2025 연구성과 (16 / 151)
※ 컨트롤 + 클릭으로 열별 다중 정렬 가능합니다.
Excel 다운로드
| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ○ | Article | Two-Degree-Of-Freedom-Based Feedback Control Design for Semi-Markovian Jump Systems via Quadratic Function Negative Determination Approach | This article addresses a state tracking control problem for a class of semi-Markovian jump linear systems (SMJLSs) with time-varying delays, uncertainties, and disturbances. In order to achieve the desired tracking performance, a lumped disturbance estimator manages the effects of disturbance signals and uncertainties while simultaneously estimating the unknown external input signal through the proper bandwidth selection of the low-pass filter and model perturbations. Then, a quadratic delay product term is then incorporated into the construction of an suitable Lyapunov–Krasovskii functional candidate. In order to guarantee the stability of the examined SMJLSs under the proposed two-degree-of-freedom-based control, adequate conditions are derived in the form of linear matrix inequalities using the generalized reciprocally convex combination lemma. Finally, simulation results and comparative results are given to illustrate the effectiveness and advantages of the proposed control scheme. © 2025 John Wiley & Sons Ltd. | Blessy, A.; Harshavarthini, S.; Sathiyaraj, T.; Zhu, Quanxin; Lee, S.M. | Department of Mathematics, School of Advanced Sciences, VIT University, Chennai, India; Department of Mathematics, School of Advanced Sciences, VIT University, Chennai, India, Institute of Actuarial Science and Data Analytics, UCSI University, Kuala Lumpur, Malaysia; Institute of Actuarial Science and Data Analytics, UCSI University, Kuala Lumpur, Malaysia; School of Mathematics and Statistics, Hunan Normal University, Hunan, Changsha, China; School of Electronic and Electrical Engineering, Kyungpook National University, Daegu, South Korea | 59950617700; 57204646660; 57015474500; 8689808100; 59510733500 | varthiniksp@gmail.com; | International Journal of Robust and Nonlinear Control | INT J ROBUST NONLIN | 1049-8923 | 1099-1239 | SCIE | AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;MATHEMATICS, APPLIED | 2024 | 3.2 | 3.6 | N/A | 0 | negative-definiteness conditions; quadratic polynomial function; semi-Markovian jump linear systems; tracking control design; uncertainty and disturbance estimator | Degrees of freedom (mechanics); Feedback control; Linear systems; Low pass filters; Markov processes; Navigation; Quadratic programming; Robustness (control systems); Time varying control systems; Uncertainty analysis; Condition; Control design; Markovian jump linear systems; Negative-definiteness condition; Quadratic polynomial functions; Semi-markovian jump linear system; Tracking control design; Tracking controls; Two-degree-of-freedom; Uncertainty and disturbance estimators; Linear matrix inequalities | English | Article in press | 2025 | 10.1002/rnc.70026 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | A Feature-Aware Approach to Acupoint Compatibility Prediction Using Residual Graph Attention Networks and Matrix Factorization | Compatibility among acupoints is a fundamental principle in acupuncture treatment within traditional Chinese medicine, playing a vital role in enhancing the effectiveness and scope of therapeutic interventions. With the increasing availability of acupuncture-related data, link prediction offers a data-driven approach that facilitates the evidence-based exploration and validation of acupoint compatibilities. However, existing link prediction methods often focus on mapping acupoints and their compatibility relationships into lower-dimensional spaces. These approaches can overlook essential acupoint features and make the predictions susceptible to noise interference. To address these challenges, we propose a novel acupoint compatibility prediction model based on a Feature-Aware Residual Graph Attention Network and Matrix Factorization (FRGATMF). Our model introduces a feature-aware connectivity fusion strategy that integrates acupoint attributes with structural information to enrich acupoint representations. Following this, a deep non-negative matrix factorization approach is employed to construct a denoised feature matrix. This matrix is processed through a residual graph attention network to derive comprehensive and effective node embeddings, which are crucial for accurate link prediction. Experimental results on the acupuncture dataset, along with three public datasets, demonstrate that FRGATMF significantly outperforms seven existing comparison models across various evaluation metrics. Additionally, link prediction can identify previously unconsidered or undocumented acupoint combinations that may offer better therapeutic results, thus expanding the range of treatment options and highlighting its potential in improving the prediction of acupoint compatibility relationships. | Li, Ruiling; Pan, Ying; Wu, Song; Ma, Li; Peng, Limei | Hubei Univ Chinese Med, Sch Informat Engn, Wuhan 430065, Peoples R China; Hubei Univ Chinese Med, Sch Acupuncture Moxibust & Orthoped, Wuhan 430065, Peoples R China; Kyungpook Natl Univ, Sch Comp Sci & Engn, Daegu 41566, South Korea | li, ruiling/LLK-5543-2024 | 58087406400; 59521752800; 56161566600; 58452680000; 59510719200 | ling113@stmail.hbucm.edu.cn; 3410572415@qq.com; 1297@hbucm.edu.cn; mary0807@hbucm.edu.cn; auroraplm@knu.ac.kr; | IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS | IEEE J BIOMED HEALTH | 2168-2194 | 2168-2208 | 29 | 5 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MATHEMATICAL & COMPUTATIONAL BIOLOGY;MEDICAL INFORMATICS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 6.8 | 3.7 | 0 | 2025-05-07 | 0 | 0 | Predictive models; Acupuncture; Noise; Drugs; Autoencoders; Adaptation models; Semantics; Prediction algorithms; Diseases; Biological system modeling; Acupoint compatibility; deep non-negative matrix factorization; residual graph attention network; link prediction | Acupoint compatibility; deep non-negative matrix factorization; link prediction; residual graph attention network | Acupuncture Points; Acupuncture Therapy; Algorithms; Databases, Factual; Humans; Medicine, Chinese Traditional; Neural Networks, Computer; Acupuncture; Graph embeddings; Matrix algebra; Non-negative matrix factorization; Acupoint compatibility; Acupoints; Deep non-negative matrix factorization; Fundamental principles; Link prediction; Matrix factorizations; Nonnegative matrix factorization; Residual graph attention network; Therapeutic intervention; Traditional Chinese Medicine; acupuncture; acupuncture point; adult; article; attention network; benchmarking; Chinese medicine; controlled study; drug interaction; electric potential; evidence based practice; female; human; male; noise; non-negative matrix factorization; prediction; therapy; acupuncture; algorithm; artificial neural network; factual database; procedures; Prediction models | English | 2025 | 2025-05 | 10.1109/jbhi.2024.3525040 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Adaptive Metadata-Guided Supervised Contrastive Learning for Domain Adaptation on Respiratory Sound Classification | Despite considerable advancements in deep learning, optimizing respiratory sound classification (RSC) models remains challenging. This is partly due to the bias from inconsistent respiratory sound recording processes and imbalanced representation of demographics, which leads to poor performance when a model trained with the dataset is applied to real-world use cases. RSC datasets usually include various metadata attributes describing certain aspects of the data, such as environmental and demographic factors. To address the issues caused by bias, we take advantage of the metadata provided by RSC datasets and explore approaches for metadata-guided domain adaptation. We thoroughly evaluate the effect of various metadata attributes and their combinations on a simple metadata-guided approach, but also introduce a more advanced method that adaptively rescales the suitable metadata combinations to improve domain adaptation during training. The findings indicate a robust reduction in domain dependency and improvement in detection accuracy on both ICBHI and our own dataset. Specifically, the implementation of our proposed methods led to an improved score of 84.97%, which signifies a substantial enhancement of 7.37% compared to the baseline model. © 2013 IEEE. | Kim, June-Woo; Toikkanen, Miika; Jalali, Amin; Kim, Minseok; Han, Hye-Ji; Kim, Hyunwoo; Shin, Wonwoo; Jung, Ho-Young; Kim, Kyunghoon | Kyungpook National University, Department of Artificial Intelligence, Daegu, South Korea, MODULABS, RSC Lab, South Korea; MODULABS, RSC Lab, South Korea; Queen's University, Department of Electrical and Computer Engineering, Ingenuity Labs Research Institute, Kingston, Canada; Meta, United States; Seoul National University Bundang Hospital, Department of Pediatrics, Seongnam, South Korea; Seoul National University Bundang Hospital, Department of Pediatrics, Seongnam, South Korea; Seoul National University Bundang Hospital, Department of Pediatrics, Seongnam, South Korea; Kyungpook National University, Department of Artificial Intelligence, Daegu, South Korea; Seoul National University Bundang Hospital, Department of Pediatrics, Seongnam, South Korea, Seoul National University College of Medicine, Department of Pediatrics, Seoul, South Korea | 57219550643; 57286454000; 57022190400; 59656081000; 57387033400; 59655289700; 59656081100; 57198760619; 57201444315 | hoyjung@knu.ac.kr; | IEEE Journal of Biomedical and Health Informatics | IEEE J BIOMED HEALTH | 2168-2194 | 2168-2208 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;MATHEMATICAL & COMPUTATIONAL BIOLOGY;MEDICAL INFORMATICS;COMPUTER SCIENCE, INFORMATION SYSTEMS | 2024 | 6.8 | 3.7 | 0 | 2025-05-07 | 0 | adaptive loss scaling; domain adaptation; metadata; Respiratory sound classification; supervised contrastive learning | English | Article in press | 2025 | 10.1109/jbhi.2025.3545159 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Letter | Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke | Lee, Jin Soo; Lee, Ji Sung; Ahn, Seong Hwan; Kang, Hyun Goo; Song, Tae-Jin; Shin, Dong-Ick; Bae, Hee-Joon; Kim, Chang Hun; Heo, Sung Hyuk; Cha, Jae-Kwan; Lee, Yeong Bae; Kim, Eung Gyu; Park, Man Seok; Park, Hee-Kwon; Kim, Jinkwon; Yu, Sungwook; Mo, Heejung; Il Sohn, Sung; Kwon, Jee Hyun; Kim, Jae Guk; Kim, Young Seo; Choi, Jay Chol; Hwang, Yang-Ha; Jung, Keun Hwa; Kim, Soo-Kyoung; Seo, Woo Keun; Seo, Jung Hwa; Yoo, Joonsang; Chang, Jun Young; Park, Mooseok; Yum, Kyu Sun; San An, Chun; Gwag, Byoung Joo; Choi, Dennis W.; Hong, Ji Man; Kwon, Sun U. | Ajou Univ, Med Ctr, Sch Med, Dept Neurol, 164 Worldcup Ro, Suwon 16499, South Korea; Univ Ulsan, Coll Med, Clin Res Ctr, Asan Med Ctr, Seoul, South Korea; Chosun Univ, Chosun Univ Hosp, Coll Med, Dept Neurol, Gwangju, South Korea; Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Dept Neurol,Biomed Res Inst, Jeonju, South Korea; Ewha Womans Univ, Seoul Hosp, Dept Neurol, Coll Med, Seoul, South Korea; Chungbuk Natl Univ, Chungbuk Natl Univ Hosp, Coll Med, Dept Neurol, Cheongju, South Korea; Seoul Natl Univ, Bundang Hosp, Coll Med, Dept Neurol, Seongnam, South Korea; Gyeongsang Natl Univ, Gyeongsang Natl Univ Hosp, Dept Neurol, Sch Med, Jinju, South Korea; Kyung Hee Univ, Kyung Hee Univ Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Dong A Univ, Dong A Univ Hosp, Coll Med, Dept Neurol, Busan, South Korea; Gachon Univ, Coll Med, Gil Med Ctr, Dept Neurol, Incheon, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Dept Neurol, Busan, South Korea; Chonnam Natl Univ, Chonnam Natl Univ Hosp, Med Sch, Dept Neurol, Gwangju, South Korea; Inha Univ, Inha Univ Hosp, Dept Neurol, Coll Med, Incheon, South Korea; Yonsei Univ, Yongin Severance Hosp, Coll Med, Dept Neurol, Yongin, South Korea; Korea Univ, Korea Univ Med, Anam Hosp, Dept Neurol, Seoul, South Korea; Keimyung Univ, Dongsan Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Univ Ulsan, Ulsan Univ Hosp, Coll Med, Dept Neurol, Ulsan, South Korea; Eulji Univ, Daejeon Eulji Med Ctr, Sch Med, Dept Neurol, Daejeon, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Sch Med, Dept Neurol, Iksan, South Korea; Jeju Natl Univ, Jeju Natl Univ Hosp, Dept Neurol, Coll Med, Jeju, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Neurol, Daegu, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Neurol, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Dept Neurol, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul, South Korea; GNT Pharm Co Ltd, Yongin, South Korea; Stony Brook Univ, Sch Med, Dept Neurol, Stony Brook, NY, USA | Heo, Sung/P-3529-2019; Hong, Ji Man/AAE-2686-2022; Seo, Kwonduk/HLG-9100-2023; Shin, Dong-Ick/JPK-0914-2023 | 59936432900; 57217244570; 59683320400; 59672460400; 55507164200; 23989448700; 7103223963; 59546897500; 59664072000; 59683030400; 59917517300; 59896017700; 59683102500; 8505152100; 37090736900; 56144716300; 57189386173; 59682945500; 26661940800; 59088002100; 57214230759; 7501392645; 7402311308; 58600029700; 59935770900; 22981667600; 59659772200; 55261162200; 59683246100; 56428268200; 59936433000; 57203062100; 59935771000; 7401643634; 59674899700; 7402624264 | jinsoo22@gmail.com; | JOURNAL OF STROKE | J STROKE | 2287-6391 | 2287-6405 | 27 | 2 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2024 | 8.6 | 3.7 | N/A | 0 | 0 | ISCHEMIC-STROKE | nelonemdaz; aged; atrial fibrillation; blood clot lysis; brain blood flow; brain ischemia; brain region; catheter aspiration; cerebrovascular accident; clinical outcome; computer assisted tomography; coronary artery disease; diabetes mellitus; emergency ward; female; human; hyperlipidemia; hypertension; Letter; neuroprotection; percutaneous thrombectomy; Rankin scale; smoking; tissue injury; treatment outcome | English | 2025 | 2025-05 | 10.5853/jos.2024.05113 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial | Background and Purpose The Treat Stroke to Target (TST) was a randomized clinical trial involving French and Korean patients demonstrating that a lower low-density lipoprotein cholesterol (LDL-C, <70 mg/dL) target group (LT) experienced fewer cerebro-cardiovascular events than a higher target (90-110 mg/dL) group (HT). However, whether these results can be applied to Asian patients with different ischemic stroke subtypes remains unclear. Methods Patients from 14 South Korean centers were analyzed separately. Patients with ischemic stroke or transient ischemic attack with evidence of atherosclerosis were randomized into LT and HT groups. The primary endpoint was a composite of ischemic stroke, myocardial infarction, coronary or cerebral revascularization, and cardiovascular death. Results Among 712 enrolled patients, the mean LDL-C level was 71.0 mg/dL in 357 LT patients and 86.1 mg/dL in 355 HT patients. The primary endpoint occurred in 24 (6.7%) of LT and in 31 (8.7%) of HT group patients (adjusted hazard ratio [HR]=0.78; 95% confidence interval [CI]=0.45-1.33, P=0.353). Cardiovascular events alone occurred significantly less frequently in the LT than in the HT group (HR 0.26, 95% CI 0.09-0.80, P=0.019), whereas there were no significant differences in ischemic stroke events (HR 1.12, 95% CI 0.60-2.10, P=0.712). The benefit of LT was less apparent in patients with small vessel disease and intracranial atherosclerosis than in those with extracranial atherosclerosis. Conclusion In contrast to the French TST, the outcomes in Korean patients were neutral. Although LT was more effective in preventing cardiovascular diseases, it was not so in stroke prevention, probably attributed to the differences in stroke subtypes. Further studies are needed to elucidate the efficacy of statins and appropriate LDL-C targets in Asian patients with stroke. | Kwon, Hanim; Ryu, Jae-Chan; Cha, Jae-Kwan; Sung, Sang Min; Song, Tae-Jin; Lee, Kyung Bok; Kim, Eung-Gyu; Kim, Yong-Won; Heo, Ji Hoe; Park, Man Seok; Kang, Kyusik; Lee, Byung-Chul; Hong, Keun-Sik; Bang, Oh Young; Kim, Jei; Kim, Jong S. | Gangnam Smart Neurol Clin, Dept Neurol, Seoul, South Korea; Gimcheon Jeil Hosp, Dept Neurol, Gimcheon, South Korea; Dong A Univ Hosp, Dept Neurol, Busan, South Korea; Pusan Natl Univ Hosp, Coll Med, Dept Neurol, Busan, South Korea; Ewha Womans Univ, Seoul Hosp, Dept Neurol, Seoul, South Korea; Soonchunhyang Univ, Coll Med, Dept Neurol, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Neurol, Busan, South Korea; Kyungpook Natl Univ Hosp, Dept Neurol, Daegu, South Korea; Yonsei Univ, Coll Med, Dept Neurol, Seoul, South Korea; Chonnam Natl Univ Med Sch & Hosp, Dept Neurol, Gwangju, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Sch Med, Dept Neurol, Seoul, South Korea; Hallym Univ, Sacred Heart Hosp, Dept Neurol, Anyang, South Korea; Inje Univ, Ilsan Paik Hosp, Dept Neurol, Ilsan, South Korea; Samsung Med Ctr, Dept Neurol, Seoul, South Korea; Chungnam Natl Univ, Hosp & Coll Med, Dept Neurol & Anat, Daejeon, South Korea; Univ Ulsan, Gangneung Asan Hosp, Dept Neurol, 38 Bangdong Gil, Gangneung 25440, South Korea | Ryu, Jae-Chan/JDC-4421-2023 | 57224782472; 57544694800; 59683030400; 59887695800; 55507164200; 59683179500; 59896017700; 56203298200; 34869576000; 59683102500; 7402222818; 59053582700; 7402515553; 59911011400; 14063316400; 57191682031 | jongskim@amc.seoul.kr; | JOURNAL OF STROKE | J STROKE | 2287-6391 | 2287-6405 | 27 | 2 | SCIE | CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE | 2024 | 8.6 | 3.7 | N/A | 1 | 1 | Ischemic stroke; LDL cholesterol; Target; Prevention; Asia | RISK-FACTORS; ATORVASTATIN; SPARCL | Asia; Ischemic stroke; LDL cholesterol; Prevention; Target | cholesterol; glucose; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; triacylglycerol; adult; Article; atherosclerosis; body mass; brain ischemia; cerebral atherosclerosis; cerebral revascularization; cerebrovascular accident; cerebrovascular disease; computed tomographic angiography; controlled study; coronary artery disease; demographics; diabetes mellitus; diastolic blood pressure; dyslipidemia; follow up; heart infarction; human; hypertension; ischemic stroke; Korean (people); major clinical study; male; nuclear magnetic resonance imaging; questionnaire; randomized controlled trial; smoking; systolic blood pressure; transesophageal echocardiography | English | 2025 | 2025-05 | 10.5853/jos.2025.00409 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Ti3C2 MXene nanosheets integrated cobalt-doped nickel hydroxide heterostructured composite: An efficient electrocatalyst for overall water-splitting | Developing an efficient electrocatalyst for superior electrochemical water splitting (EWS) is crucial for achieving comprehensive hydrogen production. A heterostructured electrocatalyst, free of noble metals, Ti3C2 MXene nanosheet-integrated cobalt-doped nickel hydroxide (NHCoMX) composite was synthesized via a hydrothermal method. The abundant pores in the Ti3C2 MXene nanosheet (MX)-integrated microarchitecture increased the number of active sites and facilitated charge transfer, thus enhancing electrocatalysis. Specifically, the MX-enhanced charge transfer considerably transformed the microelectronic structure of cobalt-doped Ni(OH)2(NHCo), which promoted its hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Hence, as an EWS catalyst, NHCoMX exhibited an exceptional electrocatalytic activity, demonstrating OER and HER overpotentials of 310 mV and 73 mV, respectively, with low Tafel slopes of 65 mV dec-1 and 85 mV dec-1, respectively; it exhibited a current density of 10 mV cm-2 in 1.0 mol L-1 KOH, representing the closest efficiency to the noble state-of-the-art RuO2 and Pt/C catalyst. Furthermore, the developed electrocatalyst improved the activities of both HER and OER, leading to an overall EWS current density of 10 mA cm-2 at 1.72 V in an alkaline electrolyte with two electrodes. This study describes an efficient heterostructured NHCoMX composite electrocatalyst. It is significantly comparable to the noble state-of-the-art electrocatalysts and can be extended to fabricate resourceful catalysts for large-scale EWS applications. (c) 2024 Institute of Process Engineering, Chinese Academy of Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | Manchuri, Amaranadha Reddy; Devarayapalli, Kamakshaiah Charyulu; Kim, Bolam; Lim, Youngsu; Lee, Dae Sung | Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea | Manchuri, Amaranadha Reddy/J-3982-2016 | 58343647900; 15069351300; 57208922438; 57207112603; 55568524907 | daesung@knu.ac.kr; | GREEN ENERGY & ENVIRONMENT | GREEN ENERGY ENVIRON | 2096-2797 | 2468-0257 | 10 | 4 | SCIE | CHEMISTRY, PHYSICAL;ENERGY & FUELS;ENGINEERING, CHEMICAL;GREEN & SUSTAINABLE SCIENCE & TECHNOLOGY | 2024 | 14.6 | 3.7 | 7.26 | 2025-05-07 | 6 | 5 | Cobalt-doped nickel hydroxide; Electrochemical water splitting; Oxygen evolution reaction; Hydrogen evolution reaction | STEP HYDROTHERMAL SYNTHESIS; QUANTUM DOTS; PHOTOCATALYTIC ACTIVITY; HYDROGEN EVOLUTION; THIN-FILM; OXYGEN; NANOPARTICLES; ELECTRODE; ENERGY; METAL | Cobalt-doped nickel hydroxide; Electrochemical water splitting; Hydrogen evolution reaction; Oxygen evolution reaction; Ti<sub>3</sub>C<sub>2</sub> MXene nanosheets | Cobalt; Cobalt alloys; Cobalt deposits; Electrolysis; Electrolytes; Hydrogen evolution reaction; Hydrothermal synthesis; Ionization of gases; Oxygen evolution reaction; Palladium; Photodissociation; Potassium hydroxide; Ruthenium alloys; Ruthenium compounds; Titanium dioxide; Cobalt-doped nickel hydroxide; Electrochemical water splitting; Electrochemicals; Evolution reactions; Hydrogen evolution reactions; Nickel hydroxides; Oxygen evolution; Ti3C2 mxene nanosheet; Water splitting; ]+ catalyst; Nanosheets | English | 2025 | 2025-04 | 10.1016/j.gee.2024.08.006 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Truth Default or Generalized Skepticism? The Role of Overconfidence in the Relationship Between Social Media News Use and Traditional Media Use | This article examines a model positing that overconfidence in political understanding resulting from social media use for news and politics hampers traditional media use. It confirms a positive relationship between Facebook political information experiences and overconfidence in political understanding. However, contrary to expectations, there is a positive relationship between overconfidence and traditional media use. An exploratory post hoc analysis, viewed through the lens of truth vs. false-default orientations, suggests overconfident users might use traditional news outlets to confirm their sense of knowledge, thereby exhibiting a false-default orientation on social media political information. | Kang, Taewoo; Thorson, Kjerstin; Pak, Chankyung | Michigan State Univ, Coll Commun Arts & Sci, 404 Wilson Rd, E Lansing, MI 48824 USA; Colorado State Univ, Coll Liberal Arts, Ft Collins, CO USA; Kyungpook Natl Univ, Dept Media & Commun, Daegu, South Korea | 58537100300; 16302616500; 57221594374 | kangtaew@msu.edu; | SOCIAL MEDIA + SOCIETY | SOC MEDIA SOC | 2056-3051 | 11 | 1 | SSCI | COMMUNICATION | 2024 | 4.9 | 3.7 | 0 | 2025-05-07 | 0 | 0 | social media; political knowledge; overconfidence; truth default; deception bias | POLITICAL KNOWLEDGE; COMMUNICATION; EXPOSURE; MODEL; APPROPRIATENESS; INFORMATION; ELECTION | deception bias; overconfidence; political knowledge; social media; truth default | English | 2025 | 2025-01 | 10.1177/20563051251315255 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Genomic-based animal management in the early- and late-finishing system of Hanwoo cattle | In the Korean cattle feedlot industry, profitability is largely dependent on the carcass value at slaughter, which is influenced by genetic and environmental factors, including finishing time and feeding strategies. This study evaluated the predictive potential of genomic information for four economic traits-carcass weight (CWT), eye muscle area (EMA), backfat thickness (BFT), and marbling score (MS)-and the final meat grades in 975 Hanwoo cattle. Animals were grouped according to slaughter timing (Early and Late Finishing), and the genomic estimated breeding values for each trait were calculated. The analysis confirmed that all traits, except for CWT, were unaffected by finishing time. However, CWT was found to be influenced by both environmental factors and paternal effects. Trends in the phenotypic values for CWT, EMA, and MS increased with higher selection indices, while BFT exhibited mixed patterns, which suggests environmental influences. A-grade proportions increased with higher indices, thereby demonstrating the potential of genomic data for the early selection of high-grade animals. These findings underscore the value of genomic information in Hanwoo cattle breeding strategies, although sample size expansion may improve prediction accuracy for certain grades. | Shin, J. W.; Chung, Y.; Maeng, S. Y.; Lee, S. H.; Choi, Y.; Hong, E.; Lee, J.; Cho, E.; Chung, K. Y.; Yoon, D.; Lee, J. H. | Chungnam Natl Univ, Dept Bio AI Convergence, Daejeon 34134, South Korea; Chungnam Natl Univ, Inst Agr Sci, Daejeon 34134, South Korea; Chungnam Natl Univ, Div Anim & Dairy Sci, Daejeon 34134, South Korea; Quant Res & Solut Co, Daejeon 34134, South Korea; Chungnam Natl Univ, Dept Biobig Data, Daejeon 34134, South Korea; Korea Natl Coll Agr & Fisheries, Dept Beef Sci, Jeonju 54874, South Korea; Kyungpook Natl Univ, Grad Sch, Dept Anim Sci & Biotechnol, Sangju 37224, South Korea; Chungnam Natl Univ, Dept Anim Sci, Daejeon 34134, South Korea | 59124518900; 57216463601; 59650789600; 59475424700; 59907880200; 59652304000; 27167898000; 57224364243; 23977406100; 7202875754; 54996473800; 59538710100 | slee46@cnu.ac.kr; | ANIMAL | ANIMAL | 1751-7311 | 1751-732X | 19 | 6 | SCIE | AGRICULTURE, DAIRY & ANIMAL SCIENCE;VETERINARY SCIENCES | 2024 | 4.2 | 3.8 | 0 | 2025-06-11 | 0 | 0 | Economic traits; Final grades; Finishing time; Genomic information; Korean cattle | GROWTH-PERFORMANCE; CARCASS CHARACTERISTICS; MEAT QUALITY; BEEF; COW; AGE | Economic traits; Final grades; Finishing time; Genomic information; Korean cattle | Animal Husbandry; Animals; Breeding; Cattle; Female; Genomics; Male; Meat; Phenotype; Republic of Korea; animal; animal husbandry; bovine; breeding; female; genetics; genomics; male; meat; phenotype; physiology; procedures; South Korea | English | 2025 | 2025-06 | 10.1016/j.animal.2025.101526 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis | Chondrocytes can shift their metabolism to oxidative phosphorylation (OxPhos) in the early stages of osteoarthritis (OA), but as the disease progresses, this metabolic adaptation becomes limited and eventually fails, leading to mitochondrial dysfunction and oxidative stress. Here we investigated whether enhancing OxPhos through the inhibition of pyruvate dehydrogenase kinase (PDK) 2 affects the metabolic flexibility of chondrocytes and cartilage degeneration in a surgical model of OA. Among the PDK isoforms, PDK2 expression was increased by IL-1 beta in vitro and in the articular cartilage of the DMM model in vivo, accompanied by an increase in phosphorylated PDH. Mice lacking PDK2 showed significant resistance to cartilage damage and reduced pain behaviors in the DMM model. PDK2 deficiency partially restored OxPhos in IL-1 beta-treated chondrocytes, leading to increases in APT and the NAD+/NADH ratio. These metabolic changes were accompanied by a decrease in reactive oxygen species and senescence in chondrocytes, as well as an increase in the expression of antioxidant proteins such as NRF2 and HO-1 after IL-1 beta treatment. At the signaling level, PDK2 deficiency reduced p38 signaling and maintained AMPK activation without affecting the JNK, mTOR, AKT and NF-kappa B pathways. p38 MAPK signaling was critically involved in reactive oxygen species production under glycolysis-dominant conditions in chondrocytes. Our study provides a proof of concept for PDK2-mediated metabolic reprogramming toward OxPhos as a new therapeutic strategy for OA. | Han, Jin; Kim, Yoon Hee; Han, Seungwoo | Kyungpook Natl Univ, Res Inst Aging & Metab, Lab Arthrit & Cartilage Biol, Daegu, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Rheumatol, Daegu, South Korea | 57218360938; 59548018900; 55246807000 | kiefe73@gmail.com; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 57 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 0 | 2025-05-07 | 0 | 0 | ACTIVATED PROTEIN-KINASE; MITOCHONDRIAL DYSFUNCTION; ARTICULAR-CARTILAGE; RESPIRATORY-CHAIN; SIGNALING PATHWAY; CHONDROCYTE; AMPK; OVERPRODUCTION; MECHANISMS; APOPTOSIS | Animals; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Interleukin-1beta; Male; Mice; Mice, Knockout; Osteoarthritis; Oxidative Phosphorylation; Oxidative Stress; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Reactive Oxygen Species; Signal Transduction; beta galactosidase; interleukin 1beta; pyruvate dehydrogenase kinase 2; interleukin 1beta; Pdk2 protein, mouse; pyruvate dehydrogenase kinase; reactive oxygen metabolite; AMPK signaling; animal cell; animal experiment; animal model; animal tissue; Article; articular cartilage; cartilage degeneration; chondrocyte; glycolysis; in vitro study; male; MAPK signaling; metabolic capacity; metabolic reprogramming; mouse; nonhuman; osteoarthritis; oxidative phosphorylation; oxidative stress; proof of concept; protein expression; pyruvate dehydrogenase complex deficiency; pyruvate dehydrogenase kinase 2 deficiency; scoring system; surgically induced osteoarthritis; animal; articular cartilage; chondrocyte; disease model; etiology; knockout mouse; metabolism; pathology; signal transduction | English | 2025 | 2025-02 | 10.1038/s12276-025-01400-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Phospholipase C β4 promotes RANKL-dependent osteoclastogenesis by interacting with MKK3 and p38 MAPK | Phospholipase C beta (PLC beta) is involved in diverse biological processes, including inflammatory responses and neurogenesis; however, its role in bone cell function is largely unknown. Among the PLC beta isoforms (beta 1-beta 4), we found that PLC beta 4 was the most highly upregulated during osteoclastogenesis. Here we used global knockout and osteoclast lineage-specific PLC beta 4 conditional knockout (LysM-PLC beta 4-/-) mice as subjects and demonstrated that PLC beta 4 is a crucial regulator of receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast differentiation. The deletion of PLC beta 4, both globally and in the osteoclast lineage, resulted in a significant reduction in osteoclast formation and the downregulation of osteoclast marker genes. Notably, male LysM-PLC beta 4-/- mice presented greater bone mass and fewer osteoclasts in vivo than their wild-type littermates, without altered osteoblast function. Mechanistically, we found that PLC beta 4 forms a complex with p38 mitogen-activated protein kinase (MAPK) and MAPK kinase 3 (MKK3) in response to RANKL-induced osteoclast differentiation, thereby modulating p38 activation. An immunofluorescence assay further confirmed the colocalization of PLC beta 4 with p38 after RANKL exposure. Moreover, p38 activation rescued impaired osteoclast formation and restored the reduction in p38 phosphorylation caused by PLC beta 4 deficiency. Thus, our findings reveal that PLC beta 4 controls osteoclastogenesis via the RANKL-dependent MKK3-p38 MAPK pathway and that PLC beta 4 may be a potential therapeutic candidate for bone diseases such as osteoporosis. | Lee, Dong-Kyo; Jin, Xian; Choi, Poo-Reum; Cui, Ying; Che, Xiangguo; Lee, Sihoon; Hur, Keun; Kim, Hyun-Ju; Choi, Je-Yong | Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu, South Korea; Gachon Univ, Dept Internal Med, Sch Med, Incheon, South Korea; Gachon Univ, Lab Mol Endocrinol, Sch Med, Incheon, South Korea | Choi, Je-Yong/AAR-7334-2021; Hur, Keun/G-9513-2011 | 57216603928; 57204810645; 58974835200; 58974396100; 54792660600; 7601394657; 59817404800; 57208650339; 7501391068 | biohjk@knu.ac.kr; jechoi@knu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 57 | 2 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 4.1 | 2025-05-07 | 1 | 2 | ACTIVATED PROTEIN-KINASE; KAPPA-B; REGULATES OSTEOCLASTOGENESIS; RECEPTOR ACTIVATOR; SIGNALING PATHWAY; DIFFERENTIATION; NFATC1; LIGAND; IDENTIFICATION; EXPRESSION | Animals; Cell Differentiation; Male; MAP Kinase Kinase 3; Mice; Mice, Knockout; Osteoclasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; Phospholipase C beta; Protein Binding; RANK Ligand; mitogen activated protein kinase 14; mitogen activated protein kinase kinase 3; osteoclast differentiation factor; phospholipase C beta4; Map2k3 protein, mouse; mitogen activated protein kinase kinase 3; mitogen activated protein kinase p38; osteoclast differentiation factor; phospholipase C beta; protein binding; animal cell; animal experiment; animal tissue; Article; bone cell function; bone histomorphometry; cell differentiation; cell function; cell proliferation assay; controlled study; down regulation; female; gene expression; histology; immunoblotting; immunofluorescence assay; immunoprecipitation; male; micro-computed tomography; morphometry; mouse; mRNA expression level; nervous system development; nonhuman; osteoclast; osteoclastogenesis; osteoporosis; real time polymerase chain reaction; animal; bone development; cell differentiation; genetics; knockout mouse; metabolism; osteoclast | English | 2025 | 2025-02 | 10.1038/s12276-025-01390-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Sediment accumulation at the Amazon coast observed by satellite gravimetry | Terrestrial sediment transport through large rivers exerts a significant impact on coastal morphology, marine ecosystems, and human livelihoods. Accurately measuring these sediment discharges has long been a challenge. Traditional in-situ methods fall short of providing comprehensive and continuous assessments of sediment dynamics due to spatiotemporal and economic constraints. While remote sensing techniques using satellite imagery have offered valuable insights into sediment transportation and deposition, their scope is primarily restricted to observing suspended sediment loads rather than total loads. Sediment accumulation at river margins will cause gravity increases observable by the Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow-On (GFO) missions. Previous efforts to observe sediment signals lacked proper corrections for various GRACE/GFO issues, including leakage of signals from surrounding land, variations in nearby ocean mass, and noise levels that typically exceed sediment signal magnitudes. In this study, we develop a new approach to obtain a satellite gravity estimate of sediment accumulation along the Amazon coast where the largest amount of sediment deposition is expected. We address limitations in previous studies using three steps: Forward modeling to suppress leakage of signal from land to oceans; adjusting ocean mass change via the sea level equation; and filtering using empirical orthogonal functions. The estimated accumulation rate of sediment on the Amazon continental shelf is approximately 1301 Mtons per year for the period June 2002 to May 2023. This estimate is slightly higher than the results from field-based studies, which fall in the range 550 to 1030 Mtons per year. | Oh, Earthu H.; Seo, Ki-Weon; Jeon, Taehwan; Eom, Jooyoung; Chen, Jianli; Wilson, Clark R. | Seoul Natl Univ, Dept Earth Sci Educ, Seoul, South Korea; Seoul Natl Univ, Ctr Educ Res, Seoul, South Korea; Kyungpook Natl Univ, Dept Earth Sci Educ, Daegu, South Korea; Hong Kong Polytech Univ, Dept Land Surveying & Geoinformat, Hong Kong, Peoples R China; Hong Kong Polytech Univ, Res Inst Land & Space, Hong Kong, Peoples R China; Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen, Peoples R China; Univ Texas Austin, Jackson Sch Geosci, Dept Earth & Planetary Sci, Austin, TX USA; Univ Texas Austin, Ctr Space Res, Austin, TX USA | Chen, Jianli/KUD-8259-2024; Seo, Ki-weon/AAH-7729-2021; Eom, Jooyoung/KBC-4439-2024 | 59662120700; 8407160800; 57193555379; 36645970800; 57205523218; 7404896041 | seokiweon@snu.ac.kr; | REMOTE SENSING OF ENVIRONMENT | REMOTE SENS ENVIRON | 0034-4257 | 1879-0704 | 321 | SCIE | ENVIRONMENTAL SCIENCES;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING | 2024 | 11.4 | 3.8 | 3.89 | 2025-05-07 | 1 | 1 | Satellite gravimetry; Coastal geodesy; Amazon River; Sediment transport | WATER DISCHARGE; RIVER SEDIMENT; TRANSPORT; OCEAN; DENUDATION; DYNAMICS; IMPACTS; GRACE; BASIN; EAST | Amazon River; Coastal geodesy; Satellite gravimetry; Sediment transport | Amazon River; Geodetic satellites; Gravimeters; River pollution; Sediment transport; Suspended sediments; Tropics; Amazon river; Coastal geodesy; Coastal morphology; Gravity recovery and climate experiments; Large rivers; Satellite gravimetries; Sediment accumulation; Sediment deposition; Sediment discharge; Terrestrial sediments; bioaccumulation; empirical analysis; environmental constraint; geodesy; GRACE; gravimetry; satellite imagery; sediment transport; spatiotemporal analysis; Orthogonal functions | English | 2025 | 2025-05-01 | 10.1016/j.rse.2025.114688 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | The guanine nucleotide exchange factor DOCK5 negatively regulates osteoblast differentiation and BMP2-induced bone regeneration via the MKK3/6 and p38 signaling pathways | DOCK5 (dedicator of cytokinesis 5), a guanine nucleotide exchange factor for Rac1, has been implicated in BMP2-mediated osteoblast differentiation, but its specific role in osteogenesis and bone regeneration remained unclear. This study investigated the effect of DOCK5 on bone regeneration using C21, a DOCK5 chemical inhibitor, and Dock5-deficient mice. Osteoblast differentiation and bone regeneration were analyzed using bone marrow mesenchymal stem cells (BMSCs) and various animal models. C21 significantly enhanced osteoblast differentiation and mineral deposition in mouse MC3T3-E1 cells and in human and mouse BMSCs. Dock5 knockout (KO) mice exhibited increased bone mass and mineral apposition rate, with their BMSCs showing enhanced osteoblast differentiation. Calvarial defect and ectopic bone formation models demonstrated significant induction of bone regeneration in Dock5 KO mice compared to wild-type (WT) mice. Moreover, DOCK5 inhibition by C21 in WT mice enhanced BMP2-induced subcutaneous ectopic bone formation. The mechanism responsible for enhanced bone formation induced by DOCK5 inhibition may involve the suppression of Rac1 under TAK1, accompanied by the activation of MKK3/6 and p38 induced by BMP2. These findings strongly suggest that DOCK5 negatively regulates osteoblast differentiation and bone regeneration through signaling pathways involving TAK1, MKK3/6, and p38, providing new insights into potential therapeutic strategies for bone regeneration. | Kim, Ju Ang; Im, Soomin; Lim, Jiwon; Hong, Jung Min; Ihn, Hye Jung; Bae, Jong-Sup; Kim, Jung-Eun; Bae, Yong Chul; Park, Eui Kyun | Kyungpook Natl Univ, Sch Dent, Dept Pathol & Regenerat Med, IHBR, Daegu 41940, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Anat & Neurobiol, Daegu 41940, South Korea | Kim, Ju Ang/LWI-0914-2024 | 55991948000; 59379780100; 13404844200; 57218328262; 56421724400; 16021543200; 57209054588; 56377838800; 37071072400 | epark@knu.ac.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 57 | 1 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 0 | 2025-05-07 | 1 | 1 | MORPHOGENETIC PROTEINS; FAMILY | Animals; Bone Morphogenetic Protein 2; Bone Regeneration; Cell Differentiation; Guanine Nucleotide Exchange Factors; Humans; MAP Kinase Kinase 3; MAP Kinase Kinase 6; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Knockout; Osteoblasts; Osteogenesis; p38 Mitogen-Activated Protein Kinases; rac1 GTP-Binding Protein; Signal Transduction; 4 amino 6 [2 [[4 (diethylamino) 1 methylbutyl]amino] 6 methyl 4 pyrimidinyl] 2 methylquinoline; agents affecting metabolism; beta actin; buloxibutid; calcein; guanine nucleotide exchange factor; guanine nucleotide exchange factor DOCK5; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; recombinant protein; rhBMP2; synaptophysin; transcription factor RUNX2; unclassified drug; bone morphogenetic protein 2; Dock5 protein, mouse; guanine nucleotide exchange factor; Map2k6 protein, mouse; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; mitogen activated protein kinase p38; Rac1 protein; animal cell; animal experiment; animal model; animal tissue; Article; bone defect; bone density; bone marrow mesenchymal stem cell; bone mass; bone regeneration; Bsp gene; Calvarial defect; cell differentiation; Col1a1 gene; controlled study; gene; gene deletion; gene expression; genetic transfection; human; human cell; immunohistochemistry; male; MC3T3-E1 cell line; mouse; nonhuman; osteoblast; Osx gene; protein expression; protein phosphorylation; Rac1 gene; reverse transcription polymerase chain reaction; signal transduction; TAK1 gene; Western blotting; animal; bone development; cytology; genetics; knockout mouse; MAPK signaling; mesenchymal stem cell; metabolism; signal transduction | English | 2025 | 2025-02 | 10.1038/s12276-024-01372-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | VGF and the VGF-derived peptide AQEE30 stimulate osteoblastic bone formation through the C3a receptor | New therapeutic targets, especially those that stimulate bone formation in cortical bone, are needed to overcome the limitations of current antiosteoporotic drugs. We previously demonstrated that factors secreted from megakaryocytes (MKs) promote bone formation. Here we conducted a proteomic analysis to identify a novel bone-forming factor from MK secretions. We revealed that Vgf, a nerve growth factor-responsive gene, and its derived active peptide AQEE30 in MK-conditioned medium play important roles in osteoblast proliferation and in vitro bone formation. In both Vgf-deficient male and female mice, the cortical bone mass was significantly decreased due to reductions in osteoblast number and bone formation activity. AQEE30 stimulated intracellular cyclic adenosine monophosphate (cAMP) levels and protein kinase A (PKA) activity in osteoblasts, whereas an adenylyl cyclase inhibitor blocked AQEE30-stimulated osteoblast proliferation and in vitro bone formation. Complement C3a receptor-1 (C3AR1) was expressed and interacted with AQEE30 in osteoblasts, and C3AR1 inhibition blocked all AQEE30-induced changes, including stimulated proliferation, bone formation and cAMP production, in osteoblasts. Injecting mini-PEGylated AQEE30 into calvaria increased the number of osteocalcin-positive cells and new bone formation. In conclusion, this study reveals a novel role of VGF in bone formation, particularly in cortical bone, and shows that AQEE30, a VGF-derived peptide, mediates this role by activating cAMP-PKA signaling via the C3AR1 receptor in osteoblasts. | Moon, Sung-Ah; Kim, Jin-Man; Lee, Young-Sun; Cho, Han Jin; Choi, Young Jin; Yoon, Jong Hyuk; Kim, Dayea; Che, Xiangguo; Jin, Xian; Baek, In-Jeoung; Lee, Seung Hun; Choi, Je-Young; Koh, Jung-Min | Univ Ulsan, Asan Med Ctr, Dept Med Sci, Coll Med,AMIST, Seoul, South Korea; Asan Med Ctr, Asan Inst Life Sci, Seoul, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Life Sci, Pohang, South Korea; Korea Brain Res Inst, Neurodegenerat Dis Res Grp, Daegu, South Korea; Daegu Gyeongbuk Med Innovat Fdn K Med Hub, New Drug Dev Ctr, Daegu, South Korea; Kyungpook Natl Univ, Korea Mouse Phenotyping Ctr, Cell & Matrix Res Inst, Sch Med,Dept Biochem & Cell Biol, Daegu, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Cell & Genet Engn, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Div Endocrinol & Metab, Seoul, South Korea | 57201480792; 57209199618; 57211154666; 57195607674; 57205885383; 59693248300; 54792023100; 54792660600; 57204810645; 8957055300; 57212403256; 59693988700; 7201756992 | jechoi@knu.ac.kr; jmkoh@amc.seoul.kr; | EXPERIMENTAL AND MOLECULAR MEDICINE | EXP MOL MED | 1226-3613 | 2092-6413 | 57 | 3 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;MEDICINE, RESEARCH & EXPERIMENTAL | 2024 | 12.9 | 3.8 | 0 | 2025-05-07 | 0 | 0 | SIGNALING PATHWAY; IN-VITRO; TLQP-21; CELLS; DIFFERENTIATION; OSTEOPOROSIS; ENHANCEMENT; PREVENTS; SURVIVAL; OBESITY | Animals; Cell Proliferation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Female; Male; Mice; Nerve Growth Factors; Neuropeptides; Osteoblasts; Osteogenesis; 9 (tetrahydro 2 furyl)adenine; adenylate cyclase inhibitor; adenylate cyclase inhibitor aqee30; alkaline phosphatase; alpha tubulin; complement component C3 receptor; complement component C3a; complement component C3a receptor; cyclic AMP; cyclic AMP dependent protein kinase; cyclin dependent kinase; hepatoma derived growth factor; high mobility group B1 protein; nerve growth factor; osteocalcin; protein p21; small interfering RNA; thrombopoietin; unclassified drug; cyclic AMP; cyclic AMP dependent protein kinase; nerve growth factor; neuropeptide; VGF peptide; animal cell; animal cell culture; animal experiment; animal model; animal tissue; Article; bone defect; bone density; bone development; bone metabolism; bone mineralization; bone surface density; bone volume fraction; BrdU assay; calvaria; cAMP signaling; cell cycle distribution; cell cycle parameters; cell differentiation; cell proliferation; cell viability; cell viability assay; controlled study; cortical bone; cortical thickness (bone); enzyme activity; enzyme linked immunosorbent assay; female; gene knockout; high performance liquid chromatography; human; human cell; immunohistochemistry; K-562 cell line; liquid chromatography-mass spectrometry; male; MC3T3-E1 cell line; megakaryocyte; micro-computed tomography; morphometry; mouse; nonhuman; ossification; osteoblast; osteoclast; osteolysis; osteopenia; PEGylation; protein expression; protein phosphorylation; proteomics; pull-down assay; real time polymerase chain reaction; size exclusion chromatography; upregulation; Western blotting; animal; cell proliferation; cytology; drug effect; metabolism | English | 2025 | 2025-03 | 10.1038/s12276-025-01419-y | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | Erratum | Correction to: Monitoring the formation of infinite-layer transition metal oxides through in situ atomic-resolution electron microscopy (Nature Chemistry, (2025), 17, 1, (66-73), 10.1038/s41557-024-01617-7) | Correction to: Nature Chemistryhttps://doi.org/10.1038/s41557-024-01617-7, published online 27 August 2024. This paper was originally published under standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature Limited). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the online version of the article. © The Author(s) 2025. | Xing, Yaolong; Kim, Inhwan; Kang, Kyeong Tae; Byun, Jinho; Choi, Woo Seok; Lee, Jaekwang; Oh, Sang Ho | Department of Energy Engineering, Korea Institute of Energy Technology, Naju, South Korea, Institute for Energy Materials and Devices, Korea Institute of Energy Technology, Naju, South Korea; Department of Physics, Pusan National University, Busan, South Korea; Department of Physics, Sungkyunkwan University, Suwon, South Korea, Department of Physics, KNU G-LAMP Research Center, Kyungpook National University, Daegu, South Korea; Department of Energy Engineering, Korea Institute of Energy Technology, Naju, South Korea, Institute for Energy Materials and Devices, Korea Institute of Energy Technology, Naju, South Korea; Department of Physics, Sungkyunkwan University, Suwon, South Korea; Department of Physics, Pusan National University, Busan, South Korea; Department of Energy Engineering, Korea Institute of Energy Technology, Naju, South Korea, Institute for Energy Materials and Devices, Korea Institute of Energy Technology, Naju, South Korea | 57220044509; 57226310158; 56002123900; 57195412299; 14031133800; 55888626200; 55702556500 | shoh@kentech.ac.kr; jaekwangl@pusan.ac.kr; choiws@skku.edu; | Nature Chemistry | NAT CHEM | 1755-4330 | 1755-4349 | 17 | 5 | SCIE | CHEMISTRY, MULTIDISCIPLINARY | 2024 | 20.2 | 4.0 | 0 | 2025-05-07 | 0 | controlled study; drug therapy; erratum | English | Final | 2025 | 10.1038/s41557-025-01816-w | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Microbial Melatonin Production Improves Plant Metabolic Function in Short-Term Climate-Induced Stresses | Climate change, specifically high temperatures, can reduce soil moisture and cause hypersaline conditions, which creates an unsustainable agro-production system. Microbial symbionts associated with plants relinquish stressful conditions by producing stress-protecting substances. Melatonin is a signaling and stress-protecting molecule for plants, but is least known for microbial symbionts and their function in stress protection. Here, our study shows that the melatonin-synthesizing Bacillus velezensis EH151 (27.9 ng/mL at 96 h) significantly improved host plant (Glycine max L.) growth, biomass, photosynthesis, and reduced oxidative stress during heat and salinity stress conditions than the non-inculcated control. The EH151 symbiosis enhanced the macronutrient (P, Ca, and K) and reduced Na uptake in shoots during stress conditions. The microbial inoculation significantly expressed the high-affinity K+ transporter, MYB transcription factor, Salt Overly Sensitive 1, Na+/H+ antiporter 2, and heat shock transcription factors in spatio-temporal orders during heat and salinity stress (H&S 1, 3, 10, and 14 h). We observed that microbial strain significantly increased the plant's endogenous abscisic acid (49.5% in H&S 10 h), jasmonic acid (71% in H&S 10 h), and melatonin biosynthesis (418% in H&S 14 h). Metabolome map of plant defense response showed that EH151 enhanced activation of amino acid metabolism pathways (e.g., glutamate (34%) L-aspartate (82%), glycine (18.5%), and serine (58%) under H&S 14 h compared to non-inoculation). Conversely, the free sugars and organic acids within the central carbon metabolism were significantly activated in non-inoculated combined heat and salinity stress compared to inoculated plants-suggesting lesser defense energy activated for stress tolerance. In conclusion, the current results show promising effects of the microbial abilities of melatonin that can regulate host growth and defense responses. Utilization of beneficial strains like B. velezensis EH151 could be the ideal strategy to improve stress tolerance and overcome the adverse impact of climate-induced abrupt changes. | Kwon, Eun-Hae; Adhikari, Arjun; Khan, Abdul Latif; Do, Eunsu; Methela, Nusrat Jahan; Lee, Chung-Yeol; Kang, Sang-Mo; Ku, Kang-Mo; Yun, Byung-Wook; Lee, In-Jung | Kyungpook Natl Univ, Dept Appl Biosci, Daegu, South Korea; Univ Houston, Cullen Coll Engn, Dept Engn Technol, Houston, TX USA; Korea Univ, Coll Life Sci & Biotechnol, Dept Plant Biotechnol, Seoul, South Korea; Noakhali Sci & Technol Univ, Dept Agr, Noakhali, Bangladesh; Kyungpook Natl Univ, Dept Stat Grad Sch, Daegu, South Korea | Adhikari, Arjun/AAV-6297-2021; Ku, Kang-Mo/JPL-8941-2023; Kang, Sang-Mo/MBG-7823-2025; Lee, In-Jung/GLS-0432-2022; Khan, Sher/H-2958-2012 | 57224398710; 57195601415; 26639372800; 58880756100; 57880065700; 58076774700; 56189696900; 59899822700; 8245123600; 16425830900 | ijlee@knu.ac.kr; | JOURNAL OF PINEAL RESEARCH | J PINEAL RES | 0742-3098 | 1600-079X | 77 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM;NEUROSCIENCES;PHYSIOLOGY | 2024 | 6.3 | 4.0 | 0 | 2025-06-11 | 0 | 0 | abiotic stresses; Bacillus velezensis; heat stress; ICP-MS; melatonin; melatonin producing microbes; metabolites; metabolomics; PGPB; salt stress | FREE AMINO-ACIDS; GLYCINE BETAINE; HEAT-STRESS; SALT; TEMPERATURE; ADAPTATION; TOLERANCE; GLUTAMATE; SYSTEMS | abiotic stresses; Bacillus velezensis; heat stress; ICP-MS; melatonin; melatonin producing microbes; metabolites; metabolomics; PGPB; salt stress | Bacillus; Climate Change; Glycine max; Melatonin; Stress, Physiological; abscisic acid; aspartic acid; calcium; carbohydrate; carbon; carboxylic acid; glutamic acid; glycine; heat shock transcription factor; jasmonic acid; melatonin; phosphorus; potassium; protein Myb; serine; amino acid metabolism; Article; biosynthesis; carbon metabolism; climate; controlled study; heat stress; nonhuman; physiological stress; plant growth; plant metabolism; plant stress; salt stress; soybean; Bacillus; climate change; metabolism; microbiology; physiological stress; soybean | English | 2025 | 2025-04 | 10.1111/jpi.70052 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
페이지 이동: