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WoS SCOPUS Document Type Document Title Abstract Authors Affiliation ResearcherID (WoS) AuthorsID (SCOPUS) Author Email(s) Journal Name JCR Abbreviation ISSN eISSN Volume Issue WoS Edition WoS Category JCR Year IF JCR (%) FWCI ⓘ FWCI Update Date WoS Citation SCOPUS Citation Keywords (WoS) KeywordsPlus (WoS) Keywords (SCOPUS) KeywordsPlus (SCOPUS) Language Publication Stage Publication Year Publication Date DOI JCR Link DOI Link WOS Link SCOPUS Link
○ ○ Article ⓘ Simulation of advection-diffusion-dispersion equations based on a composite time discretization scheme ⓘ In this work, we develop a high-order composite time discretization scheme based on classical collocation and integral deferred correction methods in a backward semi-Lagrangian framework (BSL) to simulate nonlinear advection-diffusion-dispersion problems. The third-order backward differentiation formula and fourth-order finite difference schemes are used in temporal and spatial discretizations, respectively. Additionally, to evaluate function values at non-grid points in BSL, the constrained interpolation profile method is used. Several numerical experiments demonstrate the efficiency of the proposed techniques in terms of accuracy and computation costs, compare with existing departure traceback schemes. ⓘ Bu, Sunyoung; Bak, Soyoon ⓘ Hongik Univ, Dept Liberal Arts, Sejong, South Korea; Kyungpook Natl Univ, Dept Math, Daegu, South Korea ⓘ Bak, Soyoon/HSE-8486-2023 ⓘ 56450302100; 56450371300 ⓘ jiya525@knu.ac.kr; ⓘ ADVANCES IN DIFFERENCE EQUATIONS ⓘ ADV DIFFER EQU-NY ⓘ 1687-1847 2020 1 SCIE MATHEMATICS, APPLIED;MATHEMATICS ⓘ 2020 2.803 3.8 0.58 2025-06-25 ⓘ 4 4 Time-discretization method; Semi-Lagrangian method; Advection-diffusion equation; Advection-dispersion equation; Burgers' equations; Korteweg-de Vries-Burgers' equation ⓘ ORDER CHARACTERISTICS/FINITE ELEMENTS; DIFFERENTIAL QUADRATURE METHOD; NUMERICAL-SIMULATION; BURGERS-EQUATION; ALGORITHM ⓘ Advection–diffusion equation; Advection–dispersion equation; Burgers’ equations; Korteweg-de Vries–Burgers’ equation; Semi-Lagrangian method; Time-discretization method ⓘ ⓘ English 2020 2020-03-20 10.1186/s13662-020-02580-6 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Molecular imprinting of polymer films on 2D silica inverse opal via thermal graft copolymerization for bisphenol A detection ⓘ Bisphenol A (BPA), which is extensively used in the plastic industry, is a known endocrine disrupting chemical whose release into the environment from industrial products is detrimental to human health. In this study, to characterize BPA-detectable imprinted films on quartz crystals (QCs), sensitive molecularly imprinted quartz crystal microbalance (MIP-QCM) sensors were fabricated. The MIP films were synthesized on 2D porous SiO2 and Au pinholes that were generally observed from replica structures prepared using a polystyrene colloidal monolayer as an insulating mold. For MIP film formation, surface-initiated atom transfer radical polymerization was precisely controlled to adjust the MIP film growth on initiator-modified porous structures. Note that three BPA-imprinted poly(4-VP-co-EGDMA) films, i.e., MIP(8-h), MIP(16-h), and MIP(24-h), under reaction time control were successfully prepared. Furthermore, all imprinted patterned surfaces were characterized via atomic force microscopy (AFM) and scanning electron microscopy (SEM). The MIP(24-h) film demonstrated the highest imprinting factor (i.e., IF approximate to 2.4) and sensitivity (i.e., 1.219 +/- 0.079 Hz nM(-1)), although the maximum binding capacity (Q(max)) and binding capacity (Q(max)) at 1-h rebinding equilibrium was relatively lesser than those of the MIP (8-h) and MIP(16-h) owing to the differentiation of the deposited MIP mass. Using the Freundlich isotherm model, the binding affinity of the BPA imprinted MIP films measured in an aqueous solution of BPA whose concentration ranged between 45 and 225 nM was evaluated. Finally, the selectivity of the MIP-QCM sensors for BPA detection was investigated in aqueous solutions in the presence of other analogous chemicals such as bisphenol F (BPF), bisphenol AP (BPAP), and bisphenol B (BPB). The MIP(8-h) film showed extremely high recovery percentage (approximate to 94.54 %) owing to the relatively thinner film formation, which was significantly com- parable with that of other MIP films, i.e., 68.37 % for MIP(16-h) and 61.99 % for MIP(24-h). However, the MIP (24-h) film appeared to have higher selective features with selectivity coefficients and relative selectivity (k* and k' approximate to 2.5, respectively) despite measurement in a limited period (i.e., 1-h rebinding process). ⓘ Oh, Da Kyeong; Yang, Jin Chul; Hong, Suck Won; Park, Jinyoung ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Pusan Natl Univ, Dept Opt & Mechatron Engn, Dept Cognomechatron Engn, Busandaehak Ro 63 Beon Gil 2, Busan 46241, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ ; PARK, JUN-YOUNG/P-5981-2015 ⓘ 57218437630; 56381794400; 57252820400; 57286293400 ⓘ jinpark@knu.ac.kr; ⓘ SENSORS AND ACTUATORS B-CHEMICAL ⓘ SENSOR ACTUAT B-CHEM ⓘ 0925-4005 323 SCIE CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION ⓘ 2020 7.46 3.9 1.39 2025-06-25 ⓘ 19 22 Surface-initiated atom transfer radical polymerization; Colloidal lithography; Silica pore array; Bisphenol-A; Binding affinity; Sensitivity; Freundlich isotherm ⓘ QUARTZ-CRYSTAL MICROBALANCE; SELF-ASSEMBLED MONOLAYERS; SOLID-PHASE EXTRACTION; AFFINITY DISTRIBUTIONS; SELECTIVE EXTRACTION; SENSOR; WATER; ACID; PARAMETERS; SURFACE ⓘ Binding affinity; Bisphenol-A; Colloidal lithography; Freundlich isotherm; Sensitivity; Silica pore array; Surface-initiated atom transfer radical polymerization ⓘ Atom transfer radical polymerization; Atomic force microscopy; Binding energy; Chemical detection; Crystal atomic structure; Crystals; Endocrine disrupters; Film growth; Film preparation; Free radical reactions; Grafting (chemical); Phenols; Plastic products; Plastics industry; Quartz; Quartz crystal microbalances; Scanning electron microscopy; Sols; Endocrine disrupting chemicals; Freundlich isotherm model; Graft co polymerizations; Molecularly imprinted; Polystyrene colloidal monolayer; Selectivity coefficient; Silica inverse opals; Surface initiated-atom transfer radical polymerization; Polymer films ⓘ English 2020 2020-11-15 10.1016/j.snb.2020.128670 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Molecularly imprinted quartz crystal microbalance sensors with lithographically patterned frisbee-like pillar arrays for sensitive and selective detection of iprodione ⓘ Despite being one of the most widely used fungicides in the agricultural industry, iprodione is a known water pollutant, and its continuous release into water sources is detrimental to human health. In this study, sensitive molecularly imprinted quartz crystal microbalance (MIP-QCM) sensors were prepared by fabricating two types of frisbee-like pillar patterns (MIP-3 mu m and MIP-5 mu m) onto the surface of gold quartz crystals for the real-time detection of iprodione in aqueous solutions. This study describes the synthesis of iprodione-imprinted poly (methacrylic acid-co-2-(trifluoromethyl)acrylic acid-co-ethylene glycol dimethacrylate), referred to as poly (MAA-co-TFMAA-co-EGDMA), in combination with a micro-contact printing technique (mu-CP), via ultraviolet (UV)-assisted photopolymerization. The patterned surfaces with increased surface-to-volume (S/V) ratio were characterized via atomic force microscopy (AFM), scanning force microscopy (SEM), and Fourier-transform infrared spectroscopy (FTIR). The planar imprinted films and the corresponding non-imprinted films were prepared as the control samples for evaluating the sensor's detection capabilities. According to the results, the MIP-QCM sensors had enhanced detection capabilities compared to their planar MIP counterparts owing to the increased binding affinity on the structured surfaces. The imprinting factor (IF) (i.e., Q(e,MIP)/Q(e,NIP)) indicated that the imprinting effects for each MIP film was comparatively assessed, resulting in the following order: 1.69 (MIP-plane)< 2.21 (MIP-5 mu m)< 2.74 (MIP-3 mu m). The LOQ and LOD values were 54.407 and 17.954 nM(-1) (MIP-plane), 24.624 and 8.126 nM(-1) (MIP-5 mu m), and 62.423 and 20.600 nM(-1) (MIP-3 mu m). The binding affinity of the iprodione MIP films was evaluated using the Freundlich isotherm model, and the template amount detected in an iprodione aqueous solution ranged between 30 and 303 nM. Furthermore, the selectivity of the patterned MIP films for iprodione detection was also investigated in aqueous solutions in the presence of two other fungicides: pyrimethanil and procymidone. ⓘ Yang, Jin Chul; Lee, Jihye; Hong, Suck Won; Park, Jinyoung ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, 80 Daehak Ro, Daegu 41566, South Korea; Pusan Natl Univ, Dept Opt & Mechatron Engn, Dept Cognomechatron Engn, Busandaehak Ro 63 Beon Gil 2, Busan 46241, South Korea; Kyungpook Natl Univ, Dept Polymer Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea ⓘ PARK, JUN-YOUNG/P-5981-2015 ⓘ 56381794400; 55689992200; 57252820400; 57286293400 ⓘ swhong@pusan.ac.kr;jinpark@knu.ac.kr; ⓘ SENSORS AND ACTUATORS B-CHEMICAL ⓘ SENSOR ACTUAT B-CHEM ⓘ 0925-4005 320 SCIE CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION ⓘ 2020 7.46 3.9 1.06 2025-06-25 ⓘ 16 17 Molecularly imprinted polymers; Lithography; PDMS molds; Iprodione; Pillar patterns; Freundlich isotherm ⓘ SOLID-PHASE EXTRACTION; FUNCTIONAL MONOMER; BINDING CHARACTERISTICS; AFFINITY DISTRIBUTIONS; POLYMERS; DESIGN; RECOGNITION; PESTICIDES; ACID; NANOSENSOR ⓘ Freundlich isotherm; Iprodione; Lithography; Molecularly imprinted polymers; PDMS molds; Pillar patterns ⓘ Acrylic monomers; Agricultural robots; Agriculture; Binding energy; Crystals; Ethylene; Ethylene glycol; Film preparation; Fourier transform infrared spectroscopy; Fungicides; Photopolymerization; Polyethylenes; Quartz; Scanning tunneling microscopy; Water pollution; Agricultural industries; Detection capability; Ethylene glycol dimethacrylate; Freundlich isotherm model; Micro contact printing; Molecularly imprinted; Quartz crystal microbalance sensors; Structured surfaces; Quartz crystal microbalances ⓘ English 2020 2020-10-01 10.1016/j.snb.2020.128366 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Optical glucose biosensor based on photonic interpenetrating polymer network with solid-state cholesteric liquid crystal and cationic polyelectrolyte ⓘ A patterned photonic array of dots with a photonic interpenetrating polymer network (IPN) structure consisting of intertwined photonic solid-state cholesteric liquid crystals (CLCsolid) and cationic polyelectrolyte networks was utilized for glucose detection. The photonic CLCsolid network was prepared using a reactive mesogen mixture (RMM 727, Merck) doped with the chiral dopant CB15(1), followed by ultraviolet (UV) curing and chiral dopant extraction. The networked cationic polyelectrolyte was prepared by infiltrating a monomer mixture of DMAEMA(2) and acrylic acid (AA) (85:15 mol%) and a crosslinker of TPGDA(3) into the extracted space of the CLCsolid network, UV curing under a photomask, washing the unreacted monomers outside the dots, and immobilizing the glucose oxidase (GOx) at the AA units via a coupling reaction with EDC4. The prepared patterned photonic dots display a clear pH response in terms of a redshift with decreasing pH because the intertwined poly (DMAEMA) (PDMAEMA) is a typical weak cationic polyelectrolyte which protonates and expands at pH values below its pK(b). Thus, the enzymatic reaction of GOx with glucose causes a decrease in pH, expansion of the PDMAEMA, and a redshift of the reflected photonic color. The optimized photonic optical sensor shows a linear range of 0.7-12 mM with a detection limit of 0.021 mM, superior selectivity, and excellent spike test results with real blood serum. The developed photonic IPN sensor is attractive because it is cost-effective, battery-free, and allows easy naked-eye optical detection without the need for sophisticated analytical instrumentation. ⓘ Hussain, Saddam; Park, Soo-Young ⓘ Kyungpook Natl Univ, Sch Appl Chem Engn, Polymer Nano Mat Lab, Daegu 41566, South Korea ⓘ Hussain, Saddam/HMO-5050-2023; park, soo-young/N-3170-2017 ⓘ 57213261490; 57194041850 ⓘ psy@knu.ac.kr; ⓘ SENSORS AND ACTUATORS B-CHEMICAL ⓘ SENSOR ACTUAT B-CHEM ⓘ 0925-4005 316 SCIE CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION ⓘ 2020 7.46 3.9 2.7 2025-06-25 ⓘ 40 45 Cholesteric liquid crystal; Hydrogel polyelectrolyte; Photonic structure; Intertwined polymer network; Biosensor; Glucose ⓘ HYDROGEL; ION ⓘ Biosensor; Cholesteric liquid crystal; Glucose; Hydrogel polyelectrolyte; Intertwined polymer network; Photonic structure ⓘ Acrylic monomers; Ascorbic acid; Cholesteric liquid crystals; Cost effectiveness; Crystal structure; Curing; Glucose; Glucose oxidase; Glucose sensors; Mixtures; Optical Kerr effect; Polyelectrolytes; Red Shift; Analytical Instrumentation; Cationic polyelectrolyte; Enzymatic reaction; Glucose detection; Glucose oxidases (GOx); Interpenetrating polymer network (IPN); Ultraviolet curing; Unreacted monomers; Interpenetrating polymer networks ⓘ English 2020 2020-08-01 10.1016/j.snb.2020.128099 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Selective C2H2 detection with high sensitivity using SnO2 nanorod based gas sensors integrated with a gas chromatography ⓘ We report on the sensitive and selective sensing properties of SnO2 nanorods (NRs) based gas sensors coupled with a miniature gas chromatography (mini-GC) system for the detection of acetylene. The SnO2 NRs were fabricated by a glancing angle deposition (GLAD) method and their average height and diameter were similar to 200 nm and similar to 30 nm, respectively. In order to overcome a selectivity issue of metal oxide semiconductor gas sensors, we integrated our SnO2 NRs based sensors with a packed column. The device accurately and selectively detected acetylene within 2 min (similar to 120 s). We found that loading a thin layer (5 nm) of metal catalysts such as Au, Pt or Pd increases the sensing abilities of the SnO2 NRs sensors. Among the tested sensors, the Pd-coated SnO2 NRs sensor (Pd-SnO2 NRs) exhibited the best sensing performance for the detection of 10 ppm of acetylene and the lower detection limit of 0.01 ppm. The superior sensing properties of Pd-SnO2 NRs are due to the large amount of oxygen deficiencies on the surface of Pd-SnO2 NRs, which acts as reactive sites. More importantly, the mini-GC device can be used to selectively detect 10 ppm of acetylene from other gases such as H-2. Our findings demonstrate that Pd-SnO2 NRs integrated with a mini-GC device can be utilized to monitor the dissolved acetylene gas in transformer oil in real time. ⓘ Lee, Jun Ho; Park, Min Sun; Jung, Hwaebong; Choe, Yong-Sahm; Kim, Wonkyung; Song, Young Geun; Kang, Chong-Yun; Lee, Hyun-Sook; Lee, Wooyoung ⓘ Yonsei Univ, Dept Mat Sci & Engn, 50 Yonsei Ro, Seoul 03722, South Korea; iSenlab Inc, Dunchon Daero 545, Seongnam Si 13215, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Sch Nano & Mat Sci & Engn, 2559 Gyeongsang Daero, Sangju Si 37224, Gyeongsangbuk D, South Korea; Korea Univ, Display & Nanosyst Lab, Sch Elect Engn, Seoul 02841, South Korea; KIST, Ctr Elect Mat, Seoul 02791, South Korea; Korea Univ, KU KIST Grad Sch Converging Sci & Technol, Seoul 02841, South Korea ⓘ Choe, Yong-Sahm/MBV-9415-2025; Kang, Chong-Yun/K-4889-2012; Lee, Jun-Ho/D-4286-2011; Park, Sang/J-5484-2012 ⓘ 58744499900; 57210556714; 54997711600; 57203284412; 55492072500; 57193267701; 7402312786; 59475291400; 55498383000 ⓘ h-slee@yonsei.ac.kr;wooyoung@yonsei.ac.kr; ⓘ SENSORS AND ACTUATORS B-CHEMICAL ⓘ SENSOR ACTUAT B-CHEM ⓘ 0925-4005 307 SCIE CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION ⓘ 2020 7.46 3.9 3.02 2025-06-25 ⓘ 62 64 Acetylene gas sensor; SnO2 nanorod array; Metal catalyst; Miniaturized gas chromatography; Dissolved gas analysis; Transformer oil ⓘ SENSING PROPERTIES; MICROSTRUCTURES; ACETONE; SYSTEM ⓘ Acetylene gas sensor; Dissolved gas analysis; Metal catalyst; Miniaturized gas chromatography; SnO<sub>2</sub> nanorod array; Transformer oil ⓘ Acetylene; Catalysts; Chemical sensors; Gas chromatography; Gas detectors; Gases; Insulating oil; Lighting; Metals; MOS devices; Nanorods; Oil filled transformers; Oxide semiconductors; Acetylene gas; Dissolved gas analysis; Glancing angle deposition methods; Lower detection limit; Metal catalyst; Metal oxide semiconductor gas sensors; Nano-rod arrays; Sensing performance; Semiconducting tin compounds ⓘ English 2020 2020-03-15 10.1016/j.snb.2019.127598 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Taste sensor based on the floating gate structure of a lateral double-diffused metal-oxide semiconductor ⓘ This study reports the evaluation of taste sensor applications using a lateral double-diffused metal-oxide semiconductor (LDMOS) with floating gate structures. This is the first study to use a LDMOS device, coated with a lipid membrane, to detect multiple tastes. The proposed device is manufactured based on a standard complementary metal-oxide semiconductor (CMOS) logic process and has a floating-gate structure for targeting sensor applications. Lipid membranes of Methyltrioctylammonium chloride (TOMA), Oleylamine (OAm), Decyl alcohol (DA), Oleic acid (OA), and Dioctyl phosphate (DOP), with different reactivities, were used to observe the drain current changes at various concentrations (1 fM-1 mM) of the five taste substances: sourness, bitterness, sweetness, saltiness, and umami. The experimental results show that the sensor can operate over a wide and dynamic range (1 fM-1 mM), exhibits a very low-detection limit of 1 fM, and can classify five substances with different tastes. Thus, this study demonstrates that the proposed device is suitable for application as a taste sensor. ⓘ Jeong, Hyun-Min; Kwon, Hyurk-Choon; Xu, Binrui; Jung, Daewoong; Han, Maeum; Kwon, Dae-Hyuk; Kang, Shin-Won ⓘ Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, 1370 Sankyuk Dong, Daegu 702701, South Korea; Korea Inst Ind Technol KITECH, AI Syst Engn Grp, Daegu 42994, South Korea; Kyungil Univ, Dept Elect Engn, Gyongsan 712701, Gyeongsang, South Korea ⓘ ⓘ 55508507100; 9333743700; 57193731156; 36019307900; 55931924500; 7103159872; 7405682695 ⓘ swkang@knu.ac.kr; ⓘ SENSORS AND ACTUATORS B-CHEMICAL ⓘ SENSOR ACTUAT B-CHEM ⓘ 0925-4005 308 SCIE CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;INSTRUMENTS & INSTRUMENTATION ⓘ 2020 7.46 3.9 0.9 2025-06-25 ⓘ 9 11 Lateral double-diffused metal-oxide semiconductor; Taste sensor; Electronic tongue; Lipid membrane; Floating gate ⓘ PERFORMANCE; TRANSISTOR ⓘ Electronic tongue; Floating gate; Lateral double-diffused metal-oxide semiconductor; Lipid membrane; Taste sensor ⓘ Chlorine compounds; CMOS integrated circuits; Dielectric devices; Drain current; Electronic tongues; Lipids; Metallic compounds; Metals; MOS devices; Transistors; Complementary metal oxide semiconductor logic process; Floating gates; Floating-gate structures; Lateral double-diffused metal oxide semiconductors; Lipid membranes; Methyltrioctylammonium chloride; Sensor applications; Taste sensor; Oxide semiconductors ⓘ English 2020 2020-04-01 10.1016/j.snb.2020.127661 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Letter ⓘ Wnt5a and Wnt11 as acute respiratory distress syndrome biomarkers for severe acute respiratory syndrome coronavirus 2 patients ⓘ ⓘ Choi, Eun Young; Park, Hee Ho; Kim, Hyelim; Kim, Hong Nam; Kim, Inyoung; Jeon, Soyoung; Kim, Wantae; Bae, Jong-Sup; Lee, Wonhwa ⓘ Yeungnam Univ, Div Pulm & Allergy, Dept Internal Med, Coll Med, Daegu, South Korea; Yeungnam Univ, Resp Ctr, Med Ctr, Daegu, South Korea; Kangwon Natl Univ, Dept Biotechnol & Bioengn, Chunchon, South Korea; Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea; Korea Inst Sci & Technol KIST, Brain Sci Inst, Ctr BioMicrosyst, Seoul, South Korea; Korea Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul, South Korea; Chungnam Natl Univ, Coll Nat Sci, Dept Biochem, Daejeon, South Korea; Kyungpook Natl Univ, Plus KNU Multiom Based Creat Drug Res Team BK21, Pharmaceut Sci Res Inst, Coll Pharm,CMRI, Daegu, South Korea; Korea Res Inst Biosci & Biotechnol, Aging Res Ctr, 125 Gwahak Ro, Daejeon 34141, South Korea ⓘ Lee, Wonhwa/GLQ-6506-2022; Kim, Hong/D-2922-2015; Kim, Hong Nam/D-2922-2015; Bae, Jong-Sup/AAU-9724-2020 ⓘ 57190418295; 25029802100; 57210146478; 35205791200; 57220110299; 57220110246; 55492085700; 16021543200; 50161632800 ⓘ bywonhwalee@gmail.com; ⓘ EUROPEAN RESPIRATORY JOURNAL ⓘ EUR RESPIR J ⓘ 0903-1936 1399-3003 56 5 SCIE RESPIRATORY SYSTEM ⓘ 2020 16.671 3.9 1.35 2025-06-25 ⓘ 32 28 ⓘ ⓘ ⓘ Adult; Biomarkers; COVID-19; COVID-19 Serological Testing; Female; Humans; Male; Middle Aged; Reproducibility of Results; SARS-CoV-2; Wnt Proteins; Wnt-5a Protein; Young Adult; gamma interferon; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 4; interleukin 6; messenger RNA; transforming growth factor beta; tumor necrosis factor; Wnt11 protein; Wnt5a protein; biological marker; Wnt protein; Wnt11 protein, human; Wnt5a protein; WNT5A protein, human; adult respiratory distress syndrome; aging; blood sampling; body mass; cell isolation; comorbidity; coronavirus disease 2019; cytokine production; disease course; disease severity; enzyme activation; enzyme activity; enzyme inhibition; enzyme linked immunosorbent assay; enzyme regulation; enzyme repression; gene expression; hospital admission; hospital discharge; hospitalization; human; immunocytochemistry; immunohistochemistry; incubation time; infection risk; Letter; lung fibrosis; lung injury; pathology; peripheral blood mononuclear cell; priority journal; prognosis; protein expression; protein secretion; real time polymerase chain reaction; Severe acute respiratory syndrome coronavirus 2; South Korea; survival factor; university hospital; upregulation; adult; blood; diagnosis; female; male; middle aged; reproducibility; young adult ⓘ English 2020 2020-11-01 10.1183/13993003.01531-2020 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An empirical analysis of environmental pollutants on building construction sites for determining the real-time monitoring indices ⓘ Environmental pollutants emitted by various construction work and heavy equipment from construction sites, not only undermine the human living environment but also cause conflicts with residents near the construction sites. Therefore, this study aimed to determine the real-time monitoring indices of environmental pollutants in building construction using the data-mining technique for managing the environmental pollutant emissions inside the construction site and reducing the ambient pollution levels that can impact on the residents near construction sites. Based on the real-time empirical data measured from sensors at a construction site every five minutes during earthwork, this study determined the key impact factors affecting the noise, vibration, and dust in construction sites, as monitoring indices. Then the feasibility of using the real-time monitoring indices for each environmental pollutant was proven through the application of the current relevant policies. The results of this study showed that by controlling the monitoring indices of environmental pollutants in construction sites, the proportions at which the levels of noise, vibration, and dust exceed the current policies can be reduced by up to 61.7%, 3.4%, and 81.2%, respectively. By using the methodology and results of this study, construction companies can systemically plan their construction work considering the key equipment to be used and can effectively manage the pollutants inside the construction sites. ⓘ Hong, Juwon; Kang, Hyuna; Jung, Seunghoon; Sung, Seulki; Hong, Taehoon; Park, Hyo Seon; Lee, Dong-Eun ⓘ Yonsei Univ, Dept Architecture & Architectural Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu, South Korea ⓘ ; Hong, Taehoon/E-9169-2012 ⓘ 57205334533; 57188750703; 57207940898; 57209714762; 57969349700; 55669886900; 56605563300 ⓘ juwonae@yonsei.ac.kr;hyuna_kang@yonsei.ac.kr;saber21@yonsei.ac.kr;seulki0507@yonsei.ac.kr;hong7@yonsei.ac.kr;hspark@yonsei.ac.kr;dolee@knu.ac.kr; ⓘ BUILDING AND ENVIRONMENT ⓘ BUILD ENVIRON ⓘ 0360-1323 1873-684X 170 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;ENGINEERING, ENVIRONMENTAL ⓘ 2020 6.456 4.0 2.26 2025-06-25 ⓘ 38 46 Environmental pollutants; Key impact factors; Real-time indices; Building construction; Earthwork; Data-mining technique ⓘ PARTICULATE MATTER; ENERGY-CONSUMPTION; ASSESSMENT MODEL; NOISE; EMISSIONS; EXPOSURE; SOUND; PROPAGATION; OPERATORS; EQUIPMENT ⓘ Building construction; Data-mining technique; Earthwork; Environmental pollutants; Key impact factors; Real-time indices ⓘ Air pollution; Construction industry; Data mining; Dust; Excavation; Foundations; Pollution detection; Building construction; Earthwork; Environmental pollutants; Key impact factors; Real time; building construction; data mining; earthworks; emission control; empirical analysis; pollutant; pollution monitoring; real time; Construction equipment ⓘ English 2020 2020-03 10.1016/j.buildenv.2019.106636 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ An integrated psychological score for occupants based on their perception and emotional response according to the windows' outdoor view size ⓘ The outdoor view through windows is an indoor environmental factor that significantly affects mental health. Accordingly, the purpose of this study was to develop an integrated psychological score of occupants based on their perception and emotional response according to the outdoor view size. This study used virtual reality technology to realize detailed outdoor view sizes and to control the external effects. In this way, it realized the experiment environment by setting four different outdoor view sizes (20, 40, 60, and 80%) as independent parameters. Through the psychological questionnaire, the subjects' perception of space and their emotional response according to each outdoor view size, were evaluated at the same time. The results of the repeated-measures analysis of variance showed that among the nine factors, anger did not produce statistically meaningful results; as such, it was excluded from the analysis. In addition, through principal component analysis, three orthogonal components were extracted in linear combination. Finally, an integrated psychological score system was developed by using the three aforementioned components based on the weighted Euclidean distance. The results showed that most of the subjects felt psychological dissatisfaction with the 20% outdoor view size, and the highest psychological satisfaction with the 60% size. To verify the results, the subjects were categorized into two groups based on their integrated psychological scores, and their backward numbers test scores were compared. An integrated psychological score is particularly useful considering that the occupancy time is soaring due to the self-isolation caused by the recent COVID-19 pandemic. ⓘ Yeom, Seungkeun; Kim, Hakpyeong; Hong, Taehoon; Park, Hyo Seon; Lee, Dong-Eun ⓘ Yonsei Univ, Dept Architecture & Architectural Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu, South Korea ⓘ ; Hong, Taehoon/E-9169-2012 ⓘ 57211071902; 57199153903; 57969349700; 55669886900; 56605563300 ⓘ hong7@yonsei.ac.kr; ⓘ BUILDING AND ENVIRONMENT ⓘ BUILD ENVIRON ⓘ 0360-1323 1873-684X 180 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;ENGINEERING, ENVIRONMENTAL ⓘ 2020 6.456 4.0 1.62 2025-06-25 ⓘ 48 48 Window view; Virtual reality; Psychology; Principal component analysis ⓘ MULTIOBJECTIVE OPTIMIZATION MODEL; ENVIRONMENTS; EXPOSURE; WORKERS; ENERGY; GENDER ⓘ Principal component analysis; Psychology; Virtual reality; Window view ⓘ Behavioral research; Emotional response; Environmental factors; Independent parameters; Linear combinations; Orthogonal components; Repeated measures; Virtual reality technology; Weighted euclidean distance; environmental factor; experimental study; integrated approach; mental health; perception; principal component analysis; psychology; virtual reality; Principal component analysis ⓘ English 2020 2020-08 10.1016/j.buildenv.2020.107019 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease ⓘ Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including non-alcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy homeostasis, including hepatic lipid metabolism. More specifically, liver-specific 5HT(2A)( )knockout mice exhibit alleviated hepatic lipid accumulation and hepatic steatosis. Here, structural modifications of pimavanserin (CNS drug), a 5HT(2A) antagonist approved for Parkinson's disease, led us to synthesize new peripherally acting SHTZA antagonists. Among the synthesized compounds, compound 14a showed good in vitro activity, good liver microsomal stability, 5HT subtype selectivity, and no significant inhibition of CYP and hERG. The in vitro and in vivo blood-brain barrier permeability study proved that 14a acts peripherally. Compound 14a decreased the liver weight and hepatic lipid accumulation in high-fat-diet-induced obesity mice. Our study suggests new therapeutic possibilities for peripheral 5HT(2A) antagonists in NAFLD. ⓘ Kim, Minhee; Hwang, Inseon; Pagire, Haushabhau S.; Pagire, Suvarna H.; Choi, Wonsuk; Choi, Won Gun; Yoon, Jihyeon; Lee, Won Mi; Song, Jin Sook; Yoo, Eun Kyung; Lee, Seung Mi; Kim, Mi-jin; Bae, Myung Ae; Kim, Dooseop; Lee, Heejong; Lee, Eun-Young; Jeon, Jae-Han; Lee, In-Kyu; Kim, Hail; Ahn, Jin Hee ⓘ Grad Sch Med Sci & Engn, Korea Adv Inst Sci & Technol, Daejeon 34141, South Korea; Gwangju Inst Sci & Technol, Dept Chem, Gwangju 61005, South Korea; JD Biosci, R&D Ctr, Gwangju 61005, South Korea; Korea Res Inst Chem Technol, Bio & Drug Discovery Div, Daejeon, South Korea; Kyungpook Natl Univ Hosp, Leading Edge Res Ctr Drug Discovery & Dev Diabet, Daegu 41010, South Korea; Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea ⓘ ; Kim, Hail/C-5608-2018; CHOI, WON/J-1665-2012; Lee, In-Kyu/AAR-6374-2021; Ahn, Jin/C-6122-2019 ⓘ 57723465700; 57204687317; 55599893000; 56716279400; 57203922980; 57216542768; 57216544129; 57205628657; 57211755720; 56702129400; 57192183947; 56984392800; 7005711682; 56714067000; 57216548394; 59505515200; 36910340400; 36071537600; 7410126420; 56714432600 ⓘ hailkim@kaist.edu;jhahn@gist.ac.kr; ⓘ JOURNAL OF MEDICINAL CHEMISTRY ⓘ J MED CHEM ⓘ 0022-2623 1520-4804 63 8 SCIE CHEMISTRY, MEDICINAL ⓘ 2020 7.446 4.0 0.55 2025-06-25 ⓘ 11 12 ⓘ SEROTONIN RECEPTORS; TRYPTOPHAN; ENHANCEMENT; METABOLISM; TARGET; NAFLD ⓘ ⓘ Animals; Diet, High-Fat; Drug Design; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microsomes, Liver; Non-alcoholic Fatty Liver Disease; Rats, Sprague-Dawley; Serotonin 5-HT2 Receptor Antagonists; 1 (4 fluorobenzyl) 3 (4 isobutoxybenzyl) 1 (piperidin 4 yl)urea; 2 amino [4 [1 (4 fluorobenzyl) 3 (4 isobutoxybenzyl)ureido]piperidin 1 yl] 5 oxopentanoic acid; amino acid derivative; aminoalcohol; buspirone; digestive tract agent; pimavanserin; potassium channel HERG; serotonin 2A antagonist; serotonin 2A receptor; tyrosine derivative; unclassified drug; serotonin 2 antagonist; animal cell; animal experiment; animal model; animal tissue; area under the curve; Article; biological activity; blood brain barrier; brain-to-plasma ratio; CHO-K1 cell line; controlled study; cytotoxicity; diet-induced obesity; drug clearance; drug design; drug dose comparison; drug efficacy; drug half life; drug mechanism; drug potency; drug screening; drug selectivity; drug synthesis; female; HFL1 cell line; human; human cell; IC50; in vitro study; in vivo study; lipid liver level; lipid storage; liver microsome; liver microsome metabolism; liver weight; male; metabolic stability; mouse; NCTC clone 929 cell line; NIH 3T3 cell line; nonalcoholic fatty liver; nonhuman; structure activity relation; unbound fraction; Vero cell line; volume of distribution at steady-state; adverse event; animal; C57BL mouse; drug effect; HEK293 cell line; Institute for Cancer Research mouse; lipid diet; metabolism; nonalcoholic fatty liver; preclinical study; procedures; Sprague Dawley rat; synthesis ⓘ English 2020 2020-04-23 10.1021/acs.jmedchem.0c00002 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ DNA-Encoded Library Screening as Core Platform Technology in Drug Discovery: Its Synthetic Method Development and Applications in DEL Synthesis ⓘ DNA-encoded library technology (DELT) was introduced to our medicinal chemistry society more than 20 years ago. The application of DELT in the development of clinical candidates has been actively reported in the literature recently. A few representative examples include RIP1K inhibitors for inflammatory diseases and sEH inhibitors for endothelial dysfunction or abnormal tissue repair, among many others. Here, the authors would like to recall the recent developments in on-DNA synthetic methodologies for DEL construction and to analyze recent examples in the literature of DELT-based drug development efforts pursued in both the academic and industrial sectors. With this perspective, we hope to provide a useful summary of recent DELT-based drug discovery research and to discuss the future scope of DELT in medicinal chemistry. ⓘ Song, Minsoo; Hwang, Gil Tae ⓘ Daegu Gyeongbuk Med Innovat Fdn DGMIF, New Drug Dev Ctr NDDC, Daegu 41061, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, Daegu 41566, South Korea ⓘ Hwang, Gil Tae/L-6502-2017 ⓘ 56643651800; 7202676087 ⓘ msong@dgmif.re.kr;giltae@knu.ac.kr; ⓘ JOURNAL OF MEDICINAL CHEMISTRY ⓘ J MED CHEM ⓘ 0022-2623 1520-4804 63 13 SCIE CHEMISTRY, MEDICINAL ⓘ 2020 7.446 4.0 3.35 2025-06-25 ⓘ 135 138 ⓘ SMALL-MOLECULE DISCOVERY; CHEMICAL LIBRARIES; SELECTION METHODS; HIGHLY POTENT; BINDING MODE; INHIBITORS; DESIGN; AFFINITY; DISPLAY; IDENTIFICATION ⓘ ⓘ Animals; Chemistry Techniques, Synthetic; Drug Discovery; Drug Evaluation, Preclinical; Gene Library; Humans; aggrecanase 1; antiinfective agent; binding protein; discoidin domain receptor 1; DNA; drug carrier; epoxide hydrolase; gsk 2256294; gsk 2982772; hydrolase inhibitor; metalloproteinase inhibitor; micelle (pharmaceutics); neurokinin 3 receptor antagonist; phosphotransferase inhibitor; protein tyrosine kinase inhibitor; radical; receptor interacting protein 1; transition element; unclassified drug; chemical reaction; DNA synthesis; drug development; gene technology; human; interactions with DNA; medicinal chemistry; molecular library; nonhuman; process optimization; Review; animal; drug development; gene library; preclinical study; procedures; synthesis ⓘ English 2020 2020-07-09 10.1021/acs.jmedchem.9b01782 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Evaluation of Manassantin A Tetrahydrofuran Core Region Analogues and Cooperative Therapeutic Effects with EGFR Inhibition ⓘ Tumors adapt to hypoxia by regulating angiogenesis, metastatic potential, and metabolism. These adaptations mediated by hypoxia-inducible factor 1 (HIF-1) make tumors more aggressive and resistant to chemotherapy and radiation. Therefore, HIF-1 is a validated therapeutic target for cancer. In order to develop new HIF-1 inhibitors for cancer chemotherapy by harnessing the potential of the natural product manassantin A, we synthesized and evaluated manassantin A analogues with modifications in the tetrahydrofuran core region of manassantin A. Our structure-activity relationship study indicated that the alpha,alpha'-trans-configuration of the central ring of manassantin A is critical to HIF-1 inhibition. We also demonstrated that a combination of manassantin A with an epidermal growth factor receptor inhibitor shows cooperative antitumor activity (similar to 80% inhibition for combination vs similar to 30% inhibition for monotherapy). Our findings will provide important frameworks for the future therapeutic development of manassantin A-derived chemotherapeutic agents. ⓘ Kwak, Seung-Hwa; Stephenson, Tesia N.; Lee, Hye-Eun; Ge, Yun; Lee, Hyunji; Min, Sophia M.; Kim, Jea Hyun; Kwon, Do-Yeon; Lee, You Mie; Hong, Jiyong ⓘ Kyungpook Natl Univ, Coll Pharm, BK21 Plus KNU Multiom Creat Drug Res Team, Pharmaceut Sci Res Inst, Daegu 41566, South Korea; Duke Univ, Dept Chem, Durham, NC 27708 USA; Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA ⓘ ; Lee, HyeEun/LZG-8579-2025; Lee, Kyung-Soo/C-9016-2011 ⓘ 56482788300; 56898596200; 56734702100; 57217852719; 56094721600; 57217847818; 57217854202; 55838407300; 8230508600; 7404117896 ⓘ lym@knu.ac.kr;jiyong.hong@duke.edu; ⓘ JOURNAL OF MEDICINAL CHEMISTRY ⓘ J MED CHEM ⓘ 0022-2623 1520-4804 63 13 SCIE CHEMISTRY, MEDICINAL ⓘ 2020 7.446 4.0 0.48 2025-06-25 ⓘ 7 7 ⓘ HYPOXIA-INDUCIBLE FACTORS; STEREOSELECTIVE-SYNTHESIS; CYCLIC ETHERS; TUMOR HYPOXIA; CANCER; ANGIOGENESIS; METATHESIS; AGENTS; HIF-1; HEAD ⓘ ⓘ ErbB Receptors; Furans; HEK293 Cells; Humans; Lignans; Protein Kinase Inhibitors; 1 allyl 2,5 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]pyrrolidine; 1 benzyl 2,5 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]pyrrolidine; 1,2 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]cyclopent 1 ene; 1,4 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]butane 1,4 diol; 1,4 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]butane 1,4 dione; 1,5 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]pentane 1,5 diol; 1,5 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]pentane 1,5 dione; 2,2' [[(1 allylpyrrolidine 2,5 diyl)bis(2 methox 4,1 phenylene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[(3 methyltetrahydrofuran 2,5 diyl)bis (2 methoxy 4,1 phenylene)]bis(oxy)]bis [1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[(pyrrolidine 2,5 diyl)bis(2 methoxy 4,1 phenylene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[(tetrahydro 2h pyran 2,6 diyl)bis(2 methoxy 4,1 phenylene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[(tetrahydrofuran 2,5 diyl)bis(2 methox 4,1 phentlene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[3,3'' dimethoxy (1,1':3',1'' terphenyl) 4,4'' diyl]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[cyclopent 1 ene 1,2 diylbis(2 methoxy 4,1 phenylene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,2' [[pyridine 2,6 diylbis(2 methoxy 4,1 phenylene)]bis(oxy)]bis[1 (3,4 dimethoxyphenyl)propan 1 one]; 2,5 bis [4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]tetrahydrofuran; 2,6 bis[4 (benzyloxy) 3 methoxyphenyl]pyridine; 2,6 bis[4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]tetrahydro 2h pyran; 4,4' (1 benzylpyrrolidine 2,5 diyl)bis(2 methoxyphenol); 4,4'' bis(benzyloxy) 3,3'' dimethoxy 1,1':3',1'' terphenyl; 5 [4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl]dihydrofuran 2(3h) one; antineoplastic agent; epidermal growth factor receptor kinase inhibitor; gefitinib; hypoxia inducible factor 1; manassantin a; methyl 4 [4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl) 4 oxobutanoate; methyl 4 [4 [(tert butyldimethylsilyl)oxy] 3 methoxyphenyl] 4 hydroxybutanoate; tetrahydrofuran derivative; unclassified drug; unindexed drug; epidermal growth factor receptor; furan derivative; lignan; manassantin A; protein kinase inhibitor; tetrahydrofuran; animal experiment; antineoplastic activity; Article; controlled study; drug screening; drug synthesis; male; monotherapy; mouse; nonhuman; structure activity relation; chemistry; HEK293 cell line; human ⓘ English 2020 2020-07-09 10.1021/acs.jmedchem.0c00151 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Gadolinium-Based Neuroprognostic Magnetic Resonance Imaging Agents Suppress COX-2 for Prevention of Reperfusion Injury after Stroke ⓘ Advancements in recanalization therapies have rendered reperfusion injury an important challenge for stroke management. It is essential to work toward effective therapeutics that protect the ischemic brain from reperfusion injury. Here, we report a new concept of neuroprognostic agents, which combine molecular diagnostic imaging and targeted neuroprotection for treatment of reperfusion injury after stroke. These neuroprognostic agents are inflammation-targeted gadolinium compounds conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs). Our results demonstrated that gadolinium-based MRI contrast agents conjugated with NSAIDs suppressed the increase in cyclooxygenase-2 (COX-2) levels, ameliorated glial activation, and neuron damage that are phenotypic for stroke by mitigating neuroinflammation, which prevented reperfusion injury. In addition, this study showed that the neuroprognostic agents are promising T(1 )molecular MRI contrast agents for detecting precise reperfusion injury locations at the molecular level. Our results build on this new concept of neuroprognostics as a novel management strategy for ischemia-reperfusion injury, combining neuroprotection and molecular diagnostics. ⓘ Kim, Hee-Kyung; Lee, Jung-Jin; Choi, Garam; Sung, Bokyung; Kim, Yeoun-Hee; Baek, Ah Rum; Kim, Soyeon; Song, Huijin; Kim, Minsup; Cho, Art E.; Lee, Gang Ho; Moon, Sungjun; Kang, Min-Kyoung; Lee, Jae Jun; Chang, Yongmin ⓘ Kyungpook Natl Univ, Dept Med & Biol Engn, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ, Dept Mol Med, Sch Med, Daegu 41944, South Korea; Kyungpook Natl Univ Hosp, Dept Radiol, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Plus KNU Biomed Convergence Program BK21, Daegu 41944, South Korea; Kyungpook Natl Univ, Inst Biomed Engn Res, Daegu 41944, South Korea; Myungmoon Bio Co, Dept R&D Ctr, Hwaseong 18622, Gyeonggi Do, South Korea; Kyungpook Natl Univ, Dept Med & Biol Engn, Daegu 41944, South Korea; Korea Univ, Dept Bioinformat, Sejong 30019, South Korea; Kyungpook Natl Univ, Dept Chem, Daegu 41566, South Korea; Yeungnam Univ, Dept Radiol, Med Ctr, Daegu 42415, South Korea; KBIO Osong Med Innovat Fdn, Lab Anim Ctr, Osong 28160, South Korea ⓘ ; Choi, Garam/NHP-2919-2025 ⓘ 56014729400; 10143410400; 56013903700; 58929528400; 35311040700; 57194601711; 57203773250; 8231186700; 56122945800; 8586262300; 7404851841; 57189891980; 55904412800; 56467498000; 7501840633 ⓘ ychang@knu.ac.kr; ⓘ JOURNAL OF MEDICINAL CHEMISTRY ⓘ J MED CHEM ⓘ 0022-2623 1520-4804 63 13 SCIE CHEMISTRY, MEDICINAL ⓘ 2020 7.446 4.0 0.4 2025-06-25 ⓘ 6 8 ⓘ ACUTE ISCHEMIC-STROKE; CEREBRAL-ISCHEMIA; NEUROPROTECTION; MECHANISMS; MRI; PATHOPHYSIOLOGY; ACTIVATION; DAMAGE; DEATH; RAT ⓘ ⓘ Animals; Anti-Inflammatory Agents, Non-Steroidal; Contrast Media; Cyclooxygenase 2; Gadolinium; Magnetic Resonance Imaging; Male; Molecular Docking Simulation; Neuroprotective Agents; Protein Conformation; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Stroke; cyclooxygenase 2; cyclooxygenase 2 inhibitor; diflunisal; gadobutrol; gadolinium; gd do3a diflusinal; gd do3a sulindac; glial fibrillary acidic protein; inducible nitric oxide synthase; interleukin 1beta; interleukin 6; neuron specific nuclear protein; neuroprotective agent; nonsteroid antiinflammatory agent; nuclear magnetic resonance imaging agent; sulindac; unclassified drug; contrast medium; cyclooxygenase 2; gadolinium; neuroprotective agent; animal experiment; animal model; Article; brain size; brain tissue; carbon nuclear magnetic resonance; cerebral ischemia reperfusion injury; cerebrovascular accident; computer model; contrast to noise ratio; controlled study; corpus striatum; elimination half-life; high performance liquid chromatography; hydrogen bond; immunofluorescence; in vitro study; lipophilicity; male; microanalysis; middle cerebral artery occlusion; molecular docking; nervous system inflammation; neuroprotection; nonhuman; phenotype; prognosis; protein expression; protein expression level; proton nuclear magnetic resonance; rat; real time polymerase chain reaction; animal; cerebrovascular accident; chemistry; complication; metabolism; nuclear magnetic resonance imaging; protein conformation; reperfusion injury; Sprague Dawley rat ⓘ English 2020 2020-07-09 10.1021/acs.jmedchem.0c00285 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Letter ⓘ Letter to the Editor on "Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy" Reply ⓘ ⓘ Jung, Un Ju; Kim, Sang Ryong ⓘ Pukyong Natl Univ, Dept Food Sci & Nutr, Busan, South Korea; Kyungpook Natl Univ, Sch Life Sci, BK21 Plus KNU Creat BioRes Grp, Daegu, South Korea; Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea ⓘ ⓘ 7007119425; 56486163800 ⓘ jungunju@naver.com;srk75@knu.ac.kr; ⓘ ADVANCES IN NUTRITION ⓘ ADV NUTR ⓘ 2161-8313 2156-5376 11 3 SCIE NUTRITION & DIETETICS ⓘ 2020 8.701 4.0 0 2025-06-25 ⓘ 0 0 ⓘ GRANULE CELL DISPERSION; KAINIC ACID; MOUSE MODEL; DENTATE GYRUS; NEUROTOXICITY; HIPPOCAMPUS ⓘ ⓘ Epilepsy; Flavonoids; Humans; flavonoid; epilepsy; human ⓘ English 2020 2020-05 10.1093/advances/nmaa005 ⓘ 바로가기 바로가기 바로가기 바로가기
○ ○ Article ⓘ Quantitative health impact assessment of construction noise exposure on the nearby region for noise barrier optimization ⓘ As construction noise has become one of the most harmful pollutants for nearby residents, it is essential to quantify the health impacts of noise exposure to reduce them and reduce the number of resident disputes. Accordingly, this study aims to propose a method to assess the quantitative health impact of construction noise exposure on nearby residents and optimize noise barriers based on this health impact. To this end, the health impact of construction noise exposure on nearby residents was quantified as a health damage cost by estimating the environmental burden of disease (EBD) and its economic value based on noise simulations. The results show that the estimated health damage cost reflects the health impact of construction noise exposure on nearby residents within a feasible range of compensation costs compared with the existing compensation criteria. In addition, the optimal noise barrier heights reduce the health damage cost on a nearby region by 8.8% (USD 7213), and the barrier installation cost is also reduced by 0.7% (USD 1409). The proposed method can help the general contractor establish a noise mitigation plan to reduce the health impact of construction noise exposure on nearby residents as well as to prevent additional expenses for disputes or compensations. Furthermore, it can help the government reduce the social cost of solving disputes related to construction noise by providing a quantitative metric for compensation criteria based on the health impact of construction noise exposure. ⓘ Jung, Seunghoon; Kang, Hyuna; Choi, Jinwoo; Hong, Taehoon; Park, Hyo Seon; Lee, Dong-Eun ⓘ Yonsei Univ, Dept Architecture & Architectural Engn, Seoul, South Korea; Kyungpook Natl Univ, Sch Architecture & Civil Engn, Daegu, South Korea ⓘ ; Hong, Taehoon/E-9169-2012 ⓘ 57207940898; 57188750703; 57216361641; 57969349700; 55669886900; 56605563300 ⓘ saber21@yonsei.ac.kr;hyuna_kang@yonsei.ac.kr;jinwoo818@yonsei.ac.kr;hong7@yonsei.ac.kr;hspark@yonsei.ac.kr;dolee@knu.ac.kr; ⓘ BUILDING AND ENVIRONMENT ⓘ BUILD ENVIRON ⓘ 0360-1323 1873-684X 176 SCIE CONSTRUCTION & BUILDING TECHNOLOGY;ENGINEERING, CIVIL;ENGINEERING, ENVIRONMENTAL ⓘ 2020 6.456 4.0 2.19 2025-06-25 ⓘ 40 46 Construction noise; Environmental burden of Disease; Health damage cost; Noise barrier optimization; Quantitative health impact Assessment ⓘ SHAPE OPTIMIZATION; PERFORMANCE; ANNOYANCE; WORKERS ⓘ Construction noise; Environmental burden of Disease; Health damage cost; Noise barrier optimization; Quantitative health impact Assessment ⓘ Acoustic noise measurement; Cost estimating; Health; Noise pollution; Compensation costs; Compensation criteria; Construction noise; Environmental burden of disease; General contractors; Health impact assessment; Installation costs; Quantitative metric; construction industry; health impact; noise pollution; optimization; pollution exposure; quantitative analysis; risk assessment; Cost reduction ⓘ English 2020 2020-06 10.1016/j.buildenv.2020.106869 ⓘ 바로가기 바로가기 바로가기 바로가기
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