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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Forward-Looking Multimodal Endoscopic System Based on Optical Multispectral and High-Frequency Ultrasound Imaging Techniques for Tumor Detection | We developed a forward-looking (FL) multimodal endoscopic system that offers color, spectral classified, high-frequency ultrasound (HFUS) B-mode, and integrated backscattering coefficient (IBC) images for tumor detection in situ. Examination of tumor distributions from the surface of the colon to deeper inside is essential for determining a treatment plan of cancer. For example, the submucosal invasion depth of tumors in addition to the tumor distributions on the colon surface is used as an indicator of whether the endoscopic dissection would be operated. Thus, we devised the FL multimodal endoscopic system to offer information on the tumor distribution from the surface to deep tissue with high accuracy. This system was evaluated with bilayer gelatin phantoms which have different properties at each layer of the phantom in a lateral direction. After evaluating the system with phantoms, it was employed to characterize forty human colon tissues excised from cancer patients. The proposed system could allow us to obtain highly resolved chemical, anatomical, and macro-molecular information on excised colon tissues including tumors, thus enhancing the detection of tumor distributions from the surface to deep tissue. These results suggest that the FL multimodal endoscopic system could be an innovative screening instrument for quantitative tumor characterization. | Kim, Jihun; Lew, Hah Min; Kim, Jung-Hee; Youn, Sangyeon; Al Faruque, Hasan; Seo, An Na; Park, Soo Yeun; Chang, Jin Ho; Kim, Eunjoo; Hwang, Jae Youn | Daegu Gyeongbuk Inst Sci & Technol DGIST, Dept Informat & Commun Engn ICE, Daegu 42988, South Korea; Univ Notre Dame, Aerosp & Mech Engn, Notre Dame, IN 46556 USA; DGIST, Dept ICE, Daegu 42988, South Korea; DGIST, Compan Diagnost & Med Technol Res Grp, Daegu 42988, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Sch Med, Dept Pathol, Daegu 41566, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Colorectal Canc Ctr, Sch Med, Daegu 41566, South Korea | ; Kim, Jihun/ABY-7662-2022; Al, Faruque/U-9865-2019 | 57189691294; 57221926012; 57203324973; 57192304890; 57190061983; 55804153700; 40561578300; 55699698900; 57201857413; 57838218600 | jkim75@nd.edu;rpm0130@dgist.ac.kr;cell84@dgist.ac.kr;ttorxp12@dgist.ac.kr;hasan@dgist.ac.kr;san_0729@naver.com;psy-flower@hanmail.net;jhchang@dgist.ac.kr;ejkim@dgist.ac.kr;jyhwang@dgist.ac.kr; | IEEE TRANSACTIONS ON MEDICAL IMAGING | IEEE T MED IMAGING | 0278-0062 | 1558-254X | 40 | 2 | SCIE | COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS;ENGINEERING, BIOMEDICAL;ENGINEERING, ELECTRICAL & ELECTRONIC;IMAGING SCIENCE & PHOTOGRAPHIC TECHNOLOGY;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2021 | 11.037 | 3.3 | 0.51 | 2025-07-30 | 7 | 9 | Tumors; Ultrasonic imaging; Optical imaging; Biomedical optical imaging; Probes; Optical sensors; Multimodal endoscopic system; forward-looking; multispectral imaging; high-frequency ultrasound imaging; colorectal tumor | VIEWING ECHOENDOSCOPE; COHERENCE TOMOGRAPHY; COLORECTAL-CANCER; COLON-CANCER; TISSUE; DIAGNOSIS; LESIONS; AUTOFLUORESCENCE; CHROMOENDOSCOPY; EXCITATION | colorectal tumor; forward-looking; high-frequency ultrasound imaging; Multimodal endoscopic system; multispectral imaging | Colon; Endoscopy; Humans; Phantoms, Imaging; Radiopharmaceuticals; Ultrasonography; Backscattering; Chemical detection; Diseases; Endoscopy; Histology; Phantoms; Ultrasonic imaging; gelatin; radiopharmaceutical agent; Endoscopic systems; High-frequency ultrasound; High-frequency ultrasound imaging; Integrated backscattering; Lateral directions; Molecular information; Screening instruments; Tumor characterization; Article; autocorrelation; autofluorescence; B scan; bilayer membrane; cancer diagnosis; cancer patient; clinical article; colon cancer; colon mucosa; colon tissue; colonoscopy; contrast to noise ratio; controlled study; data analysis software; diagnostic accuracy; diagnostic test accuracy study; dissection; endoscopic ultrasonography; excision; fluorescence imaging; high frequency ultrasound; human; human tissue; multimodal imaging; multispectral imaging; sensitivity and specificity; signal noise ratio; submucosa; tumor invasion; ultraviolet radiation; white light; colon; diagnostic imaging; echography; endoscopy; imaging phantom; Tumors | English | 2021 | 2021-02 | 10.1109/tmi.2020.3032275 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2 | Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the discovery of a new type of histone posttranslational modification, lysine methacrylation (Kmea), corresponding to a structural isomer of crotonyllysine. We validate the identity of this modification using diverse chemical approaches and further confirm the occurrence of this type of histone mark by pan specific and site-specific anti-methacryllysine antibodies. In total, we identify 27 Kmea modified histone sites in HeLa cells using affinity enrichment with a pan Kmea antibody and mass spectrometry. Subsequent biochemical studies show that histone Kmea is a dynamic mark, which is controlled by HAT1 as a methacryltransferase and SIRT2 as a de-methacrylase. Altogether, these investigations uncover a new type of enzyme-catalyzed histone modification and suggest that methacrylyl-CoA generating metabolism is part of a growing number of epigenome-associated metabolic pathways. | Delaney, Kyle; Tan, Minjia; Zhu, Zhesi; Gao, Jinjun; Dai, Lunzhi; Kim, Sunjoo; Ding, Jun; He, Maomao; Halabelian, Levon; Yang, Lu; Nagarajan, Prabakaran; Parthun, Mark Robert; Lee, Sangkyu; Khochbin, Saadi; Zheng, Yujun George; Zhao, Yingming | Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA; Univ Georgia, Dept Pharmaceut & Biomed Sci, Athens, GA 30602 USA; Kyungpook Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Daegu, South Korea; Univ Toronto, Struct Genom Consortium, Toronto, ON, Canada; Ohio State Univ, Dept Biol Chem & Pharmacol, Columbus, OH 43210 USA; Univ Grenoble Alpes, Inst Adv Biosci, CNRS, INSERM,U1209,UMR 5309, Grenoble, France; Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China; Sichuan Univ, West China Hosp, Dept Gen Practice, State Key Lab Biotherapy, Chengdu, Peoples R China; Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China | ; NAGARAJAN, PRABAKARAN/AAA-2881-2020; Zheng, Yujun/P-8975-2014; Tan, Minjia/C-4491-2014; Yang, Lu/AEI-0948-2022; Gao, Jinjun/AGQ-9202-2022 | 57222267682; 36027735400; 57221653171; 57202825394; 37033682800; 57051715600; 36190719600; 57193427189; 56030426800; 57102076600; 24171654400; 6603908670; 57209046767; 26643421700; 35204159700; 7407404510 | yingming.zhao@uchicago.edu; | CELL DISCOVERY | CELL DISCOV | 2056-5968 | 7 | 1 | SCIE | CELL BIOLOGY | 2021 | 38.09 | 3.3 | 1.87 | 2025-07-30 | 41 | 38 | METABOLIC-REGULATION; GENE-EXPRESSION; SUBSTRATE-SPECIFICITY; CROTONYLATION; ACETYLTRANSFERASE; ACETYLATION; CHROMATIN; YEAST; TRANSCRIPTION; MALONYLATION | histone H4; methacrylic acid; sirtuin 2; synthetic peptide; Article; biocatalysis; comparative study; controlled study; epigenome; HeLa cell line; high performance liquid chromatography; histone acetylation; histone modification; human; immunoblotting; immunochemistry; in vitro study; isomer; isotope labeling; mass spectrometry; ozonolysis; protein processing; regulatory mechanism | English | 2021 | 2021-12-28 | 10.1038/s41421-021-00344-4 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||||
| ○ | ○ | Article | Strength characteristics of spent coffee grounds and oyster shells cemented with GGBS-based alkaline-activated materials | This study examined the use of by-product materials such as spent coffee grounds (SCGs), oyster shell (OS), and ground-granulated blast furnace slag (GGBS) for geotechnical applications. To improve the granular skeletons of the highly compressive particles of SCG, the OS were added to a mixture in forms of grinding powder (OS.P) or crushed-granular (OS.G) acting as fill factor in terms of physical interaction, whereas GGBS was only precursor material for alkali-activated materials (AAMs). The OS.P and OS.G were employed at various OS:SCG ratios, by weight. The mixtures were cemented using GGBS-based AAMs activated by a sodium hydroxide solution (SH) and a mixture of sodium hydroxide and sodium silicate (SS). From the test results, several factors that affected the strength development of the samples have been observed, such as the curing time, type of alkaline solution, temperature variation, as well as form and ratio of OS. At the same curing conditions, the SS solution exhibited better strength compared with SH as significant contents of sodium (Na2O) and silicate (SiO2) were provided for the mixture. During the curing period, the temperature variation strongly affected the strength development of the samples. Generally, the strength and stiffness of the samples were improved by the incorporation of SCG with OS.P or OS.G, whereas the slake durability indices were maintained at very high to extremely high values, regardless of the OS type. The maximum unconfined compressive strength (UCS) value reached approximately 2.8 MPa, with optimal ratios of OS.P or OS.G of 0.3 or 0.5, respectively, compared with the SCG weight. At a given ratio, the blend mixture of OS.G and SCG generally exhibited better stiffness and a slightly lower unit weight than OS.P. The mineralogical and microstructure analyses revealed that there was no chemical reaction among SCG, OS.P, and OS.G particles, indicating that these materials act as fillers. In addition, the produced C-S-H gel acts as the dominant binder in this study. Moreover, the excessive addition of OS.P or OS.G caused negative results in strength and durability due to the poor bonding effects between the SCG and OS particles in granular skeletons. Thus, the addition of 50% of OS.G compared with the amount of SCG, by weight, was proposed as the optimal ratio for practical applications. (C) 2020 Elsevier Ltd. All rights reserved. | Le, Trung-Tri; Park, Sung-Sik; Lee, Jun-Cheol; Lee, Dong-Eun | Kyungpook Natl Univ, Dept Civil Engn, 80 Deahakro, Daegu 41566, South Korea; Seowon Univ, Dept Architecture, Cheongju 28674, South Korea; Kyungpook Natl Univ, Dept Architectural Engn, 80 Deahakro, Daegu 41566, South Korea | ; Le, Tri/ABA-9597-2021 | 57211376067; 36241850300; 55694062800; 56605563300 | ltrungtri@gmail.com;sungpark@knu.ac.kr;uggenius@hanmail.net;dolee@knu.ac.kr; | CONSTRUCTION AND BUILDING MATERIALS | CONSTR BUILD MATER | 0950-0618 | 1879-0526 | 267 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 7.693 | 3.3 | 1.03 | 2025-07-30 | 20 | 22 | Spent coffee ground; Oyster shell; Alkali-activated; Slag; Compressive strength | FLY-ASH; RECYCLED GLASS; SLAG; HYDRATION; WASTE; TRANSFORMATION; GEOPOLYMERS; ARAGONITE; STIFFNESS; PRODUCTS | Alkali-activated; Compressive strength; Oyster shell; Slag; Spent coffee ground | Alkalinity; Blast furnaces; Blending; Chemical analysis; Chemical bonds; Compressive strength; Curing; Durability; Molluscs; Musculoskeletal system; Shellfish; Silica; Silicates; Slags; Sodium hydroxide; Stiffness; Temperature distribution; Geotechnical application; Ground granulated blast furnace slag; Microstructure analysis; Slake durability indices; Sodium hydroxide solutions; Strength and stiffness; Strength characteristics; Unconfined compressive strength; Mixtures | English | 2021 | 2021-01-18 | 10.1016/j.conbuildmat.2020.120986 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Volume, strength, and stiffness characteristics of expandable foam grout | An expandable foam grout (EFG) is developed to fill underground cavities. The objective of this study is to evaluate the volume, strength, and stiffness of the EFG during curing using various testing methods. Flow, expansion, and unconfined compressive tests are conducted to investigate the fundamental material properties of the EFG. X-ray computed tomography is performed to verify the pore distribution of the EFG. Elastic waves and electrical resistivity are monitored to estimate the stiffness and strength characteristics of the EFG. The results show that EFG has high flowability, expanding within four hours depending on the temperature. The X-ray computed tomography images indicate a heterogeneous pore distribution in the EFG. A series of relationships between static and dynamic properties based on the elastic wave velocities and electrical resistivity are established. Furthermore, elastic wave measurement and electrical resistivity monitoring may be useful for estimating the volume, strength, and stiffness characteristics during curing. (C) 2020 Elsevier Ltd. All rights reserved. | Han, WooJin; Lee, Jong-Sub; Byun, Yong-Hoon | Korea Univ, Sch Civil Environm & Architectural Engn, 145 Anam Ro, Seoul 136713, South Korea; Kyungpook Natl Univ, Sch Agr Civil & Bioind Engn, 80 Daehak Ro, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, 80 Daehak Ro, Daegu 41566, South Korea | ; Lee, Jong-Sub/G-2752-2012; Byun, Yong-Hoon/JKI-8441-2023; Han, WooJin/KLZ-1352-2024 | 57191676149; 55690048400; 42761048000 | yhbyun@knu.ac.kr; | CONSTRUCTION AND BUILDING MATERIALS | CONSTR BUILD MATER | 0950-0618 | 1879-0526 | 274 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2021 | 7.693 | 3.3 | 1.29 | 2025-07-30 | 23 | 23 | Compressive strength; Dynamic modulus; Electrical resistivity; Expansion; Flowable fill; Pore distribution | Compressive strength; Dynamic modulus; Electrical resistivity; Expansion; Flowable fill; Pore distribution | Computerized tomography; Curing; Elastic waves; Electric conductivity; Mortar; Stiffness; Testing; Compressive tests; Dynamic moduli; Electrical resistivity; Flowable fill; Pores distribution; Strength and stiffness; Strength and stiffness characteristics; Testing method; Underground cavities; X-ray computed tomography; Compressive strength | English | 2021 | 2021-03-08 | 10.1016/j.conbuildmat.2020.122013 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Affine Transformed IT2 Fuzzy Event-Triggered Control Under Deception Attacks | Stabilization of type-2 fuzzy system in the presence of cyber attacks is investigated in this article. For a practical application, a class of nonlinear system can be represented by an interval type-2 fuzzy system through a set of membership functions. Unlike existing schemes, 1) affine membership functions are considered in the controller design; moreover, 2) a robust adaptive event-triggered control is proposed to avoid the unwanted triggering events, which makes the proposed scheme more reliable and relaxes the conservativeness of stability analysis.In the numerical simulation, the mass-spring-damper system and the tracking control system are considered to illustrate the robustness and effectiveness of the proposed approach. | Han, Seungyong; Kommuri, Suneel Kumar; Lee, Sangmoon | Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea; Xian Jiaotong Liverpool Univ, Dept Elect & Elect Engn, Suzhou 215123, Peoples R China | Han, Seungyong/AAN-8632-2021; Lee, Sangmoon/C-4502-2018 | 57200991395; 56021916300; 59510733500 | seungyong@knu.ac.kr;suneel.kommuri@xjtlu.edu.cn;moony@knu.ac.kr; | IEEE TRANSACTIONS ON FUZZY SYSTEMS | IEEE T FUZZY SYST | 1063-6706 | 1941-0034 | 29 | 2 | SCIE | COMPUTER SCIENCE, ARTIFICIAL INTELLIGENCE;ENGINEERING, ELECTRICAL & ELECTRONIC | 2021 | 12.253 | 3.4 | 5.74 | 2025-07-30 | 79 | 84 | Fuzzy systems; Nonlinear systems; Adaptive control; Symmetric matrices; Actuators; Affine transformed interval type-2 (IT2) Takagi– Sugeno (T– S) fuzzy systems; cyber– physical systems (CPSs); deception attacks; event-triggered control (ETC); linear matrix inequalities (LMIs) | CYBER-PHYSICAL SYSTEMS; LOGIC SYSTEMS; CRITERIA; DESIGN | Affine transformed interval type-2 (IT2) Takagi-Sugeno (T-S) fuzzy systems; cyber-physical systems (CPSs); deception attacks; event-triggered control (ETC); linear matrix inequalities (LMIs) | Controllers; Fuzzy systems; Network security; Controller designs; Cyber-attacks; Event-triggered controls; Mass spring damper; Robust adaptive; Stability analysis; Tracking control systems; Type-2 fuzzy systems; Membership functions | English | 2021 | 2021-02 | 10.1109/tfuzz.2020.2999779 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Review | Extracellular vesicles in cancer diagnostics and therapeutics | Cancer promotion, development, and malignant transformation is greatly influenced by cell-to-cell interactions in a complex tissue microenvironment. Cancer and stromal cells secrete soluble factors, as well as deport membrane-encapsulated structures, which actively contribute and mediate cell-to-cell interaction within a tumor microenvironment (TME). These membrane structures are recognized as extracellular vesicles (EVs), which include exosomes and microvesicles. They can carry and transport regulatory molecules such as oncogenic proteins, coding and non-coding RNAs, DNA, and lipids between neighboring cells and to distant sites. EVs medi-ate crucial pathophysiological effects such as the formation of premetastatic niches and the progression of malig-nancies. There is compelling evidence that cancer cells exhibit a significant amount of EVs, which can be released into the surrounding body fluids, compared with nonmalignant cells. EVs therefore have the potential to be used as disease indicator for the diagnosis and prognosis of cancers, as well as for facilitating research into the under-lying mechanism and biomolecular basis of these diseases. Because of their ability to transport substances, followed by their distinct immunogenicity and biocompatibility, EVs have been used to carry therapeutically-active molecules such as RNAs, proteins, short and long peptides, and various forms of drugs. In this paper, we summarize new advancement in the biogenesis and physiological roles of EVs, and underpin their functional im-pacts in the process of cancer growth and metastasis. We further highlight the therapeutic roles of EVs in the treatment, prevention, and diagnosis of human malignancies. (c) 2021 Elsevier Inc. All rights reserved. | Shehzad, Adeeb; Ul Islam, Salman; Shahzad, Raheem; Khan, Salman; Lee, Young Sup | Natl Univ Sci & Technol NUST, Sch Mech & Mfg Engn SMME, Dept Biomed Sci, H-12, Islamabad, Pakistan; Kyungpook Natl Univ, Sch Life Sci, BK21 FOUR KNU Creat BioRes Grp, Daegu 41566, South Korea; Univ Haripur, Dept Hort, Haripur, Pakistan; Quaid I Azam Univ, Dept Pharm, Islamabad, Pakistan | ; Shehzad, Adeeb/HHN-4847-2022; Shahzad, Raheem/AAG-8370-2019; Khan, Salman/F-4588-2016 | 36162526700; 56985186700; 56454250900; 54393307500; 36013628200 | yselee@knu.ac.kr; | PHARMACOLOGY & THERAPEUTICS | PHARMACOL THERAPEUT | 0163-7258 | 1879-016X | 223 | SCIE | PHARMACOLOGY & PHARMACY | 2021 | 13.4 | 3.4 | 2.21 | 2025-07-30 | 61 | 68 | Extracellular vesicles; Tumor microenvironment; Cancer metastasis; Diagnosis; Therapeutics | METASTATIC NICHE FORMATION; PROSTATE-CANCER; PREMETASTATIC NICHE; STEM-CELLS; INTERCELLULAR COMMUNICATION; CIRCULATING EXOSOMES; CISPLATIN RESISTANCE; PURIFIED EXOSOMES; COLORECTAL-CANCER; MELANOMA-CELLS | Cancer metastasis; Diagnosis; Extracellular vesicles; Therapeutics; Tumor microenvironment | Extracellular Vesicles; Humans; Neoplasms; biogenesis; cancer diagnosis; cancer growth; endosome; exosome; human; lymph node; malignant neoplasm; membrane microparticle; metastasis; priority journal; Review; tumor microenvironment; neoplasm; physiology | English | 2021 | 2021-07 | 10.1016/j.pharmthera.2021.107806 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Anticancer nanocage platforms for combined immunotherapy designed to harness immune checkpoints and deliver anticancer drugs | The interaction of programmed cell death 1 ligand 1 (PD-L1) with its receptor, programmed cell death 1 (PD-1), inhibits T cell responses. Monoclonal antibodies that block this interaction have been shown effective as immunotherapy. However, only a subset of cancers exhibits a durable response to PD-1/PD-L1 blockade. Moreover, antibody-based immune checkpoint blockade is costly and is occasionally accompanied by systemic side effects. To overcome these limitations of antibody-based immune checkpoint blockade, an immune checkpoint-blocking ferritin nanocage displaying 24 PD-L1 binding peptides (PD-L1pep1) on its surface was designed and constructed. These ferritin nanocages displaying PD-L1pep1 (PpNF) specifically bind to PD-L1 expressed on cancer cells or to purified PD-L1 with a similar to 30 nM binding affinity. The addition of PpNF to cocultures of T cells and cancer cells inhibited PD-1/PD-L1 interactions and restored T cell activities. In a mouse model of syngeneic colon cancer, PpNF specifically targeted tumors and showed antitumor activity. Moreover, PpNF nanocages encapsulating the chemotherapeutic drug doxorubicin had more potent antitumor activity than a monoclonal antibody against PD-L1. These results demonstrate that ferritin nanocages displaying surface PD-L1pep1 can be efficiently applied for immunotherapy, especially when encapsulating small chemotherapeutic drugs. These nanocages may have promise as an immunotherapeutic nanomedicine against various solid tumors. | Jeon, In Seon; Yoo, Jae Do; Gurung, Smriti; Kim, Minseong; Lee, Chanju; Park, Eun Jung; Park, Rang-Woon; Lee, Byungheon; Kim, Soyoun | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, BK21 Plus KNU Biomed Convergence Program, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, 680 Gukchaebosang Ro, Daegu 41944, South Korea; Natl Canc Ctr, Grad Sch Canc Sci & Policy, Div Canc Biomed Sci, Canc Immunol Branch, Goyang 10408, South Korea | ; Park, Eun/W-1340-2019 | 57219924195; 57216203097; 57205752137; 57221718142; 57059510700; 57092966100; 7401895636; 16304374900; 58847992000 | soyounki@knu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 270 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.304 | 3.6 | 2.11 | 2025-07-30 | 33 | 34 | PD-L1 binding peptide; Immune checkpoint; Ferritin; Immunotherapy; Combination therapy; Doxorubicin | Combination therapy; Doxorubicin; Ferritin; Immune checkpoint; Immunotherapy; PD-L1 binding peptide | Animals; Antibodies, Monoclonal; Antineoplastic Agents; Immunotherapy; Mice; Neoplasms; Programmed Cell Death 1 Receptor; Binding energy; Diseases; Drug interactions; Medical nanotechnology; Monoclonal antibodies; T-cells; Tumors; antineoplastic agent; doxorubicin; ferritin nanocage; gamma interferon; lysosome associated membrane protein 1; peptide; programmed cell death 1 ligand 1 binding peptide 1; programmed death 1 ligand 1; programmed death 1 receptor; unclassified drug; antineoplastic agent; monoclonal antibody; programmed death 1 receptor; Anti-tumor activities; Anticancer drug; Binding affinities; Binding peptide; Chemotherapeutic drugs; Immunotherapeutic; Programmed cell deaths; T-cell response; animal cell; animal experiment; animal model; antineoplastic activity; Article; binding affinity; cancer cell; cancer immunotherapy; cancer inhibition; CD8+ T lymphocyte; coculture; colon cancer; controlled study; cytotoxicity; drug delivery system; encapsulation; female; fluorescence activated cell sorting; gene expression; gene silencing; human; human cell; immune response; immunohistochemistry; lymphocyte proliferation; mouse; mouse model; nonhuman; photon correlation spectroscopy; priority journal; protein protein interaction; surface plasmon resonance; T lymphocyte activation; transmission electron microscopy; animal; immunotherapy; neoplasm; Cell death | English | 2021 | 2021-03 | 10.1016/j.biomaterials.2021.120685 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Caspase-cleavable peptide-doxorubicin conjugate in combination with CD47-antagonizing nanocage therapeutics for immune-mediated elimination of colorectal cancer | Here we report a novel combination of a caspase-cleavable peptide-doxorubicin conjugate (MPD-1) with CD47antagonizing nanocage therapeutics for the treatment of microsatellite-stable (MSS) colorectal cancer (CRC). MPD-1 (i) upregulated markers of immunogenic cell death (ICD) in tumor, and increased co-stimulatory markers on dendritic cells (DCs), (ii) enhanced CD8+ T cell infiltration and antigen presenting cell (APC) activation, and (iii) showed negligible off-target immune-related toxicity compared to free dox. Then, the CD47 antagonist FS nanocage, a SIRP alpha-expressing ferritin nanocage, was co-administered with MPD-1 that resulted in 95.2% (p < 0.001) tumor growth inhibition in an established CRC model. T cell-mediated elimination of tumors was also confirmed by the tumor-specific activation of T cells detected by IFN gamma and tumor-free mice were observed (95%) that bared a memory response when re-challenged. The strategically developed MPD-1 is an ideal adjuvant to immunotherapy and the combination with FS nanocage triggers potent immunity against MSS CRC. In summary, we present an approach to initiate and stimulate immune-mediated eradication of cancer cells using synergistic immunogenic agents targeting the MSS CRC. | Lee, Na Kyeong; Choi, Jeong Uk; Kim, Ha Rin; Chung, Seung Woo; Ko, Yoon Gun; Cho, Young Seok; Park, Seong Jin; Lee, Eun Jung; Kim, Sang Yoon; Kim, In-San; Byun, Youngro | Seoul Natl Univ, Coll Pharm, Res Inst Pharmaceut Sci, Seoul 08826, South Korea; Chonnam Natl Univ, Coll Pharm, Gwangju 61186, South Korea; Johns Hopkins Univ, Ctr Nanomed, Wilmer Eye Inst, Sch Med, Baltimore, MD 21231 USA; Pharosgen Inc, 2-404 Jangji Dong 892, Seoul 05852, South Korea; Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Daegu 41566, South Korea; Univ Ulsan, Asan Med Ctr, Dept Otolaryngol, Coll Med, Seoul 05505, South Korea; Korea Inst Sci & Technol KIST, Biomed Res Inst, Seoul 02792, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul 08826, South Korea | Cho, Young Seok/GSD-3590-2022; Lee, Seung Eun/ABG-1607-2021; Kim, Ha Rin/JLK-8663-2023 | 57188655309; 56796946900; 57202987424; 23990415400; 57239647000; 57195264293; 57226573446; 57239965200; 35183279400; 34770432800; 7102768480 | iskim14@kist.re.kr;yrbyun@snu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 277 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.304 | 3.6 | 0.99 | 2025-07-30 | 18 | 17 | Caspase-cleavable peptide-doxorubicin conju-gate; Nanocage therapeutics; CD47 antagonist; Immunotherapy combination; MSS colorectal Cancer | IMMUNOGENIC CELL-DEATH; IMMUNOTHERAPY; CHEMOTHERAPY; TUMORS | Caspase-cleavable peptide-doxorubicin conjugate; CD47 antagonist; Immunotherapy combination; MSS colorectal Cancer; Nanocage therapeutics | Animals; Caspases; CD47 Antigen; Colorectal Neoplasms; Doxorubicin; Immunotherapy; Mice; Peptides; Cell death; Chemical activation; Mammals; Peptides; Satellites; T-cells; Tumors; antineoplastic agent; caspase cleavable peptide doxorubicin conjugate; ferritin; fs nanocage; gamma interferon; nanocage; unclassified drug; caspase; CD47 antigen; doxorubicin; peptide; Caspase-cleavable peptide-doxorubicin conjugate; Caspases; Cd47 antagonist; Dendritics; Doxorubicin conjugates; Immunotherapy combination; Micro satellite; Microsatellite-stable colorectal cancer; Nanocage therapeutic; Nanocages; animal cell; animal experiment; animal model; antineoplastic activity; Article; cancer combination chemotherapy; cancer immunotherapy; cancer inhibition; colorectal cancer; controlled study; drug potency; drug potentiation; immunogenicity; immunological memory; male; mouse; nonhuman; T lymphocyte activation; tumor immunity; animal; colorectal tumor; immunotherapy; Diseases | English | 2021 | 2021-10 | 10.1016/j.biomaterials.2021.121105 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages | M2-polarized, pro-tumoral tumor-associated macrophages (TAMs) express the interleukin-4 receptor (IL4R) at higher levels compared with M1-polarized, anti-tumoral macrophages. In this study, we harnessed M1 macrophage-derived exosomes engineered to foster M1 polarization and target IL4R for the inhibition of tumor growth by reprogramming TAMs into M1-like macrophages. M1 exosomes were transfected with NF-KB p50 siRNA and miR-511-3p to enhance M1 polarization and were surface-modified with IL4RPep-1, an IL4R-binding peptide, to target the IL4 receptor of TAMs (named IL4R-Exo(si/mi). IL4R-Exo(si/mi) were internalized and downregulated target gens in M2 macrophages and decreased M2 markers, while increasing M1 markers, more efficiently compared with untargeted and control peptide-labeled exosomes and exosomes from non-immune, normal cells. Whole-body fluorescence imaging showed that IL4R-Exo(si/mi) homed to tumors at higher levels compared with the liver, unlike untargeted and control peptide-labeled exosomes. Systemic administration of IL4R-Exo(si/mi) inhibited tumor growth, downregulated target genes, and decreased the levels of M2 cytokines and immune-suppressive cells, while increasing the levels of M1 cytokines and immune-stimulatory cells, more efficiently than untargeted and control peptide-labeled exosomes. These results suggest that IL4R-Exo(si/ mi) inhibits tumor growth by reprogramming TAMs into M1-like macrophages and increasing anti-tumor immunity, thus representing a novel cancer immunotherapy. | Gunassekaran, Gowri Rangaswamy; Vadevoo, Sri Murugan Poongkavithai; Baek, Moon-Chang; Lee, Byungheon | Kyungpook Natl Univ, Sch Med, Dept Biochem & Cell Biol, 680 Gukchaebosangro, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, CMRI, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Div Biomed Sci, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Mol Med, Daegu, South Korea | 36028043400; 57216201305; 7006013097; 16304374900 | leebh@knu.ac.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 278 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.304 | 3.6 | 16.36 | 2025-07-30 | 349 | 332 | Exosome; Interleukin-4 receptor; M1 macrophage; M2 macrophage; miR-511-3p; NF-KB p50; Tumor-associated macrophage | INTERLEUKIN-4 RECEPTOR; HEPATOCELLULAR-CARCINOMA; ANTITUMOR-ACTIVITY; CELLS; CANCER; PROGRESSION; EXPRESSION; INVASION; DELIVERY; ACTIVATION | Exosome; Interleukin-4 receptor; M1 macrophage; M2 macrophage; miR-511–3p; NF-κB p50; Tumor-associated macrophage | Exosomes; Humans; Macrophages; Neoplasms; Receptors, Interleukin-4; Tumor-Associated Macrophages; Fluorescence imaging; Peptides; Polarization; Silicon; Tumors; cell marker; cysteinyl; cytokine; immunoglobulin enhancer binding protein; interleukin 4 receptor; microRNA; microRNA 511 3p; peptide; small interfering RNA; unclassified drug; interleukin 4 receptor; Cytokines; Exosomes; Inhibition of tumor growth; Interleukin-4 receptors; M1 macrophage; M2 macrophage; Mir-511–3p; NF-κb p50; Tumor growth; Tumour-associated macrophages; animal cell; Article; cancer immunotherapy; cancer inhibition; cell level; controlled study; down regulation; embryo; exosome; fluorescence imaging; gene expression regulation; human; human cell; internalization (cell); liver; M1 like macrophage; M1 macrophage; M2 macrophage; mouse; nonhuman; tumor growth; tumor immunity; tumor-associated macrophage; whole body fluorescence imaging; whole body imaging; macrophage; neoplasm; Macrophages | English | 2021 | 2021-11 | 10.1016/j.biomaterials.2021.121137 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments | Although mechanical loads are integral for musculoskeletal tissue homeostasis, overloading and traumatic events can result in tissue injury. Conventional drug delivery approaches for musculoskeletal tissue repair employ localized drug injections. However, rapid drug clearance and inadequate synchronization of molecule provision with healing progression render these methods ineffective. To overcome this, a programmable mechanores-ponsive drug delivery system was developed that utilizes the mechanical environment of the tissue during rehabilitation (for example, during cartilage repair) to trigger biomolecule provision. For this, a suite of mechanically-activated microcapsules (MAMCs) with different rupture profiles was generated in a single fabrication batch via osmotic annealing of double emulsions. MAMC physical dimensions were found to dictate mechano-activation in 2D and 3D environments and their stability in vitro and in vivo, demonstrating the tunability of this system. In models of cartilage regeneration, MAMCs did not interfere with tissue growth and activated depending on the mechanical properties of the regenerating tissue. Finally, biologically active antiinflammatory agents were encapsulated and released from MAMCs, which counteracted degradative cues and prevented the loss of matrix in living tissue environments. This unique technology has tremendous potential for implementation across a wide array of musculoskeletal conditions for enhanced repair of load-bearing tissues. | Peredo, Ana P.; Jo, Yun Kee; Duan, Gang; Dodge, George R.; Lee, Daeyeon; Mauck, Robert L. | Univ Penn, Sch Engn & Appl Sci, Dept Bioengn, Philadelphia, PA 19104 USA; Univ Penn, Perelman Sch Med, Dept Orthopaed Surg, McKay Orthopaed Res Lab, Philadelphia, PA 19104 USA; Corporal Michael J Crescenz Vet Affairs Med Ctr, Translat Musculoskeletal Res Ctr, Philadelphia, PA 19104 USA; Univ Penn, Sch Engn & Appl Sci, Dept Chem & Biomol Engn, Philadelphia, PA 19104 USA; Kyungpook Natl Univ, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea | 57190976503; 56123757800; 57200384626; 7006854038; 8882507400; 7004031805 | lemauck@pennmedicine.upenn.edu; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 265 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.304 | 3.6 | 0.99 | 2025-07-30 | 16 | 16 | Drug delivery; Tissue regeneration; Cartilage; Musculoskeletal tissues; Mechanical loading | MESENCHYMAL STEM-CELLS; DRUG-DELIVERY SYSTEMS; ARTICULAR-CARTILAGE; HYDROGELS; MATRIX; INFLAMMATION; DISEASE; DESIGN; BURDEN; IL-1RA | Cartilage; Drug delivery; Mechanical loading; Musculoskeletal tissues; Tissue regeneration | Cartilage; Regeneration; Weight-Bearing; Bearings (machine parts); Biomechanics; Biomolecules; Cartilage; Controlled drug delivery; Musculoskeletal system; Targeted drug delivery; Tissue homeostasis; Tissue regeneration; anakinra; Anti-inflammatory agents; Cartilage regeneration; Conventional drugs; Drug delivery system; Load-bearing tissues; Mechanical environment; Microenvironments; Physical dimensions; animal cell; animal experiment; animal tissue; Article; bovine; cartilage regeneration; chemical procedures; controlled study; drug delivery system; drug release; emulsion; encapsulation; in vitro study; in vivo study; male; mechanically activated microcapsule; mechano activated biomolecule; microcapsule; microenvironment; molecule; nonhuman; osmotic annealing; physical parameters; priority journal; rat; stability; tissue microenvironment; tissue regeneration; cartilage; regeneration; weight bearing; Tissue | English | 2021 | 2021-01 | 10.1016/j.biomaterials.2020.120255 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | PEGylated nanoparticle albumin-bound steroidal ginsenoside derivatives ameliorate SARS-CoV-2-mediated hyper-inflammatory responses | The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on a global scale urges prompt and effective countermeasures. Recently, a study has reported that coronavirus disease-19 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with a decrease in albumin level, an increase in NETosis, blood coagulation, and cytokine level. Here, we present drug-loaded albumin nanoparticles as a therapeutic agent to resolve the clinical outcomes observed in severe SARS-CoV-2 patients. PEGylated nanoparticle albumin-bound (PNAB) was used to promote prolonged bioactivity of steroidal ginsenoside saponins, PNAB-Rg6 and PNAB-Rgx365. Our data indicate that the application of PNAB-steroidal ginsenoside can effectively reduce histone H4 and NETosis-related factors in the plasma, and alleviate SREBP2-mediated systemic inflammation in the PBMCs of SARS-CoV-2 ICU patients. The engineered blood vessel model confirmed that these drugs are effective in suppressing blood clot formation and vascular inflammation. Moreover, the animal model experiment showed that these drugs are effective in promoting the survival rate by alleviating tissue damage and cytokine storm. Altogether, our findings suggest that these PNAB-steroidal ginsenoside drugs have potential applications in the treatment of symptoms associated with severe SARS-CoV-2 patients, such as coagulation and cytokine storm. | Park, Hee Ho; Kim, Hyelim; Lee, Han Sol; Seo, Eun U.; Kim, Ji-Eun; Lee, Jee-Hyun; Mun, Yong-Hyeon; Yoo, So-Yeol; An, Jiseon; Yun, Mi-Young; Kang, Nae-Won; Kim, Dae-Duk; Na, Dong Hee; Hong, Kyung Soo; Jang, Jong Geol; Ahn, June Hong; Bae, Jong-Sup; Song, Gyu Yong; Lee, Jae-Young; Kim, Hong Nam; Lee, Wonhwa | Kangwon Natl Univ, Dept Biotechnol & Bioengn, Chunchon 24341, Gangwon Do, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon 34134, South Korea; Korea Inst Sci & Technol KIST, Brain Sci Inst, Seoul 02792, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; AREZ Co Ltd, Daejeon 34134, South Korea; Kwangju Womens Univ, Dept Beauty Sci, Gwangju 62396, South Korea; Seoul Natl Univ, Coll Pharm, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Pharmaceut Sci, Seoul 08826, South Korea; Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Pulmonol & Allergy, Daegu 42415, South Korea; Yeungnam Univ, Med Ctr, Reg Ctr Resp Dis, Daegu 42415, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Coll Pharm, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea | Kim, Dae/D-8864-2013; Kim, Hong/D-2922-2015; Lee, Wonhwa/GLQ-6506-2022; Yoo, So-Yeol/GPK-0656-2022; Kim, Jung Oh/JDC-5061-2023; Lee, Jae-Yeong/AEP-9607-2022; Bae, Jong-Sup/AAU-9724-2020; Ahn, June/AAB-3093-2019; Kim, Hong Nam/D-2922-2015 | 25029802100; 57210146478; 59856154100; 57223314619; 55812501900; 59098097700; 57217066150; 57218382030; 57218373196; 35886891300; 57190298221; 7409759802; 7103210503; 56645558700; 56645456400; 56645445800; 16021543200; 7402253074; 56195895300; 35205791200; 50161632800 | baejs@knu.ac.kr;gysong@cnu.ac.kr;jaeyoung@cnu.ac.kr;hongnam.kim@kist.re.kr;wonhwalee@kribb.re.kr; | BIOMATERIALS | BIOMATERIALS | 0142-9612 | 1878-5905 | 273 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.304 | 3.6 | 2.51 | 2025-07-30 | 34 | 41 | Albumin; Ginsenoside; COVID-19; NETosis; Cytokine storm | EXTRACELLULAR HISTONES; NANO-THERANOSTICS; COVID-19; SEPSIS; DEATH; SHOCK; TRAP | Albumin; COVID-19; Cytokine storm; Ginsenoside; NETosis | Albumins; Animals; COVID-19; Ginsenosides; Humans; Nanoparticles; Polyethylene Glycols; SARS-CoV-2; Blood; Blood vessels; Coagulation; Drug delivery; Nanoparticles; Pathology; Storms; albumin; ginsenoside; ginsenoside Rg 365; ginsenoside Rg 6; histone H4; macrogol; nanoparticle; sterol regulatory element binding protein 2; unclassified drug; albuminoid; ginsenoside; macrogol; Albumin; Coronavirus disease-19; Cytokine storm; Cytokines; Ginsenosides; Global scale; Inflammatory response; Netosis; Pegylated nanoparticles; Severe acute respiratory syndrome coronavirus; adult; aged; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; antiviral activity; Article; blood clot; blood level; blood vessel; clinical outcome; controlled study; coronavirus disease 2019; cytokine storm; disease severity; drug delivery system; drug efficacy; human; human cell; human tissue; hyperinflammation; infection; intensive care unit; major clinical study; male; nonhuman; peripheral blood mononuclear cell; sepsis; survival rate; tissue injury; vasculitis; animal; Diseases | English | 2021 | 2021-06 | 10.1016/j.biomaterials.2021.120827 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Precomposting and green manure amendment for effective vermitransformation of hazardous coir industrial waste into enriched vermicompost | Vermitransformation of coir pith (CP) into enriched vermifertilizer has been achieved by amending a green manure plant, Sesbania sesban (SS) for the first time, and cow dung (CD) in five different combinations: T1((1:0:1)), T2((4:3:3)), T3((5:3:2)), T4((5:4:1)) and T5((1:1:0)). The substrates were 28 days precomposted with Pleurotus sajorcaju followed by 50 days vermicomposting with Eisenia fetida and Eudrilus eugeniae. Results showed a significant reduction in cellulose, lignin, organic carbon, C/N ratio, C/P ratio and an increase in plant nutrients compared to control. The fertilization index and efficiency of nutrient recovery rate were higher in SS and CD amended CP vermicompost, with a maximum in T2((4:3:3)) for E. fetida and T3((5:3:2)) for E. eugeniae. The activity of dehydrogenase, urease and cellulase, and phytotoxicity assays further revealed vermicompost stability. The study concludes that T2((4:3:3)) and T3((5:3:2)) combinations respectively for E. fetida and E. eugeniae is suitable for vermitransformation of CP into enriched vermicompost. | Karmegam, Natchimuthu; Jayakumar, Mani; Govarthanan, Muthusamy; Kumar, Ponnuchamy; Ravindran, Balasubramani; Biruntha, Muniyandi | Govt Arts Coll Autonomous, Dept Bot, Salem 636007, Tamil Nadu, India; Haramaya Univ, Haramaya Inst Technol, Dept Chem Engn, Haramaya, Dire Dawa, Ethiopia; Kyungpook Natl Univ, Dept Environm Engn, Daegu 41566, South Korea; Alagappa Univ, Dept Anim Hlth & Management, Karaikkudi 630003, Tamil Nadu, India; Kyonggi Univ, Dept Environm Energy & Engn, Gyeonggi Do 16227, South Korea | Karmegam, Natchimuthu/J-4745-2019; Muthusamy, Govarthanan/C-1491-2014; Ponnuchamy, Kumar/D-3470-2013; Mani, Jayakumar/AAU-8345-2021; Muniyandi, BIRUNTHA/G-2438-2019; Natchimuthu, Karmegam/J-4745-2019; Balasubramani, Ravindran/G-7798-2019; Govarthanan, Muthusamy/C-1491-2014 | 6506043230; 57196512530; 54881927600; 55173720800; 56295269700; 57203752025 | biruntha6675@gmail.com; | BIORESOURCE TECHNOLOGY | BIORESOURCE TECHNOL | 0960-8524 | 1873-2976 | 319 | SCIE | AGRICULTURAL ENGINEERING;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENERGY & FUELS | 2021 | 11.889 | 3.6 | 3.91 | 2025-07-30 | 79 | 91 | Coir pith; Enriched vermicompost; Green manure; Nutrient recovery; Phytotoxicity | EISENIA-FOETIDA; MATURITY; PAPER; PITH; EARTHWORMS; PHOSPHORUS; SLUDGE | Coir pith; Enriched vermicompost; Green manure; Nutrient recovery; Phytotoxicity | Coir; Control Systems; Fertilizers; Manure; Nutrients; Plants; Reduction; Stability; Animals; Cattle; Female; Hazardous Waste; Industrial Waste; Lignin; Manure; Oligochaeta; Soil; Eisenia fetida; Eudrilus eugeniae; Pleurotus sajor-caju; Sesbania sesban; Fertilizers; Green manufacturing; Nutrients; Organic carbon; carbon; cellulase; cellulose; green manure; lignin; nitrogen; organic carbon; oxidoreductase; phosphorus; trace element; urease; coir; Eisenia fetida; Eudrilus eugeniae; Nutrient recovery; Plant nutrients; Pleurotus sajor caju; Sesbania sesban; Vermi-composting; Vermicomposts; biotransformation; composting; earthworm; enzyme activity; green manuring; industrial waste; phytotoxicity; plant residue; vermiculture; Article; bulk density; cation exchange; cattle manure; composting; controlled study; Eisenia fetida; electric conductivity; enzyme activity; Eudrilus; Eudrilus eugeniae; germination; industrial waste; macronutrient; microbial activity; nonhuman; pH; physical appearance; phytotoxicity; phytotoxicity assay; plant nutrient; Pleurotus; Pleurotus sajorcaju; priority journal; Sesbania; Sesbania sesban; soil amendment; vermicompost; animal; bovine; female; hazardous waste; industrial waste; manure; Oligochaeta; soil; Manures | English | 2021 | 2021-01 | 10.1016/j.biortech.2020.124136 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Recent advances in the biological valorization of citrus peel waste into fuels and chemicals | In the quest to reduce global food loss and waste, fruit processing wastes, particularly citrus peel waste (CPW), have emerged as a promising and sustainable option for biorefinery without competing with human foods and animal feeds. CPW is largely produced and, as recent studies suggest, has the industrial potential of biological valorization into fuels and chemicals. In this review, the promising aspects of CPW as an alternative biomass were highlighted, focusing on its low lignin content. In addition, specific technical difficulties in fermenting CPW are described, highlighting that citrus peel is high in pectin that consist of non-fermentable sugars, mainly galacturonic acid. Last, recent advances in the metabolic engineering of yeast and other microbial strains that ferment CPW-derived sugars to produce value-added products, such as ethanol and mucic acid, are summarized. For industrially viable CPW-based biorefinery, more studies are needed to improve fermentation efficiency and to diversify product profiles. | Jeong, Deokyeol; Park, Heeyoung; Jang, Byeong-Kwan; Ju, YeBin; Shin, Min Hye; Oh, Eun Joong; Lee, Eun Jung; Kim, Soo Rin | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Purdue Univ, Dept Food Sci, Smith Hall, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Sch Appl Chem Engn, Dept Chem Engn, Daegu, South Korea | Jang, Byeong Kwan/IQV-9121-2023; Kim, Soo Rin/X-2192-2019; Lee, Seung Eun/ABG-1607-2021; Jeong, Deokyeol/GLR-8021-2022 | 57191332457; 57211334915; 57220054462; 57221630545; 57208401604; 59716734900; 57239965200; 36659584200 | soorinkin@knu.ac.kr;soorinkim@knu.ac.kr; | BIORESOURCE TECHNOLOGY | BIORESOURCE TECHNOL | 0960-8524 | 1873-2976 | 323 | SCIE | AGRICULTURAL ENGINEERING;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENERGY & FUELS | 2021 | 11.889 | 3.6 | 1.15 | 2025-07-30 | 67 | 74 | Saccharomyces cerevisiae; Pectin-rich biomass; Autohydrolysis; Galacturonic acid; Meso-galactaric acid | SACCHAROMYCES-CEREVISIAE; SIMULTANEOUS SACCHARIFICATION; ETHANOL-PRODUCTION; FERMENTATION; PECTIN; FRUIT; ACIDS; BIOREFINERIES; PRETREATMENT; FEEDSTOCK | Autohydrolysis; Galacturonic acid; Meso-galactaric acid; Pectin-rich biomass; Saccharomyces cerevisiae | Chemicals; Citrus Fruits; Fuels; Galacturonic Acid; Refining; Sugars; Value Added Products; Wastes; Animals; Biomass; Citrus; Ethanol; Fermentation; Humans; Pectins; Citrus; Saccharomyces cerevisiae; Food waste; Industrial chemicals; Metabolic engineering; Refining; Sugars; acid; alcohol; bioethanol; carbohydrate; chemical compound; fuel; galacturonic acid; lignin; lignocellulose; meso galactaric acid; mucic acid; pectin; unclassified drug; Fermentable sugars; Fermentation efficiency; Fruit processing; Galacturonic acids; Industrial potentials; Low lignin contents; Technical difficulties; Value added products; biofuel; biomass; chemical compound; fermentation; lignin; waste; yeast; biofuel production; biomass; chemical composition; citrus processing waste; diet supplementation; fermentation; fungal strain; metabolic engineering; nonhuman; pH; priority journal; process design; Review; Saccharomyces cerevisiae; waste valorization; animal; Citrus; human; Citrus fruits | English | 2021 | 2021-03 | 10.1016/j.biortech.2020.124603 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | An Artificial Intelligence Algorithm-Based Smartphone Application Can Help to Monitor Cough in Real Time | Yang, M.; Kim, B.; Kim, M.; Kim, S.; Song, C.; Kang, S.; Kwon, J.; Shim, J.; Lee, S.; Kang, S.; Park, H.; Sher, M. R.; Park, H. | SMG SNU Boramae Med Ctr, Internal Med, Seoul, South Korea; Korea Univ, Internal Med, Med Ctr, Anam Hosp, Seoul, South Korea; Ewha Womans Univ, Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Internal Med, Seongnam, South Korea; Soundable Hlth Inc, San Francisco, CA USA; Kangwon Natl Univ, Sch Med, Internal Med, Chunchon, South Korea; Gachon Univ, Gil Med Ctr, Internal Med, Incheon, South Korea; Kyungpook Natl Univ, Internal Med, Daegu, South Korea; Ctr Cough, Largo, FL USA; Seoul Natl Univ, Coll Med, Internal Med, Seoul, South Korea | msyangmd@gmail.com; | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AM J RESP CRIT CARE | 1073-449X | 1535-4970 | 203 | 9 | SCIE | CRITICAL CARE MEDICINE;RESPIRATORY SYSTEM | 2021 | 30.528 | 3.8 | 0 | English | 2021 | 2021-05-01 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Antifibrotic Therapy in Fibrosing Interstitial Lung Disease: A Retrospective Analysis at a Tertiary Referral Institution | Koppurapu, V. S.; Zemkova, Y.; Barber, D.; Shin, K.; Laroia, A.; Lee, C.; Ussavarungsi, K. | Univ Iowa Hosp & Clin, Iowa City, IA 52242 USA; Kyungpook Natl Univ, Sch Med, Radiol, Daegu, South Korea; Univ Iowa Hosp & Clin, Radiol, Iowa City, IA USA | Koppurapu, Vikas/ADL-1243-2022 | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AM J RESP CRIT CARE | 1073-449X | 1535-4970 | 203 | 9 | SCIE | CRITICAL CARE MEDICINE;RESPIRATORY SYSTEM | 2021 | 30.528 | 3.8 | 0 | English | 2021 | 2021-05-01 | 바로가기 | 바로가기 |
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