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○ | ○ | Article | AGK2 ameliorates mast cell-mediated allergic airway inflammation and fibrosis by inhibiting FcεRI/TGF-βsignaling pathway | Asthma is characterized by airway hyperresponsiveness and allergic inflammation, detrimentally affecting the patients' quality of life. The development of new drugs for the treatment of asthma is warranted to alleviate these issues. Recent studies have demonstrated that sirtuin2 (SIRT2) aggravates asthmatic inflammation by up-regulation of T-helper type 2 responses and macrophage polarization. However, effects of SIRT2 on mast cell activation remain obscure. In this study, we investigated the effects of AGK2, an inhibitor for SIRT2, on mast cell mediated allergic airway inflammation. Pre-treatment with AGK2 inhibited degranulation of mast cells by suppressing the Fc epsilon RI signaling pathway and intracellular calcium influx. The expression of pro-inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-4, IL-5, IL-6, and IL-8, was inhibited via regulation of transcription factors such as NF-kappa B and NRF2. These effects of AGK2 were verified in passive cutaneous anaphylaxis and acute lung injury animal models. AGK2 attenuated Evans blue pigmentation by inhibiting mast cell activation and lung barrier dysfunction by inhibiting inflammatory responses in these animal models. In the ovalbumin (OVA)-induced allergic airway inflammation murine model, AGK2 alleviated allergic asthma symptoms such as lung histological changes (immune cell and mast cell infiltration, collagen deposition, and alpha-smooth muscle actin expression) and serum immunoglobulins (Ig) levels (IgE, OVA-specific IgE, IgG1, and IgG2a). Moreover, AGK2 reduced the levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-4, IL-5, and IL-6) and inflammatory mediators (myeloperoxidase, eosinophil peroxidase, and tumor growth factor-alpha) in the bronchoalveolar lavage fluid and lung tissues. In addition, the anti-fibrotic effects of AGK2 were verified using lung epithelial cells and TGF-beta/Smad reporter stable cells. In conclusion, our findings suggest that SIRT2 plays a role in mast cell-mediated airway inflammatory disease. Therefore, AGK2 is a good potential candidate for treating allergic asthma and lung inflammation. | Kim, Yeon-Yong; Hur, Gayeong; Lee, Seung Woong; Lee, Seung-Jae; Lee, Soyoung; Kim, Sang-Hyun; Rho, Mun-Chual | Korea Res Inst Biosci & Biotechnol KRIBB, Immunoregulatory Mat Res Ctr, Jeongeup, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, CMRI, Daegu, South Korea | 57190027396; 57210110184; 55033843800; 59074953300; 8537269200; 57210450420; 56473737800 | sylee@kribb.re.kr;shkim72@knu.ac.kr;rho-m@kribb.re.kr; | PHARMACOLOGICAL RESEARCH | PHARMACOL RES | 1043-6618 | 159 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 7.658 | 5.6 | 1.85 | 2025-06-25 | 54 | 48 | Asthma; Airway inflammation; Mast cells; SIRT2; AGK2 | NF-KAPPA-B; SIRTUIN 2; TGF-BETA/SMAD; ASTHMA; INJURY; LUNG; RESPONSES; INSIGHTS; SUPPRESSION; PROGRESSION | AGK2; Airway inflammation; Asthma; Mast cells; SIRT2 | A549 Cells; Airway Remodeling; Animals; Anti-Asthmatic Agents; Asthma; Cell Degranulation; Cytokines; Disease Models, Animal; Female; Fibrosis; Furans; Histamine Release; Histone Deacetylase Inhibitors; Humans; Inflammation Mediators; Lung; Male; Mast Cells; Mice, Inbred BALB C; Mice, Inbred ICR; Passive Cutaneous Anaphylaxis; Quinolines; Rats, Sprague-Dawley; Receptors, IgE; Signal Transduction; Sirtuin 2; Transforming Growth Factor beta; agk 2; alpha smooth muscle actin; collagen; eosinophil peroxidase; immunoglobulin E; immunoglobulin E receptor; immunoglobulin enhancer binding protein; immunoglobulin G1; immunoglobulin G2a; interleukin 1beta; interleukin 4; interleukin 5; interleukin 6; interleukin 8; myeloperoxidase; respiratory tract agent; transcription factor Nrf2; transforming growth factor beta; tumor necrosis factor; unclassified drug; AGK2 compound; antiasthmatic agent; autacoid; cytokine; FcepsilonRIalpha protein, mouse; FCER1A protein, rat; furan derivative; histone deacetylase inhibitor; immunoglobulin E receptor; quinoline derivative; Sirt2 protein, mouse; Sirt2 protein, rat; sirtuin 2; transforming growth factor beta; allergic airway inflammation; animal cell; animal experiment; animal model; animal tissue; antifibrotic activity; Article; Bagg albino mouse; bronchoalveolar lavage fluid; calcium transport; cell activation; clinical effectiveness; controlled study; cytokine release; dose response; drug effect; drug efficacy; drug mechanism; female; histology; lung epithelium; lung fibrosis; lung parenchyma; male; mast cell; mast cell degranulation; mouse; nonhuman; priority journal; protein expression; rat; signal transduction; Sprague Dawley rat; treatment outcome; A-549 cell line; airway remodeling; animal; asthma; degranulation; disease model; drug effect; enzymology; fibrosis; histamine release; human; immunology; Institute for Cancer Research mouse; lung; mast cell; metabolism; passive skin anaphylaxis; pathophysiology | English | 2020 | 2020-09 | 10.1016/j.phrs.2020.105027 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
○ | ○ | Article | Comparison of 5 Different PET Radiopharmaceuticals for the Detection of Recurrent Medullary Thyroid Carcinoma A Network Meta-analysis | Purpose The aim of this study is to investigate and compare the performance of different PET radiopharmaceuticals for the detection of recurrent medullary thyroid carcinoma (MTC) by performing a network meta-analysis (NMA) using direct comparison studies with 2 or more PET radiopharmaceuticals. Methods PubMed and EMBASE were searched for the studies evaluating the performance of PET or PET/CT for the detection of recurrent MTC. The NMA was performed for different PET radiopharmaceuticals in both patient- and lesion-based analyses and with a threshold of serum calcitonin or carcinoembryonic antigen (CEA) levels and calcitonin doubling time. The consistency was evaluated by examining the agreement between direct and indirect treatment effects, and publication bias was assessed by funnel plot asymmetry tests. The surface under the cumulative ranking curve values were obtained to calculate the probability of each PET modality being the most effective diagnostic method. Results A total of 306 patients from 14 direct comparison studies using 5 different PET radiopharmaceuticals (F-18-FDG, F-18-DOPA, Ga-68-somatostatin analogs, 3-O-methyl-6-[F-18]fluoro-DOPA, and C-11-methionine) for the detection of recurrent MTC was included. The detection rate of F-18-DOPA PET was significantly higher than that of FDG PET in both patient- and lesion-based analyses (patient-based analysis: odds ratio, 2.44; 95% confidence interval, 1.4-4.31; lesion-based analysis: odds ratio, 5.74; 95% confidence interval, 1.65-23.4). Among all PET radiopharmaceuticals, F-18-DOPA showed the highest surface under the cumulative ranking curve value in both patient- and lesion-based analyses regardless of serum calcitonin or CEA levels and calcitonin doubling time. Conclusions The results from this NMA indicate that F-18-DOPA PET clearly showed a best performance for the detection of recurrent MTC in both patient- and lesion-based analyses regardless of serum calcitonin or CEA levels and calcitonin doubling time. | Lee, Sang-Woo; Shim, Sung Ryul; Jeong, Shin Young; Kim, Seong-Jang | Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Korea Univ, Dept Prevent Med, Coll Med, Seoul, South Korea; Soonchunhyang Univ Hosp, Urol Biomed Res Inst, Seoul, South Korea; Pusan Natl Univ, Dept Nucl Med, Yangsan Hosp, Yangsan, South Korea; Pusan Natl Univ, Coll Med, Dept Nucl Med, Yangsan, South Korea; Pusan Natl Univ, Yangsan Hosp, BioMed Res Inst Convergence Biomed Sci & Technol, Yangsan, South Korea | lee, sangwoo/KUD-1906-2024; shim, sungryul/D-3792-2016; Kim, Yun Hak/ABF-3331-2021 | 57196249819; 55072270800; 36164032500; 35810391700 | growthkim@daum.net; | CLINICAL NUCLEAR MEDICINE | CLIN NUCL MED | 0363-9762 | 1536-0229 | 45 | 5 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 7.794 | 5.6 | 3.04 | 2025-06-25 | 40 | 47 | FDG; F-18-DOPA; network meta-analysis; PET; recurrent; medullary thyroid carcinoma | POSITRON-EMISSION-TOMOGRAPHY; F-18-FDG PET; F-18-DOPA PET; CT; CALCITONIN | F-DOPA; FDG; medullary thyroid carcinoma; network meta-analysis; PET; recurrent | Adult; Carcinoma, Neuroendocrine; Female; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Thyroid Neoplasms; 3 o methyl 6 fluoro dopa f 18; 6 fluorodopa f 18; calcitonin; carcinoembryonic antigen; fluorodeoxyglucose f 18; methionine c 11; radiopharmaceutical agent; somatostatin ga 68; unclassified drug; radiopharmaceutical agent; Article; calcitonin blood level; cancer diagnosis; cancer recurrence; evidence based practice; human; intermethod comparison; meta analysis; network meta-analysis; positron emission tomography; positron emission tomography-computed tomography; practice guideline; systematic review; task performance; thyroid medullary carcinoma; adult; carcinoma; comparative study; diagnostic imaging; female; male; middle aged; procedures; thyroid tumor; tumor recurrence | English | 2020 | 2020-05 | 10.1097/rlu.0000000000002940 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Early-Phase ¹⁸F-Florbetaben PET as an Alternative Modality for ¹⁸F-FDG PET | Purpose: Based on the possibility that early-phase florbetaben (E-FBB) brain PET can be a surrogate for brain perfusion imaging, we conducted this study to investigate the clinical utility of E-FBB PET instead of F-18-FDG brain PET. Materials and Methods: This prospective study included 35 patients with clinical suspicion of cognitive decline or dementia and 5 healthy controls. BrainMRI, E-FBB PET, late-phase FBB PET, and FDG PETwere acquired. The regional SUV ratios (SUVRs) were calculated by cortical surface region of interest analysis using individual MRI, and relationship between E-FBB and FDG PETwas analyzed. All PET scanswere scored and analyzed as per visual scoring system, which represent tracer uptake abnormality. Moreover, uptake patterns were analyzed to determine the disease. Results: Among the 40 subjects, 19 were amyloid-positive and 21 were amyloid-negative on late-phase FBB PET. Cortical surface region of interest analysis conducted for comparing between E-FBB and FDG PETrevealed significant correlations (P < 0.0001) for regional SUVR among all brain regions; however, the SUVR values of FDG PETwere statistically higher than those of E-FBB PET. Similarly, although the visually rated scores for E-FBB and FDG PET showed significant correlation (P < 0.0001), it was considered that the tracer uptakewas more severely decreased for FDG PET. The disease types, specified by E-FBB and FDG PET, were statistically correlated. Conclusions: E-FBB PET could potentially be a useful biomarker for the diagnosis of dementia in place of FDG PET. Nevertheless, the severity of the disease was more accurately determined by FDG PET. | Son, Seung Hyun; Kang, Kyunghun; Ko, Pan-Woo; Lee, Ho-Won; Lee, Sang-Woo; Ahn, Byeong-Cheol; Lee, Jaetae; Yoon, Uicheul; Jeong, Shin Young | Kyungpook Natl Univ, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Neurol, Daegu, South Korea; Daegu Catholic Univ, Dept Biomed Engn, Hayang Ro 13-13, Gyongsan, Gyeongbuk, South Korea | Lee, Jaetae/ABF-3980-2020; lee, sangwoo/KUD-1906-2024; Yoon, Uicheul/AFG-0112-2022 | 56596907400; 55365592200; 55543341200; 35337240700; 57196249819; 7202791511; 7601451907; 7003570756; 36164032500 | yoonuc@cu.ac.kr;syjeong@knu.ac.kr; | CLINICAL NUCLEAR MEDICINE | CLIN NUCL MED | 0363-9762 | 1536-0229 | 45 | 1 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 7.794 | 5.6 | 1.3 | 2025-06-25 | 19 | 19 | florbetaben; PET; neuroimaging; beta-amyloid; cerebral blood flow | MILD COGNITIVE IMPAIRMENT; ALZHEIMERS ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DISEASE; BRAIN; DEMENTIA; RECOMMENDATIONS; REGISTRATION; ACTIVATION | cerebral blood flow; florbetaben; neuroimaging; PET; β-amyloid | Aged; Amyloid; Aniline Compounds; Brain; Case-Control Studies; Cognitive Dysfunction; Dementia; Female; Fluorodeoxyglucose F18; Humans; Male; Neuroimaging; Positron-Emission Tomography; Prospective Studies; Stilbenes; Time Factors; amyloid; florbetaben; fluorodeoxyglucose f 18; glucose; 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene; amyloid; aniline derivative; stilbene derivative; aged; Alzheimer disease; Article; brain perfusion; brain tissue; clinical article; comparative study; controlled study; degenerative disease; dementia; female; glucose blood level; human; image analysis; image processing; male; mild cognitive impairment; neuroimaging; nuclear magnetic resonance imaging; positron emission tomography; prospective study; standardized uptake value ratio; brain; case control study; clinical trial; cognitive defect; diagnostic imaging; metabolism; positron emission tomography; procedures; time factor | English | 2020 | 2020-01 | 10.1097/rlu.0000000000002768 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
○ | ○ | Article | Facile and accelerated production of RuO2 monolayers via a dual-step intercalation process | Tetrabutylammonium ions (TBA(+)) have commonly been used to exfoliate RuO2 into monolayers via ion exchange reactions. However, the low production yield of RuO2 exfoliation, which originates from the large molecular size of TBA(+), limits wider utilisation of RuO2 monolayers in optoelectronic applications. We introduce a rapid and efficient dual-step exfoliation process beginning with intercalation of small organic molecules (tetramethylammonium ions) into RuO2, which is followed by the addition of TBA(+) as a second intercalant to realize RuO2 monolayer production. Our dual-step intercalation process increases the RuO2 monolayer exfoliation yield from 9.9% to 60% after 14 days. Density functional theory calculations reveal that the activation energy of dual-step intercalation is much lower than that of direct intercalation of TBA(+) ions into the RuO2 structure. The experimental and theoretical results of dual-step intercalation suggest that it is a facile and general approach for the production of metal oxide monolayers, and could widen the use of metal oxide monolayer nanosheets. | Kim, Se Yun; Shin, Weon Ho; Jung, Doh Won; Ko, Dong-Su; Roh, Jong Wook; Hwang, Sungwoo; Lee, Jongmin; Lee, Kimoon; Park, Hee Jung; Kwak, Chan; Kim, Sang-il; Jeong, Hyung Mo; Lee, Kyu Hyoung; Kim, Hyun Sik | Samsung Adv Inst Technol, Inorgan Mat Lab, Suwon 16678, South Korea; Kwangwoon Univ, Dept Elect Mat Engn, Seoul 01897, South Korea; Samsung Adv Inst Technol, Autonomous Mat Dev Lab, Suwon 16678, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Sangju 37224, South Korea; Kunsan Natl Univ, Dept Phys, Gunsan 54150, South Korea; Dankook Univ, Dept Mat Sci & Engn, Cheonan 31116, South Korea; Univ Seoul, Dept Mat Sci & Engn, Seoul 02504, South Korea; Sungkyunkwan Univ, Sch Mech Engn, Suwon 16419, South Korea; Yonsei Univ, Dept Mat Sci & Engn, Seoul 03722, South Korea; Hongik Univ, Dept Mat Sci & Engn, Seoul 04066, South Korea | Ko, Dong-Su/AAZ-5644-2020; Kim, Seung/N-5248-2019; Shin, Weon/AAH-4031-2020; Kim, Sung/A-4747-2013 | 57203210313; 57204152565; 12804624000; 25641304500; 25638796100; 57208461223; 57204464367; 57222518881; 7601568847; 57193904846; 36171889900; 42061388000; 35205856800; 56526077500 | seyuni.kim@samsung.com;hyunsik.kim@hongik.ac.kr; | INORGANIC CHEMISTRY FRONTIERS | INORG CHEM FRONT | 2052-1553 | 7 | 6 | SCIE | CHEMISTRY, INORGANIC & NUCLEAR | 2020 | 6.569 | 5.6 | 0.44 | 2025-06-25 | 10 | 8 | CONDUCTIVITY; EXFOLIATION; NANOSHEETS; RUTHENATE; BEHAVIOR; LAYER | Activation energy; Density functional theory; Exfoliation (materials science); Ion exchange; Ions; Metals; Monolayers; Exfoliation process; Intercalation process; Ion exchange reactions; Optoelectronic applications; Production yield; Small organic molecules; Tetrabutylammonium; Tetramethylammonium ions; Ruthenium compounds | English | 2020 | 2020-03-21 | 10.1039/c9qi01678c | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
○ | ○ | Article | Growth and gas sensing properties of methylammonium tin iodide thin film | Methylammonium tin iodide (MASnI(3)) is a p-type semiconductor with excellent optical versus electrical properties. This work introduces a process for growing high-purity MASnI(3) thin films via thermal evaporation. The growth process of the MASnI(3) thin film was proposed and discussed. The gas sensing properties of the MASnI(3) thin film were investigated at room temperature with/without illumination. The film exhibited the highest selectivity toward NO2 (detection limit of 25 ppb). Furthermore, the sensing performance of the device was excellent comparing with those of recent NO2 sensing candidates. The gas sensing mechanism of the device was discussed. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | Vu Xuan Hien; Pham Tien Hung; Han, Jeongwoo; Lee, Sangwook; Lee, Joon-Hyung; Heo, Young-Woo | Kyungpook Natl Univ, Sch Mat Sci & Engn, E8-215,80 Daehakro, Daegu 41566, South Korea; Hanoi Univ Sci & Technol, Sch Engn Phys, 01 Dai Co Viet St, Hanoi, Vietnam; Kyungpook Natl Univ, Adv Mat Res Inst, Daegu 41566, Vietnam | Xuan, Hien/AAF-7020-2019; Hung, pham/ABF-3792-2021; Lee, Sangwook/O-9166-2015 | 54408588700; 57194216208; 59475446600; 57203597324; 57204923460; 7004298542 | joonlee@knu.ac.kr;ywheo@knu.ac.kr; | SCRIPTA MATERIALIA | SCRIPTA MATER | 1359-6462 | 178 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.611 | 5.6 | 1.1 | 2025-06-25 | 16 | 17 | Halide perovskite; Lead-free; Thin film; Gas sensor; CVD | REDUCED GRAPHENE OXIDE; HALIDE PEROVSKITES; NO2; PERFORMANCE; SENSOR; OXYGEN; ENHANCEMENT; STABILITY; HYBRIDS | CVD; Gas sensor; Halide perovskite; Lead-free; Thin film | Chemical detection; Chemical sensors; Chemical vapor deposition; Film growth; Gas detectors; Nitrogen oxides; Perovskite; Perovskite solar cells; Thermal evaporation; Tin compounds; Detection limits; Gas sensing mechanism; Gas sensing properties; Growth process; Halide perovskites; Lead-Free; P type semiconductor; Sensing performance; Thin films | English | 2020 | 2020-03 | 10.1016/j.scriptamat.2019.10.049 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Ilimaquinone inhibits neovascular age-related macular degeneration through modulation of Wnt/β-catenin and p53 pathways | Neovascular age-related macular degeneration (nAMD) is a common cause of irreversible vision loss in the elderly. Anti-vascular endothelial growth factor has been effective in treating pathological ocular neovascularization, but it has limitations including the need for repeated intraocular injections for the maintenance of therapeutic effects in most patients and poor or non-response to this agent in some patients. in vitro cellular studies were conducted using retinal pigment epithelial cell lines (ARPE-19 and hTERT-RPE1), human umbilical vein endothelial cells (HUVECs), and human umbilical vein smooth muscle cells (HUVSMCs). in vivo efficacy of ilimaquinone (IQ) was tested in laser-induced choroidal neovascularization mouse and rabbit models. Tissue distribution study was performed in male C57BL6/J mice. IQ, 4,9-friedodrimane-type sesquiterpenoid isolated from the marine sponge, repressed the expression of angiogenic/inflammatory factors and restored the expression of E-cadherin in retinal pigment epithelial cells by inhibiting the Wnt/beta-catenin pathway. In addition, it selectively inhibited proliferation and tube formation of HUVECs by activating the p53 pathway. Topical and intraperitoneal administration of IQ significantly reduced choroidal neovascularization in rabbits and mice with laser-induced choroidal neovascularization. Notably, IQ by the oral route of exposure was highly permeable to the eyes and suppressed abnormal vascular leakage by downregulation of beta-catenin and stabilization of p53 in vivo. Our findings demonstrate that IQ functions through regulation of p53 and Wnt/beta-catenin pathways with conceivable advantages over existing cytokine-targeted anti-angiogenic therapies. | Son, Younglim; Lim, Daehan; Park, Seoyoung; Song, Im-Sook; Kim, Joo-Hyun; Shin, Sora; Jang, Hoik; Liu, Kwang-Hyeon; Yuseok, O.; Song, Gyu-Yong; Kang, Wonku; Cho, Yun-Seok; Na, MinKyun; Chung, Hyewon; Oh, Sangtaek | Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Seoul 02707, South Korea; Konkuk Univ, Dept Ophthalmol, Sch Med, Seoul 05030, South Korea; Kyungpook Natl Univ, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu 41566, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; Hanlim Pharm Co Ltd, R&D Ctr, Seoul 06634, South Korea | na, ma/K-4873-2013 | 57189853647; 56389163800; 55700846800; 7201564500; 56092766700; 57208058588; 57218628359; 55768214700; 57189603607; 7402253074; 7202401591; 56449745700; 7006636995; 57191447230; 7404104398 | mkna@cnu.ac.kr;hchung@kuh.ac.kr;ohsa@kookmin.ac.kr; | PHARMACOLOGICAL RESEARCH | PHARMACOL RES | 1043-6618 | 1096-1186 | 161 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 7.658 | 5.6 | 0.44 | 2025-06-25 | 10 | 11 | Neovascular age-related macular degeneration; Ilimaquinone; Wnt/beta-catenin pathway; p53 pathway | TYROSINE KINASE INHIBITOR; MARINE SPONGE METABOLITES; WNT SIGNALING PATHWAY; BETA-CATENIN; CHOROIDAL NEOVASCULARIZATION; PATHOGENIC ROLE; ACTIVATION; ANGIOGENESIS; CELLS; RECEPTOR | Ilimaquinone; Neovascular age-related macular degeneration; p53 pathway; Wnt/β-catenin pathway | Angiogenesis Inhibitors; Animals; beta Catenin; Cell Line; Choroidal Neovascularization; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Macular Degeneration; Male; Mice, Inbred C57BL; Quinones; Rabbits; Retinal Neovascularization; Retinal Vessels; Sesquiterpenes; Tumor Suppressor Protein p53; Wnt Signaling Pathway; aflibercept; beta catenin; caspase 3; caspase 7; ilimaquinone; protein p53; sesquiterpenoid; unclassified drug; uvomorulin; Wnt protein; angiogenesis inhibitor; beta catenin; CTNNB1 protein, human; CTNNB1 protein, mouse; ilimaquinone; protein p53; quinone derivative; sesquiterpene; TP53 protein, human; Trp53 protein, mouse; animal experiment; animal model; animal tissue; apoptosis; Article; cell viability; controlled study; cytotoxicity; enzyme activation; enzyme inhibition; human; human cell; immunofluorescence; in vitro study; limit of quantitation; male; mouse; nonhuman; priority journal; protein expression; protein stability; real time polymerase chain reaction; retina pigment cell; smooth muscle cell; subretinal neovascularization; tissue distribution; umbilical vein endothelial cell; umbilical vein smooth muscle cell; Western blotting; wet macular degeneration; animal; C57BL mouse; cell line; disease model; drug effect; Leporidae; macular degeneration; metabolism; pathology; retina blood vessel; retina neovascularization; subretinal neovascularization; Wnt signaling | English | 2020 | 2020-11 | 10.1016/j.phrs.2020.105146 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Inflection of flow transition curves by magnetic effect in annulus and consequential bifurcation map in wide ranges of Rayleigh and Hartmann numbers | In this study, the bifurcation phenomenon of natural convection at a Prandtl number of 0.3 is analyzed for a circular magnetic field applied to an annulus of a diameter ratio of 2. Flows in the annulus have been categorized as upward and downward flows according to the flow patterns observed near the upper stagnation region of the annulus. In previous studies on the bifurcation of natural convection without magnetic effects, no bifurcation was observed at very low ( 45,000) Rayleigh conditions. However, the results presented here indicate the bifurcation can occur even at high Rayleigh conditions (> 45,000) under specific magnetic conditions. A bifurcation map was thus created over a range of Hartmann numbers from 0 to 20 and Rayleigh numbers from 3000 to 80,000 and the inflection of the transition lines was studied. As a result, the transition Rayleigh and Hartmann numbers and the critical Rayleigh and Hartmann numbers were redefined. | Usman, Muhammad; Lee, Jong Hui; Park, Il Seouk | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea | Lee, Jong Hui/JFT-0292-2023 | 57220670787; 57204669495; 50262800000 | einstein@knu.ac.kr; | INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER | INT COMMUN HEAT MASS | 0735-1933 | 1879-0178 | 118 | SCIE | MECHANICS;THERMODYNAMICS | 2020 | 5.683 | 5.6 | 0.24 | 2025-06-25 | 5 | 5 | Transition curve; Natural convection; Magnetohydrodynamics; Bifurcation map | NATURAL-CONVECTION FLOW; HORIZONTAL CYLINDRICAL ANNULUS; RECTANGULAR ENCLOSURE; NUMERICAL-SOLUTION; HEAT-TRANSFER; FIELD; CAVITY; PATTERNS; SILICON | Bifurcation map; Magnetohydrodynamics; Natural convection; Transition curve | Bifurcation (mathematics); Magnetism; Prandtl number; Bifurcation phenomena; Critical Rayleigh; Flow transitions; Hartmann numbers; Magnetic effects; Rayleigh number; Stagnation regions; Transition lines; Natural convection | English | 2020 | 2020-11 | 10.1016/j.icheatmasstransfer.2020.104889 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Machine learning-based prediction models for formation energies of interstitial atoms in HCP crystals | Prediction models of the formation energies of H, B, C, N, and O atoms in various interstitial sites of hcp-Ti, Zr, and Hf crystals are developed based on machine learning. Parametric models such as linear regression and brute force search (BFS) as well as nonparametric algorithms including the support vector regression (SVR) and the Gaussian process regression (GPR) are employed. Readily accessible chemical and geometrical descriptors allow straightforward implementation of the prediction models without any expensive computational modeling. The models based on BFS, SVR, and GPR show the excellent performance with R-2 > 96%. (C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | You, Daegun; Ganorkar, Shraddha; Kim, Sooran; Kang, Keonwook; Shin, Won-Yong; Lee, Dongwoo | Sungkyunkwan Univ, Sch Mech Engn, Suwon, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Phys Educ, Daegu, South Korea; Yonsei Univ, Dept Mech Engn, Seoul, South Korea; Yonsei Univ, Dept Computat Sci & Engn, Seoul, South Korea | ; Kang, Keonwook/AAE-4432-2021; Lee, Dongwoo/AAE-2099-2022 | 57205882405; 36909868700; 55146733200; 57217845791; 36830013700; 55960626200 | wy.shin@yonsei.ac.kr;dongwoolee@skku.edu; | SCRIPTA MATERIALIA | SCRIPTA MATER | 1359-6462 | 1872-8456 | 183 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.611 | 5.6 | 0.78 | 2025-06-25 | 17 | 17 | Formation energy; Interstitial atom; HCP crystal; Machine learning; First-principles calculation | AB-INITIO; NANOCALORIMETRY EXPERIMENTS; ZR; ELECTRONEGATIVITY; IMPURITIES; DIFFUSION; BEHAVIOR; ALLOYS; CARBON | First-principles calculation; Formation energy; HCP crystal; Interstitial atom; Machine learning | Atoms; Calculations; Crystals; Forecasting; Learning systems; Machine learning; Brute force search; Computational model; First-principles calculation; Formation energies; Gaussian process regression; Interstitial atoms; Non-parametric algorithm; Support vector regression (SVR); Support vector regression | English | 2020 | 2020-07-01 | 10.1016/j.scriptamat.2020.02.042 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Mitochondrial carnitine palmitoyltransferase 2 is involved in Nε-(carboxymethyl)-lysine-mediated diabetic nephropathy | Diabetic nephropathy (DN) is the most common cause of end-stage renal disease in the world. Advanced glycation end products (AGEs) are thought to be involved in the pathogenesis of DN via multifactorial mechanisms including the generation of oxidative stress and overproduction of various growth factors and cytokines. AGEs are heterogeneous cross-linked sugar-derived proteins, and N-epsilon-(carboxymethyl)-lysine (CML)-conjugated BSA is a major component of AGEs. However, the proteins involved in DN induction by CML have never been reported. Herein, we investigated specific protein regulators of AGE-mediated DN via proteomic analysis of streptozotocin (STZ)-induced diabetic mice kidneys. We identified 937, 976, and 870 proteins in control, STZ, and STZ + CML-BSA samples, respectively. Bioinformatics analysis identified several CML-mediated proteins potentially involved in kidney damage, activation of fatty acid oxidation (FAO), and mitochondrial dysfunction. Furthermore, we identified the CML-specific differential protein carnitine palmitoyltransferase 2 (CPT2), related to FAO. To confirm the effect of CPT2 and the CML-mediated mechanism, human renal tubular HK-2 cells were treated with CML-BSA and cpt2 siRNA, and examined for FAO-mediated fibrosis and mitochondrial dysfunction. CML-BSA and CPT2 knockdown induced fibrosis-related gene expression and damage to mitochondrial membrane potential. Moreover, CPT2 overexpression recovered CML-induced fibrosis-related gene expression. Based on these results, a decrease in CML-induced CPT2 expression causes mitochondrial FAO damage, leading to renal fibrosis and DN. | Lee, Jangho; Hyon, Ju-Yong; Min, Jin Young; Huh, Yang Hoon; Kim, Hyo Jung; Lee, Hayoung; Yun, Sung Ho; Choi, Chi-Won; Ha, Su Jeong; Park, Joon; Chung, Young-Ho; Jeong, Hye Gwang; Ha, Sang Keun; Jung, Sung Keun; Kim, YoonSook; Han, Eun Hee | KFRI, Jeollabuk Do 55365, South Korea; Korea Univ, Seoul 02841, South Korea; KBSI, Cheongju 28119, South Korea; Chungnam Natl Univ, Daejeon 34134, South Korea; Korea Univ Sci & Technol UST, Daejeon 34113, South Korea; KBNP Technol Inst, Anyang 14009, South Korea; Seoul Natl Univ, Seoul 08826, South Korea; Kyungpook Natl Univ, Daegu 41566, South Korea | Jung, SUNG KEUN/AGR-2623-2022; LEE, HAYOUNG/HJJ-6600-2023 | 56970755700; 57212509407; 57191499308; 7102963459; 57212505990; 57200636136; 59784195700; 59865196200; 57203586413; 57197793272; 26665287000; 55663373000; 56539262400; 35310491400; 34770894700; 8249465000 | skjung04@knu.ac.kr;kimyus@kfri.re.kr;heh4285@kbsi.re.kr; | PHARMACOLOGICAL RESEARCH | PHARMACOL RES | 1043-6618 | 1096-1186 | 152 | SCIE | PHARMACOLOGY & PHARMACY | 2020 | 7.658 | 5.6 | 1.32 | 2025-06-25 | 21 | 20 | Diabetic nephropathy (DN); End-stage renal disease; Advanced glycation end products; Mitochondrial dysfunction; N-epsilon-(carboxymethyl)-lysine; Carnitine palmitoyltransferase 2 | GLYCATION END-PRODUCTS; RENAL FIBROSIS; EXTRACELLULAR-MATRIX; LIPID DROPLETS; GROWTH-FACTOR; SERUM-LEVELS; MECHANISMS; EXPRESSION; ENDPRODUCTS; INSULIN | Advanced glycation end products; Carnitine palmitoyltransferase 2; Diabetic nephropathy (DN); End-stage renal disease; Mitochondrial dysfunction; N<sup>ε</sup>-(carboxymethyl)-lysine | Animals; Blood Glucose; Carnitine O-Palmitoyltransferase; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glycated Hemoglobin A; Humans; Kidney; Lysine; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria; 6 n carboxymethyllysine; advanced glycation end product; bovine serum albumin; carnitine palmitoyltransferase; carnitine palmitoyltransferase 2; glucose; hemoglobin A1c; mitochondrial enzyme; small interfering RNA; unclassified drug; carnitine palmitoyltransferase; glycosylated hemoglobin; lysine; N(6)-carboxymethyllysine; albuminuria; animal experiment; animal model; animal tissue; apoptosis; Article; bioinformatics; cell viability; controlled study; cytotoxicity assay; disease association; disorders of mitochondrial functions; fatty acid oxidation; gene expression; gene knockdown; gene overexpression; histopathology; HK-2 [Human kidney] cell line; human; human cell; immunoblotting; kidney fibrosis; liquid chromatography-mass spectrometry; male; mitochondrial membrane potential; mitochondrion; mouse; nonhuman; polyacrylamide gel electrophoresis; priority journal; protein analysis; proteomics; real time polymerase chain reaction; streptozotocin-induced diabetic nephropathy; transcriptomics; transmission electron microscopy; animal; C57BL mouse; cell line; diabetic nephropathy; enzymology; experimental diabetes mellitus; genetics; glucose blood level; insulin dependent diabetes mellitus; kidney; metabolism; pathology; physiology | English | 2020 | 2020-02 | 10.1016/j.phrs.2019.104600 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Multimode film boiling on a horizontal surface in a vertically oscillating system | Bubble departure frequency in film boiling on a stationary heating wall is in the order of a few hertz, which is interestingly the same as that for the natural frequency of a nuclear reactor building. Thus, the film boiling heat transfer of a nuclear fuel would be largely affected by system oscillation caused by low frequency earthquakes, and it is worth investigating the film boiling heat transfer for the heating wall in the oscillating system. To this end, multimode numerical simulations are performed for saturated film boiling on a horizontal surface in a system oscillating at low frequencies. There are three regimes in terms of heat transfer and bubble departure frequency. In the first regime, as the oscillation frequency increases, the heat transfer decreases while the bubble departure frequency remains nearly the same. In the second regime, as the oscillation frequency increases, the heat transfer decreases and the bubble departure frequency synchronizes with the oscillation frequency. In the third regime, as the oscillation frequency increases, the heat transfer increases and the bubble departure frequency synchronizes with the oscillation frequency. | An, Young Seock; Jo, Daeseong; Kim, Byoung Jae | Chungnam Natl Univ, Sch Mech Engn, 99 Daehak Ro, Daejeon 34134, South Korea; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea | Kim, Seonghwan/AAZ-1679-2021 | 57211390477; 16424303000; 58163399200 | bjkim@cnu.ac.kr; | INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER | INT COMMUN HEAT MASS | 0735-1933 | 1879-0178 | 119 | SCIE | MECHANICS;THERMODYNAMICS | 2020 | 5.683 | 5.6 | 0.32 | 2025-06-25 | 6 | 6 | Film boiling; Heat transfer; Oscillating system; Earthquake | NUMERICAL-SIMULATION; WATER; MODEL | Earthquake; Film boiling; Heat transfer; Oscillating system | Evaporation; Heat transfer; Nuclear fuels; Nuclear reactors; Walls (structural partitions); Bubble departure frequencies; Horizontal surfaces; Low-frequency earthquakes; Nuclear reactor buildings; Oscillating systems; Oscillation frequency; Saturated films; System oscillation; Oscillating flow | English | 2020 | 2020-12 | 10.1016/j.icheatmasstransfer.2020.104964 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Room-temperature NO2 sensor based on a hybrid nanomaterial of methylammonium tin iodide submicron spheres and tin dioxide nanowires | Perovskite halide materials are currently attracting considerable attention owing to their superior optical and electrical properties. This study proposes a reliable process for synthesizing hybrid nanomaterials made of methylammonium tin iodide (MASnI(3)) submicron spheres and tin dioxide (SnO2) nanowires. Post-fabricated hybrid nanomaterials were investigated for NO2 sensing properties at 25 degrees C in the dark. The effect of moisture on the NO2 sensitivity of this material was investigated. The durability of sensor components using this material was also investigated. In this paper, we also discuss the NO2 sensitivity mechanism of MASnI(3)/SnO2 hybrid nanomaterials in detail. (C) 2020 Published by Elsevier Ltd on behalf of Acta Materialia Inc. | Vu Xuan Hien; Phung Dinh Hoat; Pham Tien Hung; Lee, Sangwook; Lee, Joon-Hyung; Heo, Young-Woo | Hanoi Univ Sci & Technol HUST, Sch Engn Phys, 1 Dai Co Viet St, Hanoi, Vietnam; Le Quy Don Tech Univ, Sch Phys, Hanoi, Vietnam; Kyungpook Natl Univ KNU, Sch Mat Sci & Engn, E8-215,80 Daehakro, Daegu 702701, South Korea; Kyungpook Natl Univ, KNU Adv Mat Res Inst, Daegu 41566, South Korea | Xuan, Hien/AAF-7020-2019; Lee, Sangwook/O-9166-2015 | 54408588700; 57209732166; 57194216208; 57203597324; 57204923460; 7004298542 | ywheo@knu.ac.kr; | SCRIPTA MATERIALIA | SCRIPTA MATER | 1359-6462 | 188 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.611 | 5.6 | 1.02 | 2025-06-25 | 19 | 21 | Halide perovskite; Lead free; Hybrid material; CVD; Gas sensor | HALIDE PEROVSKITE; GAS SENSORS; SENSING PROPERTIES; THIN-FILM; OXYGEN | CVD; Gas sensor; Halide perovskite; Hybrid material; Lead free | Nanostructured materials; Nanowires; Nitrogen oxides; Perovskite; Hybrid nanomaterials; NO2 sensors; Optical and electrical properties; Sensing property; Sensitivity mechanisms; Sensor components; Submicron; Tin-iodide; Tin dioxide | English | 2020 | 2020-11 | 10.1016/j.scriptamat.2020.07.022 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
○ | ○ | Article | Tailored joint fabrication process derived ultra-low resistance MgB2 superconducting joint | We report an ultra-low resistance superconducting joint using unreacted multifilament MgB2 wires produced by tailoring the powder compaction pressure within the joint with heat treatment conditions. The joint demonstrated an ultra-low resistance of 5.48 x 10(-15) Omega and critical current (I-c) of 91.3 A at 20 K in self-field. The microstructural and composition studies of the joint revealed cracks and a high amount of MgO, respectively. These two features reduced the I-c of the joint to some extent; nevertheless, the joint resistance was not affected by it. Our tailored joining process will play a pivotal role in the superconducting joints development. (C) 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. | Patel, Dipak; Matsumoto, Akiyoshi; Kumakura, Hiroaki; Nishijima, Gen; Maeda, Minoru; Kim, Su-Hun; Choi, Seyong; Kim, Jung Ho | NIMS, 1-2-1 Sengen, Tsukuba, Ibaraki 3050047, Japan; Kangwon Natl Univ, Dept Elect Engn, Kangwon 25913, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea; Univ Wollongong, Australian Inst Innovat Mat, Inst Superconducting & Elect Mat, North Wollongong, NSW 2500, Australia | KUMAKURA, Hiroaki/H-2526-2011; MATSUMOTO, Akiyoshi/H-2765-2011; Kim, Jung Ho/D-4097-2014; Kim, Su-Hun/AAB-5569-2020; Maeda, Minoru/AAB-5589-2020; Choi, Seyong/AAB-5572-2020; Patel, Dipak/G-8293-2014; Nishijima, Gen/B-8804-2009 | 26040989200; 7403108130; 35459081100; 7003828099; 35426900700; 57188669953; 7408122787; 35215131600 | matsumoto.akiyoshi@nims.go.jp; | SCRIPTA MATERIALIA | SCRIPTA MATER | 1359-6462 | 1872-8456 | 178 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 5.611 | 5.6 | 0.94 | 2025-06-25 | 20 | 18 | MgB2 conductor; Superconducting joint; Persistent-mode operation; Closed-loop coil; MRI application | WIRES | Closed-loop coil; MgB<sub>2</sub> conductor; MRI application; Persistent-mode operation; Superconducting joint | Magnesia; Closed loops; Composition study; Fabrication process; Heat treatment conditions; MgB2 conductors; Persistent mode; Powder compactions; Superconducting joints; Heat resistance | English | 2020 | 2020-03 | 10.1016/j.scriptamat.2019.11.020 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | Review | Whispering gallery modes in triple microdisks of triangular configurations | We study whispering gallery modes in triple microdisks of equilateral and isosceles triangular configurations. The characteristic properties of resonant modes in three microdisks on the vertices of an equilateral triangle are explained by the discrete rotational symmetry of the triangle. The avoided crossings of resonant modes in three microdisks on the vertices of an isosceles triangle also are studied in terms of a combination of single and coupled microdisks. In addition, we propose matrix models that well explain the resonant modes in triple microdisks. © 2020 Optical Society of America | Ryu, Jung-Wan; Rim, Sunghwan | Center for Theoretical Physics of Complex Systems, Institute for Basic Science (IBS), Daejeon, 34126, South Korea; Digital Technology Research Center, Kyungpook National University, Daegu, 41566, South Korea | 12768616200; 7005692465 | jungwanryu@gmail.com; | Optica | OPTICA | 2334-2536 | 2334-2536 | 7 | 8 | SCIE | OPTICS | 2020 | 11.104 | 5.6 | 0.54 | 2025-06-25 | 29 | Optical resonators; Avoided crossings; Characteristic properties; Equilateral triangles; Isosceles triangular; Matrix model; Resonant mode; Rotational symmetries; Triangular configuration; Whispering gallery modes | English | Final | 2020 | 10.1364/optica.395825 | 바로가기 | 바로가기 | 바로가기 | ||||||||
○ | ○ | Article | Electrochemical crystallization for phosphate recovery from an electronic industry wastewater effluent using sacrificial iron anodes | With the circular economy in mind, recovery of iron phosphate, i.e., ferric phosphate or ferrous phosphate, from industrial wastewater is realized and the products recovered could be used in the synthesis of lithium iron phosphate for Li-ion secondary batteries. The formation of iron phosphate highly depends on pH and dissolved oxygen (DO) level. The present study focused on the phosphorus removal and recovery from the industrial wastewater effluent of a semiconductor plant by crystallization of iron phosphate. P recovery as iron phosphate was explored by means of electrochemical crystallization using a sacrificial iron anode under various DO levels (air sparging, mechanical mixing, and N-2 purging) and pH values (both initial and fixed pH). Under the nitrogen purging condition, the P removal linearly increased with increasing of the Fe:P molar ratios, reaching 100% when the Fe:P molar ratio equals 1.5, which is the stoichiometric molar ratio of ferrous phosphate. The ferrous phosphate particles quickly settled and the crystalline structure was confirmed as vivianite. The final product obtained at pH 6.0 was composed of 82 wt% of vivianite. The operational cost of the electrochemical process was estimated to be only 23.5% of the costs required by the fluidized chemical crystallization process reported in the literature. (C) 2020 Elsevier Ltd. All rights reserved. | Martin, Natacha; Ya, Vinh; Leewiboonsilp, Nattapong; Choo, Kwang-Ho; Noophan, Pongsak (Lek); Li, Chi-Wang | Tamkang Univ, Dept Water Resources & Environm Engn, 151 Yingzhuan Rd, New Taipei 25137, Taiwan; Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 702701, South Korea; Kasetsart Univ, Fac Engn, Dept Environm Engn, Bangkok 10900, Thailand | Li, Chi-Wang/G-1254-2015; Choo, Kwang-Ho/A-3456-2016 | 57200100544; 57195685175; 57219183429; 7102083272; 6506612491; 56621869300 | chiwang@mail.tku.edu.tw; | JOURNAL OF CLEANER PRODUCTION | J CLEAN PROD | 0959-6526 | 1879-1786 | 276 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2020 | 9.297 | 5.7 | 1.26 | 2025-06-25 | 49 | 49 | Electrochemical crystallization; Electronic industry; Iron phosphate; Phosphate recovery; Vivianite | STRUVITE PRECIPITATION; PHOSPHORUS REMOVAL; AQUEOUS-SOLUTIONS; CR(VI) REDUCTION; ELECTROCOAGULATION; VIVIANITE; FE | Electrochemical crystallization; Electronic industry; Iron phosphate; Phosphate recovery; Vivianite | Anodes; Chemicals removal (water treatment); Dissolved oxygen; Effluents; Electronics industry; Fluidization; Lithium compounds; Lithium-ion batteries; Metal recovery; Molar ratio; Nitrogen removal; Phosphate minerals; Secondary recovery; Crystalline structure; Crystallization process; Electrochemical crystallization; Electrochemical process; Industrial wastewaters; Li-ion secondary batteries; Lithium iron phosphates; Phosphorus removal and recoveries; Iron compounds | English | 2020 | 2020-12-10 | 10.1016/j.jclepro.2020.124234 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
○ | ○ | Article | Evaluating recycling potential of demolition waste considering building structure types: A study in South Korea | This study investigates the recycling potential of demolition waste (DW) according to building structure, while considering environmental and economic aspects For that, this study surveyed 1,034 residential buildings in Korea immediately before demolition to collect reliable information on demolition waste generation rates (DWGRs). This study classified the removal stages of buildings into the demolition, collection and sorting, transportation, and disposal stages. This study suggested a method for carbon emissions calculation for each stage and carried out an inventory analysis. The economic value of recycled DW materials was also calculated. Furthermore, the recycling potential was calculated based on the economic value and the environmental load for the current scenario, i.e., the current waste recycling rate in Korea, and the maximum scenario, i.e., the maximum theoretical recycling rate. Regarding building structures, the recycling potential of wooden structures was the highest in both the scenarios. However, masonry-block structures showed improved recycling potential in the maximum scenario. Regarding DW types, the recycling potential of plastics was the highest, with plastics from reinforced concrete (RC) structures showing 6.6 times higher recycling potential than those from wooden structures. And the possibility of improving the recycling potential was higher for glass and plastics than aggregates, timber, and metals. Through the above research, this paper devised an approach that can be used to plan a detailed construction and demolition waste management strategy, considering building structures and DW types, and this method can also be applied to other regions and countries. (C) 2020 Elsevier Ltd. All rights reserved. | Cha, Gi-Wook; Moon, Hyeun Jun; Kim, Young-Chan; Hong, Won-Hwa; Jeon, Gyu-Yeob; Yoon, Young Ran; Hwang, Changha; Hwang, Jung-Ha | Dankook Univ, Dept Architectural Engn, 152 Jukjeon Ro, Yongin 16890, South Korea; Hanyang Univ, Innovat Durable Bldg & Infrastruct Res Ctr, 55 Hanyangdaehak Ro, Ansan 426791, South Korea; Kyungpook Natl Univ, Sch Architecture Civil Environm & Energy Engn, 80 Daehak Ro, Daegu 41566, South Korea; Jeju Natl Univ, Dept Architectural Engn, 102 Jejudaehak Ro, Jeju Si 63243, Jeju Special Se, South Korea; Dankook Univ, Dept Appl Stat, 152 Jukjeon Ro, Yongin 16890, South Korea; Kyungpook Natl Univ, Sch Architecture, 80 Daehak Ro, Daegu 41566, South Korea | Yoon, Young-Ran/GLT-0172-2022 | 55754413300; 24559146700; 56463201400; 7401527968; 24335039900; 35753779600; 8340228700; 55710714500 | honjunmoon@gmail.com; | JOURNAL OF CLEANER PRODUCTION | J CLEAN PROD | 0959-6526 | 1879-1786 | 256 | SCIE | ENGINEERING, ENVIRONMENTAL;ENVIRONMENTAL SCIENCES;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2020 | 9.297 | 5.7 | 1.37 | 2025-06-25 | 36 | 41 | Demolition waste; Waste generation rate; Building structure; Recycling potential; Environmental effect; Economic value | LIFE-CYCLE ASSESSMENT; ENVIRONMENTAL-ANALYSIS; CONSTRUCTION; GENERATION; ENERGY; MODEL; PORTUGAL; SYSTEM; PLANT | Building structure; Demolition waste; Economic value; Environmental effect; Recycling potential; Waste generation rate | Demolition; Elastomers; Environmental impact; Plastics; Reinforced concrete; Waste management; Wooden buildings; Building structure; Demolition wastes; Economic values; Recycling potential; Waste generation rates; Plastic recycling | English | 2020 | 2020-05-20 | 10.1016/j.jclepro.2020.120385 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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