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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Upstream processes of citrus fruit waste biorefinery for complete valorization | Citrus fruit waste (CW) is a useful biomass and its valorization into fuels and biochemicals has received much attention. For economic feasibility, increased efficiency of the preceding extraction and enzyme saccharification processes is necessary. However, at present, there is a lack of systematic reviews addressing these two integral upstream processes in concert for CW biorefinery. Here, the state-of-the-art advancements in enzyme extraction and saccharification processes-using which relevant essential oils, flavonoids, and sugars can be obtained-are reviewed. Specifically, the extraction options for two commercially available CW-derived products, essential oils and pectin, are discussed. With respect to enzyme saccharification, the use of an undefined commercial mixture routinely results in suboptimal sugar production. In this respect, applicable strategies for enzyme mixture cus-tomization are suggested for maximizing the hydrolytic efficiency of CW. The enzyme degradation system for CW-derived carbohydrates and its extensive application for sugar production are also discussed. | Kim, In Jung; Jeong, Deokyeol; Kim, Soo Rin | Kyungpook Natl Univ, Grad Sch, Dept Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Kyungpook Natl Univ, Res Inst Tailored Food Technol, Daegu 41566, South Korea | Jeong, Deokyeol/GLR-8021-2022; Kim, Soo Rin/X-2192-2019; kim, nayoung/IWV-4038-2023 | 57195531808; 57191332457; 36659584200 | soorinkim@knu.ac.kr; | BIORESOURCE TECHNOLOGY | BIORESOURCE TECHNOL | 0960-8524 | 1873-2976 | 362 | SCIE | AGRICULTURAL ENGINEERING;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENERGY & FUELS | 2022 | 11.4 | 3.6 | 0.57 | 2025-06-25 | 23 | 26 | Citrus fruit waste; Lignocellulose; Pectin; Extraction; Enzyme saccharification | ORANGE PEEL WASTE; ENZYMATIC-HYDROLYSIS; PECTIC OLIGOSACCHARIDES; BY-PRODUCTS; SIMULTANEOUS SACCHARIFICATION; SACCHAROMYCES-CEREVISIAE; LIGNOCELLULOSIC BIOMASS; ESSENTIAL OIL; OPTIMIZATION; EXTRACTION | Citrus fruit waste; Enzyme saccharification; Extraction; Lignocellulose; Pectin | Biomass; Citrus; Fruit; Oils, Volatile; Pectins; Sugars; Systematic Reviews as Topic; Citrus fruits; Efficiency; Enzymes; Essential oils; Extraction; Mixtures; Refining; Saccharification; carbohydrate; essential oil; pectin; Biorefineries; Citrus fruit waste; Economic feasibilities; Enzyme saccharifications; Flavonoid; Pectin; State of the art; Systematic Review; Upstream process; Valorisation; degradation; biomass; Citrus; fruit; Lignocellulose | English | 2022 | 2022-10 | 10.1016/j.biortech.2022.127776 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Whole-brain 3D mapping of oxygen metabolism using constrained quantitative BOLD | Quantitative BOLD (qBOLD) MRI permits noninvasive evaluation of hemodynamic and metabolic states of the brain by quantifying parametric maps of deoxygenated blood volume (DBV) and hemoglobin oxygen saturation level of venous blood (Y-v), and along with a measurement of cerebral blood flow (CBF), the cerebral metabolic rate of oxygen (CMRO2). The method, thus should have potential to provide important information on many neurological disorders as well as normal cerebral physiology. One major challenge in qBOLD is to separate deoxyhemoglobin's contribution to R-2' from other sources modulating the voxel signal, for instance, R-2, R-2' from non-heme iron (R'(2,nh)), and macroscopic magnetic field variations. Further, even with successful separation of the several confounders, it is still challenging to extract DBV and Y-v from the heme-originated R-2' because of limited sensitivity of the qBOLD model. These issues, which have not been fully addressed in currently practiced qBOLD methods, have so far precluded 3D whole-brain implementation of qBOLD. Thus, the purpose of this work was to develop a new 3D MRI oximetry technique that enables robust qBOLD parameter mapping across the entire brain. To achieve this goal, we employed a rapid, R-2'-sensitive, steady-state 3D pulse sequence (termed 'AUSFIDE') for data acquisition, and implemented a prior-constrained qBOLD processing pipeline that exploits a plurality of preliminary parameters obtained via AUSFIDE, along with additionally measured cerebral venous blood volume. Numerical simulations and in vivo studies at 3 T were performed to evaluate the performance of the proposed, constrained qBOLD mapping in comparison to the parent qBOLD method. Measured parameters (Y-v, DBV, R'(2,nh), nonblood magnetic susceptibility) in ten healthy subjects demonstrate the expected contrast across brain territories, while yielding group-averages of 64.0 +/- 2.3 % and 62.2 +/- 3.1 % for Y-v and 2.8 +/- 0.5 % and 1.8 +/- 0.4 % for DBV in cortical gray and white matter, respectively. Given the Y-v measurements, additionally quantified CBF in seven of the ten study subjects enabled whole-brain 3D CMRO2 mapping, yielding group averages of 134.2 +/- 21.1 and 79.4 +/- 12.6 mu mol/100 g/min for cortical gray and white matter, in good agreement with literature values. The results suggest feasibility of the proposed method as a practical and reliable means for measuring neurometabolic parameters over an extended brain coverage. | Lee, Hyunyeol; Wehrli, Felix W. | Univ Penn, Dept Radiol, Lab Struct Physiol & Funct Imaging, Philadelphia, PA 19104 USA; Kyungpook Natl Univ, Sch Elect Engn, Daegu, South Korea | 57193268117; 7007158575 | felix.wehrli@pennmedicine.upenn.edu; | NEUROIMAGE | NEUROIMAGE | 1053-8119 | 1095-9572 | 250 | SCIE | NEUROIMAGING;NEUROSCIENCES;RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2022 | 5.7 | 3.6 | 1.08 | 2025-06-25 | 11 | 11 | Quantitative BOLD; 3D; Constrained inverse problem; Brain metabolism; Hemoglobin oxygen saturation; Cerebral metabolic rate of oxygen | CEREBRAL-BLOOD-FLOW; POSITRON-EMISSION-TOMOGRAPHY; EXTRACTION FRACTION; MAGNETIC-SUSCEPTIBILITY; SPIN-ECHO; VOLUME; MRI; SIGNAL; CALIBRATION; HYPERCAPNIA | 3D; Brain metabolism; Cerebral metabolic rate of oxygen; Constrained inverse problem; Hemoglobin oxygen saturation; Quantitative BOLD | Adult; Brain Mapping; Cerebral Blood Volume; Cerebrovascular Circulation; Female; Hemoglobins; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Male; Oxygen; deoxyhemoglobin; hemoglobin; oxygen; adult; algorithm; Article; BOLD signal; brain blood flow; brain mapping; brain metabolism; cerebral metabolic rate of oxygen; computer simulation; deoxygenation; female; human; human experiment; in vivo study; male; nuclear magnetic resonance imaging; oximetry; oxygen consumption; oxygen saturation; quantitative analysis; steady state; three-dimensional imaging; tissue oxygenation; venous blood; white matter; brain blood volume; brain circulation; brain mapping; image processing; metabolism; physiology; procedures | English | 2022 | 2022-04-15 | 10.1016/j.neuroimage.2022.118952 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Review | Yeast metabolic engineering for carbon dioxide fixation and its application | As numerous industrial bioprocesses rely on yeast fermentation, developing CO2-fixing yeast strains can be an attractive option toward sustainable industrial processes and carbon neutrality. Recent studies have shown that the expression of ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO) in yeasts, such as Saccharomyces cerevisiae and Kluyveromyces marxianus, enables mixotrophic CO2 fixation and production of biofuels. Also, the expression of a synthetic Calvin-Benson-Bassham (CBB) cycle including RuBisCO in Pichia pastoris enables autotrophic growth on CO2. This review highlights recent advances in metabolic engineering strategies to enable CO2 fixation in yeasts. Also, we discuss the potentials of other natural and synthetic metabolic pathways independent of RuBisCO for developing CO2-fixing yeast strains capable of producing value-added biochemicals. | Kim, Soo Rin; Kim, Soo-Jung; Kim, Sun-Ki; Seo, Seung-Oh; Park, Sujeong; Shin, Jamin; Kim, Jeong-Sun; Park, Bo-Ram; Jin, Yong-Su; Chang, Pahn-Shick; Park, Yong-Cheol | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Chonnam Natl Univ, Dept Integrat Food Biosci & Biotechnol, Gwangju 61186, South Korea; Chung Ang Univ, Dept Food Sci & Technol, Anseong 17546, Gyeonggi, South Korea; Catholic Univ Korea, Dept Food Sci & Nutr, Bucheon 14662, South Korea; Chonnam Natl Univ, Dept Chem, Gwangju 61186, South Korea; Rural Dev Adm, Dept Agrofood Resources, Natl Inst Agr Sci, Wonju 55365, South Korea; Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA; Seoul Natl Univ, Dept Agr Biotechnol, Seoul 08826, South Korea; Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 08826, South Korea; Kookmin Univ, Dept Bio & Fermentat Convergence Technol, Seoul 02707, South Korea | Seo, Seung-Oh/GPT-0728-2022; Jin, Yong-Su/L-4530-2013; Kim, Sun/C-2026-2011; Kim, Soo Rin/X-2192-2019 | 36659584200; 57092299400; 54679629800; 55825686000; 57218916250; 57347431000; 7601379316; 56263412100; 57204009076; 35749476600; 56128579600 | ycpark@kookmin.ac.kr; | BIORESOURCE TECHNOLOGY | BIORESOURCE TECHNOL | 0960-8524 | 1873-2976 | 346 | SCIE | AGRICULTURAL ENGINEERING;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;ENERGY & FUELS | 2022 | 11.4 | 3.6 | 0.41 | 2025-06-25 | 15 | 19 | Yeast metabolic engineering; Carbon dioxide fixation; Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO); Calvin-Benson-Bassham (CBB) cycle | SACCHAROMYCES-CEREVISIAE; ACID PRODUCTION; RUBISCO; FERMENTATION; EXPRESSION; REDUCTION; MECHANISM; CHEMICALS; PATHWAY; FUELS | Calvin-Benson-Bassham (CBB) cycle; Carbon dioxide fixation; Ribulose-1,5-bisphosphate carboxylase-oxygenase (RuBisCO); Yeast metabolic engineering | Carbon Cycle; Carbon Dioxide; Metabolic Engineering; Photosynthesis; Ribulose-Bisphosphate Carboxylase; Saccharomyces cerevisiae; Carbon dioxide; Metabolism; Yeast; bioethanol; chaperonin 60; fertilizer; nitrogen; phosphoglycerate kinase; transcriptome; carbon dioxide; ribulosebisphosphate carboxylase; 5-bisphosphate; Calvin-benson-bassham cycle; Carbon dioxide fixation; Industrial bioprocesses; ITS applications; Oxygenases; Ribulose; Ribulose-1,5-bisphosphate carboxylase-oxygenase; Yeast metabolic engineering; Yeast strain; bioengineering; carbon fixation; industrial technology; metabolism; yeast; alcohol production; amino acid sequence; anaerobic fermentation; batch fermentation; biomass; bioremediation; carbon dioxide fixation; carbon nuclear magnetic resonance; carboxylation; fermentation; gene overexpression; glycolysis; hydrolysis; metabolic engineering; metabolic flux analysis; mixotroph; multiplex polymerase chain reaction; nonhuman; oxidative phosphorylation; photosynthesis; protein engineering; Review; Saccharomyces cerevisiae; sequence homology; site directed mutagenesis; carbon cycle; metabolism; Metabolic engineering | English | 2022 | 2022-02 | 10.1016/j.biortech.2021.126349 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Review | Analysis of environmental organic matters by Ultrahigh-Resolution mass spectrometry-A review on the development of analytical methods | Owing to the increasing environmental and climate changes globally, there is an increasing interest in the molecular-level understanding of environmental organic compound mixtures, that is, the pursuit of complete and detailed knowledge of the chemical compositions and related chemical reactions. Environmental organic molecule mixtures, including those in air, soil, rivers, and oceans, have extremely complex and heterogeneous chemical compositions. For their analyses, ultrahigh-resolution and sub-ppb level mass accuracy, achievable using Fourier-transform ion cyclotron resonance mass spectrometry (FT-ICR MS), are important. FT-ICR MS has been successfully used to analyze complex environmental organic molecule mixtures such as natural, soil, particulate, and dissolved organic matter. Despite its success, many limitations still need to be overcome. Sample preparation, ionization, structural identification, chromatographic separation, and data interpretation are some key areas that have been the focus of numerous studies. This review describes key developments in analytical techniques in these areas to aid researchers seeking to start or continue investigations for the molecular-level understanding of environmental organic compound mixtures. | Kim, Sungjune; Kim, Donghwi; Jung, Maeng-Joon; Kim, Sunghwan | Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Korea Inst Ocean Sci & Technol, Oil & POPs Res Grp, Geoje, South Korea; Mass Spectrometry Convergence Res Ctr, Daegu, South Korea; Green Nano Mat Res Ctr, Daegu, South Korea | ; Kim, Sunghwan/HKN-9812-2023 | 57221297786; 58839420600; 56291394700; 57203772967 | sunghwank@knu.ac.kr; | MASS SPECTROMETRY REVIEWS | MASS SPECTROM REV | 0277-7037 | 1098-2787 | 41 | 2 | SCIE | SPECTROSCOPY | 2022 | 6.7 | 3.7 | 1.48 | 2025-06-25 | 43 | 47 | mass spectrometry; molecule; organic matter; ultrahigh-resolution | SOLID-PHASE EXTRACTION; FT-ICR-MS; ION MOBILITY SPECTROMETRY; DOUBLE-BOND EQUIVALENCE; HIGH-FIELD NMR; FLUORESCENCE SPECTROSCOPY; STRUCTURAL-CHARACTERIZATION; MOLECULAR CHARACTERIZATION; LIQUID-CHROMATOGRAPHY; CRUDE-OIL | mass spectrometry; molecule; organic matter; ultrahigh-resolution | Fourier Analysis; Mass Spectrometry; Soil; Biogeochemistry; Climate change; Liquid chromatography; Mass spectrometry; Mixtures; Molecules; Chemical compositions; Chromatographic separations; Dissolved organic matters; Fourier transform ion cyclotron resonance mass spectrometry; Organic compound mixtures; Structural identification; Ultrahigh resolution; Ultrahigh resolution mass spectrometries; Fourier analysis; mass spectrometry; procedures; soil; Organic compounds | English | 2022 | 2022-03 | 10.1002/mas.21684 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Accuracy Validation of Cough Counting AI Algorithm Using a Smartphone App in Patients with Asthma Exacerbation | Lee, S.; Kim, B.; Kim, M.; Kim, S.; Song, C.; Kwon, J.; Shim, J.; Kang, S.; Yang, M.; Kang, S.; Lee, S.; Park, H.; Ahn, K.; Park, H.; Lee, A.; Kim, J. | Gachon Univ, Gil Med Ctr, Internal Med, Incheon, South Korea; Korea Univ, Anam Hosp, Internal Med, Seoul, South Korea; Ewha Womans Univ, Seoul Hosp, Internal Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Internal Med, Seongnam, South Korea; Soundable Hlth Inc, San Francisco, CA USA; Kangwon Univ Hosp, Internal Med, Chunchon, South Korea; SMG SNU Boramae Hosp, Internal Med, Seoul, South Korea; Kyungpook Natl Univ, Internal Med, Daegu, South Korea; Seoul Natl Univ Hosp, Allergy & Clin Immunol Dept, Jongno Gu, South Korea; Seoul Natl Univ Hosp, Internal Med, Seoul, South Korea | sangminlee77@naver.com; | AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | AM J RESP CRIT CARE | 1073-449X | 1535-4970 | 205 | SCIE | CRITICAL CARE MEDICINE;RESPIRATORY SYSTEM | 2022 | 24.7 | 3.8 | 0 | English | 2022 | 2022-05-01 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | An artificial intelligence model to predict hepatocellular carcinoma risk in Korean and Caucasian patients with chronic hepatitis B | Background & Aims: Several models have recently been developed to predict risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Our aims were to develop and validate an artificial intelligence-assisted prediction model of HCC risk. Methods: Using a gradient-boosting machine (GBM) algorithm, a model was developed using 6,051 patients with CHB who received entecavir or tenofovir therapy from 4 hospitals in Korea. Two external validation cohorts were independently established: Korean (5,817 patients from 14 Korean centers) and Caucasian (1,640 from 11 Western centers) PAGE-B cohorts. The primary outcome was HCC development. Results: In the derivation cohort and the 2 validation cohorts, cirrhosis was present in 26.9%-50.2% of patients at baseline. A model using 10 parameters at baseline was derived and showed good predictive performance (c-index 0.79). This model showed significantly better discrimination than previous models (PAGEB, modified PAGE-B, REACH-B, and CU-HCC) in both the Korean (c-index 0.79 vs. 0.64-0.74; all p <0.001) and Caucasian validation cohorts (c-index 0.81 vs. 0.57-0.79; all p <0.05 except modified PAGE-B, p = 0.42). A calibration plot showed a satisfactory calibration function. When the patients were grouped into 4 risk groups, the minimal-risk group (11.2% of the Korean cohort and 8.8% of the Caucasian cohort) had a less than 0.5% risk of HCC during 8 years of follow-up. Conclusions: This GBM-based model provides the best predictive power for HCC risk in Korean and Caucasian patients with CHB treated with entecavir or tenofovir. Lay summary: Risk scores have been developed to predict the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B. We developed and validated a new risk prediction model using machine learning algorithms in 13,508 antiviral-treated patients with chronic hepatitis B. Our new model, based on 10 common baseline characteristics, demonstrated superior performance in risk stratification compared with previous risk scores. This model also identified a group of patients at minimal risk of developing HCC, who could be indicated for less intensive HCC surveillance. (C) 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved. | Kim, Hwi Young; Lampertico, Pietro; Nam, Joon Yeul; Lee, Hyung-Chul; Kim, Seung Up; Sinn, Dong Hyun; Seo, Yeon Seok; Lee, Han Ah; Park, Soo Young; Lim, Young-Suk; Jang, Eun Sun; Yoon, Eileen L.; Kim, Hyoung Su; Kim, Sung Eun; Ahn, Sang Bong; Shim, Jae-Jun; Jeong, Soung Won; Jung, Yong Jin; Sohn, Joo Hyun; Cho, Yong Kyun; Jun, Dae Won; Dalekos, George N.; Idilman, Ramazan; Sypsa, Vana; Berg, Thomas; Buti, Maria; Calleja, Jose Luis; Goulis, John; Manolakopoulos, Spilios; Janssen, Harry L. A.; Jang, Myoung-jin; Lee, Yun Bin; Kim, Yoon Jun; Yoon, Jung-Hwan; Papatheodoridis, George V.; Lee, Jeong-Hoon | Ewha Womans Univ, Coll Med, Dept Internal Med, Seoul, South Korea; Fdn IRCCS Ca Granda Osped Maggiore Policlin, Div Gastroenterol & Hepatol, Milan, Italy; Univ Milan, CRC AM & A Migliavacca Ctr Liver Dis, Dept Pathophysiol & Transplantat, Milan, Italy; Seoul Natl Univ, Liver Res Inst, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Anesthesiol, Coll Med, Seoul, South Korea; Severance Hosp, Dept Internal Med, Yonsei Liver Ctr, Seoul, South Korea; Yonsei Univ, Coll Med, Seoul, South Korea; Sungkyunkwan Univ, Samsung Med Ctr, Dept Internal Med, Sch Med, Seoul, South Korea; Korea Univ, Korea Univ Coll, Dept Internal Med, Anam Hosp, Seoul, South Korea; Inje Univ, Sanggye Paik Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu, South Korea; Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Coll Med, Dept Internal Med, Bundang Hosp, Seoul, South Korea; Hanyang Univ, Hanyang Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Hallym Univ, Hallym Univ Coll Med, Dept Internal Med, Sacred Heart Hosp, Anyang, South Korea; Eulji Univ, Nowon Eulji Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea; Kyung Hee Univ, Dept Internal Med, Sch Med, Seoul, South Korea; Soonchunhyang Univ, Soonchunhyang Univ Seoul Hosp, Dept Internal Med, Coll Med, Seoul, South Korea; Seoul Natl Univ, Dept Internal Med, Boramae Med Ctr, Seoul Metropolitan Govt, Seoul, South Korea; Hanyang Univ, Hanyang Univ Guri Hosp, Dept Internal Med, Coll Med, Guri Si, South Korea; Sungkyunkwan Univ, Kangbuk Samsung Hosp, Dept Internal Med, Sch Med, Seoul, South Korea; Gen Univ Hosp Larissa, Dept Med, Larisa, Greece; Gen Univ Hosp Larissa, Res Lab Internal Med, Natl Expertise Ctr Greece Autoimmune Liver Dis, Larisa, Greece; Ankara Univ, Dept Gastroenterol, Sch Med, Ankara, Turkey; Natl & Kapodistrian Univ Athens, Dept Hyg Epidmiol & Med Stat, Med Sch, Athens, Greece; Univ Leipzig, Dept Med 2, Div Hepatol, Med Ctr, Leipzig, Germany; Hosp Gen Univ Vall Hebron & Ciberehd, Barcelona, Spain; Hosp U Puerta Hierro, IDIPHIM CIBERehd, Madrid, Spain; Aristotle Univ Thessaloniki, Gen Hosp Thessaloniki Hippokratio, Dept Internal Med 4, Med Sch, Thessaloniki, Greece; Natl & Kapodistrian Univ Athens, Gen Hosp Athens Hippokratio, Med Sch Natl, Dept Internal Med 2, Athens, Greece; Univ Hlth Network, Toronto Western & Gen Hosp, Liver Clin, Toronto, ON, Canada; Seoul Natl Univ Hosp, Med Res Collaborat Ctr, Seoul, South Korea; Natl & Kapodistrian Univ Athens, Gen Hosp Athens Laiko, Med Sch Natl, Dept Gastroenterol, Athens, Greece; Kapodistrian Univ Athens, Laiko Gen Hosp Athens, Med Sch Natl, Dept Gastroenterol, 17 Agiou Thoma St, Athens 11527, Greece | Kim, Sun/L-4239-2013; Manolakopoulos, Spilios/AAD-7058-2019; Sinn, Dong/JAC-4247-2023; Papatheodoridis, George/A-4603-2008; Lee, Jeong-Hoon/Q-1055-2018; Lee, Hyung-Chul/U-1910-2019; Kim, Eun Young/JCE-3602-2023; Kiemeney, Lambertus/D-3357-2009; Lee, Yoojin/AAB-9799-2022; SYPSA, VANA/A-5082-2008; Jun, Dae Won/O-4529-2017; Lim, Young-Suk/AFQ-5165-2022; Kim, Kyung/I-5501-2015; Idilman, Ramazan/AFL-0461-2022; Panero, Jose/A-5351-2010; Buti, MARIA/A-5327-2019; Kim, Yoon/J-2746-2012; Yoon, Jung/J-5563-2012 | 56493773500; 7006770607; 57193006895; 55578791400; 54933821200; 23493891100; 35234912400; 57190980926; 57191674344; 57226548822; 35102352800; 35338420100; 7410129808; 57189074365; 57224800099; 35273672400; 55625009600; 56865094300; 57222479854; 35261851400; 8662222500; 7006547284; 7003986090; 6603369653; 15833772800; 7007153523; 7102111355; 6603115432; 6602688592; 56489785600; 55317673900; 55917845400; 25947520600; 16246591600; 7003883848; 55936232200 | gepapath@med.uoa.gr;pindra@empal.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 76 | 2 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 6.35 | 2025-06-25 | 97 | 105 | liver cancer; deep neural networking; antiviral treatment; chronic hepatitis B; HCC; HBV | ENTECAVIR TREATMENT; SCORING SYSTEM; VALIDATION; LAMIVUDINE; CIRRHOSIS; THERAPY; HISTORY; SCORES | antiviral treatment; chronic hepatitis B; deep neural networking; HBV; HCC; liver cancer | Adult; Antiviral Agents; Artificial Intelligence; Asians; Carcinoma, Hepatocellular; Cohort Studies; Computer Simulation; Female; Follow-Up Studies; Guanine; Hepatitis B, Chronic; Humans; Liver Neoplasms; Male; Middle Aged; Republic of Korea; Tenofovir; Whites; alanine aminotransferase; albumin; alpha fetoprotein; bilirubin; entecavir; hepatitis B(e) antigen; tenofovir disoproxil; virus DNA; antivirus agent; entecavir; guanine; tenofovir; adult; alanine aminotransferase blood level; albumin blood level; alpha fetoprotein blood level; antiviral therapy; Article; artificial intelligence; bilirubin blood level; cancer risk; Caucasian; chronic hepatitis B; clinical examination; cohort analysis; comparative study; controlled study; cumulative incidence; discriminant analysis; echography; female; follow up; gradient boosting machine; human; Korean (people); liver carcinogenesis; liver cell carcinoma; liver cirrhosis; major clinical study; male; prediction; prediction of liver cancer using artificial intelligence driven model for network; predictive value; validation therapy; artificial intelligence; Asian; chronic hepatitis B; complication; computer simulation; ethnology; liver cell carcinoma; liver tumor; middle aged; pathophysiology; South Korea | English | 2022 | 2022-02 | 10.1016/j.jhep.2021.09.025 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Diagnostic efficacy of Mac-2 binding protein glycosylation isomer for predicting liver fibrosis in patients with metabolic associated fatty liver disease | Jang, Se Young; Jun, Dae Won; Jo, Hoon Gil; Yoon, Ki Tae; Cho, Young Youn | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Internal Med, Daegu, South Korea; Hanyang Univ, Internal Med, Coll Med, Seoul, South Korea; Wonkwang Univ, Wonkwang Univ Hosp, Internal Med, Sch Med, Iksan, South Korea; Pusan Natl Univ Yangsan Hosp, Internal Med, Pusan, South Korea; Chung Ang Univ Hosp, Internal Med, Seoul, South Korea | Jun, Dae Won/O-4529-2017; Se Young, Jang/MTD-4362-2025 | gongori1004@gmail.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 0 | English | 2022 | 2022-07 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Myosteatosis and excessive visceral adipose tissue as prognostic factors in patients with hepatocellular carcinoma treated with sorafenib | Kang, Min Kyu; Lee, Yu Rim; Jang, Jae Young; Song, Jung Eun; Kweon, Young Oh; Tak, Won Young; Jang, S. E. Young; Lee, Changhyeong; Kim, Byung Seok; Hwang, Jae-Seok; Chung, Woo Jin; Jang, Byoung Kuk; Suh, Jeong Ill; Park, Jung Gil; Park, Soo Young | Yeungnam Univ, Coll Med, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Internal Med, Daegu, South Korea; Daegu Catholic Univ, Sch Med, Internal Med, Daegu, South Korea; Keimyung Univ, Sch Med, Internal Med, Daegu, South Korea; Dongguk Univ, Coll Med, Seoul, South Korea | Kang, Min/U-8050-2018; Kim, Jin Hyoung/AAE-8050-2019; Kim, Seul Kee/A-6076-2015; Park, Jung/AAK-5167-2020 | kmggood111@naver.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 0 | English | 2022 | 2022-07 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | Meeting Abstract | Noninvasive prediction of hepatocellular carcinoma development after oral antiviral therapy in patients with chronic hepatitis C: a multicenter study | Lee, Yu Rim; Park, Jung Gil; Kang, Min Kyu; Song, Jung Eun; Jang, Byoung Kuk; Kweon, Young Oh; Tak, Won Young; Jang, Se Young; Lee, Changhyeong; Kim, Byung Seok; Hwang, Jae-Seok; Chung, Woo Jin; Park, Soo Young; Heo, Nae-Yun; Heo, Jeong; Woo, Hyun Young; Baek, Yanghyon; Yoon, Jun Sik; Jeong, Joonho; Jang, Jae Young | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Daegu, South Korea; Yeungnam Univ, Coll Med, Gyongsan, South Korea; Daegu Catholic Univ, Sch Med, Daegu, South Korea; Keimyung Univ, Sch Med, Daegu, South Korea; Inje Univ, Haeundae Paik Hosp, Coll Med, Gimhae, South Korea; Pusan Natl Univ, Busan, South Korea; Dong A Univ Hosp, Busan, South Korea; Inje Univ, Busan Paik Hosp, Coll Med, Busan, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Ulsan, South Korea | Jeong, Joonho/NIV-1254-2025; Heo, Jeong/MHQ-1390-2025; Kim, Seul Kee/A-6076-2015; Se Young, Jang/MTD-4362-2025; Park, Jung/AAK-5167-2020; Kim, Jin Hyoung/AAE-8050-2019; Kang, Min/U-8050-2018; Heo, Nae-Yun/LUY-9667-2024 | psyoung0419@gmail.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 0 | English | 2022 | 2022-07 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | Phase IIa, randomised, double-blind study of GSK3389404 in patients with chronic hepatitis B on stable nucleos(t)ide therapy | Background & Aims: Bepirovirsen, an antisense oligonucleotide targeting pregenomic and mRNA transcripts of HBV, has been conjugated to N-acetyl galactosamine (GSK3389404) to enhance hepatocyte delivery. This dose-finding study was the first to assess GSK3389404 for chronic HBV infection. Methods: This phase IIa, randomised, double-blind, placebo-controlled, 2-part study was conducted in 22 centres in Asia (NCT03020745). Pharmacokinetic findings from Part 1 informed Part 2 dosing. In Part 2, patients with chronic hepatitis B on nucleos(t)ide analogue therapy were randomised 11:2 to GSK3389404 (30, 60, 120 mg weekly or 120 mg bi-weekly) or placebo until Day 85. Coprimary endpoints included HBsAg response (>= 1.5 log(10) IU/ml reduction from baseline) rate, safety and pharmacokinetics. Results: Parts 1 and 2 included 12 (9 GSK3389404, 3 placebo) and 66 patients (56 GSK3389404, 10 placebo), respectively. In Part 2, one patient each in the 60 mg weekly, 120 mg weekly and 120 mg bi-weekly arms achieved a HBsAg response. HBsAg reductions were dose-dependent (Day 85: mean 0.34 [60 mg weekly] to 0.75 log(10) IU/ml [120 mg weekly]) and occurred in hepatitis B e antigen-positive and -negative patients. No patient achieved HBsAg seroclearance. 43/56 (77%) GSK3389404- and 9/10 (90%) placebo-treated patients reported adverse events. No deaths were reported. Alanine aminotransferase flares (>2x upper limit of normal) occurred in 2 GSK3389404-treated patients (120 mg weekly, 120 mg bi-weekly); both were associated with decreased HBsAg, but neither was considered a responder. GSK3389404 plasma concentrations peaked 2-4 hours post dose; mean plasma half-life was 3-5 hours. Conclusions: GSK3389404 showed an acceptable safety profile and target engagement, with dose-dependent reductions in HBsAg. However, no efficacious dosing regimen was identified. Lay summary: Hepatitis B virus (HBV) can result in chronic HBV infection, which may ultimately lead to chronic liver disease, primary liver cancer and death; HBV proteins may prevent the immune system from successfully controlling the virus. GSK3389404 is an investigational agent that targets HBV RNA, resulting in reduced viral protein production. This study assessed the safety of GSK3389404 and its ability to reduce the viral proteins in patients with chronic HBV infection. GSK3389404 showed dose-dependent reduction in hepatitis B surface antigen, with an acceptable safety profile. While no clear optimal dose was identified, the findings from this study may help in the development of improved treatment options for patients with chronic HBV infections. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | Yuen, Man-Fung; Heo, Jeong; Kumada, Hiromitsu; Suzuki, Fumitaka; Suzuki, Yoshiyuki; Xie, Qing; Jia, Jidong; Karino, Yoshiyasu; Hou, Jinlin; Chayama, Kazuaki; Imamura, Michio; Lao-Tan, Judy Y.; Lim, Seng Gee; Tanaka, Yasuhito; Xie, Wen; Yoon, Jung-Hwan; Duan, Zhongping; Kurosaki, Masayuki; Park, Sung-Jae; Labio, Madalinee Eternity; Kumar, Rajneesh; Kweon, Young-Oh; Yim, Hyung Joon; Tao, Yu; Cremer, Jennifer; Elston, Robert; Davies, Matt; Baptiste-Brown, Sharon; Han, Kelong; Campbell, Fiona M.; Paff, Melanie; Theodore, Dickens | Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China; Pusan Natl Univ, Biomed Res Inst, Coll Med, Pusan, South Korea; Toranomon Hosp Kajigaya, Dept Hepatol, Kanagawa, Japan; Toranomon Hosp Kajigaya, Dept Hepatol, Tokyo, Japan; Shanghai Jiaotong Univ Sch Med, Ruijin Hosp, Dept Infect Dis, Shanghai, Peoples R China; Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing, Peoples R China; Dept Hepatol, Hokkaido PWFa C Sapporo Kosei Gen Hosp, Hokkaido, Japan; Southern Med Univ, Nanfang Hosp, Dept Infect Dis, Guangzhou, Peoples R China; Hiroshima Univ, Collaborat Res Lab Med Innovat, Hiroshima, Japan; Hiroshima Univ, Res Ctr Hepatol & Gastroenterol, Hiroshima, Japan; RIKEN Ctr Integrat Med Sci, Yokohama, Japan; Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Gastroenterol & Metab, Hiroshima, Japan; Cebu Doctors Univ Hosp, Gastroenterol, Cebu, Philippines; Natl Univ Hlth Syst, Dept Med, Div Gastroenterol & Hepatol, Singapore, Singapore; Nagoya City Univ Grad Sch Med Sci, Dept Virol, Liver Unit, Nagoya, Japan; Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis, Beijing, Peoples R China; Seoul Natl Univ Hosp, Seoul Natl Univ Coll Med, Liver Res Inst, Dept Internal Med, Seoul, South Korea; Capital Med Univ, Beijing Youan Hosp, Artif Liver Ctr, Beijing, Peoples R China; Musashino Red Cross Hosp, Dept Gastroenterol & Hepatol, Tokyo, Japan; Inje Univ, Dept Gastroenterol & Hepatol, Busan Paik Hosp, Pusan, South Korea; Makati Med Ctr, Dept Med, Sect Gastroenterol & Hepatol, Makati, Philippines; Singapore Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore; Kyungpook Natl Univ Hosp, Div Gastroenterol & Hepatol, Daegu, South Korea; Korea Univ Ansan Hosp, Dept Internal Med, Ansan, South Korea; GSK, R&D Projects Clin Platforms & Sci, Collegeville, PA USA; GSK, Hepatol GI Clin Sci, Stevenage, Herts, England; GSK, Hepatol GI Clin Sci, Stevenage, Herts, England; GSK, Global Safety, Brentford, England; GSK, R&D Global Med Affairs, Collegeville, PA USA; GSK, Clin Pharmacol Modeling & Simulat, Collegeville, PA USA; GSK, Med Dev Leaders, Collegeville, PA USA; Kumamoto Univ, Fac Life Sci, Dept Gastroenterol & Hepatol, Kumamoto, Japan | ; Heo, Jeong/MHQ-1390-2025; Han, Kelong/J-5233-2014; Lee, Jeong-Hoon/Q-1055-2018; Tanaka, Yasuhito/GNW-5820-2022; Tao, Yu/F-7296-2017; Kumar, Rajneesh/KYQ-0668-2024; Yuen, Richard Man Fung/C-4466-2009; chayama, Kazuaki/G-2917-2019; LIM, Seng/AAD-9040-2020 | 7102031955; 8422238800; 56702093900; 7402448963; 7407199939; 56481035700; 7202343661; 7003525051; 7401966390; 35355550800; 7401595793; 18437024700; 57269602500; 7405315865; 25523010200; 16246591600; 7101936556; 35308923600; 24176295000; 55769531000; 57089434800; 7004694832; 7005664934; 57217331890; 57207829003; 57213448760; 57193126761; 55934565100; 35749846800; 57202653806; 6603210358; 6603830046 | mfyuen@hku.hk; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 2.22 | 2025-06-25 | 34 | 37 | chronic hepatitis B; antisense oligonucleotide; GSK3389404; HBsAg; HBeAg; virological response; safety; pharmacokinetics | PHOSPHOROTHIOATE OLIGONUCLEOTIDES INHIBIT; ANTISENSE OLIGONUCLEOTIDES; SAFETY; PHARMACOKINETICS; TOLERABILITY | antisense oligonucleotide; chronic hepatitis B; GSK3389404; HBeAg; HBsAg; pharmacokinetics; safety; virological response | Alanine Transaminase; Antiviral Agents; DNA, Viral; Double-Blind Method; Galactosamine; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Humans; Oligonucleotides, Antisense; RNA; RNA, Messenger; Viral Proteins; alanine aminotransferase; antisense oligonucleotide; antivirus agent; bepirovirsen; C reactive protein; gsk 3389404; hepatitis B surface antigen; hepatitis B(e) antigen; nucleoside derivative; placebo; prothrombin; unclassified drug; virus DNA; alanine aminotransferase; antisense oligonucleotide; antivirus agent; galactosamine; hepatitis B surface antigen; hepatitis B(e) antigen; messenger RNA; RNA; viral protein; virus DNA; adult; antiviral therapy; Article; chronic hepatitis B; controlled study; double blind procedure; drug blood level; drug safety; drug withdrawal; female; follow up; headache; Hepatitis B virus; human; human tissue; hypertension; injection site erythema; injection site pain; injection site reaction; international normalized ratio; kidney colic; leukocyte count; liver injury; lymphocyte count; major clinical study; malaise; male; multicenter study; myalgia; neutrophil count; nonhuman; pharmacodynamic parameters; pharmacokinetic parameters; phase 2 clinical trial; plasma half life; pruritus; putaminal hemorrhage; randomized controlled trial; rash; reticulocyte count; rhinopharyngitis; side effect; upper respiratory tract infection; variant angina pectoris; chronic hepatitis B; clinical trial; genetics | English | 2022 | 2022-10 | 10.1016/j.jhep.2022.05.031 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Meeting Abstract | Randomized, double-blind, placebo-controlled trial of Tenofovir Alafenamide in children and adolescents with chronic hepatitis B | Schwarz, Kathleen; Bezerra, Jorge; Choe, Byung-Ho; Lin, Chuan-Hao; Abramov, Frida; Nguyen, Anh-Hoa; Liu, Yang; Leisegang, Rory; Flaherty, John F.; Pacurar, Daniela; Kim, Kyung Mo; Khaertynova, Ilsiyar; Shalimar; Wu, Jia-Feng; Tandon, Manish; Rosenthal, Philip; Viacheslav, Morozov; Sokal, Etienne; Chang, Mei-Hwei | Univ Calif San Diego, Sch Med, Rady Childrens Hosp San Diego, San Diego, CA USA; Univ Cincinnati, Cincinnati Childrens Hosp, Cincinnati, OH USA; Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Pediat, Daegu, South Korea; Childrens Hosp Los Angeles, Div Gastroenterol Hepatol & Nutr, Los Angeles, CA 90027 USA; Gilead Sci Inc, Clin Dev, Foster City, CA USA; Gilead Sci Inc, Biostat, Foster City, CA USA; Gilead Sci Inc, Clin Virol, Foster City, CA USA; Gilead Sci Inc, Clin Pharmacol, Foster City, CA USA; Carol Davila Univ Med & Pharm Bucharest, Dept Pediat, Grigore Alexandrescu Emergency Childrens Hosp Buc, Bucharest, Romania; Univ Ulsan, Coll Med, Asan Med Ctr, Childrens Hosp, Seoul, South Korea; Kazan State Med Acad, Kazan, Russia; All India Inst Med Sci, Dept Gastroenterol, New Delhi, India; Natl Taiwan Univ Hosp, Dept Pediat, Taipei, Taiwan; M V Hosp & Res Ctr, Lucknow, Uttar Pradesh, India; Univ Calif San Francisco, Dept Pediat, Div Gastroenterol Hepatol & Nutr, San Francisco, CA 94143 USA; Hepatol LLC, Samara, Russia; Catholic Univ Louvain, Pediat Hepatol & Gastroenterol & Cell Transplant, Clin Univ St Luc, Brussels, Belgium; Natl Taiwan Univ, Taipei, Taiwan; Natl Taiwan Univ, Children Hosp, Dept Pediat, Taipei, Taiwan | Wu, Jia-Feng/H-8125-2019; Rosenthal, Philip/AGG-3493-2022; Pacurar, Daniela/IYS-1131-2023; Choe, Byung-Ho/KSM-6251-2024; WU, JIA-FENG/H-8125-2019; Lin, Chuan-Hao/AAH-6563-2019 | frida.abramov@gilead.com; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 0 | English | 2022 | 2022-07 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Review | Supplemental or dietary intake of omega-3 fatty acids for the treatment of periodontitis: A meta-analysis | Aim To evaluate the intervention effect of omega-3 fatty acids on changes in periodontal parameters. Materials and Methods This meta-analysis included studies published in English language between 2010 and 2020, which were extracted from the Cochrane Library, EMBASE, and PubMed databases. The effects of omega-3 fatty acid intervention were investigated using the amount of omega-3 intake, periodontal pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP). The random-effects model was generated for data analysis. To obtain robustness of the model, sensitivity analysis was implemented. Subgroup analyses were performed based on the intervention period for each parameter. Results All 13 studies included in the meta-analysis were interventional, randomized controlled trials. Two studies implemented omega-3 fatty acid-rich diets, while 11 studies used supplements. Risk of bias was low, and publication bias was not shown. Meta-analysis showed a statistically significant PPD reduction (standardized mean difference [SMD] = -0.81, absolute mean difference [MD] = -0.44 mm), CAL gain (SMD = -0.77, MD = -0.51 mm), and BOP reduction (SMD = -0.65, MD = -9.45%) for the omega-3 fatty acid intervention overall. Conclusion This study suggests that supplemental or dietary intake of omega-3 fatty acids for the treatment of periodontitis may have a positive impact on the disease. | Heo, Hyojin; Bae, Ji-Hyun; Amano, Atsuo; Park, Teajun; Choi, Youn-Hee | Kyungpook Natl Univ, Sch Dent, Dept Prevent Dent, 2177 Dalgubeol Daero, Daegu 41940, South Korea; Keimyung Univ, Dept Food Sci & Nutr, Daegu, South Korea; Osaka Univ, Dept Prevent Dent, Grad Sch Dent, Osaka, Japan; Kyungpook Natl Univ, Inst Translat Res Dent, Daegu, South Korea | 57223365314; 8213707300; 7101649822; 57221686957; 7404777239 | cyh1001@knu.ac.kr; | JOURNAL OF CLINICAL PERIODONTOLOGY | J CLIN PERIODONTOL | 0303-6979 | 1600-051X | 49 | 4 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2022 | 6.7 | 3.8 | 0.46 | 2025-06-25 | 16 | 16 | dietary intake; inflammation; omega-3 fatty acids; periodontitis | POLYUNSATURATED FATTY-ACIDS; LOW-DOSE ASPIRIN; ADJUNCTIVE TREATMENT; MODULATION THERAPY; DOUBLE-BLIND; INFLAMMATION; DISEASE; RATIO; N-3; PROGRESSION | dietary intake; inflammation; omega-3 fatty acids; periodontitis | Eating; Fatty Acids, Omega-3; Humans; Periodontal Pocket; Periodontitis; Tuberculin; arachidonic acid; omega 3 fatty acid; tuberculin; bleeding on probing; bleeding risk score; clinical attachment level; diet supplementation; dietary intake; human; inflammation; periodontal parameters; periodontal pocket depth; periodontitis; quality control; randomized controlled trial (topic); Review; sensitivity analysis; systematic review; eating; meta analysis; periodontal pocket; periodontitis | English | 2022 | 2022-04 | 10.1111/jcpe.13603 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Meeting Abstract | Twenty-year trends in radiofrequency ablation for treatmentnaive hepatocellular carcinoma within the Milan criteria | Jang, Se Young; Park, Soo Young; Lee, Yu Rim; Kweon, Young Oh; Tak, Won Young; Lee, Won Kee; Kim, Sungmin | Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Med Informat, Daegu, South Korea; Univ Ulsan, Biomed Engn, Ulsan, South Korea | Se Young, Jang/MTD-4362-2025 | wytak@knu.ac.kr; | JOURNAL OF HEPATOLOGY | J HEPATOL | 0168-8278 | 1600-0641 | 77 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2022 | 25.7 | 3.8 | 0 | English | 2022 | 2022-07 | 바로가기 | 바로가기 | |||||||||||||||
| ○ | ○ | Article | A newly proposed supercritical carbon dioxide Brayton cycle configuration to enhance energy sources integration capability | A new cycle layout for the supercritical carbon dioxide with its better integration capabilities with heat sources for increased temperature difference across the receiver has been proposed and analyzed in the current study. Design point analysis of the proposed cycle layout and the available cycle layouts in literature, i.e., regenerative, recompression, intercooling, and partial cooling cycles, have been performed and compared. Moreover, the effect of turbine inlet temperature, compressor's inlet pressure, and compressor inlet temperature on the cycle's efficiency, specific work, and integration capabilities with heat source have been studied for all the cycle layouts, including the proposed cycle layout. Results suggest that the proposed cycle's configuration exhibits better integration capabilities than other cycle layouts studied in this work contributing to cost-effective power generation. The cycle's efficiency for the current cycle is comparable with the intercooling cycle, where the specific work value for the proposed process is found maximum among all the cycles. Further, the UA values for the proposed cycle are found up to 33% smaller than the intercooling cycle. (c) 2021 Elsevier Ltd. All rights reserved. | Saeed, Muhammad; Kim, Man-Hoe | Khalifa Univ Sci & Technol, Mech Engn Dept, POB 127788, Abu Dhabi, U Arab Emirates; Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, IEDT, Daegu 41566, South Korea | ; Saeed, Muhammad/R-4401-2019 | 56513270400; 55686310000 | manhoe.kim@knu.ac.kr; | ENERGY | ENERGY | 0360-5442 | 1873-6785 | 239 | SCIE | ENERGY & FUELS;THERMODYNAMICS | 2022 | 8.9 | 4.0 | 2.22 | 2025-06-25 | 32 | 30 | Cycle layout optimization; Printed circuit heat exchanger; System integration; Power generation; SupercriticalCO(2) Brayton cycle | PERFORMANCE ANALYSIS; POWER-GENERATION; CO2; OPTIMIZATION; HEAT | Cycle layout optimization; Power generation; Printed circuit heat exchanger; Supercritical CO<sub>2</sub> Brayton cycle; System integration | Carbon dioxide; Cost effectiveness; Heat exchangers; Printed circuits; Supercritical fluid extraction; Timing circuits; Cycle layout optimization; Integration capability; Intercooling; Layout optimization; Power- generations; Printed circuit heat exchangers; Supercritical carbondioxides; Supercritical CO 2; Supercritical CO2 brayton cycle; System integration; carbon dioxide; cooling; energy resource; heat source; integrated approach; performance assessment; power generation; temperature; Brayton cycle | English | 2022 | 2022-01-15 | 10.1016/j.energy.2021.121868 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | Article | Advanced Real-Time Pollutant Monitoring Systems for Automatic Environmental Management of Construction Projects Focusing on Field Applicability | To minimize damage to people due to pollutants generated from construction work, it is essential to manage environmental performance by maintaining pollutant emissions below regulation standard levels. Therefore, this study aimed to develop a "MOnitoring for Noise, Vibration, and Dust (MONVID)" and evaluate its applicability to construction sites. To do this, two MONVID prototypes with different characteristics were developed considering influential criteria. A field experiment for quantitative evaluation was conducted together with conventional measuring instruments (CMIs), and a questionnaire survey for qualitative evaluation was conducted to determine an appropriate monitoring system. As a result of quantitative evaluation, compared to the monitoring data of CMIs, the reliability class of the MONVIDs I and II were verified with accuracy level (above an "acceptable"). The economic feasibility of MONVID I ($6,531.5) and MONVID II ($6,663.2) were higher than that of CMIs ($8,122.3). This indicates that if MONVID I is applied to a construction site instead of CMIs, it can reduce the cost by 19.6%. In the qualitative evaluation, MONVID II was superior to CMIs and MONVID I in all influential criteria except for reliability (weight: 0.297, ranking: 1) and economic feasibility (weight: 0.107, ranking: 3). Lastly, based on the results of the overall rating, MONVID II (49.4%) was determined as an optimal real-time monitoring system. In conclusion, as a significant study for effectively applying the first developed MONVID to the actual field, the scientific results of this study have proven its field applicability. This study can significantly contribute to managing pollutants using the MONVID instead of CMIs, predicting the civil complaints in advance, and helping make policy decisions related to construction environmental pollutants. | Hong, Taehoon; Sung, Seulki; Kang, Hyuna; Hong, Juwon; Kim, Hakpyeong; Lee, Dong-Eun | Yonsei Univ, Dept Architecture & Architectural Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu 41566, South Korea | ; Hong, Taehoon/E-9169-2012 | hong7@yonsei.ac.kr;seulki0507@yonsei.ac.kr;hyuna_kang@yonsei.ac.kr;juwonae@yonsei.ac.kr;ibk1930@yonsei.ac.kr;dolee@knu.ac.kr; | JOURNAL OF MANAGEMENT IN ENGINEERING | J MANAGE ENG | 0742-597X | 1943-5479 | 38 | 1 | SCIE | ENGINEERING, CIVIL;ENGINEERING, INDUSTRIAL | 2022 | 7.4 | 4.0 | 11 | Real-time monitoring system; Environmental pollutants; Construction site; Performance evaluation; Field applicability | ANALYTIC HIERARCHY PROCESS; ABSOLUTE PERCENTAGE ERROR; EXPOSURE ASSESSMENT; ASSESSMENT MODEL; NOISE EXPOSURE; HEALTH; PREDICTION; DEVICE | English | 2022 | 2022-01-01 | 10.1061/(asce)me.1943-5479.0000980 | 바로가기 | 바로가기 | 바로가기 |
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