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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | Meeting Abstract | REVISITING THE IMPACT OF HBEAG-STATUS OF ANTIVIRAL TREATMENT ON RISK OF HEPATOCELLULAR CARCINOMA DEVELOPMENT: A NATIONWIDE MULTICENTER STUDY | Jang, Heejoon; Yoon, Jun Sik; Kim, Hwi Young; Park, Soo Young; Kim, Seung Up; Sinn, Dong Hyun; Seo, Yeon Seok; Lee, Han Ah; Kim, Sung Eun; Jun, Dae Won; Yoon, Eileen; Sohn, Joo Hyun; Ahn, Sang Bong; Shim, Jae-Jun; Jeong, Soung Won; Cho, Yong Kyun; Kim, Hyoung Su; Lee, Yun Bin; Cho, Eun Ju; Yu, Su Jong; Kim, Yoon Jun; Yoon, Jung-Hwan; Lee, Jeong-Hoon | Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ Hosp, Liver Res Inst, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Internal Med 2, Coll Med, Busan, South Korea; Ewha Womans Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Yonsei Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Dept Internal Med, Samsung Med Ctr, Sch Med, Seoul, South Korea; Korea Univ, Internal Med, Coll Med, Seoul, South Korea; Korea Univ, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Dept Internal Med, Sacred Heart Hosp, Chunchon, South Korea; Hanyang Univ, Hanyang Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Coll Med, Gimhae, South Korea; Hanyang Univ, Guri Hosp, Coll Med, Dept Internal Med, Seoul, South Korea; Eulji Univ, Dept Internal Med, Sch Med, Daejeon, South Korea; Kyung Hee Univ Hosp, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Internal Med, Asan, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Sch Med, Seoul, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Chuncheon, North Korea | Sinn, Dong/JAC-4247-2023; Yoon, Jung/J-5563-2012; Kim, Sun/L-4239-2013; Jun, Dae Won/O-4529-2017; Lee, Yoojin/AAB-9799-2022; Kim, Cheol-Hee/F-6278-2013; Kim, Yong-Tae/HQZ-0240-2023; Kim, Eun Young/JCE-3602-2023; Kim, Jinyoung/LFS-2554-2024 | HEPATOLOGY | HEPATOLOGY | 0270-9139 | 1527-3350 | 72 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2020 | 17.425 | 6.0 | 0 | English | 2020 | 2020-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Characteristics of low-fat mayonnaise using different modified arrowroot starches as fat replacer | Modified arrowroot starch was investigated as a fat replacer in mayonnaise. Arrowroot starch was modified by octenyl succinic anhydride (OSA), annealing (ANN), citric acid hydrolysis (CA), acetylation (ACT) and heat-moisture treatment (HMT). The different starch pastes were used to replace mayonnaise fat at levels of 30% and 50%. Color, viscoelastic properties, and emulsion stability of the fat-reduced mayonnaises and full-fat (FF) version were evaluated, according to the type of modified starch and fat replacement ratio. Physicochemical, thermal, and pasting properties of all starch types differed due to the modification method. Shear stress of mayonnaise was fitted to the Casson and Herschel-Bulkley model, respectively. As partial fat replacers. ANN-modified starch and OSA-starch at 30%, and CA-starch at 30% and 50% showed high yield stress. The elastic moduli (G') of fat-reduced mayonnaises were lower than Fr, but mayonnaise with ANN, OSA. and CA showed higher G' than other modified starches. Fat-reduced mayonnaises displayed higher emulsion stability than the FP, especially those with ANN-modified starch, OSA-starch, and CA-starch. In principal component (PC) analysis, groups with high and low emulsion stability were divided by PC1. Overall, ANN-, OSA-, and CA-modified starches were identified as suitable fat replacers in mayonnaise. (C) 2020 Elsevier B.V. All rights reserved. | Park, Jong Jin; Olawuyi, Ibukunoluwa Fola; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Olawuyi, Ibukunoluwa/H-1232-2018; Park, Jongjin/AAL-3484-2021; Lee, Wonyoung/AAL-2780-2021 | 58602432200; 57204471854; 57195940408 | wonyoung@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 153 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2020 | 6.953 | 6.1 | 3.18 | 2025-06-25 | 75 | 87 | Arrowroot; Fat replacer; Mayonnaise; Modified starch | MICROWAVE-ASSISTED EXTRACTION; HEAT-MOISTURE TREATMENT; PHYSICOCHEMICAL PROPERTIES; FUNCTIONAL-PROPERTIES; RICE STARCH; REDUCED-FAT; RHEOLOGICAL CHARACTERIZATION; HYDROTHERMAL MODIFICATIONS; CEREAL STARCHES; CITRIC-ACID | Arrowroot; Fat replacer; Mayonnaise; Modified starch | Color; Elasticity; Fatty Acids; Food Handling; Marantaceae; Starch; Temperature; Viscosity; acid anhydride; citric acid; modified arrowroot starch; octenyl succinic anhydride; starch; unclassified drug; fatty acid; starch; Article; binding site; color; emulsion; hydrolysis; leaching; low fat mayonnaise; molecular weight; physical chemistry; processed food; shear stress; simulated annealing; thermal analysis; viscoelasticity; Young modulus; chemistry; elasticity; food handling; Marantaceae; temperature; viscosity | English | 2020 | 2020-06-15 | 10.1016/j.ijbiomac.2020.02.331 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Chitosan modified zirconium/zinc oxide as a visible light driven photocatalyst for the efficient reduction of hexavalent chromium | Metal-sensitized biopolymeric hybrid materials can be strategically utilized in photo catalysis due to the behavior of their absorption band lying in the solar radiation spectrum. Herein, chitosan supported zirconium(Zr)/zinc oxide (ZnO)) in the preparation of photo catalyst (Zr-ZnO@CS) for photocatalytic reduction of hexavalent chromium(Cr6+). Moreover, photocatalytic testing factors like exposure time of light, pH, initial Cr6+ concentration, and influence of co-anions on the removal of Cr6+ by Zr-ZnO@CS were also examined. Langmuir-Hinshelwood kinetic model suggested the surface reaction was the rate controlling step. The removal mechanism of Zr/ZnO@CS was because of enhanced properties like positive positioning of the band gap, boosted charge excitation, and higher dynamic sites. Field trial results showed that Zr-ZnO@CS hybrid photocatalyst demonstrates the potential application for the reduction of Cr6+ ions. (C) 2020 Elsevier B.V. All rights reserved. | Preethi, Jayaram; Vigneshwaran, Sivakumar; Karthikeyan, Perumal; Park, Chang Min; Meenakshi, Sankaran | Gandhigram Rural Inst, Dept Chem, Gandhigram Dindigul 624302, Tamil Nadu, India; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea | Vigneshwaran, Siva kumar/IST-9536-2023; Meenakshi, Sankaran/AAF-5748-2020; Park, Chang Min/CAA-8506-2022; Vigneshwaran, Sivakumar/AAE-6278-2022; Karthikeyan, Perumal/T-6719-2019 | 58909614400; 57207105576; 57207499412; 57209588953; 58099005900 | sankaranmeenakshi2014@gmail.com; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 159 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2020 | 6.953 | 6.1 | 0.93 | 2025-06-25 | 22 | 24 | Chitosan; Zirconium; Photodegradation; ZnO | AQUEOUS-SOLUTION; REMOVAL; CR(VI); ZNO; ADSORPTION; NANOCOMPOSITE; DEGRADATION; FLUORIDE; DYE | Chitosan; Photodegradation; Zirconium; ZnO | Catalysis; Chitosan; Chromium; Hydrogen-Ion Concentration; Light; Nanocomposites; Oxidation-Reduction; Photochemical Processes; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Time Factors; X-Ray Diffraction; Zinc Oxide; Zirconium; anion; chitosan; chromium; hexavalent chromium; unclassified drug; zinc oxide; zirconium; chitosan; chromium; chromium hexavalent ion; nanocomposite; zinc oxide; zirconium; zirconium oxide; adsorption; Article; concentration (parameter); diffuse reflectance spectroscopy; electron spin resonance; Fourier transform infrared spectroscopy; irradiation; light; pH; photocatalysis; reaction analysis; reduction (chemistry); surface property; thermogravimetry; X ray diffraction; catalysis; chemistry; infrared spectroscopy; oxidation reduction reaction; photochemistry; time factor; ultrastructure | English | 2020 | 2020-09-15 | 10.1016/j.ijbiomac.2020.04.268 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Non-toxic nano approach for wastewater treatment using Chlorella vulgaris exopolysaccharides immobilized in iron-magnetic nanoparticles | The current study, novel magnetic nano-composite particles (Fe3O4@EPS) were successfully synthesized via the co-precipitation of iron (III) chloride and iron (II) sulfate (Fe3O4 nanoparticles) with exopolysaccharides (EPS) derived from the microalga Chlorella vulgaris. The physico-chemical nature of the Fe3O4@EPS was investigated in depth. Transmission electron microscopy (TEM) results estimated the core-shell nature of Fe3O4@EPS aggregated inside the indistinctly layered EPS matrix to be 10-20 nm in size. Scanning electron microscopy-based energy dispersive spectral analysis indicated that elemental Fewas successfully loaded on to the EPS polymeric ion-exchanger at a rate of 63.3% by weight. FT-IR results demonstrated that Fe3O4 nanoparticles were successfully modified by the functional groups present in EPS. Fe3O4@EPS showed a highly magnetic nature at 5.0 emu/g. The XPS survey spectrum, which showed two major peaks at 724.1 and 710.2 eV revealed the elemental composition and electronic structure of Fe3O4 nanoparticles and Fe3O4@EPS. Furthermore, nutrient removal from wastewater was studied. Under optimum conditions (3.5 g/L of Fe3O4@EPS, pH 7.0 and 13 h of incubation) 91% of PO43- and 85% of NH4+ were effectively eliminated. These findings demonstrate the potential of Fe3O4@EPS for removing PO43- and NH4+ in wastewater treatment plants. (C) 2020 Published by Elsevier B.V. | Govarthanan, M.; Jeon, Chang-Hyun; Jeon, Yun-Hui; Kwon, Jong-Hee; Bae, Hyokwan; Kim, Woong | Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Gyeongsang Natl Univ, Inst Agr & Life Sci, Dept Food Sci & Technol, Jinju 52828, South Korea; Pusan Natl Univ, Dept Civil & Environm Engn, 63 Busandeahak Ro, Busan 46241, South Korea | Muthusamy, Govarthanan/C-1491-2014; Govarthanan, Muthusamy/C-1491-2014 | 54881927600; 57217491155; 57217490097; 55972283900; 58299012900; 55581636400 | elshine@knu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 162 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2020 | 6.953 | 6.1 | 3.8 | 2025-06-25 | 67 | 94 | Ammonia; Chlorella vulgaris; Exopolysaccharide; Fe3O4@EPS; Phosphate | OXIDE NANOPARTICLES; PHOSPHORUS REMOVAL; EFFICIENT REMOVAL; PHOSPHATE; BIOFILM; PRECIPITATION; REDUCTION; PARTICLES; RECOVERY; NITROGEN | Ammonia; Chlorella vulgaris; Exopolysaccharide; Fe<sub>3</sub>O<sub>4</sub>@EPS; Phosphate | Chlorella vulgaris; Magnetic Iron Oxide Nanoparticles; Polysaccharides; Waste Water; Water Pollutants, Chemical; Water Purification; exopolysaccharide; iron chloride nanoparticle; iron nanoparticle; iron sulfate nanoparticle; magnetic nanoparticle; unclassified drug; polysaccharide; algal growth; Article; chemical structure; Chlorella vulgaris; controlled study; energy dispersive X ray spectroscopy; Fourier transform infrared spectroscopy; incubation time; nonhuman; pH; physical chemistry; scanning electron microscopy; synthesis; transmission electron microscopy; waste water treatment plant; X ray photoemission spectroscopy; chemistry; Chlorella vulgaris; wastewater; water management; water pollutant | English | 2020 | 2020-11-01 | 10.1016/j.ijbiomac.2020.06.227 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Rheological properties of a neutral polysaccharide extracted from maca (Lepidium meyenii Walp.) roots with prebiotic and anti-inflammatory activities | The rheological, prebiotic, and anti-inflammatory properties of neutral polysaccharide extracted from maca roots (MP) were investigated. MP was composed of arabinose, galactose, rhamnose, and glucose. In steady shear rheological properties, an increasing concentration of MP solution exhibited higher apparent viscosity (eta(a,100)) and consistency index (K) under acidic condition (pH 4). In dynamic rheological properties, the dynamic moduli (G' and G '') in the frequency sweep test from the MP solution were increased with increasing concentration and decreasing pH. The changes in dynamic moduli of the MP solution with various concentrations and pH values were stable during 1 h storage at 4 degrees C due to the enhancement of hydrogen bonding. According to the results of the temperature sweep test, an increasing concentration of MP solution increased dynamic moduli under acidic conditions. The prebiotic properties of MP induced a higher growth of Bifidobacterium fongum ATCC15707 and Lactobacillus rhamnosus ATCC 7469 than inulin and increased acetic acid, propionic acid, and butyric acid more than inulin in vitro. Furthermore, MP inhibited lipopolysaccharide-induced NO production in RAW 264.7 cells, which indicated that an increasing concentration of MP enhanced anti-inflammatory activities. Therefore, MP is a potential functional material for the food and pharmaceutical industries. (C) 2020 Published by Elsevier B.V. | Lee, Yun-Kyung; Jung, Sung Keun; Chang, Yoon Hyuk | Kyung Hee Univ, Bionanocomposite Res Ctr, Dept Food & Nutr, Seoul 02447, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022; Chang, Yoon/AAH-6583-2019 | 54391355800; 35310491400; 36092517300 | yhchang@khu.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 152 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2020 | 6.953 | 6.1 | 1.74 | 2025-06-25 | 41 | 44 | Polysaccharide; Maca; Rheological properties; Prebiotic activity; Anti-inflammatory activity | WATER-SOLUBLE POLYSACCHARIDES; CHAIN FATTY-ACIDS; STRUCTURAL-CHARACTERIZATION; CONSTITUENTS; PURIFICATION | Anti-inflammatory activity; Maca; Polysaccharide; Prebiotic activity; Rheological properties | Animals; Anti-Inflammatory Agents; Cell Line; Hydrogen Bonding; Lepidium; Mice; Molecular Weight; Plant Extracts; Plant Roots; Polysaccharides; Prebiotics; RAW 264.7 Cells; Rheology; Viscosity; acetic acid; arabinose; butyric acid; galactose; glucose; inulin; Lepidium meyenii extract; polysaccharide; prebiotic agent; propionic acid; rhamnose; antiinflammatory agent; plant extract; polysaccharide; prebiotic agent; animal cell; antiinflammatory activity; Article; bacterial growth; Bifidobacterium longum; cell culture; cell viability; controlled study; drug purification; growth stimulation; hydrogen bond; in vitro study; Lactobacillus rhamnosus; mouse; nonhuman; plant root; RAW 264.7 cell line; viscosity; Western blotting; animal; cell line; chemistry; drug effect; flow kinetics; Lepidium; molecular weight; procedures | English | 2020 | 2020-06-01 | 10.1016/j.ijbiomac.2020.02.307 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Super-Resolution Three-Dimensional Imaging of Actin Filaments in Cultured Cells and the Brain via Expansion Microscopy | Actin is an essential protein in almost all life forms. It mediates diverse biological functions, ranging from controlling the shape of cells and cell movements to cargo transport and the formation of synaptic connections. Multiple diseases are closely related to the dysfunction of actin or actin-related proteins. Despite the biological importance of actin, super-resolution imaging of it in tissue is still challenging, as it forms very dense networks in almost all cells inside the tissue. In this work, we demonstrate multiplexed super-resolution volumetric imaging of actin in both cultured cells and mouse brain slices via expansion microscopy (ExM). By introducing a simple labeling process, which enables the anchoring of an actin probe, phalloidin, to a swellable hydrogel, the multiplexed ExM imaging of actin filaments was achieved. We first showed that this technique could visualize the nanoscale details of actin filament organizations in cultured cells. Then, we applied this technique to mouse brain slices and visualized diverse actin organizations, such as the parallel actin filaments along the long axis of dendrites and dense actin structures in postsynaptic spines. We examined the postsynaptic spines in the mouse brain and showed that the organizations of actin filaments are highly diverse. This technique, which enables the high-throughput 60 nm resolution imaging of actin filaments and other proteins in cultured cells and thick tissue slices, would be a useful tool to study the organization of actin filaments in diverse biological circumstances and how they change under pathological conditions. | Park, Chan E.; Cho, Youngbin; Cho, In; Jung, Hyunsu; Kim, Byeongyeon; Shin, Jennifer H.; Choi, Sungyoung; Kwon, Seok-Kyu; Hahn, Young Ki; Chang, Jae-Byum | Korea Adv Inst Sci & Technol, Dept Mat Sci & Engn, Daejeon 34141, South Korea; Korea Adv Inst Sci & Technol, Dept Mech Engn, Daejeon 34141, South Korea; Korea Univ, Div Life Sci, Seoul 02841, South Korea; Korea Inst Sci & Technol, Brain Sci Inst, Ctr Funct Connect, Seoul 02792, South Korea; Hanyang Univ, Dept Elect Engn, Seoul 04763, South Korea; Korea Univ Sci & Technol UST, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; Kyungpook Natl Univ, Ind Technol Adv, Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Korea Adv Inst Sci & Technol, KI Hlth Sci & Technol, Daejeon 34141, South Korea | Park, Chan/L-8485-2017; Chang, Jae-Byum/AAF-2790-2019 | 57833185000; 59181529900; 57202253119; 57213161198; 57044972700; 7402724017; 57209837667; 36786750600; 16052846700; 36086971400 | skkwon@kist.re.kr;hahnv79@gmail.com;jbchang03@kaist.ac.kr; | ACS NANO | ACS NANO | 1936-0851 | 1936-086X | 14 | 11 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 15.881 | 6.1 | 1.6 | 2025-06-25 | 26 | 26 | actin filament; expansion microscopy; super-resolution imaging; synapse; postsynaptic density | Actin filament; Expansion microscopy; Postsynaptic density; Super-resolution imaging; Synapse | Actin Cytoskeleton; Actins; Animals; Brain; Cells, Cultured; Imaging, Three-Dimensional; Mice; Microscopy; Cells; Cytology; Expansion; Optical resolving power; Tissue; Tissue engineering; actin; Actin organization; Actin-related proteins; Biological functions; Essential proteins; Pathological conditions; Super resolution imaging; Synaptic connections; Three dimensional imaging; actin filament; animal; brain; cell culture; diagnostic imaging; metabolism; microscopy; mouse; three-dimensional imaging; Proteins | English | 2020 | 2020-11-24 | 10.1021/acsnano.0c04915 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ultra-stiff compressed collagen for corneal perforation patch graft realized byin situphotochemical crosslinking | Despite the potential of a collagen construct, consisting of a major extracellular matrix component of the native cornea, as a patch graft to treat the corneal perforation, there has still been difficulty in acquiring sufficient mechanical properties for clinical availability. This study developed a novelin situphotochemical crosslinking (IPC)-assisted collagen compression process, namely, the IPC-C(2)process, to significantly enhance the mechanical properties of the collagen construct for the development of a collagenous patch graft. For the first time, we found that compressed collagen construct was rapidly rehydrated in an aqueous solution, which inhibited effective riboflavin-mediated photochemical crosslinking for mechanical improvement. The IPC-C(2)process was designed to concurrently induce the physical compaction and photochemical crosslinking of a compressed collagen construct, thereby avoiding the loosening of collagen fibrillar structure during rehydration and ultimately improving crosslinking efficiency. Hence, the suggested IPC-C(2)process could fabricate a collagen construct with a high collagen density (similar to 120-280 mg ml(-1)) and similar to 10(3)-fold increased mechanical properties (an elastic modulus of up to similar to 29 MPa and ultimate tensile strength of similar to 8 MPa) compared with collagen gel. This construct can then be used as a clinically applicable collagenous patch graft. With sufficient mechanical strength for surgical suture and the controllable thickness for patient specificity, the potential of the fabricated IPC-compressed collagen construct for clinical applications was demonstrated by using anin vivorabbit corneal perforation model. It effectively protected aqueous humor leakage and maintained the integrity of the eye globe without an additional complication. | Hong, Hyeonjun; Kim, Jeongho; Cho, Hoseong; Park, Sang Min; Jeon, Mansik; Kim, Hong Kyun; Kim, Dong Sung | Pohang Univ Sci & Technol POSTECH, Dept Mech Engn, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Sch Med, Dept Ophthalmol, Daegu 41944, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, Daegu 41566, South Korea; Kyungpook Natl Univ Hosp, Inst Biomed, Daegu 41944, South Korea; Pusan Natl Univ, Sch Mech Engn, 2,Busandaehak Ro 63beon Gil, Busan 46241, South Korea | Kim, Dong-Seong/AAI-9774-2021; Kim, Hong Kyun/ITT-7758-2023 | 57008620000; 57219385573; 57209416599; 57201909136; 24171094000; 57218260940; 55742938500 | smkds@postech.ac.kr; | BIOFABRICATION | BIOFABRICATION | 1758-5082 | 1758-5090 | 12 | 4 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2020 | 10.02 | 6.1 | 0.38 | 2025-06-25 | 7 | 8 | collagen compression process; photochemical crosslinking; mechanical properties; collagenous patch graft; corneal perforation | AMNIOTIC MEMBRANE TRANSPLANTATION; IN-VIVO; MECHANICAL-PROPERTIES; RIBOFLAVIN; MANAGEMENT; SCAFFOLD; CONSTRUCTS; LACERATION; HYDROGELS; MATRIX | Collagen compression process; Collagenous patch graft; Corneal perforation; Mechanical properties; Photochemical crosslinking | Animals; Collagen; Cornea; Corneal Perforation; Cross-Linking Reagents; Humans; Photochemical Processes; Rabbits; Riboflavin; Tensile Strength; Density (specific gravity); Tensile strength; collagen; cross linking reagent; riboflavin; Clinical application; Collagen constructs; Compression process; Extracellular matrix components; Fibrillar structures; Patient specificity; Photochemical cross-linking; Ultimate tensile strength; animal; cornea; cornea perforation; human; Leporidae; photochemistry; tensile strength; Collagen | English | 2020 | 2020-10 | 10.1088/1758-5090/abb52a | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Unveiling the potentials of bacteriocin (Pediocin L50) from Pediococcus acidilactici with antagonist spectrum in a Caenorhabditis elegans model | Human-milk-based probiotics play a major role in the early colonization and protection of infants against gastrointestinal infection. We investigated potential probiotics in human milk. Among 41 Lactic acid bacteria (LAB) strains, four strains showed high antimicrobial activity against Escherichia coli 0157:H7, Listeria monocytogenes ATCC 15313, Bacillus cereus ATCC 14576, Staphylococcus aureus ATCC 19095, and Helicobacter pylori. The selected LAB strains were tested in simulated gastrointestinal conditions for their survival. Four LAB strains showed high resistance to pepsin (82%-99%), bile with pancreatine stability (96%-100%), and low pH (80%-94%). They showed moderate cell surface hydrophobicity (22%-46%), auto-aggregation abilities (12%-34%), and 70%-80% co-aggregation abilities against L. monocytogenes ATCC 15313, S. aureus ATCC 19095, B. cereus ATCC 14576, and E. coli 0157:H7. All four selected isolates were resistant to gentamicin, imipenem, novobiocin, tetracycline, clindamycin, meropenem, ampicillin, and penicillin. The results show that Pediococcus acidilatici is likely an efficient probiotic strain to produce < 3 Kda pediocin-based antimicrobial peptides, confirmed by applying amino acid sequences), using liquid chromatography mass spectrometry and HPLC with the corresponding sequences from class 2 bacteriocin, and based on the molecular docking, the mode of action of pediocin was determined on LipoX complex, further the C-13 nuclear magnetic resonance structural analysis, which confirmed the antimicrobial peptide as pediocin. (C) 2019 Elsevier B.V. All rights reserved. | Chelliah, Ramachandran; Saravanakumar, Kandasamy; Daliri, Eric Banan-Mwine; Kim, Joong-Hark; Lee, Jung-Kun; Jo, Hyeon-yeong; Kim, Se-Hun; Ramakrishnan, Sudha Rani; Madar, Inamul Hasan; Wei, Shuai; Rubab, Momna; Barathikannan, Kaliyan; Ofosu, Fred Kwame; Subin, Hwang; Eun-ji, Park; Yeong, Jung Da; Elahi, Fazle; Wang, Myeong-Hyeon; Park, Jong Hwan; Ahn, Juhee; Kim, Dong-Hwan; Park, Sung Jin; Oh, Deog-Hwan | Kangwon Natl Univ, Coll Agr & Life Sci, Dept Food Sci & Biotechnol, Chunchon 24341, Gangwon Do, South Korea; Kangwon Natl Univ, Coll Biomed Sci, Dept Med Biotechnol, Chunchon 24341, Gangwon Do, South Korea; Erom Co Ltd, Chunchon 24427, Gangwon Do, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu, South Korea; Bharathidasan Univ, Sch Life Sci, Dept Biochem, Thiruchirappalli, Tamil Nadu, India; Guangdong Ocean Univ, Coll Food Sci & Technol, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Zhanjiang 524088, Peoples R China; Chonnam Natl Univ, Lab Anim Med, Gwangju, South Korea; Kangwon Natl Univ, Kangwon Inst Inclus Technol, Chunchon 24341, Gangwon Do, South Korea | Ghimire, Madhav/AAT-3026-2021; Madar, Inamul Hasan/F-5762-2010; Madar, Dr Inamul Hasan/F-5762-2010; Daliri, Eric Banan-Mwine/JQV-7944-2023; Kim, Yeon-Ju/AAE-5919-2019; wei, shuai/GUS-6394-2022; Ramakrishnan, Sudha/V-6342-2017; Oh, Deog-Hwan/AHE-4751-2022; BARATHIKANNAN, KALIYAN/U-3027-2019; Ahn, Juhee/G-1959-2014; Elahi, Fazle/AAW-2559-2020; Saravanakumar, Kandasamy/P-6745-2018 | 55954049700; 26028445100; 56483260100; 57209466404; 57212349833; 57200685458; 57195906431; 57190606907; 54793205900; 57189309239; 57200441377; 57190745599; 57217321594; 57212351528; 57212344120; 57212343157; 57213854802; 7406686297; 15838687800; 8208639500; 57211539057; 57191673193; 7203001812 | deoghwa@kangwon.ac.kr; | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | INT J BIOL MACROMOL | 0141-8130 | 1879-0003 | 143 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CHEMISTRY, APPLIED;POLYMER SCIENCE | 2020 | 6.953 | 6.1 | 0.75 | 2025-06-25 | 17 | 17 | Probiotic; Pediococcus acidilatici; Antimicrobial peptide (pediocin); C-13 NMR; LCMS | LACTIC-ACID BACTERIA; IN-VITRO; ANTIMICROBIAL PEPTIDES; ANTIBIOTIC-RESISTANCE; BREAST-MILK; INHIBITORY PEPTIDES; PROBIOTICS; LACTOBACILLUS; IDENTIFICATION; STRAINS | <sup>13</sup>C NMR; Antimicrobial peptide (pediocin); LCMS; Pediococcus acidilatici; Probiotic | Animals; Anti-Bacterial Agents; Bacterial Infections; Caenorhabditis elegans; Pediocins; Pediococcus acidilactici; Probiotics; ampicillin; clindamycin; gentamicin; imipenem; meropenem; novobiocin; pediocin; penicillin derivative; pepsin A; probiotic agent; tetracycline; antiinfective agent; pediocin; probiotic agent; animal cell; antibiotic resistance; antibiotic sensitivity; Article; Bacillus cereus; bacterial strain; bacterium isolate; Caenorhabditis elegans; carbon nuclear magnetic resonance; controlled study; cytotoxicity; cytotoxicity test; Escherichia coli; female; Helicobacter pylori; high performance liquid chromatography; human; human tissue; hydrophobicity; in vitro study; intestine flora; liquid chromatography-mass spectrometry; Listeria monocytogenes; molecular docking; mouse; NIH 3T3 cell line; nonhuman; nuclear magnetic resonance; Pediococcus acidilactici; pH; Staphylococcus aureus; structure analysis; animal; bacterial infection; Caenorhabditis elegans; chemistry; microbiology; Pediococcus acidilactici | English | 2020 | 2020-01-15 | 10.1016/j.ijbiomac.2019.10.196 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Defining the thermal sensitivity (Griffiths constant) of building occupants in the Korean residential context | Griffiths method is a widely used to estimate the comfort temperature of occupants. Although 0.5/K has been widely used as the representative thermal sensitivity (Griffiths constant) on various building types, this value was derived mainly from office data relying on assumptions that have not been fully field-validated (i.e., the assumption of no adaptive behavior occurring during the day). With an aim to empirically derive the thermal sensitivity (Griffiths constant) of occupants in residential settings, field monitoring was conducted in eleven households in South Korea. Within each household, physical indoor environmental data, subjective data and occupant behavioral data were recorded at 5 min intervals (from 8 a.m. to 8 p.m.). The value of the resulting regression coefficient (b) between the indoor temperature and the thermal sensation of occupants was estimated to be 0.356/K. This result indicates that the thermal sensation of the occupants of residential buildings is less sensitive to indoor temperature changes compared to that of occupants of other building types (e.g. offices 0.5/K). To increase the reliability of future thermal comfort research, the thermal sensitivity should reflect the characteristics of the building in question, rather than applying uncritically a generalized, universal Griffiths Constant such as 0.5/K. (C) 2019 Elsevier B.V. All rights reserved. | Ryu, Jihye; Kim, Jungsoo; Hong, Wonhwa; de Dear, Richard | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea; Univ Sydney, Sch Architecture Design & Planning, Sydney, NSW 2006, Australia | de Dear, Richard/AAP-8963-2020; Kim, Jungsoo/GQB-1511-2022; de Dear, Richard/HLQ-1063-2023 | 56192651000; 57189969323; 7401527968; 57509153500 | ryou0407@knu.ac.kr;jungsoo.kim@sydney.edu.au;hongwh@knu.ac.kr;richard.dedear@sydney.edu.au; | ENERGY AND BUILDINGS | ENERG BUILDINGS | 0378-7788 | 1872-6178 | 208 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENERGY & FUELS;ENGINEERING, CIVIL | 2020 | 5.879 | 6.2 | 2.25 | 2025-06-25 | 36 | 41 | Adaptive thermal comfort; Occupant; Thermal sensitivity; Griffiths constant; Residential buildings | NATURALLY VENTILATED BUILDINGS; COMPOSITE CLIMATE; COMFORT TEMPERATURE; ADAPTIVE-BEHAVIOR; OFFICES; MODEL; PRODUCTIVITY; ADAPTATION; CHANGSHA; HOMES | Adaptive thermal comfort; Griffiths constant; Occupant; Residential buildings; Thermal sensitivity | Space heating; Thermal comfort; Adaptive thermal comfort; Griffiths constant; Occupant; Residential building; Thermal sensitivity; Housing | English | 2020 | 2020-02-01 | 10.1016/j.enbuild.2019.109648 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hemodialysis with Cohort Isolation to Prevent Secondary Transmission during a COVID-19 Outbreak in Korea | Significance Statement Health care?associated infections during previous serious coronavirus epidemics resulted from human-to-human transmission in hemodialysis (HD) facilities. The authors analyzed the effect of a strategy of HD with cohort isolation on the secondary transmission of coronavirus disease 2019 (COVID-19) in HD facilities in Korea, which involves administering an immediate screening test for COVID-19 to all close contacts (patients on HD and health care workers) and strict maintenance of cohort isolation. Epidemiologic investigation and immediate screening tests across 11 HD centers identified 302 close contacts. HD with cohort isolation was maintained for a median of 14 days, and the transmission rate was 0.66% inside HD units. Clinical practice guidelines for HD with cohort isolation during COVID-19 outbreaks may successfully prevent secondary transmission through HD units. Background Health care?associated infections during previous coronavirus epidemics involving severe acute respiratory syndrome and Middle East respiratory syndrome resulted from human-to-human transmission in hemodialysis (HD) facilities. The effect of a strategy of HD with cohort isolation?separate dialysis sessions for close contacts of patients with confirmed coronavirus disease 2019 (COVID-19)?on the prevention of secondary transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in HD units is unknown. Methods Our multicenter cohort study of an HD with cohort isolation strategy enrolled close contacts of patients with confirmed COVID-19, including patients on HD and health care workers in HD units. Close contacts had been identified by epidemiologic investigation and tested negative on an immediate screening test for SARS-CoV-2. Results As of March 14, 11 patients on HD and 7 health care workers from 11 HD centers were diagnosed as having COVID-19. The immediate screening test was performed in 306 people, and among them, 302 close contacts with negative test results were enrolled. HD with cohort isolation was performed among all close contacts for a median of 14 days in seven centers. During cohort isolation, nine patients showed symptoms but tested negative for SARS-CoV-2. Two health care workers in the HD units (0.66% of the total group) were diagnosed at the termination test for SARS-CoV-2. Conclusions The transmission of COVID-19 can be controlled without closure of HD centers by implementing preemptive activities, including early detection with rapid testing, cohort isolation, collaboration between institutions, and continuous monitoring of infection. Our strategy and experience may provide helpful guidance for circumstances involving the rapid spread of infectious diseases such as COVID-19. | Cho, Jang-Hee; Kang, Seok Hui; Park, Hayne Cho; Kim, Dong Ki; Lee, Sang-Ho; Do, Jun Young; Park, Jong Won; Kim, Seong Nam; Kim, Myeong Seong; Jin, Kyubok; Kang, Gun Woo; Park, Sun-Hee; Kim, Yong-Lim; Lee, Young-Ki | Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea; Yeungnam Univ Hosp, Dept Internal Med, Daegu, South Korea; Hallym Univ, Coll Med, Hallym Kidney Res Inst, Dept Internal Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Kyung Hee Univ Hosp Gangdong, Dept Internal Med, Seoul, South Korea; Kim Seong Nam Internal Med Clin, Dept Internal Med, Seoul, South Korea; Gojan Myeong Internal Med Clin, Dept Internal Med, Ansan, South Korea; Keimyung Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Dept Internal Med, Daegu, South Korea | Cho, Jang-hee/ABD-3534-2020; Kim, Yong-Lim/AGK-3172-2022; Kim, Dong Ki/J-5389-2012; Park, Sun-Hee/LMN-0033-2024 | 7403536291; 35269232600; 34771965700; 23479259100; 58993694600; 7006754007; 54955660800; 37031276200; 57217653573; 55050687400; 55667619200; 7501831741; 55633533600; 55716130600; 8323814700; 59109873500; 58598910200; 35314863200; 55890136000; 57737628900; 59102634200; 59075322000; 59110094800; 7410205767; 58368657300 | km2071@naver.com; | JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | J AM SOC NEPHROL | 1046-6673 | 1533-3450 | 31 | 7 | SCIE | UROLOGY & NEPHROLOGY | 2020 | 10.121 | 6.2 | 2.55 | 2025-06-25 | 30 | 34 | coronavirus; hemodialysis units; end-stage renal disease; quarantine; cohort isolation; COVID-19 | ACUTE RESPIRATORY SYNDROME; CLINICAL CHARACTERISTICS | Adult; Chi-Square Distribution; Cohort Studies; Comorbidity; Coronavirus Infections; Disease Outbreaks; Disease Transmission, Infectious; Female; Health Personnel; Humans; Incidence; Infection Control; Kidney Failure, Chronic; Male; Middle Aged; Occupational Health; Pandemics; Patient Isolation; Patient Safety; Pneumonia, Viral; Program Evaluation; Renal Dialysis; Republic of Korea; Retrospective Studies; Risk Assessment; Secondary Prevention; Statistics, Nonparametric; Survival Rate; adult; Article; clinical article; cohort analysis; controlled study; coronavirus disease 2019; epidemic; female; health care organization; health care personnel; hemodialysis; hemodialysis patient; human; infection prevention; laboratory test; male; null result; patient isolation; practice guideline; priority journal; screening test; secondary infection; Severe acute respiratory syndrome coronavirus 2; South Korea; virus transmission; chi square distribution; chronic kidney failure; clinical trial; comorbidity; Coronavirus infection; disease transmission; epidemic; hemodialysis; incidence; infection control; middle aged; multicenter study; nonparametric test; occupational health; organization and management; pandemic; patient isolation; patient safety; prevention and control; procedures; program evaluation; retrospective study; risk assessment; secondary prevention; survival rate; virus pneumonia | English | 2020 | 2020-07 | 10.1681/asn.2020040461 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | MYB81, a microspore-specific GAMYB transcription factor, promotes pollen mitosis I and cell lineage formation in Arabidopsis | Sexual reproduction in flowering plants relies on the production of haploid gametophytes that consist of germline and supporting cells. During male gametophyte development, the asymmetric mitotic division of an undetermined unicellular microspore segregates these two cell lineages. To explore genetic regulation underlying this process, we screened for pollen cell patterning mutants and isolated the heterozygous myb81-1 mutant that sheds similar to 50% abnormal pollen. Typically, myb81-1 microspores fail to undergo pollen mitosis I (PMI) and arrest at polarized stage with a single central vacuole. Although most myb81-1 microspores degenerate without division, a small fraction divides at later stages and fails to acquire correct cell fates. The myb81-1 allele is transmitted normally through the female, but rarely through pollen. We show that myb81-1 phenotypes result from impaired function of the GAMYB transcription factor MYB81. The MYB81 promoter shows microspore-specific activity and a MYB81-RFP fusion protein is only expressed in a narrow window prior to PMI. Ectopic expression of MYB81 driven by various promoters can severely impair vegetative or reproductive development, reflecting the strict microspore-specific control of MYB81. Our data demonstrate that MYB81 has a key role in the developmental progression of microspores, enabling formation of the two male cell lineages that are essential for sexual reproduction in Arabidopsis. | Oh, Sung-Aeong; Thuong Nguyen Thi Hoai; Park, Hyo-Jin; Zhao, Mingmin; Twell, David; Honys, David; Park, Soon-Ki | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Univ Leicester, Dept Genet & Genome Biol, Univ Rd, Leicester LE1 7RH, Leics, England; Czech Acad Sci, Inst Expt Bot, Lab Pollen Biol, Vvi, Prague, Czech Republic | ; Honys, David/I-6707-2013; Twell, David/D-8043-2011 | 7404104444; 57211945817; 57195461725; 57204978607; 7004821730; 56084847600; 8055974900 | psk@knu.ac.kr; | PLANT JOURNAL | PLANT J | 0960-7412 | 1365-313X | 101 | 3 | SCIE | PLANT SCIENCES | 2020 | 6.486 | 6.2 | 0.83 | 2025-06-25 | 23 | 20 | Arabidopsis; MYB81; microspore; pollen mitosis I; transcription factor; vacuole | MICROTUBULE ORGANIZATION; SIDECAR-POLLEN; GENE-EXPRESSION; DIVISION; PROLIFERATION; PROTEIN; AUGMIN; FAMILY; DIFFERENTIATION; IDENTIFICATION | Arabidopsis; microspore; MYB81; pollen mitosis I; transcription factor; vacuole | Cell Division; Cytology; Development; Formation; Plants; Pollen; Proteins; Reproduction; Arabidopsis; Arabidopsis Proteins; Cell Lineage; Haploidy; Mitosis; Phenotype; Pollen; Transcription Factors; Cell proliferation; Cytology; Proteins; Transcription; Transcription factors; Arabidopsis protein; transcription factor; Arabidopsis; microspore; MYB81; Pollen mitosis i; vacuole; Arabidopsis; cell lineage; genetics; haploidy; metabolism; mitosis; phenotype; physiology; pollen; Plants (botany) | English | 2020 | 2020-02 | 10.1111/tpj.14564 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Quantifying householder tolerance of thermal discomfort before turning on air-conditioner | In order to achieve comfort, or to remove discomfort, building occupants constantly interact with the indoor environment through various adaptive behaviors. The purpose of this study is to better understand the adaptive thermal comfort mechanisms by investigating the interrelationship between the indoor thermal environments, the expectation of the occupants, and their behavioral adjustments in residential contexts. Eleven households in South Korea participated in our field experiments performed during summer months (June, July and August) between 2015 and 2017. The indoor thermal environmental parameters, occupants' subjective evaluations of thermal comfort, and their operational patterns of air-conditioners were monitored simultaneously. On average 1512 datasets from each participating household and a total of 16,632 datasets were collected and analyzed. Our analysis focused on understanding both the temporal dimension (i.e. duration of thermal discomfort episodes) and the intensity of stimuli (i.e. deviation from the comfort zone) both before- and after the participants' decision on the use of air-conditioners. The study proposes the constructs of 'discomfort capacity' and 'comfort restoration' as multi-dimensional indices to better understand the triggering mechanisms for household air-conditioner usage. Using these indices, the study quantified householders' tolerance of thermal discomfort events before they resort to air-conditioning. The findings have practical implications in setting up dynamic control strategies that are more responsive to occupant real-time comfort demands. (C) 2020 Elsevier B.V. All rights reserved. | Ryu, Jihye; Kim, Jungsoo; Hong, Wonhwa; de Dear, Richard | Kyungpook Natl Univ, Sch Architectural Civil Environm & Energy Engn, Daegu 41566, South Korea; Univ Sydney, Sch Architecture Design & Planning, Sydney, NSW 2006, Australia | de Dear, Richard/HLQ-1063-2023; de Dear, Richard/AAP-8963-2020; Kim, Jungsoo/GQB-1511-2022 | 56192651000; 57189969323; 7401527968; 57509153500 | jungsoo.kim@sydney.edu.au; | ENERGY AND BUILDINGS | ENERG BUILDINGS | 0378-7788 | 1872-6178 | 211 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENERGY & FUELS;ENGINEERING, CIVIL | 2020 | 5.879 | 6.2 | 1.13 | 2025-06-25 | 23 | 22 | Occupant; Thermal comfort; Control; HVAC system; Adaptive behavior; Residential buildings | COOLING DEGREE-HOURS; ADAPTIVE COMFORT; RESIDENTIAL BUILDINGS; PERCEIVED CONTROL; ADAPTATION; INDOOR; TEMPERATURE; BEHAVIOR; CLIMATE; MODEL | Adaptive behavior; Control; HVAC system; Occupant; Residential buildings; Thermal comfort | Adaptive control systems; Control engineering; Domestic appliances; Housing; Thermal comfort; Adaptive behavior; Adaptive thermal comfort; Environmental parameter; HVAC system; Indoor thermal environments; Occupant; Residential building; Subjective evaluations; Air conditioning | English | 2020 | 2020-03-15 | 10.1016/j.enbuild.2020.109797 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Acetylated K676 TGFBIp as a severity diagnostic blood biomarker for SARS-CoV-2 pneumonia | The outbreak of the highly contagious and deadly severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as coronavirus disease 2019 (COVID-19), has posed a serious threat to public health across the globe, calling for the development of effective diagnostic markers and therapeutics. Here, we report a highly reliable severity diagnostic biomarker, acetylated 676th lysine transforming growth factor-beta-induced protein (TGFBIp K676Ac). TGFBIp K676Ac was consistently elevated in the blood of patients with SARS-CoV-2 pneumonia (n = 113), especially in patients in the intensive care unit (ICU) compared to non-ICU patients. Patients' blood samples showed increased cytokines and lymphopenia, which are exemplary indicators of SARS-CoV-2 pneumonia. Treatment with TGFBIp neutralizing antibodies suppressed the cytokine storm. The increased level of TGFBIp K676Ac in ICU patients suggests the promise of this protein as a reliable severity diagnostic biomarker for severe SARS-CoV-2 disease. | Park, Hee Ho; Kim, Hong Nam; Kim, Hyelim; Yoo, Youngbum; Shin, Hyosoo; Choi, Eun Young; Bae, Jong-Sup; Lee, Wonhwa | Kangwon Natl Univ, Dept Biotechnol & Bioengn, Chunchon 24341, Gangwon Do, South Korea; Korea Inst Sci & Technol KIST, Brain Sci Inst, Ctr BioMicrosyst, Seoul 02792, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea; Yeungnam Univ, Yeungnam Univ Med Ctr, Coll Med, Dept Internal Med, Daegu 42415, South Korea; Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multi Based Creat Drug Res Team, CMRI,Res Inst Pharmaceut Sci, Daegu 41566, South Korea | Lee, Wonhwa/GLQ-6506-2022; Kim, Hong/D-2922-2015; Kim, Hong Nam/D-2922-2015; Bae, Jong-Sup/AAU-9724-2020 | 25029802100; 35205791200; 57210146478; 57204017274; 57218711481; 57190418295; 16021543200; 50161632800 | letact@hanmail.net;baejs@knu.ac.kr;wonhwalee@kribb.re.kr; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 6 | 31 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 14.143 | 6.3 | 0.77 | 2025-06-25 | 19 | 19 | CYTOKINE STORM; COVID-19; ACTIVATION; PROTEIN; WUHAN | Acetylation; Antibodies, Neutralizing; Betacoronavirus; Biomarkers; Case-Control Studies; Coronavirus Infections; Cytokine Release Syndrome; Extracellular Matrix Proteins; Gene Expression; Humans; Intensive Care Units; Leukocyte Count; Leukocytes, Mononuclear; Lung; Lysine; NF-kappa B; Pandemics; Pneumonia, Viral; Primary Cell Culture; Prognosis; Protein Processing, Post-Translational; Respiratory Insufficiency; Severity of Illness Index; Transforming Growth Factor beta; Amino acids; Biomarkers; Blood; Diseases; Health risks; Intensive care units; Proteins; betaIG-H3 protein; biological marker; immunoglobulin enhancer binding protein; lysine; neutralizing antibody; scleroprotein; transforming growth factor beta; Blood samples; Coronaviruses; Diagnostic biomarkers; Diagnostic markers; Induced proteins; Neutralizing antibodies; Severe acute respiratory syndrome coronavirus; Transforming growth factors; acetylation; Betacoronavirus; blood; case control study; Coronavirus infection; cytokine release syndrome; drug effect; gene expression; genetics; human; immunology; intensive care unit; leukocyte count; lung; metabolism; mononuclear cell; pandemic; pathogenicity; pathology; primary cell culture; prognosis; protein processing; respiratory failure; severity of illness index; vascularization; virology; virus pneumonia; Diagnosis | English | 2020 | 2020-07 | 10.1126/sciadv.abc1564 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | BDNF-induced local translation of GluA1 is regulated by HNRNP A2/B1 | The AMPA receptor subunit GluA1 is essential for induction of synaptic plasticity. While various regulatory mechanisms of AMPA receptor expression have been identified, the underlying mechanisms of GluA1 protein synthesis are not fully understood. In neurons, axonal and dendritic mRNAs have been reported to be translated in a capin-dependent manner. However, molecular mechanisms of cap-independent translation of synaptic mRNAs remain largely unknown. Here, we show that GluA1 mRNA contains an internal ribosome entry site (IRES) in the 5'UTR. We also demonstrate that heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 interacts with GuAl mRNA and mediates internal initiation of GluA1. Brain-derived neurotrophic factor (BDNF) stimulation increases IRES-mediated GuA1 translation via up-regulation of HNRNP A2/B1. Moreover, BDNF-induced GluA1 expression and dendritic spine density were significantly decreased in neurons lacking hnRNP A2/B1. Together, our data demonstrate that IRES-mediated translation of GluA1 mRNA is a previously unidentified feature of local expression of the AMPA receptor. | Jung, Youngseob; Seo, Ji-Young; Ryu, Hye Guk; Kim, Do-Yeon; Lee, Kyung-Ha; Kim, Kyong-Tai | Pohang Univ Sci & Technol, Div Integrat Biosci & Biotechnol, Pohang 37673, Gyeongbuk, South Korea; Pohang Univ Sci & Technol, Dept Life Sci, Pohang 37673, Gyeongbuk, South Korea; Kyungpook Natl Univ, Sch Dent, Brain Sci & Engn Inst, Dept Pharmacol, Daegu 41940, South Korea; Daegu Haany Univ, Div Cosmet Sci & Technol, Gyeongbuk 38610, South Korea; Yale Univ, Sch Med, Dept Genet, New Haven, CT 06510 USA | ; Park, Mi-Kyung/J-9643-2017; Kim, Do-Yeon/AET-3021-2022; Lee, Kyung-Ha/GRY-2640-2022 | 56123237500; 57188750232; 56611282900; 57203012542; 54967786000; 7409315595 | ktk@postech.ac.kr; | SCIENCE ADVANCES | SCI ADV | 2375-2548 | 6 | 47 | SCIE | MULTIDISCIPLINARY SCIENCES | 2020 | 14.143 | 6.3 | 0.68 | 2025-06-25 | 15 | 15 | PROTEIN-SYNTHESIS; INTERNAL INITIATION; SYNAPTIC PLASTICITY; AMPA RECEPTORS; VISUALIZATION; TRAFFICKING | Biosynthesis; Brain-derived neurotrophic factors; Cap-independent translation; Heterogeneous nuclear ribonucleoprotein (hnRNP); Internal ribosome entry site; Molecular mechanism; Protein synthesis; Regulatory mechanism; Synaptic plasticity; Neurons | English | 2020 | 2020-11 | 10.1126/sciadv.abd2163 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Direct observation of rewetting failure mechanism at CHF under different subcooled flows | In this study, we visualized vertical upward flow boiling under different subcooling conditions to identify dry patch behaviors. Shadowgraph visualizations and total internal reflection images were synchronized to capture the bubble structure and dry patch behaviors. A 12-cm-long indium tin oxide film heater coated with 0.5-mm-thick sapphire was used for the experiments. Under all subcooling conditions, we observed a significant retardation of the rewetting momentum when large elongated bubbles and dry patches were generated. Before CHF triggering, the dry patch size reached its maximum value and rewetting was delayed, thereby leading to an increase in the dry patch lifetime. We also investigated the relationship between the maximum size and lifetime of irreversible dry patches under different subcooling conditions and determined the reason for the significant increase in the lifetime of the irreversible dry patch. (C) 2020 Elsevier Ltd. All rights reserved. | Choi, Moonhee; Chu, In-Cheol; Kim, Seolha; Jeon, ByongGuk; Jo, HangJin | POSTECH, Div Adv Nucl Engn, Pohang 37673, South Korea; POSTECH, Mech Engn, Pohang 37673, South Korea; Korea Atom Energy Res Inst, Daejeon 34057, South Korea; Kyungpook Natl Univ, Dept Precis Mech Engn, Sangju 37224, South Korea | 57202256705; 7103327485; 57195257413; 15076792600; 58184830400 | jhj04@postech.ac.kr; | INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER | INT J HEAT MASS TRAN | 0017-9310 | 1879-2189 | 163 | SCIE | ENGINEERING, MECHANICAL;MECHANICS;THERMODYNAMICS | 2020 | 5.584 | 6.3 | 0.35 | 2025-06-25 | 6 | 8 | Critical heat flux; Dry patch; Flow boiling; Subcooling condition | CRITICAL HEAT-FLUX; POOL; MODEL | Critical heat flux; Dry patch; Flow boiling; Subcooling condition | Cooling; Oxide films; Refractive index; Sapphire; Tin oxides; Bubble structures; Direct observations; Failure mechanism; Indium Tin Oxide films; Shadowgraph visualization; Subcooled flow; Total internal reflections; Vertical upward flows; Failure (mechanical) | English | 2020 | 2020-12 | 10.1016/j.ijheatmasstransfer.2020.120465 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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