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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Targeting Peroxisome Proliferator-Activated Receptor Delta (PPARδ): A Medicinal Chemistry Perspective ⓘ One of the three subtypes of the peroxisome proliferator-activated receptor (PPAR) functioning as a transcription factor is the PPAR beta or PPAR delta. PPAR delta is crucial to pathophysiological processes, including metabolic disorders, liver diseases, and cardiovascular diseases. In the past, the clinical development of PPAR delta-selective agonist drugs has been stalled due to potential safety-related issues. Despite the elusiveness of such a drug, efforts continue in developing drugs that target PPAR delta due to advances in the knowledge of the PPAR delta receptor's structure and functions. While several preclinical and clinical studies are reported on PPAR delta agonists, there is limited data with no clinical evidence available for PPAR delta-selective antagonists. In this review, we mainly focus on the challenges of PPAR delta selectivity and the medicinal chemistry of most active agonists discovered by different pharmaceutical companies and institutes. With this in mind, we also provide an update on the development status of PPAR delta agonists that are undergoing clinical trials and their therapeutic promise for the treatment of various diseases. ⓘ Kadayat, Tara Man; Shrestha, Aarajana; Jeon, Yong Hyun; An, Hongchan; Kim, Jina; Cho, Sung Jin; Chin, Jungwook ⓘ Daegu Gyeongbuk Med Innovat Fdn, New Drug Dev Ctr, Daegu 41061, South Korea; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Daegu Gyeongbuk Med Innovat Fdn, Lab Anim Ctr, Daegu 41061, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41404, South Korea ⓘ An, Hongchan/J-3148-2014; Chin, Jungwook/E-7611-2013; Jeon, Yong/N-6910-2019 ⓘ 50461633400; 56604752500; 16042453400; 40260891900; 56949261900; 58735369700; 36554007700 ⓘ sjcho@dgmif.re.kr;jwchin@dgmif.re.kr; ⓘ JOURNAL OF MEDICINAL CHEMISTRY ⓘ J MED CHEM ⓘ 0022-2623 1520-4804 63 18 SCIE CHEMISTRY, MEDICINAL ⓘ 2020 7.446 4.0 0.48 2025-06-25 ⓘ 26 23 ⓘ ENDOPLASMIC-RETICULUM STRESS; FATTY-ACID OXIDATION; BETA/DELTA AGONIST; LIGAND ACTIVATION; INSULIN-RESISTANCE; MITOCHONDRIAL-FUNCTION; THERAPEUTIC TARGET; CELL PROLIFERATION; NUCLEAR RECEPTORS; HIGHLY POTENT ⓘ ⓘ Animals; Chemistry, Pharmaceutical; Humans; Molecular Structure; Organic Chemicals; PPAR delta; Structure-Activity Relationship; 4 [4 [3 (4 acetyl 3 hydroxy 2 propylphenoxy)propoxy]phenoxy]acetic acid; gw 2433; l 165461; l 631033; l 783483; l 796449; ncp 1046; nn 0606; peroxisome proliferator activated receptor agonist; peroxisome proliferator activated receptor delta; seladelpar; unclassified drug; [2 methyl 4 [4 methyl 2 (4 trifluoromethylphenyl) 5 thiazolylmethylthio]phenoxy]acetic acid; [4 [2 (3 fluoro 4 trifluoromethylphenyl) 4 methyl 5 thiazolylmethylthio] 2 methylphenoxy]acetic acid; organic compound; peroxisome proliferator activated receptor delta; cardiovascular disease; clinical trial (topic); degenerative disease; drug synthesis; drug targeting; human; liver disease; malignant neoplasm; medicinal chemistry; metabolic disorder; nonhuman; protein function; protein structure; Review; structure activity relation; wound healing; animal; chemical structure; chemistry; medicinal chemistry ⓘ English 2020 2020-09-24 10.1021/acs.jmedchem.9b01882 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Safety and Efficacy of Otaplimastat in Patients with Acute Ischemic Stroke Requiring tPA (SAFE-TPA): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Study ⓘ Objective Otaplimastat is a neuroprotectant that inhibits matrix metalloprotease pathway, and reduces edema and intracerebral hemorrhage induced by recombinant tissue plasminogen activator (rtPA) in animal stroke models. We aimed to assess the safety and efficacy of otaplimastat in patients receiving rtPA. Methods This was a phase 2, 2-part, multicenter trial in stroke patients (19-80 years old) receiving rtPA. Intravenous otaplimastat was administered <30 minutes after rtPA. Stage 1 was a single-arm, open-label safety study in 11 patients. Otaplimastat 80 mg was administered twice daily for 3 days. Stage 2 was a randomized, double-blind, placebo-controlled study involving 69 patients, assigned (1:1:1) to otaplimastat 40 mg, otaplimastat 80 mg, or a placebo. The primary endpoint was the occurrence of parenchymal hematoma (PH) on day 1. Secondary endpoints included serious adverse events (SAEs), mortality, and modified Rankin scale (mRS) distribution at 90 days ( identifier: NCT02787278). Results No safety issues were encountered in stage 1. The incidence of PH during stage 2 was comparable: 0 of 22 with the placebo, 0 of 22 with otaplimastat 40 mg, and 1 of 21 with the 80 mg dose. No differences in SAEs (13%, 17%, 14%) or death (8.3%, 4.2%, 4.8%) were observed among the 3 groups. Three adverse events (chills, muscle rigidity, hepatotoxicity) were judged to be related to otaplimastat. Interpretation Intravenous otaplimastat adjunctive therapy in patients receiving rtPA is feasible and generally safe. The functional efficacy of otaplimastat needs to be investigated with further large trials. ANN NEUROL 2019 ⓘ Kim, Jong S.; Lee, Kyung Bok; Park, Jong-Ho; Sung, Sang Min; Oh, Kyungmi; Kim, Eung-Gyu; Chang, Dae-il; Hwang, Yang Ha; Lee, Eun-Jae; Kim, Won-Ki; Ju, Chung; Kim, Byung Su; Ryu, Jei-Man ⓘ Univ Ulsan, Coll Med, Asan Med Ctr, Dept Neurol, Seoul 05505, South Korea; Soonchunhyang Univ, Dept Neurol, Sch Med, Seoul, South Korea; Hanyang Univ, Coll Med, Myongji Hosp, Dept Neurol, Goyang, South Korea; Pusan Natl Univ Hosp, Dept Neurol, Busan, South Korea; Korea Univ, Guro Hosp, Dept Neurol, Seoul, South Korea; Inje Univ, Busan Paik Hosp, Dept Neurol, Busan, South Korea; Kyung Hee Univ Hosp, Dept Neurol, Seoul, South Korea; Kyungpook Natl Univ, Dept Neurol, Sch Med & Hosp, Daegu, South Korea; Korea Univ, Dept Neurosci, Coll Med, Seoul, South Korea; Res Headquarters, Shin Poong Pharmaceut, Ansan, South Korea ⓘ HWANG, Yang-Ha/F-3068-2013; Chang, Dae-il/AAJ-5290-2020; lee, sang/Q-4650-2019; Kim, Sang-Gyu/T-5925-2017 ⓘ 57222278740; 55737448000; 55716977200; 12447103200; 16048029600; 35169942100; 7403319295; 7402311308; 35409781500; 34770946200; 7005046146; 56643414800; 57212026268 ⓘ jongskim@amc.seoul.kr; ⓘ ANNALS OF NEUROLOGY ⓘ ANN NEUROL ⓘ 0364-5134 1531-8249 87 2 SCIE CLINICAL NEUROLOGY;NEUROSCIENCES ⓘ 2020 10.422 4.1 1.38 2025-06-25 ⓘ 16 27 ⓘ TISSUE-PLASMINOGEN ACTIVATOR; HEMORRHAGIC TRANSFORMATION; MATRIX METALLOPROTEINASES; THROMBOLYTIC THERAPY; ALTEPLASE; THROMBECTOMY; INJURY; BRAIN ⓘ ⓘ Administration, Intravenous; Adult; Aged; Aged, 80 and over; Brain Ischemia; Double-Blind Method; Female; Fibrinolytic Agents; Humans; Male; Middle Aged; Neuroprotective Agents; Stroke; Tissue Plasminogen Activator; Treatment Outcome; Young Adult; acetylsalicylic acid; alteplase; clopidogrel; otaplimastat; placebo; fibrinolytic agent; neuroprotective agent; tissue plasminogen activator; adult; aged; Article; atrial fibrillation; brain infarction; brain ischemia; cerebrovascular accident; chill; computer assisted tomography; constipation; controlled study; coughing; depression; diabetes mellitus; diarrhea; dizziness; double blind procedure; drug efficacy; drug safety; dyspepsia; dysuria; fatigue; female; fever; gingiva bleeding; headache; hematoma; hiccup; human; hypokalemia; infarct volume; insomnia; kidney disease; liver toxicity; major clinical study; male; mortality; multicenter study; muscle rigidity; National Institutes of Health Stroke Scale; nausea; open study; parenchymal hematoma; phase 2 clinical trial; priority journal; randomized controlled trial; Rankin scale; rash; stroke patient; urine volume; vomiting; brain ischemia; cerebrovascular accident; clinical trial; complication; intravenous drug administration; middle aged; phase 1 clinical trial; treatment outcome; very elderly; young adult ⓘ English 2020 2020-02 10.1002/ana.25644 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Aerodynamic performance optimization of an airfoil-based airborne wind turbine using genetic algorithm ⓘ The present manuscript proposes an aerodynamically optimized airfoil-based-shell for performance enhancement of the buoyant airborne turbine system. An integrated code, based on a genetic algorithm, is developed to parametrize the asymmetric airfoil NACA-9415, analyse its aerodynamics and optimize the lift of the airfoil. The 3D steady-state analysis is performed on the optimized shell geometry with NREL-IV rotor using Reynolds Averaged Navier-Stokes (RANS) equation along with k- omega SST turbulence model. The performance of the airborne wind turbine with the optimized shell configuration is assessed in terms of aerodynamic coefficients including shell thrust coefficient, shell back pressure coefficient, turbine power coefficient and power augmentation ratio. The comparison of wind turbine performance with optimized and original NACA-9415 shell configuration demonstrates that shell optimization results in a maximum power coefficient of 1.25 and power augmentation ratio of 2.1 compared to the Betz limit. (C) 2020 Elsevier Ltd. All rights reserved. ⓘ Saleem, Arslan; Kim, Man-Hoe ⓘ Kyungpook Natl Univ, Sch Mech Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, IEDT, Daegu 41566, South Korea ⓘ Saleem, Arslan/ABA-5982-2021 ⓘ 57194776354; 55686310000 ⓘ kimmh@asme.org; ⓘ ENERGY ⓘ ENERGY ⓘ 0360-5442 1873-6785 203 SCIE ENERGY & FUELS;THERMODYNAMICS ⓘ 2020 7.147 4.2 2.35 2025-06-25 ⓘ 37 47 Buoyant airborne turbine; Airfoil parametrization; Optimization; Shell aerodynamics; Renewable energy ⓘ COMPUTATIONAL ANALYSIS; ENERGY-SYSTEMS; FLOW-FIELDS ⓘ Airfoil parametrization; Buoyant airborne turbine; Optimization; Renewable energy; Shell aerodynamics ⓘ Aerodynamic configurations; Airfoils; Genetic algorithms; Reynolds equation; Shells (structures); Turbulence models; Wind turbines; Aero-dynamic performance; Aerodynamic coefficients; Performance enhancements; Reynolds-Averaged Navier-Stokes equations; Shell optimization; Steady-state analysis; Thrust coefficients; Turbine performance; aerodynamics; genetic algorithm; optimization; performance assessment; Reynolds number; turbulence; wind turbine; Navier Stokes equations ⓘ English 2020 2020-07-15 10.1016/j.energy.2020.117841 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Neurotrophic interactions between neurons and astrocytes following AAV1-Rheb(S16H) transduction in the hippocampus in vivo ⓘ Background and Purpose We recently reported that AAV1-Rheb(S16H) transduction could protect hippocampal neurons through the induction of brain-derived neurotrophic factor (BDNF) in the rat hippocampus in vivo. It is still unclear how neuronal BDNF produced by AAV1-Rheb(S16H) transduction induces neuroprotective effects in the hippocampus and whether its up-regulation contributes to the enhance of a neuroprotective system in the adult brain. Experimental Approach To determine the presence of a neuroprotective system in the hippocampus of patients with Alzheimer's disease (AD), we examined the levels of glial fibrillary acidic protein, BDNF and ciliary neurotrophic factor (CNTF) and their receptors, tropomyocin receptor kinase B (TrkB) and CNTF receptor alpha(CNTFR alpha), in the hippocampus of AD patients. We also determined whether AAV1-Rheb(S16H) transduction stimulates astroglial activation and whether reactive astrocytes contribute to neuroprotection in models of hippocampal neurotoxicity in vivo and in vitro. Key Results AD patients may have a potential neuroprotective system, demonstrated by increased levels of full-length TrkB and CNTFR alpha in the hippocampus. Further AAV1-Rheb(S16H) transduction induced sustained increases in the levels of full-length TrkB and CNTFR alpha in reactive astrocytes and hippocampal neurons. Moreover, neuronal BDNF produced by Rheb(S16H) transduction of hippocampal neurons induced reactive astrocytes, resulting in CNTF production through the activation of astrocytic TrkB and the up-regulation of neuronal BDNF and astrocytic CNTF which had synergistic effects on the survival of hippocampal neurons in vivo. Conclusions and Implications The results demonstrated that Rheb(S16H) transduction of hippocampal neurons could strengthen the neuroprotective system and this intensified system may have a therapeutic value against neurodegeneration in the adult brain. ⓘ Jeon, Min-Tae; Moon, Gyeong Joon; Kim, Sehwan; Choi, Minji; Oh, Yong-Seok; Kim, Dong Woon; Kim, Hyung-Jun; Lee, Kea Joo; Choe, Youngshik; Ha, Chang Man; Jang, Il-Sung; Nakamura, Michiko; McLean, Catriona; Chung, Won-Suk; Shin, Won-Ho; Lee, Seok-Geun; Kim, Sang Ryong ⓘ Kyungpook Natl Univ, Sch Life Sci, Daegu 41566, South Korea; Kyungpook Natl Univ, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Inst Life Sci & Biotechnol, Daegu, South Korea; Kyung Hee Univ, Grad Sch, Dept Sci Korean Med, Seoul 02447, South Korea; Daegu Gyeongbuk Inst Sci & Technol, Dept Brain Cognit Sci, Seoul, South Korea; Chungnam Natl Univ, Brain Res Inst, Dept Anat, Sch Med, Daejeon, South Korea; Korea Brain Res Inst, Dept Neural Dev & Dis, Dept Struct & Funct Neural Network, Daegu, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Florey Inst Neurosci & Mental Hlth, Victorian Brain Bank Network, Parkville, Vic, Australia; Alfred Hosp, Dept Anat Pathol, Melbourne, Vic, Australia; Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea; Korea Inst Toxicol, Predict Model Res Ctr, Daejeon, South Korea; Kyung Hee Univ, KHU KIST Dept Converging Sci & Technol, Seoul, South Korea ⓘ ; Lee, Seok-Geun/B-3408-2011; Moon, Gyeong/P-7878-2019; kim, dong woon/W-8254-2018; Kim, Dong/W-8254-2018; Chung, Won Suck/B-9011-2016 ⓘ 56018969800; 8323365700; 57193232250; 55461988800; 55506315700; 57204150578; 57191717907; 8579761400; 22833254300; 7202560711; 7102177910; 36051866000; 7103396821; 33867529900; 7202123702; 57368561500; 56486163800 ⓘ seokgeun@khu.ac.kr;srk75@knu.ac.kr; ⓘ BRITISH JOURNAL OF PHARMACOLOGY ⓘ BRIT J PHARMACOL ⓘ 0007-1188 1476-5381 177 3 SCIE PHARMACOLOGY & PHARMACY ⓘ 2020 8.74 4.2 1.23 2025-06-25 ⓘ 17 18 ⓘ TYROSINE KINASE-B; PARKINSONS-DISEASE; DOPAMINE NEURONS; MESSENGER-RNA; GENE-THERAPY; FULL-LENGTH; MOUSE MODEL; BRAIN; EXPRESSION; RECEPTOR ⓘ ⓘ abrineurin; brain derived neurotrophic factor; ciliary neurotrophic factor; ciliary neurotrophic factor receptor alpha; contractile protein; glial fibrillary acidic protein; Rheb protein; tropomyocin receptor kinase B; unclassified drug; Adeno associated virus 1; adult; aged; Alzheimer disease; animal cell; animal experiment; animal model; Article; astrocyte; autopsy; cell interaction; controlled study; female; gene; genetic transduction; hippocampus; human; human cell; human tissue; in vitro study; in vivo study; major clinical study; male; nerve cell; neuroprotection; neurotoxicity; neurotropism; nonhuman; priority journal; rat; Rheb(S16H) gene; upregulation ⓘ English 2020 2020-02 10.1111/bph.14882 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Parametric study of single-stage gravitational water vortex turbine with cylindrical basin ⓘ Gravitational water vortex turbine (GWVT) is one of the emerging micro-hydro power plants because it requires less expertise, low head and reduced setup space for installation. A detailed performance evaluation of the GWVT based on turbine performance curves is yet to be explored. With the help of mathematical expressions along with the experimentation, the present study presents different performance parameters (PPs) such as; rotational speed, torque, brake power and mechanical efficiency of single-stage GWVT under various flow and design conditions. The effect of vortex height, runner position, percentage submergence of blades, notch angle, blades aspect ratio, blades curvature, blades inclination, hub diameter, straight and conical edged blades on the PPs has been investigated. The analytical and experimental results are in a good agreement both qualitatively and quantitatively. The experimental results show that the vortex height and a good vortex shape with fully developed air core are the major parameters in deciding the performance of GWVT. Better performance of GWVT can be achieved at middle of the rotational speed range i.e. between the minimum and maximum load conditions with minimum possible notch angle and hub diameter, using inclined blades of zero curvature fixed near the bottom of the basin. (C) 2020 Elsevier Ltd. All rights reserved. ⓘ Saleem, Abdul Samad; Cheema, Taqi Ahmad; Ullah, Rizwan; Ahmad, Sarvat Mushtaq; Chattha, Javed Ahmad; Akbar, Bilal; Park, Cheol Woo ⓘ GIK Inst Engn Sci & Technol, Fac Mech Engn, Topi 23460, Pakistan; HITEC Univ, Dept Mech Engn, Taxila, Pakistan; Mirpur Univ Sci & Technol, Dept Mech Engn, Mirpur, Ajk, Pakistan; Kyungpook Natl Univ, Sch Mech Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ Ahmad, Sarvat/AAO-4339-2021 ⓘ 57208532073; 36522492600; 57534907400; 24474242300; 12545263000; 57201056075; 7408416474 ⓘ tacheema@giki.edu.pk;chwoopark@knu.ac.kr; ⓘ ENERGY ⓘ ENERGY ⓘ 0360-5442 1873-6785 200 SCIE ENERGY & FUELS;THERMODYNAMICS ⓘ 2020 7.147 4.2 1.81 2025-06-25 ⓘ 25 48 Gravitational water vortex turbine; Performance parameters; Vortex height; Notch angle; Aspect ratio; Blades curvature ⓘ ⓘ Aspect ratio; Blades curvature; Gravitational water vortex turbine; Notch angle; Performance parameters; Vortex height ⓘ Aspect ratio; Hydraulic turbines; Brake power ands; Mathematical expressions; Mechanical efficiency; Microhydro power plants; Parametric study; Performance parameters; Rotational speed; Turbine performance; hydroelectric power plant; numerical model; parameterization; performance assessment; turbine; vortex; Vortex flow ⓘ English 2020 2020-06-01 10.1016/j.energy.2020.117464 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Residues and bio-energy generation: A case study modelling value chain optimisation in Tasmania ⓘ Internationally biomass residues, primarily from forestry and agricultural production cycles, are increasingly being used to produce bio-energy. This case study presents modelling of the potential socioeconomic impacts from a proposed co-generation bio-energy plant (under 50 MW) in the Valley Central Industrial Precinct (VCIP) in Northern Tasmania. The modelling uses data related to residue availability and bio-energy generation output to examine and evaluate potential impacts under a range of scenarios. Potential bio-energy residue feedstock is categorised into viable onsite and offsite sources and quantified in terms of their different bio-energy outputs for different sized bio-energy plants. To complete the evaluation of the potential socio-economic impact of the proposed plant, analysis is conducted using the JEDI (Jobs and Economic Development Impact model). The results of the modelling indicate that the location, quality and quantity of biomass residue feedstock and optimal socio-economic impacts are best aligned with the local supply chain by a bio-energy plant of (10 MW). Importantly, the modelling presented in this paper excludes consideration of forest harvest residues as a potential source of biomass residues due to the lack of certainty on the viability of commercial supply to the VCIP. In this context, it is anticipated that the underlying assumptions and approach used in this case study will be of value to other regions exploring the viability of bioenergy generation from biomass residues. (C) 2020 The Authors. Published by Elsevier Ltd. ⓘ Woo, Heesung; Moroni, Martin; Park, Joowon; Taskhiri, Mohammad Sadegh; Turner, Paul ⓘ Kyungpook Natl Univ, Sch Forest Sci & Landscape Architecture, Daegu 41566, South Korea; Univ Tasmania, Coll Sci & Engn, ARC Ctr Forest Value, eLogist Res Grp,Discipline ICT, Hobart, Tas 7001, Australia; Private Forests Tasmania, 30 Patrick St, Hobart, Tas 7000, Australia; Univ Tasmania, Coll Sci & Engn, ARC Ctr Forest Value, Discipline ICT, Hobart, Tas 7001, Australia ⓘ Woo, Heesung/AAG-4028-2020; Turner, Paul/ABE-2261-2021; Taskhiri, Mohammad Sadegh/ABF-5325-2021; Taskhiri, Mohammad Sadegh/H-5812-2011; Turner, Paul/J-7455-2014 ⓘ 57203973789; 56275138900; 55791550500; 36683248800; 35235278800 ⓘ whs1608@gmail.com; ⓘ ENERGY ⓘ ENERGY ⓘ 0360-5442 1873-6785 196 SCIE ENERGY & FUELS;THERMODYNAMICS ⓘ 2020 7.147 4.2 0.2 2025-06-25 ⓘ 5 3 Biomass supply chain; Biomass plant; Forest residue; Socio-economic; Residue utilisation; Value chains ⓘ FOREST BIOMASS; SUPPLY CHAINS; GASIFICATION; BIOENERGY; PYROLYSIS; PLANTS ⓘ Biomass plant; Biomass supply chain; Forest residue; Residue utilisation; Socio-economic; Value chains ⓘ Australia; Tasmania; Agricultural robots; Biomass; Economic analysis; Feedstocks; Forestry; Supply chains; Biomass plants; Biomass supply chain; Forest residue; Residue utilisation; Socio-economics; Value chains; bioenergy; biomass power; crop residue; numerical model; optimization; plant residue; power generation; power plant; resource use; socioeconomic impact; supply chain management; Economic and social effects ⓘ English 2020 2020-04-01 10.1016/j.energy.2020.117007 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Ferritin Nanocage-Based Methyltransferase SETD6 for COVID-19 Therapy ⓘ The transcription factor nuclear factor-kappa B (NF-kappa B) signaling is a mediator of viral infection-mediated inflammation and SET-domain containing 6 (SETD6) is known as a methyltransferase that suppresses the activity of NF-kappa B signaling. However, the downside of the SETD6 is that it cannot be directly utilized as an inflammatory regulator due to the short half-life and poor intracellular delivery. Here, a ferritin nanocage-based delivery system is presented that can maintain the activity of SETD6 in vivo. According to the analysis of severe COVID-19 patients' peripheral blood mononuclear cells (PBMCs), the SETD6 expression is downregulated while that of NF-kappa B is upregulated. By engineering the structure of ferritin, a protein scaffold is fabricated in which short ferritin is decorated with cell-penetrating peptide and nuclear-localizing TAT-NBD peptide together with SETD6, termed TFS. The TFS enhances the SETD6 level and reduces the NF-kappa B signaling in PBMCs of severe COVID-19 patients and subsequently suppresses the cytokine storm. When the TFS is intravenously administered in the cytokine storm mouse model, the survival rate is rescued and the lung tissue damage and cytokine expression are also inhibited. These results indicate that the ferritin nanocage-based peptide delivery system allows stable in vivo delivery and efficient suppression of NF-kappa B signaling-mediated inflammation. ⓘ Kim, Hong Nam; Park, Hee Ho; Lim, Wonhee; Hong, Kyung Soo; Ahn, June Hong; Na, Dong Hee; Kim, In-San; Jang, Jong Geol; Bae, Jong-Sup; Lee, Wonhwa ⓘ Korea Inst Sci & Technol KIST, Brain Sci Inst, Ctr BioMicrosyst, Seoul 02792, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea; Kangwon Natl Univ, Dept Biotechnol & Bioengn, Chunchon 24341, Gangwon Do, South Korea; Korea Res Inst Biosci & Biotechnol, Rare Dis Res Ctr, Daejeon 34141, South Korea; Univ Sci & Technol, Dept Funct Genom, Daejeon 34141, South Korea; Yeungnam Univ, Coll Med, Dept Internal Med, Div Pulmonol & Allergy, Daegu 42415, South Korea; Yeungnam Univ, Med Ctr, Reg Ctr Resp Dis, Daegu 42415, South Korea; Chung Ang Univ, Coll Pharm, Seoul 06974, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Seoul 02792, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea; Kyungpook Natl Univ, Plus KNU Multiom Based Creat Drug Res Team BK21, Res Inst Pharmaceut Sci, Coll Pharm,CMRI, Daegu 41566, South Korea; Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, Daejeon 34141, South Korea ⓘ Kim, Hong Nam/D-2922-2015; Ahn, June/AAB-3093-2019; Bae, Jong-Sup/AAU-9724-2020; Lee, Wonhwa/GLQ-6506-2022; Kim, Hong/D-2922-2015 ⓘ 35205791200; 25029802100; 57202743777; 56645558700; 56645445800; 7103210503; 34770432800; 56645456400; 16021543200; 50161632800 ⓘ jang83@ynu.ac.kr;baejs@knu.ac.kr;wonhwalee@kribb.re.kr; ⓘ ADVANCED FUNCTIONAL MATERIALS ⓘ ADV FUNCT MATER ⓘ 1616-301X 1616-3028 30 48 SCIE CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2020 18.808 4.3 0.46 2025-06-25 ⓘ 10 8 COVID-19; cytokine storm; ferritin; NF-kappa B signaling; SETD6 ⓘ NF-KAPPA-B; OXIDATIVE STRESS; CYTOKINE STORM; SEPSIS; PHOSPHORYLATION; RELA; METHYLATION; CHROMATIN; SARS ⓘ COVID-19; cytokine storm; ferritin; NF-κB signaling; SETD6 ⓘ Cell engineering; Pathology; Peptides; Signaling; Storms; Transcription; Cell-penetrating peptide; Cytokine expression; Intracellular delivery; Methyltransferases; Nuclear factor kappaB; Peptide delivery; Peripheral blood mononuclear cells; Protein scaffolds; Scaffolds (biology) ⓘ English 2020 2020-11 10.1002/adfm.202006110 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Flexible and Semi-Transparent Ultra-Thin CIGSe Solar Cells Prepared on Ultra-Thin Glass Substrate: A Key to Flexible Bifacial Photovoltaic Applications ⓘ For applications to semi-transparent and/or bifacial solar cells in building-integrated photovoltaics and building-applied photovoltaics, studies are underway to reduce the processing cost and time by decreasing the thickness of Cu(In-1-(x),Ga-x)Se-2(CIGSe) absorber to the ultra-thin scale (<= 500 nm). To dynamically and affordably meet the growing demand for electric power, daylighting, and architectural aesthetics of buildings in urban area, flexible semi-transparent ultra-thin (F-STUT) CIGSe solar cells are proposed on flexible ultra-thin glass (UTG) and compared with rigid semi-transparent ultra-thin (STUT) CIGSe solar cells fabricated on soda-lime glass (SLG). At all the tested deposition temperatures of CIGSe, the F-STUT CIGSe solar cells exhibit superior performance compared to the rigid STUT CIGSe solar cells. Furthermore, through realistic measurement under approximate to 1.3-sun illumination, maximum bifacial power conversion efficiency of 11.90% and 13.23% are obtained for SLG and UTG, respectively. The major advantages of using UTG instead of SLG are not only the intrinsic characteristics of UTG, such as flexibility and high transmittance, but also collateral benefits such as the larger CIGSe grain size at the deposition temperature, better CIGSe crystalline quality, more precise controllability of the alkali element, and reduced thickness of the interfacial GaO(x)layer, which enhance the photovoltaic parameters. ⓘ Kim, Dongryeol; Shin, Sang Su; Lee, Sang Min; Cho, Jun-Sik; Yun, Jae Ho; Lee, Ho Seong; Park, Joo Hyung ⓘ Korea Inst Energy Res KIER, Photovolta Res Dept, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea ⓘ Park, Joo Hyung/AAL-5247-2020; Yun, JaeHo/NGS-4691-2025 ⓘ 57194069208; 57217686358; 57221452907; 7403535861; 56431966500; 55706810400; 57193059568 ⓘ joopark@kier.re.kr; ⓘ ADVANCED FUNCTIONAL MATERIALS ⓘ ADV FUNCT MATER ⓘ 1616-301X 1616-3028 30 36 SCIE CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2020 18.808 4.3 1.75 2025-06-25 ⓘ 47 47 bifacial photovoltaics; flexible semi-transparent solar cells; indium-doped tin oxide back-contact; NaF post-deposition treatment; solar cells; ultra-thin Cu(In; Ga)Se-2; ultra-thin glass ⓘ EFFICIENCY ENHANCEMENT; OXIDE BACK; CU(IN,GA)SE-2; NA; LAYER; INTERFACE ⓘ bifacial photovoltaics; flexible semi-transparent solar cells; indium-doped tin oxide back-contact; NaF post-deposition treatment; solar cells; ultra-thin Cu(In,Ga)Se <sub>2</sub>; ultra-thin glass ⓘ Deposition; Gallium compounds; Glass; Lime; Solar power generation; Substrates; Bifacial solar cells; Building applied photovoltaics; Crystalline quality; Deposition temperatures; Intrinsic characteristics; Photovoltaic applications; Photovoltaic parameters; Power conversion efficiencies; Solar cells ⓘ English 2020 2020-09 10.1002/adfm.202001775 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Low-Resistant Electrical and Robust Mechanical Contacts of Self-Attachable Flexible Transparent Electrodes with Patternable Circuits ⓘ Flexible, transparent, conductive electrodes are key elements of emerging flexible electronic and energy devices. Such electrodes should form an intimate physical contact with various active components of flexible devices to ensure stable, low-resistant electrical contacts. However, contact formation techniques are based largely on conventional soldering, conductive pastes, mechanical clamping, and thin film deposition. These generally result in damaged, contaminated, bulky, and uncontrollable contact interfaces. A self-attachable, flexible, transparent, and conductive electrode that is based on a distinctive design of regular grid patterns into which bioinspired adhesive architectures and percolating Ag nanowires are integrated is proposed. Based on this integrated design, the proposed electrode forms reliable, low-resistant electrical contacts; strong mechanical adhesive contacts; and ultra-clean, damage-free contact interfaces with active device components by attaching onto the components without using additional conductive pastes, mechanical pressing, or vacuum deposition processes. The contact interfaces of the electrode and device components remain stable even when the electrode is extremely bent. Moreover, specific electronic circuits can be generated on the electrode surface by a selective deposition of Ag nanowires. This enables simple interconnections of diverse electronic components on its surface. ⓘ Hwang, Insol; Seong, Minho; Yi, Hoon; Ko, Hangil; Park, Hyun-Ha; Yeo, Junyeob; Bae, Won-Gyu; Park, Hyung Wook; Jeong, Hoon Eui ⓘ UNIST, Dept Mech Engn, Ulsan 44919, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Soongsil Univ, Dept Elect Engn, Seoul 06978, South Korea ⓘ Park, Hyung Wook/E-9102-2010; Yeo, Junyeob/I-1287-2013 ⓘ 56344839000; 57193896851; 56344540200; 56998107200; 57193898001; 58692645200; 59783828200; 55537550000; 35490647000 ⓘ hoonejeong@unist.ac.kr; ⓘ ADVANCED FUNCTIONAL MATERIALS ⓘ ADV FUNCT MATER ⓘ 1616-301X 1616-3028 30 17 SCIE CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2020 18.808 4.3 1.62 2025-06-25 ⓘ 58 37 adhesive electrodes; Ag nanowires; bioinspired adhesives; contact formation; flexible transparent electrodes ⓘ BIOINSPIRED DRY ADHESIVES; PERFORMANCE; ELASTOMER; NETWORKS; SHAPE ⓘ adhesive electrodes; Ag nanowires; bioinspired adhesives; contact formation; flexible transparent electrodes ⓘ Adhesives; Deposition; Electric contacts; Flexible electronics; Nanowires; Timing circuits; Ag nanowires; Conductive electrodes; Contact formation; Electronic component; Mechanical pressing; Selective deposition; Thin-film depositions; Vacuum deposition process; Transparent electrodes ⓘ English 2020 2020-04 10.1002/adfm.202000458 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Pt Dopant: Controlling the Ir Oxidation States toward Efficient and Durable Oxygen Evolution Reaction in Acidic Media ⓘ Dissolution of Ir oxides in Ir-based catalysts, which is closely linked to the catalyst activity and stability toward the oxygen evolution reaction (OER) in acidic media, is a critical unresolved problem in the commercialization of water electrolysis. Doping foreign elements into the Ir oxides can accomplish an optimal combination of Ir oxidation states that is conducive to the leaching-resistance of active catalytic sites. Here, it is reported that Pt doping into IrOx-based nanoframe is beneficial in both terms of activity and stability. The Pt-doped IrOx-based nanoframe achieves the mass activity of 0.644 A mg(Ir+Pt)(-1)at 1.53V(RHE), which is 15-fold higher than that of the commercial IrO2. During the accelerated durability test, the Ir-IV-to-Ir(III)ratio of 5 is maintained in the presence of Pt dopant to effectively mitigate the degradation of Ir catalyst, leading to the superb catalyst durability in acidic media. ⓘ Choi, Songa; Park, Jongsik; Kabiraz, Mrinal Kanti; Hong, Youngmin; Kwon, Taehyun; Kim, Taekyung; Oh, Aram; Baik, Hionsuck; Lee, Minseop; Paek, Seung-Min; Choi, Sang-Il; Lee, Kwangyeol ⓘ Korea Univ, Dept Chem, Seoul 02841, South Korea; Korea Univ, Res Inst Nat Sci, Seoul 02841, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea; KBSI, Seoul 02841, South Korea ⓘ Kwon, Taehyun/AAH-9830-2021; Kim, Taekyung/ABG-9346-2020; Paek, Seung-Min/E-4667-2011; Lee, Kwangyeol/A-9269-2010; Lee, Minseop/JVZ-7552-2024; Kabiraz, Mrinal/AAE-6381-2020; Choi, Sang-Il/AGR-1133-2022 ⓘ 57208751493; 56338526300; 57201400780; 57194557373; 57190672792; 59518450200; 54401491900; 7101961237; 57201550392; 7102686289; 56167600800; 8510322900 ⓘ sichoi@knu.ac.kr;kylee1@korea.ac.kr; ⓘ ADVANCED FUNCTIONAL MATERIALS ⓘ ADV FUNCT MATER ⓘ 1616-301X 1616-3028 30 38 SCIE CHEMISTRY, MULTIDISCIPLINARY;CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER ⓘ 2020 18.808 4.3 2.92 2025-06-25 ⓘ 83 73 doping; electrocatalysts; iridium oxides; oxidation states; oxygen evolution reaction ⓘ X-RAY-ABSORPTION; ELECTRONIC-STRUCTURE; WATER OXIDATION; IRIDIUM; CATALYSTS; DISSOLUTION; METALS; SPECTROSCOPY; PERFORMANCE; STABILITY ⓘ doping; electrocatalysts; iridium oxides; oxidation states; oxygen evolution reaction ⓘ Catalytic oxidation; Durability; Iridium compounds; Oxygen; Oxygen evolution reaction; Platinum; Accelerated durability tests; Catalytic sites; Leaching resistance; Mass activity; Optimal combination; Oxidation state; Oxygen evolution reaction (oer); Water electrolysis; Catalyst activity ⓘ English 2020 2020-09 10.1002/adfm.202003935 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Acaricidal effects of methyl benzoate against Tetranychus urticae Koch (Acari: Tetranychidae) on common crop plants ⓘ BACKGROUND Methyl benzoate (MB) is a small, hydrophobic organic compound isolated from the freshwater fern Salvinia molesta (Salviniales: Salviniaceae). It is used as a fragrance and flavor enhancer owing to its pleasant smell. It has also demonstrated potential as a green pesticide for various groups of insects. However, its effects on mites are yet to be studied. RESULTS Here, we assessed the acaricidal and repellent effects of MB against the two-spotted spider mite, Tetranychus urticae Koch (Acari: Tetranychidae), under laboratory and greenhouse conditions. MB demonstrated concentration-dependent contact toxicity against eggs and adults of the mite. A leaf-dipping assay using 1% MB prevented the hatching of 92.7% of eggs and killed 100% of adults within 48 h of treatment. Concentration-mortality statistics were subjected to probit analysis, and the median lethal concentration (LC50) values for eggs and adults were 0.25% and 0.5%, respectively. Treatment with 1% MB showed the highest mortality (100%), with a median lethal time (LT50) estimated of 8.1 h. The efficacy of MB against adults of T. urticae on tomato plants under greenhouse conditions was 97.5% within 96 h post-treatment. Further, MB showed significant repellent activity against adult females of T. urticae, although this declined with time. Spraying with 1% MB (three times per plant) was not phytotoxic to bean, cucumber, pepper, or tomato plants. CONCLUSION MB is highly acaricidal and repellent, but not phytotoxic, and is a promising green pesticide. ⓘ Mostafiz, Md Munir; Shim, Jae-Kyoung; Hwang, Hwal-Su; Bunch, Heeyoun; Lee, Kyeong-Yeoll ⓘ Kyungpook Natl Univ, Coll Agr & Life Sci, Div Appl Biosci, Daegu 41566, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu, South Korea; Kyungpook Natl Univ, Sustainable Agr Res Ctr, Gunwi, South Korea ⓘ ; Bunch, Heeyoun/JAX-3215-2023; Mostafiz, Md. Munir/AAD-7664-2019 ⓘ 57204895546; 7201856347; 57204055221; 56336812200; 57217153096 ⓘ leeky@knu.ac.kr; ⓘ PEST MANAGEMENT SCIENCE ⓘ PEST MANAG SCI ⓘ 1526-498X 1526-4998 76 7 SCIE AGRONOMY;ENTOMOLOGY ⓘ 2020 4.845 4.4 2.08 2025-06-25 ⓘ 25 25 acaricidal activity; repellent activity; green pesticide; methyl benzoate; two-spotted spider mite; phytotoxicity ⓘ 2-SPOTTED SPIDER-MITE; BENZYL BENZOATE; ESSENTIAL OILS; REPELLENT; TOXICITY; L.; CONSTITUENTS; COLEOPTERA; FRAGRANCE; EFFICACY ⓘ acaricidal activity; green pesticide; methyl benzoate; phytotoxicity; repellent activity; two-spotted spider mite ⓘ Acaricides; Animals; Benzoates; Female; Insect Repellents; Tetranychidae; Acari; Cucumis sativus; Filicophyta; Hexapoda; Hydropteridales; Lycopersicon esculentum; Salvinia molesta; Salviniaceae; Tetranychidae; Tetranychus urticae; acaricide; benzoic acid; insect repellent; methyl benzoate; acaricide; chemical compound; concentration (composition); crop plant; freshwater environment; mite; mortality; pesticide; repellent; toxicity; animal; female; Tetranychidae ⓘ English 2020 2020-07 10.1002/ps.5770 ⓘ 바로가기 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ CADHERINS GUIDE THE DIRECTIONAL MIGRATION OF THE SYNOVIOCYTES IN RHEUMATOID ARTHRITIS ⓘ ⓘ Kang, J. H.; Ahamed, S.; Sa, K. H.; Han, S. W.; Kang, Y. M. ⓘ Kyungpook Natl Univ, Sch Med, Daegu, South Korea ⓘ Ahmed, Sarfraz/ABE-7736-2021; Han, Seungwoo/R-5326-2019; Li, Shaofu/O-2241-2019 ⓘ ⓘ ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 79 SCIE RHEUMATOLOGY ⓘ 2020 19.103 4.4 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 10.1136/annrheumdis-2020-eular.6426 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ COMPARISON OF BONE SCINTIGRAPHY AND FDG-PET/CT IN THE EVALUATION OF DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS: VALIDATION OF BONE SCINTIGRAPHY ⓘ ⓘ Lee, S. J.; Hong, C. M.; Nam, E. J.; Kang, Y. M. ⓘ Kyungpook Natl Univ, Sch Med, Dept Internal Med, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea ⓘ Li, Shaofu/O-2241-2019 ⓘ ⓘ ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 79 SCIE RHEUMATOLOGY ⓘ 2020 19.103 4.4 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 10.1136/annrheumdis-2020-eular.5727 ⓘ 바로가기 바로가기 바로가기
○ Meeting Abstract ⓘ EXPRESSION PROFILE ANALYSIS OF LONG NONCODING RNAS INDUCED BY IL-1SS IN RHEUMATOID ARTHRITIS FIBROBLAST-LIKE SYNOVIOCYTES ⓘ ⓘ Kim, J. M.; Kang, H. J.; Jung, S. J.; Song, B. W.; Jeong, H. J.; Son, C. N.; Kim, S. H.; Hur, K. ⓘ Keimyung Univ, Dongsan Med Ctr, Coll Med, Div Rheumatol,Dept Internal Med, Daegu, South Korea; Keimyung Univ, Grad Sch, Dept Internal Med, Daegu, South Korea; Keimyung Univ, Sch Med, Dept Anat, Daegu, South Korea; Kyungpook Natl Univ, Dept Biochem & Cell Biol, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea ⓘ Kim, Sun/C-2026-2011; Song, Bowen/JCF-0225-2023 ⓘ ⓘ ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 79 SCIE RHEUMATOLOGY ⓘ 2020 19.103 4.4 ⓘ 0 ⓘ ⓘ ⓘ ⓘ English 2020 2020-06 10.1136/annrheumdis-2020-eular.3072 ⓘ 바로가기 바로가기 바로가기
○ ○ Article ⓘ Genome-wide association study in a Korean population identifies six novel susceptibility loci for rheumatoid arthritis ⓘ Objective Genome-wide association studies (GWAS) in rheumatoid arthritis (RA) have discovered over 100 RA loci, explaining patient-relevant RA pathogenesis but showing a large fraction of missing heritability. As a continuous effort, we conducted GWAS in a large Korean RA case-control population. Methods We newly generated genome-wide variant data in two independent Korean cohorts comprising 4068 RA cases and 36 487 controls, followed by a whole-genome imputation and a meta-analysis of the disease association results in the two cohorts. By integrating publicly available omics data with the GWAS results, a series of bioinformatic analyses were conducted to prioritise the RA-risk genes in RA loci and to dissect biological mechanisms underlying disease associations. Results We identified six new RA-risk loci (SLAMF6, CXCL13, SWAP70, NFKBIA, ZFP36L1 and LINC00158) with p(meta)<5x10(-8) and consistent disease effect sizes in the two cohorts. A total of 122 genes were prioritised from the 6 novel and 13 replicated RA loci based on physical distance, regulatory variants and chromatin interaction. Bioinformatics analyses highlighted potentially RA-relevant tissues (including immune tissues, lung and small intestine) with tissue-specific expression of RA-associated genes and suggested the immune-related gene sets (such as CD40 pathway, IL-21-mediated pathway and citrullination) and the risk-allele sharing with other diseases. Conclusion This study identified six new RA-associated loci that contributed to better understanding of the genetic aetiology and biology in RA. ⓘ Kwon, Young-Chang; Lim, Jiwoo; Bang, So-Young; Ha, Eunji; Hwang, Mi Yeong; Yoon, Kyungheon; Choe, Jung-Yoon; Yoo, Dae-Hyun; Lee, Shin-Seok; Lee, Jisoo; Chung, Won Tae; Kim, Tae-Hwan; Sung, Yoon-Kyoung; Shim, Seung-Cheol; Choi, Chan-Bum; Jun, Jae-Bum; Kang, Young Mo; Shin, Jung-Min; Lee, Yeon-Kyung; Cho, Soo-Kyung; Kim, Bong-Jo; Lee, Hye-Soon; Kim, Kwangwoo; Bae, Sang-Cheol ⓘ Hanyang Univ, Inst Rheumatol Res, Seoul, South Korea; Kyung Hee Univ, Dept Biol, Seoul, South Korea; Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul, South Korea; Hanyang Univ Hosp Rheumat Dis, Dept Rheumatol, Seoul, South Korea; Natl Inst Hlth, Div Genome Res, Ctr Genome Sci, Osong Hlth Technol Adm Complex, Cheongju, South Korea; Catholic Univ Daegu, Dept Rheumatol, Sch Med, Daegu, South Korea; Chonnam Natl Univ, Med Sch & Hosp, Dept Internal Med, Div Rheumatol, Gwangju, South Korea; Ewha Womans Univ, Div Rheumatol, Sch Med, Seoul, South Korea; Dong A Univ Hosp, Dept Internal Med, Busan, South Korea; Chungnam Natl Univ Hosp, Div Rheumatol, Dept Internal Med, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Daegu, South Korea ⓘ Bae, Sang-Cheol/P-2051-2015; Kim, Kwangwoo/T-8098-2018; Choi, Chan-Bum/M-4110-2017; Kim, Tae-Hwan/M-3962-2017; Lee, Shin-Seok/AAC-6779-2021; Lee, Seung Hwan/AAE-4710-2022; Li, Shaofu/O-2241-2019; Yoo, Dae/M-3924-2017; Ha, Eunji/MTD-3549-2025 ⓘ 57218574113; 57202803378; 25645654000; 57211941553; 55523326400; 57205678421; 7201513769; 34668711700; 16643309600; 14424388700; 57077585300; 57171134400; 15754508900; 7202796196; 26638662800; 7202753064; 26221798000; 57210826527; 57210831495; 35185890800; 56125152900; 16425988900; 35186283600; 56902138700 ⓘ kkim@khu.ac.kr;scbae@hanyang.ac.kr; ⓘ ANNALS OF THE RHEUMATIC DISEASES ⓘ ANN RHEUM DIS ⓘ 0003-4967 1468-2060 79 11 SCIE RHEUMATOLOGY ⓘ 2020 19.103 4.4 1.55 2025-06-25 ⓘ 31 30 ⓘ GERMINAL CENTER; VARIANTS; JAPANESE; CELLS; CONSORTIUM; ENRICHMENT; EXPRESSION; FEATURES; SMOKING; SLAMF6 ⓘ arthritis; autoimmune diseases; genetic; polymorphism; rheumatoid ⓘ Arthritis, Rheumatoid; Case-Control Studies; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Republic of Korea; chemokine receptor CCR6; CXCL13 chemokine; HLA DRB1 antigen; interleukin 1 receptor associated kinase 1; protein arginine deiminase type 4; STAT4 protein; tumor necrosis factor alpha induced protein 3; allele; ARID5B gene; Article; atrial fibrillation; bioinformatics; case control study; CCR6 gene; chromatin; cohort analysis; controlled study; CXCL13 gene; gene; gene expression; gene locus; genetic correlation; genetic distance; genetic variability; genome-wide association study; Graves disease; GTF2IRD1 gene; HLA DRB1 gene; human; human tissue; IRAK1 gene; Korean (people); LINC00158 gene; major clinical study; NFKBIA gene; NFKBIE gene; PADI4 gene; PLD4 gene; priority journal; RASGRP1 gene; rheumatoid arthritis; SH2B3 gene; SLAMF6 gene; South Korea; STAT4 gene; SWAP70 gene; SYNGR1 gene; systemic lupus erythematosus; TNFAIP3 gene; ZFP36L1 gene; genetic predisposition; genetics; rheumatoid arthritis; single nucleotide polymorphism ⓘ English 2020 2020-11 10.1136/annrheumdis-2020-217663 ⓘ 바로가기 바로가기 바로가기 바로가기
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