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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Do households conserve electricity when they receive signals of greater consumption than neighbours? The Korean case | This study examines whether households are encouraged to conserve electricity when their monthly utility statements indicate that their electricity usage is higher than that of their neighbours. A difference-in-differences analysis for 1161 Korean apartment households from 2016 to 2017 shows that the conservation effect appears only for those in medium-sized housing units. An eye-tracking experiment suggests a reason for this limited conservation effect: the average gazing time for the section of the statement that compares electricity usage across neighbouring households is lesser than the gazing time for other sections, indicating little interest in the information. We discuss this in the context of shared mental models that can guide people to consider social norms as context for their individual energy usage. (c) 2021 Elsevier Ltd. All rights reserved. | Choi, Sunghee; Hwang, Seok-Joon; Denzau, Arthur T. | Keimyung Univ, Fac Econ & Commerce, 1095 Dalgubeoldaero, Daegu, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Int Trade, 80 Daehakro, Daegu, South Korea; Claremont Graudate Univ, Fac Econ, Claremont Inst Econ Policy Studies, 150 E 10th St, Claremont, CA 91711 USA | Hwang, Seok-Joon/R-6225-2019 | 55523591700; 49061139500; 6506501442 | choisu@kmu.ac.kr; | ENERGY | ENERGY | 0360-5442 | 1873-6785 | 225 | SCIE | ENERGY & FUELS;THERMODYNAMICS | 2021 | 8.857 | 4.0 | 0.26 | 2025-07-30 | 5 | 5 | Neighbour-comparison information; Residential electricity conservation; Difference-in-difference analysis; Eye-tracking experiment; Shared mental model | EYE-MOVEMENTS; SOCIAL NORMS; PERCEPTION; GOAL | Difference-in-difference analysis; Eye-tracking experiment; Neighbour-comparison information; Residential electricity conservation; Shared mental model | Korea; Cognitive systems; Electric power utilization; Housing; Conservation effects; Difference-in-difference analyse; Difference-in-differences; Differences-in-differences; Electricity usage; Eye-tracking experiment; Housing units; Neighbor-comparison information; Residential electricity conservation; Shared mental model; electricity generation; energy efficiency; energy use; experimental study; household structure; residential energy; signal; Eye tracking | English | 2021 | 2021-06-15 | 10.1016/j.energy.2021.120292 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke | Objective To test whether autologous modified mesenchymal stem cells (MSCs) improve recovery in patients with chronic major stroke. Methods In this prospective, open-label, randomized controlled trial with blinded outcome evaluation, patients with severe middle cerebral artery territory infarct within 90 days of symptom onset were assigned, in a 2:1 ratio, to receive preconditioned autologous MSC injections (MSC group) or standard treatment alone (control group). The primary outcome was the score on the modified Rankin Scale (mRS) at 3 months. The secondary outcome was to further demonstrate motor recovery. Results A total of 39 and 15 patients were included in the MSC and control groups, respectively, for the final intention-to-treat analysis. Mean age of patients was 68 (range 28-83) years, and mean interval between stroke onset to randomization was 20.2 (range 5-89) days. Baseline characteristics were not different between groups. There was no significant difference between the groups in the mRS score shift at 3 months (p = 0.732). However, secondary analyses showed significant improvements in lower extremity motor function in the MSC group compared to the control group (change in the leg score of the Motricity Index, p = 0.023), which was notable among patients with low predicted recovery potential. There were no serious treatment-related adverse events. Conclusions IV application of preconditioned, autologous MSCs with autologous serum was feasible and safe in patients with chronic major stroke. MSC treatment was not associated with improvements in the 3-month mRS score, but we did observe leg motor improvement in detailed functional analyses. Classification of Evidence This study provides Class III evidence that autologous MSCs do not improve 90-day outcomes in patients with chronic stroke. | Chung, Jong-Won; Chang, Won Hyuk; Bang, Oh Young; Moon, Gyeong Joon; Kim, Suk Jae; Kim, Soo-Kyoung; Lee, Jin Soo; Sohn, Sung-Il; Kim, Yun-Hee | Sungkyunkwan Univ, Samsung Med Ctr, Dept Neurol, Seoul, South Korea; Samsung Med Ctr, Translat & Stem Cell Res Lab Stroke, Seoul, South Korea; Samsung Med Ctr, Stem Cell & Regenerat Med Inst, Seoul, South Korea; Sungkyunkwan Univ, Heart Vasc Stroke Inst, Samsung Med Ctr, Ctr Prevent & Rehabil,Sch Med,Dept Phys & Rehabil, Seoul, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Sch Life Sci, Daegu, South Korea; Gyeongsang Natl Univ, Sch Med, Dept Neurol, Jinju, South Korea; Ajou Univ Hosp, Sch Med, Dept Neurol, Suwon, South Korea; Keimyung Univ, Sch Med, Dongsan Med Ctr, Dept Neurol, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Stem Cell Ctr,Asan Inst Life Sci, Seoul, South Korea; Univ Ulsan, Asan Med Ctr, Coll Med, Dept Convergence Med, Seoul, South Korea | ; Moon, Gyeong/P-7878-2019; Kim, Yun-Hee/GVS-6426-2022 | 55553751200; 35301717900; 7006620221; 8323365700; 26432031800; 57051653200; 55963063300; 36479287000; 57020121600 | ohyoung.bang@samsung.com; | NEUROLOGY | NEUROLOGY | 0028-3878 | 1526-632X | 96 | 7 | SCIE | CLINICAL NEUROLOGY | 2021 | 12.258 | 4.0 | 10.7 | 2025-07-30 | 130 | 132 | CLINICALLY IMPORTANT DIFFERENCE; STROMAL CELLS; RECOVERY; SERUM; TRANSPLANTATION; ALGORITHM; CORD | Adult; Aged; Aged, 80 and over; Female; Humans; Ischemic Stroke; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Middle Aged; Recovery of Function; Treatment Outcome; adult; adverse event; aged; brain ischemia; controlled study; convalescence; female; human; male; mesenchymal stem cell; mesenchymal stem cell transplantation; middle aged; randomized controlled trial; treatment outcome; very elderly | English | 2021 | 2021-02-16 | 10.1212/wnl.0000000000011440 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Global Impact of COVID-19 on Stroke Care and IV Thrombolysis | Objective To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months. | Nogueira, Raul G.; Qureshi, Muhammad M.; Abdalkader, Mohamad; Martins, Sheila Ouriques; Yamagami, Hiroshi; Qiu, Zhongming; Mansour, Ossama Yassin; Sathya, Anvitha; Czlonkowska, Anna; Tsivgoulis, Georgios; Aguiar de Sousa, Diana; Demeestere, Jelle; Mikulik, Robert; Vanacker, Peter; Siegler, James E.; Korv, Janika; Biller, Jose; Liang, Conrad W.; Sangha, Navdeep S.; Zha, Alicia M.; Czap, Alexandra L.; Holmstedt, Christine Anne; Turan, Tanya N.; Ntaios, George; Malhotra, Konark; Tayal, Ashis; Loochtan, Aaron; Ranta, Annamarei; Mistry, Eva A.; Alexandrov, Anne W.; Huang, David Y.; Yaghi, Shadi; Raz, Eytan; Sheth, Sunil A.; Mohammaden, Mahmoud H.; Frankel, Michael; Bila Lamou, Eric Guemekane; Aref, Hany M.; Elbassiouny, Ahmed; Hassan, Farouk; Menecie, Tarek; Mustafa, Wessam; Shokri, Hossam M.; Roushdy, Tamer; Sarfo, Fred S.; Alabi, Tolulope Oyetunde; Arabambi, Babawale; Nwazor, Ernest O.; Sunmonu, Taofiki Ajao; Wahab, Kolawole; Yaria, Joseph; Mohammed, Haytham Hussein; Adebayo, Philip B.; Riahi, Anis D.; Ben Sassi, Samia; Gwaunza, Lenon; Ngwende, Gift Wilson; Sahakyan, David; Rahman, Aminur; Ai, Zhibing; Bai, Fanghui; Duan, Zhenhui; Hao, Yonggang; Huang, Wenguo; Li, Guangwen; Li, Wei; Liu, Ganzhe; Luo, Jun; Shang, Xianjin; Sui, Yi; Tian, Ling; Wen, Hongbin; Wu, Bo; Yan, Yuying; Yuan, Zhengzhou; Zhang, Hao; Zhang, Jun; Zhao, Wenlong; Zi, Wenjie; Leung, Thomas W.; Chugh, Chandril; Huded, Vikram; Menon, Bindu; Pandian, Jeyaraj Durai; Sylaja, P. N.; Usman, Fritz Sumantri; Farhoudi, Mehdi; Hokmabadi, Elyar Sadeghi; Horev, Anat; Reznik, Anna; Hoffmann, Rotem Sivan; Ohara, Nobuyuki; Sakai, Nobuyuki; Watanabe, Daisuke; Yamamoto, Ryoo; Doijiri, Ryosuke; Tokuda, Naoki; Yamada, Takehiro; Terasaki, Tadashi; Yazawa, Yukako; Uwatoko, Takeshi; Dembo, Tomohisa; Shimizu, Hisao; Sugiura, Yuri; Miyashita, Fumio; Fukuda, Hiroki; Miyake, Kosuke; Shimbo, Junsuke; Sugimura, Yusuke; Yagita, Yoshiki; Takenobu, Yohei; Matsumaru, Yuji; Yamada, Satoshi; Kono, Ryuhei; Kanamaru, Takuya; Yamazaki, Hidekazu; Sakaguchi, Manabu; Todo, Kenichi; Yamamoto, Nobuaki; Sonoda, Kazutaka; Yoshida, Tomoko; Hashimoto, Hiroyuki; Nakahara, Ichiro; Kondybayeva, Aida; Faizullina, Kamila; Kamenova, Saltanat; Zhanuzakov, Murat; Baek, Jang-Hyun; Hwang, Yangha; Lee, Jin Soo; Lee, Si Baek; Moon, Jusun; Park, Hyungjong; Seo, Jung Hwa; Seo, Kwon-Duk; Sohn, Sung Il; Young, Chang Jun; Ahdab, Rechdi; Zaidi, Wan Asyraf Wan; Aziz, Zariah Abdul; bin Basri, Hamidon; Chung, Law Wan; Ibrahim, Aznita Binti; Ibrahim, Khairul Azmi; Looi, Irene; Tan, Wee Yong; Yahya, Nafisah Wan; Groppa, Stanislav; Leahu, Pavel; Al Hashmi, Amal M.; Imam, Yahia Zakaria; Akhtar, Naveed; Pineda-Franks, Maria Carissa; Co, Christian Oliver; Kandyba, Dmitriy; Alhazzani, Adel; Al-Jehani, Hosam; Tham, Carol Huilian; Mamauag, Marlie Jane; Venketasubramanian, Narayanaswamy; Chen, Chih-Hao; Tang, Sung-Chun; Churojana, Anchalee; Akil, Esref; Aykac, Ozlem; Ozdemir, Atilla Ozcan; Giray, Semih; Hussain, Syed Irteza; John, Seby; Huynh Le Vu; Anh Duc Tran; Huy Hoang Nguyen; Thong Nhu Pham; Thang Huy Nguyen; Trung Quoc Nguyen; Gattringer, Thomas; Enzinger, Christian; Killer-Oberpfalzer, Monika; Bellante, Flavio; De Blauwe, Sofie; Vanhooren, Geert; De Raedt, Sylvie; Dusart, Anne; Lemmens, Robin; Ligot, Noemie; Rutgers, Matthieu Pierre; Yperzeele, Laetitia; Alexiev, Filip; Sakelarova, Teodora; Bedekovic, Marina Roje; Budincevic, Hrvoje; Cindric, Igor; Hucik, Zlatko; Ozretic, David; Saric, Majda Seferovic; Pfeifer, Frantisek; Karpowic, Igor; Cernik, David; Sramek, Martin; Skoda, Miroslav; Hlavacova, Helena; Klecka, Lukas; Koutny, Martin; Vaclavik, Daniel; Skoda, Ondrej; Fiksa, Jan; Hanelova, Katerina; Nevsimalova, Miroslava; Rezek, Robert; Prochazka, Petr; Krejstova, Gabriela; Neumann, Jiri; Vachova, Marta; Brzezanski, Henryk; Hlinovsky, David; Tenora, Dusan; Jura, Rene; Jurak, Lubomir; Novak, Jan; Novak, Ales; Topinka, Zdenek; Fibrich, Petr; Sobolova, Helena; Volny, Ondrej; Christensen, Hanne Krarup; Drenck, Nicolas; Iversen, Helle Klingenberg; Simonsen, Claus Z.; Truelsen, Thomas Clement; Wienecke, Troels; Vibo, Riina; Gross-Paju, Katrin; Toomsoo, Toomas; Antsov, Katrin; Caparros, Francois; Cordonnier, Charlotte; Dan, Maria; Faucheux, Jean-Marc; Mechtouff, Laura; Eker, Omer; Lesaine, Emilie; Ondze, Basile; Peres, Roxane; Pico, Fernando; Piotin, Michel; Pop, Raoul; Rouanet, Francois; Gubeladze, Tatuli; Khinikadze, Mirza; Lobjanidze, Nino; Tsiskaridze, Alexander; Nagel, Simon; Ringleb, Peter Arthur; Rosenkranz, Michael; Schmidt, Holger; Sedghi, Annahita; Siepmann, Timo; Szabo, Kristina; Thomalla, Goetz; Palaiodimou, Lina; Sagris, Dimitrios; Kargiotis, Odysseas; Klivenyi, Peter; Szapary, Laszlo; Tarkanyi, Gabor; Adami, Alessandro; Bandini, Fabio; Calabresi, Paolo; Frisullo, Giovanni; Renieri, Leonardo; Sangalli, Davide; Pirson, Anne; Uyttenboogaart, Maarten; van den Wijngaard, Ido; Kristoffersen, Espen Saxhaug; Brola, Waldemar; Fudala, Malgorzata; Horoch-Lyszczarek, Ewa; Karlinski, Michal; Kazmierski, Radoslaw; Kram, Pawel; Rogoziewicz, Marcin; Kaczorowski, Rafal; Luchowski, Piotr; Sienkiewicz-Jarosz, Halina; Sobolewski, Piotr; Fryze, Waldemar; Wisniewska, Anna; Wiszniewska, Malgorzata; Ferreira, Patricia; Ferreira, Paulo; Fonseca, Luisa; Marto, Joao Pedro; Pinho e Melo, Teresa; Nunes, Ana Paiva; Rodrigues, Miguel; Cruz, Vitor Tedim; Falup-Pecurariu, Cristian; Krastev, Georgi; Mako, Miroslav; Alonso de Lecinana, Maria; Arenillas, Juan F.; Ayo-Martin, Oscar; Cruz Culebras, Antonio; Diez Tejedor, Exuperio; Montaner, Joan; Perez-Sanchez, Soledad; Tola Arribas, Miguel Angel; Rodriguez Vasquez, Alejandro; Mayza, Michael; Bernava, Gianmarco; Brehm, Alex; Machi, Paolo; Fischer, Urs; Gralla, Jan; Michel, Patrik L.; Psychogios, Marios-Nikos; Strambo, Davide; Banerjee, Soma; Krishnan, Kailash; Kwan, Joseph; Butt, Asif; Catanese, Luciana; Demchuk, Andrew M.; Field, Thalia; Haynes, Jennifer; Hill, Michael D.; Khosravani, Houman; Mackey, Ariane; Pikula, Aleksandra; Saposnik, Gustavo; Scott, Courtney Anne; Shoamanesh, Ashkan; Shuaib, Ashfaq; Yip, Samuel; Barboza, Miguel A.; Domingo Barrientos, Jose; Portillo Rivera, Ligia Ibeth; Gongora-Rivera, Fernando; Novarro-Escudero, Nelson; Blanco, Anmylene; Abraham, Michael; Alsbrook, Diana; Altschul, Dorothea; Alvarado-Ortiz, Anthony J.; Bach, Ivo; Badruddin, Aamir; Barazangi, Nobl; Brereton, Charmaine; Castonguay, Alicia; Chaturvedi, Seemant; Chaudry, Saqib A.; Choe, Hana; Choi, Jae H.; Dharmadhikari, Sushrut; Desai, Kinjal; Devlin, Thomas G.; Doss, Vinodh T.; Edgell, Randall; Etherton, Mark; Farooqui, Mudassir; Frei, Don; Gandhi, Dheeraj; Grigoryan, Mikayel; Gupta, Rishi; Hassan, Ameer E.; Helenius, Johanna; Kaliaev, Artem; Kaushal, Ritesh; Khandelwal, Priyank; Khawaja, Ayaz M.; Khoury, Naim N.; Kim, Benny S.; Kleindorfer, Dawn O.; Koyfman, Feliks; Lee, Vivien H.; Leung, Lester Y.; Linares, Guillermo; Linfante, Italo; Lutsep, Helmi L.; Macdougall, Lisa; Male, Shailesh; Malik, Amer M.; Masoud, Hesham; McDermott, Molly; Mehta, Brijesh P.; Min, Jiangyong; Mittal, Manoj; Morris, Jane G.; Multani, Sumeet S.; Nahab, Fadi; Nalleballe, Krishna; Nguyen, Claude B.; Novakovic-White, Roberta; Ortega-Gutierrez, Santiago; Rahangdale, Rahul H.; Ramakrishnan, Pankajavalli; Romero, Jose Rafael; Rost, Natalia; Rothstein, Aaron; Ruland, Sean; Shah, Ruchir; Sharma, Malveeka; Silver, Brian; Simmons, Marc; Singh, Abhishek; Starosciak, Amy K.; Strasser, Sheryl L.; Szeder, Viktor; Teleb, Mohamed; Tsai, Jenny P.; Voetsch, Barbara; Balaguera, Oscar; Pujol Lereis, Virginia A.; Luraschi, Adriana; Almeida, Marcele Schettini; Cardoso, Fabricio Buchdid; Conforto, Adriana; Silva, Leonardo De Deus; Giacomini, Luidia Varrone; Lima, Fabricio Oliveira; Longo, Alexandre L.; Magalhaes, Pedro S. C.; Martins, Rodrigo Targa; Mont'alverne, Francisco; Mora Cuervo, Daissy Liliana; Rebello, Leticia Costa; Valler, Lenise; Zetola, Viviane Flumignan; Lavados, Pablo M.; Navia, Victor; Olavarria, Veronica V.; Almeida Toro, Juan Manuel; Ricardo Amaya, Pablo Felipe; Bayona, Hernan; Corredor, Angel; Rivera Ordonez, Carlos Eduardo; Mantilla Barbosa, Diana Katherine; Lara, Osvaldo; Patino, Mauricio R.; Diaz Escobar, Luis Fernando; Melgarejo Farina, Donoband Edson Dejesus; Cardozo Villamayor, Analia; Zelaya Zarza, Adolfo Javier; Barrientos Iman, Danny Moises; Rodriguez Kadota, Liliana; Campbell, Bruce; Hankey, Graeme J.; Hair, Casey; Kleinig, Timothy; Ma, Alice; Martins, Rodrigo Tomazini; Sahathevan, Ramesh; Thijs, Vincent; Salazar, Daniel; Wu, Teddy Yuan-Hao; Haussen, Diogo C.; Liebeskind, David; Yavagal, Dileep R.; Jovin, Tudor G.; Zaidat, Osama O.; Nguyen, Thanh N. | Emory Univ, Sch Med, Dept Neurol,Grady Mem Hosp, Marcus Stroke & Neurosci Ctr, Atlanta, GA 30322 USA; Boston Univ, Sch Med, Boston Med Ctr, Dept Radiol, Boston, MA 02215 USA; Boston Univ, Sch Med, Boston Med Ctr, Dept Radiat Oncol, Boston, MA 02215 USA; Univ Fed Rio Grande do Sul, Dept Neurol, Porto Alegre, RS, Brazil; Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil; Natl Hosp Org Osaka Natl Hosp, Dept Stroke Neurol, Osaka, Japan; Army Med Univ, Xinqiao Hosp, Dept Neurol, Chongqing, Peoples R China; Alexandria Univ, Alexandria Univ Hosp, Stroke & Neurointervent Div, Dept Neurol, Alexandria, Egypt; Boston Univ, Sch Med, Boston, MA 02215 USA; Inst Psychiat & Neurol, Dept Neurol 2, Warsaw, Poland; Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Sch Med, Dept Neurol, Athens, Greece; Univ Lisbon, Fac Med, Lisbon, Portugal; Leuven Univ Hosp, Dept Neurol, Leuven, Belgium; St Annes Univ Hosp, Int Clin Res Ctr, Brno, Czech Republic; St Annes Univ Hosp, Dept Neurol, Brno, Czech Republic; Masaryk Univ, Fac Med, Brno, Czech Republic; Groeninge Hosp, Dept Neurol, Kortrijk, Belgium; Univ Hosp Antwerp, Dept Neurol, Antwerp, Belgium; Univ Antwerp, Dept Translat Neurosci, Antwerp, Belgium; Cooper Univ Hosp, Cooper Neurol Inst, Dept Neurol, Camden, NJ USA; Univ Tartu, Dept Neurol & Neurosurg, Tartu, Estonia; Loyola Univ Chicago, Stritch Sch Med, Dept Neurol, Chicago, IL USA; Kaiser Permanente Fontana Med Ctr, Dept Neurosurg, Fontana, CA USA; Kaiser Permanente Los Angeles Med Ctr, Dept Neurol, Los Angeles, CA USA; UT Hlth McGovern Med Sch, Dept Neurol, Houston, TX USA; Med Univ South Carolina, Dept Neurol, Charleston, SC 29425 USA; Univ Thessaly, Sch Hlth Sci, Dept Internal Med, Larisa, Greece; Allegheny Hlth Network, Dept Neurol, Pittsburgh, PA USA; Ohio Hlth Riverside Methodist Hosp Columbus, Dept Neurol, Columbus, OH USA; Univ Otago, Dept Med & Neurol, Wellington, New Zealand; Wellington Hosp, Wellington, New Zealand; Vanderbilt Univ, Med Ctr, Dept Neurol, Nashville, TN USA; Univ Tennessee, Ctr Hlth, Dept Neurol, Memphis, TN USA; Univ N Carolina, Dept Neurol, Chapel Hill, NC 27515 USA; NYU, Grossman Sch Med, Dept Neurol, New York, NY 10003 USA; NYU, Grossman Sch Med, Dept Radiol, New York, NY 10003 USA; Univ Douala, Fac Med & Pharmaceut Sci, Douala Gynaecoobstet & Pediat Hosp, Douala, Cameroon; Ain Shams Univ Specialized Hosp, Cairo, Egypt; Cairo Univ, Affiliated MOH Network, Cairo, Egypt; Nasser Inst Res & Treatment, Dept Neurol, Cairo, Egypt; Mansoura Univ, Affiliated Private Hosp Network, Mansoura, Egypt; Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana; Univ Ilorin Teaching Hosp, Stroke Unit, Ilorin, Nigeria; Lagos State Univ Teaching Hosp, Dept Med, Neurol Unit, Lagos, Nigeria; Fed Med Ctr Owerri, Dept Med, Owerri, Imo State, Nigeria; Fed Med Ctr, Dept Med, Owo, Ondo State, Nigeria; Univ Coll Hosp, Ibadan, Nigeria; Natl Ribat Univ, Affiliated Hosp, Khartoum, Sudan; Aga Khan Univ, Neurol Sect, Dept Internal Med, Med Coll East Africa, Dar Es Salaam, Tanzania; Tunis El Manar Univ, Mil Hosp Tunis, Tunis, Tunisia; Univ Tunis El Manar, Mongi Ben Hmida Natl Inst Neurol, Fac Med Tunis, Dept Neurol, Tunis, Tunisia; Parirenyatwa Hosp, Dept Physiol, Harare, Zimbabwe; Univ Zimbabwe, Dept Physiol, Harare, Zimbabwe; Univ Zimbabwe, Dept Med, Harare, Zimbabwe; Erebouni Med Ctr, Dept Cerebrovasc, Endovasc Neurosurg Div, Yerevan, Armenia; Sir Salimulah Coll, Dept Neurol, Dhaka, Bangladesh; Taihe Hosp Shiyan City, Dept Neurol, Shiyan, Hubei, Peoples R China; Nanyang Cent Hosp, Dept Neurol, Nanyang, Henan, Peoples R China; Wuhan 1 Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China; Zhejiang Univ, Sch Med, Sir Run Run Shaw Hosp, Dept Neurol, Hangzhou, Zhejiang, Peoples R China; Tradit Chinese Med Hosp Maoming, Dept Neurol, Maoming, Guangdong, Peoples R China; Qingdao Univ, Affiliated Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China; Hainan Med Coll, Affiliated Hosp 1, Dept Neurol, Haikou, Hainan, Peoples R China; Wuhan Cent Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China; Mianyang 404 Hosp, Dept Neurol, Mianyang, Sichuan, Peoples R China; Wannan Med Coll, Yijishan Hosp, Dept Neurol, Wuhu, Anhui, Peoples R China; Shenyang Med Coll, Affiliated Brain Hosp, Shenyang Peoples Hosp 1, Dept Neurol & Neurosci,Shenyang Brain Inst, Shenyang, Peoples R China; Qingdao Univ, Affiliated Yantai Yuhuangding Hosp, Dept Neurol, Qingdao, Shandong, Peoples R China; Xiangyang Cent Hosp, Dept Neurol, Xiangyang, Hubei, Peoples R China; Sichuan Univ, West China Hosp, Dept Neurol, Chengdu, Peoples R China; Southwest Med Univ, Affiliated Hosp, Dept Neurol, Luzhou, Sichuan, Peoples R China; Zhejiang Univ, Sch Med, Affiliated Hangzhou Peoples Hosp 1, Dept Neurol, Hangzhou, Zhejiang, Peoples R China; Shandong First Med Univ, Affiliated Hosp 1, Dept Neurol, Tai An, Shandong, Peoples R China; Fujian Med Univ, Affiliated Hosp 1, Dept Neurol, Fuzhou, Fujian, Peoples R China; Chinese Univ Hong Kong, Prince Wales Hosp, Kwok Tak Seng Ctr Stroke Res & Intervent, Acute Stroke Unit, Hong Kong, Peoples R China; MAX Superspecialty Hosp, Intervent Neurol, New Delhi, India; NH Mazumdar Shaw Med Ctr, NH Inst Neurosci, Bangalore, Karnataka, India; Apollo Special Hosp Nellore, Dept Neurol, Nellore, India; Christian Med Coll & Hosp, Dept Neurol, Ludhiana, Punjab, India; Sree Chitra Tirunal Inst Med Sci & Technol, Thiruvananthapuram, Kerala, India; Pelni Hosp, Stroke Unit, Jakarta, Indonesia; Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran; Beer Sheva Hosp, Beer Sheva, Israel; Rambam Healthcare Campus, Dept Intervent Neuroradiol, Haifa, Israel; Kobe City Med Ctr Gen Hosp, Dept Neurol, Kobe, Hyogo, Japan; Kobe City Med Ctr Gen Hosp, Dept Neurosurg, Kobe, Hyogo, Japan; IMS Tokyo Katsushika Gen Hosp, Dept Stroke & Neurovasc Surg, Katsushika, Japan; Yokohama Brain & Spine Ctr, Yokohama, Kanagawa, Japan; Iwate Prefectural Cent, Morioka, Iwate, Japan; Japanese Red Cross Kyoto Daiichi Hosp, Dept Neurol & Stroke Treatment, Kyoto, Japan; Kyoto Second Red Cross Hosp, Dept Neurol, Kyoto, Japan; Japanese Red Cross Kumamoto Hosp, Dept Neurol, Kumamoto, Japan; Kohnan Hosp, Dept Stroke Neurol, Sendai, Miyagi, Japan; Saga Ken Med Ctr, Dept Cerebrovasc Med, Saga, Japan; Saitama Med Ctr, Dept Neurol, Kawagoe, Saitama, Japan; Nara City Hosp, Dept Neurol, Nara, Japan; Toyonaka City Hosp, Dept Neurol, Osaka, Japan; Kagoshima City Hosp, Dept Neurol, Kagoshima, Japan; Japanese Red Cross Matsue Hosp, Dept Neurol, Matsue, Shimane, Japan; Shiroyama Hosp, Dept Neurol, Osaka, Japan; Niigata City Gen Hosp, Dept Cerebrovasc Med, Niigata, Japan; Sugimura Hosp, Dept Neurol, Kumamoto, Japan; Kawasaki Med Sch, Stroke Med, Okayama, Japan; Osaka Red Cross Hosp, Dept Neurol, Osaka, Japan; Univ Tsukuba, Dept Stroke Prevent & Treatment, Dept Neurosurg, Tsukuba, Ibaraki, Japan; Saiseikai Cent Hosp, Dept Neurol, Stroke Ctr & Neuroendovasc Therapy, Tokyo, Japan; Kin Ikyo Chuo Hosp, Dept Neurol, Sapporo, Hokkaido, Japan; NTT Med Ctr Tokyo, Dept Cerebrovasc Med, Tokyo, Japan; Yokohama Shintoshi Neurosurg Hosp, Dept Neurol & Neuroendovasc Treatment, Yokohama, Kanagawa, Japan; Osaka Gen Med Ctr, Dept Neurol, Osaka, Japan; Osaka Univ Hosp, Dept Neurol, Osaka, Japan; Tokushima Univ Hosp, Dept Adv Brain Res, Tokushima, Japan; Saiseikai Fukuoka Gen Hosp, Dept Neurol, Fukuoka, Japan; Tane Gen Hosp, Dept Neurol, Osaka, Japan; Osaka Rosai Hosp, Div Stroke, Dept Internal Med, Osaka, Japan; Fujita Hlth Univ, Sch Med, Dept Comprehens Stroke, Toyoake, Aichi, Japan; Asfendiyarov Kazakh Natl Med Univ, Dept Neurol, Alma Ata, Kazakhstan; Minist Hlth Republ Kazakhstan, Republican Ctr eHlth, Astana, Kazakhstan; Al Farabi Kazakh Natl Univ, Dept Med, Alma Ata, Kazakhstan; Kazakh Russian Med Univ, Alma Ata, Kazakhstan; Sungkyunkwan Univ, Sch Med, Kangbuk Samsung Hosp, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Ajou Univ Hosp, Suwon, South Korea; Catholic Univ Korea, Uijeongbu St Marys Hosp, Coll Med, Dept Neurol, Uijongbu, South Korea; Natl Med Ctr, Dept Neurol, Seoul, South Korea; Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Neurol, Daegu, South Korea; Inje Univ, Busan Paik Hosp, Sch Med, Dept Neurol, Busan, South Korea; Natl Hlth Insurance Serv Ilsan Hosp, Dept Neurol, Goyang, South Korea; Asan Med Ctr, Seoul, South Korea; LAU Med Ctr Rizk Hosp, Dept Neurol, Beirut, Lebanon; Pusat Perubatan Univ Kebangsaan Malaysia, Dept Med, Kuala Lumpur, Malaysia; Sultanah Nur Zahirah, Kuala Terengganu, Malaysia; Univ Putra Malaysia, Serdang, Malaysia; Sarawak Gen Hosp, Kuching, Malaysia; Hosp Sultan Abdul Halim, Sungai Petani Kedah, Malaysia; Hosp Seberang Jaya, George Town, Malaysia; Thomson Hosp Kota Damansara, Petaling Jaya, Malaysia; Nicolae Testemitanu State Univ Med & Pharm, Kishinev, Moldova; Emergency Med Inst, Dept Neurol, Kishinev, Moldova; Royal Hosp Muscat, Dept Stroke Unit, Muscat, Oman; Hamad Med Corp, Neurosci Inst, Doha, Qatar; St Lukes Med Ctr, Inst Neurosci, Quezon City, Philippines; St Petersburg Dzhanelidze Res Inst Emergency Med, Endovasc Neurosurg, St Petersburg, Russia; King Saud Univ, Dept Neurol, Coll Med, Stroke Unit, Riyadh, Saudi Arabia; Imam Abdulrahman bin Faisal Univ, King Fahad Hosp Univ, Dept Neurosurg, Intervent Radiol & Crit Care Med, Dammam, Saudi Arabia; Singapore Natl Neurosci Inst, Singapore, Singapore; Changi Gen Hosp, Singapore, Singapore; Raffles Hosp, Neurosci Ctr, Singapore, Singapore; Natl Taiwan Univ Hosp, Dept Neurol, Taipei, Taiwan; Mahidol Univ, Siriraj Hosp, Fac Med, Dept Radiol, Bangkok, Thailand; Dicle Univ, Med Sch & Hosp, Diyarbakir, Turkey; Eskisehir Osmangazi Univ, Stroke & Neurointervent Unit, Eskisehir, Turkey; Gaziantep Univ, Fac Med, Gaziantep, Turkey; Cleveland Clin Abu Dhabi, Neurol Inst, Dept Neurol, Abu Dhabi, U Arab Emirates; Hue Cent Hosp, Stroke Ctr, Hue, Vietnam; Da Nang Hosp, Stroke Dept, Da Nang City, Vietnam; 115 Peoples Hosp, Ho Chi Minh City, Vietnam; Med Univ Graz, Dept Neurol, Graz, Austria; Paracelsus Med Univ, Univ Hosp Salzburg, Res Inst Neurointervent, Dept Neurol, Salzburg, Austria; Ctr Hosp Univ Charleroi, Dept Neurol, Charleroi, Belgium; Sint Jan Hosp, Dept Neurol, Brugge, Belgium; UZ Brussel Brussels Univ Hosp, Dept Neurol, Brussels, Belgium; ULB Erasme Hosp Brussels, Dept Neurol, Brussels, Belgium; Europe Hosp Brussels, Dept Neurol, Brussels, Belgium; Antwerp Univ Hosp, Dept Neurol, Antwerp, Belgium; St Anna Univ Hosp, Neurol Clin, Sofia, Bulgaria; Sestre Milosrdnice Univ Hosp, Dept Neurol, Zagreb, Croatia; Sveti Duh Univ Hosp, Dept Neurol, Zagreb, Croatia; Gen Hosp Virovitica, Dept Neurol, Virovitica, Croatia; Gen Hosp Zabok, Dept Neurol, Zabok, Croatia; Univ Hosp Ctr Zagreb, Dept Radiol, Zagreb, Croatia; Reg Hosp Karlovy Vary, Karlovy Vary, Czech Republic; Masaryk Hosp Usti Nad Labem, Usti Nad Labem, Czech Republic; Mil Univ Hosp Praha, Prague, Czech Republic; Oblastni Nemocnice Nachod, Nachod, Czech Republic; Reg Hosp Pribram, Pribram, Czech Republic; Municipal Hosp Ostrava, Ostrava, Czech Republic; Hosp Mlada Boleslav, Mlada Boleslav, Czech Republic; Hosp Vitkovice, Ostrava, Czech Republic; Hosp Jihlava, Jihlava, Czech Republic; Gen Univ Praha, Prague, Czech Republic; Hosp Litomysl, Litomysl, Czech Republic; Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic; Hosp Pisek, Pisek, Czech Republic; Hosp Uherske Hradiste, Uherske Hradiste, Czech Republic; Hosp Prostejov, Prostejov, Czech Republic; Reg Hosp Chomutov, Chomutov, Czech Republic; Hosp Teplice, Teplice, Czech Republic; Min Hosp Karvina, Karvina, Czech Republic; Thomayer Hosp Praha, Prague, Czech Republic; Hosp Blansko, Blansko, Czech Republic; Univ Hosp Brno, Brno, Czech Republic; Reg Hosp Liberec, Liberec, Czech Republic; Hosp Ceska Lipa, Ceska Lipa, Czech Republic; Hosp Sokolov, Sokolov, Czech Republic; Reg Hosp Kolin, Kolin, Czech Republic; Hosp Trutnov, Trutnov, Czech Republic; Hosp Trinec, Trinec, Czech Republic; Masaryk Univ, Univ Hosp Ostrava, Fac Med, Dept Neurol, Brno, Czech Republic; Univ Copenhagen, Bispebjerg Hosp, Copenhagen, Denmark; Univ Copenhagen, Rigshosp, Stroke Ctr, Copenhagen, Denmark; Aarhus Univ Hosp, Aarhus, Denmark; Univ Copenhagen, Zealand Univ Hosp, Neurovasc Ctr, Roskilde, Denmark; Univ Tartu, Dept Neurol & Neurosurg, Tartu, Estonia; West Tallinn Cent Hosp, Neurol Clin, Tallinn, Estonia; Tallinn Univ, Sch Nat Sci & Hlth, East Tallinn Cent Hosp, Ctr Neurol, Tallinn, Estonia; Parnu Hosp, Internal Med Clin, Parnu, Estonia; Univ Lille, INSERM, CHU Lille, Lille Neurosci & Cognit, Lille, France; Ctr Hosp Arcachon, Gujan Mestras, France; Ctr Hosp Agen, Agen, Lot & Garonne, France; Hop Pierre Wertheimer, Hosp Civils Lyon, Neurol Vasc, Bron, France; Hop Pierre Wertheimer, Hosp Civils Lyon, Neuroradiol, Bron, France; CHU Bordeaux, Bordeaux, France; Ctr Hosp Mt de Marsan, Mt De Marsan, France; Fdn Ophtalmol Adolphe de Rothschild, Neurol, Paris, France; Versailles St Quentin En Yvelines Univ, Versailles, France; Fdn Ophtalmol Adolphe de Rothschild, Neuroradiol Intervent, Paris, France; Hop Univ Strasbourg, Neuroradiol Intervent, Strasbourg, France; K Eristavi Natl Ctr Expt & Clin Surg, Tbilisi, Georgia; New Vis Univ Hosp, Dept Neurosurg, Tbilisi, Georgia; Vivamedi Med Ctr, Tbilisi, Georgia; Pineo Med Ecosyst, Tbilisi, Georgia; Ivane Javakhishvili Tbilisi State Univ, Tbilisi, Georgia; Univ Hosp Heidelberg, Dept Neurol, Heidelberg, Germany; Albertinen Krankenhaus, Dept Neurol, Hamburg, Germany; Univ Med Ctr Gottingen, Elbe Klinken Stade, Dept Neurol, Gottingen, Germany; Univ Hosp Carl Gustav Carus, Dept Neurol, Dresden, Germany; Heidelberg Univ, Med Fac Mannheim, Dept Neurol, Mannheim, Germany; Univ Hamburg Eppendorf, Kopf & Neurozentrum, Neurol Klin & Poliklin, Hamburg, Germany; Univ Thessaly, Sch Hlth Sci, Dept Internal Med, Larisa, Greece; Metropolitan Hosp, Stroke Unit, Dept Neurol 2, Piraeus, Greece; Univ Szeged, Szeged, Hungary; Univ Pecs, Pecs, Hungary; IRCCS, Stroke Ctr, Verona, Italy; Osped San Paolo, Dept Neurol, Savona, Italy; Fdn Policlin Univ Agostino Gemelli, Inst Neurol, Rome, Italy; Careggi Univ Hosp, Intervent Neurovasc Unit, Florence, Italy; Azienda Socio Sanit Terr ASST Lecco, Stroke Unit, Lecce, Italy; Maastricht Univ, Med Ctr, Maastricht, Netherlands; Univ Med Ctr Groningen, Dept Neurol, Radiol, Groningen, Netherlands; Haaglanden Med Ctr, Dept Neurol, The Hague, Netherlands; Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway; Univ Oslo, HELSAM, Gen Practice, Oslo, Norway; Specialist Hosp Konskie, Neurol Ward, Stroke Unit, Gimnazjalna, Poland; Jan Kochanowski Univ Humanities & Sci, Coll Med, Kielce, Poland; Dist Hosp Skarzysko Kamienna, Stroke Unit, Neurol Ward, Skarzysko Kamienna, Poland; Szpitala T Marciniaka Wroclaw, Dept Neurol, Wroclaw, Poland; Inst Psychiat & Neurol, Dept Neurol 2, Warsaw, Poland; Poznan Univ Med Sci, Dept Neurol & Cerebrovasc Disorders, Poznan, Poland; 107 Mil Hosp Polyclin, Walcz, Poland; St Queen Jadwiga Clin Reg Hosp 2, Dept Neurol, Rzeszow, Poland; Med Univ Lublin, Dept Neurol, Lublin, Poland; Inst Psychiat & Neurol, Dept Neurol 1, Warsaw, Poland; Jan Kochanowski Univ Humanities & Sci, Coll Med, Holy Spirit Specialist Hosp Sandomierz, Dept Neurol, Kielce, Poland; Jan Kochanowski Univ Humanities & Sci, Coll Med, Holy Spirit Specialist Hosp Sandomierz, Stroke Unit, Kielce, Poland; Hosp M Kopernik, Neurol & Stroke Dept, Copernicus PL, Gdansk, Poland; Stanislaw Staszic Univ Appl Sci, Dept Neurol, Stroke Unit, Pila, Poland; Ctr Hosp Univ Lisboa Cent, Hosp Sao Jose, Lisbon, Portugal; Hosp Pedro Hispano, Stroke Unit, Matosinhos, Portugal; Ctr Hosp Univ Sao Joao, Dept Internal Med, Dept Neuroradiol, Stroke Unit, Porto, Portugal; Ctr Hosp Lisboa Ocidental, Hosp Egas Moniz, Dept Neurol, Lisbon, Portugal; North Lisbon Univ Hosp, Hosp Santa Maria CHLN, Dept Neurosci, Lisbon, Portugal; Ctr Hosp Univ Lisboa Cent, Hosp Sao Jose, Lisbon, Portugal; Hosp Garcia de Orta, Dept Neurol, Almada, Portugal; Transilvania Univ, Dept Neurol, Brasov, Romania; Fac Hosp Trnava, Dept Neurol, Trnava, Slovakia; Hosp Univ La Paz, Dept Neurol, Madrid, Spain; Hosp Univ La Paz, Stroke Ctr, Madrid, Spain; Univ Valladolid, Hosp Clin Univ, Dept Neurol, Valladolid, Spain; Complejo Hosp Univ Albacete, Dept Neurol, Albacete, Spain; Hosp Univ Ramon & Cajal, Unidad Ictus, Dept Neurol, Madrid, Spain; Hosp Univ Virgen Macarena, Dept Neurol, Seville, Spain; Inst Biomed Sevilla IbiS, Neurovasc Res Lab, Seville, Spain; Univ Valladolid, Rio Hortega Univ Hosp, Valladolid, Spain; Hosp Clin Barcelona, Cerebrovasc Dis, Barcelona, Spain; Karolinska Univ Hosp, Dept Neurol, Stockholm, Sweden; Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden; Univ Hosp Geneva, Dept Intervent Neuroradiol, Geneva, Switzerland; Univ Hosp Basel, Dept Intervent & Diagnost Neuroradiol, Radiol & Nucl Med, Basel, Switzerland; Univ Bern, Dept Neurol, Bern, Switzerland; Univ Bern, Dept Neuroradiol, Bern, Switzerland; Lausanne Univ Hosp, Dept Neurosci, Lausanne, Switzerland; Imperial Coll Healthcare NHS Trust, Charing Cross Hosp, Dept Stroke Med, London, England; Nottingham Univ Hosp NHS Trust, Queens Med Ctr, Dept Neurol, Nottingham, England; Univ Alberta, Dept Neurol, Edmonton, AB, Canada; McMaster Univ, Dept Neurol, Hamilton, ON, Canada; Univ Calgary, Dept Clin Neurosci, Calgary, AB, Canada; Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada; Univ British Columbia, Dept Neurol, Vancouver, BC, Canada; Mackenzie Hlth, Richmond Hill, ON, Canada; Univ Toronto, Sunnybrook Hlth Sci Ctr, Dept Neurol, Toronto, ON, Canada; CHU Laval, Hop Enfant Jesus, Dept Neurol, Quebec City, PQ, Canada; Univ Toronto, Dept Neurol, Toronto, ON, Canada; Univ Toronto, St Michaels Hosp, Med, Toronto, ON, Canada; Hosp Dr Rafael A Calderon Guardia, CCSS, Dept Neurosci, San Jose, Costa Rica; Hosp Gen San Juan de Dios, Neurovasc Serv, Guatemala City, Guatemala; Inst Guatemalteco Seguridad Social, Hosp Gen Enfermedades, Dept Neurol, Guatemala City, Guatemala; Univ Autonoma Nuevo Leon, Univ Hosp Jose Eleuterio Gonzalez, Dept Neurol, San Nicolas De Los Garza, Nuevo Leon, Mexico; Pacifica Salud Hosp Punta Pacifica, Panama City, Panama; Univ Kansas, Med Ctr, Dept Neurol, Radiol, Lawrence, KS 66045 USA; Valley Baptist Hosp, Dept Neurointervent Neurosurg, Ridgewood, NJ USA; Palmetto Gen Hosp, Tenet, FL USA; Rutgers, New Jersey Med Sch, Univ Hosp Newark, Neurol, Newark, NJ USA; Community Healthcare Syst, Munster, IN USA; Calif Pacific Med Ctr, Dept Neurol, San Francisco, CA USA; Mt Sinai South Nassau, Dept Neurol, New York, NY USA; Univ Toledo, 2801 W Bancroft St, Toledo, OH 43606 USA; Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA; Inova Fairfax Hosp, Neurosci, Falls Church, VA USA; Abington Jefferson Hosp, Dept Neurol, Abington, PA USA; Mt Sinai South Nassau, Dept Neurol, New York, NY USA; Baptist Hlth Med Ctr, Little Rock, AR USA; HCA Houston Healthcare Clearlake, Dept Neurol, Webster, TX USA; Erlanger, Dept Neurol, Chattanooga, TN USA; St Louis Univ, Dept Vasc & Neurointervent Serv, St Louis, MO 63103 USA; Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA; Univ Iowa Hosp & Clin, Dept Neurol Neurosurg & Radiol, Iowa City, IA 52242 USA; Swedish Med Ctr, Dept Radiol, Englewood, CO 80110 USA; Univ Maryland, Sch Med, Dept Radiol, Neurosurg, Baltimore, MD 21201 USA; Adventist Hlth Glendale Comprehens Stroke Ctr, Los Angeles, CA USA; Wellstar Neurosci Inst, Marietta, GA USA; Univ Texas Rio Grande Valley, Valley Baptist Med Ctr, Dept Neurol, Edinburg, TX USA; Beth Israel Lahey Hlth, Lahey Hosp & Med Ctr, Dept Neurol, Burlington, MA USA; Wayne State, Dept Neurol, Detroit, MI USA; Southern Illinois Univ, Sch Med, HSHS St Johns Hosp, Springfield, IL USA; Virginia Hosp Ctr, Arlington, VA USA; Univ Michigan, Dept Neurol, Ann Arbor, MI USA; New York Presbyterian Queens, Weill Cornell Med Coll, Flushing, NY USA; Ohio State Univ, Dept Neurol, Columbus, OH 43210 USA; Tufts Med Ctr, Dept Neurol, Boston, MA 02111 USA; St Louis Univ, Vasc & Neurointervent Serv, St Louis, MO 63103 USA; Miami Cardiac & Vasc Inst, Miami Beach, FL USA; Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA; Steward Holy Family Hosp, Dept Emergency Med, Methuen, MA USA; Vidant Med Ctr, Greenville, NC USA; Univ Miami, Miller Sch Med, Dept Neurol, Miami, FL 33136 USA; Univ Miami, Miller Sch Med, Neurosurg, Miami, FL 33136 USA; SUNY Upstate New York, Dept Neurol, Syracuse, NY USA; Mem Neurosci Inst, Pembroke Pines, FL USA; Michigan State Univ, Coll Med, Spectrum Hlth, Neurosci, Grand Rapids, MI USA; Sutter Hlth, Sacramento, CA USA; Maine Med Ctr, Dept Neurol, Portland, ME 04102 USA; Bayhealth, Dept Neurol, Dover, DE USA; Emory Univ, Dept Neurol & Pediat, Atlanta, GA 30322 USA; Univ Arkansas Med Sci, Dept Neurol, Little Rock, AR 72205 USA; UT Southwestern Med Ctr, Dept Radiol & Neurol, Dallas, TX USA; Ascens St John Med Ctr, Tulsa, OK USA; Riverside Reg Med Ctr, Newport, VA USA; Boston Univ, Sch Med, Dept Neurol, Boston, MA 02215 USA; Hosp Univ Penn, Dept Neurol, 3400 Spruce St, Philadelphia, PA 19104 USA; Univ Washington, Sch Med, Dept Neurol, Seattle, WA USA; Univ Massachusetts, Med Ctr, Dept Neurol, Worcester, MA 01655 USA; Creighton Univ, CHI Immanuel Neurol Inst, Dept Neurol, Omaha, NE 68178 USA; Holy Cross Hosp, Ft Lauderdale, FL USA; Univ Calif Los Angeles, Dept Neurol, Intervent Neuroradiol, Los Angeles, CA 90024 USA; Banner Desert Med Ctr, Mesa, AZ USA; Hosp Agudos Dr Ignacio Privano, Buenos Aires, DF, Argentina; FLENI, Neurol Res Inst, Buenos Aires, DF, Argentina; Univ Sao Paulo, Hosp Clin, Sao Paulo, Brazil; Sumare State Hosp, Sao Paulo, Brazil; Hosp Vera Cruz, Deus Campinas, Brazil; Irmanandade Santa Casa Porto Alegre, Porto Alegre, RS, Brazil; Hosp Geral Fortaleza, Stroke Unit, Fortaleza, Ceara, Brazil; Hosp Sao Jose, Stroke Unit, Joinville, SC, Brazil; Nossa Senhora de Conceicao Hosp, Stroke Unit, Neurol, Porto Alegre, RS, Brazil; Hosp Moinhos de Vento, Dept Neurol, Porto Alegre, RS, Brazil; Hosp Base Dist Fed, Dept Neurol, Brasilia, DF, Brazil; Univ Fed Parana, Hosp Juliane, Hosp Ana, Curitiba, Parana, Brazil; Univ Desarrollo, Clin Alemana, Dept Neurol & Psychiat, Neurol Serv,Vasc Neurol Unit, Santiago, Chile; Hosp Padre Hurtado, Santiago, Chile; Fdn Valle Lili, Cali, Colombia; Fdn Santa Fe Bogota, Stroke Ctr, Bogota, Colombia; Hosp Dept Univ Quindio San Juan de Dios, Dept Neurol, Armenia, Colombia; Clin Univ Colombia, Bogota, Colombia; Univ Hosp San Vicente Fdn, Medellin, Colombia; Hosp Infantil Univ San Jose, Bogota, Colombia; Univ Nacl Asuncion, Fac Ciencias Med, Hosp Clin, Asuncion, Paraguay; Inst Previs Social, Hosp Cent, Neurol Serv, Asuncion, Paraguay; Hosp Cent Policia Rigoberto Caballero, Internal Med Serv, Asuncion, Paraguay; Natl Inst Neurol Sci Lima, Lima, Peru; Hosp Edgardo Rebagliati Martins, Lima, Peru; Royal Melbourne Hosp, Dept Neurol, Parkville, Vic, Australia; Univ Western Australia, Sir Charles Gairdner Hosp, Perth, WA, Australia; Univ Western Australia, Sch Med, Fac Hlth & Med Sci, Perth, WA, Australia; Univ Melbourne, Ballarat Hlth Serv, Melbourne, Vic, Australia; Royal Adelaide Hosp, Dept Neurol, Adelaide, SA, Australia; Royal North Shore Hosp, Dept Neurosurg, Sydney, NSW, Australia; Mater Hosp, Dept Neurol, Brisbane, Qld, Australia; Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia; Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia; Greymouth Base Hosp, Greymouth, New Zealand; Christchurch Hosp, Dept Neurol, Christchurch, New Zealand; Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA; Mercy Hlth Neurosci, Dept Neurol, Toledo, OH USA | ; Nogueira, Raul/LSI-7118-2024; Farhudi, Mehdi/L-6403-2017; Bernava, Gianmarco/ABE-9898-2020; Sathya, Anvitha/HDN-1153-2022; Kamenova, Saltanat/ABD-9372-2021; Budincevic, Hrvoje/AAU-4886-2020; Thomalla, Götz/HPB-8558-2023; Jura, René/AAC-7322-2021; Seo, Jung/N-2344-2017; SIENKIEWICZ-JAROSZ, HALINA/JKH-8741-2023; Vanhooren, Geert/H-4433-2011; Bandini, Fabio/AAE-3431-2020; Park, Hyungjong/AAI-5361-2020; Wahab, Kolawole Wasiu/F-1206-2010; Gomes Ferreira, Paulo Venâncio/GPK-2742-2022; Martins, Sheila/L-1616-2016; Sedghi, Annahita/AAU-2249-2021; Chen, Chih-Hao/AAA-7297-2022; Nunes, Ana/A-5086-2012; Yamada, Satohi/HHY-9909-2022; Hokmabadi, Elyar/L-8926-2017; Yperzeele, Laetitia/AAQ-7742-2020; Field, Thalia/G-8477-2019; Truelsen, Thomas/AAY-1549-2020; Bayona, Hernan/I-3060-2019; Kleinig, Timothy/AFP-4371-2022; Farooqui, Mudassir/K-8382-2019; Cordonnier, Charlotte/O-3258-2017; Monteiro, Rodrigo/HLQ-7233-2023; BAYONA, HERNAN/I-3060-2019; Shang, Xianjin/KUD-9843-2024; Malhotra, Konark/N-5883-2016; Pandian, Jeyaraj/AAV-5591-2020; Rahangdale, Rahul/AAA-7183-2022; Palaiodimou, Lina/AFT-5092-2022; Ozretic, David/MVU-8038-2025; Arenillas, Juan/AAE-1142-2020; Liebeskind, David/B-1991-2008; Min, Jiangyong/JEF-7306-2023; Leahu, Pavel/ABE-8752-2021; Riahi, Anis/J-4956-2019; Fischer, Urs/HJH-5619-2023; Starosciak, Amy/AAD-4892-2021; Kargiotis, Odysseas/MHR-2954-2025; Hill, Michael/C-9073-2012; Raz, Eytan/I-5738-2012; Groppa, Stanislav/AAM-5905-2020; Toomsoo, Toomas/KFS-0993-2024; Frisullo, Giovanni/ABC-7406-2021; cernik, David/AAG-9836-2021; van den Wijngaard, Ido/N-2331-2019; Ntaios, George/AAG-1908-2019; Sahathevan, Ramesh/S-9302-2019; Vachova, Marta/IAR-6804-2023; Pinho e Melo, Teresa/N-3325-2015; Arribas, Miguel/D-6936-2016; Martins, Rodrigo/C-4337-2013; ROTHSTEIN, AARON/X-4338-2019; Saposnik, Gustavo/M-3937-2017; Sadeghi Hokmabadi, Elyar/L-8926-2017; Chen, Li-Tzong/D-2071-2010; Campbell, Bruce/J-1220-2019; Sui, Yi/I-5278-2019; Co, co/KIE-7449-2024; Khosravani, Houman/JDX-0634-2023; Demchuk, Andrew/E-1103-2012; Korv, Janika/I-4395-2015; Watanabe, Daisuke/AAG-2962-2021; Falup-Pecurariu, Cristian/AAP-9286-2020; Mohammaden, Mahmoud/JOK-3317-2023; Hassan, Farouk/AAO-6296-2021; Leung, Thomas/AAU-6475-2021; Lemmens, Robin/KDO-9601-2024; Adebayo, Philip/ABE-1191-2020; Zhao, Wenlong/IQS-8798-2023; Arabambi, Babawale/GSM-7498-2022; Nalleballe, Krishna/ABA-8434-2020; Kristoffersen, Espen Saxhaug/ABD-4606-2021; Siepmann, Timo/AAJ-1344-2021; Butt, Asif/AAO-8307-2020; Schmidt, Holger/ABU-8972-2022; Vachová, Marta/IAR-6804-2023; Aguiar de Sousa, Diana/J-4105-2013; Hankey, Graeme/H-4968-2014; Barboza, Miguel/AAU-2368-2020; Nakahara, Ichiro/G-3259-2010; Tola Arribas, Miguel Angel/D-6936-2016; Kõrv, Janika/I-4395-2015; Vibo, Riina/H-3874-2018; Rahman, Aminur/JSL-0118-2023; Conforto, Adriana/C-9371-2014; Prochazka, Petr/AHC-0289-2022; zetola, viviane/KSP-5773-2024; Akhtar, Naveed/HPF-0482-2023; Mikulik, Robert/M-1757-2016; Ahdab, Rechdi/AAG-4534-2020; Klivenyi, Peter/LOR-7860-2024; Qian, Zhong/E-8884-2016; Yaghi, Shadi/Q-8258-2019; Pop, Raoul/S-9431-2019; Brola, Waldemar/D-8813-2014; Montaner, Joan/D-3063-2015; Wahab, K./F-1206-2010; Volny, Ondrej/AAR-7620-2020; Male, Shailesh/D-3038-2019; Wiszniewska, Malgorzata/KMA-3155-2024; Cruz, Vítor/AAM-3014-2020; de Sousa, Diana/J-4105-2013; Venketasubramanian, Narayanaswamy/GPP-5948-2022; Perez-Sanchez, Soledad/AFN-4852-2022; Alhazzani, Adel/AAK-1166-2021; Lima, Fabricio/E-6507-2015; Ayo-Martin, Oscar/Q-8541-2017; shoamanesh, ashkan/AHE-1772-2022; AYKAC, OZLEM/D-7439-2018; Badruddin, B./D-4773-2015; Vanhooren, Geert/JCE-4722-2023; Alonso de Leciñana, María/C-1464-2017; Lavados, Pablo/E-9918-2016; Leyva Romero, José Roberto/KCL-5439-2024; Li, Guangwen/AAD-5859-2020; McDermott, Mollie/AAZ-2358-2021; renieri, leonardo/AAC-3202-2019; Mansour, Ossama/F-4592-2010; Aref, Hany/AAW-3366-2020; Zhanuzakov, Murat/S-3899-2017; Novák, Jan/AAS-8751-2021; Kočí, Lubomír/AAD-2870-2019; Tarkanyi, Gabor/AGX-9879-2022; Adami, Alessandro/P-1831-2018; Amaya, Pablo/AAX-4258-2020; Tsivgoulis, Georgios/AAD-7467-2019; Monteiro, Rodrigo/JFB-4965-2023; ma, alice/GMW-6710-2022; PN, Sylaja/ABE-3114-2020; Psychogios, Marios/AFO-4629-2022; Thijs, Vincent/C-3647-2009; Roushdy, Tamer/ABG-9151-2020; Nguyen, Thanh/ABH-4370-2020; mansour, ossama/F-4592-2010; Iversen, Helle/P-5726-2019; Malik, Amer/MTB-3558-2025; Wan Zaidi, Wan Asyraf/HKM-7276-2023; Nagel, Simon/AAB-9266-2022; Tedim Cruz, Vitor/AAM-3014-2020; Sramek, Martin/O-2603-2017; Horev, Anat/AAB-4919-2021 | 7102312928; 8548530400; 55881763400; 36084814200; 57205587120; 56157900900; 57220957071; 57218706309; 7102938849; 6701335522; 55781226000; 54781237100; 55882681500; 24069592700; 50562171400; 6602337786; 7102618782; 56927323900; 40661717000; 56320919700; 14420928200; 37115499700; 8044142400; 16426036800; 55791830600; 12773488600; 56646480300; 26768039500; 57189261947; 57452600600; 7403890783; 35110011900; 25625697600; 13403148800; 57211113680; 34568584900; 57224597537; 55006485900; 36131205700; 57207786213; 57224598106; 57190428377; 57205423058; 57199153699; 25951730100; 57224598687; 57209643194; 56641874300; 25643405600; 24367621900; 57003660700; 57225353610; 26643746200; 55821853700; 25958929500; 56092484600; 57201479020; 57224599835; 57977795800; 56487205200; 57223388409; 57197757783; 57145820800; 57211059860; 55702518857; 57225013088; 57217232562; 57216861368; 57075761700; 34877636400; 57224597701; 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56218838000; 7201920105; 36156507300; 57208308641; 57222612641; 23467107900; 57191972823; 55567073700; 57224596884; 15825552300; 57203874100; 35574701900; 57203272830; 35269850500; 57200395835; 56040583200; 56091847600; 59275701700; 7101619776; 57224598653; 57224597565; 23570191800; 57217685069; 6603204615; 57204776921; 56754540500; 6603154545; 57224598991; 6506097171; 6701824484; 57224596922; 57193111655; 6603033794; 6507110786; 57224601139; 57224596347; 7102541736; 57188813149; 57224596986; 8704609400; 57209248893; 57224601199; 8449947400; 13406691400; 57188955599; 57212555045; 57204794060; 57224598404; 57214936366; 57193423370; 57224600979; 25923121700; 57224600898; 57203091820; 57224597909; 57205703446; 57554267300; 57224600102; 57224599320; 57191824728; 57209256204; 55337345500; 7102816661; 57210996544; 6506309674; 57216830107; 57205303621; 35332739200; 6701393042; 57222310190; 57224598974; 6506368654; 7004045734; 6507566063; 7102837475; 6701330053; 59709574500 | thanh.nguyen@bmc.org; | NEUROLOGY | NEUROLOGY | 0028-3878 | 1526-632X | 96 | 23 | SCIE | CLINICAL NEUROLOGY | 2021 | 12.258 | 4.0 | 9.09 | 2025-07-30 | 108 | 105 | COVID-19; Cross-Sectional Studies; Hospitalization; Humans; Pandemics; Retrospective Studies; SARS-CoV-2; Stroke; Thrombolytic Therapy; cerebrovascular accident; cross-sectional study; fibrinolytic therapy; hospitalization; human; pandemic; retrospective study | English | 2021 | 2021-06-08 | 10.1212/wnl.0000000000011885 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Numerical investigation of the electro-thermo-convection of dielectric liquid in a square cavity with vertical walls composed of alternately arranged electrodes | Research on the improvement of the heat transfer performance by forming a voltage difference in the dielectric fluid has been actively conducted in the recent years. This study investigates the electro-thermo-convective flow in a two-dimensional (2D) square cavity composed of cold right and hot left walls. We introduce herein the results of the heat transfer enhancement when positive and grounded electrodes are alternately arranged on each vertical wall instead of installing the same kind of electrode (positive or grounded electrode) on the entire surface of a vertical wall. The case of alternately arranged electrodes demonstrates that the heat transfer coefficient increases more than twice compared to that of the single kind of electrode. The heat transfer enhancement by the electric field is maximized in the low Rayleigh condition. In the Ra = 2000 and T = 1000 condition, the alternately placed electrodes accomplished a 10 times higher heat transfer coefficient when compared to the pure natural convection. The heat transfer results of using a silicon oil have been summarized for the Rayleigh number range of 2000 to 106 and electrical Rayleigh number of 0 to 1000. | Son, Jong Hyeon; Park, Il Seouk | Kyungpook Natl Univ, Sch Mech Engn, 80 Daehakro, Daegu 41566, South Korea | 55156951300; 50262800000 | einstein@knu.ac.kr; | INTERNATIONAL COMMUNICATIONS IN HEAT AND MASS TRANSFER | INT COMMUN HEAT MASS | 0735-1933 | 1879-0178 | 129 | SCIE | MECHANICS;THERMODYNAMICS | 2021 | 6.782 | 4.0 | 0.16 | 2025-07-30 | 6 | 6 | Alternately arranged electrode; Electro-thermo-convective flow; Heat transfer enhancement; Dielectric fluid; Nusselt number | HEAT-TRANSFER ENHANCEMENT; UNIPOLAR INJECTION; NATURAL-CONVECTION; FLOW; CHARGE; LAYER; SIMULATION; CONDUCTION; ENCLOSURE | Alternately arranged electrode; Dielectric fluid; Electro-thermo-convective flow; Heat transfer enhancement; Nusselt number | Dielectric liquids; Electric fields; Electrodes; Heat convection; Alternately arranged electrode; Condition; Dielectric fluid; Electro-thermo-convective flow; Grounded electrodes; Heat transfer co-efficients; Heat Transfer enhancement; Positive electrodes; Square cavity; Vertical wall; Heat transfer coefficients | English | 2021 | 2021-12 | 10.1016/j.icheatmasstransfer.2021.105655 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease | Tryptophan hydroxylase 1 (TPH1) has been recently suggested as a promising therapeutic target for treating obesity and fatty liver disease. A new series of 1,2,4-oxadiazolylphenyl alanine derivatives were identified as TPH1 inhibitors. Among them, compound 23a was the most active in vitro, with an IC50 (half-maximal inhibitory concentration) value of 42 nM, showed good liver microsomal stability, and showed no significant inhibition of CYP and hERG. Compound 23a inhibited TPH1 in the peripheral tissue with limited BBB penetration. In high-fat diet-fed mice, 23a reduced body weight gain, body fat, and hepatic lipid accumulation. Also, 23a improved glucose intolerance and energy expenditure. Taken together, compound 23a shows promise as a therapeutic agent for the treatment of obesity and fatty liver diseases. | Bae, Eun Jung; Choi, Won Gun; Pagire, Haushabhau S.; Pagire, Suvarna H.; Parameswaran, Saravanan; Choi, Jun-Ho; Yoon, Jihyeon; Choi, Won-il; Lee, Ji Hun; Song, Jin Sook; Bae, Myung Ae; Kim, Mijin; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee | Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; Korea Adv Inst Sci & Technol, Grad Sch Med Sci & Engn, Daejeon 34141, South Korea; Korea Res Inst Chem Technol, Bio & Drug Discovery Div, Daejeon 34114, South Korea; Kyungpook Natl Univ, Res Inst Aging & Metab, Daegu 41404, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea | Parameswaran, Saravanan/F-3189-2011; P, Saravanan/F-3189-2011; Ahn, Jin/C-6122-2019; CHOI, WON/J-1665-2012; Lee, In-Kyu/AAR-6374-2021; Kim, Hail/C-5608-2018 | 57200112023; 57216542768; 55599893000; 56716279400; 29167545800; 56395639200; 57216544129; 57191264924; 57221787048; 57211755720; 7005711682; 56984392800; 36910340400; 36071537600; 7410126420; 56714432600 | hailkim@kaist.edu;jhahn@gist.ac.kr; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 64 | 2 | SCIE | CHEMISTRY, MEDICINAL | 2021 | 8.039 | 4.0 | 0.33 | 2025-07-30 | 6 | 5 | SEROTONIN SYNTHESIS; PARA-CHLOROPHENYLALANINE; P-CHLOROPHENYLALANINE; DISCOVERY; TARGET | Adiposity; Alanine; Animals; Anti-Obesity Agents; Diet, High-Fat; Energy Metabolism; Enzyme Inhibitors; Fatty Liver; Glucose Intolerance; Humans; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Microsomes, Liver; Models, Molecular; Tryptophan Hydroxylase; Weight Gain; 1,2,4 oxadiazole derivative; 1,2,4 oxadiazolylphenyl alanine derivative; 2 amino 3 [4 [5 [4' hydroxy 6 methoxy(1,1' biphenyl) 3 yl] 1,2,4 oxadiazol 3 yl]phenyl]propanoic acid; antiobesity agent; buspirone; cholesterol; cytochrome P450; fenclonine; liver protective agent; lp 533401; messenger RNA; oxygenase inhibitor; phenylalanine derivative; potassium channel HERG; serotonin; serotonin antagonist; telotristat; triacylglycerol; tryptophan hydroxylase; tryptophan hydroxylase 1; unclassified drug; uncoupling protein 1; alanine; antiobesity agent; enzyme inhibitor; TPH1 protein, human; tryptophan hydroxylase; animal cell; animal experiment; animal model; animal tissue; antiobesity activity; Article; blood brain barrier; body weight gain; controlled study; diet-induced obesity; drug blood level; drug brain level; drug design; drug dose comparison; drug efficacy; drug mechanism; drug penetration; drug synthesis; drug targeting; energy expenditure; enzyme activity; enzyme inhibition; fatty liver; glucose intolerance; high-fat diet-induced fatty liver; human; human cell; IC50; in vitro study; lipid liver level; lipid storage; liver microsome metabolism; liver protection; male; metabolic stability; molecular docking; mouse; mRNA expression level; nonhuman; obesity; plasma concentration-time curve; rat; serotonin blood level; serotonin brain level; animal; C57BL mouse; drug effect; energy metabolism; fatty liver; glucose intolerance; lipid diet; lipid metabolism; liver; liver microsome; metabolism; molecular model; obesity; synthesis | English | 2021 | 2021-01-28 | 10.1021/acs.jmedchem.0c01560 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor | Triple-negative breast cancer (TNBC) is an aggressive breast-cancer subtype associated with poor prognosis and high relapse rates. Monopolar spindle 1 kinase (MPS1) is an apical dual-specificity protein kinase that is over-expressed in TNBC. We herein report a highly selective MPS1 inhibitor based on a 7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile scaffold. Our lead optimization was guided by key X-ray crystal structure analysis. In vivo evaluation of candidate (9) is shown to effectively mitigate human TNBC cell proliferation. | Lee, Younho; Kim, Hyunkyung; Kim, Haelee; Cho, Ha Yeon; Jee, Jun-Goo; Seo, Kyung-Ah; Son, Jung Beom; Ko, Eunhwa; Choi, Hwan Geun; Kim, Nam Doo; Kim, Ikyon | Yonsei Univ, Coll Pharm, Incheon 21983, South Korea; Yonsei Univ, Yonsei Inst Pharmaceut Sci, Incheon 21983, South Korea; Voronoibio, Incheon 21984, South Korea; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Res, Daegu 41566, South Korea; B2Sbio, Incheon 21984, South Korea | 57207015808; 57223923410; 57203102011; 57223928388; 7004327823; 57223929941; 57194241237; 56682574900; 36140936200; 57212056577; 20433320500 | namdoo@voronoibio.com;ikyonkim@yonsei.ac.kr; | JOURNAL OF MEDICINAL CHEMISTRY | J MED CHEM | 0022-2623 | 1520-4804 | 64 | 10 | SCIE | CHEMISTRY, MEDICINAL | 2021 | 8.039 | 4.0 | 0.83 | 2025-07-30 | 11 | 10 | SMALL-MOLECULE INHIBITOR; KINASE INHIBITOR; MPS1; DISCOVERY | Administration, Oral; Animals; Binding Sites; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Female; Half-Life; Humans; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases; Pyrimidines; Pyrroles; Structure-Activity Relationship; Transplantation, Heterologous; cell cycle protein; protein kinase inhibitor; protein serine threonine kinase; protein tyrosine kinase; pyrimidine derivative; pyrrole derivative; Pyrrolo(2,3-d)pyrimidine; TTK protein, human; animal; binding site; breast tumor; chemistry; drug design; female; half life time; human; Institute for Cancer Research mouse; metabolism; molecular docking; mouse; oral drug administration; pathology; structure activity relation; tumor cell line; X ray crystallography; xenograft | English | 2021 | 2021-05-27 | 10.1021/acs.jmedchem.1c00542 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Design of PD-1-decorated nanocages targeting tumor-draining lymph node for promoting T cell activation | Targeted delivery of immunomodulatory molecules to the lymph nodes is an attractive means of improving the efficacy of anti-cancer immunotherapy. In this study, to improve the efficacy of PD-1 blockade-based therapy, nanocages were designed by surface engineering to decorate a programmed cell death protein 1 (PD-1) that is capable of binding against programmed death-ligand 1 (PD-L1) and -ligand 2 (PD-L2). This nanocage-mediated multivalent interaction remarkably increases the binding affinity and improves the antagonistic activity compared to free soluble PD-1. In addition, with the desirable nanocage size for optimal tumor-draining lymph node (TDLN) targeting (approximately 20 nm), rapid draining and increased accumulation into the TDLNs were observed. Moreover, the interference of the PD-1/PD-L axis with ultra-high affinity in the tumor microenvironment (effector phase) and the TDLNs (cognitive phase) significantly enhances the dendritic cell-mediated tumor-specific T cell activation. This characteristic successfully inhibited tumor growth and induced complete tumor eradication in some mice. Thus, the delivery of immunomodulatory molecules with nanocages can be a highly efficient strategy to achieve stronger anti-tumor immunity. | Kim, Gi Beom; Sung, Hyo-Dong; Nam, Gi-Hoon; Kim, Wonjun; Kim, Seohyun; Kang, Dayeon; Lee, Eun Jung; Kim, In-San | Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Daegu 41566, South Korea; Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02215 USA | ; Nam, Gi-Hoon/I-6664-2018; Lee, Seung Eun/ABG-1607-2021 | 57197865834; 57222632058; 57192919427; 57221789815; 57212447863; 57222640929; 57239965200; 34770432800 | eunjunglee@knu.ac.kr;iskim14@kist.re.kr; | JOURNAL OF CONTROLLED RELEASE | J CONTROL RELEASE | 0168-3659 | 1873-4995 | 333 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2021 | 11.467 | 4.1 | 1.29 | 2025-07-30 | 19 | 19 | Nanocage; Surface engineering; PD-1; PD-L blockade; Tumor-draining lymph node; Drug delivery | H-FERRITIN; EXPRESSION; NIVOLUMAB; PD-L1 | Drug delivery; Nanocage; PD-1/PD-L blockade; Surface engineering; Tumor-draining lymph node | Animals; Immunotherapy; Lymph Nodes; Mice; Neoplasms; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment; Binding energy; Cell death; Cell engineering; Chemical activation; Controlled drug delivery; Ligands; Mammals; Molecules; T-cells; Targeted drug delivery; CD3 antigen; CD40 antigen; CD8 antigen; CD86 antigen; complementary DNA; gamma interferon; immune checkpoint inhibitor; Ki 67 antigen; nanocage; programmed death 1 receptor; receptor type tyrosine protein phosphatase C; transferrin receptor; programmed death 1 receptor; Cancer immunotherapy; Immunomodulatory; Lymph node; Nanocages; PD-1/PD-L blockade; Programmed cell deaths; Surface engineering; T cell activation; Targeted delivery; Tumor-draining lymph node; animal experiment; animal model; animal tissue; antagonistic effect; Article; binding affinity; biodegradability; bioluminescence; cancer inhibition; cancer tissue; carcinogenesis; chemical structure; controlled study; CT26.CL25 cell line; dendritic cell; dissociation constant; drug delivery system; drug efficacy; flow cytometry; fluorescence intensity; immunocompetent cell; immunofluorescence; in vitro study; in vivo study; limit of quantitation; molecular cloning; mouse; neoplasm; nonhuman; photon correlation spectroscopy; polyacrylamide gel electrophoresis; polymerase chain reaction; priority journal; protein expression; surface plasmon resonance; T lymphocyte activation; transmission electron microscopy; tumor draining lymph node; tumor microenvironment; tumor volume; upregulation; animal; immunotherapy; lymph node; neoplasm; T lymphocyte; Tumors | English | 2021 | 2021-05-10 | 10.1016/j.jconrel.2021.03.038 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Fast Multi-Type Tree Partitioning for Versatile Video Coding Using a Lightweight Neural Network | In this paper, we propose a fast decision scheme using a lightweight neural network (LNN) to avoid redundant block partitioning in versatile video coding (VVC). A more versatile block structure, named the multi-type tree (MTT) structure, which includes binary trees (BTs) and ternary trees (TTs), is adopted by VCC, in addition to the traditional quadtree structure. The MTT improved the coding efficiency compared with previous video coding standards. However, the new tree structures, mainly TT, significantly increased the complexity of the VVC encoder. Although widespread application of VVC has been inhibited, this problem has not yet been investigated thoroughly in the literature. In this study, we first determine the statistical characteristics of coded parameters that exhibit correlation with the TT and develop two useful types of features-explicit VVC features (EVFs) and derived VVC features (DVFs)-to facilitate the intra coding of VVC. These features can be obtained efficiently during the intra prediction before the determination of the best block partitioning during rate-distortion optimization in VVC encoding. Our LNN model decides whether to terminate the nested TT block structures subsequent to a quadtree based on the features. The experimental results confirm that the proposed method substantially decreases the encoding complexity of VVC with a slight coding loss under the All Intra configuration. Our code, models, and dataset are available at https://github.com/foriamweak/MTTPartitioningLNN. | Park, Sang-hyo; Kang, Je-Won | Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea; Ewha Womans Univ, Dept Elect & Elect Engn, Seoul, South Korea; Ewha Womans Univ, Smart Factory Multidisciplinary Program, Seoul, South Korea | ; Kang, Jewon/AAU-9722-2020; Park, Sang-hyo/W-9343-2019 | 55362514700; 56367466400 | s.park@knu.ac.kr;jewonk@ewha.ac.kr; | IEEE TRANSACTIONS ON MULTIMEDIA | IEEE T MULTIMEDIA | 1520-9210 | 1941-0077 | 23 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;COMPUTER SCIENCE, SOFTWARE ENGINEERING;TELECOMMUNICATIONS | 2021 | 8.182 | 4.1 | 3.22 | 2025-07-30 | 53 | 54 | Encoding; Complexity theory; Image coding; Transforms; Tools; Standards; Quantization (signal); Block partitioning; Deep learning; Encoding complexity; Image compression; Intra prediction; Multi-type tree; Neural network; Video compression; VVC | CU SIZE DECISION; DEPTH DECISION; MODE; SELECTION | Block partitioning; Deep learning; Encoding complexity; Image compression; Intra prediction; Multi-type tree; Neural network; Video compression; VVC | Binary trees; Complex networks; Electric distortion; Encoding (symbols); Image coding; Network coding; Neural networks; Signal distortion; Trees (mathematics); Block partitioning; Coding efficiency; Encoding complexity; Quadtree structure; Rate-distortion optimization; Statistical characteristics; Tree partitioning; Video coding standard; Video signal processing | English | 2021 | 2021 | 10.1109/tmm.2020.3042062 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Measurement of the generalized spin polarizabilities of the neutron in the low-Q² region | Understanding the nucleon spin structure in the regime where the strong interaction becomes truly strong poses a challenge to both experiment and theory. At energy scales below the nucleon mass of about 1 GeV, the intense interaction among the quarks and gluons inside the nucleon makes them highly correlated. Their coherent behaviour causes the emergence of effective degrees of freedom, requiring the application of non-perturbative techniques such as chiral effective field theory(1). Here we present measurements of the neutron's generalized spin polarizabilities that quantify the neutron's spin precession under electromagnetic fields at very low energy-momentum transfer squared down to 0.035 GeV2. In this regime, chiral effective field theory calculations(2-4) are expected to be applicable. Our data, however, show a strong discrepancy with these predictions, presenting a challenge to the current description of the neutron's spin properties. | Sulkosky, Vincent; Peng, Chao; Chen, Jian-ping; Deur, Alexandre; Abrahamyan, Sergey; Aniol, Konrad A.; Armstrong, David S.; Averett, Todd; Bailey, Stephen J.; Beck, Arie; Bertin, Pierre; Butaru, Florentin; Boeglin, Werner; Camsonne, Alexandre; Cates, Gordon D.; Chang, Chia-Cheh; Choi, Seonho; Chudakov, Eugene; Coman, Luminita; Cornejo, Juan C.; Craver, Brandon; Cusanno, Francesco; De Leo, Raffaele; de Jager, Cornelis W.; Denton, Joseph D.; Dhamija, Seema; Feuerbach, Robert; Finn, John M.; Frullani, Salvatore; Fuoti, Kirsten; Gao, Haiyan; Garibaldi, Franco; Gayou, Olivier; Gilman, Ronald; Glamazdin, Alexander; Glashausser, Charles; Gomez, Javier; Hansen, Jens-Ole; Hayes, David; Hersman, F. William; Higinbotham, Douglas W.; Holmstrom, Timothy; Humensky, Thomas B.; Hyde, Charles E.; Ibrahim, Hassan; Iodice, Mauro; Jiang, Xiandong; Kaufman, Lisa J.; Kelleher, Aidan; Keister, Kathryn E.; Kim, Wooyoung; Kolarkar, Ameya; Kolb, Norm; Korsch, Wolfgang; Kramer, Kevin; Kumbartzki, Gerfried; Lagamba, Luigi; Laine, Vivien; Laveissiere, Geraud; Lerose, John J.; Lhuillier, David; Lindgren, Richard; Liyanage, Nilanga; Lu, Hai-Jiang; Ma, Bin; Margaziotis, Demetrius J.; Markowitz, Peter; McCormick, Kathleen R.; Meziane, Mehdi; Meziani, Zein-Eddine; Michaels, Robert; Moffit, Bryan; Monaghan, Peter; Nanda, Sirish; Niedziela, Jennifer; Niskin, Mikhail; Pandolfi, Ronald; Paschke, Kent D.; Potokar, Milan; Puckett, Andrew; Punjabi, Vina A.; Qiang, Yi; Ransome, Ronald D.; Reitz, Bodo; Roche, Rikki; Saha, Arun; Shabetai, Alexander; Sirca, Simon; Singh, Jaideep T.; Slifer, Karl; Snyder, Ryan; Solvignon, Patricia; Stringer, Robert; Subedi, Ramesh; Tobias, William A.; Ton, Ngyen; Ulmer, Paul E.; Urciuoli, Guido Maria; Vacheret, Antonin; Voutier, Eric; Wang, Kebin; Wan, Lu; Wojtsekhowski, Bogdan; Woo, Seungtae; Yao, Huan; Yuan, Jing; Zhan, Xiaohui; Zheng, Xiaochao; Zhu, Lingyan | William & Mary, Williamsburg, VA USA; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Univ Virginia, Charlottesville, VA 22904 USA; Duke Univ, Durham, NC USA; Triangle Univ Nucl Lab, Durham, NC 27706 USA; Argonne Natl Lab, Lemont, IL USA; Yerevan Phys Inst, Yerevan, Armenia; Calif State Univ Los Angeles, Los Angeles, CA 90032 USA; MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA; Univ Blaise Pascal, LPC Clermont Ferrand, CNRS, IN2P3, Aubiere, France; Temple Univ, Philadelphia, PA 19122 USA; Florida Int Univ, Miami, FL 33199 USA; Univ Maryland, College Pk, MD 20742 USA; Ist Nazl Fis Nucl, Rome, Italy; Ist Nazl Fis Nucl, Sez Bari, Bari, Italy; Univ Bari, Bari, Italy; Longwood Univ, Farmville, VA USA; Univ Kentucky, Lexington, KY USA; Ist Super Sanita, Rome, Italy; Rutgers State Univ, Piscataway, NJ USA; Kharkov Inst Phys & Technol, Kharkov, Ukraine; Old Dominion Univ, Norfolk, VA USA; Univ New Hampshire, Durham, NH 03824 USA; Cairo Univ, Giza, Egypt; Univ Massachusetts, Amherst, MA 01003 USA; Kyungpook Natl Univ, Daegu, South Korea; Univ Saskatchewan, Saskatoon, SK, Canada; CEA Saclay, DAPHNIA, SPhN, Gif Sur Yvette, France; Univ Sci & Technol China, Dept Modern Phys, Hefei, Peoples R China; Randolph Macon Coll, Ashland, VA 23005 USA; Univ Ljubljana, Jozef Stefan Inst, Ljubljana, Slovenia; Norfolk State Univ, Norfolk, VA USA; Florida State Univ, Tallahassee, FL 32306 USA; Univ Ljubljana, Fac Math & Phys, Ljubljana, Slovenia; Kent State Univ, Kent, OH 44242 USA; Univ Joseph Fourier, LPSC, INPG, CNRS,IN2P3, Grenoble, France | Snyder, Ryan/MSX-7121-2025; Markowitz, Pete/AAC-3382-2020; Cates, Gordon/HQY-5058-2023; Hyde, Charles/W-9190-2018; Deur, Alexandre/H-9778-2019; weng, xin/HNQ-8347-2023; Chen, Jianping/F-2124-2019; Higinbotham, Douglas/J-9394-2014; Singh, Jaideep/H-2346-2013; Paschke, Kent/JCE-3864-2023; Yuan, Jing/GSE-5499-2022; Ibrahim, Hassan/HKM-5229-2023; Zheng, Xiaochao/LZH-2152-2025; Peng, Chao/MTG-0314-2025; Qiang, Yihua/MIQ-6852-2025 | 9241036200; 55710882600; 57216185967; 6604025441; 36717446600; 57223004530; 7404406991; 7004322920; 55798374900; 57202886386; 7101872853; 15822025400; 57218357388; 9840900600; 7006184114; 57226047455; 57199723894; 19638695300; 6505489675; 36122550000; 12244778800; 56210335900; 7004824201; 57225335327; 57216548131; 7003742031; 35227196100; 57216378708; 7007181460; 12244508300; 7402970950; 35946709100; 6602615038; 36046351900; 6602223200; 6701469450; 36639255800; 7404333236; 57197211573; 7004338858; 6701771992; 7004688871; 35227409300; 57204617911; 56212494700; 56235516500; 59836540900; 8786682700; 7006091310; 57221140349; 35227558900; 8834538100; 7003765392; 7003994135; 7201848138; 7004406182; 6701825730; 55587445600; 6602663675; 57223019091; 15842326600; 7005261571; 57216595166; 59441430600; 57221138198; 57223012802; 16067011300; 57206512236; 22985979600; 24500876300; 7005666681; 8834540300; 7102503371; 22962910200; 59270833100; 57216547799; 55826646100; 7003678572; 8258895300; 15822827100; 6603966777; 12244665700; 7003611554; 9241034800; 7006428313; 58279958000; 59829838400; 34573433700; 55574202846; 7003298969; 57210753889; 6504491759; 59877771200; 12244769000; 6603157705; 57203168632; 7004424167; 7004674487; 8909873500; 6603350317; 57208293125; 57216549137; 6701552350; 57473917300; 55419611700; 59103619500; 15823233800; 57216598726; 57198444774 | deurpam@jlab.org; | NATURE PHYSICS | NAT PHYS | 1745-2473 | 1745-2481 | 17 | 6 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2021 | 19.684 | 4.1 | 0.8 | 2025-07-30 | 13 | 13 | VIRTUAL COMPTON-SCATTERING; SUM-RULES; NUCLEON; MOMENTS; PROTON | Degrees of freedom (mechanics); Electromagnetic fields; Chiral effective-field theory; Effective degrees of freedoms; Energy momentum transfer; Highly-correlated; Nonperturbative techniques; Nucleon spin structure; Spin polarizabilities; Strong interaction; Neutrons | English | 2021 | 2021-06 | 10.1038/s41567-021-01245-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Measurement of the proton spin structure at long distances | Measurements of the proton's spin structure in experiments scattering a polarized electron beam off polarized protons in regions of low momentum transfer squared test predictions from chiral effective field theory of the strong interaction. Measuring the spin structure of protons and neutrons tests our understanding of how they arise from quarks and gluons, the fundamental building blocks of nuclear matter. At long distances, the coupling constant of the strong interaction becomes large, requiring non-perturbative methods to calculate quantum chromodynamics processes, such as lattice gauge theory or effective field theories. Here we report proton spin structure measurements from scattering a polarized electron beam off polarized protons. The spin-dependent cross-sections were measured at large distances, corresponding to the region of low momentum transfer squared between 0.012 and 1.0 GeV2. This kinematic range provides unique tests of chiral effective field theory predictions. Our results show that a complete description of the nucleon spin remains elusive, and call for further theoretical works, for example, in lattice quantum chromodynamics. Finally, our data extrapolated to the photon point agree with the Gerasimov-Drell-Hearn sum rule, a fundamental prediction of quantum field theory that relates the anomalous magnetic moment of the proton to its integrated spin-dependent cross-sections. | Zheng, X.; Deur, A.; Kang, H.; Kuhn, S. E.; Ripani, M.; Zhang, J.; Adhikari, K. P.; Adhikari, S.; Amaryan, M. J.; Atac, H.; Avakian, H.; Barion, L.; Battaglieri, M.; Bedlinskiy, I.; Benmokhtar, F.; Bianconi, A.; Biselli, A. S.; Boiarinov, S.; Bondi, M.; Bossu, F.; Bosted, P.; Briscoe, W. J.; Brock, J.; Brooks, W. K.; Bulumulla, D.; Burkert, V. D.; Carlin, C.; Carman, D. S.; Carvajal, J. C.; Celentano, A.; Chatagnon, P.; Chetry, T.; Chen, J. -P.; Choi, S.; Ciullo, G.; Clark, L.; Cole, P. L.; Contalbrigo, M.; Crede, V.; D'Angelo, A.; Dashyan, N.; De Vita, R.; Defurne, M.; Diehl, S.; Djalali, C.; Drozdov, V. A.; Dupre, R.; Ehrhart, M.; El Alaoui, A.; El Fassi, L.; Elouadrhiri, L.; Eugenio, P.; Fedotov, G.; Fegan, S.; Fersch, R.; Filippi, A.; Forest, T. A.; Ghandilyan, Y.; Gilfoyle, G. P.; Giovanetti, K. L.; Girod, F. -X.; Glazier, D. I.; Gothe, R. W.; Griffioen, K. A.; Guidal, M.; Guler, N.; Guo, L.; Hafidi, K.; Hakobyan, H.; Hattawy, M.; Hayward, T. B.; Heddle, D.; Hicks, K.; Hobart, A.; Holmstrom, T.; Holtrop, M.; Ilieva, Y.; Ireland, D. G.; Isupov, E. L.; Jo, H. S.; Joo, K.; Joosten, S.; Keith, C. D.; Keller, D.; Khanal, A.; Khandaker, M.; Kim, C. W.; Kim, W.; Klein, F. J.; Kripko, A.; Kubarovsky, V.; Lanza, L.; Leali, M.; Lenisa, P.; Livingston, K.; Long, E.; MacGregor, I. J. D.; Markov, N.; Marsicano, L.; Mascagna, V.; McKinnon, B.; Meekins, D. G.; Mineeva, T.; Mirazita, M.; Mokeev, V.; Mullen, C.; Nadel-Turonski, P.; Neupane, K.; Niccolai, S.; Osipenko, M.; Ostrovidov, A. I.; Paolone, M.; Pappalardo, L.; Park, K.; Pasyuk, E.; Phelps, W.; Phillips, S. K.; Pogorelko, O.; Poudel, J.; Prok, Y.; Raue, B. A.; Ritman, J.; Rizzo, A.; Rosner, G.; Rossi, P.; Rowley, J.; Sabatie, F.; Salgado, C.; Schmidt, A.; Schumacher, R. A.; Seely, M. L.; Sharabian, Y. G.; Shrestha, U.; Sirca, S.; Slifer, K.; Sparveris, N.; Stepanyan, S.; Strakovsky, I. I.; Strauch, S.; Sulkosky, V.; Tyler, N.; Ungaro, M.; Venturelli, L.; Voskanyan, H.; Voutier, E.; Watts, D. P.; Wei, X.; Weinstein, L. B.; Wood, M. H.; Yale, B.; Zachariou, N.; Zhao, Z. W. | Univ Virginia, Charlottesville, VA 22904 USA; Thomas Jefferson Natl Accelerator Facil, Newport News, VA 23606 USA; Seoul Natl Univ, Seoul, South Korea; Old Dominion Univ, Norfolk, VA USA; INFN, Sez Genova, Genoa, Italy; Mississippi State Univ, Mississippi State, MS 39762 USA; Florida Int Univ, Miami, FL 33199 USA; Temple Univ, Philadelphia, PA 19122 USA; INFN, Sez Ferrara, Ferrara, Italy; Kurchatov Inst ITEP, Natl Res Ctr, Moscow, Russia; Duquesne Univ, Pittsburgh, PA 15219 USA; Univ Brescia, Brescia, Italy; INFN, Sez Pavia, Pavia, Italy; Fairfield Univ, Fairfield, CT 06430 USA; Univ Paris Saclay, IRFU, CEA, Gif Sur Yvette, France; Coll William & Mary, Williamsburg, VA 23185 USA; George Washington Univ, Washington, DC USA; Univ Tecn Federico Santa Maria, Valparaiso, Chile; Univ Paris Saclay, IJCLab, CNRS, IN2P3, Orsay, France; Univ Ferrara, Ferrara, Italy; Univ Glasgow, Glasgow, Lanark, Scotland; Lamar Univ, Beaumont, TX 77710 USA; Idaho State Univ, Pocatello, ID 83209 USA; Florida State Univ, Tallahassee, FL 32306 USA; INFN, Sez Roma Tor Vergata, Rome, Italy; Univ Roma Tor Vergata, Rome, Italy; Yerevan Phys Inst, Yerevan, Armenia; Univ Giessen, Phys Inst 2, Giessen, Germany; Univ Connecticut, Storrs, CT USA; Ohio Univ, Athens, OH 45701 USA; Univ South Carolina, Columbia, SC 29208 USA; Lomonosov Moscow State Univ, Skobeltsyn Inst Nucl Phys, Moscow, Russia; Argonne Natl Lab, 9700 S Cass Ave, Argonne, IL 60439 USA; Univ York, York, N Yorkshire, England; Christopher Newport Univ, Newport News, VA 23606 USA; INFN, Sez Torino, Turin, Italy; Univ Richmond, Richmond, VA 23173 USA; James Madison Univ, Harrisonburg, VA 22807 USA; Univ New Hampshire, Durham, NH 03824 USA; Kyungpook Natl Univ, Daegu, South Korea; Norfolk State Univ, Norfolk, VA USA; Catholic Univ Amer, Washington, DC 20064 USA; Rensselaer Polytech Inst, Troy, NY USA; Univ Insubria, Como, Italy; INFN, Lab Nazl Frascati, Frascati, Italy; Inst Kernphys Juelich, Julich, Germany; Carnegie Mellon Univ, Pittsburgh, PA 15213 USA; Univ Ljubljana, Slovenia Jozef Stefan Inst, Ljubljana, Slovenia; Canisius Coll, Buffalo, NY 14208 USA; Hampton Univ, Hampton, VA 23668 USA; Idaho State Univ, Pocatello, ID 83209 USA | ; McKinnon, Bryan/J-2928-2018; Higinbotham, Douglas/J-9394-2014; Joosten, Sylvester/HZL-4182-2023; Drozdov, Vadim/E-5456-2012; Holtrop, Maurik/A-9017-2010; Filippi, Alessandra/AAE-9322-2020; Mascagna, Valerio/HLQ-1103-2023; Zheng, Xiaochao/LZH-2152-2025; Jo, Hyon-Suk/HGC-7070-2022; Celentano, Andrea/JFJ-2728-2023; Ciullo, Giuseppe/X-6539-2018; Filippi, Alessandra/I-9530-2012; Rossi, Patrizia/B-5943-2019; Battaglieri, Marco/I-6262-2018; Khanal, Aaditya/ABI-5610-2020; Lanza, Lucilla/E-6479-2017; Sparveris, Nikolaos/C-4751-2008; Brooks, William/C-8636-2013; Hakobyan, Hayk/JUF-6461-2023; Bozzi, Giuseppe/H-7283-2017; POUDEL, JIWAN/KQU-6557-2024; Rosner, Guenther/ABB-5516-2021; Adikaram, Dasuni/D-1539-2016; Mineeva, Taisiya/MDT-1592-2025; Alaoui, Ahmed/B-4638-2015; Sabatie, Franck/K-9066-2015; Deur, Alexandre/H-9778-2019; Isupov, Evgeny/J-2976-2012; Pappalardo, Luciano/AAB-2380-2021; MacGregor, Ian/D-4072-2011; D'Angelo, Annalisa/A-2439-2012; Long, Elena/HCH-3587-2022; Burkert, Volker/AAF-7395-2020; Marsicano, Luca/KPB-4594-2024; Schumacher, Reinhard/K-6455-2013; Ireland, David/E-8618-2010; Osipenko, Mikhail/N-8292-2015 | 57216598726; 6604025441; 57207380246; 7103392237; 7003515879; 57215210642; 25823658400; 56258456900; 35277104000; 57210826461; 7006613415; 23033257000; 7004520678; 35277104100; 57218527298; 7102358422; 35227021700; 35277071300; 54398256600; 35725064700; 35404427600; 7005532059; 7202009888; 35400106000; 57218357843; 7004440244; 55226389700; 7005853901; 57214364802; 54392656300; 57202987431; 57189889203; 57216185967; 57199723894; 6603765308; 36022213600; 35227101500; 7003468594; 6602900241; 55828029600; 6507987909; 59345445900; 56272524200; 57217562965; 35374416600; 57204172044; 35069234100; 57193421717; 26535686800; 14041647600; 35227171600; 9845148400; 57215092344; 56978985100; 57216999696; 8695796100; 35227189500; 57215024895; 6603686320; 6701352818; 35227280900; 8258896400; 7102183142; 57217000308; 7003432409; 35227288200; 25948329000; 34570410000; 57208726428; 56115055200; 57206656408; 7003821864; 22966851900; 57214681432; 7004688871; 7005060869; 35227424100; 57209456981; 35227460400; 35227429400; 57202638465; 23034837300; 7005417443; 57216594895; 57208691543; 13405022500; 59817767500; 35227558900; 57214026240; 57205462419; 6701392158; 56047689500; 6507646370; 56273696800; 9278396500; 49061311400; 7006040977; 35227617100; 57193833269; 22135531000; 35227669300; 57216997301; 26023453000; 35227656900; 7004546205; 59248746000; 6603294089; 57212715831; 35227746500; 6701825145; 6603112367; 22986163400; 7004207376; 55722196400; 35227791700; 56362788600; 8834541400; 8903140900; 57200602864; 35227871000; 7004527121; 6701495633; 56589489300; 7102538331; 58092074700; 57214597279; 35227896300; 35228024200; 57212416423; 7201653195; 7004734017; 35227996900; 57213706614; 34573433700; 7003298969; 6507906118; 7004491103; 22969481600; 7004321986; 9241036200; 57203722948; 35228099400; 22136651400; 6504161736; 6603350317; 7201539565; 13204321200; 35377851100; 57201559118; 57204955185; 36836386600; 57216598335 | deurpam@jlab.org; | NATURE PHYSICS | NAT PHYS | 1745-2473 | 1745-2481 | 17 | 6 | SCIE | PHYSICS, MULTIDISCIPLINARY | 2021 | 19.684 | 4.1 | 1.74 | 2025-07-30 | 20 | 27 | CHIRAL PERTURBATION-THEORY; GERASIMOV-DRELL-HEARN; SUM-RULE; POLARIZED TARGET; MOMENTS; NEUTRON; POLARIZABILITIES; EVOLUTION; ORDER | High energy physics; Lattice theory; Magnetic moments; Anomalous magnetic moments; Chiral effective-field theory; Effective field theory; Fundamental building blocks; Lattice gauge theory; Lattice quantum chromodynamics; Low momentum transfers; Quantum chromodynamics; Quantum theory | English | 2021 | 2021-06 | 10.1038/s41567-021-01198-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Overcoming therapeutic efficiency limitations against TRAIL-resistant tumors using re-sensitizing agent-loaded trimeric TRAIL-presenting nanocages | Tumor-specific apoptosis-inducing ligands have attracted considerable attention in cancer therapy. But, the evasion of apoptosis by tumors can cause acquired resistance to the therapy. TNF-related apoptosis-inducing ligand (TRAIL) has been investigated as an ideal antitumor agent owing to its inherent tumor cell-specific apoptotic activity. However, there are several barriers to its wider application, including the inability for stable formation of the trimeric structure, poor stability and pharmacokinetics, and differences in the sensitivity of different tumor types. Especially, almost 70% of tumor cells have acquired resistance to TRAIL, leading to failure of TRAIL-based therapeutics in clinical trials. To overcome therapeutic efficiency limitations against TRAIL-resistant tumors, we exploited the characteristic of a naturally derived nanocage that not only delivers TRAIL in its native-like trimeric structure, but also delivers a drug (doxorubicin [DOX]) that re-sensitizes TRAIL-resistant tumor cells. These TRAIL-presenting nanocages (TTPNs) showed high loading efficiency, pH-dependent release profiles, and effective intracellular delivery of the re-sensitizing agent DOX. As a result, DOX-TTPNs efficiently re-sensitized TRAIL-resistant tumor cells to TRAIL-mediated apoptosis in vitro by regulating levels of the TRAIL receptor, DR5, and anti- and pro-apoptotic proteins involved in extrinsic and intrinsic apoptosis pathways. We further demonstrated the antitumor efficacy of DOX-TTPNs in vivo, showing that even at a very low dose, the incorporated DOX successfully re-sensitized tumors to the apoptotic effects of TRAIL, underscoring the potential of this platform as an antitumor agent. Given that other homotrimeric TNF superfamily ligands and immunotherapeutic agents can be substituted for TRAIL ligand and re-sensitizing drugs on the surface and in the inner cavity of the nanocage, respectively, this platform is potentially suitable for development of a broad range of anticancer or immunotherapeutic combinations. | Je, Hyeonwoo; Nam, Gi-Hoon; Kim, Gi Beom; Kim, Wonjun; Kim, Soo Rin; Kim, In-San; Lee, Eun Jung | Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, 80 Daehak Ro, Daegu 41566, South Korea | Kim, Soo Rin/X-2192-2019; Lee, Seung Eun/ABG-1607-2021 | 57221780080; 57192919427; 57197865834; 57221789815; 36659584200; 34770432800; 57239965200 | iskim14@kist.re.kr;eunjunglee@knu.ac.kr; | JOURNAL OF CONTROLLED RELEASE | J CONTROL RELEASE | 0168-3659 | 1873-4995 | 331 | SCIE | CHEMISTRY, MULTIDISCIPLINARY;PHARMACOLOGY & PHARMACY | 2021 | 11.467 | 4.1 | 1.74 | 2025-07-30 | 17 | 20 | Protein Nanocage; Tumor-specific apoptosis; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); Resistance; Re-sensitization | Protein Nanocage; Re-sensitization; Resistance; Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); Tumor-specific apoptosis | Apoptosis; Cell Line, Tumor; Doxorubicin; Humans; Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Cell death; Controlled drug delivery; Efficiency; Ligands; Organic polymers; Targeted drug delivery; buffer; caspase 3; caspase 8; death receptor 5; doxorubicin; monomer; nanocage; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; protein bcl xl; tumor necrosis factor related apoptosis inducing ligand; tumor necrosis factor related apoptosis inducing ligand receptor; X linked inhibitor of apoptosis; tumor necrosis factor related apoptosis inducing ligand; tumor necrosis factor related apoptosis inducing ligand receptor; Acquired resistance; Anti-tumor efficacy; Apoptosis pathways; Apoptotic activity; Intracellular delivery; Ph-dependent release; Therapeutic efficiency; Trimeric structure; animal experiment; animal model; apoptosis; Article; cell death; cell membrane; cell viability; comparative study; controlled study; elution; endocytosis; fluorescence intensity; fluorescence microscopy; Hep-G2 cell line; HT-29 cell line; human; human cell; in vitro study; internalization (cell); lysosome; MCF-7 cell line; mouse; nonhuman; pH; photon correlation spectroscopy; physical chemistry; polyacrylamide gel electrophoresis; priority journal; size exclusion chromatography; transmission electron microscopy; tumor volume; TUNEL assay; neoplasm; tumor cell line; Tumors | English | 2021 | 2021-03-10 | 10.1016/j.jconrel.2021.01.016 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Unsupervised Moving Object Detection in Complex Scenes Using Adversarial Regularizations | Moving object detection (MOD) is a fundamental step in many high-level vision-based applications, such as human activity analysis, visual object tracking, autonomous vehicles, surveillance, and security. Most of the existing MOD algorithms observe performance degradation in the presence of complex scenes containing camouflage objects, shadows, dynamic backgrounds, and varying illumination conditions, and captured by static cameras. To appropriately handle these challenges, we propose a Generative Adversarial Network (GAN) based on a moving object detection algorithm, called MODGAN. In the proposed algorithm, scene-specific GANs are trained in an unsupervised MOD setting, thereby enabling the algorithm to learn generating background sequences using input from uniformly distributed random noise samples. In addition to adversarial loss, during training, norm-based loss in the image space and discriminator feature-space is also minimized between the generated images and the training data. The additional losses enable the generator to learn subtle background details, resulting in a more realistic complex scene generation. During testing, a novel back-propagation based algorithm is used to generate images with statistics similar to the test images. More appropriate random noise samples are searched by directly minimizing the loss function between the test and generated images both in the image and discriminator feature-spaces. The network is not updated in this step; only the input noise samples are iteratively modified to minimize the loss function. Moreover, motion information is used to ensure that this loss is only computed on small-motion pixels. A novel dataset containing outdoor time-lapsed images from dawn to dusk with a full illumination variation cycle is also proposed to better compare the MOD algorithms in outdoor scenes. Accordingly, extensive experiments on five benchmark datasets and comparison with 30 existing methods demonstrate the strength of the proposed algorithm. | Sultana, Maryam; Mahmood, Arif; Jung, Soon Ki | Kyungpook Natl Univ, Sch Comp Sci & Engn, Virtual Real Lab, Daegu 41566, South Korea; Informat Technol Univ, Dept Comp Sci, Lahore 54000, Pakistan | Jung, Soon Ki/P-7687-2018; Mahmood, Arif/R-7949-2019 | 57196402440; 55636036300; 57226791905 | maryam@knu.ac.kr;arif.mahmood@itu.edu.pk;skjung@knu.ac.kr; | IEEE TRANSACTIONS ON MULTIMEDIA | IEEE T MULTIMEDIA | 1520-9210 | 1941-0077 | 23 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;COMPUTER SCIENCE, SOFTWARE ENGINEERING;TELECOMMUNICATIONS | 2021 | 8.182 | 4.1 | 1.78 | 2025-07-30 | 28 | 33 | Generative adversarial networks; Gallium nitride; Lighting; Heuristic algorithms; Object detection; Minimization; Optical losses; Moving object detection; background subtra-ction; generative adversarial networks | BACKGROUND SUBTRACTION; VIDEO SURVEILLANCE; LOW-RANK; SEPARATION; MODEL | background subtra-ction; generative adversarial networks; Moving object detection | Backpropagation; Complex networks; Iterative methods; Object recognition; Object tracking; Adversarial networks; Human activity analysis; Illumination conditions; Illumination variation; Moving object detection algorithms; Moving-object detection; Performance degradation; Visual object tracking; Object detection | English | 2021 | 2021 | 10.1109/tmm.2020.3006419 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Are female users equally active? An empirical study of the gender imbalance in Korean online news commenting | Because online news is pervasive and online comments provide space for people to express their opinions and participate in open discussions, they affect public opinion. However, at least in Korea, male users seem not only to be more active in consuming online news but also in commenting online. Many previous studies have investigated the gender imbalance in news consumption of not only traditional media but also online media. Although a few studies explored gender differences in online comments on news, no study has investigated such gender differences using actual data on the basic profiles of commenters. To fill the gap between previous studies and reality and address the gender imbalance in online news comments and public opinion, this study examined the differences between male and female online news commenters. Furthermore, using actual data provided by Naver, the dominant Internet portal in Korea, this study analyzed the characteristics of female news commenters and those of news content where female users most actively commented. This study found that-at least in Korea-fewer women comment on news, they are less active than men, and that there is a difference between younger and older women. This study also found that people write more comments in a day as their age increases and the gender differences decrease with age. | Baek, Hyunmi; Lee, Saerom; Kim, Seongcheol | Korea Univ, Sch Media & Commun, 145 Anam Dong, Seoul 02841, South Korea; Kyungpook Natl Univ, Sch Business Adm, 80 Daehakro, Daegu 41566, South Korea | Baek, Hye/T-2076-2019 | 57543501600; 56023428700; 55718730600 | hiddentrees@korea.ac.kr; | TELEMATICS AND INFORMATICS | TELEMAT INFORM | 0736-5853 | 62 | SSCI | INFORMATION SCIENCE & LIBRARY SCIENCE | 2021 | 9.14 | 4.2 | 0.38 | 2025-07-30 | 5 | 4 | Online news; News comments; Public opinion; Gender difference; Gender imbalance; Age; Equal participation | COMMUNICATION; PARTICIPATION; AUDIENCE | Age; Equal participation; Gender difference; Gender imbalance; News comments; Online news; Public opinion | Social aspects; Empirical studies; Gender differences; Internet portals; News content; Online media; Online news; Public opinions; Behavioral research | English | 2021 | 2021-09 | 10.1016/j.tele.2021.101635 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Expanding the effectiveness of screening | Song, Minsoo; Hwang, Gil Tae | Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr NDDC, Daegu, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu, South Korea | Hwang, Gil Tae/L-6502-2017 | 56643651800; 7202676087 | msong@dgmif.re.kr;giltae@knu.ac.kr; | NATURE CHEMISTRY | NAT CHEM | 1755-4330 | 1755-4349 | 13 | 6 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2021 | 24.274 | 4.2 | 0.3 | 2025-07-30 | 1 | 1 | Mass Screening; mass screening | English | 2021 | 2021-06 | 10.1038/s41557-021-00690-6 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Numerically simulated behavior of radiative Fe3O4 and multi-walled carbon nanotube hybrid nanoparticle flow in presence of Lorentz force | Free convection in hybrid nanomaterial-saturated permeable media is crucial in various engineering applications. The present study aims to investigate the free convection of an aqueous-based hybrid nanomaterial through a zone under the combined effect of the Lorentz force and radiation. The natural convection of the hybrid nanomaterial is modeled by implementing a control volume finite element method (CVFEM)-based code, whereas Darcy assumptions are used to model the porosity terms in the momentum buoyancy equation involving the average Nusselt number Nu(ave), flow streamlines, and isotherm profiles. A formula for estimating Nu(ave) is proposed. The results show that the magnetic force retards the flow, and the fluid tends to attract the magnetic field source. Nu(ave) is directly correlated with the Rayleigh number and radiation; however, it is indirectly dependent on the Hartmann number. Conduction is the dominant mode at larger Darcy and Hartmann numbers. | Shehzad, S. A.; Sheikholeslami, M.; Ambreen, T.; Saleem, A.; Shafee, A. | COMSATS Univ Islamabad, Dept Math, Sahiwal 57000, Pakistan; Babol Noshirvani Univ Technol, Renewable Energy Syst & Nanofluid Applicat Heat T, Babol 4714871167, Iran; Babol Noshirvani Univ Technol, Dept Mech Engn, Babol 4714871167, Iran; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Duy Tan Univ, Inst Res & Dev, Da Nang 550000, Vietnam | Sheikholeslami, Mohsen/G-9034-2015; Saleem, Arslan/ABA-5982-2021; Shehzad, Sabir/J-3885-2014 | 42262831200; 54880733100; 57195420431; 57194776354; 57202423343 | ali_qau70@yahoo.com; | APPLIED MATHEMATICS AND MECHANICS-ENGLISH EDITION | APPL MATH MECH-ENGL | 0253-4827 | 1573-2754 | 42 | 3 | SCIE | MATHEMATICS, APPLIED;MECHANICS | 2021 | 3.918 | 4.3 | 0.89 | 2025-07-30 | 11 | 11 | free convection; hybrid nanoparticle; Darcy porous space; Hartmann number; radiation; O361; 76Sxx; 76Bxx | Darcy porous space; free convection; Hartmann number; hybrid nanoparticle; O361; radiation | Flow of fluids; Iron oxides; Lorentz force; Magnetic fields; Magnetite; Natural convection; Buoyancy equations; Control-volume finite-element methods; Engineering applications; Flow streamlines; Hartmann numbers; Hybrid nanomaterials; Magnetic field sources; Simulated behaviors; Multiwalled carbon nanotubes (MWCN) | English | 2021 | 2021-03 | 10.1007/s10483-021-2693-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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