem, Virudunagar 626001, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea | Karunamoorthy, Saravanakumar/Q-2005-2016; Veluchamy, Muthuraj/AGO-8278-2022; Park, Chang Min/CAA-8506-2022 | 57217049959; 57223020778; 57209588953; 57203214600 | murugalaxmi25@gmail.com;sravanan205@gmail.com;cmpark@knu.ac.kr;muthuraj75@gmail.com; | JOURNAL OF WATER PROCESS ENGINEERING | J WATER PROCESS ENG | 2214-7144 | 45 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL;WATER RESOURCES | 2022 | 7 | 5.3 | 1.05 | 2025-06-25 | 13 | 14 | In2S3/Nd2O3 heterojunction; Sulfasalazine; Photodegradation; Cr(VI) photoreduction; Visible light illumination | ORGANIC-DYE DEGRADATION; NANOSTRUCTURES; NANOPARTICLES; CONSTRUCTION; NANOCOMPOSITES; FABRICATION; COMPOSITES; KINETICS | Cr(VI) photoreduction; In<sub>2</sub>S<sub>3</sub>/Nd<sub>2</sub>O<sub>3</sub> heterojunction; Photodegradation; Sulfasalazine; Visible light illumination | English | 2022 | 2022-02 | 10.1016/j.jwpe.2021.102492 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Ultrasound-assisted heterogeneous Fenton-like process for efficient degradation of tetracycline over SmFeO3/Ti3C2Tx catalyst | The relatively low performance of Fe(II) regeneration is an important problem of the conventional Fenton sys-tem. Novel SmFeO3/Ti3C2TX (SFO/TCT) catalysts were synthesized using a self-assembly method to address this shortcoming. XRD, FT-IR, XPS, SEM, HR-TEM, and BET-BJH analyses confirmed the successful synthesis of the SFO/TCT-10 composite material. The synthesized catalysts were used to degrade tetracycline (TC) under sonocatalytic and sono-Fenton catalytic processes. The SFO/TCT-10 catalyst showed excellent efficiency (99 % in 30 min) for the degradation of TC compared to SFO and TCT bare materials under the sono-Fenton process. In fact, TCT acted as the electron trapper to boost the separation and transition of generated carriers in composite material and improved its catalytic activity. The effects of different parameters on the degradation of TC with SFO/TCT-10 catalyst were studied, and the catalytic mechanism was explained. In addition, the possible degradation pathways were proposed. This study provides new insights into the synergy between SFO perovskite nanoparticles and TCT MXene in the sono-Fenton catalytic system for the degradation of TC. | Mahmoudi, Farzaneh; Park, Chang Min; Shim, Jae-Jin | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak ro, Daegu 41566, South Korea; Yeungnam Univ, Sch Chem Engn, Gyongsan 38541, South Korea | Park, Chang Min/CAA-8506-2022; Mahmoudi, Farzaneh/AAD-3765-2019; Mahmoudi, Farzaneh/R-1876-2017 | 55598593700; 57209588953; 25634762500 | cmpark@knu.ac.kr;jjshim@yu.ac.kr; | JOURNAL OF WATER PROCESS ENGINEERING | J WATER PROCESS ENG | 2214-7144 | 50 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL;WATER RESOURCES | 2022 | 7 | 5.3 | 1.43 | 2025-06-25 | 17 | 19 | Tetracycline; Degradation; Sono -Fenton; SmFeO3 | LIGHT PHOTOCATALYTIC ACTIVITY; VISIBLE-LIGHT; SONOCATALYTIC DEGRADATION; PERFORMANCE; COMPOSITE; REMOVAL; NANOCOMPOSITE; CONSTRUCTION; OXIDES | Degradation; SmFeO<sub>3</sub>; Sono-Fenton; Tetracycline; Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub> | English | 2022 | 2022-12 | 10.1016/j.jwpe.2022.103235 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo | Background: Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Methods: Cell proliferation, migration, invasion, apoptosis, cell cycle, and western blot assays were performed to evaluate the effect of G-Rh2 on CRC cells. In vitro pull-down assay was used to verify the interaction between G-Rh2 and Axl. Transfection and infection experiments were used to explore the function of Axl in CRC cells. CRC xenograft models were used to further investigate the effect of Axl knockdown and G-Rh2 on tumor growth in vivo. Results: G-Rh2 significantly inhibited proliferation, migration, and invasion, and induced apoptosis and G(0)/G(1) phase cell cycle arrest in CRC cell lines. G-Rh2 directly binds to Axl and inhibits the Axl signaling pathway in CRC cells. Knockdown of Axl suppressed the growth, migration and invasion ability of CRC cells in vitro and xenograft tumor growth in vivo, whereas overexpression of Axl promoted the growth, migration, and invasion ability of CRC cells. Moreover, G-Rh2 significantly suppressed CRC xenograft tumor growth by inhibiting Axl signaling with no obvious toxicity to nude mice. Conclusion: Our results indicate that G-Rh2 exerts anticancer activity in vitro and in vivo by suppressing the Axl signaling pathway. G-Rh2 is a promising candidate for CRC prevention and treatment. (C) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Zhang, Haibo; Yi, Jun-Koo; Huang, Hai; Park, Sijun; Kwon, Wookbong; Kim, Eungyung; Jang, Soyoung; Kim, Si-Yong; Choi, Seong-kyoon; Yoon, Duhak; Kim, Sung-Hyun; Liu, Kangdong; Dong, Zigang; Ryoo, Zae Young; Kim, Myoung Ok | Kyungpook Natl Univ, Dept Anim Sci & Biotechnol, ITRD, Sangju 37224, Gyeongsangbukdo, South Korea; Gyeongbuk Livestock Res Inst, Yeongju, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes, Daegu, South Korea; DGIST, Div Biotechnol, Daegu, South Korea; DGIST, Core Prot Resources Ctr, Daegu, South Korea; Korea Polytech Coll, Dept Biomed Anal, Chungnam, South Korea; China US Henan Hormel Canc Inst, Zhengzhou, Peoples R China | RYOO, ZAEYOUNG/AAQ-1573-2020; Yi, Junkoo/JBR-8507-2023; Zhang, Haibo/HLP-9266-2023 | 57221648126; 56182537200; 57215021952; 54682212300; 57139843600; 57217871658; 57139360300; 57212197751; 55505432500; 7202875754; 59103241900; 56890019100; 57225955964; 16937104900; 8934745900 | jaewoong64@hanmail.net;ok4325@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 2.32 | 2025-06-25 | 17 | 19 | 20(S)-ginsenoside Rh2; Axl; Colorectal cancer; Xenograft | RECEPTOR TYROSINE KINASE; EGFR-TKI; RESISTANCE; PI3K/AKT; SURVIVAL; ERK1/2; SRC; PROLIFERATION; CHEMOTHERAPY; ACTIVATION | 20(S)-ginsenoside Rh2; Axl; Colorectal cancer; Xenograft | animal cell; animal experiment; animal model; antineoplastic activity; apoptosis; article; cancer growth; cancer prevention; cell cycle arrest; cell cycle G0 phase; cell cycle G1 phase; cell migration; cell proliferation; cell viability; colorectal cancer cell line; controlled study; gene overexpression; genetic transfection; in vitro study; in vivo study; male; mouse; nonhuman; nude mouse; signal transduction; tumor growth; tumor xenograft; Western blotting | English | 2022 | 2022-05 | 10.1016/j.jgr.2021.07.004 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Comparative antiplatelet and antithrombotic effects of red ginseng and fermented red ginseng extracts | Background: Fermentation may alter the bioavailability of certain compounds, which may affect their efficacy and pharmacological responses. This study investigated the antiplatelet effects of red ginseng extract (RGE) and fermented red ginseng extract (FRG). Methods: A rodent model was used to evaluate the antiplatelet and antithrombotic effects of the extracts. Rats were orally fed with human equivalent doses of the extracts for 1 week and examined for various signaling pathways using standard in vivo and ex vivo techniques. Light transmission aggregometry was performed, and calcium mobilization, dense granule secretion, integrin aIIbb3-mediated signaling molecules, cyclic nucleotide signaling events, and various protein molecules were evaluated ex vivo in collagen-stimulated washed platelets. Furthermore, antithrombotic properties were evaluated using a standard acute pulmonary thromboembolism model, and the effects on hemostasis were investigated using rat and mice models. Results: Both RGE and FRG significantly inhibited platelet aggregation, calcium mobilization, and dense granule secretion along with integrin-mediated fibrinogen binding and fibrinogen adhesion. cAMP levels were found to be elevated in RGE-treated rat platelets. Ginseng extracts did not exert any effect on prothrombin time and activated partial thromboplastin time. RGE-treated mice showed significantly better survival under thrombosis than FRG-treated mice, with no effects on hemostasis, whereas FRGtreated mice exhibited a slight increment in bleeding time. Conclusion: Both extracts, especially RGE, are remarkable supplements to maintain cardiovascular health and are potential candidates for the treatment and prevention of platelet-related cardiovascular disorders. ?? 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Irfan, Muhammad; Lee, Yuan Yee; Lee, Ki-Ja; Kim, Sung Dae; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu 41566, South Korea; Univ Illinois, Dept Oral Biol, Chicago, IL USA | ; Yuan Yee, Lee/ABH-8956-2022; Rhee, Man/O-5705-2016; Irfan, Muhammad/AAY-1961-2021 | 35069404400; 57203798815; 35311016000; 55156746000; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 3 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 1.47 | 2025-06-25 | 7 | 12 | Antiplatelet; Antithrombotic; Fermentation; Panax ginseng; Thrombosis | INHIBITS PLATELET ACTIVATION; THROMBUS FORMATION; CARDIOVASCULAR-DISEASE; GLYCOPROTEIN IIB/IIIA; TOTAL SAPONIN; PHOSPHORYLATION; KINASES; ASPIRIN; MICE | Antiplatelet; Antithrombotic; Fermentation; Panax ginseng; Thrombosis | acetylsalicylic acid; adenosine diphosphate; adenosine triphosphate; alpha2beta3 integrin; anticoagulant agent; antithrombocytic agent; collagen; cyclic AMP; cyclic AMP dependent protein kinase; cyclic GMP; cyclic nucleotide; cyclooxygenase 1; fermented red ginseng extract; fibrinogen; fibrinogen receptor; ginseng extract; ginsenoside Rb 1; ginsenoside Rg 1; ginsenoside Rg 3; integrin; mitogen activated protein kinase p38; phosphatidylinositol 3 kinase; protein kinase B; red ginseng extract; thrombin; thromboxane A2; thromboxane B2; unclassified drug; activated partial thromboplastin time; animal cell; animal experiment; animal model; animal tissue; antiplatelet activity; antithrombotic activity; Article; binding affinity; calcium mobilization; clinical evaluation; comparative study; controlled study; drug granule; ex vivo study; fermentation; ginseng; hemostasis; in vivo study; lung embolism; male; mouse; nonhuman; platelet aggregation assay; protein secretion; prothrombin time; rat; rodent model; signal transduction; survival rate; thrombocyte aggregation | English | 2022 | 2022-05 | 10.1016/j.jgr.2021.05.010 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | COVID-19 and Panax ginseng: Targeting platelet aggregation, thrombosis and the coagulation pathway | Coronavirus disease 2019 (COVID-19) not only targets the respiratory system but also triggers a cytokine storm and a series of complications, such as gastrointestinal problems, acute kidney injury, and myocardial ischemia. The use of natural products has been utilized to ease the symptoms of COVID-19, and in some cases, to strengthen the immune system against COVID-19. Natural products are readily available and have been regularly consumed for various health benefits. COVID-19 has been reported to be associated with the risk of thromboembolism and deep vein thrombosis. These thrombotic complications often affects mortality and morbidity. Panax ginseng, which has been widely consumed for its various health benefits has also been reported for its therapeutic effects against cardiovascular disease, thrombosis and platelet aggregation. In this review, we propose that P. ginseng can be consumed as a supplementation against the various associated complications of COVID-19, especially against thrombosis. We utilized the network pharmacology approach to validate the potential therapeutic properties of P. ginseng against COVID-19 mediated thrombosis, the coagulation pathway and platelet aggregation. Additionally, we aimed to investigate the roles of P. ginseng against COVID-19 with the involvement of platelet-leukocyte aggregates in relation to immunity-related responses in COVID-19. (c) 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lee, Yuan Yee; Quah, Yixian; Shin, Jung-Hae; Kwon, Hyuk-Woo; Lee, Dong-Ha; Han, Jee Eun; Park, Jin-Kyu; Kim, Sung Dae; Kwak, Dongmi; Park, Seung-Chun; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Ginseng Circulaton Lab, Daegu, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu, South Korea; Korea Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon, South Korea; Far East Univ, Dept Biomed Lab Sci, Eumseong, South Korea; Namseoul Univ, Dept Biomed Lab Sci, Cheonan, South Korea | ; Park, Seung-Chun/AAV-3388-2021; Rhee, Man/O-5705-2016; Yixian, Quah/ABE-7629-2021; Yuan Yee, Lee/ABH-8956-2022 | 57203798815; 55886933200; 56244056800; 55200547400; 57208891222; 57214671240; 35213723500; 55156746000; 7007148758; 7501832396; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 2 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 0.57 | 2025-06-25 | 9 | 10 | Panax ginseng; Coagulation; Thrombosis; Platelet aggregation; COVID-19 | RED GINSENG; P-SELECTIN; IN-VIVO; CORONAVIRUS; ACTIVATION; PROTEIN; PLAQUE; ACE2 | Coagulation; COVID-19; Panax ginseng; Platelet aggregation; Thrombosis | herbaceous agent; integrin; integrin alphaIIbbeta3; PADGEM protein; phosphatidylinositol 3 kinase; protein kinase B; thromboxane A2; unclassified drug; blood clotting; coronavirus disease 2019; diet supplementation; fibrinolysis; gene identification; ginseng; human; leukocyte; nonhuman; Pi3K/Akt signaling; Review; systems pharmacology; therapy effect; thrombocyte aggregation; thromboembolism; thrombosis | English | 2022 | 2022-03 | 10.1016/j.jgr.2022.01.002 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | DK-MGAR101, an extract of adventitious roots of mountain ginseng, improves blood circulation by inhibiting endothelial cell injury, platelet aggregation, and thrombus formation | Background: Since ginsenosides exert an anti-thrombotic activity, blood flow-improving effects of DK-MGAR101, an extract of mountain ginseng adventitious roots (MGAR) containing various ginsenosides, were investigated in comparison with an extract of Korean Red Ginseng (ERG). Methods: In Sprague-Dawley rats orally administered with DK-MGAR101 or ERG, oxidative carotid arterial thrombosis was induced with FeCl3 (35%), and their blood flow and occlusion time were measured. To elucidate underlying mechanisms, the cytoprotective activities on rat aortic endothelial cells (RAOECs) exposed to hydrogen peroxide (H2O2) were confirmed. In addition, the inhibitory activities of DK-MGAR101 and ERG on agonist-induced platelet aggregation, thromboxane B-2 production, and ATP granule release from stimulated platelets as well as blood coagulation were analyzed. Results: DK-MGAR101 containing high concentrations of Rbl, Rgl, Rg3, Rg5, and Rk1 ginsenosides (55.07 mg/g) was more effective than ERG (ginsenosides 8.45 mg/g) in protecting RAOECs against H2O2 cytotoxicity. DK-MGAR101 was superior to ERG not only in suppressing platelet aggregation, thromboxane B-2 production, and granule release, but also in delaying blood coagulation, FeCl3 -induced arterial occlusion, and thrombus formation. Conclusions: The results indicate that DK-MGAR101 prevents blood vessel occlusion by suppressing platelet aggregation, thrombosis, and blood coagulation, in addition to endothelial cell injury. (C) 2022 The Korean Society of Ginseng. Publishing services by Elsevier B.V. | Seong, Hye Rim; Wang, Cuicui; Irfan, Muhammad; Kim, Young Eun; Jung, Gooyoung; Park, Sung Kyeong; Kim, Tae Myoung; Choi, Ehn-Kyoung; Rhee, Man Hee; Kim, Yun-Bae | Chungbuk Natl Univ, Coll Vet Med, 1 Chungdaero, Cheongju 28644, Chungbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea; Dongkook Pharmaceut Co Ltd, Pharmaceut Technol Inst, Jincheon, South Korea; Daejeon Hlth Inst Technol, Dept Beauty Care, Daejeon, South Korea | Irfan, Muhammad/AAY-1961-2021; kim, jeongha/HHS-1379-2022; Kim, Jung/L-9791-2019; Wang, Cuicui/P-8578-2019; Rhee, Man/O-5705-2016; Kim, Kwang Pyo/AAG-1815-2020 | 57226748742; 57417695900; 57223918800; 55589334800; 57211456110; 57191673882; 36910702800; 36909978300; 57211035357; 8260553900 | solar93@cbu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 5 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 0.86 | 2025-06-25 | 7 | 7 | Adventitious root; Blood circulation; Ginsenoside; Mountain ginseng; Platelet aggregation | PANAX-GINSENG; ANTIOXIDANT ACTIVITIES; WATER EXTRACT; COLLAGEN; ASPIRIN; ACTIVATION; GINSENOSIDES; EXPRESSION; ADHERENCE; ARTERIAL | Adventitious root; Blood circulation; Ginsenoside; Mountain ginseng; Platelet aggregation | English | 2022 | 2022-09 | 10.1016/j.jgr.2022.01.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Healthcare Resource Utilization After Living Liver Donation: A Retrospective Case-Control Study | Background. Living liver donation is generally considered safe, but donors may experience short- or long-term complications. The purpose of this study was to assess healthcare resource utilization after liver donation in living liver donors in comparison with the general population. Methods. Outpatient or emergency department visits and hospital admissions were compared between living liver donors who underwent hepatic resection for living liver donation between 2004 and 2018 and the matched general population. Healthcare resource utilization data for 5 y after liver donation were collected from the National Health Insurance Service database. For every living liver donor, 4 individually matched nondonors were selected from the National Health Insurance Service database using age, sex, preexisting comorbidities, and previous healthcare utilization history. Results. A total of 1886 living liver donors and 7309 nondonors were included. In the first year after donation, living liver donors required more outpatient department visits (7 [4-13] versus 3 [1-7], P < 0.001) and more emergency department visits (13.33% versus 0.15%, P < 0.001) compared with matched nondonors. A similar trend persisted for 5 y after donation. The number of hospital admissions of living liver donors was higher for up to 2 y after donation with longer hospital length of stay (13.0 [10.5-16.0] d versus 5.0 [3.0-9.0] d, P < 0.0001). Conclusions. Healthcare resource utilization in living liver donors for 5 y after donation was higher compared with matched nondonors. The higher healthcare resource demand may be related to postoperative complications or lowered threshold for healthcare resource utilization after donation. | Im, Hyunjae; Jang, Eun Jin; Jo, Junwoo; Choe, Suk Hyung; Joo, Somin; Lee, Hannah; Oh, Seung-Young; Hong, Suk Kyun; Ryu, Ho Geol | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Anesthesiol & Pain Med, Coll Med, Daehak Ro 101, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Crit Care Med, Coll Med, Seoul, South Korea; Andong Natl Univ, Dept Informat Stat, Andong, South Korea; Kyungpook Natl Univ, Dept Stat, Daegu, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Surg, Coll Med, Seoul, South Korea | Ryu, Ho/J-5463-2012 | 57680911500; 37861741600; 57210425017; 57219612371; 57726504400; 55634905800; 55930541200; 57191476351; 7202277246 | hogeol@gmail.com; | TRANSPLANTATION | TRANSPLANTATION | 0041-1337 | 1534-6080 | 106 | 6 | SCIE | IMMUNOLOGY;SURGERY;TRANSPLANTATION | 2022 | 6.2 | 5.4 | 0.3 | 2025-06-25 | 2 | 2 | ORGAN DONATION; DONOR; TRANSPLANTATION; COMPLICATIONS; OUTCOMES; ETHICS | adult; Article; case control study; cerebrovascular disease; chronic kidney failure; controlled study; coronary artery disease; diabetes mellitus; emergency department visit; emergency ward; female; health care utilization; healthcare resource utilization; hepatectomy; hospital admission; human; hypertension; length of stay; liver donor; living liver donation; male; middle aged; outpatient department visits; outpatient department; retrospective study | English | 2022 | 2022-06 | 10.1097/tp.0000000000003958 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Panax ginseng: Inflammation, platelet aggregation, thrombus formation, and atherosclerosis crosstalk | Ginseng has been widely studied due to its various therapeutic properties on various diseases such as cardiovascular disease (CVD). Cardiovascular disease has been canonically known to be caused by high levels of low-density lipoproteins (LDL) in the bloodstream, in addition to the impaired vasodilatory effects of cholesterol. However, current research on CVD has revealed a cascade of mechanisms involving a series of events that contribute to the progression of CVD. Although this has been elucidated and summarized in previous studies the detailed correlation between platelet aggregation and innate immunity that plays an important role in CVD progression has not been thoroughly summarized. Furthermore, immune cell subtypes also contribute to the progression of plaque formation in the subendothelial layer. Thrombus formation and the coagulation cascade also have a vital role in the progression of atherosclerosis. Hence, in this mini review we aim to elucidate, summarize, and propose the potent therapeutic effect of ginseng on CVD, mainly on platelet aggregation, plaque formation, and thrombus formation. (c) 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Lee, Yuan Yee; Kim, Sung Dae; Park, Seung-Chun; Rhee, Man Hee | Kyungpook Natl Univ, Coll Vet Med, Dept Vet Med, Daegu, South Korea; Kyungpook Natl Univ, Cardiovasc Res Inst, Daegu, South Korea | ; Rhee, Man/O-5705-2016; Park, Seung-Chun/AAV-3388-2021; Yuan Yee, Lee/ABH-8956-2022 | 57203798815; 55156746000; 7501832396; 57211035357 | rheemh@knu.ac.kr; | JOURNAL OF GINSENG RESEARCH | J GINSENG RES | 1226-8453 | 2093-4947 | 46 | 1 | SCIE | CHEMISTRY, MEDICINAL;INTEGRATIVE & COMPLEMENTARY MEDICINE | 2022 | 6.3 | 5.4 | 1.48 | 2025-06-25 | 22 | 26 | Ginseng; Atherosclerosis; Platelet aggregation; Thrombus; Vulnerable plaque | KOREAN RED GINSENG; SMOOTH-MUSCLE-CELLS; LOW-DENSITY-LIPOPROTEIN; MONOCYTE RECRUITMENT; SIGNALING PATHWAY; DENDRITIC CELLS; P-SELECTIN; FOAM CELL; IN-VIVO; ACTIVATION | Atherosclerosis; Ginseng; Platelet aggregation; Thrombus; Vulnerable plaque | cholesterol; ginseng extract; tumor necrosis factor; atherosclerosis; blood clotting; cardiovascular disease; cell adhesion; ginseng; immune response; immunocompetent cell; inflammation; NF kB signaling; nonhuman; protein expression; Review; signal transduction; therapy effect; thrombocyte activation; thrombocyte aggregation | English | 2022 | 2022-01 | 10.1016/j.jgr.2021.09.003 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Pure laparoscopic living donor hepatectomy for the right posterior segment graft | Han, Y. S.; Han, J. | Kyungpook Natl Univ, Sch Med, Liver Transplantat & Hepatobiliary Pancreas Surg, Kyungpook Natl Univ Hosp, Daegu, South Korea | TRANSPLANTATION | TRANSPLANTATION | 0041-1337 | 1534-6080 | 106 | 8S | SCIE | IMMUNOLOGY;SURGERY;TRANSPLANTATION | 2022 | 6.2 | 5.4 | 0 | English | 2022 | 2022-08 | 바로가기 | 바로가기 |
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