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○ | ○ | Article | CytoPAN-Portable cellular analyses for rapid point-of-care cancer diagnosis | Rapid, automated, point-of-care cellular diagnosis of cancer remains difficult in remote settings due to lack of specialists and medical infrastructure. To address the need for same-day diagnosis, we developed an automated image cytometry system (CytoPAN) that allows rapid breast cancer diagnosis of scant cellular specimens obtained by fine needle aspiration (FNA) of palpable mass lesions. The system is devoid of moving parts for stable operations, harnesses optimized antibody kits for multiplexed analysis, and offers a user-friendly interface with automated analysis for rapid diagnoses. Through extensive optimization and validation using cell lines and mouse models, we established breast cancer diagnosis and receptor subtyping in 1 hour using as few as 50 harvested cells. In a prospective patient cohort study (n = 68), we showed that the diagnostic accuracy was 100% for cancer detection and the receptor subtyping accuracy was 96% for human epidermal growth factor receptor 2 and 93% for hormonal receptors (ER/PR), two key biomarkers associated with breast cancer. A combination of FNA and CytoPAN offers faster, less invasive cancer diagnoses than the current standard (core biopsy and histopathology). This approach should enable the ability to more rapidly diagnose breast cancer in global and remote settings. | Min, Jouha; Chin, Lip Ket; Oh, Juhyun; Landeros, Christian; Vinegoni, Claudio; Lee, Jeeyeon; Lee, Soo Jung; Park, Jee Young; Liu, Ai-Qun; Castro, Cesar M.; Lee, Hakho; Im, Hyungsoon; Weissleder, Ralph | Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA; Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore; MIT, Harvard MIT Program Hlth Sci & Technol, 77 Massachusetts Ave, Cambridge, MA 02139 USA; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Surg, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Oncol Hematol, Daegu 41404, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41404, South Korea; Massachusetts Gen Hosp, Canc Ctr, Boston, MA 02114 USA; Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA; Harvard Med Sch, Dept Syst Biol, Boston, MA 02115 USA | Chin, Lip Ket/AAT-1535-2020; Lee, Hakho/M-9004-2016; Park, Jung Hwan/AAA-1951-2022; Liu, Aiqun/A-5066-2011; Lee, Jong-Mok/KVY-9550-2024; Vinegoni, Claudio/A-9490-2012; Im, Hyungsoon/IVU-8212-2023 | 55975937900; 55850856700; 57204633892; 55440518100; 6603697597; 37079213100; 57203597252; 57226185359; 7402583739; 37086975700; 35725732800; 57209766429; 35452687500 | hlee@mgh.harvard.edu;im.hyungsoon@mgh.harvard.edu;rweissleder@mgh.harvard.edu; | SCIENCE TRANSLATIONAL MEDICINE | SCI TRANSL MED | 1946-6234 | 1946-6242 | 12 | 555 | SCIE | CELL BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2020 | 17.992 | 1.1 | 1.43 | 2025-06-25 | 24 | 22 | LABEL-FREE DETECTION; HIV-INFECTION; BREAST; CELLS; BIOSENSORS; SPECIMENS | Biopsy, Fine-Needle; Breast Neoplasms; Female; Humans; Point-of-Care Systems; Prospective Studies; Sensitivity and Specificity; epidermal growth factor receptor 2; estrogen receptor; progesterone receptor; animal cell; animal experiment; animal model; Article; automation; breast cancer; breast cancer cell line; cancer diagnosis; cancer patient; cancer surgery; cohort analysis; controlled study; diagnostic accuracy; disease association; female; fine needle aspiration biopsy; gold standard; histopathology; human; human cell; major clinical study; mouse; nonhuman; point of care testing; preoperative period; priority journal; prospective study; tumor biopsy; breast tumor; point of care system; sensitivity and specificity | English | 2020 | 2020-08-05 | 10.1126/scitranslmed.aaz9746 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Numerical investigation of thermal and hydraulic characteristics of sCO2-water printed circuit heat exchangers with zigzag channels | Since the precooler and the recuperator are the largest components of a supercritical carbon dioxide Brayton cycle, their design can substantially affect the performance and size of the whole system. Although the design of a precooler with zigzag channel geometry as an alternative to straight channels can reduce its size significantly, the applicability of available correlations (e.g. 0.7 < Pr < 2.2) for the zigzag channel geometries is limited to the operational range of recuperators only. The current study, therefore, aims to develop correlations and understating of the complex flow and heat transfer characteristics in the zigzag channel printed circuit heat exchangers (PCHEs) operating under precooler conditions (2.2 < Pr < 13) of supercritical carbon dioxide Brayton cycle(sCO(2) -BC). Thermal and hydraulic characteristics of the PCHEs are computed numerically for a wide range of Reynolds numbers (5000 < Re < 7000) and Prandtl number (2.2 < Pr < 13). Also, a new data reduction method based on segmental averaged values has been proposed to handle adverse variations in the thermophysical properties of CO2 under precooler conditions. To ensure accurate evaluations, steep variations in the thermophysical properties of CO2 are implemented by supplying high-resolution real gas (RGP) property tables. Results suggest that thermal and hydraulic characteristics associated with zigzag channel vary substantially along the length of heat exchanger thus the conventional data reduction methods based on the channel average values cannot be used for true evaluations. Instead, segmental average values are used to develop pressure drop and heat transfer correlations for a broader range of Reynolds number and Prandtl number. The proposed correlations should be useful in the design of compact heat exchanger systems using zigzag channels for a wider range of cooling loads. | Saeed, Muhammad; Berrouk, Abdallah S.; Siddiqui, M. Salman; Awais, Ahmad Ali | Khalifa Univ Sci & Technol, Mech Engn Dept, Sas Al Nakhl Campus,POB 127788, Abu Dhabi, U Arab Emirates; Khalifa Univ Sci & Technol, Ctr Catalysis & Separat CeCas, POB 127788, Abu Dhabi, U Arab Emirates; Norwegian Univ Sci & Technol, Dept Architecture & Technol, Trondheim, Norway; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea | ; Saeed, Muhammad/R-4401-2019; Siddiqui, MuhammadSalman/LCT-4944-2024 | 56513270400; 15750216900; 56426764200; 57218293222 | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 224 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2020 | 9.709 | 1.1 | 2.98 | 2025-06-25 | 68 | 70 | Precooler design; Printed circuit heat exchanger; Pressure drop correlations; Heat transfer correlations | PERFORMANCE ANALYSIS; DESIGN OPTIMIZATION; POWER-GENERATION; MASS-TRANSFER; CO2; TURBINE; CYCLES; SIMULATION; AIRFOIL; STRAIGHT | Heat transfer correlations; Precooler design; Pressure drop correlations; Printed circuit heat exchanger | Brayton cycle; Buoyancy; Carbon dioxide; Cooling systems; Data reduction; Prandtl number; Printed circuits; Recuperators; Reynolds number; Supercritical fluid extraction; Thermodynamic properties; Timing circuits; Compact heat exchanger; Heat transfer correlation; Hydraulic characteristic; Numerical investigations; Operational range; Printed circuit heat exchangers; Reduction method; Supercritical carbon dioxides; Heat exchangers | English | 2020 | 2020-11-15 | 10.1016/j.enconman.2020.113375 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Performance analysis of carbon dioxide based combined power cycle for concentrating solar power | A detailed analysis of a combined power block system using carbon dioxide integrated with a thermal energy storage system and solar field is presented. The combined power block system consists of a topping supercritical carbon dioxide recompression Brayton cycle and its waste heat is recovered by coupling a bottoming transcritical carbon dioxide power cycle. Transcritical carbon dioxide power cycle is selected owing to its temperature glide merit and better heat transfer characteristics than conventional waste heat recovery cycle systems using other working fluids. A molten salt that can operate at relatively higher temperature than nitrate solar salt is selected as a storage medium and as heat transfer fluid between thermal energy storage system and external heat exchanger of power block. A complete mathematical model for the heliostat field, solar receiver, thermal energy storage, and power block system has been developed. The discretized heat exchanger approach has been implemented to accurately capture the properties of working fluid and to provide more refined results. Theoretical analysis of the system includes first and second law efficiencies and power output. The research findings suggest that the integrated combined cycle configuration is a promising alternative for efficient energy conversion and the established framework provides a profoundly potential way to utilize concentrated solar power. | Khatoon, Saboora; Kim, Man-Hoe | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, IEDT, Daegu 41566, South Korea | 57197833125; 55686310000 | manhoe.kim@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 205 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2020 | 9.709 | 1.1 | 2.44 | 2025-06-25 | 47 | 53 | Carbon dioxide; Combined cycle; Concentrated solar power; Thermal energy storage; Efficiency | SUPERCRITICAL CO2 RECOMPRESSION; ORGANIC RANKINE-CYCLE; BRAYTON CYCLE; EXERGOECONOMIC ANALYSES; OPTIMIZATION; ENERGY; DESIGN; TOWER; GENERATION; RECOVERY | Carbon dioxide; Combined cycle; Concentrated solar power; Efficiency; Thermal energy storage | Brayton cycle; Efficiency; Energy conversion; Heat exchangers; Heat storage; Heat transfer; Solar energy; Supercritical fluid extraction; Thermal energy; Waste heat; Waste heat utilization; Working fluids; Combined cycle; Concentrated solar power; Concentrating solar power; Heat transfer characteristics; Integrated combined cycles; Supercritical carbon dioxides; Thermal energy storage systems; Transcritical carbon dioxide; Carbon dioxide | English | 2020 | 2020-02-01 | 10.1016/j.enconman.2019.112416 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Predicting Endovascular Treatment Outcomes in Acute Vertebrobasilar Artery Occlusion: A Model to Aid Patient Selection from the ASIAN KR Registry | Background: The decision to perform endovascular treatment (EVT) for stroke related to vertebrobasilar occlusion (VBO) remains controversial. Purpose: To identify preprocedural predictors of good outcomes and to develop a model to aid patient selection for VBO. Materials and Methods: For this retrospective study using a Korean multicenter registry, a predictive model for good outcomes (modified Rankin scale score, 0-2) was generated based on a derivation sample of patients with VBO (January 2011February 2016). Preprocedural parameters, including onset-to-puncture time, infarct volume, occlusion type as a surrogate marker of intracranial atherosclerotic stenosis-related occlusion or embolic occlusion (truncal-type occlusion vs branching site occlusion), and collateral status, were analyzed. Continuous variables were dichotomized based on receiver operating characteristic analysis. Multiple logistic regression analysis was performed to generate a predictive model. The model was internally validated with the bootstrap method and was externally validated with a single-center sample (April 2016-December 2018). Results: A predictive model was generated from 71 patients (mean age, 67 years +/- 11 [standard deviation]; 41 [58%] men) and was externally validated in 32 patients (mean age, 72 years 6 13; 19 [59%] men). The composite of initial DW imaging volume of less than 10 mL (odds ratio [OR], 19.3; 95% confidence interval [CI]: 3.0, 126.4; P =.002), onset-to-puncture time of less than 8 hours (OR, 8.7; 95% CI: 1.8, 42.0; P =.007), and branching-site occlusion (OR, 6.1; 95% CI: 1.5, 26.0; P =.01) could be used to predict good outcomes, with a median area under the receiver operating characteristic curve of 0.86 (interquartile range [IQR], 0.77-0.95; bootstrap optimism-corrected C statistic, 0.837) in the derivation sample and 0.78 (IQR, 0.62-0.95) in the validation sample. Results failed to show an association between collateral status and outcome (P =.67). Conclusion: When selecting patients with vertebrobasilar occlusion for endovascular treatment, the combination of onset-topuncture time of less than 8 hours, initial infarct volume of less than 10 mL, and presence of branching-site occlusions is indicative of a good outcome. (C) RSNA, 2020. | Lee, Seong-Joon; Hong, Ji Man; Choi, Jin Wook; Park, Ji Hyun; Park, Bumhee; Kang, Dong-Hun; Kim, Yong-Won; Kim, Yong-Sun; Hong, Jeong-Ho; Yoo, Joonsang; Kim, Chang-Hyun; Sohn, Sung-Il; Hwang, Yang-Ha; Lee, Jin Soo | Ajou Univ, Med Ctr, Dept Neurol, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Ajou Univ, Med Ctr, Dept Radiol, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Ajou Univ, Med Ctr, Dept Biomed Informat, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Ajou Univ, Med Ctr, Sch Med, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Ajou Univ, Med Ctr, Ajou Res Inst Innovat Med, Off Biostat, 164 World Cup Ro, Suwon 16499, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurosurg, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Radiol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurol, Daegu, South Korea; Keimyung Univ, Dongsan Med Ctr, Dept Neurosurg, Daegu, South Korea | Hong, Jeong-Ho/T-8099-2018; Hong, Ji Man/AAE-2686-2022; HWANG, Yang-Ha/F-3068-2013; Hong, Jeong-Ho/AAE-1002-2022; Kim, Chang-Hyun/I-5166-2012 | 7601401252; 55729426200; 55722501000; 57192071799; 57205620923; 8977805800; 56203298200; 57095278300; 55931654800; 55261162200; 56059033400; 36479287000; 7402311308; 55963063300 | jinsoo22@gmail.com; | RADIOLOGY | RADIOLOGY | 0033-8419 | 294 | 3 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 11.105 | 1.1 | 1.65 | 2025-06-25 | 21 | 21 | STENT-RETRIEVER THROMBECTOMY; BASILAR ARTERY; ISCHEMIC-STROKE; COLLATERAL CIRCULATION; THERAPY; SCORE; TIME | Aged; Aged, 80 and over; Area Under Curve; Arterial Occlusive Diseases; Basilar Artery; Endovascular Procedures; Female; Humans; Male; Middle Aged; Models, Statistical; Registries; Treatment Outcome; Vertebral Artery; tissue plasminogen activator; aged; Article; bootstrapping; brain atherosclerosis; brain infarction; brain infarction size; computed tomographic angiography; diagnostic test accuracy study; diffusion weighted imaging; disease registry; endovascular surgery; external validity; female; human; internal validity; Korea; major clinical study; male; occlusive cerebrovascular disease; patient selection; prediction; priority journal; prognosis; Rankin scale; receiver operating characteristic; retrospective study; sensitivity and specificity; time to treatment; treatment outcome; vertebrobasilar insufficiency; very elderly; adverse event; area under the curve; basilar artery; diagnostic imaging; middle aged; peripheral occlusive artery disease; register; statistical model; vertebral artery | English | 2020 | 2020-03 | 10.1148/radiol.2020191227 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
○ | ○ | Review | Removal of particulate matter with metal-organic framework-incorporated materials | Recently, the contamination of air, both indoors and outdoors, has been severe, especially due to particulate matter (PM) in some cities and countries like India, China, and Korea. Therefore, both preventing the evolution of PM and removing PM from air are highly important for sustainability. In this review, progress regarding PM (especially 2.5 mu m or less) removal via filtration is summarized. In particular, air filters modified or composed with metal-organic frameworks (MOFs) or MOF-related materials are discussed, including preparation methods. Moreover, improved performances with the incorporation of MOFs and mechanisms to explain the observations are discussed. Finally, perspectives in the field for effective PM capture/removal with MOF-incorporated filters are suggested after a brief summary of the researches. (C) 2020 Elsevier B.V. All rights reserved. | Yoo, Dong Kyu; Woo, Ho Chul; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | ; Jhung, Sung/AAO-6683-2021 | 57201339246; 57217234591; 6701659467 | sung@knu.ac.kr; | COORDINATION CHEMISTRY REVIEWS | COORDIN CHEM REV | 0010-8545 | 1873-3840 | 422 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2020 | 22.315 | 1.1 | 1.5 | 2025-06-25 | 88 | 86 | Filter; Mechanism; Metal-organic frameworks; Particulate matter; Removal | ZEOLITIC IMIDAZOLATE FRAMEWORK-8; ROOM-TEMPERATURE SYNTHESIS; IN-SITU GROWTH; HIGHLY EFFICIENT; AIR FILTERS; POROUS MATERIALS; FIBROUS MEMBRANES; GAS-ADSORPTION; PM2.5 CAPTURE; FUNCTIONALIZATION | Filter; Mechanism; Metal–organic frameworks; Particulate matter; Removal | English | 2020 | 2020-11-01 | 10.1016/j.ccr.2020.213477 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | Meeting Abstract | Social status and long-term events among acute myocardial infarction patients | Kim, M.; Lee, K. M.; Moon, H. Y.; Jo, Y. S.; Jin, X.; Yuan, S. L.; Kim, R. B.; Hwang, J. Y.; Lee, J. H. | Dong A Univ, Coll Med, Dept Cardiol, Busan, South Korea; Gyeongsang Natl Univ Hosp, Dept Cardiol, Jinju, South Korea; Kyungpook Natl Univ Hosp, Dept Cardiol, Daegu, South Korea | Lee, JongGu/B-7384-2013; Lee, Jeeyun/I-7171-2015 | EUROPEAN HEART JOURNAL | EUR HEART J | 0195-668X | 1522-9645 | 41 | SCIE | CARDIAC & CARDIOVASCULAR SYSTEMS | 2020 | 29.983 | 1.1 | 0 | English | 2020 | 2020-11 | 바로가기 | 바로가기 | ||||||||||||||||
○ | ○ | Article | Task planning strategy and path similarity analysis for an autonomous excavator | Autonomous excavators have attracted significant interest because of their ability to improve productivity and safety. To facilitate their use in construction sites, a proper task planning strategy must be established in advance. This study focuses on the development of a task planning strategy for autonomous excavators. A complete coverage path planning (CCPP) algorithm was developed by considering the characteristics of earthwork and environmental constraints on the autonomous excavator. The algorithm's cost function considers the accessibility of the dump truck and the external condition of the work environment. This enables maximized collaboration with the dump truck to reflect practical solutions, while the majority of the CCPP algorithms consider only the moving distance and internal work environment. In addition, to compare the performance of this algorithm with a conventional task plan generated by a skilled excavator operator, an evaluation scheme that can generate a quantitative result of the path similarity is proposed. Using this evaluation scheme, five cases at distinct construction sites were analyzed to compare the performance of the proposed CCPP algorithm. The results indicate that the CCPP algorithm trends resemble manually determined paths in terms of path similarity. These findings suggest that this algorithm could contribute to the development of autonomous construction equipment-particularly in dynamic and collaborative environments. | Kim, Jeonghwan; Lee, Dong-eun; Seo, Jongwon | KyungPook Natl Univ, Intelligent Construct Automat Ctr, 80 Daehak Ro, Daegu, South Korea; KyungPook Natl Univ, Dept Architectural Engn, 80 Daehak Ro, Daegu, South Korea; Hanyang Univ, Dept Civil & Environm Engn, 222 Wangsimni Ro, Seoul, South Korea | 55720258400; 56605563300; 7401783784 | dolee@knu.ac.kr;jseo@hanyang.ac.kr; | AUTOMATION IN CONSTRUCTION | AUTOMAT CONSTR | 0926-5805 | 1872-7891 | 112 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL | 2020 | 7.7 | 1.1 | 2.08 | 2025-06-25 | 46 | 58 | Autonomous excavator; Task planning strategy; Path planning; Path similarity; Excavation | INTELLIGENT EARTHWORK SYSTEM; TO-POINT MOTION; A-ASTERISK; FRAMEWORK; DESIGN | Autonomous excavator; Excavation; Path planning; Path similarity; Task planning strategy | Cost functions; Employment; Excavation; Excavators; Human engineering; Motion planning; Productivity; Trucks; Autonomous constructions; Autonomous excavators; Collaborative environments; Environmental constraints; Path similarity; Quantitative result; Similarity analysis; Task planning; Construction equipment | English | 2020 | 2020-04 | 10.1016/j.autcon.2020.103108 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Unsteady aerodynamic performance analysis of an airborne wind turbine under load varying conditions at high altitude | The blade air loads of the Airborne Wind Turbine (AWT) may be significantly influenced by the unsteady flow-field at high altitude. Under these susceptible situations, the rotor needs in-depth considerations with respect to transient aspects. The present study focuses on the unsteady aerodynamic performance of stand-alone rotor under the influence of wind shear, yawed, and tilted configurations. The Computational Fluid Dynamics (CFD) transient simulations based on the sliding mesh approach are carried out for analyzing the unsteady behavior of the rotor by lifting the rotor assembly at an airborne altitude from the ground. All simulations are conducted at optimal operating conditions of wind speed and tip speed ratio. In-house Unsteady Blade Element Momentum (UBEM) code using the wind shear, dynamic stall, dynamic wake, and yaw/tilt model are applied to acquire an empirical assessment in terms of rotor torque, thrust, and power coefficient. Finally, the CFD simulated results are compared against the performance curves generated by the UBEM model and acceptable agreement is found within 4.1% deviation at peak operational conditions. The results further reveal that the time-varying aerodynamic loads on the rotor blade gradually achieve steady behavior after three rotation periods. Meanwhile, unique similarities are found in yawed and tilted inflow cases and a 10.7% loss in power coefficient is observed due to rotor yawed inflows. Additionally, in the absence of tower shadows, the strong flow interactions around the rotor blade impose a positive impact on power output. Despite the complexity of unsteady flow phenomena, this present study would be helpful to design a more proficient airborne rotor under the varying load conditions. | Ali, Qazi Shahzad; Kim, Man-Hoe | Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, IEDT, Daegu 41566, South Korea | 57209058973; 55686310000 | manhoe.kim@knu.ac.kr; | ENERGY CONVERSION AND MANAGEMENT | ENERG CONVERS MANAGE | 0196-8904 | 1879-2227 | 210 | SCIE | ENERGY & FUELS;MECHANICS;THERMODYNAMICS | 2020 | 9.709 | 1.1 | 0.68 | 2025-06-25 | 17 | 19 | Unsteady aerodynamics; Airborne wind turbine; Transient simulation; High altitude wind energy; Airborne wind energy; Renewable energy; Computational fluid dynamics | ENERGY; FLOW; CFD; OPTIMIZATION; SYSTEMS; DESIGN | Airborne wind energy; Airborne wind turbine; Computational fluid dynamics; High altitude wind energy; Renewable energy; Transient simulation; Unsteady aerodynamics | Aerodynamic configurations; Aerodynamic stalling; Turbomachine blades; Unsteady flow; Wind; Wind power; Wind turbines; Blade-element momentums; High altitude winds; Operational conditions; Optimal operating conditions; Renewable energies; Transient simulation; Unsteady aerodynamics; Unsteady flow phenomenon; Computational fluid dynamics | English | 2020 | 2020-04-15 | 10.1016/j.enconman.2020.112696 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Intensive weight loss and cognition: The dynamics of persistent organic pollutants in adipose tissue can explain the unexpected results from the Action for Health in Diabetes (Look AHEAD) study | Objective: The aim of this paper is to propose a new hypothesis for the role of lipophilic chemical mixtures stored in adipose tissue in the development of dementia. Specifically, we present how the dynamics of these chemicals can explain the unexpected findings from the Action for Health in Diabetes (Look AHEAD) study, which failed to show long-term benefits of intentional weight loss on cognition, despite substantial improvements in many known risk factors for dementia. Moreover, we discuss how the role of obesity in the risk of dementia can change depending on the dynamics of these chemicals in adipose tissue. New hypothesis: Human adipose tissue is widely contaminated with various neurotoxic chemicals. Typical examples are persistent organic pollutants (POPs), strong lipophilic chemicals with long half-lives. Both unintentional and intentional weight loss increases the release of POPs from adipocytes into the circulation. As POPs in the blood can easily reach the brain, the intentional weight-loss group of the Look AHEAD study may have experienced an unappreciated and long-term disadvantage on their cognition. Additionally, POPs may be involved in the link between obesity and dementia, as dysfunctional hypertrophic adipocytes enhance the release of POPs from adipocytes to the circulation through uncontrolled lipolysis. In contrast, metabolically healthy obese people may have a low risk of dementia because the safe storage of POPs in adipose tissue would decrease the amount of POPs reaching the brain. Major challenges for the hypothesis: In human studies, there are practical difficulties involved with measuring POPs in the blood, including high costs and complex assays. As the serum concentrations of POPs are continuously affected by weight loss and gain, prospective studies may require serial measurements of POPs. In in-vitro and in-vivo experimental studies, how to simulate the exposure dose, duration, and mixture patterns in humans would be critical. Linkage to other major theories: Even though POPs are direct neurotoxins at a high dosage, low-dose POPs are mitochondrial toxins. Therefore, chronic exposure to low-dose POPs is linked to known key interrelated mechanisms in the pathogenesis of dementia, such asmitochondrial dysfunction and neuroinflammation. | Lee, Yu-Mi; Park, Sun-Hee; Lee, Duk-Hee | Kyungpook Natl Univ, Sch Med, Dept Prevent Med, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea | Park, Sun-Hee/LMN-0033-2024 | 57075191600; 7501831741; 57211851121 | lee_dh@knu.ac.kr; | ALZHEIMERS & DEMENTIA | ALZHEIMERS DEMENT | 1552-5260 | 1552-5279 | 16 | 4 | SCIE | CLINICAL NEUROLOGY | 2020 | 21.566 | 1.2 | 0.41 | 2025-06-25 | 9 | 9 | dementia; diabetes; neurotoxic chemicals; obesity; persistent organic pollutants; weight loss | LIFE-STYLE INTERVENTION; ALZHEIMERS-DISEASE; OBESE INDIVIDUALS; ORGANOCHLORINE PESTICIDES; RISK; DEMENTIA; CHEMICALS; POPULATION; MITOCHONDRIA; IMPAIRMENT | dementia; diabetes; neurotoxic chemicals; obesity; persistent organic pollutants; weight loss | Adipose Tissue; Cognition; Environmental Pollutants; Humans; Obesity; Persistent Organic Pollutants; Prospective Studies; Risk Factors; Weight Loss; dioxin; neurotoxin; organochlorine pesticide; polybrominated diphenyl ether; polychlorinated biphenyl; adipocyte; adipose tissue; Article; body weight loss; brain; cognition; dementia; human; lipolysis; lipophilicity; long term exposure; metabolically healthy obese; obesity; persistent organic pollutant; priority journal; adipose tissue; adverse event; body weight loss; pathophysiology; physiology; pollutant; prospective study; risk factor | English | 2020 | 2020-04 | 10.1002/alz.12065 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus | Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1 The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release. | Kwak, Hankyul; Koh, Wuhyun; Kim, Sangwoo; Song, Kiyeong; Shin, Jeong-Im; Lee, Jung Moo; Lee, Elliot H.; Bae, Jin Young; Ha, Go Eun; Oh, Ju-Eun; Park, Yongmin Mason; Kim, Sunpil; Feng, Jiesi; Lee, Seung Eun; Choi, Ji Won; Kim, Ki Hun; Kim, Yoo Sung; Woo, Junsung; Lee, Dongsu; Son, Taehwang; Kwon, Soon Woo; Park, Ki Duk; Yoon, Bo-Eun; Lee, Jaeick; Li, Yulong; Lee, Hyunbeom; Bae, Yong Chul; Lee, C. Justin; Cheong, Eunji | Yonsei Univ, Dept Biotechnol, Coll Life Sci & Biotechnol, Seoul 03722, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci &Technol, Seoul 02792, South Korea; Korea Inst Sci & Technol, Ctr Glia Neuron Interact, Seoul 02792, South Korea; Inst for Basic Sci Korea, Ctr Cognit & Social, Daejeon 34126, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 41566, South Korea; Korea Inst Sci & Technol, Mol Recognit Res Ctr, Seoul 02792, South Korea; Peking Univ, State Key Lab Membrane Biol, Sch Life Sci, Beijing 100871, Peoples R China; Korea Inst Sci & Technol, Res Anim Resource Ctr, Virus Facil, Seoul 02792, South Korea; Korea Inst Sci & Technol, Convergence Res Ctr Diag Treatment & Care Syst De, Seoul 02792, South Korea; Korea Inst Sci & Technol, Doping Control Ctr, Seoul 02792, South Korea; Dankook Univ, Coll Nat Sci, Dept Mol Biol, Cheonan 31116, South Korea; Yonsei Univ, Sch Elect & Elect Engn, Seoul 03722, South Korea; Korea Inst Radiol & Med Sci, Radiat Med Clin Res Div, Seoul, South Korea; Kyung Hee Univ, KHU KIST Dept Converging Sci & Technol, Seoul 02447, South Korea; Peking Univ, Acad Adv Interdisciplinary Studies, Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China; PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China; POSTECH, POSTECH Biotech Ctr, Pohang, South Korea | ; Lee, C./AAC-1663-2019; Koh, Wuhyun/AAR-1320-2021 | 57192555649; 57200079653; 58898889600; 55964125700; 57193427104; 58159576200; 57215669574; 55268279500; 57192423573; 57219975377; 57200080942; 57191270898; 57201660122; 56323972600; 56082603800; 34770932900; 57194641925; 54398095600; 57208294421; 56094965300; 57218381867; 57191756606; 36503095500; 7601483869; 51764131800; 55871790500; 56377838800; 7410148866; 6701592605 | cjl@ibs.re.kr;eunjicheong@yonsei.ac.kr; | NEURON | NEURON | 0896-6273 | 1097-4199 | 108 | 4 | SCIE | NEUROSCIENCES | 2020 | 17.173 | 1.3 | 3.66 | 2025-06-25 | 87 | 88 | EXTRASYNAPTIC GABA(A) RECEPTORS; VENTROBASAL THALAMUS; RETICULAR NUCLEUS; GENE-EXPRESSION; NEURONS; ACTIVATION; CHANNELS; RELEASE; DISCRIMINATION; PHYSIOLOGY | aldehyde dehydrogenase; astrocyte; Best1; diamine oxidase; sensory acuity; tactile discrimination; temporal fidelity; thalamus; tonic GABA; tonic inhibition | Aldehyde Dehydrogenase 1 Family; Amine Oxidase (Copper-Containing); Animals; Astrocytes; Bestrophins; Female; GABA Antagonists; gamma-Aminobutyric Acid; Immunohistochemistry; Inhibitory Postsynaptic Potentials; Macrolides; Male; Mice; Mice, Knockout; Microscopy, Electron; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Primary Cell Culture; Pyridazines; Retinal Dehydrogenase; RNA, Small Interfering; Thalamus; Touch Perception; 4 aminobutyric acid; 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide; 4 aminobutyric acid; 4 aminobutyric acid receptor blocking agent; ALDH1A1 protein, mouse; amine oxidase (copper containing); Best1 protein, mouse; bestrophin; concanamycin A; macrolide; picrotoxin; pyridazine derivative; retinal dehydrogenase; small interfering RNA; 4 aminobutyric acid release; animal cell; animal experiment; animal tissue; Article; astrocyte; brain slice; cell function; controlled study; electron microscopy; firing rate; human; human cell; immunocytochemistry; immunohistochemistry; male; metabolic parameters; molecular imaging; mouse; nerve cell inhibition; nonhuman; open field test; priority journal; protein localization; real time polymerase chain reaction; regulatory mechanism; sensory stimulation; spike wave; synaptic transmission; tactile discrimination; thalamus; whole cell patch clamp; animal; astrocyte; biosynthesis; female; genetics; inhibitory postsynaptic potential; knockout mouse; metabolism; nerve cell; nerve cell inhibition; patch clamp technique; physiology; primary cell culture; thalamus; touch; ultrastructure | English | 2020 | 2020-11-25 | 10.1016/j.neuron.2020.08.013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | Meeting Abstract | Apparent diffusion coefficient as a valuable quantitative parameter for predicting clinical outcomes in patients with newly diagnosed primary CNS lymphoma. | Baek, Dong Won; Lee, Soo Jung; Kang, Byung Woog; Moon, Joon Ho; Kim, Jong Gwang; Sohn, Sang Kyun; Chae, Yee Soo | Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Med Ctr, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Kyungpook Natl Univ Hosp, Dept Hematol Oncol, Daegu, South Korea | Kim, Sung-Bae/JXL-8219-2024 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 38 | 15 | SCIE | ONCOLOGY | 2020 | 44.544 | 1.5 | 0 | English | 2020 | 2020-05-20 | 바로가기 | 바로가기 | |||||||||||||||
○ | Meeting Abstract | Circulating miR-203 secreted from metastatic tissues could exacerbate myopenia in colorectal cancer patients | Okugawa, Yoshinaga; Toiyama, Yuji; Hur, Keun; Ide, Shozo; Shimura, Tadanobu; Fujikawa, Hiroyuki; Yasuda, Hiromi; Yokoe, Takeshi; Hiro, Junichiro; Ohi, Masaki; Kusunoki, Masato | Mie Univ, Tsu, Mie, Japan; Mie Univ, Grad Sch Med, Dept Gastrointestinal & Pediat Surg, Tsu, Mie, Japan; Kyungpook Natl Univ, Daegu, South Korea; Mie Univ, Grad Sch Med, Dept Gastrointestinal, Tsu, Mie, Japan; Mie Univ, Grad Sch Med, Dept Pediat Surg, Tsu, Mie, Japan | Hur, Keun/G-9513-2011 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 38 | 4 | SCIE | ONCOLOGY | 2020 | 44.544 | 1.5 | 0 | English | 2020 | 2020-02-01 | 바로가기 | 바로가기 | |||||||||||||||
○ | ○ | Article | COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm | Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19. Intriguingly, we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients' blood and propose SREBP-2 C-terminal fragment as an indicator for determining severity. We confirmed that SREBP-2-induced cholesterol biosynthesis was suppressed by Sestrin-1 and PCSK9 expression, while the SREBP-2-induced inflammatory responses was upregulated in COVID-19 ICU patients. Using an infectious disease mouse model, inhibitors of SREBP-2 and NF-kappa B suppressed cytokine storms caused by viral infection and prevented pulmonary damages. These results collectively suggest that SREBP-2 can serve as an indicator for severity diagnosis and therapeutic target for preventing cytokine storm and lung damage in severe COVID-19 patients. | Lee, Wonhwa; Ahn, June Hong; Park, Hee Ho; Kim, Hong Nam; Kim, Hyelim; Yoo, Youngbum; Shin, Hyosoo; Hong, Kyung Soo; Jang, Jong Geol; Park, Chun Gwon; Choi, Eun Young; Bae, Jong-Sup; Seo, Young-Kyo | Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Pulmonol & Allergy, Daegu 42415, South Korea; Yeungnam Univ, Reg Ctr Resp Dis, Med Ctr, Daegu 42415, South Korea; Kangwon Natl Univ, Dept Biotechnol & Bioengn, Chunchon 24341, Gangwon Do, South Korea; Korea Inst Sci & Technol KIST, Brain Sci Inst, Ctr BioMicrosyst, Seoul 02792, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Sungkyunkwan Univ SKKU, SKKU Inst Convergence, Dept Biomed Engn, Suwon, South Korea; Sungkyunkwan Univ, Biomed Inst Convergence, SKKU BICS, 2066 Seobu Ro, Suwon 16419, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, BK21 Plus KNU Multi Based Creat Drug Res Team, Coll Pharm,CMRI, Daegu 41566, South Korea | Seo, Young-kyo/AFF-4104-2022; Ahn, June/AAB-3093-2019; Kim, Hong/D-2922-2015; Lee, Wonhwa/GLQ-6506-2022; Kim, Hong Nam/D-2922-2015; Bae, Jong-Sup/AAU-9724-2020 | 50161632800; 56645445800; 25029802100; 35205791200; 57210146478; 57204017274; 57218711481; 56645558700; 56645456400; 40361321700; 57190418295; 16021543200; 24465975600 | letact@yu.ac.kr;baejs@knu.ac.kr;ykseo@kribb.re.kr; | SIGNAL TRANSDUCTION AND TARGETED THERAPY | SIGNAL TRANSDUCT TAR | 2095-9907 | 2059-3635 | 5 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;CELL BIOLOGY | 2020 | 18.187 | 1.5 | 5.25 | 2025-06-25 | 103 | 107 | COVID-19; TRANSCRIPTION; SUPPRESSES; METABOLISM; PATHWAYS; BINDING; PROTEIN; SEPSIS; MTORC1; GENES | Betacoronavirus; Case-Control Studies; Cholesterol; Coronavirus Infections; Cytokine Release Syndrome; Gene Expression Regulation; Heat-Shock Proteins; Host-Pathogen Interactions; Humans; Intensive Care Units; Interleukin-1beta; L-Lactate Dehydrogenase; Leukocytes, Mononuclear; Lung; NF-kappa B; Pandemics; Pneumonia, Viral; Primary Cell Culture; Proprotein Convertase 9; Signal Transduction; Sterol Regulatory Element Binding Protein 2; Survival Analysis; Tumor Necrosis Factor-alpha; ABC transporter A1; alkaline phosphatase; aspartate aminotransferase; C reactive protein; high density lipoprotein cholesterol; immunoglobulin enhancer binding protein; inflammasome; intercellular adhesion molecule 1; interleukin 1beta; interleukin 6; lactate dehydrogenase; messenger RNA; mitogen activated protein kinase 3; monocyte chemotactic protein 1; proprotein convertase 9; sn 50; sterol regulatory element binding protein 2; tumor necrosis factor; vascular cell adhesion molecule 1; cholesterol; heat shock protein; IL1B protein, human; immunoglobulin enhancer binding protein; interleukin 1beta; lactate dehydrogenase; PCSK9 protein, human; proprotein convertase 9; SESN1 protein, human; SREBF2 protein, human; sterol regulatory element binding protein 2; tumor necrosis factor; animal model; animal tissue; Article; cecal ligation and puncture-induced sepsis; cholesterol synthesis; clinical article; controlled study; coronavirus disease 2019; cytokine production; cytokine storm; cytotoxicity; disease severity; enzyme linked immunosorbent assay; gene knockdown; histology; human; human cell; immunoprecipitation; innate immunity; intensive care unit; lipogenesis; lung injury; mortality; mouse; nonhuman; peripheral blood mononuclear cell; protein expression; septic shock; upregulation; urea nitrogen blood level; Western blotting; Betacoronavirus; biosynthesis; case control study; Coronavirus infection; cytokine release syndrome; gene expression regulation; genetics; host pathogen interaction; immunology; lung; metabolism; mononuclear cell; pandemic; pathogenicity; primary cell culture; signal transduction; survival analysis; virology; virus pneumonia | English | 2020 | 2020-09-03 | 10.1038/s41392-020-00292-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | Meeting Abstract | Del-1 and MFG-E8 expression to differentially modulate prognosis of patients with triple-negative breast cancer. | Lee, Soo Jung; Park, Ho Yong; Jung, Jin Hyang; Lee, Jeeyeon; Lee, In Hee; Park, Ji-young; Chae, Yee Soo | Kyungpook Natl Univ, Chilgok Hosp, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Dept Surg, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Daegu, South Korea; Kyungpook Natl Univ, Med Ctr, Sch Med, Dept Oncol Hematol, Daegu, South Korea; Kyungpook Natl Univ, Dept Pathol, Sch Med, Daegu, South Korea; Kyungpook Natl Univ Hosp, Daegu, South Korea | PARK, JUN-YOUNG/P-5981-2015; Park, Jin-Young/HDN-0483-2022 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 38 | 15 | SCIE | ONCOLOGY | 2020 | 44.544 | 1.5 | 0 | English | 2020 | 2020-05-20 | 바로가기 | 바로가기 | |||||||||||||||
○ | Meeting Abstract | Subsequent anticancer procedures following first-line lenvatinib (LEN): A post hoc analysis from the phase III REFLECT study in unresectable hepatocellular carcinoma (uHCC) | Alsina, Angel; Kudo, Masatoshi; Vogel, Arndt; Cheng, Ann-Lii; Tak, Won Young; Ryoo, Baek-Yeol; Evans, T. R. Jeffry; Lopez, Carlos Lopez; Daniele, Bruno; Blanc, Jean-Frederic; Ren, Min; Baldwin, Rae Lynn; Izumi, Namiki; Qin, Shukui; Finn, Richard S. | Tampa Gen Hosp, Tampa, FL 33606 USA; Kindai Univ, Fac Med, Osaka, Japan; Hannover Med Sch, Hannover, Germany; Natl Taiwan Univ Hosp, Taipei, Taiwan; Natl Taiwan Univ, Canc Ctr, Taipei, Taiwan; Kyungpook Natl Univ Hosp, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Seoul, South Korea; Univ Glasgow, Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland; Marques de Valdecilla Univ Hosp, Santander, Spain; Azienda Osped G Rummo, Benevento, Italy; Hosp St Andre, Bourdeaux, France; Eisai Inc, Woodcliff Lake, NJ USA; Musashino Red Cross Hosp, Tokyo, Japan; Nanjing Bayi Hosp, Nanjing, Peoples R China; UCLA Med Ctr, Geffen Sch Med, Santa Monica, CA USA | Cheng, Ann-Lii/ACM-0936-2022; Kudo, Masatoshi/AAA-9744-2019; LOPEZ, CARLOS/ABP-9145-2022; Vogel, Arndt/A-8437-2012; Daniele, Bruno/IAR-5511-2023; Alsina, Angel/E-5347-2010 | JOURNAL OF CLINICAL ONCOLOGY | J CLIN ONCOL | 0732-183X | 1527-7755 | 38 | 4 | SCIE | ONCOLOGY | 2020 | 44.544 | 1.5 | 1 | English | 2020 | 2020-02-01 | 바로가기 | 바로가기 |
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