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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | Structural orientation effect of cellulose nanocrystals (CNC) films on electrochemical kinetics and stability in lithium-ion batteries | To satisfy the technical requirements of advanced energy storage systems with high energy density, high power density and reliable battery life time, significant efforts have been devoted to material optimization by designing novel metal/carbon composites or metal alloy materials. Different from the previous approaches mainly focused on the composition of active materials, herein, we studied how the structural orientation of carbon precursors can influence the electrochemical kinetics and stability of lithium ion batteries (LiBs). Two differently aligned cellulose nanocrystal (CNC) films - aligned CNC (aCNC) and chiral nematic CNC (nCNC) films) - were fabricated, carbonized and evaluated as anode electrodes for LiBs. The architecture of carbonized aCNC (c-aCNC) provides a favorable pathway for ion/electron transport, resulting in excellent rate retention (40% at 200 mA g(-1)) in comparison with the carbonized nCNC (c-nCNC) (20% at 200 mA g(-1)). In addition, c-aCNC exhibited a more stable cycle performance (92% capacity retention over 450 cycles) than c-nCNC (48% capacity over 450 cycles), owing to the better electrochemical reactions and heat dispersion of c-aCNC than those of c-nCNC. The proposed concept has clearly demonstrated that the electrochemical behaviors of LiBs can be affected by the structural orientation of electrodes. It would possibly bring up more relevant battery researches for follow-up works in the future. | Kim, Kyungho; Kim, Patrick J.; Chowdhury, Reaz Ahmed; Kantharaj, Rajath; Candadai, Aaditya; Marconnet, Amy; Pol, Vilas G.; Youngblood, Jeffrey P. | Purdue Univ, Mat Sci & Engn, W Lafayette, IN 47907 USA; Purdue Univ, Davidson Sch Chem Engn, W Lafayette, IN 47907 USA; Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA; Kyungpook Natl Univ, Dept Appl Chem, Daegu 41566, South Korea | Marconnet, Amy/G-3623-2010 | 57194346355; 57195611779; 56146644100; 57201666928; 56989760500; 8530211200; 7003373214; 15823224800 | jpyoungb@purdue.edu; | CHEMICAL ENGINEERING JOURNAL | CHEM ENG J | 1385-8947 | 1873-3212 | 417 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL | 2021 | 16.744 | 2.5 | 1.44 | 2025-07-30 | 27 | 26 | Cellulose nanocrystals (CNC); Film orientation; Li-ion batteries; Thermal conductivity; Electrochemical kinetics | CARBON ANODE; PERFORMANCE; SODIUM; GRAPHITE; INTERFACE; DENSITY; BIOMASS; STORAGE | Cellulose nanocrystals (CNC); Electrochemical kinetics; Film orientation; Li-ion batteries; Thermal conductivity | Capacity; Cellulose Derivatives; Ions; Lithium Compounds; Orientation; Retention; Stability; Cellulose; Cellulose derivatives; Cellulose films; Cellulose nanocrystals; Electrochemical electrodes; Energy storage; Ions; Lithium compounds; Cellulose nanocrystal (CNC); Electrochemical behaviors; Electrochemical kinetics; Electrochemical reactions; Energy storage systems; High energy densities; Material optimization; Structural orientations; Lithium-ion batteries | English | 2021 | 2021-08-01 | 10.1016/j.cej.2020.128128 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Synergetic enhancement of the energy harvesting performance in flexible hybrid generator driven by human body using thermoelectric and piezoelectric combine effects | Flexible thermoelectric-piezoelectric generator (f-TPEG) has emerged as the leading candidate to realize longterm biomedical monitoring-based ubiquitous healthcare services. We developed a f-TPEG composed of a piezoelectric (PE) poly(vinylidene fluoride-co-trifluoroethylene) thin film and thermoelectric (TE) bismuth telluride-based alloy blocks. The surficial properties of TE and PE components of f-TPEG were thoroughly optimized to minimize the loss of output performance and enhance the mechanical stability. The f-TPEG harvested a maximum electric voltage of -17 V and current signals of -3.8 mu A at a temperature difference of 3 K by periodic bendings: The harvested output power of the fabricated hybrid energy generator was well integrated without sacrificing each PE and TE-based energy generation. In addition, to confirm the biological energy harvesting efficiency of the generator, we demonstrated the f-TPEG taped onto human fingers, which converts an output voltage of about 8 V and a current pulse of about 6 mu A. The results obtained herein suggest that the f-TPEG would play a variety of important roles in wearable device, which needs long-term biomedical monitoring and applications in smart clothing. | Kim, Seoha; Hyeon, Dong Yeol; Ham, Seong Su; Youn, Jimin; Lee, Ho Seong; Yi, Seonghoon; Kim, Kyung Tae; Park, Kwi-Il | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Korea Inst Mat Sci, Powder Mat Div, Chang Won 51508, Gyeongnam, South Korea | Park, Kwiil/LKN-9445-2024; Kim, So-Young/JFS-7698-2023; Yi, Seonghoon/HGC-6912-2022; Hyeon, Dong Yeol/HNR-5711-2023 | 57212495287; 57209099464; 57220094093; 57221833089; 55706810400; 14008383000; 56984373000; 35280874200 | ktkim@kims.re.kr;kipark@knu.ac.kr; | APPLIED SURFACE SCIENCE | APPL SURF SCI | 0169-4332 | 1873-5584 | 558 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, COATINGS & FILMS;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2021 | 7.392 | 2.5 | 1.7 | 2025-07-30 | 24 | 30 | Flexible; Piezoelectric; Thermoelectric; Energy harvester; Self-powered; Hybrid generator | Energy harvester; Flexible; Hybrid generator; Piezoelectric; Self-powered; Thermoelectric | Bismuth alloys; Bismuth compounds; Fluorine compounds; Mechanical stability; Piezoelectric devices; Piezoelectricity; Biomedical monitoring; Energy; Energy Harvester; Flexible; Hybrid generator; Piezoelectric; Piezoelectric generators; Self-powered; Synergetics; Thermoelectric; Energy harvesting | English | 2021 | 2021-08-30 | 10.1016/j.apsusc.2021.149784 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Synthesis and characterization of carbon-coated Cu-Ni alloy nanoparticles and their application in conductive films | In this paper, an efficient fabrication route is presented for carbon-coated Cu-Ni alloy nanoparticles (Cu1-xNix@C NPs; x = 0-1.0) by means of electrical wire explosion under methane gas. The Cu-Ni binary system, which is considered to be an ideal isomorphous system, has carbon growth controllable by tuning the atomic fraction of Cu and Ni with largely different carbon solubility. As the Ni content increases, the average particle size and carbon layer thickness increase. It is notable that the carbon layer is very thin, <2 nm, regardless of the core size for pure Cu@C NPs. On the other hand, as the Ni content increases, the particle size dependence of the carbonlayer thickness becomes significant and the carbon layer is obviously tunable from amorphous to crystalline form. The high-temperature oxidation stability of Cu1-xNix@C NPs is enhanced with increasing Ni content due to the higher thermal stability of carbon layers with greater thickness and high crystallinity. The conductive films were prepared using screen-printing of paste containing Cu1-xNix@C NPs and the electrical resistivity was mapped according to the Ni content. The temperature stability of the sheet resistance and activation energy of oxidation for the conductive films increase with increasing Ni content. | Lee, Gyoung-Ja; Lee, Jun-Hyeok; Lee, Dongju; Park, Kwi-Il; Jeong, Chang Kyu; Park, Jin-Ju; Lee, Min-Ku | Korea Atom Energy Res Inst, Smart Struct Safety & Prognosis Res Div, Daejeon 34057, South Korea; Korea Evaluat Inst Ind Technol, Market Cooperat Team, Daegu 41069, South Korea; Chungbuk Natl Univ, Dept Adv Mat Engn, Dept Urban Energy & Environm Engn, Chungdae Ro 1, Cheongju 28644, Chungbuk, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, 80 Daehak Ro, Daegu 41566, South Korea; Jeonbuk Natl Univ, Div Adv Mat Engn, 567 Baekje Daero, Jeonju 54896, Jeonbuk, South Korea | Jeong, Chang Kyu/ADT-8127-2022; Park, Kwiil/LKN-9445-2024 | 8588965200; 57226273268; 57210700643; 35280874200; 55961876600; 24399310900; 59302175900 | leeminku@kaeri.re.kr; | APPLIED SURFACE SCIENCE | APPL SURF SCI | 0169-4332 | 1873-5584 | 566 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, COATINGS & FILMS;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2021 | 7.392 | 2.5 | 1.68 | 2025-07-30 | 27 | 26 | Cu-Ni alloy nanoparticles; Carbon coating; Core-shell structure; Conductive film; Temperature stability | ELECTRICAL-RESISTIVITY; MAGNETIC-PROPERTIES; NANO-PARTICLES; GRAPHENE; POWDERS; FABRICATION; GROWTH | Carbon coating; Conductive film; Core-shell structure; Cu-Ni alloy nanoparticles; Temperature stability | Activation energy; Amorphous carbon; Carbon films; Copper alloys; Crystallinity; Nanoparticles; Nickel alloys; Particle size; Screen printing; Synthesis (chemical); Thermodynamic stability; Thermooxidation; Alloy nanoparticle; Carbon coating; Carbon layers; Carbon-coated; Core shell structure; Cu-ni alloy nanoparticle; CuNi alloy; Layer thickness; Ni content; Temperature stability; Binary alloys | English | 2021 | 2021-11-15 | 10.1016/j.apsusc.2021.150672 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | UV curable ionogel for all-solid-state supercapacitor | An ionogel electrolyte with polyurethane acrylate (PUA) and 1-ethyl-3-methyl imidazolium bis(trifluoromethylsulfonyl)imide (EMITFSI) is proposed as an all-solid-state supercapacitor operating at 4 V. The ionogel-based electrolyte is manufactured by using a solvent-free in-situ polymerization method. The ratio of EMITFSI to PUA is optimized by maintaining the free-standing membrane and high ionic conductivity. The supercapacitor, which comprises 25 wt% PUA and 75 wt% EMITFSI, exhibits the highest specific capacitance of 150.88 F g-1 at 0.1 A g-1. It also possesses a high specific energy density (93.93 W h kg-1) without sacrificing specific power density (2000.96 W kg-1) at 0.5 A g-1. Furthermore, the ionogel-applied supercapacitor maintains 99% of its specific capacitance (Cs) after 1000 cycles and exhibits remarkable flexibility while maintaining 92% of its Cs after bending 100 times. Superscript/Subscript Available</comment | Han, Juyeon; Choi, Youngkyu; Lee, Junyeong; Pyo, Seonmi; Jo, Sungjin; Yoo, Jeeyoung | Kyungpook Natl Univ, Sch Energy Engn, Daegu 41566, South Korea; Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Program Nano Sci & Technol, Gwanak Ro 1, Seoul 08826, South Korea | Yoo, Jeeyoung/AAH-1359-2019 | 57222146622; 57222156597; 58853044900; 57211858131; 7101724027; 56046607500 | jyoo@knu.ac.kr; | CHEMICAL ENGINEERING JOURNAL | CHEM ENG J | 1385-8947 | 1873-3212 | 416 | SCIE | ENGINEERING, CHEMICAL;ENGINEERING, ENVIRONMENTAL | 2021 | 16.744 | 2.5 | 1.83 | 2025-07-30 | 38 | 41 | Solvent-free; UV-curable; Ionogel electrolyte; Flexible supercapacitor | IONIC LIQUIDS; POLYMER ELECTROLYTES; GEL POLYMER; NANOPARTICLES; TEMPERATURE; PERFORMANCE; CARBON | Flexible supercapacitor; Ionogel electrolyte; Solvent-free; UV-curable | Capacitance; Curing; Electrolytes; All-solid-state supercapacitors; Free standing membranes; In-situ polymerization; Polyurethane acrylates; Solvent free; Specific capacitance; Specific energy density; Specific power; Supercapacitor | English | 2021 | 2021-07-15 | 10.1016/j.cej.2021.129089 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Van der Waals heterojunction interface passivation using ZnS nanolayer and enhanced photovoltaic behavior of semitransparent ultrathin 2D-MoS2/3D-chalcogenide solar cells | Along with highly efficient Cu(In1-x,Ga-x)Se-2 (CIGSe)-based thin-film solar cells, versatile solar cells are urgently required to meet a variety of functional needs, such as photovoltaic (PV) power conversion, transparency, ultrathinness, and light weight. To meet these needs, a semitransparent ultrathin (STUT) CIGSe solar cell with two-dimensional (2D) transition metal dichalcogenide (TMD) as the buffer layer is proposed as a prospective next-generation solar cell structure that exhibits advantages based on both the distinguishable optical properties of 2D TMDs and the high efficiency of CIGSe-based solar cells. However, the application of 2D TMDs on top of CIGSe is challenging because the surface of 2D TMDs is nominally and supposedly flat and smooth, while that of CIGSe absorbers is typically rough, and their combination is prone to defect formation at the interface. To overcome degradation due to interfacial defects, a 2D-MoS2/ZnS/CIGSe semitransparent ultrathin solar cell was designed by inserting a ZnS nanolayer for heterojunction interface passivation, and the photovoltaic properties of the device were found to be improved. Furthermore, based on the binding energies of each layer, the energy band structures of n-MoS2/p-CIGSe with and without a ZnS passivation layer are suggested, and the related implications for device performance are discussed. | Park, Joo Hyung; Kim, Dongryeol; Shin, Sang Su; Jo, Yonghee; Cho, Jun-Sik; Park, Jonghoo; Kim, TaeWan | Korea Inst Energy Res KIER, Photovolta Res Dept, Daejeon 34129, South Korea; Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Kyungpook Natl Univ, Dept Elect Engn, Daegu 41566, South Korea; Jeonbuk Natl Univ, Dept Elect Engn, Jeonju 54896, South Korea; Jeonbuk Natl Univ, Smart Grid Res Ctr, Jeonju 54896, South Korea | Park, Joo Hyung/AAL-5247-2020 | 57193059568; 57194069208; 57217686358; 57646774900; 7403535861; 57196408322; 57199878285 | joopark@kier.re.kr;twkim@jbnu.ac.kr; | APPLIED SURFACE SCIENCE | APPL SURF SCI | 0169-4332 | 1873-5584 | 558 | SCIE | CHEMISTRY, PHYSICAL;MATERIALS SCIENCE, COATINGS & FILMS;PHYSICS, APPLIED;PHYSICS, CONDENSED MATTER | 2021 | 7.392 | 2.5 | 0.81 | 2025-07-30 | 12 | 12 | ZnS passivation; 2D MoS2; Ultrathin Cu(In,Ga)Se-2; van der Waals junction; Semitransparent solar cell | THIN-FILMS; SURFACE PASSIVATION; MONOLAYER MOS2; LAYER; EFFICIENT; CONTACTS; SILICON | 2D MoS<sub>2</sub>; Semitransparent solar cell; Ultrathin Cu(In,Ga)Se<sub>2</sub>; van der Waals junction; ZnS passivation | Binding energy; Buffer layers; Heterojunctions; Layered semiconductors; Molybdenum compounds; Optical properties; Passivation; Photovoltaic effects; Selenium compounds; Solar cells; Solar power generation; Transition metals; Van der Waals forces; Zinc sulfide; 2d MoS2; Heterojunction interfaces; Interface passivation; MoS$-2$; Nano layers; Semi-transparent solar cells; Ultra-thin; Ultrathin cu(in,ga)se2; Van der waal junction; ZnS passivation; II-VI semiconductors | English | 2021 | 2021-08-30 | 10.1016/j.apsusc.2021.149844 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone-graft substitute for accelerated craniofacial bone regeneration | Background: Bioceramic beta-tricalcium phosphate (beta-TCP) is used as a bone-grafting material and a therapeutic drug carrier for treatment of bone defects in the oral and maxillofacial regions due to the osteoconductivity and biocompatibility. However, the low mechanical strength and limited osteoinductivity of beta-TCP agglomerate restrict bone regenerating performance in clinical settings. Methods: Herein, a biomimetic composite is proposed as a bone morphogenetic protein-2 (BMP-2)-delivering bone graft substitute to achieve a robust bone grafting and augmented bone regeneration. Results: The sequential processes of brown algae-inspired biosilicification and collagen coating on the surface of beta TCP enable the effective incorporation of BMP-2 into the coating layer without losing its bioactivity. The sustained delivery of BMP-2 from the biosilicated collagen and beta-TCP composites promoted in vitro osteogenic behaviors of pre-osteoblasts and remarkedly accelerated in vivo bone regeneration within a rat calvarial bone defect. Conclusions: Our multicomposite bone substitutes can be practically applied to improve bone tissue growth in bone grafting applications with further expansion to general bone tissue engineering. | Lee, Dong Keon; Ki, Mi-Ran; Kim, Euy Hyun; Park, Chang-Joo; Ryu, Jae Jun; Jang, Hyon Seok; Pack, Seung Pil; Jo, Yun Kee; Jun, Sang Ho | Korea Univ, Dept Oral & Maxillofacial Surg, Anam Hosp, Seoul 02841, South Korea; Korea Univ, Dept Biotechnol & Bioinformat, Sejong 30019, South Korea; Hanyang Univ, Div Oral & Maxillofacial Surg, Dept Dent, Coll Med, Seoul 04763, South Korea; Korea Univ, Dept Prosthodont, Anam Hosp, Seoul 02841, South Korea; Korea Univ, Ansan Hosp, Dept Oral & Maxillofacial Surg, Ansan 15355, South Korea; Kyungpook Natl Univ, Sch Convergence, Dept Biomed Convergence Sci & Technol, Daegu 41566, South Korea; Kyungpook Natl Univ, Cell & Matrix Res Inst, Daegu 41566, South Korea | Jun, Sang Ho/LCE-7830-2024; Ryu, Jae-Jun/AAL-6362-2020 | 57204776868; 10540618000; 57223039627; 56140949900; 13003243900; 7202133274; 9738989800; 56123757800; 35114981500 | spack@korea.ac.kr;ykjo@knu.ac.kr;junsang@korea.ac.kr; | BIOMATERIALS RESEARCH | BIOMATER RES | 1226-4601 | 2055-7124 | 25 | 1 | SCIE | ENGINEERING, BIOMEDICAL;MATERIALS SCIENCE, BIOMATERIALS | 2021 | 15.863 | 2.6 | 2.33 | 2025-07-30 | 34 | 40 | Osteoinductive bone substitute; Collagen/beta-TCP composite; Biosilicification; Bone morphogenetic protein-2 (BMP-2); Biomimetic materials | AUTOGENOUS BONE; SCAFFOLDS; DIFFERENTIATION; HYDROXYAPATITE; DELIVERY | Biomimetic materials; Biosilicification; Bone morphogenetic protein-2 (BMP-2); Collagen/β-TCP composite; Osteoinductive bone substitute | biomimetic material; bone morphogenetic protein 2; bone sialoprotein; calcium phosphate; collagen; osteocalcin; recombinant bone morphogenetic protein 2; silicate; animal cell; animal experiment; animal model; animal tissue; Article; biological activity; biomimetics; bone development; bone graft; bone growth; bone matrix; bone maturation; bone regeneration; bone remodeling; bone tissue; bone volume fraction; brown alga; calvaria; cell differentiation; cell viability; coating (procedure); collagen fiber; compressive strength; controlled study; drug delivery system; Ectocarpus siliculusus; fracture healing rate; gene expression level; in vitro study; in vivo study; male; micro-computed tomography; mouse; nonhuman; ossification; osteoblast; rat; skull defect; surface property; sustained drug release; tissue engineering; upregulation | English | 2021 | 2021-04-21 | 10.1186/s40824-021-00214-w | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Gamma subunit of complement component 8 is a neuroinflammation Inhibitor | The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages. The majority of these complement components, such as components 3a (C3a) and C5a, are chemotactic and pro-inflammatory. However, in this study, we revealed an inhibitory role of complement component 8 gamma (C8G) in neuroinflammation. In patients with Alzheimer's disease, who exhibit strong neuroinflammation, we found higher C8G levels in brain tissue, CSF, and plasma. Our novel findings also showed that the expression level of C8G increases in the inflamed mouse brain, and that C8G is mainly localized to brain astrocytes. Experiments using recombinant C8G protein and shRNA-mediated knockdown showed that C8G inhibits glial hyperactivation, neuroinflammation, and cognitive decline in acute and chronic animal models of Alzheimer's disease. Additionally, we identified sphingosine-1-phosphate receptor 2 (S1PR2) as a novel interaction protein of C8G and demonstrated that astrocyte-derived C8G interacts with S1PR2 to antagonize the pro-inflammatory action of S1P in microglia. Taken together, our results reveal the previously unrecognized role of C8G as a neuroinflammation inhibitor. Our findings pave the way towards therapeutic containment of neuroinflammation in Alzheimer's disease and related neurological diseases. | Kim, Jong-Heon; Afridi, Ruqayya; Han, Jin; Jung, Hyun-Gug; Kim, Seung-Chan; Hwang, Eun Mi; Shim, Hyun Soo; Ryu, Hoon; Choe, Youngshik; Hoe, Hyang-Sook; Suk, Kyoungho | Kyungpook Natl Univ, Brain Sci & Engn Inst, Daegu, South Korea; Kyungpook Natl Univ, Sch Med, Dept Pharmacol, 680 Gukchaebosang St, Daegu 41944, South Korea; Kyungpook Natl Univ, Sch Med, Dept Biomed Sci, Daegu, South Korea; Korea Inst Sci & Technol, Brain Sci Inst, Ctr Neuromed & Neurosci, Seoul, South Korea; Korea Univ, Coll Hlth Sci, Sch Biosyst & Biomed Sci, Seoul, South Korea; VA Boston Healthcare Syst, Boston, MA USA; Boston Univ, Alzheimers Dis Ctr, Boston, MA 02215 USA; Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA; Korea Brain Res Inst, Daegu, South Korea | ; Ryu, Hoon/MCJ-9411-2025; Hwang, Eun Mi/HHN-3030-2022; Kim, Hyun Jung/GQP-3241-2022 | 57203324811; 57200759784; 57218360938; 56179534300; 57204605658; 7101826741; 59580702300; 7202277209; 22833254300; 8948946800; 7005114595 | ksuk@knu.ac.kr; | BRAIN | BRAIN | 0006-8950 | 1460-2156 | 144 | 2 | SCIE | CLINICAL NEUROLOGY;NEUROSCIENCES | 2021 | 15.255 | 2.6 | 3.03 | 2025-07-30 | 36 | 35 | neuroinflammation; astrocytes; complement component 8 gamma; microglia; sphingosine-1-phosphate receptor 2 | SPHINGOSINE-1-PHOSPHATE RECEPTOR 2; SPHINGOSINE 1-PHOSPHATE COUNTERACTS; FLUORO-JADE-C; NF-KAPPA-B; MICROGLIAL ACTIVATION; ALZHEIMERS-DISEASE; TNF-ALPHA; PROTEIN-SYNTHESIS; MURINE MICROGLIA; INNATE IMMUNITY | astrocytes; complement component 8 gamma; microglia; neuroinflammation; sphingosine-1-phosphate receptor 2 | Alzheimer Disease; Animals; Astrocytes; Cells, Cultured; Complement C8; Encephalitis; Male; Mice, Inbred C57BL; Microglia; Protein Subunits; Sphingosine-1-Phosphate Receptors; antiinflammatory agent; complement component C8; gamma interferon; interleukin 10; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; recombinant complement component 8 gamma; recombinant protein; sphingosine 1 phosphate receptor; sphingosine 1 phosphate receptor 2; tumor necrosis factor; unclassified drug; complement component C8; sphingosine-1-phosphate receptor-2, mouse; 5xFAD mouse; adult; affinity purification; Alzheimer disease; amino terminal sequence; amyloid plaque; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; astrocyte; astrocytosis; Barnes maze test; BV-2 cell line; cell activation; coimmunoprecipitation; complement system; controlled study; cytokine production; depression; embryo; gene knockdown; gliosis; hippocampal CA3 region; hippocampal neuronal culture; human; human cell; image analysis; immunohistochemistry; immunopharmacology; immunoreactivity; latent period; learning and memory test; lipopolysaccharide-induced neuroinflammation; male; mass spectrometry; memory disorder; mouse; mRNA expression level; nerve degeneration; neuroprotection; neurotoxicity; nonhuman; protein expression level; real time reverse transcription polymerase chain reaction; sandwich ELISA; upregulation; Alzheimer disease; animal; C57BL mouse; cell culture; cerebrospinal fluid; complication; encephalitis; immunology; microglia; protein subunit | English | 2021 | 2021-03-03 | 10.1093/brain/awaa425 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Short-term outcomes of a multicentre randomized clinical trial comparing laparoscopic pylorus-preserving gastrectomy with laparoscopic distal gastrectomy for gastric cancer (the KLASS-04 trial) | Background: There remain concerns about the safety and functional benefit of laparoscopic pylorus-preserving gastrectomy (LPPG) compared with laparoscopic distal gastrectomy (LDG). This study evaluated short-term outcomes of a randomized clinical trial (RCT) comparing LPPG with LDG for gastric cancer. Methods: The Korean Laparoendoscopic Gastrointestinal Surgery Study (KLASS)-04 trial was an investigator-initiated, open-label, parallel-assigned, superiority, multicentre RCT in Korea. Patients with cT1N0M0 cancer located in the middle third of the stomach at least 5 cm from the pylorus were randomized to undergo LPPG or LDG. Participants, care givers and those assessing the outcomes were not blinded to group assignment. Outcomes were 30-day postoperative morbidity rate and death at 90 days. Results: Some 256 patients from nine institutions were randomized (LPPG 129 patients, LDG 127 patients) between July 2015 and July 2017 and outcomes for 253 patients were analysed. Postoperative complications within 30 days were seen in 19.3 and 15.5 per cent in the LPPG and LDG groups respectively (P = 0.419). Postoperative pyloric stenosis was observed in nine (7.2 per cent) and two (1.5 per cent) patients in the LPPG and LDG groups (P = 0.026) respectively. In multivariable analysis higher BMI was a risk factor for postoperative complications (odds ratio 1.17, 95 per cent c.i. 1.04 to 1.32; P = 0.011). Death at 90 days was zero in both groups. Conclusion: Postoperative complications and mortality was comparable in patients undergoing LPPG and LDG. | Park, D. J.; Kim, Y-W; Yang, H-K; Ryu, K. W.; Han, S-U; Kim, H-H; Hyung, W-J; Park, J. H.; Suh, Y-S; Kwon, O. K.; Yoon, H. M.; Kim, W.; Park, Y-K; Kong, S-H; Ahn, S. H.; Lee, H-J | Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Surg, Coll Med, Seoul, South Korea; Seoul Natl Univ, Seoul Natl Univ Hosp, Canc Res Inst, Coll Med, Seoul, South Korea; Seoul Natl Univ, Bundang Hosp, Dept Surg, Coll Med, Seongnam, South Korea; Natl Canc Ctr, Dept Surg, Goyang, South Korea; Ajou Univ Hosp, Dept Surg, Suwon, South Korea; Yonsei Univ, Dept Surg, Severance Hosp, Seoul, South Korea; Gyeongsang Natl Univ Hosp, Dept Surg, Daegu, South Korea; Kyungpook Natl Univ Hosp, Dept Surg, Daegu, South Korea; Catholic Univ Korea, Dept Surg, Yeouido St Marys Hosp, Seoul, South Korea; Chonnam Natl Univ, Dept Surg, Med Sch, Hwasun, South Korea | 김, 수중/JED-7162-2023; Kong, Sung/AAJ-7808-2020; Kim, Hyung-Ho/HZM-2707-2023; SANG-HOON, AHN/AAV-2600-2020; Yang, Han-Kwang/J-2767-2012 | 14319341400; 57215377843; 7406557280; 55667555300; 35798267700; 47962218500; 6602139318; 57202928322; 39062470900; 26536109900; 35735626600; 57219776830; 10140547300; 55641926600; 55838509518; 7501481303 | appe98@snu.ac.kr; | BRITISH JOURNAL OF SURGERY | BRIT J SURG | 0007-1323 | 1365-2168 | 108 | 9 | SCIE | SURGERY | 2021 | 11.782 | 2.6 | 5.79 | 2025-07-30 | 58 | 49 | RISK-FACTORS; CRITERIA; STOMACH | Adult; Aged; Aged, 80 and over; Female; Follow-Up Studies; Gastrectomy; Humans; Laparoscopy; Male; Middle Aged; Neoplasm Staging; Pylorus; Retrospective Studies; Stomach Neoplasms; Time Factors; Treatment Outcome; Young Adult; albumin; transferrin; tumor marker; adult; aged; Article; balloon dilatation; blood cell count; blood vessel injury; body mass; cancer mortality; cancer staging; cancer surgery; clinical assessment; computer assisted tomography; controlled study; device safety; echography; endoscopic ultrasonography; esophagogastroduodenoscopy; female; gastrectomy; gastroesophageal junction; gastrointestinal surgery; gastrojejunostomy; gastroscopy; histology; human; human tissue; laparoscopic distal gastrectomy; laparoscopic pylorus preserving gastrectomy; laparotomy; liver function test; lymph node dissection; major clinical study; male; morbidity; mortality; multicenter study; omentectomy; open surgery; outcome assessment; pancreas fistula; postoperative complication; postoperative period; pylorus; pylorus stenosis; quality control; randomized controlled trial; risk factor; stomach adenocarcinoma; stomach biopsy; stomach cancer; vagus nerve; clinical trial; follow up; gastrectomy; laparoscopy; middle aged; procedures; pylorus; retrospective study; stomach tumor; time factor; treatment outcome; very elderly; young adult | English | 2021 | 2021-09-27 | 10.1093/bjs/znab295 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Editorial Material | Timing and clinical outcomes of tracheostomy in patients with COVID-19 | Ahn, D.; Lee, G. J.; Choi, Y. S.; Park, J. W.; Kim, J. K.; Kim, E. J.; Lee, Y. H. | Kyungpook Natl Univ, Dept Otolaryngol Head & Neck Surg, Daegu, South Korea; Yeungnam Univ, Dept Otolaryngol Head & Neck Surg, 170 Hyeonchungro, Daegu 42415, South Korea; Keimyung Univ, Dept Otolaryngol Head & Neck Surg, Daegu, South Korea; Catholic Univ Daegu, Dept Otolaryngol Head & Neck Surg, Daegu, South Korea; Catholic Univ Daegu, Div Pulm & Crit Care Med, Dept Internal Med, Duryugongwon Ro 17 Gil 33, Daegu 42472, South Korea; Kyungpook Natl Univ, Div Pulm & Crit Care Med, Dept Internal Med, Daegu, South Korea | Kim, Eun/AAS-6706-2020; Kim, Eun Jin/L-6480-2018; Choi, Yoon Seok/JXL-3789-2024 | 44761055400; 57193082568; 56139995900; 55717085400; 57204123579; 55927957400; 57199022948 | choiys@ynu.ac.kr;ejkim77@cu.ac.kr; | BRITISH JOURNAL OF SURGERY | BRIT J SURG | 0007-1323 | 1365-2168 | 108 | 1 | SCIE | SURGERY | 2021 | 11.782 | 2.6 | 8.21 | 2025-07-30 | 10 | 11 | Adult; Aged; Aged, 80 and over; COVID-19; Critical Care; Humans; Infectious Disease Transmission, Patient-to-Professional; Middle Aged; Postoperative Complications; Republic of Korea; SARS-CoV-2; Time-to-Treatment; Tracheostomy; Treatment Outcome; bleeding; clinical outcome; coronavirus disease 2019; epidemic; follow up; hospital mortality; hospitalization; human; intubation; length of stay; Letter; mortality rate; outcome assessment; questionnaire; risk factor; trachea stenosis; tracheostomy; virus transmission; adult; adverse event; aged; disease transmission; epidemiology; intensive care; middle aged; postoperative complication; prevention and control; procedures; South Korea; time to treatment; treatment outcome; very elderly | English | 2021 | 2021-01 | 10.1093/bjs/znaa064 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Review | Application of plant mucilage polysaccharides and their techno-functional properties' modification for fresh produce preservation | The use of edible coating/film to improve fresh produce's quality and shelf life is an old but reliable and popular method of preservation. Recently, plant-derived mucilages have been extensively used to prepare edible packages (MEPs). This review focuses on recent studies that characterize mucilages from different plants, and examine their specific applications as edible packages in preserving fruits and vegetables. Structure-function relations and corresponding influence on film-forming properties are discussed. This review also surveys the additive-modifications of MEPs techno-functional properties. MEPs from a range of plant sources are effective in preventing quality loss and improving the storability of various fruits and vegetables. The preservative mechanisms and essential techno-functional properties of MEPs required for fruit and vegetable packaging were summarized. The key findings summarized in this study will help promote the utilization of mucilages and draw attention to other novel applications of this valuable polymer. | Olawuyi, Ibukunoluwa Fola; Kim, Soo Rin; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Kim, Soo Rin/X-2192-2019; Olawuyi, Ibukunoluwa/H-1232-2018; Lee, Wonyoung/AAL-2780-2021 | 57204471854; 36659584200; 57195940408 | ifolawuyi@knu.ac.kr;wonyoung@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 272 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2021 | 10.723 | 2.7 | 0.78 | 2025-07-30 | 34 | 38 | Mucilage polysaccharides; Edible package; Techno-functional properties; Fruits and vegetable | ALOE-VERA GEL; BIODEGRADABLE EDIBLE FILM; FICUS-INDICA MUCILAGE; BASIL-SEED GUM; SALVIA-HISPANICA L.; SHELF-LIFE; ESSENTIAL OIL; PHYSICOCHEMICAL CHARACTERIZATION; GLYCEROL CONCENTRATION; CHEMICAL-COMPOSITION | Edible package; Fruits and vegetable; Mucilage polysaccharides; Techno-functional properties | Edible Films; Food Packaging; Food Preservation; Food Preservatives; Fruit; Plant Mucilage; Plants; Polysaccharides; Solubility; Vegetables; Polysaccharides; Vegetables; food preservative; polysaccharide; Coating films; Edible coating; Edible package; Fresh produce; Fruit and vegetables; Functional properties; Mucilage polysaccharide; Quality life; Shelf life; Techno-functional property; chemistry; food packaging; food preservation; fruit; mucilage; plant; procedures; solubility; vegetable; Fruits | English | 2021 | 2021-11-15 | 10.1016/j.carbpol.2021.118371 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Cellulose nanocrystal preparation from Gelidium amansii and analysis of its anti-inflammatory effect on the skin in vitro and in vivo | Treated Gelidium amansii cellulose nanocrystal (TGa CNC) was prepared from treated Gelidium amansii (TGa) and evaluated for its anti-inflammatory effect on human keratinocytes and mice skin. Using three independent cell lines, TGa CNC showed no cytotoxicity in HaCaT, Beas-2B, and Raw 264.7 cells. A non-toxic dose of TGa CNC suppressed ultraviolet (UV) B-induced AP (activated protein)-1, and subsequent cyclooxygenase (COX)-2 gene and protein expression in HaCaT cells. TGa CNC suppressed translocation of c-Jun from the cytosol to the nucleus responds to UVB irradiation. Additionally, TGa CNC suppressed UVB-induced extracellular signal-regulated kinases (ERKs)1/2/MEK/2/B-Raf, c-Jun N-terminal kinase (JNK)1/2/MKK4/7, Akt, and epidermal growth factor receptor (EGFR) phosphorylation in HaCaT cells. Dorsal treatment of TGa CNC significantly suppressed acute UVB-induced increase in epidermal thickness and COX-2 expression in mice skin. Overall, these results indicate that TGa CNC exerts potent anti-inflammatory activity through the inhibition of abnormal COX-2 expression and mitogen-activated protein kinases (MAPK)s signaling pathways. | So, Bo Ram; Yeo, Hyeon Jin; Lee, Jeong Jae; Jung, Young Hoon; Jung, Sung Keun | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea; Chungnarn Natl Univ, Div Anim & Dairy Sci, Daejeon 34134, South Korea; Kyungpook Natl Univ, Inst Agr Sci & Technol, Daegu 41566, South Korea | Jung, Young/F-1703-2013; Jung, SUNG KEUN/AGR-2623-2022 | 57218122440; 57208240157; 55915465100; 55550063700; 35310491400 | younghoonjung@knu.ac.kr;skjung04@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 254 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2021 | 10.723 | 2.7 | 2.1 | 2025-07-30 | 26 | 29 | Cel; Lulose nanocrystal; Gelidium amansiicosmetic ingredient; Anti-skin inflammation; COX-2 | CARBOHYDRATE-BINDING MODULES; COX-2 EXPRESSION; CYCLOOXYGENASE-2; MECHANISM; CRYSTAL; FAMILY; CANCER; ROLES; AP-1 | Anti-skin inflammation; Cel; COX-2; Gelidium amansiicosmetic ingredient; Lulose nanocrystal | Cells; Cellulose Derivatives; Enzymes; Mammals; Radiation Effects; Animals; Anti-Inflammatory Agents; Cell Survival; Cellulose; Cyclooxygenase 2; HaCaT Cells; Humans; Keratinocytes; Male; Mice; Mice, Inbred ICR; Nanoparticles; Plant Extracts; RAW 264.7 Cells; Rhodophyta; Signal Transduction; Skin; Ultraviolet Rays; Cell culture; Cellulose; Cellulose derivatives; Irradiation; Mammals; antiinflammatory agent; cellulose; cyclooxygenase 2; nanoparticle; plant extract; PTGS2 protein, human; Ptgs2 protein, mouse; Anti-inflammatory effects; Anti-skin inflammation; Cel; Cyclooxygenase 2; Gelidium; Gelidium amansii; Gelidium amansiicosmetic ingredient; Lulose nanocrystal; Mouse skin; Nanocrystal preparation; animal; cell survival; chemistry; drug effect; HaCat cell line; human; Institute for Cancer Research mouse; keratinocyte; male; metabolism; mouse; RAW 264.7 cell line; red alga; signal transduction; skin; ultraviolet radiation; Nanocrystals | English | 2021 | 2021-02-15 | 10.1016/j.carbpol.2020.117315 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Covalent immobilization of bromocresol purple on cellulose nanocrystals for use in pH-responsive indicator films | This study developed pH-indicator films by combining esterified cellulose nanocrystals (e-CNCs) with activated bromocresol purple (a-BCP) via covalent bonding for pH-sensitive color-changing applications. The e-CNC/a-BCP particles were incorporated into cellulose acetate polymer to prepare pH-sensitive color changing films. Binding of a-BCP to e-CNCs was proven by attenuated total reflection infrared (ATR-IR) spectroscopy and X-ray photoelectron spectroscopy (XPS). Colorimetric analysis showed that films containing 10% or 15% e-CNC/a-BCP particles had critical color changes either at pH 4-5, or pH 7-8. The films with 10% e-CNC/a-BCP particles also revealed excellent leaching resistance under acidic conditions. Color changes were reversible between pH 2 and 10. These pH-indicator films had visible color changes in response to pH variations, color reversibility, leaching resistance, and sufficient rigidity even though mechanical properties decreased as the e-CNC/a-BCP content increased from 0% to 15%. | Khanjanzadeh, Hossein; Park, Byung-Dae | Kyungpook Natl Univ, Dept Wood & Paper Sci, Daegu 41566, South Korea | ; Park, Byung-Dae/ABB-1934-2020; Khanjanzadeh, Hossein/B-7794-2018 | 37048874200; 7402834820 | byungdae@knu.ac.kr; | CARBOHYDRATE POLYMERS | CARBOHYD POLYM | 0144-8617 | 1879-1344 | 273 | SCIE | CHEMISTRY, APPLIED;CHEMISTRY, ORGANIC;POLYMER SCIENCE | 2021 | 10.723 | 2.7 | 3.57 | 2025-07-30 | 52 | 57 | Cellulose nanocrystals; Bromocresol purple; pH-indicator films; Color changing films; Reversibility | AMMONIUM PERSULFATE; SURFACE; ACID; NANOPARTICLES; COMPOSITES; OXIDATION; GREEN; ESTERIFICATION; ANTHOCYANINS; NANOFIBRILS | Bromocresol purple; Cellulose nanocrystals; Color changing films; pH-indicator films; Reversibility | Cellulose Derivatives; Colorimetry; Esca; Leaching; X Ray Spectroscopy; Cellulose; Cellulose derivatives; Cellulose films; Colorimetry; Leaching; Nanocrystals; pH; Polymer films; X ray photoelectron spectroscopy; Bromocresol purples; Color changes; Color changing; Color changing film; Indicator films; Leaching resistance; pH indicators; pH sensitive; Ph-indicator film; Reversibility; Color | English | 2021 | 2021-12-01 | 10.1016/j.carbpol.2021.118550 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | FoxO1 as a Regulator of Aquaporin 5 Expression in the Salivary Gland | Forkhead box O1 (FoxO1) is a multifunctional initiator, mediator, and repressor of autoimmune diseases in an organ- or disease-specific manner. However, the role of FoxO1 in the salivary gland has not yet been elucidated. In this study, we discovered that FoxO1 and aquaporin 5 (AQP5) are both significantly downregulated in the patients with primary Sjogren syndrome, an autoimmune disease accompanying salivary gland dysfunction. Pharmacologic or genetic perturbation of FoxO1 in the rat salivary gland acinar cell line, SMG-C6, induced a significant downregulation of AQP5 expression, as observed in clinical specimens. There was a strong correlation between FoxO1 and AQP5 expression because FoxO1 is a direct regulator of AQP5 expression in salivary gland acinar cells through its interaction with the promoter region of AQP5. Serial injection of a FoxO1 inhibitor into mice induced a reduction of AQP5 expression in submandibular glands and, consequently, hyposalivation, which is one of the major clinical symptoms of primary Sjogren syndrome. However, there was no sign of inflammation or cell damage in the submandibular glands harvested from mice treated with the FoxO1 inhibitor. In conclusion, our findings indicate that FoxO1 in salivary gland tissue acts as a direct regulator of AQP5 expression. Thus, downregulation of FoxO1 observed in primary Sjogren syndrome is a putative mechanism for hyposalivation without the involvement of previously reported soluble factors in primary Sjogren syndrome patient sera. | Lee, S. M.; Lee, S. W.; Kang, M.; Choi, J. K.; Park, K.; Byun, J. S.; Kim, D. Y. | Kyungpook Natl Univ, Sch Dent, Dept Pharmacol, Daegu 41940, South Korea; Seoul Natl Univ, Sch Dent, Dept Physiol, 28 Yeongun, Seoul 110749, South Korea; Seoul Natl Univ, Dent Res Inst, Seoul, South Korea; Kyungpook Natl Univ, Sch Dent, Dept Oral Med, Daegu 41940, South Korea | ; Kim, Do-Yeon/AET-3021-2022 | 57213176293; 57219301095; 57204540968; 7501395602; 7408065330; 55430621800; 57203012542 | kppark@snu.ac.kr;jsbyun@knu.ac.kr;dykim82@knu.ac.kr; | JOURNAL OF DENTAL RESEARCH | J DENT RES | 0022-0345 | 1544-0591 | 100 | 11 | SCIE | DENTISTRY, ORAL SURGERY & MEDICINE | 2021 | 8.924 | 2.7 | 1.3 | 2025-07-30 | 8 | 9 | Sjogren syndrome; AQP5; xerostomia; submandibular gland; transcriptional factor; acinar cells | SJOGRENS-SYNDROME; CLASSIFICATION CRITERIA; FORKHEAD; AUTOANTIBODIES; FKHR | acinar cells; AQP5; Sjögren syndrome; submandibular gland; transcriptional factor; xerostomia | Animals; Aquaporin 5; Forkhead Box Protein O1; Humans; Mice; Nerve Tissue Proteins; Rats; Salivary Glands; Sjogren's Syndrome; Submandibular Gland; Xerostomia; aquaporin 5; FOXO1 protein, human; Foxo1 protein, mouse; Foxo1 protein, rat; nerve protein; transcription factor FKHR; animal; genetics; human; mouse; rat; salivary gland; Sjoegren syndrome; submandibular gland; xerostomia | English | 2021 | 2021-10 | 10.1177/00220345211003490 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Genomic and anatomical comparisons of skin support independent adaptation to life in water by cetaceans and hippos | The macroevolutionary transition from terra firma to obligatory inhabitance of the marine hydrosphere has occurred twice in the history of Mammalia: Cetacea and Sirenia. In the case of Cetacea (whales, dolphins, and porpoises), molecular phylogenies provide unambiguous evidence that fully aquatic cetaceans and semiaquatic hippopotamids (hippos) are each other's closest living relatives. Ancestral reconstructions suggest that some adaptations to the aquatic realm evolved in the common ancestor of Cetancodonta (Cetacea + Hippopotamidae). An alternative hypothesis is that these adaptations evolved independently in cetaceans and hippos. Here, we focus on the integumentary system and evaluate these hypotheses by integrating new histological data for cetaceans and hippos, the first genome-scale data for pygmy hippopotamus, and comprehensive genomic screens and molecular evolutionary analyses for protein-coding genes that have been inactivated in hippos and cetaceans. We identified eight skin-related genes that are inactivated in both cetaceans and hippos, including genes that are related to sebaceous glands, hair follicles, and epidermal differentiation. However, none of these genes exhibit inactivating mutations that are shared by cetaceans and hippos. Mean dates for the inactivation of skin genes in these two clades serve as proxies for phenotypic changes and suggest that hair reduction/loss, the loss of sebaceous glands, and changes to the keratinization program occurred similar to 16 Ma earlier in cetaceans (similar to 46.5 Ma) than in hippos (similar to 30.5 Ma). These results, together with histological differences in the integument and prior analyses of oxygen isotopes from stem hippopotamids ("anthracotheres''), support the hypothesis that aquatic skin adaptations evolved independently in hippos and cetaceans. | Springer, Mark S.; Guerrero-Juarez, Christian F.; Huelsmann, Matthias; Collin, Matthew A.; Danil, Kerri; McGowen, Michael R.; Oh, Ji Won; Ramos, Raul; Hiller, Michael; Plikus, Maksim V.; Gatesy, John | Univ Calif Riverside, Dept Evolut Ecol & Organismal Biol, Riverside, CA 92521 USA; Univ Calif Irvine, Dept Math, Irvine, CA 92697 USA; Univ Calif Irvine, NSF Simons Ctr Multiscale Cell Fate Res, Irvine, CA 92697 USA; Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA; Univ Calif Irvine, Sue & Bill Gross Stem Cell Res Ctr, Irvine, CA 92697 USA; Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany; Max Planck Inst Phys Komplexer Syst, D-01187 Dresden, Germany; Ctr Syst Biol Dresden, D-01307 Dresden, Germany; Univ Calif Riverside, Dept Bot & Plant Sci, Riverside, CA 92521 USA; Natl Marine Fisheries Serv, Southwest Fisheries Sci Ctr, NOAA, La Jolla, CA 92037 USA; Smithsonian Museum Nat Hist, Dept Vertebrate Zool, 10th & Constitut Ave NW, Washington, DC 20560 USA; Kyungpook Natl Univ, Sch Med, Dept Anat, Daegu, South Korea; Kyungpook Natl Univ Hosp, Biomed Res Inst, Daegu, South Korea; Kyungpook Natl Univ Hosp, Hair Transplantat Ctr, Daegu, South Korea; LOEWE Ctr Translat Biodivers Genom, D-60325 Frankfurt, Germany; Senckenberg Res Inst, D-60325 Frankfurt, Germany; Goethe Univ, Fac Biosci, D-60438 Frankfurt, Germany; Amer Museum Nat Hist, Div Vertebrate Zool, New York, NY 10024 USA; Amer Museum Nat Hist, Sackler Inst Comparat Genom, New York, NY 10024 USA; Eawag, Dept Environm Microbiol, CH-8600 Dubendorf, Switzerland; Swiss Fed Inst Technol, Dept Environm Syst Sci, CH-8092 Zurich, Switzerland | ; Guerrero-Juarez, Christian/MGB-3750-2025; Oh, Ji/AAZ-3153-2020 | 7103100228; 56004365500; 57211095809; 25649143000; 16309194700; 9844095800; 36093206200; 55758058000; 7006779784; 6506862971; 7004503476 | springer@ucr.edu;michael.hiller@senckenberg.de;plikus@uci.edu;jgatesy@amnh.org; | CURRENT BIOLOGY | CURR BIOL | 0960-9822 | 1879-0445 | 31 | 10 | SCIE | BIOCHEMISTRY & MOLECULAR BIOLOGY;BIOLOGY;CELL BIOLOGY | 2021 | 10.9 | 2.7 | 2.28 | 2025-07-30 | 35 | 32 | PROLINE-RICH PROTEIN; CETARTIODACTYLA MAMMALIA; AQUATIC HABITS; BOWHEAD WHALE; GENE LOSS; HAIR; INACTIVATION; EXPRESSION; HIPPOPOTAMIDAE; EVOLUTION | Cetacea; epidermis; gene loss; Hippopotamidae; histology; keratin; skin | Animals; Artiodactyla; Biological Evolution; Cetacea; Genome; Genomics; Phylogeny; Skin; Water; water; anatomy and histology; animal; Artiodactyla; Cetacea; evolution; genetics; genome; genomics; phylogeny; skin | English | 2021 | 2021-05-24 | 10.1016/j.cub.2021.02.057 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Longitudinal Changes in Fecal Calprotectin Levels Among Pregnant Women With and Without Inflammatory Bowel Disease and Their Babies | BACKGROUND & AIMS: The effect of pregnancy on inflammatory bowel disease (IBD) remains poorly understood. We aimed to monitor intestinal inflammation using fecal calprotectin (FC) in pregnant women and their babies during early life. METHODS: Pregnant women with or without IBD and their infants were prospectively enrolled. FC levels were measured at each trimester of pregnancy and in babies throughout the first 3 years of life. Repeated-measures analysis was applied to investigate changes in FC levels while adjusting for confounders. The FC levels were correlated with the bacterial abundance in both mothers and babies. RESULTS: Six hundred and fourteen fecal samples from 358 mothers (98 with IBD) and 1005 fecal samples from 289 infants (76 born to IBD mothers) were analyzed. Pregnant Patients with IBD maintained higher FC levels through pregnancy compared with controls (P = 7.5 x 10(-54)). FC gradually increased in controls and declined in Patients with IBD throughout pregnancy (P for interaction = 5.8 x 10(-7)). Babies born to mothers with IBD presented with significantly higher FC levels than those born to controls up to 3 years of age, after adjusting for sex, delivery mode, feeding behavior, and antibiotics exposure (2 weeks to 3 months of age, P = .015; 12-36 months of age, P = .00003). Subdoligranulum, Roseburia, Fusicatenibacter, and Alistipes negatively correlated, and Streptococcus, Prevotella, Escherichia-Shigella, and Bifidobacterium positively correlated with maternal FC levels at T3. Faecalibacterium, Bifidobacterium, and Alistipes showed negative correlations, and Streptococcus were positively correlated with FC levels within 3 months of birth. CONCLUSIONS: Pregnancy is associated with decreased inflammatory activity in mothers with IBD. Higher FC levels in babies born to mothers with IBD suggest subclinical inflammation in early life, the long-term consequences of which are uncertain. | Kim, Eun Soo; Tarassishin, Leonid; Eisele, Caroline; Barre, Amelie; Nair, Nilendra; Rendon, Alexa; Hawkins, Kelly; Debebe, Anketse; White, Sierra; Thjomoe, Anne; Mork, Einar; Bento-Miranda, Mario; Panchal, Hinaben; Agrawal, Manasi; Patel, Anish; Chen, Ching-Lynn; Kornbluth, Asher; George, James; Legnani, Peter; Maser, Elana; Loudon, Holly; Mella, Maria-Teresa; Stone, Joanne; Dubinsky, Marla; Sabino, Joao; Torres, Joana; Colombel, Jean-Frederic; Peter, Inga; Hu, Jianzhong | Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, 1425 Madison Ave, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Med, Henry D Janowitz Div Gastroenterol, New York, NY 10029 USA; Kyungpook Natl Univ, Sch Med, Dept Internal Med, Div Gastroenterol, Daegu, South Korea; Univ Paris, Cochin Hosp, Div Gastroenterol, Paris, France; Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA; CALPRO AS, Lysaker, Norway; Hosp & Univ Ctr Coimbra, Div Gastroenterol, Coimbra, Portugal; Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA; Brooke Army Med Ctr, Div Gastroenterol, San Antonio, TX USA; Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Obstet Gynecol & Reprod Sci, Div Maternal Fetal Med, New York, NY 10029 USA; Icahn Sch Med Mt Sinai, Dept Pediat Gastroenterol & Nutr, New York, NY 10029 USA; Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium; Hosp Beatriz Angelo, Surg Dept, Div Gastroenterol, Loures, Portugal | Hu, Jianzhong/ABE-4311-2020; Sabino, João/L-1093-2019; Patel, Anish/AAV-9400-2020; Kim, Sang/J-5398-2012 | 57203086704; 56307792200; 57208545105; 56355066500; 36677638400; 57216755490; 57216747150; 57196281145; 57205469385; 57222272196; 57222270253; 56460327000; 57202814841; 57213877152; 57214761981; 57208551494; 6701831348; 57199819112; 7004102385; 57188999764; 23061006800; 56348098300; 57210784005; 7003310173; 55849235000; 42762256300; 7102945104; 35737624800; 55499382500 | jianzhong.hu@mssm.edu; | GASTROENTEROLOGY | GASTROENTEROLOGY | 0016-5085 | 1528-0012 | 160 | 4 | SCIE | GASTROENTEROLOGY & HEPATOLOGY | 2021 | 33.883 | 2.7 | 3.83 | 2025-07-30 | 55 | 64 | Pregnancy; Inflammatory Bowel Disease; Fecal Calprotectin; Microbiome | INTESTINAL INFLAMMATION; ULCERATIVE-COLITIS; MICROBIOME; BIFIDOBACTERIUM; OUTCOMES; INDEXES; MARKER; HEALTH; IMPACT; TERM | Fecal Calprotectin; Inflammatory Bowel Disease; Microbiome; Pregnancy | Adult; Anti-Bacterial Agents; Bacteria; Case-Control Studies; Child, Preschool; Colitis, Ulcerative; Colonoscopy; Crohn Disease; Feces; Female; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Intestinal Mucosa; Leukocyte L1 Antigen Complex; Longitudinal Studies; Male; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Prospective Studies; Severity of Illness Index; adalimumab; antibiotic agent; calgranulin; immunomodulating agent; infliximab; mercaptopurine; mesalazine; probiotic agent; steroid; tumor necrosis factor inhibitor; vedolizumab; antiinfective agent; calgranulin; adult; Alistipes; Article; baby; Bifidobacterium; cesarean section; child; controlled study; disease activity; Escherichia; Faecalibacterium; feces level; female; first trimester pregnancy; Fusicatenibacter; human; infant; inflammatory bowel disease; longitudinal study; major clinical study; male; mother; newborn; pregnant woman; preschool child; Prevotella; priority journal; progeny; prospective study; Roseburia; second trimester pregnancy; Shigella; Streptococcus; Subdoligranulum; third trimester pregnancy; vaginal delivery; bacterium; case control study; chemistry; colonoscopy; Crohn disease; drug effect; feces; immunology; intestine flora; intestine mucosa; isolation and purification; microbiology; pregnancy; pregnancy complication; prenatal exposure; severity of illness index; ulcerative colitis | English | 2021 | 2021-03 | 10.1053/j.gastro.2020.11.050 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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