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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Highly effective prussian blue-coated MXene aerogel spheres for selective removal of cesium ions | Two-dimensional titanium carbide MXene (Ti3C2Tx) incorporated with Prussian blue aerogel spheres (PBMXsphere) were designed and fabricated by a simple synthesis method for selective cesium removal in different matrices. The synthesized micro spheres exhibited unique internal structure and high porosity. They were enriched with oxygenated functional groups of Ti3C2Tx and offered selective binding sites of Prussian blue. The synthesized PBMXsphere can thus be used as a unique adsorbent for radionuclide Cs+ removal in water. Analytical techniques such as PXRD, FT-IR, FE-SEM, and XPS were utilized to investigate the material characteristics and structural changes after cesium ion adsorption. The PBMXsphere spheres unveiled an exceptional adsorption capacity of 315.91 mg/g for Cs+, which is amongst the highest values reported for similar adsorbents. PBMX-IIIsphere was capable for removing cesium ions at the ppb level with a distribution coefficient of 3.42 x 1005 mL/g in the presence of coexisting ions such as Na+, K+, Mg2+, and Ca2+. The PBMXsphere spheres were highly efficient for Cs+ removal under extreme pH values (pH 2-12). Furthermore, PBMX-IIIsphere offered exceptionally high removal efficiency in 1 M HCl and 5 M NaNO3 solution matrices. For practical applications, extraordinary Cs+ capturing behavior was observed in simulated seawater. (C) 2020 Elsevier B.V. All rights reserved. | Shahzad, Asif; Moztahida, Mokrema; Tahir, Khurram; Kim, Bolam; Jeon, Hyeji; Ghani, Ahsan Abdul; Maile, Nagesh; Jang, Jiseon; Lee, Dae Sung | Kyungpook Natl Univ, Dept Environm Engn, 80 Daehak Ro, Daegu 41566, South Korea; Korea Radioact Waste Agcy, R&D Inst Radioact Wastes, 174 Gajeong Ro, Daejeon 34129, South Korea | ; Maile, Nagesh/AFD-8838-2022; Tahir, Khurram/KFS-5321-2024 | 57190382338; 57202904382; 57207114377; 57208922438; 57218291200; 57218294089; 57193804539; 56611137400; 55568524907 | daesung@knu.ac.kr; | JOURNAL OF NUCLEAR MATERIALS | J NUCL MATER | 0022-3115 | 1873-4820 | 539 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;NUCLEAR SCIENCE & TECHNOLOGY | 2020 | 2.936 | 4.4 | 2.29 | 2025-06-25 | 53 | 56 | Titanium carbide MXene; Prussian blue; Radionuclide; Aerogel spheres | BLUE/GRAPHENE OXIDE NANOCOMPOSITES; RADIOACTIVE CESIUM; ENHANCED ADSORPTION; HYDROGEL BEADS; EFFICIENT; WATER; EXTRACTION; SEQUESTRATION; NANOSHEETS; CAPTURE | Aerogel spheres; Prussian blue; Radionuclide; Titanium carbide MXene | Aerogels; Binding sites; Cesium; Cesium compounds; Chlorine compounds; Ions; Sodium nitrate; Spheres; Titanium carbide; Adsorption capacities; Distribution coefficient; Internal structure; Material characteristics; Removal efficiencies; Selective binding; Selective removal; Simulated seawaters; Nitrogen compounds | English | 2020 | 2020-10 | 10.1016/j.jnucmat.2020.152277 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Adjustment of azathioprine dose should be based on a lower 6-TGN target level to avoid leucopenia in NUDT15 intermediate metabolizers | Background The association betweenNUDT15polymorphisms and thiopurine-induced leucopenia is well known. Aim To investigate the association betweenNUDT15polymorphisms and time-to-leucopenia in paediatric patients with inflammatory bowel disease (IBD) receiving azathioprine and to determine the relationship betweenNUDT15polymorphisms and 6-thioguanine nucleotide (6-TGN) levels. Methods This retrospective observational study included Korean paediatric patients with IBD who were treated with azathioprine and underwentNUDT15andTPMTgenotyping. Azathioprine doses were adjusted by regular thiopurine metabolite monitoring. Factors associated with time-to-leucopenia and the relationship betweenNUDT15polymorphisms and 6-TGN levels were analysed. Results Among the 167 patients included, leucopenia was observed in 16% (19/119), 44% (20/45) and 100% (3/3) of the NUDT15 normal, intermediate and poor metabolizers respectively (P < 0.001).NUDT15polymorphism was significantly associated with time-to-leucopenia (HR = 5.26, 95% CI = 2.74-10.09,P < 0.001). There was a positive association between 6-TGN levels and leucopenia among the NUDT15 intermediate/TPMT normal metabolizers (median 361.3 vs 263.8 pmol/8 x 10(8)RBC,P = 0.013). The most accurate 6-TGN cut-off level associated with leucopenia was 308.2 pmol/8 x 10(8)RBC (AUC = 0.742, 95% CI = 0.569-0.915, sensitivity 80.0%, specificity 72.7%,P < 0.001) in this subgroup. When the specificity was set to <15%, the 6-TGN cut-off level was 167.1 pmol/8 x 10(8)RBC (sensitivity 93.3%, specificity 13.6%). Conclusion NUDT15polymorphisms were associated with time-to-leucopenia during azathioprine treatment in Korean paediatric patients with IBD. In order to reduce the development of thiopurine-induced leucopenia (<15%) in NUDT15 intermediate metabolizers, adjustment of azathioprine doses should be based on a lower 6-TGN target level (<167.1 pmol/8 x 10(8)RBC). | Kang, Ben; Kim, Tae Jun; Choi, Jaeyoung; Baek, Sun-Young; Ahn, Soohyun; Choi, Rihwa; Lee, Soo-Youn; Choe, Yon Ho | Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Med, Sch Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Pediat, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Samsung Med Ctr, Stat & Data Ctr, Res Inst Future Med, Seoul, South Korea; Ajou Univ, Dept Math, Suwon, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Lab Med & Genet, Sch Med, 81 Irwon Ro, Seoul 06351, South Korea; Green Cross Labs, Dept Lab Med, Yongin, South Korea | Lee, YuRim/ITU-1407-2023; 康, 奔/JMQ-0812-2023 | 57194823199; 57189389501; 57202550087; 57203575696; 55040601100; 55821831600; 7601413957; 21333712100 | suddenbz@skku.edu;i101016@skku.edu; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 52 | 3 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 8.171 | 4.5 | 1.27 | 2025-06-25 | 18 | 18 | INFLAMMATORY-BOWEL-DISEASE; THIOPURINE S-METHYLTRANSFERASE; 6-THIOGUANINE NUCLEOTIDE LEVELS; PEDIATRIC-PATIENTS; JAPANESE PATIENTS; CROHNS-DISEASE; POLYMORPHISMS; CHILDREN; GENOTYPE; AZATHIOPRINE/6-MERCAPTOPURINE | Adolescent; Azathioprine; Child; Female; Guanine Nucleotides; Humans; Immunosuppressive Agents; Inflammatory Bowel Diseases; Leukopenia; Male; Methyltransferases; Polymorphism, Genetic; Pyrophosphatases; Thionucleotides; azathioprine; Nudix hydrolase; thioguanosine; thiopurine methyltransferase; 6-thioguanylic acid; azathioprine; guanine nucleotide; immunosuppressive agent; inorganic pyrophosphatase; methyltransferase; MTH2 protein, human; nucleotide; TPMT protein, human; adolescent; Article; child; cohort analysis; controlled study; diagnostic test accuracy study; disease course; DNA polymorphism; erythrocyte count; female; genetic association; genotype; genotyping technique; human; human cell; incidence; inflammatory bowel disease; Korean (people); leukopenia; major clinical study; male; NUDT15 gene; observational study; patient monitoring; pediatric patient; predictive value; priority journal; receiver operating characteristic; retrospective study; sensitivity and specificity; TPMT gene; blood; genetic polymorphism; genetics; leukopenia | English | 2020 | 2020-08 | 10.1111/apt.15810 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | COMPARISON OF FACE EMOTIONAL RECOGNITION DEFICITS IN REMITTED SCHIZOPHRENIA AND BIPOLAR I DISORDER | Won, Seunghee; Bae, Minjae; Jin, Bohyun; Rim, Hyo-Deog | Kyungpook Natl Univ Hosp, Daegu, South Korea | SCHIZOPHRENIA BULLETIN | SCHIZOPHRENIA BULL | 0586-7614 | 1745-1701 | 46 | SCIE;SSCI | PSYCHIATRY | 2020 | 9.306 | 4.5 | 0 | English | 2020 | 2020-04 | 바로가기 | 바로가기 | |||||||||||||||||
| ○ | ○ | Article | Evaluation of local and systemic immune responses in pigs experimentally challenged with porcine reproductive and respiratory syndrome virus | The host-associated defence system responsible for the clearance of porcine reproductive and respiratory syndrome virus (PRRSV) from infected pigs is currently poorly understood. To better understand the dynamics of host-pathogen interactions, seventy-five of 100 pigs infected with PRRSV-JA142 and 25 control pigs were euthanized at 3, 10, 21, 28 and 35 days post-challenge (dpc). Blood, lung, bronchoalveolar lavage (BAL) and bronchial lymph node (BLN) samples were collected to evaluate the cellular immune responses. The humoral responses were evaluated by measuring the levels of anti-PRRSV IgG and serum virus-neutralizing (SVN) antibodies. Consequently, the highest viral loads in the sera and lungs of the infected pigs were detected between 3 and 10 dpc, and these resulted in moderate to mild interstitial pneumonia, which resolved accompanied by the clearance of most of the virus by 28 dpc. At peak viremia, the frequencies of alveolar macrophages in infected pigs were significantly decreased, whereas the monocyte-derived DC/macrophage and conventional DC frequencies were increased, and these effects coincided with the early induction of local T-cell responses and the presence of proinflammatory cytokines/chemokines in the lungs, BAL, and BLN as early as 10 dpc. Conversely, the systemic T-cell responses measured in the peripheral blood mononuclear cells were delayed and significantly induced only after the peak viremic stage between 3 and 10 dpc. Taken together, our results suggest that activation of immune responses in the lung could be the key elements for restraining PRRSV through the early induction of T-cell responses at the sites of virus replication. | Nazki, Salik; Khatun, Amina; Jeong, Chang-Gi; Mattoo, Sameer ul Salam; Gu, Suna; Lee, Sim-In; Kim, Seung-Chai; Park, Ji-Hyo; Yang, Myoun-Sik; Kim, Bumseok; Park, Choi-Kyu; Lee, Sang-Myeong; Won-II, K. | Jeonbuk Natl Univ, Coll Vet Med, Iksan, South Korea; Sher & Bangla Agr Univ, Fac Anim Sci & Vet Med, Dept Pathol, Dhaka 1207, Bangladesh; Jeonbuk Natl Univ, Adv Inst Environm & Biosci, Div Biotechnol, Coll Environm & Biosource Sci, Iksan, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu, South Korea | ; Kim, Seung-Chai/KOZ-8882-2024; Khatun, Amina/U-7070-2017; Nazki, Salik/AAV-1882-2021; Kim, Soo-Yeon/ADR-9663-2022 | 56453296600; 57198117841; 57200101892; 59157941100; 57069485400; 57215039741; 57204020595; 57216882198; 57189872949; 7501566917; 24768064900; 36062712900; 55730056800 | leesangm@jbnu.ac.kr;kwi0621@jbnu.ac.kr; | VETERINARY RESEARCH | VET RES | 0928-4249 | 1297-9716 | 51 | 1 | SCIE | VETERINARY SCIENCES | 2020 | 3.699 | 4.5 | 1.51 | 2025-06-25 | 28 | 23 | REGULATORY T-CELLS; BIOLOGICAL CHARACTERISTICS; PROINFLAMMATORY CYTOKINES; PRRSV INFECTION; DENDRITIC CELLS; INFLUENZA-VIRUS; LYMPH-NODES; IFN-GAMMA; NK CELLS; SWINE | Adaptive Immunity; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Immunity, Innate; Lung; Lymph Nodes; Parenchymal Tissue; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; Sus scrofa; Swine; chemokine; gamma interferon; immunoglobulin A; immunoglobulin G; interleukin 10; interleukin 12; interleukin 17; interleukin 4; interleukin 6; myeloperoxidase; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; antibody response; antigen presenting cell; Article; autopsy; blood sampling; CD4+ T lymphocyte; CD8+ T lymphocyte; cell infiltration; cell viability; controlled study; enzyme linked immunosorbent assay; flow cytometry; histology; histopathology; immune response; immunosuppressive treatment; lung alveolus macrophage; lung lavage; lymphocyte proliferation; macrophage; microscopy; nonhuman; phagocytosis; porcine reproductive and respiratory syndrome; Porcine reproductive and respiratory syndrome virus; real time reverse transcription polymerase chain reaction; RNA extraction; upregulation; viremia; virus load; virus replication; adaptive immunity; animal; bronchoalveolar lavage fluid; bronchus; immunology; innate immunity; lung; lymph node; parenchyma; physiology; pig; porcine reproductive and respiratory syndrome; Porcine reproductive and respiratory syndrome virus; virology | English | 2020 | 2020-05-13 | 10.1186/s13567-020-00789-7 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Extremely low risk of hepatocellular carcinoma development in patients with chronic hepatitis B in immune-tolerant phase | Background Anti-viral therapy is not indicated for patients with chronic hepatitis B (CHB) in the immune-tolerant phase. Aims To investigate the cumulative incidence of phase change and hepatocellular carcinoma (HCC) and independent predictors for phase change in patients with CHB in immune-tolerant phase. Methods In total, 946 patients in immune-tolerant phase, defined as hepatitis B e antigen positivity, HBV-DNA >20 000 IU/mL and alanine aminotransferase (ALT) 10(7) IU/mL was associated independently with a reduced risk of phase change (hazard ratio [HR] = 0.734, P = 0.008), whereas a high ALT level, above the cut-off recommended in the Korean Association for the Study of the Liver guidelines (34 IU/L for men and 30 IU/L for women), was associated independently with a greater risk of phase change (HR = 1.885, P 10(7) IU/mL may be useful to define immune-tolerant phase. In addition, an extremely low risk of HCC development was observed in patients with CHB in immune-tolerant phase. | Lee, Han Ah; Lee, Hyun Woong; Kim, In Hee; Park, Soo Young; Sinn, Dong Hyun; Yu, Jung Hwan; Seo, Yeon Seok; Um, Soon Ho; Lee, Jung Il; Lee, Kwan Sik; Lee, Chang Hun; Tak, Won Young; Kweon, Young Oh; Kang, Wonseok; Paik, Yong-Han; Lee, Jin-Woo; Suh, Sang Jun; Jung, Young Kul; Kim, Beom Kyung; Park, Jun Yong; Kim, Do Young; Ahn, Sang Hoon; Han, Kwang-Hyub; Yim, Hyung Joon; Kim, Seung Up | Korea Univ, Coll Med, Seoul, South Korea; Yonsei Univ, Gangnam Severance Hosp, Coll Med, Seoul, South Korea; Chonbuk Natl Univ, Med Sch, Jeonju, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Sch Med, Seoul, South Korea; Inha Univ, Inha Univ Hosp, Sch Med, Incheon, South Korea; Korea Univ, Ansan Hosp, Coll Med, Ansan, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Severance Hosp, Yonsei Liver Ctr, Seoul, South Korea | ; Lee, Shin-Jae/D-5883-2012; Lee, Chang Hun/LHA-3105-2024; Ahn, Sang Hoon/AFM-2603-2022; Park, Jun/H-7127-2019; Sinn, Dong/L-3701-2019; Kim, Sun/L-4239-2013; Kim, Sun Jung/AAM-7334-2020; Kim, Jin-Seok/AAK-5424-2020; Sinn, Dong Hyun/O-5941-2014; Lee, Jeong-Hoon/Q-1055-2018; LEE, HYUN/ABC-6119-2021 | 57190980926; 55509204800; 7404143744; 57191674344; 23493891100; 57893118300; 35234912400; 7005044023; 57190744199; 7501516334; 57209941071; 7004074582; 7004694832; 19640141000; 8423833300; 57216961138; 25723856600; 25626113500; 35302925200; 47861376300; 56119929100; 7401989551; 7402963689; 7005664934; 54933821200 | ihkimmd@jbnu.ac.kr;gudwns21@korea.ac.kr;KSUKOREA@yuhs.ac; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 52 | 1 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 8.171 | 4.5 | 4.12 | 2025-06-25 | 61 | 69 | T-CELL FUNCTION; NATURAL-HISTORY; HBV DNA; CIRRHOSIS; FIBROSIS; VIRUS; ALT; GUIDELINES; LEVEL | Adult; Alanine Transaminase; Carcinoma, Hepatocellular; DNA, Viral; Female; Hepatitis B e Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immune Tolerance; Incidence; Liver Neoplasms; Male; Middle Aged; Retrospective Studies; alanine aminotransferase; hepatitis B(e) antigen; virus DNA; alanine aminotransferase; hepatitis B(e) antigen; virus DNA; adult; alanine aminotransferase blood level; Article; cancer risk; chronic hepatitis B; cohort analysis; disease course; female; human; incidence; liver cell carcinoma; low risk population; major clinical study; male; practice guideline; priority journal; retrospective study; risk factor; risk reduction; blood; chronic hepatitis B; clinical trial; complication; genetics; Hepatitis B virus; immunological tolerance; immunology; liver cell carcinoma; liver tumor; middle aged; multicenter study; virology | English | 2020 | 2020-07 | 10.1111/apt.15741 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Integrated time-serial transcriptome networks reveal common innate and tissue-specific adaptive immune responses to PRRSV infection | Porcine reproductive and respiratory syndrome virus (PRRSV) infection is the most important viral disease causing severe economic losses in the swine industry. However, mechanisms underlying gene expression control in immunity-responsible tissues at different time points during PRRSV infection are poorly understood. We constructed an integrated gene co-expression network and identified tissue- and time-dependent biological mechanisms of PRRSV infection through bioinformatics analysis using three tissues (lungs, bronchial lymph nodes [BLNs], and tonsils) via RNA-Seq. Three groups with specific expression patterns (i.e., the 3-dpi, lung, and BLN groups) were discovered. The 3 dpi-specific group showed antiviral and innate-immune signalling similar to the case for influenza A infection. Moreover, we observed adaptive immune responses in the lung-specific group based on various cytokines, while the BLN-specific group showed down-regulated AMPK signalling related to viral replication. Our study may provide comprehensive insights into PRRSV infection, as well as useful information for vaccine development. | Lim, Byeonghwi; Kim, Sangwook; Lim, Kyu-Sang; Jeong, Chang-Gi; Kim, Seung-Chai; Lee, Sang-Myeong; Park, Choi-Kyu; te Pas, Marinus F. W.; Gho, Haesu; Kim, Tae-Hun; Lee, Kyung-Tai; Kim, Won-Il; Kim, Jun-Mo | Chung Ang Univ, Dept Anim Sci & Technol, Anseong 17546, Gyeonggi Do, South Korea; Iowa State Univ, Dept Anim Sci, Ames, IA 50011 USA; Jeonbuk Natl Univ, Coll Vet Med, Iksan 54596, Jeollabuk Do, South Korea; Chungbuk Natl Univ, Coll Vet Med, Cheongju 28644, Chungcheongbuk, South Korea; Kyungpook Natl Univ, Coll Vet Med, Daegu 41566, South Korea; Kyungpook Natl Univ, Anim Dis Intervent Ctr, Daegu 41566, South Korea; Wageningen UR Livestock Res, Wageningen, Netherlands; Natl Inst Anim Sci, RDA, Anim Genom & Bioinformat Div, Wonju 55365, South Korea | ; Kim, Seung-Chai/KOZ-8882-2024; Kim, Tae Hun/IXD-3897-2023; Lim, Kyu-Sang/ABE-8516-2020; Kim, Sang-Hyun/J-5402-2012 | 57200099959; 57212300945; 35795941400; 57200101892; 57204020595; 36062712900; 24768064900; 7003974318; 57219463079; 57056659000; 57217153097; 55730056800; 57197706730 | leekt@korea.kr;kwi0621@jbnu.ac.kr;junmokim@cau.ac.kr; | VETERINARY RESEARCH | VET RES | 0928-4249 | 1297-9716 | 51 | 1 | SCIE | VETERINARY SCIENCES | 2020 | 3.699 | 4.5 | 1.43 | 2025-06-25 | 22 | 21 | adaptive immunity; gene co-expression network; innate immunity; integrated transcriptomes; porcine reproductive and respiratory syndrome virus | RESPIRATORY SYNDROME VIRUS; RIG-I; DIFFERENTIAL EXPRESSION; NONSTRUCTURAL PROTEINS; LYMPHOID ORGANS; INTERFERON; PIGS; REPLICATION; ACTIVATION; ALPHA | adaptive immunity; gene co-expression network; innate immunity; integrated transcriptomes; porcine reproductive and respiratory syndrome virus | Adaptive Immunity; Animals; Immunity, Innate; Porcine Reproductive and Respiratory Syndrome; Porcine respiratory and reproductive syndrome virus; Sus scrofa; Swine; Transcriptome; beta1 interferon; CD134 antigen; CD70 antigen; chemokine receptor CCR3; chemokine receptor CXCR3; complementary DNA; decoy receptor 3; gamma interferon inducible protein 10; high mobility group B1 protein; interferon induced helicase C domain containing protein 1; interferon regulatory factor 1; interferon regulatory factor 3; interferon regulatory factor 4; interferon regulatory factor 7; interleukin 20; interleukin 26; interleukin 6; Janus kinase 1; macrophage inflammatory protein 3alpha; osteoclast differentiation factor; promyelocytic leukemia protein; protein kinase TYK2; RANTES; retinoic acid inducible protein I; ribonuclease L; STAT1 protein; STAT2 protein; suppressor of cytokine signaling 1; transcription factor RelA; transcriptome; tumor necrosis factor receptor superfamily member 9; transcriptome; adaptive immunity; AMPK signaling; animal cell; animal model; animal tissue; Article; bioinformatics; controlled study; enzyme linked immunosorbent assay; false discovery rate; gene control; gene expression; gene regulatory network; ID50 (median infectious dose); immune response; immunofluorescence; influenza A; lymph node; MARC-145 cell line; microtiter plate assay; multidimensional scaling; nonhuman; porcine reproductive and respiratory syndrome; Porcine reproductive and respiratory syndrome virus; protein protein interaction; RNA extraction; RNA sequence; virus load; virus replication; adaptive immunity; animal; genetics; immunology; innate immunity; physiology; pig; porcine reproductive and respiratory syndrome; Porcine reproductive and respiratory syndrome virus; virology | English | 2020 | 2020-10-13 | 10.1186/s13567-020-00850-5 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome againstStreptococcus equisubsp.equiin foals | Cefquinome is administered in horses for the treatment of respiratory infection caused byStreptococcus equisubsp.zooepidemicus, and septicemia caused byEscherichia coli. However, there have been no attempts to use cefquinome againstStreptococcus equisubsp. equi(S. equi), the causative agent of strangles. Hence the objective of this study was to calculate an optimal dosage of cefquinome againstS. equibased on pharmacokinetics and pharmacodynamics integration. Cefquinome (1.0 mg/kg) was administered by intravenous and intramuscular routes to six healthy thoroughbred foals. Serum cefquinome concentrations were determined by high-performance liquid chromatography. The in vitro and ex vivo antibacterial activity were determined from minimum inhibitory concentrations (MIC) and bacterial killing curves. The optimal dosage was calculated from the integration of pharmacokinetic parameters and area under the curve (AUC(24h)/MIC) values. Total body clearance and volume of distribution of cefquinome after intravenous administration were 0.06 L/h/kg and 0.09 L/kg, respectively. Following intramuscular administration, a maximum concentration of 0.73 mu g/mL at 1.52 h (T-max) and a systemic bioavailability of 37.45% were observed. The MIC of cefquinome againstS. equiwas 0.016 mu g/mL. The ex vivo AUC(24h)/MIC values representing bacteriostatic, and bactericidal activity were 113.11, and 143.14 h, respectively. Whereas the %T > MIC for bactericidal activity was 153.34%. In conclusion, based on AUC(24h)/MIC values and pharmacokinetic parameters, cefquinome when administered by intramuscularly at a dosage of 0.53 mg/kg every 24 h, would be effective against infection caused byS. equiin foals. Further studies may be necessary to confirm its therapeutic efficacy in a clinical environment. | Lee, Dong-Ha; Birhanu, Biruk Tesfaye; Lee, Eon-Bee; Lee, Seung-Jin; Boby, Naila; Park, Yong-Soo; Park, Seung-Chun | Kyungpook Natl Univ, Coll Vet Med, Lab Vet Pharmacokinet & Pharmacodynam, Bukgu 41566, Daegu, South Korea; Korean Inst Toxicol, Dev & Reprod Toxicol Res Grp, Daejeon 34114, South Korea; Korea Natl Coll Agr & Fisheries, Dept Equine Ind, Jeonju 54874, South Korea | Birhanu, Biruk/F-1622-2017; Park, Seung-Chun/AAV-3388-2021; Lee, Jun Young/CAI-2335-2022; Boby, Naila/GRE-8096-2022; Lee, Jung Bok/HHZ-3200-2022; Park, Yong-Soo/AAR-8033-2021 | 57219472699; 56996190000; 57216526135; 58689440900; 57197787296; 57141113000; 7501832396 | parksch@knu.ac.kr; | VETERINARY RESEARCH | VET RES | 0928-4249 | 1297-9716 | 51 | 1 | SCIE | VETERINARY SCIENCES | 2020 | 3.699 | 4.5 | 0.56 | 2025-06-25 | 9 | 9 | cefquinome; Streptococcus equisubsp; equi; antibacterial activity; PK; PD integration; optimal dosage | IN-VITRO ACTIVITY; CEFTIOFUR; BIOAVAILABILITY; DESFUROYLCEFTIOFUR; PLASMA; COWS | antibacterial activity; cefquinome; optimal dosage; PK/PD integration; Streptococcus equi subsp. equi | Animals; Anti-Bacterial Agents; Cephalosporins; Horse Diseases; Horses; Injections, Intramuscular; Microbial Sensitivity Tests; Streptococcal Infections; Streptococcus; acetonitrile; cefquinome; trifluoroacetic acid; antiinfective agent; cefquinome; cephalosporin derivative; absorption rate constant; accuracy; antibacterial activity; area under the curve; Article; bacterial count; bactericidal activity; bacteriostatic activity; bioavailability; blood sampling; drug distribution; EC50; elimination rate constant; Escherichia coli; heart rate; high performance liquid chromatography; horse; limit of detection; limit of quantitation; maximum concentration; maximum plasma concentration; minimum inhibitory concentration; nonhuman; pharmacodynamics; pharmacokinetic parameters; physical examination; protein binding; rectal temperature; Rhodococcus hoagii; simulation; Streptococcus equi; time to maximum plasma concentration; volume of distribution; animal; drug effect; horse disease; intramuscular drug administration; microbial sensitivity test; Streptococcus; Streptococcus infection; veterinary medicine | English | 2020 | 2020-10-15 | 10.1186/s13567-020-00853-2 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Article | Randomised clinical trial: tegoprazan, a novel potassium-competitive acid blocker, or lansoprazole in the treatment of gastric ulcer | Background Tegoprazan is a novel potassium-competitive acid blocker for the treatment of acid-related disorders. Aims To assess whether tegoprazan is non-inferior to lansoprazole in terms of efficacy and safety in patients with gastric ulcers. Methods In this phase 3, double-blind, active control, multicentre study, 306 gastric ulcer patients were randomised to one of three treatment groups: tegoprazan 50 mg, tegoprazan 100 mg and lansoprazole 30 mg once daily for 4 or 8 weeks.The primary endpoint was the cumulative percentages of patients with healed ulcers confirmed by endoscopy up to 8 weeks from treatment initiation. Symptoms and safety were assessed. Results In the full analysis set, the cumulative healing rates at week 8 were 94.8% (91/96) for the tegoprazan 50 mg, 95.0% (94/99) for the tegoprazan 100 mg and 95.7% (89/93) for the lansoprazole 30 mg groups. At week 4, the respective healing rates were 90.6% (87/96), 91.9% (91/99), and 89.2% (83/93). In per protocol analysis, 4-week healing rates were 95.4% (84/88), 94.6% (88/93) and 92.9% (79/85) for tegoprazan 50 mg, tegoprazan 100 mg and lansoprazole 30 mg, respectively. Both doses of tegoprazan were non-inferior to lansoprazole in ulcer healing at 4 and 8 weeks. The incidence of drug-related treatment-emergent adverse events did not differ among groups. The increase in serum gastrin concentration was not higher in tegoprazan-treated patients than in lansoprazole-treated patients. Conclusions Tegoprazan 50 or 100 mg were not inferior to lansoprazole 30 mg once daily in the treatment of gastric ulcers. | Cho, Yu Kyung; Choi, Myung-Gyu; Choi, Suck Chei; Lee, Kee Myung; Kim, Tae Oh; Park, Soo-Heon; Moon, Jeong Seop; Lim, Yun Jeong; Kang, Dae Hwan; Cheon, Gab Jin; Baik, Gwang Ho; Kim, Kyoung Oh; Cho, Kwang Bum; Jang, Jin Seok; Park, Jong-Jae; Son, Byoung Kwan; Jung, Hye-Kyung; Kim, Byung-Wook; Kim, Sung Kuk; Lee, Soo Teik; Cha, Jae Myung; Kim, Ah Rong; Kim, Eun Ji; Park, Hyun Wook; Song, Geun Seog | Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Catholic Photomed Res Inst, Seoul, South Korea; Wonkwang Univ Hosp, Iksan, South Korea; Ajou Univ, Ajou Univ Hosp, Sch Med, Suwon, South Korea; Inje Univ, Haeundae Paik Hosp, Sch Med, Busan, South Korea; Catholic Univ Korea, Yeouido St Marys Hosp, Coll Med, Seoul, South Korea; Inje Univ, Seoul Paik Hosp, Coll Med, Seoul, South Korea; Dongguk Univ, Coll Med, Ilsan Hosp, Goyang, South Korea; Pusan Natl Univ, Sch Med, Yangsan Hosp, Yangsan, South Korea; Ulsan Univ, Gangneung Asan Hosp, Coll Med, Kangnung, South Korea; Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea; Gachon Univ, Sch Med, Gil Med Ctr, Incheon, South Korea; Keimyung Univ, Sch Med, Daegu, South Korea; Dong A Univ, Coll Med, Busan, South Korea; Korea Univ, Coll Med, Seoul, South Korea; Eulji Univ Hosp, Seoul, South Korea; Ewha Womans Univ, Mokdong Hosp, Seoul, South Korea; Catholic Univ Korea, Incheon St Marys Hosp, Coll Med, Incheon, South Korea; Kyungpook Univ, Sch Med, Daegu, South Korea; Chonbuk Natl Univ, Med Sch, Jeonju, South Korea; Kyung Hee Univ, KyungHee Univ Hosp Gangdong, Sch Med, Seoul, South Korea; HK Inno N Corp, Clin Dev Div, Seoul, South Korea | Park, Heeyoung/HJZ-0608-2023; Choi, Myung-Gyu/D-6079-2014; Kim, Hyung/J-5451-2012; Cheon, Jung-Eun/J-5684-2012; Kang, Dae/A-4703-2011; Kim, Yuriy/ABD-7016-2020; Lee, Si/ABH-1408-2020; Cheon, Jae/B-4523-2015 | choim@catholic.ac.kr; | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | ALIMENT PHARM THER | 0269-2813 | 1365-2036 | 52 | 5 | SCIE | GASTROENTEROLOGY & HEPATOLOGY;PHARMACOLOGY & PHARMACY | 2020 | 8.171 | 4.5 | 51 | GASTROESOPHAGEAL-REFLUX; VS. LANSOPRAZOLE; VONOPRAZAN; SECRETION; EFFICACY | English | 2020 | 2020-09 | 10.1111/apt.15865 | 바로가기 | 바로가기 | 바로가기 | ||||||||||
| ○ | ○ | Article | Identification of secondary metabolites in Averrhoa carambola L. bark by high-resolution mass spectrometry and evaluation for α-glucosidase, tyrosinase, elastase, and antioxidant potential | In this study, paper spray ionization (PSI) coupled to high-resolution mass spectrometry has been used to identify secondary metabolites from ethanol extracts of Averrhoa carambola L. bark (ABE). Various phytoconstituents including phenolic acids, flavonoids, xanthones and terpenoids were identified from the bark. ABE shows potential antioxidant activity as well as markedly inhibited alpha-glucosidase, elastase, and tyrosinase enzyme activities in a concentration-dependent fashion, respectively. ABE significantly inhibited alpha-glucosidase at lower concentration (IC50: 7.15 +/- 0.06 mu g/mL). Identified compounds were tested to understand the biological activity of ABE. Experimental results suggest that norathyriol, one of the identified compounds, has significant alpha-glucosidase (IC50: 0.81 +/- 0.01 mu g/mL) inhibition and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities (IC50: 4.90 +/- 0.09 mu g/mL). At a dose of 100 mg/kg, ABE significantly decreased the postprandial blood glucose level in oral glucose tolerance test (OGTT). This study shows that carambola bark can be a potential source of bioactive compounds. | Islam, Syful; Alam, Md Badrul; Ahmed, Arif; Lee, Seulgidaun; Lee, Sang-Han; Kim, Sunghwan | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Munshiganj Dist Off, Dept Environm, Munshiganj 1500, Bangladesh; Kyungpook Natl Univ, Dept Food Sci & Biotechnol, Daegu 41566, South Korea; Mass Spectrometry Converging Res Ctr, Daegu 41566, South Korea; Green Nano Mat Res Ctr, Daegu 41566, South Korea | Ahmed, Arif/K-6456-2019; Alam, Md Badrul/AAK-7176-2021; Islam, Syful/AAZ-5084-2021; Kim, Sunghwan/HKN-9812-2023; Lee, Seung Eun/ABG-1607-2021 | 57213340400; 56706777100; 55758288700; 57200370629; 57221453703; 57203772967 | sang@knu.ac.kr;sunghwank@knu.ac.kr; | FOOD CHEMISTRY | FOOD CHEM | 0308-8146 | 1873-7072 | 332 | SCIE | CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2020 | 7.514 | 4.6 | 1.65 | 2025-06-25 | 27 | 34 | Averrhoa carambola; Paper spray ionization (PSI); Bioactive compounds; Anti-oxidant; alpha-glucosidase | PAPER SPRAY IONIZATION; GALLIC ACID; POLYPHENOLS; CAPACITY; SPECTRA; POMACE; MS | Anti-oxidant; Averrhoa carambola; Bioactive compounds; Paper spray ionization (PSI); α-glucosidase | alpha-Glucosidases; Antioxidants; Averrhoa; Mass Spectrometry; Metabolomics; Monophenol Monooxygenase; Pancreatic Elastase; Antioxidants; Bioactivity; Drug products; Glucose; Mass spectrometry; Plants (botany); alpha glucosidase inhibitor; antidiabetic agent; antioxidant; Averrhoa carambola extract; betaine; carnitine; choline; cinnamic acid; coriolic acid; drug metabolite; elastase inhibitor; epicatechin; epigallocatechin; gallic acid; gingerol; glucose; norathyriol; oxygenase inhibitor; proline; protocatechuic acid; quinic acid; rosiglitazone; salicylic acid; salicylic acid methyl ester; sorbitol; sucrose; syringic acid; terpenoid; unclassified drug; unindexed drug; vanillic acid; alpha glucosidase; antioxidant; monophenol monooxygenase; pancreatic elastase; 1 ,1Diphenyl-2-picrylhydrazyl (DPPH) radicals; Anti-oxidant activities; Antioxidant potential; Blood glucose level; Concentration-dependent; High resolution mass spectrometry; Oral glucose tolerance tests; Secondary metabolites; animal experiment; animal model; antidiabetic activity; antioxidant activity; Article; bark; biological activity; controlled study; diabetes mellitus; DPPH radical scavenging assay; drug megadose; electrospray mass spectrometry; enzyme activity; enzyme inhibition; glucose blood level; glucose homeostasis; IC50; in vitro study; low drug dose; male; mouse; nonhuman; oral glucose tolerance test; paper spray ionization mass spectrometry; streptozotocin-induced diabetes mellitus; tandem mass spectrometry; Averrhoa; mass spectrometry; metabolism; metabolomics; procedures; Metabolites | English | 2020 | 2020-12-01 | 10.1016/j.foodchem.2020.127377 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Influence of drought stress on bioactive compounds, antioxidant enzymes and glucosinolate contents of Chinese cabbage (Brassica rapa) | This study investigated the effects of drought stress on Chinese cabbage (Chcab) by measuring plant growth responses, total antioxidant enzyme activities, the contents of bioactive compounds including glucosinolates (GLS, aliphatic and indolic), and binding with human serum albumin (HSA). Forty-day-old Chinese cabbage (Brassica rapa L. ssp. pekinensis) seedlings were transplanted into pots and maintained for three weeks at 10% (drought-treated, D-T) and 30% (control, C) soil water. The total leaf number, leaf area, and fresh and dry weights were significantly lower in D-T Chcab than in controls. Total GLSs and catalase activities were found to be significantly higher in D-T Chcab than in controls. Indolic GLSs were significantly higher than aliphatic GLSs in D-T Chcab. These results show that D-T Chcab reduced growth parameters and binding properties with HSA and influenced total contents of GLSs, polyphenols, flavonoids, total antioxidant enzyme activities, catalase and peroxidase. | Shawon, Rayhan Ahmed; Kang, Baek Song; Lee, Sang Gyu; Kim, Sung Kyeom; Lee, Hee Ju; Katrich, Elena; Gorinstein, Shela; Ku, Yang Gyu | Wonkwang Univ, Dept Hort Ind, Iksan 54538, South Korea; RDA, Div Smart Dev, Dept Agr Engn, NAAS, Jeonju 54875, South Korea; Kyungpook Natl Univ, Dept Hort Sci, Daegu 41566, South Korea; RDA, Vegetable Res Div, Natl Inst Hort & Herbal Sci, Wonju 55365, South Korea; Hebrew Univ Jerusalem, Sch Pharm, Hadassah Med Sch, Inst Drug Res, IL-9112001 Jerusalem, Israel | Gorinstein, Shela/K-7753-2019; Kim, Sung Kyeom/AAD-9230-2019 | 57211437330; 57210635396; 50262307100; 50262290200; 57211437441; 6603260065; 7006920311; 57213946873 | shela.gorin@mail.huji.ac.il;ygku35@wku.ac.kr; | FOOD CHEMISTRY | FOOD CHEM | 0308-8146 | 1873-7072 | 308 | SCIE | CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY;NUTRITION & DIETETICS | 2020 | 7.514 | 4.6 | 3.58 | 2025-06-25 | 78 | 81 | Chinese cabbage; Aliphatic GLS; Indolic GLS; Polyphenols; Flavonoids; Enzymes; Antioxidant capacity; Binding properties | ASCORBATE PEROXIDASE; ABIOTIC STRESS; LEAVES; PLANTS; L.; FLUORESCENCE; RESPONSES; SALINITY; CAPACITY; QUALITY | Aliphatic GLS; Antioxidant capacity; Binding properties; Caffeic acid (PubChem CID 689043); Chinese cabbage; Enzymes; Ferulic acid (PubChem CID 445858); Flavonoids; Indolic GLS; p-coumaric acid (PubChem CID 637542); Polyphenols; sinapic acid (PubChem CID 637775) | Antioxidants; Brassica rapa; Droughts; Flavonoids; Glucosinolates; Polyphenols; Seedlings; Stress, Physiological; Antioxidants; Binding energy; Drought; Flavonoids; Soil moisture; aliphatic compound; antioxidant; catalase; dihydrotachysterol; flavonoid; glucosinolate; human serum albumin; peroxidase; phenol derivative; polyphenol derivative; soil water; glucosinolate; polyphenol; Aliphatic GLS; Antioxidant capacity; Binding properties; Chinese cabbage; Indolic GLS; Polyphenols; Pubchem; Article; Brassica rapa; controlled study; drought stress; dry weight; enzyme activity; enzyme analysis; fluorometry; leaf area; nonhuman; plant growth; plant leaf; seedling; soil water content; Brassica rapa; drought; metabolism; physiological stress; Enzymes | English | 2020 | 2020-03-05 | 10.1016/j.foodchem.2019.125657 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Laser-directed synthesis of strain-induced crumpled MoS2 structure for enhanced triboelectrification toward haptic sensors | Two-dimensional (2D) transition metal dichalcogenide (TMDC) nanomaterials are currently regarded as next generation electronic materials for future flexible, transparent, and wearable electronics. Due to the lack of compatible synthesis and study, however, the characteristic influences of 2D TMDC nanomaterials have been little investigated in the field of triboelectric nanogenerator (TENG) devices that are currently one of the main technologies for mechanical energy harvesting. In this report, we demonstrate a fast, non-vacuum, wafer-scale, and patternable synthesis method for 2D MoS2 using pulsed laser-directed thermolysis. The laser-based synthesis technique that we have developed can apply internal stress to MoS2 crystal by adjusting its morphological structure, so that a surface-crumpled MoS2 TENG device generates-40% more power than a flat MoS2 one. Compared to other MoS2-based TENG devices, it shows high-performance energy harvesting (up to-25 V and-1.2 mu A) without assistance from other materials, even when the counterpart triboelectric surface has a slightly different triboelectric series. This enhanced triboelectrification is attribute to work function change as well as enlarged surface roughness. Finally, the direct-synthesized MoS2 patterns are utilized to fabricate a self-powered flexible haptic sensor array. The technique we propose here is intended to stimulate further investigation of the triboelectric effects and applications of 2D TMDC nanomaterials. | Park, Seoungwoong; Park, Jiseul; Kim, Yeon-gyu; Bae, Sukang; Kim, Tae-Wook; Park, Kwi-Il; Hong, Byung Hee; Jeong, Chang Kyu; Lee, Seoung-Ki | Seoul Natl Univ, Dept Chem, Seoul 08826, South Korea; Korea Inst Sci & Technol KIST, Inst Adv Composite Mat, Wonju 55324, Jeonbuk, South Korea; Jeonbuk Natl Univ, Div Adv Mat Engn, Jeonju 54896, Jeonbuk, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Jeonbuk Natl Univ, Dept Flexible & Printable Elect, Jeonju 54896, Jeonbuk, South Korea; Seoul Natl Univ, Adv Inst Convergence Technol, Graphene Res Ctr, Suwon 16229, Gyeonggi, South Korea; Jeonbuk Natl Univ, Dept Energy Storage Convers Engn, Hydrogen & Fuel Cell Res Ctr, Jeonju 54896, Jeonbuk, South Korea | ; Park, Kwiil/LKN-9445-2024; Kim, Hyeong-U/AAV-2668-2021; Bae, Sukang/JXN-7132-2024; Jeong, Chang Kyu/ADT-8127-2022; Hong, Byung/J-4464-2013 | 57192876196; 57467697800; 57196173366; 35727448800; 55696536800; 35280874200; 35484104700; 55961876600; 55941478300 | ckyu@jbnu.ac.kr;sklee85@kist.re.kr; | NANO ENERGY | NANO ENERGY | 2211-2855 | 2211-3282 | 78 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 17.881 | 4.6 | 3.69 | 2025-06-25 | 94 | 90 | Molybdenum disulfide; Laser synthesis; Triboelectric nanogenerator; 2D surface morphology; Self-powered haptic sensor | NANOGENERATOR; GRAPHENE; LAYER; PERFORMANCE; INTERFACE; PIEZORESPONSE; MODULATION; GENERATION; STRESS; GROWTH | 2D surface morphology; Laser synthesis; Molybdenum disulfide; Self-powered haptic sensor; Triboelectric nanogenerator | Crystal structure; Energy harvesting; Flexible electronics; Layered semiconductors; Molybdenum compounds; Nanogenerators; Nanostructured materials; Strain; Surface roughness; Transition metals; Electronic materials; Morphological structures; Synthesis techniques; Transition metal dichalcogenides; Tribo-electric series; Triboelectrification; Two Dimensional (2 D); Work function change; Pulsed lasers | English | 2020 | 2020-12 | 10.1016/j.nanoen.2020.105266 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Semimetallic features in thermoelectric transport properties of 2H-3R phase niobium diselenide | In two-dimensional van der Waals crystals, the interlayer stacking sequence often leads to a change in crystal symmetry and, thus, new polymorphs, leading to an abundant array of physical properties. In this paper, we report the polymorphic form of 2H-3R-NbSe2 that exhibits a substantial difference in terms of the gate dependence of semimetallic behavior and Seebeck coefficient, compared to the well-known 2H-NbSe2 with metallic transport behavior. The semimetallic features of 2H-3R-NbSe2 indicate the presence of minor carriers, confirmed through theoretical calculations, which is in good agreement with the transport behavior. Our results reveal perspectives for understanding the metastable 2H-3R phase NbSe2, which is not far from equilibrium, and for engineering the materials necessary for efficient energy harvesting. | Moon, Hongjae; Kim, Jeongmin; Bang, Joonho; Hong, Seokkyoon; Youn, Seonhye; Shin, Hyunjun; Roh, Jong Wook; Shim, Wooyoung; Lee, Wooyoung | Yonsei Univ, Dept Mat Sci & Engn, 50 Yonsei Ro, Seoul 03722, South Korea; DGIST, Div Nanotechnol, 333 Techno Jungang Daero, Daegu 42988, South Korea; Sungkyunkwan Univ, Dept Energy Sci, Suwon 16419, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Gyeongsangbuk Do 37224, South Korea | Bang, Joonho/AFZ-9712-2022; Shin, Hyunjun/T-4193-2018 | 57193670680; 57203325094; 56168055600; 59282029500; 57218557480; 57204817034; 25638796100; 35894501400; 55498383000 | wooyoung@yonsei.ac.kr; | NANO ENERGY | NANO ENERGY | 2211-2855 | 2211-3282 | 78 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 17.881 | 4.6 | 0.23 | 2025-06-25 | 9 | 8 | Polymorph; Niobium diselenide; Electrical conductivity; Seebeck coefficient; Thermoelectricity; Energy harvesting | Electrical conductivity; Energy harvesting; Niobium diselenide; Polymorph; Seebeck coefficient; Thermoelectricity | Energy harvesting; Niobium compounds; Selenium compounds; Van der Waals forces; Gate dependence; Interlayer stacking; Metallic transport; Polymorphic forms; Theoretical calculations; Thermoelectric transport properties; Transport behavior; Van der waals; Crystal symmetry | English | 2020 | 2020-12 | 10.1016/j.nanoen.2020.105197 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synchronized enhancement of thermoelectric properties of higher manganese silicide by introducing Fe and Co nanoparticles | Introduction of nanophases is known to be effective in improving thermoelectric performance as it allows the simultaneous engineering of electronic and thermal transports. In this study, we synthesized Fe and Co nanoparticle-embedded MnSi1.787Al0.01 nanocomposites through a simple nanometal-decoration technique and spark plasma sintering. The nanoparticles introduced in the matrix caused energy band bending at the matrix-nanoparticle interface, which induced charge transfer and energy filtering effects. These two seemingly opposing effects were combined so as to increase the power factor of the nanocomposites by enhancing the electronic transport. Moreover, we found that the lattice thermal conductivity decreased owing to intensified phonon scattering. Hence, a maximum ZT of 0.53 (at 773 K) was achieved in 0.6 vol% Fe nanoparticle-embedded nanocomposites, which is 25% higher than that of the pristine sample. | Kim, Gwansik; Kim, Hyun-Sik; Lee, Ho Seong; Kim, Jeongmin; Lee, Kyu Hyoung; Roh, Jong Wook; Lee, Wooyoung | Yonsei Univ, Dept Mat Sci & Engn, Seoul 03722, South Korea; Hongik Univ, Dept Mat Sci & Engn, Seoul 04066, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; DGIST, 333 Techno Jungang Daero, Dalseong Gun 42988, Daegu, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, Gyeongsangbuk Do 37224, South Korea | Lee, JongGu/B-7384-2013; Kim, Sung/A-4747-2013 | 57143208300; 56526077500; 55706810400; 57203325094; 35205856800; 25638796100; 55498383000 | jw.roh@knu.ac.kr;wooyoung@yonsei.ac.kr; | NANO ENERGY | NANO ENERGY | 2211-2855 | 2211-3282 | 72 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED | 2020 | 17.881 | 4.6 | 1.25 | 2025-06-25 | 33 | 32 | Nanocomposite; Thermoelectric; Higher manganese silicide; Nanometal decoration; Energy filtering effect | THERMAL-CONDUCTIVITY; MNSI-GAMMA; PERFORMANCE; TRANSPORT; FIGURE; MERIT | Energy filtering effect; Higher manganese silicide; Nanocomposite; Nanometal decoration; Thermoelectric | Charge transfer; Manganese; Manganese compounds; Nanocomposites; Nanometals; Nanoparticles; Silicides; Spark plasma sintering; Thermal conductivity; Thermal Engineering; Thermoelectricity; Electronic and thermal transports; Energy filtering; Higher manganese silicides; Lattice thermal conductivity; Nanometal decorations; Thermoelectric; Thermoelectric performance; Thermoelectric properties; Synthesis (chemical) | English | 2020 | 2020-06 | 10.1016/j.nanoen.2020.104698 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Concrete crack detection and quantification using deep learning and structured light | Considering the deterioration of civil infrastructures, the evaluation of structural safety by detecting cracks is becoming increasingly essential. In this paper, the advanced technologies of deep learning and structured light composed of vision and two laser sensors have been applied to detect and quantify cracks on surfaces of concrete structures. The YOLO (You Only Look Once) algorithm has been used for real-time detection, and the sizes of the detected cracks have been calculated based on the positions of the projected laser beams on the structural surface. Since laser beams may not be projected in parallel due to installation or manufacturing errors, the laser alignment correction algorithm with a specially designed jig module and a distance sensor is applied to increase the accuracy of the size measurement. The performance of the algorithm has been verified through simulations and experimental tests, and the results show that the cracks on the structural surfaces can be detected and quantified with high accuracy in real-time. (C) 2020 Elsevier Ltd. All rights reserved. | Park, Song Ee; Eem, Seung-Hyun; Jeon, Haemin | Hanbat Natl Univ, Dept Civil & Environm Engn, Daejeon 34158, South Korea; Kyungpook Natl Univ, Sch Convergence & Fus Syst Engn, Sangju 37224, South Korea | ; Eem, Seunghyun/KVB-1493-2024 | 57216484547; 52363442900; 35111510200 | hjeon@hanbat.ac.kr; | CONSTRUCTION AND BUILDING MATERIALS | CONSTR BUILD MATER | 0950-0618 | 1879-0526 | 252 | SCIE | CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;MATERIALS SCIENCE, MULTIDISCIPLINARY | 2020 | 6.141 | 4.7 | 6.35 | 2025-06-25 | 157 | 182 | Structural health monitoring; Crack; Detection; Quantification; Deep leaning; Structured light | IMPULSE-RESPONSE | Crack; Deep leaning; Detection; Quantification; Structural health monitoring; Structured light | Crack detection; Deep learning; Deterioration; Laser beams; Advanced technology; Civil infrastructures; Correction algorithms; Detection and quantifications; Manufacturing errors; Real-time detection; Size measurements; Structural surfaces; Concretes | English | 2020 | 2020-08-20 | 10.1016/j.conbuildmat.2020.119096 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Development of elastin-like polypeptide for targeted specific gene delivery in vivo | Background The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appears as most efficient approaches for gene delivery but often compromised in terms of biocompatibility, patient safety and high cost scale up process. Here we describe a novel platform of gene delivery by elastin-like polypeptide (ELP) based targeting biopolymers. Results For better tumor targeting and membrane penetrating characteristics, we designed various chimeric ELP-based carriers containing a cell penetrating peptide (Tat), single or multiple copies of AP1 an IL-4 receptor targeting peptide along with coding sequence of ELP and referred as Tat-A(1)E(28) or Tat-A(4)V(48). These targeted polypeptides were further analyzed for its ability to deliver siRNA (Luciferase gene) in tumor cells in comparison with non-targeted controls (Tat-E-28 or E-28). The positively charged amino acids of these polypeptides enabled them to readily complex with negatively charged nucleic acids. The complexation of nucleic acid with respective polypeptides facilitated its transfection efficiency as well as stability. The targeted polypeptides (Tat-A(1)E(28) or Tat-A(4)V(48)) selectively delivered siRNA into tumor cells in a receptor-specific fashion, achieved endosomal and lysosomal escape, and released gene into cytosol. The target specific delivery of siRNA by Tat-A(1)E(28) or Tat-A(4)V(48) was further validated in murine breast carcinoma 4T1 allograft mice model. Conclusion The designed delivery systems efficiently delivered siRNA to the target site of action thereby inducing significant gene silencing activity. The study shows Tat and AP1 functionalized ELPs constitute a novel gene delivery system with potential therapeutic applications. | Yi, Aena; Sim, Dahye; Lee, Young-Jin; Sarangthem, Vijaya; Park, Rang-Woon | Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu 41944, South Korea; All India Inst Med Sci, Dept Pathol, New Delhi 110029, India | ; Sarangthem, Vijaya/AAX-7421-2020 | 57201005875; 57213821708; 57191967618; 56001741200; 7401895636 | devi1703@gmail.com;nwpark@knu.ac.kr; | JOURNAL OF NANOBIOTECHNOLOGY | J NANOBIOTECHNOL | 1477-3155 | 18 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 10.435 | 4.7 | 2.55 | 2025-06-25 | 45 | 43 | Gene delivery; AP1-ELPs; Tumor targeting; IL-4 receptor; ELP; Cell penetrating peptide | RNA INTERFERENCE; MOLECULAR-WEIGHT; EXPRESSION; INTERLEUKIN-4; KNOCKDOWN; RECEPTORS; VECTORS; CELLS; VITRO; PURIFICATION | AP1-ELPs; Cell penetrating peptide; ELP; Gene delivery; IL-4 receptor; Tumor targeting | Animals; Biopolymers; Cell Line, Tumor; Cell Membrane Permeability; Cell-Penetrating Peptides; Elastin; Female; Gene Transfer Techniques; Genetic Therapy; Humans; Luciferases; Mice, Inbred BALB C; Neoplasm Transplantation; Optical Imaging; Peptides; Receptors, Interleukin-4; RNA, Small Interfering; Transfection; Biocompatibility; Cytology; Elastin; Gene transfer; Glycoproteins; Mammals; Nucleic acids; Peptides; Tumors; amino acid; biopolymer; cell penetrating peptide; drug carrier; elastin; elastin like polypeptide; interleukin 4 receptor; nucleic acid; peptide; peptide AP1; polypeptide; small interfering RNA; unclassified drug; elastin; luciferase; small interfering RNA; AP1-ELPs; Cell-penetrating peptide; Gene Delivery; IL-4 receptor; Tumor targeting; 4T1 cell line; animal cell; animal experiment; animal model; Article; breast cancer; controlled study; cytosol; drug penetration; drug stability; drug targeting; drug uptake; endosome; female; gene delivery system; gene silencing; genetic transfection; human; human cell; in vitro study; in vivo study; lysosome; mouse; nonhuman; tumor cell; tumor escape; validation study; animal; Bagg albino mouse; cancer transplantation; cell membrane permeability; chemistry; fluorescence imaging; gene therapy; gene transfer; genetics; metabolism; tumor cell line; Genes | English | 2020 | 2020-01-17 | 10.1186/s12951-020-0574-z | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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