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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Yolk-shell Fe2O3@mesoporous hollow carbon sphere hybrid sub-micro reactors for effective degradation of organic contaminants | Carbon-metal oxide composites are important class of catalytic materials in persulfate (PS)/peroxymonosulfate (PMS) activation. But, their poor catalytic stability during oxidation limits its practical use. Herein, we demonstrate the yolk-shell architecture strategy for the fabrication of highly stable Fe2O3 mesoporous carbon hollow spheres (Fe2O3@MCHS) catalyst. The prepared material exhibits high PS activation ability for effective degradation of phenolics. The surface properties of hybrid Fe2O3@MCHS system were examined using FE-SEM, TEM, BET and VSM techniques. Physical characterization data confirmed that Fe2O3@MCHS sub-micro reactors possess a magnetic property, high specific surface area (SSA; >1200 m2 g-1), orderly arranged mesopores, and excellent degree of particle dispersion. Owing to the fact, the Fe2O3@MCHS catalyst exhibited highest reactivity for the degradation of 2,4-dichlorophenol and bisphenol-A by PS even with very low catalyst dosage (10 mg L-1). ESR and scavenging experiments exclude the role of reactive radicals and other reactive oxygen species (ROS) (1O2) during pollutant degradation. Open circuit potential (OCP) measurements further reveal that low pollutant degradation efficiencies in the presence of 1O2 scavengers (L-histidine and NaN3) were caused due to strong interaction between scavenging molecules and catalytic surfaces rather than ROS quenching. Electrochemical investigation also supports that degradation occurs through mediating electron transfer from pollutant to Fe2O3@MCHS. This study provides new understanding in PS activation and also in developing stable PS acti-vating hybrid catalytic systems for pollutant degradation. | Kumar, Alam Venugopal Narendra; Shin, Won Sik | Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, Daegu 41566, South Korea | 39262149400; 23019870800 | wshin@knu.ac.kr; | CHEMICAL ENGINEERING JOURNAL | CHEM ENG J | 1385-8947 | 1873-3212 | 465 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL | 2023 | 13.4 | 3.1 | 3.08 | 2025-06-25 | 32 | 32 | Wastewater treatment; Persulfate activation; Phenolic compounds; Mesoporous carbon | ACTIVATION PROCESS; BISPHENOL-A; PERSULFATE; OXIDATION; GROUNDWATER; NANOTUBES; WATER | Fe<sub>2</sub>O<sub>3</sub>; Mesoporous carbon; Persulfate activation; Phenolic compounds; Wastewater treatment | Amino acids; Catalysis; Catalysts; Catalytic oxidation; Chemical activation; Degradation; Free radical reactions; Hematite; Mesoporous materials; Phenols; Mesoporous; Mesoporous carbon; Micro-reactor; Persulfate activations; Persulphate; Phenolic compounds; Pollutant degradation; Reactive oxygen species; Sub micros; ]+ catalyst; Wastewater treatment | English | 2023 | 2023-06-01 | 10.1016/j.cej.2023.142922 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Adsorptive and photocatalytic performance of cobalt-doped ZnTiO3/Ti3C2Tx MXene nanohybrids towards tetracycline: Kinetics and mechanistic insight | Tetracycline (TC) antibiotics are widely used in animal husbandry and can cause environmental risk due to its high ecological toxicity and persistence. In this study, cobalt doped/ZnTiO3 (ZTO)/Ti3C2Tx MXene (ZCxTM, x indicates wt% of Co loading) was synthesized and explored to remove TC by adsorption and photocatalysis under visible light irradiation. The as-prepared ZC5TM was characterized using various analytical techniques, and key operating parameters such as solution pH, background ions, and temperature were systematically investigated. Interestingly, ZC5TM (14.9 mg/g) showed excellent adsorption capacity for TC, which was higher than activated carbon (7.7 mg/g), ZTO (4.9 mg/g), ZC3T (5.2 mg/g), ZC5T (5.3 mg/g), MXene (12.1 mg/g), ZTOM (12.5 mg/g), and ZC3TM (12.9 mg/g). The pseudo-second-order kinetics and Langmuir isotherm models well explained the effect of contact time and initial concentrations on the adsorption of TC. The adsorption process was primarily through the electrostatic attraction, surface complexation, and hydrogen bonding. In addition, MXene and Co doped on ZTO served as co-catalyst and reduced recombination rate of photo-generated e--h+ pairs by the intimate interface of its heterojunction. Thus, ZC5TM was highly effective for the photocatalytic degradation of residual TC after adsorption by showing 18% TC degradation rate, compared to 8% and 9% degradation rate for ZTO and MXene, respectively. There results finally support the feasible use of ZC5TM as efficient adsorbent and photocatalyst in removal of TC in wastewater. | Park, Soyoung; Kim, Sewoon; Yea, Yeonji; Saravanakumar, Karunamoorthy; Lee, Eunji; Yoon, Yeomin; Park, Chang Min | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak ro, Daegu 41566, South Korea; Univ Iowa, Dept Civil & Environm Engn, 4105 Seamans Ctr, Iowa, IA 52242 USA; Univ South Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA; Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae gil, Seoul 03760, South Korea | Park, Chang Min/CAA-8506-2022; Yoon, Yeomin/KDP-2253-2024; Karunamoorthy, Saravanakumar/Q-2005-2016 | 58180532500; 57201422323; 57217304205; 57223020778; 57143076400; 7402126688; 57209588953 | soyng7818@naver.com;sewoon-kim@uiowa.edu;dpduswl@naver.com;sravanan205@gmail.com;venturoso1004@naver.com;yoony@cec.sc.edu;cmpark@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 443 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 5.12 | 2025-06-25 | 52 | 54 | ZnTiO3; MXene; Adsorption; Photodegradation; Tetracycline | WASTE-WATER; NANOCOMPOSITE; DEGRADATION; REMOVAL; DIOXIDE; FE | Adsorption; MXene; Photodegradation; Tetracycline; ZnTiO<sub>3</sub> | Activated carbon; Adsorption; Charge transfer; Cobalt; Degradation; Heterojunctions; Hydrogen bonds; Isotherms; Zinc compounds; activated carbon; adsorbent; cobalt; graphene oxide; perovskite; tetracycline; titanium carbide; unclassified drug; zinc titanate; Animal husbandry; Degradation rate; Environmental risks; Mechanistics; Mxene; Nanohybrids; Photo degradation; Photocatalytic performance; Tetracycline; Tetracycline antibiotics; adsorption; catalysis; environmental risk; kinetics; photodegradation; adsorption kinetics; Article; catalyst; contact time; hydrogen bond; pH; photocatalysis; photodegradation; physical chemistry; static electricity; surface property; temperature; ultrasound; waste water management; Titanium compounds | English | 2023 | 2023-02-05 | 10.1016/j.jhazmat.2022.130165 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adsorptive removal of aromatic diamines from water using metal-organic frameworks functionalized with a nitro group | Adsorptive removal of aromatic diamines such as methylenedianiline (MDA) and p-phenylenediamine (PPD) was firstly investigated with nitro-functionalized metal-organic frameworks (MOFs, MIL-101(Cr)-NO2). The MIL-101 (Cr)-NO2 showed much better performances in the removal of MDA and PPD, in both adsorption capacity and kinetics, than any other adsorbents. For example, MIL-101(Cr)-NO2 had a much higher maximum adsorption capacity for MDA (1111 mg.g(-1)) than activated carbon (208 mg.g(-1)) or a reported adsorbent (391 mg.g(-1)). Based on experimental results, hydrogen bonding (especially, via the formation of a 6-membered ring (6-MR) between -NO2 of the adsorbent and -NH2 of the adsorbates) could be suggested as the main mechanism to interpret the noticeable adsorption of the diamines. Importantly, this is the first example to confirm that MOFs with nitro group can be a competitive adsorbent to remove organics composed of amino group, especially via making 6-MR through hydrogen bonding. Higher adsorption of MDA than that of PPD over MIL-101(Cr)-NO2 might be explained with pi-pi interaction between aromatic rings (pi-lean aromatics of MOF and pi-rich aromatics of the adsorbates). Moreover, MIL-101(Cr)-NO2 could be recycled after simple washing, suggesting the potential use of the MOF in adsorptive purification of contaminated water with organics with amino groups. | Lee, Gyudong; Park, Geondo; Kim, Sunghwan; Jhung, Sung Hwa | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea | ; Jhung, Sung/AAO-6683-2021; Kim, Sunghwan/HKN-9812-2023 | 57200987600; 57932478900; 57203772967; 6701659467 | sunghwank@knu.ac.kr;sung@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 443 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 3.03 | 2025-06-25 | 31 | 32 | Adsorption; Aromatic diamines; H-bonding; 6-membered ring; MIL-101-NO2 | P-ARSANILIC ACID; EMERGING CONTAMINANTS; MOFS; MIL-101; TOXICITY; CATALYST; SORPTION; OXIDE | 6-membered ring; Adsorption; Aromatic diamines; H-bonding; MIL-101-NO<sub>2</sub> | Activated carbon; Aromatic compounds; Aromatization; Crystalline materials; Hydrogen; Hydrogen bonds; Metal-Organic Frameworks; Nitrogen oxides; Organic polymers; Water pollution; 4,4' methylenedianiline; activated carbon; adsorbent; chromium; diamine; glyceryl trinitrate; metal organic framework; nitrobenzene; nitrogen; nitrogen dioxide; phenylenediamine; water; 6-membered rings; Adsorptive removal; Aromatic diamine; Functionalized; H-bonding; Metalorganic frameworks (MOFs); Methylene dianiline; MIL-101-NO2; P-phenylene diamines; P-phenylenediamine; activated carbon; adsorption; chemical bonding; hydrogen; pollutant removal; purification; adsorption kinetics; Article; chemical interaction; chemical reaction; controlled study; hydrogen bond; kinetic parameters; purification; static electricity; surface area; thermostability; waste component removal; water contamination; Adsorption | English | 2023 | 2023-02-05 | 10.1016/j.jhazmat.2022.130133 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | ECM-targeting bacteria enhance chemotherapeutic drug efficacy by lowering IFP in tumor mouse models | Bacterial cancer therapies aim to manipulate bacteria to effectively deploy therapeutic payloads to tumors. Attenuated bacteria alone often cannot eradicate solid tumors. Attenuated Salmonella can be engineered to deliver cytotoxic drugs to either trigger an immune response or increase antitumor efficacy when combined with chemotherapeutic drugs. However, the extracellular matrix (ECM) surrounding cancer cells forms a barrier that often limits the ability of chemotherapeutic and cytotoxic drugs to penetrate and eliminate tumors. To overcome this limitation, we developed a strategy to combine chemotherapy with an attenuated Salmonella typhimurium strain engineered to secrete HysA protein (from Staphylococcus aureus; Hyaluronidase, HAase) in tumors. The engineered Salmonella effectively degraded hyaluronan (HA), which is a major ECM constituent in tumors, and suppressed tumor growth in mouse models of pancreatic adenocarcinoma (ASPC-1) and breast cancer (4T1). Furthermore, it prolonged survival when combined with chemotherapeutic drugs (doxorubicin or gemcitabine). Upon bacterial colonization, the HAase-mediated ECM degradation decreased interstitial fluid pressure (IFP) in the tumor microenvironment. Additionally, HA degradation using HAase-expressing bacteria in vivo led to decreased binding to the receptor, CD44, expressed in tumors. This may modulate proliferation-and apoptosis-related signal pathways. Therefore, ECM-targeting bacteria can be used as a synergistic anticancer therapeutic agent to maximize chemotherapeutic drug delivery into highly invasive tumors. | Kim, Ji-Sun; Park, Jam-Eon; Choi, Seung-Hyeon; Kang, Se Won; Lee, Ju Huck; Lee, Jung-Sook; Shin, Minsang; Park, Seung-Hwan | Korea Res Inst Biosci & Biotechnol KRIBB, Biol Resource Ctr, Jeongeup 56212, South Korea; Kyungpook Natl Univ, Sch Med, Dept Microbiol, 680 Gukchaebosang Ro, Daegu 41944, South Korea | Lee, Jong Min/HJY-8328-2023; Kang, sewon/KHX-8924-2024 | 57201949224; 57205247060; 57205250433; 56834794400; 57194348432; 56052405400; 7401536650; 35074781200 | biopark@kribb.re.kr; | JOURNAL OF CONTROLLED RELEASE | J CONTROL RELEASE | 0168-3659 | 1873-4995 | 355 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2023 | 10.5 | 3.2 | 4.46 | 2025-06-25 | 32 | 30 | Hyaluronidase; Extracellular matrix; Chemotherapeutic drug; Drug delivery; Bacterial cancer therapy | ENGINEERED SALMONELLA-TYPHIMURIUM; HYALURONIC-ACID; CANCER-THERAPY; GROWTH; CHOLERAESUIS; METASTASIS; EXPRESSION; INDUCTION; DELIVERY; STROMA | Bacterial cancer therapy; Chemotherapeutic drug; Drug delivery; Extracellular matrix; Hyaluronidase | Adenocarcinoma; Animals; Antineoplastic Agents; Extracellular Fluid; Extracellular Matrix; Mice; Pancreatic Neoplasms; Tumor Microenvironment; Biodegradation; Cancer cells; Cell death; Chemotherapy; Controlled drug delivery; Diseases; Drug products; Salmonella; Targeted drug delivery; arabinose; binding protein; doxorubicin; gemcitabine; genomic DNA; Hermes antigen; hyaluronic acid; hyaluronidase; isoflurane; ketamine; paclitaxel; recombinant protein; xylazine; antineoplastic agent; Bacterial cancer therapy; Cancer therapy; Chemotherapeutic drugs; Cytotoxic drugs; Drug efficacy; Extracellular matrices; Hyaluronidase; Interstitial fluid pressures; Mice models; Solid tumors; 4T1 cell line; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; AsPC-1 cell line; bacterial bioluminescence; bacterial colonization; bacterial count; bacterial growth; bacterial strain; bacteriotherapy; breast cancer; cancer inhibition; controlled study; drug efficacy; extracellular matrix; female; histopathology; human; human cell; in vitro study; in vivo study; male; mouse; nonhuman; pancreas adenocarcinoma; plasmid; Salmonella enterica serovar Typhimurium; Staphylococcus aureus; synergistic effect; tissue pressure; tumor microenvironment; tumor xenograft; adenocarcinoma; animal; extracellular fluid; metabolism; pancreas tumor; Tumors | English | 2023 | 2023-03 | 10.1016/j.jconrel.2023.02.001 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Enhanced catalytic oxidation of naproxen via activation of peroxymonosulfate by Fe-based metal-organic framework aerogels functionalized with Ag nanoparticles | In this study, Ag3PO4 and Fe-based metal-organic frameworks (MOFs)-functionalized three-dimensional (3D) porous gelatin aerogels (Ag/Fe@GMA) were fabricated and used as adsorbents and catalysts for the activation of peroxymonosulfate (PMS) for naproxen (NPX) removal from water. The morphology, crystallinity, surface functional groups, and surface chemical element compositions of the fabricated Ag/Fe@GMA was evaluated using various analytical techniques. Our results showed that as an adsorbent, Ag/Fe@GMA showed a 18.0 % higher NPX adsorption capacity compared with the pristine aerogels. This can be attributed to the well -embedded Ag3PO4 and MOFs, indicating a stronger interaction between functionalized aerogels and NPX. After adsorption, 99.9 % of total NPX removal was achieved within 15 min by activating PMS and effectively generating & BULL;OH and & BULL;SO4 in water. The PMS/Ag/Fe@GMA aerogel system also showed high removal performance for rhodamine B (99.5 %) and tetracycline (93.7 %). Moreover, the Ag/Fe@GMA aerogels showed excellent reusability to achieve 95.7 % NPX removal efficiency after six times of recycling. This study revealed that the Ag/Fe@GMA aerogels had good potential for PMS activation and NPX removal. In particular, as an alternative to powdery materials, 3D shape of Ag/Fe@GMA with excellent reusability facilitates its application in the treatment of water contaminated with organic contaminants. | Cha, Byungjun; Yea, Yeonji; Yun, Keunyoung; Kim, Taeyeon; Kim, Hyeonjeong; Yoon, Yeomin; Kim, Sewoon; Park, Chang Min | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Univ South Carolina, Dept Civil & Environm Engn, 300 Main St, Columbia, SC 29208 USA; Ewha Womans Univ, Dept Environm Sci & Engn, 52 Ewhayeodae Gil, Seoul 03760, South Korea; Univ Iowa, Dept Civil & Environm Engn, Iowa City, IA 52242 USA | ; Kim, Tae Hyun/GNP-3195-2022; Park, Chang Min/CAA-8506-2022; Yoon, Yeomin/KDP-2253-2024 | 57337280900; 57217304205; 57884548300; 58031481400; 58421791300; 7402126688; 57201422323; 57209588953 | sewoon-kim@uiowa.edu;cmpark@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 458 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 1.23 | 2025-06-25 | 13 | 13 | Gelatin aerogel; Ag3PO4; Metal-organic frameworks; Naproxen; Peroxymonosulfate | LIGHT PHOTOCATALYTIC ACTIVITY; EFFICIENT DEGRADATION; HYDROPHOBIC INTERACTIONS; WATER; GELATIN; PHARMACEUTICALS; PERFORMANCE; MECHANISMS; ADSORPTION; SEPARATION | Ag<sub>3</sub>PO<sub>4</sub>; Gelatin aerogel; Metal–organic frameworks; Naproxen; Peroxymonosulfate | Aerogels; Catalytic oxidation; Chemical activation; Crystallinity; Iron compounds; Metal nanoparticles; Morphology; Reusability; Silver nanoparticles; Water treatment; adsorbent; aerogel; iron; metal organic framework; naproxen; peroxy radical; peroxymonosulfate; rhodamine B; silicon dioxide; silver nanoparticle; tetracycline; unclassified drug; water; Cristallinity; Fe-based; Functional surfaces; Functionalized; Gelatin aerogel; Metalorganic frameworks (MOFs); Naproxens; Peroxymonosulfate; Surface functional groups; ]+ catalyst; adsorption; catalysis; catalyst; chemical element; drug; organic pollutant; performance assessment; pollutant removal; salt; silver; adsorption; Article; decomposition; degradation; energy dispersive X ray spectroscopy; Fourier transform infrared spectroscopy; oxidation; recycling; scanning electron microscopy; static electricity; surface area; surface property; tandem mass spectrometry; thermogravimetry; thermostability; transmission electron microscopy; ultra performance liquid chromatography; waste component removal; zeta potential; Silver compounds | English | 2023 | 2023-09-15 | 10.1016/j.jhazmat.2023.131847 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Integrative multi-omics reveals analogous developmental neurotoxicity mechanisms between perfluorobutanesulfonic acid and perfluorooctanesulfonic acid in zebrafish | The molecular mechanism of perfluorobutanesulfonic acid (PFBS), an alternative to legacy perfluorooctanesulfonic acid (PFOS), is not fully understood yet. Therefore, we conducted a developmental toxicity evaluation on zebrafish embryos exposed to PFBS and PFOS and assessed neurobehavioral changes at concentrations below each point of departure (POD) determined by embryonic mortality. Using transcriptomics, proteomics, and metabolomics, biomolecular perturbations in response to PFBS were profiled and then integrated for comparison with those for PFOS. Although PFBS (7525.47 & mu;M POD) was approximately 700 times less toxic than PFOS (11.42 & mu;M POD), altered neurobehavior patterns and affected kinds of endogenous neurochemicals were similar between PFBS and PFOS at the corresponding POD-based concentrations. Multi-omics analysis revealed that the PFBS neurotoxicity mechanism was associated with oxidative stress, lipid metabolism, and glycolysis/glucogenesis. The commonalities in developmental neurotoxicity-related mechanisms between PFBS and PFOS interconnected by knowledge-based integration of multi-omics included the calcium signaling pathway, lipid homeostasis, and primary bile acid biosynthesis. Despite being less toxic than PFOS, PFBS exhibited similar dysregulated molecular mechanisms, suggesting that chain length differences do not affect the intrinsic toxicity mechanism. Overall, carefully managing potential toxicity of PFBS can secure its status as an alternative to PFOS. | Min, Eun Ki; Lee, Hyojin; Sung, Eun Ji; Seo, Seong Woo; Song, Myungha; Wang, Seungjun; Kim, Seong Soon; Bae, Myung Ae; Kim, Tae-Young; Lee, Sangkyu; Kim, Ki-Tae | Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea; Univ Ottawa, Dept Biol, Ottawa, ON K1N 6N5, Canada; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Gwangju Inst Sci & Technol, Sch Earth Sci & Environm Engn, Gwangju 61005, South Korea; Natl Inst Environm Res, Environm Hlth Res Dept, Incheon 22689, South Korea; Korea Res Inst Chem Technol, Bio & Drug Discovery Div, Daejeon 34114, South Korea; Sungkyunkwan Univ, Sch Pharm, Suwon 16419, South Korea; Seoul Natl Univ Sci & Technol, Seoul, South Korea | ; KIM, KI-TAE/AAX-3175-2020; Kim, Seong Soon/IZE-2538-2023 | 57221692953; 57200522840; 56988948200; 57201981362; 58341070100; 56697885300; 57194944619; 7005711682; 57049826900; 57209046767; 57202074566 | kimtaeyoung@gist.ac.kr;sangkyu@skku.edu;ktkim@seoultech.ac.kr;kimtaeyoung@gist.ac.k; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 457 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 2.94 | 2025-06-25 | 33 | 33 | Perfluoroalkyl substances; Alternative; Legacy; Molecular mechanism; Point of departure | EXPRESSION; BEHAVIOR | Alternative; Legacy; Molecular mechanism; Perfluoroalkyl substances; Point of departure | Alkanesulfonic Acids; Animals; Fluorocarbons; Multiomics; Zebrafish; Biochemistry; Knowledge based systems; Molecular biology; bile acid; calcium; lipid; perfluorooctanesulfonic acid; sulfonic acid derivative; alkanesulfonic acid; fluorocarbon; perfluorobutanesulfonic acid; perfluorooctanesulfonic acid; 'omics'; Alternative; Developmental neurotoxicity; Developmental toxicity; Legacy; Molecular mechanism; Perfluoroalkyl substances; Point of departures; Zebrafish; Zebrafish embryos; chemical pollutant; cyprinid; developmental biology; genomics; molecular analysis; toxicity; adult; animal experiment; animal model; animal tissue; Article; bile acid synthesis; calcium signaling; concentration (parameter); controlled study; developmental toxicity; embryo; embryo mortality; lipid homeostasis; lipid metabolism; metabolomics; multiomics; neurotoxicity; nonhuman; oxidative stress; proteomics; transcriptomics; zebra fish; animal; multiomics; Toxicity | English | 2023 | 2023-09-05 | 10.1016/j.jhazmat.2023.131714 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Loop-seal flow characteristics of a circulating fluidized bed for 3 MWth scale chemical looping combustion system | This study aimed to provide a design and operational approach for a loop-seal, which is the heart of a circulating fluidized bed (CFB). Thousands of CFB systems use this non-mechanical valve to optimize performance by controlling the solids circulation rate while preventing gas mixing between reactors. Nevertheless, its design and operating guidance remains unclear because of its intricate flow characteristics, causing confusion in design and operation of the entire CFB. This study experimentally investigated the three most important elements while designing and operating loop-seal: conditions for initiating solids flow, the maximum obtainable solids flow rate, and quantitative control of solids flow rate. Experiments were conducted in a CFB, which simulated 3 MWth chemical looping combustion (CLC) system that is currently being developed. The onset of solids flow occurs when the gas drag force in horizontal passage overcomes the resistance force generated by the bed of particles. The maximum solids circulation rate was determined by solids height in the supply chamber and pressure around CFB loop. A correlation for quantitative control of solids flow in loop-seal was proposed by the relationship between the gas drag force and particle velocity. Finally, operational conditions for the loop-seal in 3 MWth CLC were proposed. | Kim, Daewook; Won, Yooseob; Hwang, Byung Wook; Kim, Jae Young; Kim, Hana; Choi, Yujin; Lee, Yu-Ri; Lee, Seung-Yong; Jo, Sung-Ho; Park, Young Cheol; Baek, Jeom-In; Nam, Hyungseok; Lee, Doyeon; Ryu, Ho -Jung; Choi, Jeong-Hoo | Korea Inst Energy Res, 152 Gajeong Ro, Daejeon 34129, South Korea; Korea Elect Power Corp Res Inst, 105 Munji Ro, Daejeon 34056, South Korea; Kyungpook Natl Univ, 80 Daehak Ro, Daegu 41566, South Korea; Hanbat Natl Univ, 125 Dongseo Daero, Daejeon 34158, South Korea; Konkuk Univ, 120 Neungdong Ro, Seoul 05029, South Korea | Lee, Yu-Ri/AAC-2180-2021; Ryu, Ho-Jung/AAV-3451-2020 | 55569361600; 57212454920; 44461423600; 57212451216; 57196215454; 57734617200; 55234857100; 57203597352; 55246098400; 55494383600; 7103228396; 57190418228; 55881252900; 7202277238; 7501392397 | hjryu@kier.re.kr; | ENERGY | ENERGY | 0360-5442 | 1873-6785 | 274 | SCIE | ENERGY & FUELS;THERMODYNAMICS | 2023 | 9 | 3.2 | 1.01 | 2025-06-25 | 9 | 10 | Circulating fluidized bed; Solids circulation rate; Chemical looping combustion; 3 MWth; Loop-seal | PRESSURE-DROP; CHOKING; SOLIDS; MODEL; GAS; OPERATION; VELOCITY | 3 MWth; Chemical looping combustion; Circulating fluidized bed; Loop-seal; Solids circulation rate | Coal combustion; Drag; Fluidization; Fluidized bed combustion; Fluidized bed process; Valves (mechanical); Velocity control; 3 mwth; Chemical looping combustion; Circulating fluidized bed; Combustion systems; Drag forces; Flow characteristic; Fluidized bed system; Loop seal; Solid circulation rates; Solids flow; combustion; drag; mixing; pressure effect; Fluidized beds | English | 2023 | 2023-07-01 | 10.1016/j.energy.2023.127271 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Phosphine gas in the dark induces severe phytotoxicity in Arabidopsis thaliana by increasing a hypoxia stress response and disrupting the energy metabolism: Transcriptomic approaches | Phosphine (PH3) is an ideal fumigant alternative on methyl bromide (MB) as MB has been classified as an ozone -depleting substance. However, several challenges limit its efficient use in crop production, including the emergence of PH3-resistant insect pests and the incidence of phytotoxic effects on nursery plants. Therefore, this study aims to elucidate the mechanism underlying PH3 phytotoxicity in plants using transcriptomic techniques. Fumigation with 2 g/m3 PH3 induced phytotoxic effects in A. thaliana, as evidenced by a decrease in growth and vegetation indices compared to the control group. Transcriptomic analysis revealed that PH3 fumigation phytotoxicity responses in A. thaliana involve genes related to hypoxia stress and energy metabolism. Addi-tionally, pretreatment with ethylene induced pre-adaptation to hypoxia under light conditions during fumigation effectively suppressed the phytotoxic effects of PH3 in A. thaliana by increasing the expression of hypoxia-adaptive genes. Moreover, the phytotoxicity of PH3 was also confirmed in pumpkin (Cucurbita moschata Duch.), and was dependent on light. Overall, our findings showed that fumigation under light conditions and ethylene pretreatment could be used to minimize PH3-induced phytotoxic effects in plants. | Kim, Kyeongnam; Kim, Chaeeun; Yoo, Jinsung; Kim, Jun-Ran; Kim, Yoon-Ha; Lee, Sung-Eun | Kyungpook Natl Univ, Dept Appl Biosci, Daegu 41566, South Korea; Anim & Plant Quarantine Agcy, Plant Quarantine Technol Ctr, Gimcheon 39660, South Korea | Kim, Kyeongnam/KSM-2719-2024 | 57191364349; 57200245142; 57935332000; 7601367625; 57224866763; 55890041600 | selpest@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 443 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 0.19 | 2025-06-25 | 2 | 2 | Fumigation; Mechanism of toxicity; Ethylene; Photoperiod; Electron transport chain | TOXICITY; LIFE | Electron transport chain; Ethylene; Fumigation; Mechanism of toxicity; Photoperiod | Cultivation; Electron transport properties; Fumigation; Metabolism; Phosphorus compounds; Physiology; Plants (botany); ethylene; phosphine; pyruvate decarboxylase; sulfur; Electron transport chain; Energy metabolism; Hypoxia stress; Mechanism of toxicity; Methyl bromide; Photoperiod; Phytotoxic effects; Pre-treatments; Thaliana; Transcriptomics; ethylene; methyl bromide; Arabidopsis thaliana; Article; carbon fixation; controlled study; Cucurbita moschata; energy metabolism; fumigation; gene expression; hypoxia; light; metabolism; nitrogen metabolism; nonhuman; photoperiodicity; photosynthesis; phytotoxicity; plant growth; plant stress; squash; transcriptomics; vegetation; Ethylene | English | 2023 | 2023-02-05 | 10.1016/j.jhazmat.2022.130141 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Protein-based nanocages for vaccine development | Protein nanocages have attracted considerable attention in various fields of nanomedicine due to their intrinsic properties, including biocompatibility, biodegradability, high structural stability, and ease of modification of their surfaces and inner cavities. In vaccine development, these protein nanocages are suited for efficient tar-geting to and retention in the lymph nodes and can enhance immunogenicity through various mechanisms, including excellent uptake by antigen-presenting cells and crosslinking with multiple B cell receptors. This re-view highlights the superiority of protein nanocages as antigen delivery carriers based on their physiological and immunological properties such as biodistribution, immunogenicity, stability, and multifunctionality. With a focus on design, we discuss the utilization and efficacy of protein nanocages such as virus-like particles, caged proteins, and artificial caged proteins against cancer and infectious diseases such as coronavirus disease 2019 (COVID-19). In addition, we summarize available knowledge on the protein nanocages that are currently used in clinical trials and provide a general outlook on conventional distribution techniques and hurdles faced, partic-ularly for therapeutic cancer vaccines. | Kim, Seong A.; Lee, Yeram; Ko, Yeju; Kim, Seohyun; Kim, Gi Beom; Lee, Na Kyeong; Ahn, Wonkyung; Kim, Nayeon; Nam, Gi-Hoon; Lee, Eun Jung; Kim, In-San | Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Chem & Biol Integrat Res Ctr, Seoul, South Korea; Kyungpook Natl Univ, Dept Chem Engn, Daegu, South Korea; SHIFTBIO INC, Dept Res & Dev, Seoul, South Korea; Korea Univ, Coll Med, Dept Biochem & Mol Biol, Seoul, South Korea | ; Lee, Seung Eun/ABG-1607-2021; Nam, Gi-Hoon/I-6664-2018 | 57211273596; 57370627900; 58022337100; 57212447863; 57197865834; 57188655309; 57222252868; 59884547500; 57192919427; 57239965200; 34770432800 | eunjunglee@knu.ac.kr;iskim14@kist.re.kr; | JOURNAL OF CONTROLLED RELEASE | J CONTROL RELEASE | 0168-3659 | 1873-4995 | 353 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2023 | 10.5 | 3.2 | 3.19 | 2025-06-25 | 22 | 21 | Protein nanocage; Virus -like particle; Vaccine; Cancer vaccine; SARS-CoV-2 | VIRUS-LIKE PARTICLES; HEAT-SHOCK-PROTEIN; NEUTRALIZING ANTIBODY-RESPONSES; ORIGINAL ANTIGENIC SIN; IN-SITU VACCINATION; MOSAIC-VIRUS; NANOPARTICLE VACCINES; DRUG-DELIVERY; PROTECTIVE IMMUNITY; FERRITIN NANOCAGE | Cancer vaccine; Protein nanocage; SARS-CoV-2; Vaccine; Virus-like particle | Antibodies, Viral; COVID-19; COVID-19 Vaccines; Humans; Tissue Distribution; Vaccine Development; Antigens; Biocompatibility; Biodegradability; Cell membranes; Diseases; Medical nanotechnology; Proteins; Stability; Vaccines; cancer vaccine; heat shock protein; nanocage; SARS-CoV-2 vaccine; virus antibody; Cancer vaccine; Immunogenicity; Inner cavities; Intrinsic property; Nanocages; Protein nanocage; Structural stabilities; Surface cavity; Vaccine development; Virus-like particles; antibody affinity; antibody response; antigen presentation; antigen presenting cell; area under the curve; Article; biodegradability; bone marrow derived macrophage; cancer immunization; cancer immunotherapy; chemical reaction; coronavirus disease 2019; crystal structure; cytopathogenic effect; Enterobacteria phage MS2; germinal center; human; humoral immunity; immune response; immunogenicity; immunoreactivity; limit of detection; nonhuman; phagocytosis; therapy effect; thermostability; tumor immunity; tumor microenvironment; vaccine development; vaccine production; virus like agent; virus morphology; prevention and control; tissue distribution; Coronavirus | English | 2023 | 2023-01 | 10.1016/j.jconrel.2022.12.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Rice pollen-specific OsRALF17 and OsRALF19 are essential for pollen tube growth | Pollen tube growth is essential for successful double fertilization, which is critical for grain yield in crop plants. Rapid alkalinization factors (RALFs) function as ligands for signal transduction during fertilization. However, functional studies on RALF in monocot plants are lacking. Herein, we functionally characterized two pollen-specific RALFs in rice (Oryza sativa) using multiple clustered regularly interspaced palindromic repeats (CRISPR)/CRISPR-associated protein 9-induced loss-of-function mutants, peptide treatment, expression analyses, and tag reporter lines. Among the 41 RALF members in rice, OsRALF17 was specifically expressed at the highest level in pollen and pollen tubes. Exogenously applied OsRALF17 or OsRALF19 peptide inhibited pollen tube germination and elongation at high concentrations but enhanced tube elongation at low concentrations, indicating growth regulation. Double mutants of OsRALF17 and OsRALF19 (ralf17/19) exhibited almost full male sterility with defects in pollen hydration, germination, and tube elongation, which was partially recovered by exogenous treatment with OsRALF17 peptide. This study revealed that two partially functionally redundant OsRALF17 and OsRALF19 bind to Oryza sativa male-gene transfer defective 2 (OsMTD2) and transmit reactive oxygen species signals for pollen tube germination and integrity maintenance in rice. Transcriptomic analysis confirmed their common downstream genes, in osmtd2 and ralf17/19. This study provides new insights into the role of RALF, expanding our knowledge of the biological role of RALF in regulating rice fertilization. | Kim, Eui-Jung; Kim, Ji-Hyun; Hong, Woo-Jong; Kim, Eun Young; Kim, Myung-Hee; Lee, Su Kyoung; Min, Cheol Woo; Kim, Sun Tae; Park, Soon Ki; Jung, Ki-Hong; Kim, Yu-Jin | Kyung Hee Univ, Grad Sch Green Biosci, Yongin 17104, South Korea; Pusan Natl Univ, Life & Ind Convergence Res Inst, Dept Life Sci & Environm Biochem, Miryang 50463, South Korea; Kyung Hee Univ, Dept Smart Farm Sci, Yongin 17104, South Korea; Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Natl Inst Agr Sci, Rural Dev Adm, Dept Agr Bioresources, Genom Div, Jeonju 54874, South Korea; Pusan Natl Univ, Dept Plant Biosci, Miryang 50463, South Korea; Seoul Natl Univ, Res Ctr Plant Plast, Seoul 08826, South Korea | Kim, YuJin/NQE-8241-2025; Jung, Ki/L-5570-2019; Hong, Woo-Jong/HPF-0756-2023 | 57214231436; 59642475200; 57194418669; 58353459000; 57221718078; 57223132353; 57189515849; 57225142626; 8055974900; 56022522000; 57074286200 | khjung2010@khu.ac.kr;yjkim2020@pusan.ac.kr; | JOURNAL OF INTEGRATIVE PLANT BIOLOGY | J INTEGR PLANT BIOL | 1672-9072 | 1744-7909 | 65 | 9 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;PLANT SCIENCES | 2023 | 9.3 | 3.2 | 1.92 | 2025-06-25 | 14 | 14 | CRISPR-Cas9; CrRLK1L; monocot; Oryza sativa; pollen tube growth; rapid alkalinization factor (RALF) | RALF; PEPTIDES; KINASE; POLYPEPTIDE; GERMINATION; ENDOCYTOSIS; GENERATION; INTEGRITY; PROTEINS; TOBACCO | CRISPR-Cas9; CrRLK1L; monocot; Oryza sativa; pollen tube growth; rapid alkalinization factor (RALF) | Oryza; Peptides; Pollen; Pollen Tube; Signal Transduction; peptide; alkalinization; biotechnology; fertilizer application; gene expression; growth; monocotyledon; pollen; rice; genetics; Oryza; pollen; pollen tube; signal transduction | English | 2023 | 2023-09 | 10.1111/jipb.13508 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Study on energy consumption characteristics of passenger electric vehicle according to the regenerative braking stages during real-world driving conditions | Electric vehicles are affected by various factors such as the ambient temperature, traffic conditions, driver behavior, vehicle weight, and route characteristics. This study evaluated the energy efficiency of an electric SUV with regenerative braking system under real-world driving conditions. Data were collected using a controller area network while driving on the same route at each regenerative braking stage. Chassis dynamometer tests were performed to verify battery consumption during acceleration and regenerative braking. From the real-world driving test, it was determined that as the regenerative braking stage increased, the battery consumption (excluding regenerative braking) and energy recovered. However, the net battery consumption decreased. In addition, as the speed increased, the energy consumption increased in the order of urban, rural, and motorway sections owing to the air resistance and rolling resistance. Although the energy efficiency tended to increase with the regenerative braking stage, we observed that the real-world driving environment also had an impact. Therefore, in energy efficiency evaluation research, it is essential to analyze the results that reflect the various influencing factors in real-world driving environments and to verify the characteristics of each regenerative braking stage through chassis dynamometer tests. | Lee, Gwangryeol; Song, Jingeun; Han, Jungwon; Lim, Yunsung; Park, Suhan | Konkuk Univ, Grad Sch, Dept Mech Engn, 120 Neungdong Ro, Seoul 05029, South Korea; Kyungpook Natl Univ, Sch Automot Engn, Sangju 37224, South Korea; Natl Inst Environm Res, 42 Hwangyeong ro, Inchon 22869, South Korea; Korea Univ, Dept Mech Engn, 145 Anam ro, Seoul 02841, South Korea; Konkuk Univ, Sch Mech & Aerosp Engn, 120 Neungdong ro, Seoul 05029, South Korea; Konkuk Univ, Sch Mech Engn, 120 Neungdong Ro, Seoul 05029, South Korea | Park, Suhan/U-1639-2019; Song, Jingeun/MTG-2604-2025 | 58489505800; 56714139600; 58619019000; 55307517400; 23493335100 | suhanpark@konkuk.ac.kr; | ENERGY | ENERGY | 0360-5442 | 1873-6785 | 283 | SCIE | ENERGY & FUELS;THERMODYNAMICS | 2023 | 9 | 3.2 | 3.69 | 2025-06-25 | 26 | 33 | Electric vehicle (EV); Regenerative braking system (RBS); Real -world driving; Battery consumption; Energy efficiency; Controller area network (CAN) | RANKINE-CYCLE ORC; CONTROL STRATEGY; EFFICIENCY IMPROVEMENT; EVALUATION METHODOLOGY; MANAGEMENT-SYSTEM; CONTROL ALGORITHM; OPTIMIZATION; RECOVERY; ENGINES; RANGE | Battery consumption; Controller area network (CAN); Electric vehicle (EV); Energy efficiency; Real-world driving; Regenerative braking system (RBS) | Automobile drivers; Behavioral research; Chassis; Control system synthesis; Dynamometers; Energy utilization; Process control; Regenerative braking; Secondary batteries; Battery consumption; Chassis dynamometer tests; Controller area network; Controller-area network; Driving conditions; Electric vehicle; Energy-consumption; Real-world drivings; Regenerative braking system; Regenerative braking systems; acceleration; electric vehicle; energy efficiency; fuel consumption; instrumentation; motorway; Energy efficiency | English | 2023 | 2023-11-15 | 10.1016/j.energy.2023.128745 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synergetic effects of concurrent chronic exposure to a mixture of OCPs and high-fat diets on type 2 diabetes and beneficial effects of caloric restriction in female zebrafish | This study aimed to investigate the relationship among chronic exposure to a low concentration of organo-chlorine pesticides (OCPs), high-fat diet (HFD)-induced obesity, and caloric restriction in type 2 diabetes (T2D). Thus, female zebrafish were divided into four groups and treated for 12 weeks as follows: (i) negative control, (ii) HFD (obesity) control, (iii) obesity + a mixture of OCPs (OP), and (iv) obesity + a mixture of OCPs + caloric restriction (OPR). We then assessed T2D-related effects via hematological analysis, histopathology, mitochondrial evaluation, and multiomics analyses. The OP group showed a significant increase in glucose levels, whereas the OPR group maintained glucose at nonsignificant levels. Multiomics analyses revealed that the exacerbated metabolic effects in the OP group were associated with molecular alterations in oxidative stress, inflammation, nucleotide metabolism, and glucose/lipid homeostasis. These alterations were histologically verified by the increased numbers of hypertrophic adipocytes and inflammatory cells observed. Caloric re-striction activated pathways related to antioxidant response, mitochondrial fatty acid oxidation, and energy metabolism in zebrafish, leading to preserved glucose homeostasis. In conclusion, this study identified molecular mechanisms underlying the synergistic effect of concurrent exposure to a mixture of OCPs and HFD as well as shed light on the beneficial effect of regular caloric restriction in T2D development. | Lee, Hyojin; Gao, Yan; Kim, Jae Kwan; Shine, Sooim; Choi, Moonsung; Hwang, Youngja; Lee, Sangkyu; Rhyu, Dong Young; Kim, Ki-Tae | Seoul Natl Univ Sci & Technol, Dept Environm Engn, Seoul 01811, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Plus KNU Multi Based Creat Drug Res Team BK21, Daegu 41566, South Korea; Wuxi AppTec, Dept Core Analyt Serv, Shanghai 200131, Peoples R China; Korea Basic Sci Inst, Seoul 02841, South Korea; Chonnam Natl Univ, Dept Biotechnol & Bioengn, Gwangju 61186, South Korea; Seoul Natl Univ Sci & Technol, Dept Optometry, Seoul 01811, South Korea; Korea Univ, Coll Pharm, Metabol Lab, Sejong City 30019, South Korea; Kyungpook Natl Univ, Mass Spectrometry Based Convergence Res Inst, Daegu 41566, South Korea; Mokpo Natl Univ, Dept Biomed Hlth & Life Convergence Sci, BK21 FOUR, Jeonnam 58554, South Korea | ; KIM, KI-TAE/AAX-3175-2020 | 57200522840; 58736921100; 58036273300; 26435504000; 23396080300; 58036900200; 57209046767; 6508208340; 57202074566 | ktkim@seoultech.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 446 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 0.47 | 2025-06-25 | 4 | 5 | Zebrafish; Organochlorine pesticide mixtures; Type 2 diabetes; Obesity; Caloric restriction | PERSISTENT ORGANIC POLLUTANTS; OXIDATIVE STRESS; LIPID-METABOLISM; BIOMARKERS; DIVERGENT; COMPLEX; GLUCOSE; OBESITY | Caloric restriction; Obesity; Organochlorine pesticide mixtures; Type 2 diabetes; Zebrafish | Animals; Caloric Restriction; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Glucose; Obesity; Pesticides; Zebrafish; Fatty acids; Metabolism; Mitochondria; Nutrition; Pesticides; glucose; organochlorine derivative; organochlorine pesticide; pesticide; Beneficial effects; Caloric restriction; Chronic exposure; High-fat-diet; Obesity; Organochlorine pesticide mixture; Organochlorine pesticides; Pesticide mixture; Type-2 diabetes; Zebrafish; cyprinid; diabetes; fatty acid; female; obesity; organochlorine pesticide; pollution exposure; adipocyte; animal experiment; animal tissue; Article; caloric restriction; controlled study; diet-induced obesity; differential gene expression; drug potentiation; energy metabolism; fatty acid oxidation; female; glucose homeostasis; glucose level; histopathology; inflammation; inflammatory cell; lipid diet; lipid homeostasis; long term exposure; metabolomics; mitochondrion; multiomics; non insulin dependent diabetes mellitus; nonhuman; nucleotide metabolism; obesity; oxidative stress; physical parameters; proteomics; synergistic effect; transcriptomics; zebra fish; adverse event; animal; caloric restriction; lipid diet; metabolism; Glucose | English | 2023 | 2023-03-15 | 10.1016/j.jhazmat.2022.130659 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Thermal performance and energy cost of Korean multispan greenhouse energy-saving screens | Protected agricultural system such as a greenhouse cultivation is increasingly replacing traditional farming systems. Nonetheless, high energy demand in greenhouse farming requires innovative technologies through the use of climate screens to ensure sustainable production. Thus, this study developed a novel methodology for examining the energy retention capacity and economic effectiveness of greenhouse climate screen materials using their thermophysical, radiometric and aerodynamic properties in TRNSYS software. The TRNSYS model was developed to determine the energy consumption, which was validated using a multi-span Venlo-type experimental greenhouse (Yeoju, South Korea). Further analyses on energy saving capacity of different screens and the equivalent energy costs were performed. The results from this research showed that among the fifteen investigated screens, the ensemble screen (M3) saved 34.09 kWh.m(-2) of annual energy, equivalent to 60 % of the heating energy demand, and energy cost of 4490.26 Korean won. m(-2). Further, the results revealed that the climate screens with multi-layer, thermoreflective, low longwave transmissivity, impermeable and aluminized strips or surface characteristics and features have a considerable impact on reducing greenhouse energy use and desirable for high energy-saving. This research has demonstrated that the techniques and methods utilised can investigate all the types of covering and thermal screens used in greenhouse. | Rabiu, Anis; Adesanya, Misbaudeen Aderemi; Na, Wook-Ho; Ogunlowo, Qazeem O.; Akpenpuun, Timothy D.; Kim, Hyeon Tae; Lee, Hyun-Woo | Kyungpook Natl Univ, Coll Agr & Life Sci, Dept Agr Civil Engn, Daegu 702701, South Korea; Kyungpook Natl Univ, Smart Agr Innovat Ctr, Daegu 41566, South Korea; Univ Ilorin, Dept Agr & Biosyst Engn, PMB 1515, Ilorin, Nigeria; Gyeongsang Natl Univ, Dept Bioind Machinery Engn, Jinju 52828, South Korea | ; Adesanya, Misbaudeen/AAA-4664-2022; Akpenpuun, Timothy/AAE-1168-2020; OGUNLOWO, QAZEEM/ABB-5386-2021; RABIU, Anis/JXO-1947-2024 | 57264527100; 57264527200; 57211208368; 57265471800; 57194448083; 8662923200; 57209160180 | rabiuanis@knu.ac.kr;misbauadesanya@knu.ac.kr;wooks121@knu.ac.kr;ogunlowoqazeem@knu.ac.kr;akpenpuun.td@unilorin.edu.ng;bioani@gnu.ac.kr;whlee@knu.ac.kr; | ENERGY | ENERGY | 0360-5442 | 1873-6785 | 285 | SCIE | ENERGY & FUELS;THERMODYNAMICS | 2023 | 9 | 3.2 | 0.9 | 2025-06-25 | 7 | 8 | Climate screens properties; Greenhouse farming; Thermal performance; Energy saving; Energy cost; TRNSYS | HOT BOX METHOD; AIR PERMEABILITY; SOLAR; TRANSMITTANCE; SIMULATION; DESIGN; MODEL; HEAT | Climate screens properties; Energy cost; Energy saving; Greenhouse farming; Thermal performance; TRNSYS | South Korea; Cost benefit analysis; Cultivation; Energy management; Energy utilization; Farms; Greenhouses; Climate screen property; Energy savings; Energy cost; Energy-savings; Greenhouse energy; Greenhouse farming; Multi-spans; Property; Thermal Performance; TRNSYS; cultivation; energy efficiency; energy use; farming system; greenhouse ecosystem; heating; retention; Energy conservation | English | 2023 | 2023-12-15 | 10.1016/j.energy.2023.129514 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Three-directional engineering of IsPETase with enhanced protein yield, activity, and durability | The mesophilic PETase from Ideonella sakaiensis (IsPETase) has been shown to exhibit high PET hydrolysis activity, but its low stability limits its industrial applications. Here, we developed a variant, Z1-PETase, with enhanced soluble protein yield and durability while maintaining or improving activity at lower temperatures. The selected Z1-PETase not only exhibited a 20-fold improvement in soluble protein yield compared to the previously engineered IsPETase(S121E/D186H/S242T/N246D) (4p) variant, but also demonstrated a 30% increase in low-temperature activity at 40 degrees C, along with an 11 degrees C increase in its TmD value. The PET depolymerization test across a temperature range low to high (30-70.degrees C) confirmed that Z1-PETase exhibits high accessibility of mesophilic PET hydrolase and rapid depolymerizing rate at higher temperature in accordance with the thermal behaviors of polymer and enzyme. Additionally, structural interpretation indicated that the stabilization of specific active site loops in Z1-PETase contributes to enhanced thermostability without adversely impactingenzymatic activity. In a pH-stat bioreactor, Z1-PETase depolymerized > 90% of both transparent and colored post-consumer PET powders within 24 and 8 h at 40 degrees C and 55. C, respectively, demonstrating that the utility of this IsPETase variant in the bio-recycling of PET. | Lee, Seul Hoo; Seo, Hogyun; Hong, Hwaseok; Park, Jiyoung; Ki, Dongwoo; Kim, Mijeong; Kim, Hyung-Joon; Kim, Kyung-Jin | Kyungpook Natl Univ, Sch Life Sci, KNU Inst Microorganisms, BK21 FOUR KNU Creat Biores Grp, Daegu 41566, South Korea; CJ CheilJedang Co, Biores Res Inst, Suwon 16495, South Korea; Zyen Co, Daegu 41566, South Korea | Park, Jiyoung/MVY-3895-2025; Kim, Kyung-Jin/MVY-3405-2025 | 57205261937; 57189697998; 57208592877; 56188468900; 57219308133; 57360727100; 58080092600; 55510867400 | kkim@knu.ac.kr; | JOURNAL OF HAZARDOUS MATERIALS | J HAZARD MATER | 0304-3894 | 1873-3336 | 459 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES | 2023 | 12.2 | 3.2 | 1.42 | 2025-06-25 | 15 | 15 | PET hydrolase; Protein engineering; Durability; Thermostable; Ideonella sakaiensis | ENZYMATIC-HYDROLYSIS; POLY(ETHYLENE-TEREPHTHALATE); PETASE | Durability; Ideonella sakaiensis; PET hydrolase; Protein engineering; Thermostable | Bioreactors; Hydrolases; Hydrolysis; Polymers; Powders; Biochemical engineering; Durability; Polyethylene terephthalates; Temperature; hydrolase; polyethylene terephthalate; polymer; protein; hydrolase; Hydrolysis activity; Ideonellum sakaiensis; Lows-temperatures; Mesophilic; PET hydrolase; Protein engineering; Protein yield; Soluble proteins; Stability limit; Thermostable; bioreactor; enzyme activity; hydrolysis; polymer; protein; stabilization; temperature effect; Article; bacterium; comparative study; consumer; controlled study; decomposition; depolymerization; enzymatic hydrolysis; enzyme activity; enzyme stability; high temperature; Ideonella sakaiensis; low temperature; molecular dynamics; nonhuman; pH; protein engineering; protein function; site directed mutagenesis; thermal analysis; thermostability; hydrolysis; powder; Hydrolases | English | 2023 | 2023-10-05 | 10.1016/j.jhazmat.2023.132297 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Yam-derived exosome-like nanovesicles stimulate osteoblast formation and prevent osteoporosis in mice | Plants-releasing exosome-like nanovesicles (PENs) contain miRNA, bioactive lipids, mRNAs, and proteins to exert antioxidant, anti-inflammatory, and regenerative activity. Substances extracted from yams have been reported to promote osteoblast growth in bone regeneration, which prevent weak and brittle bones in osteoporosis. Herein, we describe the beneficial effects of yam-derived exosome-like nanovesicles (YNVs) on promoting differentiation and mineralization of osteoblasts for bone regeneration in ovariectomized (OVX)-induced osteoporotic mice. YNVs were successfully isolated and characterized. YNVs stimulate the proliferation, differentiation, and mineralization of osteoblasts with increased bone differentiation markers (OPN, ALP, and COL-I). Interestingly, YNVs do not contain saponins including diosgenin and dioscin known to mainly exert osteogenic activity of yams. Instead, the osteogenic activity of YNVs was revealed to be resulted from activation of the BMP-2/p-p38-dependent Runx2 pathway. As a result, YNVs promote longitudinal bone growth and mineral density of the tibia in the OVX-induced osteoporotic mice in vivo, and these results positively correlate the significant increases in osteoblast-related parameters. In addition, the orally administered YNVs were transported through the GI tract and absorbed through the small intestine. These results showed an excellent systemic biosafety determined by histological analysis and liver/kidney toxicity tests. Taken together, YNVs can serve as a safe and orally effective agent in the treatment of osteoporosis. | Hwang, Jin-Hyeon; Park, Yu-Seong; Kim, Hyuk-Soon; Dong-ha Kim; Lee, Sang-Hoon; Lee, Chan-Hyeong; Lee, Seung-Hoon; Kim, Jung-Eun; Lee, Sangkyu; Kim, Ho Min; Kim, Hyun-Woo; Kim, Jihoon; Seo, Wonhyo; Kwon, Hyo-Jung; Song, Byoung-Joon; Kim, Do-Kyun; Baek, Moon-Chang; Cho, Young-Eun | Andong Natl Univ, Dept Food & Nutr, Andong 36729, South Korea; Jeonbuk Natl Univ, Korea Zoonosis Res Inst, Iksan 54531, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu, South Korea; Dong A Univ, Dept Biomed Sci, Coll Nat Sci, Grad Sch, Busan 49315, South Korea; Dong A Univ, Dept Hlth Sci, Grad Sch, Busan 49315, South Korea; Inst Basic Sci IBS, Ctr Biomol & Cellular Struct, Daejeon 34126, South Korea; Yonsei Univ, Div Biol Sci & Technol, Wonju 26493, South Korea; Ewha Womans Univ, Coll Pharm, Grad Sch Pharmaceut Sci, Seoul 03760, South Korea; Chungnam Natl Univ, Coll Vet Med, Dept Vet Pathol, 99 Daehak Ro, Daejeon 34134, South Korea; NIAAA, Sect Mol Pharmacol & Toxicol, NIH, Bethesda, MD 20892 USA | kim, david/AAA-4537-2020; Wang, Xiaolin/ADQ-6971-2022; Kim, Hyuk Soon/IQW-9348-2023; Kim, Jihoon/GQP-4563-2022; Lee, Sangkyu/AAM-2198-2021 | 57219012305; 57242757000; 35770880400; 57219014701; 58067536200; 57189904697; 59056027600; 57209054588; 59911175800; 58122841900; 59656812200; 58091357200; 56335935100; 56658978200; 7402560465; 57442742600; 7006013097; 56390104900 | dkkim714@jbnu.ac.kr;mcbaek@knu.ac.kr;yecho@anu.ac.kr; | JOURNAL OF CONTROLLED RELEASE | J CONTROL RELEASE | 0168-3659 | 1873-4995 | 355 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2023 | 10.5 | 3.2 | 18.8 | 2025-06-25 | 122 | 121 | Exosome-like nanovesicles; Yam -derived nanovesicles; Bone mineral density; Osteoporosis | ALKALINE-PHOSPHATASE ACTIVITY; ACTIVATED PROTEIN-KINASE; DRUG-DELIVERY; EXTRACELLULAR VESICLES; CELL-DIFFERENTIATION; COLLAGEN-SYNTHESIS; BONE-FORMATION; PROLIFERATION; GROWTH; IDENTIFICATION | Bone mineral density; Exosome-like nanovesicles; Osteoporosis; Yam-derived nanovesicles | Animals; Cell Differentiation; Dioscorea; Exosomes; Mice; Osteoblasts; Osteogenesis; Osteoporosis; Bone; Diseases; Mammals; Mineralogy; alizarin red s; alkaline phosphatase; bone morphogenetic protein 2; diosgenin; isoprotein; messenger RNA; mitogen activated protein kinase p38; nanoparticle; protein ZO1; transcription factor RUNX2; unclassified drug; yam derived exosome like nanovesicle; Bone mineral density; Bone regeneration; Exosome-like nanovesicle; Exosomes; Mineralisation; Nanovesicle; Osteoporosis; Osteoporotic; Yam-derived nanovesicle; animal cell; animal experiment; animal model; Article; bone density; bone development; bone growth; bone matrix; bone regeneration; bone volume fraction; cell differentiation; cell organelle; cell proliferation; centrifugation; comparative study; controlled study; down regulation; electron microscopy; enzyme activity; exosome; extracellular matrix; female; immunoblotting; immunohistochemistry; in vitro study; in vivo study; KEGG; liver toxicity; male; MC3T3-E1 cell line; micro-computed tomography; mineralization; molecular size; morphometry; mouse; MTT assay; nephrotoxicity; nonhuman; ossification; osteoblast; osteolysis; osteoporosis; photon correlation spectroscopy; postmenopause osteoporosis; protein expression; proteomics; real time polymerase chain reaction; RNA sequencing; thin layer chromatography; tibia; ultracentrifugation; upregulation; yam; animal; metabolism; osteoblast; osteoporosis; RNA | English | 2023 | 2023-03 | 10.1016/j.jconrel.2023.01.071 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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