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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ Article ⓘ Long-term functional outcomes among patients surviving aneurysmal subarachnoid hemorrhage: The KOSCO study ⓘ Background and objectives: Aneurysmal subarachnoid hemorrhage (aSAH) remains a significant global health concern, and therefore, understanding their functional outcomes is essential. The aim of this study was to investigate the 1-year functional outcomes of patients with aSAH. Methods: We retrospectively analyzed data of patients with aSAH from the Korean Stroke Cohort for Functioning and Rehabilitation study, up to 1 year post-onset. The cohort data were collected twice. The first data was collected from August 2012 through May 2015, and the second data was collected from January to December in 2020, from nine different hospitals. Assessments were performed from 7 days to 1 year. Disability, measured by modified Rankin Scale (mRS), was analyzed in terms of good outcome (mRS 0 or 1) and mortality. In addition, functional level was further assessed using Functional Independence Measure (FIM) in aSAH survivors at 1 year post-onset. A subgroup analysis was conducted, with participants further classified into two groups: one with mild-to-moderate disability (mRS 0–3) and another with severe disability (mRS 4 or 5), as reported 7 days after onset. Multiple imputation method was used to handle missing data. In addition, mixed-effects model was used to analyze the trajectory of FIM. Results: A total of 517 patients with aSAH were included. Of these, 246 (47.6%) showed mild-to-moderate disability and 271 (52.4%) showed severe disability at 7 days. At 1 year after onset, the mortality rate was 6.0% and the good outcome was reported in 76.2% of patients. In aSAH survivors at 1 year, FIM showed a significant improvement over time, with a significant difference demonstrated between the subgroups. Age, initial clinical severity, and cognitive function at 7 days were also identified as significant covariates. Conclusions: The majority of patients reporting mild-to-moderate disability at 7 days exhibited good functional outcome, and even among those with severe disability, there was a favorable outcome with continuous improvement in their functional levels. Therefore, proper assessments and effective management should be employed to achieve favorable functional outcomes among aSAH survivors. © 2025 World Stroke Organization. ⓘ Lee, Ho Seok; Sohn, Min Kyun; Lee, Jongmin; Kim, Deog Young; Shin, Yong-Il; Oh, Gyung-Jae; Lee, Yang-Soo; Joo, Min Cheol; Lee, So Young; Song, Min-Keun; Han, Junhee; Ahn, Jeonghoon; Lee, Young-Hoon; Kim, Dae Hyun; Kim, Young-Taek; Kim, Yun-Hee; Chang, Won Hyuk ⓘ Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Rehabilitation Medicine, College of Medicine, Chungnam National University, Daejeon, South Korea; Department of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul, South Korea; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, South Korea; Department of Rehabilitation Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea; Department of Preventive Medicine, Wonkwang University School of Medicine, Iksan, South Korea; Department of Rehabilitation Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea; Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan, South Korea; Department of Rehabilitation Medicine, Jeju National University Hospital, Jeju National University School of Medicine, Jeju City, South Korea; Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School, Gwangju, South Korea; Department of Statistics, Hallym University, Chuncheon, South Korea; Department of Health Convergence, Ewha Womans University, Seoul, South Korea; Department of Preventive Medicine, Wonkwang University School of Medicine, Iksan, South Korea; Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Preventive Medicine, Chungnam National University Hospital, Daejeon, South Korea; Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Suwon-si, South Korea; Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, Department of Health Science and Technology, Department of Medical Device Management and Research, SAIHST, Sungkyunkwan University, Seoul, South Korea ⓘ ⓘ 57222648792; 7101840459; 57202882113; 55375583000; 55890990500; 7007056685; 57202952463; 56982599700; 57202327370; 55375416600; 57192890252; 8855402200; 55716155400; 57206099341; 57211411051; 57020121600; 35301717900 ⓘ wh.chang@samsung.com; ⓘ International Journal of Stroke ⓘ INT J STROKE ⓘ 1747-4930 1747-4949 SCIE CLINICAL NEUROLOGY;PERIPHERAL VASCULAR DISEASE ⓘ 2024 8.7 3.3 0 2025-05-07 ⓘ 0 ⓘ ⓘ functional outcome; longitudinal trajectory; Subarachnoid hemorrhage ⓘ ⓘ English Article in press 2025 10.1177/17474930251320566 ⓘ 바로가기 바로가기 바로가기
○ Article ⓘ Near-infrared-activatable angiogenic proteinaceous nanomicelles for sequential augmentation of bone repair in periodontal defects ⓘ The highly vascularized architecture of natural bone has inspired sequential augmentation of vascularization and osteogenesis to promote bone tissue regeneration, particularly in periodontal defects characterized by severely diminished bone quantity and quality, often worsened by systemic conditions such as osteoporosis. However, current growth factor delivery systems frequently lack precise control over release profiles and allow limited modification of predetermined kinetics. Herein, near-infrared (NIR) light-activatable angiogenic proteinaceous nanomicelles (NMs) bioengineered from vascular elastin-like polypeptide (VELP) have been proposed to enable rapid angiogenesis and on-demand release of osteoinductive growth factors in a biocompatible, minimally invasive manner. This on-demand release is triggered using a specific NIR stimulation (808 nm, 1.5 W/cm² for 10 min), resulting in approximately 80 % BMP-2 release within 5 h, which can be precisely timed to the optimal healing phase. The potential of bone morphogenetic protein-2 (BMP-2)-loaded VELP NMs to release BMP-2 upon NIR irradiation was validated, demonstrating enhanced osteogenic differentiation and maturation within a three-dimensional microporous scaffold. The findings establish VELP NMs as effective smart nanocarriers for growth factor delivery to support vascularized tissue regeneration. This NIR-activatable delivery system offers a promising strategy for the remotely controlled release of therapeutic cargo in tissue injuries. © 2025 Elsevier Inc. ⓘ Kim, Mou Seung; Kim, Dong Chang; Jo, Yun Kee ⓘ Department of Biomedical Convergence Science and Technology, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, 41566, South Korea; Department of Biomedical Convergence Science and Technology, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, 41566, South Korea; Department of Biomedical Convergence Science and Technology, Advanced Institute of Science and Technology, Kyungpook National University, Daegu, 41566, South Korea, Department of Advanced Bioconvergence, Kyungpook National University, Daegu, 41566, South Korea, Cell and Matrix Research Institute, Kyungpook National University, Daegu, 41944, South Korea ⓘ ⓘ 57298073800; 59938005800; 56123757800 ⓘ ykjo@knu.ac.kr; ⓘ Dental Materials ⓘ DENT MATER ⓘ 0109-5641 1879-0097 41 8 SCIE DENTISTRY, ORAL SURGERY & MEDICINE;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 6.3 3.4 N/A ⓘ 0 ⓘ ⓘ BMP-2 controlled release; Elastin-like polypeptide; NIR-activatable nanomicelles; On-demand growth factor delivery; Vascularized bone regeneration ⓘ Elastin; Fiber bonding; Glycoproteins; Bone morphogenetic protein-2; Bone morphogenetic protein-2 controled release; Bone regeneration; Controlled release; Demand growth; Elastin-like polypeptides; Growth factor delivery; Nanomicelles; Near Infrared; Near-infrared; Near-infrared-activatable nanomicelle; On demands; On-demand growth factor delivery; Vascularized bone regeneration; Tissue regeneration ⓘ English Final 2025 10.1016/j.dental.2025.06.003 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Associations of polygenic risk score, environmental factors, and their interactions with the risk of schizophrenia spectrum disorders ⓘ Background Emerging evidence indicates that gene-environment interactions (GEIs) are important underlying mechanisms for the development of schizophrenia (SZ). We investigated the associations of polygenic risk score for SZ (PRS-SZ), environmental measures, and their interactions with case-control status and clinical phenotypes among patients with schizophrenia spectrum disorders (SSDs).Methods The PRS-SZ for 717 SSD patients and 356 healthy controls (HCs) were calculated using the LDpred model. The Korea-Polyenvironmental Risk Score-I (K-PERS-I) and Early Trauma Inventory-Self Report (ETI-SR) were utilized as environmental measures. Logistic and linear regression analyses were performed to identify the associations of PRS-SZ and two environmental measures with case-control status and clinical phenotypes.Results The PRS-SZ explained 8.7% of SZ risk. We found greater associations of PRS-SZ and total scores of the K-PERS-I with case-control status compared to the ETI-SR total score. A significant additive interaction was found between PRS-SZ and K-PERS-I. With the subdomains of the K-PERS-I and ETI-SR, we identified significant multiplicative or additive interactions of PRS-SZ and parental socioeconomic status (pSES), childhood adversity, and recent life events in association with case-control status. For clinical phenotypes, significant interactions were observed between PRS-SZ and the ETI-SR total score for negative-self and between PRS-SZ and obstetric complications within the K-PERS-I for negative-others.Conclusions Our findings suggest that the use of aggregate scores for genetic and environmental measures, PRS-SZ and K-PERS-I, can more accurately predict case-control status, and specific environmental measures may be more suitable for the exploration of GEIs. ⓘ Rami, Fatima Zahra; Seo, Hyungwoo; Kang, Chaeyeong; Park, Seunghwan; Li, Ling; Le, Thi-Hung; Kim, Sung-Wan; Won, Seung-Hee; Chung, Wonil; Chung, Young-Chul ⓘ Jeonbuk Natl Univ, Jeonbuk Natl Univ Hosp, Res Inst Clin Med, Jeonju, South Korea; Jeonbuk Natl Univ Hosp, Biomed Res Inst, Jeonju, South Korea; Soongsil Univ, Dept Stat & Actuarial Sci, Seoul, South Korea; Jeonbuk Natl Univ, Med Sch, Dept Psychiat, Jeonju, South Korea; Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju, South Korea; Kyungpook Natl Univ, Sch Med, Dept Psychiat, Daegu, South Korea; Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA 02115 USA ⓘ Chung, Young/AAB-8242-2022; Rami, Fatima/ABS-5222-2022; Chung, Wonil/MXK-7601-2025 ⓘ 57231663300; 59739883400; 58037684600; 58839100000; 57232581000; 57695916500; 47962371200; 35278955600; 56107666000; 55712695800 ⓘ wchung@ssu.ac.kr; chungyc@jbnu.ac.kr; ⓘ PSYCHOLOGICAL MEDICINE ⓘ PSYCHOL MED ⓘ 0033-2917 1469-8978 55 SSCI;SCIE PSYCHOLOGY, CLINICAL;PSYCHOLOGY;PSYCHIATRY ⓘ 2024 5.5 3.5 0 2025-05-07 ⓘ 0 0 gene-environment interactions; Korea-Polyenvironmental Risk Score; polygenic risk score; Schizophrenia spectrum disorders ⓘ PSYCHOMETRIC PROPERTIES; PSYCHIATRIC-DISORDERS; CHILDHOOD ADVERSITY; GENETIC LIABILITY; CANNABIS USE; PSYCHOSIS; MODERATION; DEPRESSION; ETIOLOGY ⓘ gene-environment interactions; Korea-Polyenvironmental Risk Score; polygenic risk score; Schizophrenia spectrum disorders ⓘ Adult; Case-Control Studies; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genetic Risk Score; Humans; Male; Middle Aged; Multifactorial Inheritance; Phenotype; Republic of Korea; Risk Factors; Schizophrenia; adult; case control study; epidemiology; etiology; female; genetic predisposition; genetic risk score; genetics; genotype environment interaction; human; male; middle aged; multifactorial inheritance; phenotype; risk factor; schizophrenia; South Korea ⓘ English 2025 2025-04-11 10.1017/s0033291725000753 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ DASK-Net: A Lightweight Dual-Attention Selective Kernel Network for Efficient Dense Prediction in Remote Sensing Imagery ⓘ The precise and efficient extraction of buildings and road networks from aerial imagery is crucial for remote sensing applications, such as map building, urban development, and autonomous driving guidance systems. However, accurately extracting buildings and roads from remote sensing imagery is challenging due to varying resolutions, object scale variation, and diverse appearances of buildings and roads. While sophisticated models achieve high accuracy, their computational demands limit practical use on resource-constrained devices. Conversely, mainstream lightweight models often fail to generate high-quality segmentation maps for remote sensing data. To address these challenges, we introduce a dual-attention selective kernel network (DASK-Net), a novel lightweight architecture for efficient pixel-wise dense prediction. DASK-Net's core features a dual-attention selective kernel (DASK) module that integrates multiscale feature extraction with adaptive receptive fields and dual-attention mechanisms. This design captures diverse scales and orientations of features while focusing on salient input aspects. We conducted experiments on the Massachusetts roads, DeepGlobe, and WHU building datasets, comparing DASK-Net with numerous methods. The results demonstrate that DASK-Net outperforms these networks while significantly reducing computational complexity. With only 0.48M parameters, DASK-Net achieves an 89.54% intersection over union (IoU) and a 94.48% F1 score on the WHU building dataset, setting new performance standards for lightweight methods. ⓘ Sultonov, Furkat; Yun, Sangseok; Kang, Jae-Mo ⓘ Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Informat & Commun Engn, Busan 48513, South Korea ⓘ SULTONOV, FURKAT/NFS-3340-2025 ⓘ 57455045300; 56115729600; 56024930400 ⓘ furkatsultonov@knu.ac.kr; ssyun@pknu.ac.kr; jmkang@knu.ac.kr; ⓘ IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING ⓘ IEEE T GEOSCI REMOTE ⓘ 0196-2892 1558-0644 63 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING ⓘ 2024 8.6 3.5 N/A ⓘ 2 1 Feature extraction; Buildings; Roads; Remote sensing; Attention mechanisms; Kernel; Computer architecture; Computational modeling; Architecture; Building footprint extraction; channel attention; remote sensing imagery; road extraction; selective kernel (SK) networks; semantic segmentation; spatial attention; spatial attention ⓘ EXTRACTION; FUSION ⓘ Building footprint extraction; channel attention; remote sensing imagery; road extraction; selective kernel (SK) networks; semantic segmentation; spatial attention ⓘ Massachusetts; United States; Urban planning; Aerial imagery; Building footprint; Building footprint extraction; Channel attention; Remote sensing imagery; Road extraction; Road network; Selective kernel network; Semantic segmentation; Spatial attention; airborne sensing; architectural design; data set; pixel; remote sensing; semantic standardization; Image segmentation ⓘ English 2025 2025 10.1109/tgrs.2025.3566097 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Correction ⓘ DASK-Net: A Lightweight Dual-Attention Selective Kernel Network for Efficient Dense Prediction in Remote Sensing Imagery (vol 63, 5623416, 2025) ⓘ Presents corrections to the paper, (Corrections to "DASK-Net: A Lightweight Dual-Attention Selective Kernel Network for Efficient Dense Prediction in Remote Sensing Imagery"). ⓘ Sultonov, Furkat; Yun, Sangseok; Kang, Jae-Mo ⓘ Kyungpook Natl Univ, Dept Artificial Intelligence, Daegu 41566, South Korea; Pukyong Natl Univ, Dept Informat & Commun Engn, Busan 48513, South Korea ⓘ SULTONOV, FURKAT/NFS-3340-2025 ⓘ ⓘ furkatsultonov@knu.ac.kr; ssyun@pknu.ac.kr; jmkang@knu.ac.kr; ⓘ IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING ⓘ IEEE T GEOSCI REMOTE ⓘ 0196-2892 1558-0644 63 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING ⓘ 2024 8.6 3.5 ⓘ 0 Kernel; Remote sensing ⓘ ⓘ ⓘ ⓘ English 2025 2025 10.1109/tgrs.2025.3576881 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Lagrangian Characteristics of Machine Learning-Based Drop Size Distributions in Convective Cells: A Case Study ⓘ Understanding the variability of raindrop size distributions (DSDs) and their evolution is crucial for unraveling the microphysical processes within convective storms. This study utilized X-band polarimetric radar and a machine learning-based DSDs retrieval algorithm to investigate the spatiotemporal evolution of DSDs within convective cells. A well-developed typical convective cell was intensively observed using a unique scanning strategy, where range-height indicator (RHI) scan directions were adaptively adjusted in real-time and provided detailed observations of the cell lifecycle from initiation to dissipation. The retrieved DSD parameters demonstrated that the developing stage was characterized by active condensational growth, the mature stage by a dominant collision-coalescence process, and the dissipating stage by a similar DSDs pattern with the mature stage, but with a smaller mean diameter, weakened collision-coalescence process, and the potential evaporation. These findings highlight the potential of dual-polarimetric radar and machine learning-based retrieval techniques in providing deeper insights into the spatial and temporal structures of DSDs. ⓘ Shin, Kyuhee; Lee, GyuWon ⓘ Kyungpook Natl Univ, Ctr Atmospher REmote Sensing CARE, Dept Atmospher Sci, Weather Extremes Educ & Res Team BK21, Daegu 41566, South Korea ⓘ ; Shin, Kyuhee/LMO-2829-2024 ⓘ 57222003871; 7404852271 ⓘ kyuhee@knu.ac.kr; gyuwon@knu.ac.kr; ⓘ IEEE TRANSACTIONS ON GEOSCIENCE AND REMOTE SENSING ⓘ IEEE T GEOSCI REMOTE ⓘ 0196-2892 1558-0644 63 SCIE ENGINEERING, ELECTRICAL & ELECTRONIC;GEOCHEMISTRY & GEOPHYSICS;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;REMOTE SENSING ⓘ 2024 8.6 3.5 N/A ⓘ 0 0 Convective cell; drop size distribution; dual-polarimetric radar; dual-polarimetric radar; Lagrangian; Lagrangian; machine learning; machine learning; random forest (RF); random forest (RF); remote sensing; remote sensing; remote sensing ⓘ POLARIMETRIC RADAR; X-BAND; DIFFERENTIAL REFLECTIVITY; RAIN ATTENUATION; MICROPHYSICAL CHARACTERISTICS; DISTRIBUTION PARAMETERS; DISDROMETER; PRECIPITATION; VARIABILITY; RETRIEVAL ⓘ Convective cell; drop size distribution; dual-polarimetric radar; Lagrangian; machine learning; random forest (RF); remote sensing ⓘ Case-studies; Convective cell; Drop size distribution; Dual-polarimetric radar; Lagrangian; Machine-learning; Polarimetric radars; Raindrop size distribution; Random forests; Remote-sensing; algorithm; cell; evaporation; machine learning; radar; raindrop; remote sensing; Cell culture ⓘ English 2025 2025 10.1109/tgrs.2025.3576664 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Letter ⓘ SYNCRIP promotes cell cycle progression and lung tumorigenesis by modulating AURKB translation ⓘ ⓘ Kim, Hyeon Ji; Ryu, Hye Guk; Kang, Mingyu; Lee, Namgyu; Kim, Hyo-Jin; Lee, Dahye; Chung, Chaeuk; Kim, Sangjune; Lee, Kyung-Ha; Kim, Wanil; Byun, Jin-Seok; Kim, Kyong-Tai; Kim, Do-Yeon ⓘ Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Pohang Univ Sci & Technol POSTECH, Dept Life Sci, Pohang, South Korea; Natl Canc Ctr, Res Inst, Div Canc Biol, Goyang, South Korea; Dankook Univ, Dept Biomed Sci & Syst Biol, Cheonan, South Korea; ProGen Co Ltd, Seoul, South Korea; Chungnam Natl Univ, Coll Med, Dept Internal Med, Div Pulmonol & Crit Care Med, Daejeon, South Korea; Chungbuk Natl Univ, Dept Biol Sci & Biotechnol, Cheongju, South Korea; Pusan Natl Univ, Dept Mol Biol, Busan, South Korea; Gyeongsang Natl Univ, Dept Convergence Med Sci, Sch Med, Dept Biochem,Inst Med Sci, Jinju, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu, South Korea; Handong Global Univ, Generat Genom Res Ctr, Global Green Res & Dev Ctr, Pohang 37554, South Korea ⓘ Kim, Do-Yeon/AET-3021-2022 ⓘ 57216816929; 56611282900; 57815724500; 55330470700; 57206210723; 55277953000; 14522036600; 49661739600; 54967786000; 7405813437; 55430621800; 7409315595; 57203012542 ⓘ dykim82@knu.ac.kr; ktk@handong.edu; ⓘ CANCER COMMUNICATIONS ⓘ CANCER COMMUN ⓘ 2523-3548 45 2 SCIE ONCOLOGY ⓘ 2024 24.9 3.5 0 2025-05-07 ⓘ 1 0 ⓘ HNRNP Q ⓘ ⓘ aurora B kinase; cycloheximide; sirolimus; synaptotagmin; synaptotagmin binding cytoplasmic RNA interacting protein; unclassified drug; 5' untranslated region; affinity purification; animal cell; animal tissue; cell cycle progression; colony formation; CRISPR-CAS9 system; G2 phase cell cycle checkpoint; immunofluorescence assay; Letter; luciferase assay; lung tumor; NIH 3T3 cell line; nonhuman; protein expression; protein processing; RNA affinity purification; RNA pull-down; RNA sequence; tissue microarray; Western blotting; article; controlled study; human ⓘ English 2025 2025-02 10.1002/cac2.12634 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Engineered extracellular vesicles with surface FGF21 and enclosed miR-223 for treating metabolic dysfunction-associated steatohepatitis ⓘ Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disorder with a complex pathogenesis that requires combination therapies rather than monotherapies. Extracellular vesicles (EVs) exhibit inherently efficient delivery to the liver and can be engineered to carry various therapeutic substances, making them promising agents. In this study, EVs were engineered to display fibroblast growth factor 21 (FGF21) on their surface and encapsulate miR-223 (223/F-EVs), aiming to improve steatosis and alleviate inflammation and fibrosis, respectively. Introducing the 223/F-EVs into human liver cell lines significantly reduced both basal and induced levels of lipid storage, inflammation, and fibrosis markers. Furthermore, using an FGF21-blocking antibody or miR-223 inhibitor effectively diminished the efficacy of the 223/F-EVs, confirming the essential roles of FGF21 and miR-223 in these processes. In a Choline-Deficient, L-Amino acid-defined, High-Fat Diet (CDAHFD)-fed mouse model, intravenously administered 223/F-EVs demonstrated liver-preferential delivery and a marked reduction in the MASH phenotype without compromising bone density, unlike conventional FGF21 treatment. Collectively, 223/F-EVs convey FGF21 and miR-223 exclusively to the liver, offering strategic advantages by mitigating MASH progression via multiple pathways. This study lays a solid foundation for further investigation of engineered EVs as a transformative therapeutic approach for treating MASH. ⓘ Cho, Hanchae; Ju, Hyunji; Ahn, Yongdeok; Jang, Juhee; Cho, Juhyeong; Park, Eunju; Kang, Sung-Min; Lee, Jaemin; Seo, Daeha; Baek, Moon-Chang; Yea, Kyungmoo ⓘ Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, CMRI, Daegu 41944, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept Phys & Chem, Daegu 42988, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept New Biol, Daegu 42988, South Korea; Daegu Gyeongbuk Inst Sci & Technol, New Biol Res Ctr, Daegu 42988, South Korea ⓘ ⓘ 57184674000; 58306878500; 57870240100; 57970027500; 59702614400; 58168390300; 59499667300; 59930958400; 15133161500; 7006013097; 12769131100 ⓘ mcbaek@knu.ac.kr; ykm31@dgist.ac.kr; ⓘ BIOMATERIALS ⓘ BIOMATERIALS ⓘ 0142-9612 1878-5905 321 SCIE ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 12.9 3.6 0 2025-05-07 ⓘ 0 0 Metabolic dysfunction-associated steatohepatitis; Extracellular vesicles; Combination therapies; Fibroblast growth factor 21; Micro-RNA ⓘ LIVER; MECHANISM; EXOSOMES; FIBROSIS; DELIVERY; LINKERS; THERAPY; BETA ⓘ Combination therapies; Extracellular vesicles; Fibroblast growth factor 21; Metabolic dysfunction-associated steatohepatitis; Micro-RNA ⓘ Animals; Cell Line; Diet, High-Fat; Extracellular Vesicles; Fatty Liver; Fibroblast Growth Factors; Humans; Liver; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Cell culture; Pathology; alpha actin; alpha smooth muscle actin; beta actin; CD11b antigen; collagen type 1; collagen type 3; CXCL2 chemokine; fibroblast growth factor 21; fibroblast growth factor 21 engineered extracellular vesicle enclosed microRNA 223; gamma interferon inducible protein 10; lentivirus vector; liver protective agent; messenger RNA; microRNA 223; monocyte chemotactic protein 1; transforming growth factor beta1; triacylglycerol; unclassified drug; fibroblast growth factor; fibroblast growth factor 21; microRNA; MIRN223 microRNA, human; Combination therapy; Extracellular; Extracellular vesicle; Fibroblast growth factor; Fibroblast growth factor 21; Human liver cells; Liver disorder; Metabolic dysfunction-associated steatohepatitis; Micro-RNA; Mono-therapy; animal cell; animal experiment; animal model; animal tissue; antifibrotic activity; antifibrotic therapy; antiinflammatory activity; Article; bleaching; bone microarchitecture; bone volume; bone volume fraction; chemiluminescence immunoassay; controlled study; drug distribution; drug tissue level; electrophoresis; enzyme linked immunosorbent assay; exosome; fluorescence intensity; fluorescence microscopy; HEK293-FT cell line; Hep-G2 cell line; high-fat diet-induced fatty liver; high-fat diet-induced inflammation; high-fat diet-induced steatohepatitis; human; human cell; imaging and display; immunocytochemistry; inflammation; isolation and purification; Lentivirus; lipid storage; liver fibrosis; liver protection; male; metabolic disorder; metabolic fatty liver; mouse; nanoencapsulation; nanoengineering; nanoparticle tracking analysis; nonhuman; particle size; quantitative analysis; real time polymerase chain reaction; RNA extraction; stable transfection; steatohepatitis; subcutaneous white adipose tissue; Western blotting; animal; C57BL mouse; cell line; chemistry; fatty liver; genetics; lipid diet; liver; metabolism; pathology; therapy; Fibroblasts ⓘ English 2025 2025-10 10.1016/j.biomaterials.2025.123321 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Event-Triggered Generalized Extended State Observer-Based Control for Nonlinear Networked Systems Under Gain Variation and Multi-Channel Attacks ⓘ This paper investigates the event-triggered generalized extended state observer-based estimation issue for a class of nonlinear networked control systems with unmodeled dynamics, external disturbances and multi-channel attacks. In order to resist different forms of attack threats on multiple communication channels from sensors to the observer, Markov chain is introduced to describe the stochastic switching or jumping behavior between different attack modes. Considering the limited network resources, the measured outputs are transmitted to the observer only when the triggering conditions are met. Moreover, the parameters modeled by the Bernoulli process are adopted to help analyze potential random gain variations of the generalized extended state observer. By employing Lyapunov stability theory and stochastic systems analysis, sufficient conditions are derived to ensure that the augmented system is exponentially bounded in mean square, and the expected observer gains are further determined through linear matrix inequalities. Finally, a numerical example and a simulation related to the RLC series circuit system are conducted, illustrating the proposed method's effectiveness. ⓘ Zhang, Pengcheng; Wang, Jianyu; Liu, Yajuan; Lee, Sangmoon ⓘ Nanjing Univ Sci & Technol, Sch Automat, Nanjing, Peoples R China; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea; North China Elect Power Univ, Sch Control & Comp Engn, Beijing, Peoples R China ⓘ ; Lee, Sangmoon/C-4502-2018; Yajuan, Liu/JZD-8537-2024; zhang, pengcheng/B-2618-2008; Lee, Seunghoon/AAR-6570-2020 ⓘ 58043447700; 57211089817; 55255775300; 59510733500 ⓘ moony@knu.ac.kr; ⓘ INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL ⓘ INT J ROBUST NONLIN ⓘ 1049-8923 1099-1239 35 3 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;MATHEMATICS, APPLIED ⓘ 2024 3.2 3.6 0 2025-05-07 ⓘ 0 0 event-triggered mechanism; generalized extended state observer; multi-channel attacks; networked control systems; observer gain variation ⓘ H-INFINITY CONTROL; SYNCHRONIZATION; COMMUNICATION ⓘ event-triggered mechanism; generalized extended state observer; multi-channel attacks; networked control systems; observer gain variation ⓘ Control system analysis; Convergence of numerical methods; Markov chains; Networked control systems; Nonlinear control systems; Nonlinear network analysis; State estimation; Stochastic control systems; Condition; Event-triggered; Event-triggered mechanism; Gain variations; Generalized extended state observers; Multi channel; Multi-channel attack; Networked controls; Observer gain; Observer gain variation; Stochastic systems ⓘ English 2025 2025-02 10.1002/rnc.7681 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Helicobacter pylori VacA-induced mitochondrial damage in the gastric pit cells of the antrum and therapeutic rescue ⓘ Exploring host cell specificity, pathogenicity, and molecular mechanisms of the vacuolating cytotoxin A (VacA), secreted by Helicobacter pylori (Hp) is crucial for developing novel treatment strategies. VacA affects subcellular events, particularly mitochondria, at a cell-type-specific level. However, the lack of reliable models that mimic VacA-induced subcellular damages and enable novel drug screening linked to the human stomach clinically limits our understanding of the mitochondrial networks in vivo. Here, human antrum gastric organoids (hAGOs) and tissue samples from Hp-infected patients were used to show the toxic effects of VacA-induced mitochondrial damage mainly in mucus-producing gastric pit cells by employing transcriptional, translational, and functional analyses. In VacA-intoxicated or Hp-infected hAGOs, robust mitochondrial fragmentation in gastric pit cells reduced ATP production during respiration, and loss of mucosal barrier integrity was first demonstrated experimentally. Using hAGOs, clinically relevant small molecules were screened for efficacy, and MLN8054, an Aurora kinase A inhibitor, reversed VacA-induced mitochondrial damage and loss of gastric epithelium integrity. MLN8054 was effective in VacA-treated and Hp-infected hAGOs and mice, highlighting hAGOs as a promising drug-screening model. These findings suggest that mitochondrial quality control may serve as a promising therapeutic target for Hp VacA-mediated toxicity and disease progression. ⓘ Son, Ye Seul; Kwon, Yong Hwan; Lee, Moo-Seung; Kwon, Ohman; Jeong, Yu-Jin; Mun, Seon Ju; Jeon, Sojeong; Park, Ji Hye; Han, Man-Hoon; Bae, Jae-sung; Hur, Keun; Jang, Ah-Ra; Park, Jong-Hwan; Cho, Hyun-Soo; Jung, Cho-Rok; Ryu, Choong-Min; Son, Myung Jin; Park, Doo-Sang; Son, Mi-Young ⓘ Korea Res Inst Biosci & Biotechnol KRIBB, Daejeon 34141, South Korea; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu 41944, South Korea; Korea Univ Sci & Technol, KRIBB Sch Biosci, Daejeon 34113, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pathol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Physiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Biochem & Cell Biol, Daegu 41944, South Korea; Chonnam Natl Univ, Coll Vet Med, Lab Anim Med, Gwangju 61186, South Korea; Korea Res Inst Biosci & Biotechnol, Biol Resource Ctr, Korean Collect Type Cultures, Jeongeup 56212, South Korea; Sungkyunkwan Univ, Dept Biol Sci, Suwon 16419, South Korea ⓘ ; Hur, Keun/G-9513-2011; Bae, Jae-sung/AAM-8663-2021 ⓘ 56501340900; 58950750100; 55626176100; 57203265993; 24390894200; 57202288110; 58849445500; 57250156800; 57194067936; 35209510400; 8861888000; 57196049899; 15838687800; 56508722000; 57194011220; 7101906863; 7004301407; 17233878700; 7004301289 ⓘ mjson@kribb.re.kr; dspark@kribb.re.kr; myson@kribb.re.kr; ⓘ BIOMATERIALS ⓘ BIOMATERIALS ⓘ 0142-9612 1878-5905 314 SCIE ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 12.9 3.6 2.33 2025-05-07 ⓘ 2 2 Helicobacter pylori VacA; Human antrum gastric organoid; Gastric pit cells; Mucus-producing cells; Mitochondrial dysfunction ⓘ VACUOLATING CYTOTOXIN; AURORA KINASE; MUCOSAL BARRIER; CANCER; INHIBITION; MICE; EXPRESSION; INDUCTION; INFECTION; CARCINOMA ⓘ Gastric pit cells; Helicobacter pylori VacA; Human antrum gastric organoid; Mitochondrial dysfunction; Mucus-producing cells ⓘ Animals; Bacterial Proteins; Gastric Mucosa; Helicobacter Infections; Helicobacter pylori; Humans; Mice; Mitochondria; Organoids; Pyloric Antrum; Controlled drug delivery; Damage detection; Disease control; 4 [[9 chloro 7 (2,6 difluorophenyl) 5h pyrimido[5,4 d][2]benzazepin 2 yl]amino]benzoic acid; 4',6 diamidino 2 phenylindole; adenosine triphosphate; carbonyl cyanide 4 (trifluoromethoxy)phenylhydrazone; caspase 3; claudin 1; claudin 7; cystic fibrosis transmembrane conductance regulator; cytotoxin; glutamine; hepatocyte nuclear factor 6; mercaptoethanol; mucin 5AC; mucin 6; noggin; nystatin; oligomycin; penicillin derivative; streptomycin; succinate dehydrogenase; transcriptome; ubiquinone; vancomycin; bacterial protein; VacA protein, Helicobacter pylori; Cytotoxins; Gastric pit cell; Helicobacter pylori; Helicobacter pylorus vacuolating cytotoxin A; Human antrum gastric organoid; Mitochondrial damage; Mitochondrial dysfunction; Mucus-producing cell; Organoids; Sub-cellular; animal cell; animal experiment; animal model; animal tissue; apoptosis; Article; cell composition; cell infiltration; cell proliferation; cell viability; controlled study; demographics; disease exacerbation; disorders of mitochondrial functions; drug screening; gastric cell line; H9 cell line; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; immunocytochemistry; immunofluorescence assay; immunohistochemistry; in vivo study; intestinal organoid; karyotyping; male; microarray analysis; micromanipulation; mitochondrial dynamics; mitochondrial membrane potential; mitochondrial respiration; molecular biology; mouse; nonhuman; organoid; oxidative phosphorylation; oxygen consumption; oxygen consumption rate; pathogenicity; prospective study; protein assembly; protein expression; protein localization; real time polymerase chain reaction; stomach antrum; stomach epithelium; stomach mucus; Western blotting; animal; drug effect; drug therapy; Helicobacter infection; metabolism; microbiology; mitochondrion; pathology; stomach antrum; stomach mucosa; Mitochondria ⓘ English 2025 2025-03 10.1016/j.biomaterials.2024.122842 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Hierarchical protein nano-crystalline hydrogel with extracellular vesicles for ectopic lymphoid structure formation ⓘ Among cancer therapies, immune checkpoint blockade (ICB) has emerged as a prominent approach, substantially enhancing anti-tumor immune responses. However, the efficacy of ICB is often limited in the absence of a preexisting immune response within the tumor microenvironment. Here, we introduce a novel hierarchical protein hydrogel platform designed to facilitate the formation of artificial tertiary lymphoid structures (aTLS), thereby improving ICB efficacy. Through the integration of self-assembling ferritin protein nanocages, rec1-resilin protein, and CP05 peptide, our hierarchical hydrogels provide a structurally supportive and functionally adaptive scaffold capable of on-demand self-repair in response to mild thermal treatments. The effective encapsulation of extracellular vesicles (EVs) via the CP05 peptide ensures the formation of aTLS with germinal center-like structures within the hierarchical hydrogel. We demonstrate that, combined with ICB therapy, EV-loaded hierarchical hydrogels also induce the TLS within the tumor, markedly promoting immune responses against ICBresistant tumor. This bioactive hydrogel platform offers a versatile tool for enhancing a broad range of immunotherapies, with potential applications extending beyond TLS to other frameworks that support complex tissue architectures. ⓘ Ahn, Wonkyung; Han, Jihoon; Kim, Nayeon; Hwang, Yeong Ha; Kim, Wonjun; Lee, Yeram; Lee, Dong Yun; Cheong, In Woo; Han, Koohee; Nam, Gi-Hoon; Kim, In-San; Lee, Eun Jung ⓘ Kyungpook Natl Univ, Sch Chem Engn & Appl Chem, Dept Chem Engn, Daegu 41566, South Korea; Korea Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 02841, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02842, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Chem & Biol Integrat Res Ctr, Seoul 02792, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Chem Engn & Appl Chem, Dept Appl Chem, Daegu 41566, South Korea ⓘ Lee, Eun-Jung/HDN-0608-2022 ⓘ 57222252868; 57303704000; 59884547500; 58284412000; 57221789815; 57370627900; 57211001605; 7006733373; 57192061329; 57192919427; 34770432800; 57239965200 ⓘ iskim14@kist.re.kr; eunjunglee@knu.ac.kr; ⓘ BIOMATERIALS ⓘ BIOMATERIALS ⓘ 0142-9612 1878-5905 318 SCIE ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 12.9 3.6 0 2025-05-07 ⓘ 1 0 Protein nano-crystalline; Hierarchical hydrogel; Extracellular vesicles; Artificial tertiary lymphoid structure; Cancer immunotherapy ⓘ FOLLICULAR DENDRITIC CELLS; B-CELLS; IMMUNOTHERAPY; INDUCTION; BIOMATERIALS; ANGIOGENESIS; FERRITIN; IMMUNITY; SURVIVAL; BEHAVIOR ⓘ Artificial tertiary lymphoid structure; Cancer immunotherapy; Extracellular vesicles; Hierarchical hydrogel; Protein nano-crystalline ⓘ Animals; Cell Line, Tumor; Extracellular Vesicles; Female; Ferritins; Humans; Hydrogels; Mice; Mice, Inbred BALB C; Tumor Microenvironment; Microgels; Nanogels; Scaffolds; Scaffolds (biology); CD63 antigen; CD81 antigen; CP05 peptide; CXCL13 chemokine; ferritin nanocage; hierarchical protein nano crystalline hydrogel; hydrogel; immune checkpoint inhibitor; intercellular adhesion molecule 1; interleukin 13; interleukin 23; nanocage; peptide; secondary lymphoid tissue chemokine; tumor necrosis factor; tumor susceptibility gene 101 protein; unclassified drug; ferritin; Artificial tertiary lymphoid structure; Cancer immunotherapy; Cancer therapy; Extracellular; Extracellular vesicle; Hierarchical hydrogel; Immune response; Nanocrystallines; Protein nano-crystalline; Structure formations; affinity chromatography; animal cell; animal experiment; animal model; animal tissue; Article; atomic force microscopy; binding affinity; biocompatibility; biodegradation; cancer immunotherapy; CD4+ T lymphocyte; CD8+ T lymphocyte; cell infiltration; controlled study; crystal structure; CT26 cell line; differential scanning calorimetry; Drosophila melanogaster; encapsulation; Escherichia coli; exosome; flow cytometry; Fourier transform infrared spectroscopy; gene; immune response; immunoblotting; immunofluorescence; immunohistochemistry; male; mouse; nanofabrication; nonhuman; pH; photon correlation spectroscopy; polymerase chain reaction; porosity; protein expression; protein purification; rec1 gene; scanning electron microscopy; size exclusion chromatography; temperature; tertiary lymphoid structure; transmission electron microscopy; tumor burden; animal; Bagg albino mouse; chemistry; drug effect; female; human; metabolism; tumor cell line; tumor microenvironment; Tumors ⓘ English 2025 2025-07 10.1016/j.biomaterials.2025.123166 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Probability-Based Finite-Time Security Control for Switched Stochastic Systems via a Novel Event-Triggered Mechanism and Its Application ⓘ This article discusses the finite-time boundedness (FTB) issue and L2$$ {L}₂ $$-gain analysis for switched stochastic systems, particularly under the dual influence of DoS attacks and false data injection attacks, by employing a novel event-triggered mechanism. Different from the moment calculation method, a probability-based FTB is studied which offers more pertinence. To obtain a less conservative condition of FTB, a switched Lyapunov function is constructed. Additionally, a memory-based dynamic event-triggered mechanism is designed to reduce the amounts of triggering and mitigate the state response fluctuations. Based on the incomplete information above, state feedback controllers are devised to satisfy stochastic FTB, ensuring the successful attainment of finite-time L2$$ {L}₂ $$-gain. Sufficient conditions are cast into a convex optimization problem by LMIs which can be solved easily. Finally, a compared numerical example and an RLC series circuit are adopted to demonstrate the availability of the theoretical results. ⓘ Xia, Yude; Lin, Xiangze; Lee, S. M. ⓘ Nanjing Agr Univ, Coll Artificial Intelligence, Nanjing, Peoples R China; Kyungpook Natl Univ, Sch Elect & Elect Engn, Daegu, South Korea ⓘ Xia, YuDe/LPP-2921-2024; Lee, Sangmoon/C-4502-2018; Lin, Xiangze/AAE-2466-2019 ⓘ 57212390527; 12773830400; 59812532700 ⓘ xzlin@njau.edu.cn; moony@knu.ac.kr; ⓘ INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONTROL ⓘ INT J ROBUST NONLIN ⓘ 1049-8923 1099-1239 35 2 SCIE AUTOMATION & CONTROL SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;MATHEMATICS, APPLIED ⓘ 2024 3.2 3.6 0 2025-05-07 ⓘ 0 0 finite-time boundedness; memory-based dynamic event-triggered mechanism; network attacks; switched stochastic system ⓘ H-INFINITY CONTROL; NONLINEAR-SYSTEMS ⓘ finite-time boundedness; memory-based dynamic event-triggered mechanism; network attacks; switched stochastic system ⓘ Feedback control; Lyapunov functions; State feedback; Stochastic control systems; Stochastic systems; Dynamic events; Event-triggered; Finite-time; Finite-time boundedness; Gain analysis; ITS applications; Memory-based dynamic event-triggered mechanism; Network attack; Security controls; Switched stochastic systems; Convex optimization ⓘ English 2025 2025-01-25 10.1002/rnc.7663 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for targeted treatment of lung cancer ⓘ Inhalation delivery has been considered a promising choice for treating lung cancer because it can shuttle therapeutic payloads directly to cancer tissues via simple and noninvasive procedures while reducing systemic toxicity. However, its clinical application still faces challenges, especially for delivering hydrophobic chemotherapeutic drugs, due to poor absorption on mucosal tissues and limited therapeutic performance. Herein, we propose inhalable mucoadhesive proteinic nanoparticles (NPs) capable of facilitating reliable pulmonary drug delivery and redox-responsive anticancer therapeutic effects to realize noninvasive, localized treatment of lung cancer in a highly biocompatible, site-specific manner. Thiolated mussel adhesive protein (MAP)-based NPs (thMAP NPs) can be administered to target tissues via an easy and facile nebulization process due to their superior MAP-driven adhesion ability and sufficient structural integrity. Curcumin (Cur)-loaded thMAP NPs (thMAP@Cur NPs) demonstrated efficient cellular uptake through the thiol-mediated pathway and controlled the intracellular release of Cur in response to the reductive environment in cancer cells. The nebulized thMAP@Cur NPs elicited prolonged retention in lung tissue without causing any detectable adverse effects, leading to significant inhibition of metastatic lung cancer in vivo. Thus, these protein-based redox-responsive mucoadhesive NPs hold great promise as robust inhalable drug delivery platforms to achieve effective, localized treatment of pulmonary cancer and other respiratory diseases. ⓘ Jeong, Yeonsu; Shim, Yun Seop; Jo, Yun Kee; Cha, Hyung Joon ⓘ Pohang Univ Sci & Technol, Dept Chem Engn, Pohang 37673, South Korea; Kyungpook Natl Univ, Adv Inst Sci & Technol, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41944, South Korea; Pohang Univ Sci & Technol, Sch Convergence Sci & Technol, Med Sci & Engn, Pohang 37673, South Korea ⓘ Joon, Hyung/AAO-8422-2020 ⓘ 57203275643; 59471648100; 56123757800; 55954303800 ⓘ ykjo@knu.ac.kr; hjcha@postech.ac.kr; ⓘ BIOMATERIALS ⓘ BIOMATERIALS ⓘ 0142-9612 1878-5905 316 SCIE ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS ⓘ 2024 12.9 3.6 0 2025-05-07 ⓘ 1 2 Redox-responsive nanotherapeutics; Inhalable drug delivery; Mucoadhesive proteinic nanoparticle; Lung cancer therapy; Antioxidant activity ⓘ CELLULAR UPTAKE; DRUG; DELIVERY; NANOPARTICLE; CURCUMIN; GLUTATHIONE; INHALATION; THIOLS; MUCUS ⓘ Antioxidant activity; Inhalable drug delivery; Lung cancer therapy; Mucoadhesive proteinic nanoparticle; Redox-responsive nanotherapeutics ⓘ Adhesiveness; Administration, Inhalation; Animals; Antineoplastic Agents; Cell Line, Tumor; Curcumin; Drug Delivery Systems; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Nanoparticles; Oxidation-Reduction; Proteins; Controlled drug delivery; Nanoparticles; Targeted drug delivery; curcumin; mussel adhesive protein; nanoparticle; redox inhalable mucoadhesive proteinic nanoparticle; unclassified drug; adhesive protein, mussel; antineoplastic agent; curcumin; protein; Antioxidant activities; Curcumin; Inhalable drug; Inhalable drug delivery; Lung Cancer; Lung cancer therapy; Mucoadhesive proteinic nanoparticle; Mucoadhesives; Redox-responsive; Redox-responsive nanotherapeutic; A-549 cell line; absorption spectrophotometry; animal experiment; animal model; animal tissue; antineoplastic activity; Article; cancer therapy; cell viability; cell viability assay; cytotoxicity; drug delivery system; field emission scanning electron microscopy; flow cytometry; fluorescence intensity; fluorescence microscopy; Fourier transform infrared spectroscopy; HaCat cell line; histology; human; human cell; in vitro study; in vivo study; Kruskal Wallis test; lung cancer; lung parenchyma; mucoadhesion; nanotechnology; nanotherapeutics; nonhuman; photon correlation spectroscopy; polyacrylamide gel electrophoresis; ultraviolet spectrophotometry; adhesion; animal; Bagg albino mouse; chemistry; drug therapy; inhalational drug administration; lung tumor; mouse; oxidation reduction reaction; pathology; tumor cell line; Lung cancer ⓘ English 2025 2025-05 10.1016/j.biomaterials.2024.123004 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Scaling of nodal resilience and influence in complex dynamical networks ⓘ In complex dynamical networks, the resilience of the individual nodes against perturbation and their influence on the network dynamics are of great interest and have been actively investigated. We consider situations where the coupling dynamics are separable, which arise in certain classes of dynamical processes including epidemic spreading, population dynamics, and regulatory processes, and derive the algebraic scaling relations characterizing the nodal resilience and influence. Utilizing synthetic and empirical networks of different topologies, we numerically verify the scaling associated with the dynamical processes. Our results provide insights into the interplay between network topology and dynamics for the class of processes with separable coupling functions. ⓘ Han, Li-Lei; Zeng, Lang; Choi, Hayoung; Lai, Ying-Cheng; Do, Younghae ⓘ Kyungpook Natl Univ, Nonlinear Dynam & Math Applicat Ctr, Dept Math, Daegu 41566, South Korea; Arizona State Univ, Sch Elect Comp & Energy Engn, Tempe, AZ 85287 USA; Arizona State Univ, Dept Phys, Tempe, AZ 85287 USA ⓘ ; Do, Younghae/G-3522-2011 ⓘ 57216767091; 57219643973; 56942685000; 7401512359; 7103101109 ⓘ yhdo@knu.ac.kr; ⓘ CHAOS ⓘ CHAOS ⓘ 1054-1500 1089-7682 35 5 SCIE MATHEMATICS, APPLIED;PHYSICS, MATHEMATICAL ⓘ 2024 3.2 3.6 N/A ⓘ 0 0 ⓘ PROPAGATION; MAP ⓘ ⓘ article; epidemic; human; male; population dynamics ⓘ English 2025 2025-05 10.1063/5.0254365 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Simultaneous passivation of surface and bulk defects in all-perovskite tandem solar cells using bifunctional lithium salts ⓘ All-perovskite tandem solar cells have garnered considerable attention because of their potential to outperform single-junction cells. However, charge recombination losses within narrow-bandgap (NBG) perovskite subcells hamper the advancement of this technology. Herein, we introduce a lithium salt, lithium bis(trifluoromethanesulfonyl)imide (LiTFSI), for modifying NBG perovskites. Interestingly, LiTFSI bifunctionally passivates the surface and bulk of NBG by dissociating into Li+ and TFSI- ions. We found that TFSI- passivates halide vacancies on the perovskite surface, reducing nonradiative recombination, while Li+ acts as an interstitial n-type dopant, mitigating the defects of NBG perovskites and potentially suppressing halide migration. Furthermore, the underlying mechanism of LiTFSI passivation was investigated through the density functional theory calculations. Accordingly, LiTFSI facilitates charge extraction and extends the charge carrier lifetime, resulting in an NBG device with power conversion efficiency (PCE) of 22.04% (certified PCE of 21.42%) and an exceptional fill factor of 81.92%. This enables the fabrication of all-perovskite tandem solar cells with PCEs of 27.47% and 26.27% for aperture areas of 0.0935 and 1.02 cm2, respectively.image ⓘ Yun, Yeonghun; Vidyasagar, Devthade; Kim, Sunwoo; Yang, Sung Woong; Im, Doyun; Gunasekaran, Rajendra Kumar; Lee, Sangheon; Jung, Jina; Choi, Won Chang; Chung, Roy Byung Kyu; Kim, Dong Hoe; Park, Ji-Sang; Lee, Sangwook ⓘ Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Helmholtz Zentrum Berlin Mat & Energie GmbH, Dept Perovskite Tandem Solar Cells, Berlin, Germany; Korea Univ, Dept Mat Sci & Engn, Seoul 02841, South Korea; Sungkyunkwan Univ, SKKU Adv Inst Nano Technol, Suwon 16419, South Korea ⓘ Park, Ji-Sang/F-9944-2010; Gunasekaran, Rajendra Kumar/ISU-5759-2023; Lee, Sangwook/O-9166-2015; Vidyasagar, Devthade/O-3930-2015 ⓘ 57202548363; 57201674442; 59410048500; 58055005400; 58786742800; 57201582809; 57051617400; 57222277455; 57306430400; 16642183100; 56366898500; 36671796300; 57203597324 ⓘ donghoekim@korea.ac.kr; jisangpark@skku.edu; wook2@knu.ac.kr; ⓘ INFOMAT ⓘ INFOMAT ⓘ 2567-3165 7 4 SCIE MATERIALS SCIENCE, MULTIDISCIPLINARY ⓘ 2024 22.3 3.6 0 2025-05-07 ⓘ 1 1 all-perovskite tandem solar cells; defect passivation; LiTFSI salt; narrow-bandgap perovskites; nonradiative charge recombination ⓘ SPIRO-OMETAD LAYER; DEGRADATION; EFFICIENT; MIGRATION; METHYLAMMONIUM ⓘ all-perovskite tandem solar cells; defect passivation; LiTFSI salt; narrow-bandgap perovskites; nonradiative charge recombination ⓘ ⓘ English 2025 2025-04 10.1002/inf2.12656 ⓘ 바로가기 바로가기 바로가기 바로가기
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