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| WoS | SCOPUS | Document Type | Document Title | Abstract | Authors | Affiliation | ResearcherID (WoS) | AuthorsID (SCOPUS) | Author Email(s) | Journal Name | JCR Abbreviation | ISSN | eISSN | Volume | Issue | WoS Edition | WoS Category | JCR Year | IF | JCR (%) | FWCI | FWCI Update Date | WoS Citation | SCOPUS Citation | Keywords (WoS) | KeywordsPlus (WoS) | Keywords (SCOPUS) | KeywordsPlus (SCOPUS) | Language | Publication Stage | Publication Year | Publication Date | DOI | JCR Link | DOI Link | WOS Link | SCOPUS Link |
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| ○ | ○ | Article | A surface plasmon resonance biosensor in conjunction with a DNA aptamer-antibody bioreceptor pair for heterogeneous nuclear ribonucleoprotein A1 concentrations in colorectal cancer plasma solutions | A new DNA aptamer and antibody pair was incorporated into surface plasmon resonance (SPR) sensing platform to detect heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) in plasma at clinically relevant native concentrations for the diagnosis of colorectal cancer (CRC). SPR detection of hnRNP A1 was realized via formation of the surface sandwich complex of aptamer/hnRNP A1/anti-hnRNP A; the specific adsorption of hnRNP A1 onto a gold chip surface modified with a DNA aptamer followed by the adsorption of anti-hnRNP A1. Changes in the refractive unit (RU) with respect to the hnRNP A1 concentration in buffer solutions were monitored at a fixed anti-hnRNP A1 concentration of 90 nM, resulting in a dynamic range of 0.1-10 nM of hnRNP A1. The surface sandwich SPR biosensor was further applied to the direct analysis of undiluted human normal and pooled CRC patient plasma solutions. Our plasma analysis results were compared to those obtained with a commercial enzyme-linked immunosorbent assay kit. | Lee, Sang Hyuk; Park, Yae Eun; Lee, Ji Eun; Lee, Hye Jin | Kyungpook Natl Univ, Dept Chem, 80 Daehakro, Daegu City 41566, South Korea; Kyungpook Natl Univ, Green Nano Mat Res Ctr, 80 Daehakro, Daegu City 41566, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Ctr Theragnosis, 5 Hwarang Ro 14 Gil, Seoul 02792, South Korea | LEE, HYEJIN/W-1345-2018 | 55188583800; 57196453951; 55992294200; 56569175200 | jelee9137@kist.re.kr;hyejinlee@knu.ac.kr; | BIOSENSORS & BIOELECTRONICS | BIOSENS BIOELECTRON | 0956-5663 | 1873-4235 | 154 | SCIE | BIOPHYSICS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 10.618 | 2.9 | 1.25 | 2025-06-25 | 33 | 32 | Surface sandwich assay; HnRNP A1; DNA aptamer/antibody bioreceptor pair; Surface plasmon resonance; Colorectal cancer; Human plasma | AVIAN INFLUENZA-VIRUS; DIAGNOSTIC-ACCURACY; PROTEIN BIOMARKERS; CARDIAC BIOMARKER; HNRNP A1; IDENTIFICATION; IMMUNOASSAY; MRI | Colorectal cancer; DNA aptamer/antibody bioreceptor pair; HnRNP A1; Human plasma; Surface plasmon resonance; Surface sandwich assay | Aptamers, Nucleotide; Biosensing Techniques; Colorectal Neoplasms; Gold; Heterogeneous Nuclear Ribonucleoprotein A1; Humans; Surface Plasmon Resonance; Antibodies; Biosensors; Diseases; DNA; Plasmons; aptamer; DNA; heterogeneous nuclear ribonucleoprotein A1; heterogeneous nuclear ribonucleoprotein A1 antibody; ribonucleoprotein antibody; unclassified drug; aptamer; gold; heterogeneous nuclear ribonucleoprotein A1; hnRNPA1 protein, human; Bioreceptors; Colorectal cancer; HnRNP A1; Human plasmas; Sandwich assays; antibody detection; Article; blood analysis; blood sampling; cancer diagnosis; clinical article; colorectal cancer; controlled study; enzyme linked immunosorbent assay; human; mathematical model; protein blood level; surface plasmon resonance; blood; chemistry; colorectal tumor; genetic procedures; isolation and purification; surface plasmon resonance; Surface plasmon resonance | English | 2020 | 2020-04-15 | 10.1016/j.bios.2020.112065 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Simultaneous on-chip isolation and characterization of circulating tumor cell sub-populations | The diagnosis of tumor metastasis using circulating tumor cells (CTCs) has been considered an important developmental target for several decades but remains a formidable challenge because of the rarity and heterogeneity of CTCs. Additional downstream analysis is required after isolating CTCs on-chip for subtype verification. To solve those problems, we have developed microfluidic based integrated system which uses magnetic field gradient and immune-fluorescence differences to on-chip isolation and discrimination of CTCs simultaneously. The system presented in the present study can isolate CTCs with an efficiency of >99% by utilizing magnetic nanoparticles conjugated to CTC membranes. Furthermore, the statuses of three biomarkers can be determined on-chip simultaneously. The devised microfluidic system can differentiate eight different subtypes of heterogenic CTCs by on-chip isolation and based on the statuses of three biomarkers (HER2, ER, and PR) which are critical variables to five-year overall survivals for breast cancer patients. | Lee, Jaehun; Kwak, Bongseop | Korea Inst Machinery & Mat, Daegu Res Ctr Med Devices & Rehab Engn, Dept Med Device, 330 Techno Sunhwan Ro, Dalsung Gun 42994, Daegu, South Korea; Kyungpook Natl Univ, Coll IT Engn, Sch Elect Engn, 80 Daehak Ro, Daegu 41566, South Korea; Dongguk Univ, Coll Med, 32 Dongguk Ro, Goyangsi 10326, Gyeonggi Do, South Korea | 59324626500; 25960174800 | bskwak82@gmail.com; | BIOSENSORS & BIOELECTRONICS | BIOSENS BIOELECTRON | 0956-5663 | 1873-4235 | 168 | SCIE | BIOPHYSICS;BIOTECHNOLOGY & APPLIED MICROBIOLOGY;CHEMISTRY, ANALYTICAL;ELECTROCHEMISTRY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 10.618 | 2.9 | 1.18 | 2025-06-25 | 24 | 25 | Circulating tumor cells (CTCs); CTC isolation; Selective isolation; Discrimination of heterogenic CTCs | CANCER-PATIENTS; CAPTURE | Circulating tumor cells (CTCs); CTC isolation; Discrimination of heterogenic CTCs; Selective isolation | Biomarkers, Tumor; Biosensing Techniques; Cell Line, Tumor; Cell Separation; Humans; Microfluidics; Neoplastic Cells, Circulating; Biomarkers; Magnetic nanoparticles; Microfluidics; Tumors; epidermal growth factor receptor 2; estrogen receptor; magnetic nanoparticle; progesterone receptor; tumor marker; Circulating tumor cells; Critical variables; Integrated systems; Magnetic field gradient; Micro fluidic system; Microfluidic-based; On-chip isolation; Overall survival; Article; BT-474 cell line; cancer patient; cell heterogeneity; cell isolation; circulating tumor cell; controlled study; female; human; human cell; immunofluorescence test; magnetic field; MCF-7 cell line; MDA-MB-231 cell line; microfluidic analysis; overall survival; protein analysis; SK-BR-3 cell line; survival time; cell separation; genetic procedures; microfluidics; tumor cell line; tumor embolism; Diagnosis | English | 2020 | 2020-11-15 | 10.1016/j.bios.2020.112564 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Electrophoretic deposition of a supercapacitor electrode of activated carbon onto an indium-tin-oxide substrate using ethyl cellulose as a binder | A transparent energy storage device is an essential component for transparent electronics. The increasing demand for high-power devices stimulates the development of transparent supercapacitors with high power density. A transparent electrode for such supercapacitors can be assembled via the electrophoretic deposition of an active material powder with a binder onto a transparent substrate. The properties of the binder critically influence the electrochemical behavior and performance of the resulting electrode. Ethyl cellulose (EC) is known as an eco-friendly, transparent, flexible, and inexpensive material. Here, we fabricated an electrode film with EC binder via electrophoretic deposition on an indium tin oxide (ITO) substrate instead of using the conventional polytetrafluoroethylene (PTFE) binder. The assembled electrodes with EC and PTFE were compared to investigate the feasibility of EC as a binder from different perspectives, including homogeneity, wettability, electrochemical behavior, and mechanical stability. The EC enabled the formation of a homogeneous film composed of smaller particles and with a higher specific capacitance compared with films prepared with PTFE. The annealing improved the adhesion strength of the EC because of its glass transition; however, its hydrophobic nature limited utilization of the active material for charge storage. Subsequent electrochemical activation improved the wettability of the electrode, resulting in an increased capacitance of 60 F g(-1). Furthermore, even with the lower wettability of EC compared with that of PTFE, better rate performance was possible with the EC electrode. The increased mechanical stability after the annealing process ensured an excellent cycle life of 95 % capacitance retention for 15,000 cycles. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. | Kim, Taeuk; Yi, Seong-Hoon; Chun, Sang-Eun | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea | Yi, Seonghoon/HGC-6912-2022 | 57217345733; 14008383000; 36801080300 | sangeun@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 1941-1162 | 58 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2020 | 8.067 | 3.1 | 1.7 | 2025-06-25 | 31 | 32 | Electrophoretic deposition; Transparent electrode; Activated carbon; Ethyl cellulose; Indium tin oxide | ELECTROCHEMICAL PERFORMANCE; NATURAL CELLULOSE; ENERGY-STORAGE; ETHYLCELLULOSE; FILMS; TRANSITION; CAPACITORS; NANOTUBES; BATTERIES; CATHODES | Activated carbon; Electrophoretic deposition; Ethyl cellulose; Indium tin oxide; Transparent electrode | Activated Carbon; Capacitance; Cellulose; Deposition; Electrophoresis; Indium Compounds; Activated carbon; Capacitance; Cellulose; Deposition; Electrophoresis; Glass transition; Indium compounds; ITO glass; Mechanical stability; Substrates; Supercapacitor; Tin oxides; Transparent electrodes; Wetting; Capacitance retention; Electrochemical activation; Electrochemical behaviors; Electrophoretic depositions; Indium tin oxide substrates; Polytetrafluoroethylene (PTFE); Supercapacitor electrodes; Transparent electronics; Electrochemical electrodes | English | 2020 | 2020-12-01 | 10.1016/j.jmst.2020.03.072 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Induction of SIRT1 by melatonin improves alcohol-mediated oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway | Alcoholic liver disease is the most prevalent chronic liver disease. Melatonin is known to control many vital processes. Here, we explored a novel molecular mechanism by which melatonin-induced SIRT1 signaling protects against alcohol-mediated oxidative stress and liver injury. Gene expression profiles and metabolic changes were measured in liver specimens of mice and human subjects. Expression levels of Cb1r, Crbn, Btg2, Yy1, pro-inflammatory cytokines, and Cyp2e1 were significantly enhanced in chronic alcohol-challenged mice and human subjects. Levels of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), hepatic CYP2E1 protein, and reactive oxygen species (ROS) were elevated in alcohol-fed WT mice but not in Cb1r antagonist-treated, Crbn null, or Yy1-silenced mice. Importantly, alcohol-induced Yy1 and Cyp2e1 expression, ROS amount, and liver injury were markedly diminished by melatonin treatment and the transduction of Sirt1 in mice, whereas this phenomenon was prominently ablated by silencing of Sirt1. Notably, SIRT1 physically interacted with YY1 and attenuated YY1 occupancy on the Cyp2e1 gene promoter. Melatonin-SIRT1 signaling ameliorates alcohol-induced oxidative liver injury by disrupting the CRBN-YY1-CYP2E1 signaling pathway. The manipulation of CRBN-YY1-CYP2E1 signaling network by the melatonin-SIRT1 pathway highlights a novel entry point for treating alcoholic liver disease. | Lee, Sung-Eun; Koh, Hong; Joo, Dong Jin; Nedumaran, Balachandar; Jeon, Hwang-Ju; Park, Chul-Seung; Harris, Robert A.; Kim, Yong Deuk | Kyungpook Natl Univ, Sch Appl Biosci, Daegu 41566, South Korea; Yonsei Univ, Div Gastroenterol Hepatol & Nutr, Severance Pediat Liver Dis Res Grp, Severance Childrens Hosp,Dept Pediat,Coll Med, Seoul, South Korea; Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea; Univ Colorado, Sch Med, Dept Surg, Anschutz Med Campus, Aurora, CO USA; Gwangju Inst Sci & Technol, Sch Life Sci, Gwangju, South Korea; Gwangju Inst Sci & Technol, Cell Logist Res Ctr, Gwangju, South Korea; Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA | ; Jeon, Hwangju/JDW-9035-2023; Nedumaran, Balachandar/V-9958-2019 | 55890041600; 35789948700; 57216087775; 23976497500; 56328792200; 57198831126; 35430442700; 55549957700 | ydkim94@knu.ac.kr; | JOURNAL OF PINEAL RESEARCH | J PINEAL RES | 0742-3098 | 1600-079X | 68 | 3 | SCIE | ENDOCRINOLOGY & METABOLISM;NEUROSCIENCES;PHYSIOLOGY | 2020 | 13.007 | 3.1 | 2.26 | 2025-06-25 | 38 | 43 | alcoholic liver disease; melatonin; metabolism; oxidative liver injury; reactive oxygen species; Sirt1 | YIN YANG 1; ENDOCANNABINOID SYSTEM; DISEASE PATHOGENESIS; CEREBLON; CYP2E1; RECEPTOR; STRESS | alcoholic liver disease; cytochrome P450 2E1; melatonin; metabolism; oxidative liver injury; reactive oxygen species; Sirt1 | Adaptor Proteins, Signal Transducing; Animals; Cytochrome P-450 CYP2E1; Humans; Liver Diseases, Alcoholic; Melatonin; Mice; Oxidative Stress; Signal Transduction; Sirtuin 1; Ubiquitin-Protein Ligases; YY1 Transcription Factor; alanine aminotransferase; alcohol; aspartate aminotransferase; bile acid; btg2 protein; cannabinoid 1 receptor; cereblon; cholesterol; collagen type 1; collagen type 1a1; cytochrome P450 2E1; glutathione peroxidase; hydrogen peroxide; interleukin 6; liver protein; malonaldehyde; melatonin; messenger RNA; reactive oxygen metabolite; regulator protein; rimonabant; sirtuin 1; superoxide dismutase; thiobarbituric acid reactive substance; transcription factor YY1; triacylglycerol; tumor necrosis factor; unclassified drug; CRBN protein, human; Crbn protein, mouse; cytochrome P450 2E1; melatonin; signal transducing adaptor protein; sirtuin 1; transcription factor YY1; ubiquitin protein ligase; alanine aminotransferase blood level; alcohol consumption; alcohol liver disease; animal experiment; animal model; animal tissue; Article; aspartate aminotransferase blood level; bile acid blood level; cholesterol blood level; controlled study; down regulation; gene expression profiling; gene silencing; genetic transduction; human; human tissue; Lieber-DeCarli ethanol diet; lipid peroxidation; lipid storage; liver injury; liver protection; liver tissue; liver weight; male; mouse; mRNA expression level; nonhuman; oxidative stress; promoter region; protein expression level; protein protein interaction; signal transduction; triacylglycerol blood level; upregulation; alcohol liver disease; animal; metabolism; oxidative stress; physiology; signal transduction | English | 2020 | 2020-04 | 10.1111/jpi.12638 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | ○ | Article | Influence of Bi addition on dynamic recrystallization and precipitation behaviors during hot extrusion of pure Mg | Low material cost and high extrudability for ensuring price competitiveness with Al alloys, as well as excellent mechanical properties, are essential for expanding the application range of Mg extrudates. Bi is a promising alloying element for developing extruded Mg alloys that satisfy such requirements. Bi is inexpensive, exhibits a high solubility limit, and forms a thermally stable Mg3Bi2 phase, which improves the commercial viability and enables the high-speed extrusion of Mg-Bi alloys. In this study, the effects of Bi addition on the dynamic recrystallization (DRX) and dynamic precipitation behaviors during hot extrusion of a pure Mg and the resultant microstructure and mechanical properties of the extruded materials were investigated. The addition of 6 wt% and 9 wt% Bi to a pure Mg yielded numerous fine Mg3Bi2 precipitates during the early stage of hot extrusion. Consequently, the area fraction of dynamic recrystallized (DRXed) grains decreased because of DRX-behavior suppression by the Zener pinning effect. However, the DRXed grain size was substantially reduced through the grain-boundary pinning effect. The size and number of undissolved Mg3Bi2 particles in the homogenized billets increased when the Bi content was increased, which resulted in increased DRX fractions owing to the enhanced levels of particle stimulated nucleation. Bi addition yielded considerable strength improvement of the extruded pure Mg. However, the extruded Mg-Bi binary materials were less ductile than the extruded pure Mg material. This lower ductility resulted from the cracking at twins formed in the coarse unDRXed grains of the Mg-6Bi material and the cracking at large undissolved Mg3Bi2 particles in the Mg-9Bi material. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. | Go, Jongbin; Lee, Jong Un; Yu, Hui; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 41566, South Korea; Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China | Park, Sung-Hyuk/AAE-6726-2022; yu, hui/H-8481-2012; Yu, Hui/H-8481-2012 | 57204606110; 57195056728; 7405855938; 54786002500 | sh.park@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 44 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2020 | 8.067 | 3.1 | 3.63 | 2025-06-25 | 81 | 78 | Magnesium; Bi addition; Extrusion; Recrystallization; Precipitation | RARE-EARTH TEXTURE; MECHANICAL-PROPERTIES; NUCLEATION SITES; ZN ALLOYS; MICROSTRUCTURE; SPEED; CA; DUCTILITY | Bi addition; Extrusion; Magnesium; Precipitation; Recrystallization | Alloying elements; Aluminum alloys; Binary alloys; Cracks; Crystallization; Dynamic recrystallization; Dynamics; Extrusion; Grain boundaries; Magnesium; Magnesium alloys; Mechanical properties; Precipitation (chemical); Commercial viability; Dynamic precipitation; Dynamic recrystallization (DRX); Microstructure and mechanical properties; Particle stimulated nucleation; Precipitation behavior; Price competitiveness; Strength improvements; Bismuth alloys | English | 2020 | 2020-05-01 | 10.1016/j.jmst.2019.10.036 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | Meeting Abstract | POSTOPERATIVE RADIOTHERAPY FOR WHO GRADE II-III INTRACRANIAL EPENDYMOMA IN ADULTS: AN INTERGROUP COLLABORATIVE STUDY (KROG 18-06/KNOG 18-01) | Wee, Chan Woo; Kim, Il Han; Park, Chul-Kee; Lim, Do Hoon; Nam, Do-Hyun; Yoon, Hong In; Suh, Chang-Ok; Chang, Jong Hee; Chung, Woong-Ki; Jung, Tae-Young; Park, Shin-Hyung; Kim, Chae-Yong; Kim, Young Zoon; Gwak, Ho Shin; Cho, Kwan Ho; Kim, Jin Hee; Im, Jung Ho; Kim, Woo Chul; Kim, Sung-Hwan; Kim, In Ah | SMU SNU Boramae Med Ctr, Seoul, South Korea; Seoul Natl Univ Hosp, Seoul, South Korea; Samsung Med Ctr, Seoul, South Korea; Yonsei Canc Ctr, Seoul, South Korea; Yonsei Univ Hlth Syst, Seoul, South Korea; Chonnam Natl Univ, Hwasun Hosp, Hwasun, South Korea; Kyungpook Natl Univ, Sch Med, Daegu, South Korea; Seoul Natl Univ, Bundang Hosp, Seongnam, South Korea; Sungkyunkwan Univ, Samsung Changwon Hosp, Chang Won, South Korea; Natl Canc Ctr, Goyang, South Korea; Keimyung Univ, Dongsan Med Ctr, Daegu, South Korea; CHA Bundang Med Ctr, Seongnam, South Korea; Inha Univ Hosp, Incheon, South Korea; Catholic Univ Korea, St Vincents Hosp, Sch Med, Suwon, South Korea | Cho, Hwa Jin/AFA-1420-2022; Park, Shinhyung/LNQ-6428-2024; Kim, In/J-5426-2012; Kim, Yong/L-8289-2019; Kim, Min/ACN-6827-2022; Kim, Tae-You/J-2750-2012; Park, Chul-Kee/J-5499-2012; Kim, Sung Hwan/GQQ-1731-2022; , Do Hyun Nam/C-9656-2011 | NEURO-ONCOLOGY | NEURO-ONCOLOGY | 1522-8517 | 1523-5866 | 22 | SCIE | CLINICAL NEUROLOGY;ONCOLOGY | 2020 | 12.3 | 3.1 | 0 | English | 2020 | 2020-11 | 바로가기 | 바로가기 | ||||||||||||||||
| ○ | ○ | Article | Variation in dynamic deformation behavior and resultant yield asymmetry of AZ80 alloy with extrusion temperature | In this work, variation in the dynamic recrystallization (DRX) and dynamic precipitation behavior of AZ80 alloy during extrusion due to changes in extrusion temperature was investigated, and the resultant microstructure and yield asymmetry were analyzed. As the extrusion temperature increases from 250 degrees C to 350 degrees C, the primary DRX mechanism changes from twin-induced DRX to discontinuous DRX, resulting in an increase in the DRX area fraction and unDRXed grain size. In addition, as the extrusion temperature rises, Mg17Al12 precipitation during extrusion decreases sharply throughout the extruded material. The reduction in the compressive yield strength (CYS) with increasing extrusion temperature is more pronounced than it is for the tensile yield strength (TYS), which ultimately increases the yield asymmetry of the extruded material. The higher extrusion temperature has less of an influence on the TYS due to the promotion of certain hardening effects. On the other hand, the greater reduction in the CYS is attributed to the increased fraction and size of regions in which {10 (1) over bar2} twins predominantly form and the lower amount of precipitates, which effectively facilitates {10 (1) over bar2} twinning. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. | Kim, Sang-Hoon; Lee, Sang Won; Moon, Byoung Gi; Kim, Ha Sik; Park, Sung Hyuk | Kyungpook Natl Univ, Sch Mat Sci & Engn, Daegu 702701, South Korea; Korea Inst Mat Sci, Implementat Res Div, Chang Won 51508, South Korea | Park, Sung-Hyuk/AAE-6726-2022; Kim, Sang-Hoon/AAD-8797-2021; Lee, Sangwon/AAJ-7850-2020 | 57206878833; 57201375104; 7101878674; 53979899800; 54786002500 | sh.park@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 46 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2020 | 8.067 | 3.1 | 2.93 | 2025-06-25 | 58 | 59 | Magnesium alloys; Extrusion; Recrystallization; Precipitation; Yield asymmetry | MECHANICAL-PROPERTIES; MAGNESIUM ALLOY; ROOM-TEMPERATURE; MG-3AL-1ZN ALLOY; AGING PRIOR; GRAIN-SIZE; MICROSTRUCTURE; MG; RECRYSTALLIZATION; TEXTURE | Extrusion; Magnesium alloys; Precipitation; Recrystallization; Yield asymmetry | Aluminum alloys; Binary alloys; Crystallization; Dynamic recrystallization; Extrusion; Magnesium alloys; Precipitation (chemical); Yield stress; Dynamic deformation behavior; Dynamic precipitation; Dynamic recrystallization (DRX); Extruded materials; Extrusion temperatures; Hardening effects; Tensile yield strength; Yield asymmetry; Tensile strength | English | 2020 | 2020-06-01 | 10.1016/j.jmst.2019.11.033 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | Visible-light-activated N-doped CQDs/g-C3N4/Bi2WO6 nanocomposites with different component arrangements for the promoted degradation of hazardous vapors | To investigate whether the arrangement of componentsin multi-composite photocatalysts may affect their photocatalytic properties, due to different charge-transfer routes, two ternary-nanocomposite photocatalysts with different component arrangements, comprising N-doped carbon quantum dots (NCQDs), g-C3N4 (CN), and Bi2WO6 (BWO) (hereafter referred to as NCQDs/CNIBWO), were developed, and the photocatalytic degradation of model hazardous vapors under visible-light illumination was investigated. Type I NCQDs/CN/BWO, which was developed by the combination of NCQDs/BWO and CN, exhibited photocatalytic ability superior to that of type II NCQDs/CN/BWO, which was developed by the combination of CN/BWO and NCQDs; the superior photocatalytic ability corresponded to the dual properties of NCQDs: charge mediation and upconversion photoluminescence. Moreover, the photocatalytic ability of NCQDs/CN/BWO was greater than those of the reference catalysts; in addition, this photocatalyst exhibited outstanding photochemical stability. Additionally, the effects of CN/(BWO + CN) weight ratio of the CN/BWO dual nanocomposites and the NCQDs/(BWO + CN + NCQDs) weight percentage of NCQDs/CN/BWO ternary nanocomposites on the pollutant removal efficiency were investigated. The plausible mechanisms over the two NCQDs/CN/BWO photocatalysts for the degradation of hazardous vapors were discussed. The component arrangement approach proposed herein afforded a technique toward the perceptive development of novel multi-component heterostructures for the photocatalytic degradation of hazardous vapors. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. | Kim, Mi Gyeong; Jo, Wan-Kuen | Kyungpook Natl Univ, Dept Environm Engn, 80 Univ Rd, Daegu 702701, South Korea | Jo, Wan/AAO-5329-2020; Kim, Mi/AAO-5092-2020 | 57192680180; 7103322277 | wkjo@knu.ac.kr; | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY | J MATER SCI TECHNOL | 1005-0302 | 40 | SCIE | MATERIALS SCIENCE, MULTIDISCIPLINARY;METALLURGY & METALLURGICAL ENGINEERING | 2020 | 8.067 | 3.1 | 2.55 | 2025-06-25 | 44 | 46 | Component arrangement; Charge-transfer route; NCQDs dual role; Charge mediator; Upconversion photoluminescence | GRAPHITIC CARBON NITRIDE; PHOTOCATALYTIC ACTIVITY; ULTRATHIN NANOSHEETS; QUANTUM DOTS; G-C3N4; CONSTRUCTION; COMPOSITE; MECHANISM; POLLUTION | Charge mediator; Charge-transfer route; Component arrangement; NCQDs dual role; Upconversion photoluminescence | Bismuth compounds; Charge transfer; Doping (additives); Hazards; Light; Microwave oscillators; Nanocomposites; Photoluminescence; Semiconductor quantum dots; Charge mediator; Component arrangement; Composite photocatalysts; Dual role; Photo catalytic degradation; Photocatalytic property; Pollutant removal efficiency; Up-conversion; Photocatalytic activity | English | 2020 | 2020-03-01 | 10.1016/j.jmst.2019.09.026 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||
| ○ | ○ | Article | CRISPR/Cas9-mediated editing of 1-aminocyclopropane-1-carboxylate oxidase1 enhances Petunia flower longevity | The genes that encode the ethylene biosynthesis enzyme 1-aminocyclopropane-1-carboxylate oxidase (ACO) are thought to be involved in flower senescence. Hence, we investigated whether the transcript levels of PhACO genes (PhACO1, PhACO3 and PhACO4) in Petunia cv. Mirage Rose are associated with ethylene production at different flowering stages. High transcript levels were detected in the late flowering stage and linked to high ethylene levels. PhACO1 was subsequently edited using the CRISPR/Cas9 system, and its role in ethylene production was investigated. PhACO1-edited T-0 mutant lines, regardless of mutant type (homozygous or monoallelic), exhibited significantly reduced ethylene production and enhanced flower longevity compared with wild-type. Flower longevity and the reduction in ethylene production were observed to be stronger in homozygous plants than in their monoallelic counterparts. Additionally, the transmission of the edited gene to the T-1 (lines 6 and 36) generation was also confirmed, with the results for flower longevity and ethylene production proving to be identical to those of the T-0 mutant lines. Overall, this study increases the understanding of the role of PhACO1 in petunia flower longevity and also points to the CRISPR/Cas9 system being a powerful tool in the improvement of floricultural quality. | Xu, Junping; Kang, Beum-Chang; Naing, Aung Htay; Bae, Su-Ji; Kim, Jin-Soo; Kim, Hyeran; Kim, Chang Kil | Kyungpook Natl Univ, Dept Hort Sci, Daegu, South Korea; Inst for Basic Sci Korea, Ctr Genome Engn, Daejeon, South Korea; Kangwon Natl Univ, Dept Biol Sci, Chunchon, South Korea | KIM, Jin-Soo/M-6918-2013; Kim, Hyeran/AAB-5165-2021; Naing, Aung Htay/AAF-4277-2019 | 56677024300; 57188734085; 37112768100; 57195463630; 55949820500; 57203911179; 7409880701 | ckkim@knu.ac.kr; | PLANT BIOTECHNOLOGY JOURNAL | PLANT BIOTECHNOL J | 1467-7644 | 1467-7652 | 18 | 1 | SCIE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY;PLANT SCIENCES | 2020 | 9.803 | 3.2 | 6.56 | 2025-06-25 | 94 | 107 | ethylene production; gene expression; genome editing; mutation; Petunia hybrida | SODIUM-NITROPRUSSIDE SNP; VASE LIFE; EXPRESSION; ETHYLENE; PLANTS; SENESCENCE; CRISPR-CAS9; MECHANISM; RICE | ethylene production; gene expression; genome editing; mutation; Petunia hybrida | Amino Acid Oxidoreductases; CRISPR-Cas Systems; Flowers; Gene Editing; Petunia; Plants, Genetically Modified; 1-aminocyclopropane-1-carboxylic acid oxidase; oxidoreductase; CRISPR Cas system; enzymology; flower; gene editing; genetics; growth, development and aging; Petunia; transgenic plant | English | 2020 | 2020-01 | 10.1111/pbi.13197 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |
| ○ | Review | Handcrafted and deep trackers: Recent visual object tracking approaches and trends | In recent years, visual object tracking has become a very active research area. An increasing number of tracking algorithms are being proposed each year. It is because tracking has wide applications in various real-world problems such as human-computer interaction, autonomous vehicles, robotics, surveillance, and security just to name a few. In the current study, we review latest trends and advances in the tracking area and evaluate the robustness of different trackers based on the feature extraction methods. The first part of this work includes a comprehensive survey of the recently proposed trackers. We broadly categorize trackers into Correlation Filter based Trackers (CFTs) and Non-CFTs. Each category is further classified into various types based on the architecture and the tracking mechanism. In the second part of this work, we experimentally evaluated 24 recent trackers for robustness and compared handcrafted and deep feature based trackers. We observe that trackers using deep features performed better, though in some cases a fusion of both increased performance significantly. To overcome the drawbacks of the existing benchmarks, a new benchmark Object Tracking and Temple Color (OTTC) has also been proposed and used in the evaluation of different algorithms. We analyze the performance of trackers over 11 different challenges in OTTC and 3 other benchmarks. Our study concludes that Discriminative Correlation Filter (DCF) based trackers perform better than the others. Our study also reveals that inclusion of different types of regularizations over DCF often results in boosted tracking performance. Finally, we sum up our study by pointing out some insights and indicating future trends in the visual object tracking field. © 2019 Association for Computing Machinery. | Fiaz, Mustansar; Mahmood, Arif; Javed, Sajid; Jung, Soon Ki | School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea; Department of Computer Science, Information Technology University, Ferozepur Road, Lahore, Pakistan; University of Warwick, Coventry, CV4 7AL, United Kingdom; School of Computer Science and Engineering, Kyungpook National University, Daegu, South Korea | 57208735843; 55636036300; 56040144300; 57226791905 | ACM Computing Surveys | ACM COMPUT SURV | 0360-0300 | 1557-7341 | 52 | 2 | SCIE | COMPUTER SCIENCE, THEORY & METHODS | 2020 | 10.282 | 3.2 | 2.02 | 2025-06-25 | 116 | Object tracking; Robustness of tracking algorithms; Surveillance; Tracking evaluation | Benchmarking; Human robot interaction; Tracking (position); Correlation filters; Filter-based; Object Tracking; Performance; Robustness of tracking algorithm; Surveillance; Tracking algorithm; Tracking approaches; Tracking evaluation; Visual object tracking; Human computer interaction | English | Final | 2020 | 10.1145/3309665 | 바로가기 | 바로가기 | 바로가기 | ||||||||
| ○ | ○ | Article | Influences of combined enzyme-ultrasonic extraction on the physicochemical characteristics and properties of okra polysaccharides | This study obtained two novel polysaccharides from okra by enzyme-assisted and combined enzyme-ultrasonic methods while comparing with previously established hot-water, ultrasonic methods, for their food application potentials. Structural characteristics and physicochemical properties were evaluated and their relationships with functional properties and biological activities including viscosity, emulsifying abilities, antioxidant and antimicrobial activities were observed. All okra polysaccharides (OKPs) showed similar structural features as revealed by H-1 NMR, in accordance with FT-IR spectroscopy. The result of monosaccharide composition confirmed isolated OKPs as acidic heteropolysaccharides consisting of galactose, glucose, rhamnose, arabinose, galacturonic and glucuronic acid, in the varying molar percentages of 33.8-38.6%, 12.4-17.9%, 13.7-17.5%, 3.0-9.9%, 19.0-21.2%, and 6.7-8.3%, respectively. All OKPs were broadly polydispersed with molecular weights (M-w) ranging between 129 and 193 x 10(3) g mol(-1), polysaccharide content ranging from 43.95 to 70.75%, a high degree of acetylation (20.81-37.88%) and low methyl-esterification (26.9-38.95%). Combined enzyme-ultrasonic extracted polysaccharide (CEUP) exhibited superior properties such as solubility, emulsifying capacity, high antioxidant activity and showed more potency in Escherichia coli and Listeria monocytogenes inhibition, extending its versatility in food applications. Principal component analysis (PCA) revealed CEUP to possess unique characteristics different from other samples, substantiating the significance of combined extraction technology over single techniques. Overall, the present study suggests OKP extracted by enzyme-ultrasonic technology as a potential new source of food hydrocolloid with novel functional and biological properties adoptable in the food industry as coating material and food ingredients. | Olawuyi, Ibukunoluwa Fola; Kim, Soo Rin; Hahn, Dongyup; Lee, Won Young | Kyungpook Natl Univ, Sch Food Sci & Biotechnol, Daegu 41566, South Korea | Olawuyi, Ibukunoluwa/H-1232-2018; Kim, Soo Rin/X-2192-2019; Lee, Wonyoung/AAL-2780-2021 | 57204471854; 36659584200; 36554163400; 57195940408 | wonyoung@knu.ac.kr; | FOOD HYDROCOLLOIDS | FOOD HYDROCOLLOID | 0268-005X | 1873-7137 | 100 | SCIE | CHEMISTRY, APPLIED;FOOD SCIENCE & TECHNOLOGY | 2020 | 9.147 | 3.2 | 5.27 | 2025-06-25 | 120 | 124 | Okra; Polysaccharide; Extraction method; Functional properties; Biological properties | ASSISTED EXTRACTION; PECTIC POLYSACCHARIDES; ANTIOXIDANT ACTIVITIES; RHEOLOGICAL PROPERTIES; OPTIMIZATION; SURFACE; GUM | Biological properties; Extraction method; Functional properties; Okra; Polysaccharide | Acetylation; Antioxidants; Emulsification; Enzymes; Escherichia coli; Glucose; Physicochemical properties; Polysaccharides; Principal component analysis; Antioxidant activities; Biological properties; Extraction method; Food applications; Functional properties; Okra; Physicochemical characteristics; Physicochemical property; Ultrasonic extraction; Ultrasonic methods; Extraction | English | 2020 | 2020-03 | 10.1016/j.foodhyd.2019.105396 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Hexagonal Stacking Faults Act as Hole-Blocking Layers in Lead Halide Perovskites | The transformation between black (corner sharing) and yellow (face sharing) polytypes of lead halide perovskites is a major performance bottleneck. We investigate phase intermixing through the simulation of stacking faults (nano-domains) that reveal a small thermodynamic cost but large electronic consequences in CsPbI3. | Park, Ji-Sang; Li, Zhenzhu; Wilson, Jacob N.; Yin, Wan-Jian; Walsh, Aron | Imperial Coll London, Dept Mat, London SW7 2AZ, England; Yonsei Univ, Dept Mat Sci & Engn, Seoul 03722, South Korea; Kyungpook Natl Univ, Dept Phys, Daegu 41566, South Korea; Soochow Univ, Soochow Inst Energy & Mat Innovat SIEMIS, Coll Energy, Suzhou 215006, Peoples R China | ; Yin, Wan-Jian/AAG-1612-2020; Li, Zhenzhu/AAK-7744-2021; Yin, Wan-Jian/F-6738-2013; Park, Ji-Sang/F-9944-2010; Walsh, Aron/A-7843-2008 | 36671796300; 56384544400; 57212627255; 12789803400; 35315151400 | a.walsh@imperial.ac.uk; | ACS ENERGY LETTERS | ACS ENERGY LETT | 2380-8195 | 5 | 7 | SCIE | CHEMISTRY, PHYSICAL;ELECTROCHEMISTRY;ENERGY & FUELS;MATERIALS SCIENCE, MULTIDISCIPLINARY;NANOSCIENCE & NANOTECHNOLOGY | 2020 | 23.101 | 3.3 | 0.86 | 2025-06-25 | 15 | 15 | Perovskite; Stacking faults; Corner sharing; Halide perovskites; Hexagonal stacking; Hole blocking layers; Nano domain; Performance bottlenecks; Polytypes; Lead compounds | English | 2020 | 2020-07-10 | 10.1021/acsenergylett.0c01124 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | |||||
| ○ | ○ | Article | Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities | Background Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signaling pathway. This aggravates hypoxia within the tumor core and ultimately leads to increased tumor proliferation and metastasis. To overcome this limitation, we developed nanoparticles with antiseptic activity that target tumor vascular abnormalities. Methods Ferritin-based protein C nanoparticles (PCNs), known as TFG and TFMG, were generated and tested in Lewis lung carcinoma (LLC) allograft and MMTV-PyMT spontaneous breast cancer models. Immunohistochemical analysis was performed on tumor samples to evaluate the tumor vasculature. Western blot and permeability assays were used to explore the role and mechanism of the antitumor effects of PCNs in vivo. For knocking down proteins of interest, endothelial cells were transfected with siRNAs. Statistical analysis was performed using one-way ANOVA followed by post hoc Dunnett's multiple comparison test. Results PCNs significantly inhibited hypoxia and increased pericyte coverage, leading to the inhibition of tumor growth and metastasis, while increasing survival in LLC allograft and MMTV-PyMT spontaneous breast cancer models. The coadministration of cisplatin with PCNs induced a synergistic suppression of tumor growth by improving drug delivery as evidenced by increased blood prefusion and decreased vascular permeability. Moreover, PCNs altered the immune cell profiles within the tumor by increasing cytotoxic T cells and M1-like macrophages with antitumor activity. PCNs induced PAR-1/PAR-3 heterodimerization through EPCR occupation and PAR-1 activation, which resulted in G alpha 13-RhoA-mediated-Tie2 activation and stabilized vascular tight junctions via the Akt-FoxO3a signaling pathway. Conclusions Cancer treatment targeting the tumor vasculature by inducing antitumor immune responses and enhancing the delivery of a chemotherapeutic agent with PCNs resulted in tumor regression and may provide an effective therapeutic strategy. | Choi, Young Sun; Jang, Hyeonha; Gupta, Biki; Jeong, Ji-Hak; Ge, Yun; Yong, Chul Soon; Kim, Jong Oh; Bae, Jong-Sup; Song, Im-Sook; Kim, In-San; Lee, You Mie | BK21 Plus KNU MultiOm Creat Drug Res Team, Daegu, South Korea; Kyungpook Natl Univ, Coll Pharm, Dept Mol Pathophysiol, Vessel Organ Interact Res Ctr,VOICE MRC, Daegu 41566, South Korea; Natl Nanofab Ctr NNFC, Nanobio Applicat Team, 291 Daehak Ro, Daejeon 34141, South Korea; Kyungpook Natl Univ, Res Inst Pharmaceut Sci, Daegu, South Korea; Univ Pittsburgh, Dept Pathol, 200 Lothrop St, Pittsburgh, PA 15261 USA; Yeungnam Univ, Coll Pharm, Gyongsan 38541, South Korea; Korea Inst Sci & Technol, Biomed Res Inst, Seoul 02792, South Korea | ; Gupta, Biki/AAF-6859-2020; Bae, Jong-Sup/AAU-9724-2020; Lee, Kyung-Soo/C-9016-2011 | 57216647352; 57218761651; 56453847700; 55913671500; 57217852719; 7005701068; 57209837747; 16021543200; 7201564500; 34770432800; 8230508600 | lym@knu.ac.kr; | JOURNAL OF HEMATOLOGY & ONCOLOGY | J HEMATOL ONCOL | 1756-8722 | 13 | 1 | SCIE | HEMATOLOGY;ONCOLOGY | 2020 | 17.388 | 3.3 | 0.76 | 2025-06-25 | 22 | 22 | Antitumor immune response; EPCR; Ferritin-based protein C nanoparticles; Tie2; Vascular normalization | ENDOTHELIAL-BARRIER PROTECTION; TIE2 ACTIVATION; BLOOD-VESSELS; THROMBIN; CANCER; NORMALIZATION; ANGIOGENESIS; PERMEABILITY; MACROPHAGES; INHIBITION | Antitumor immune response; EPCR; Ferritin-based protein C nanoparticles; Tie2; Vascular normalization | Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Alkylating; Apoferritins; Bevacizumab; Carcinoma, Lewis Lung; Cell Hypoxia; Cisplatin; Coculture Techniques; Drug Delivery Systems; Drug Synergism; Endothelial Cells; Female; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles; Neoplasm Proteins; Neovascularization, Pathologic; Pericytes; Protein C; Receptor, TIE-2; Specific Pathogen-Free Organisms; Tumor Microenvironment; Vascular Remodeling; angiopoietin receptor; antineoplastic agent; cisplatin; ferritin; nanoparticle; protein C; protein C nanoparticle; proteinase activated receptor 1; proteinase activated receptor 3; small interfering RNA; transcription factor FKHRL1; unclassified drug; alkylating agent; angiogenesis inhibitor; angiopoietin receptor; apoferritin; bevacizumab; cisplatin; FTL protein, human; nanoparticle; protein C; Tek protein, mouse; tumor protein; adult; Akt signaling; allograft; animal cell; animal experiment; animal model; animal tissue; antimicrobial activity; antineoplastic activity; Article; blood vessel permeability; breast cancer; cancer inhibition; cancer model; cell hypoxia; controlled study; cytotoxic T lymphocyte; drug distribution; drug mechanism; drug response; drug stability; endothelium cell; female; gene knockdown; heterodimerization; human; human cell; immunohistochemistry; in vivo study; Lewis carcinoma; macrophage; male; metastasis; metastasis inhibition; mouse; nonhuman; pericyte; tight junction; tumor growth; tumor vascularization; vascular remodeling; Western blotting; animal; C57BL mouse; coculture; drug delivery system; drug effect; drug potentiation; experimental mammary neoplasm; germfree animal; immunology; metabolism; neovascularization (pathology); pathology; physiology; transgenic mouse; tumor microenvironment; vascular remodeling; vascularization | English | 2020 | 2020-09-14 | 10.1186/s13045-020-00952-9 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Certificateless-Signcryption-Based Three-Factor User Access Control Scheme for IoT Environment | User access control is a crucial requirement in any Internet of Things (IoT) deployment, as it allows one to provide authorization, authentication, and revocation of a registered legitimate user to access real-time information and/or service directly from the IoT devices. To complement the existing literature, we design a new three-factor certificateless-signcryption-based user access control for the IoT environment (CSUAC-IoT). Specifically, in our scheme, a user U's password, personal biometrics, and mobile device are used as the three authentication factors. By executing the login and access control phase of CSUAC-IoT, a registered user (U) and a designated smart device (Si) can authorize and authenticate mutually via the trusted gateway node (GN) in a particular cell of the IoT environment. In our setting, the environment is partitioned into disjoint cells, and each cell will contain a certain number of IoT devices along with a GN. With the established session key between U and Si, both entities can then communicate securely. In addition, CSUAC-IoT supports new IoT devices deployment, user revocation, and password/biometric update functionality features. We prove the security of CSUAC-IoT under the real-or-random (ROR) model, and demonstrate that it can resist several common attacks found in a typical IoT environment using the AVISPA tool. A comparative analysis also reveals that CSUAC-IoT achieves better tradeoff for security and functionality, and computational and communication costs, in comparison to five other competing approaches. | Mandal, Shobhan; Bera, Basudeb; Sutrala, Anil Kumar; Das, Ashok Kumar; Choo, Kim-Kwang Raymond; Park, Youngho | Int Inst Informat Technol, Ctr Secur Theory & Algorithm Res, Hyderabad 500032, India; Huawei Technol, Bengaluru, India; CA Technol, Hyderabad 500032, India; Univ Texas San Antonio, Dept Informat Syst & Cyber Secur, San Antonio, TX 78249 USA; Kyungpook Natl Univ, Sch Elect Engn, Daegu 41566, South Korea | ; Bera, Basudeb/ACC-6233-2022; Das, Ashok Kumar/U-2790-2019; Choo, Kim-Kwang Raymond/A-3634-2009 | 57224732544; 57214777647; 57148305900; 55450732800; 57208540261; 56962990300 | shobhan.mandal@students.iiit.ac.in;basudeb.bera@research.iiit.ac.in;anilkumarsutrala@gmail.com;iitkgp.akdas@gmail.com;raymond.choo@fulbrightmail.org;parkyh@knu.ac.kr; | IEEE INTERNET OF THINGS JOURNAL | IEEE INTERNET THINGS | 2327-4662 | 7 | 4 | SCIE | COMPUTER SCIENCE, INFORMATION SYSTEMS;ENGINEERING, ELECTRICAL & ELECTRONIC;TELECOMMUNICATIONS | 2020 | 9.471 | 3.4 | 6.44 | 2025-06-25 | 96 | 121 | Automated validation of Internet security protocols and application (AVISPA); Internet of Things (IoT); key agreement; security; signcryption; user access control | KEY EXCHANGE; AUTHENTICATION PROTOCOL; INDUSTRIAL INTERNET; SECURITY; BIOMETRICS; PRIVACY | Automated validation of Internet security protocols and application (AVISPA); Internet of Things (IoT); key agreement; security; signcryption; user access control | Authentication; Cryptography; Gateways (computer networks); Certificateless signcryption; Communication cost; Comparative analysis; Internet of Things (IOT); Legitimate users; Real-time information; User access control; User revocation; Internet of things | English | 2020 | 2020-04 | 10.1109/jiot.2020.2966242 | 바로가기 | 바로가기 | 바로가기 | 바로가기 | ||
| ○ | ○ | Article | Clinicopathologic risk factors of radioactive iodine therapy based on response assessment in patients with differentiated thyroid cancer: a multicenter retrospective cohort study | Purpose We investigated whether predictive clinicopathologic factors can be affected by different response criteria and how the clinical usefulness of radioactive iodine (RAI) therapy should be evaluated considering variable factors in patients with differentiated thyroid carcinoma (DTC). Methods A total of 1563 patients with DTC who underwent first RAI therapy after total or near total thyroidectomy were retrospectively enrolled from 25 hospitals. Response to therapy was evaluated with two different protocols based on combination of biochemical and imaging studies: (1) serum thyroglobulin (Tg) and neck ultrasonography (US) and (2) serum Tg, neck US, and radioiodine scan. The responses to therapy were classified into excellent and non-excellent or acceptable and non-acceptable to minimize the effect of non-specific imaging findings. We investigated which factors were associated with response to therapy depending on the follow-up protocols as well as response classifications. Multivariate logistic regression analysis was performed to identify factors significantly predicting response to therapy. Results The proportion of patients in the excellent response group significantly decreased from 76.5 to 59.6% when radioiodine scan was added to the follow-up protocol (P < 0.001). Preparation method (recombinant human TSH vs. thyroid hormone withdrawal) was a significant factor for excellent response prediction evaluated with radioiodine scan (OR 2.129; 95% CI 1.687-2.685; P < 0.001) but was not for other types of response classifications. Administered RAI activity, which was classified as low (1.11 GBq) or high (3.7 GBq or higher), significantly predicted both excellent and acceptable responses regardless of the follow-up protocol. Conclusions The clinical impact of factors related to response prediction differed depending on the follow-up protocol or classification of response criteria. A high administered activity of RAI was a significant factor predicting a favorable response to therapy regardless of the follow-up protocol or classification of response criteria. | Kwon, Seong Young; Lee, Sang-Woo; Kong, Eun Jung; Kim, Keunyoung; Kim, Byung Il; Kim, Jahae; Kim, Heeyoung; Park, Seol Hoon; Park, Jisun; Park, Hye Lim; Oh, So Won; Won, Kyoung Sook; Ryu, Young Hoon; Yoon, Joon-Kee; Lee, Soo Jin; Lee, Jong Jin; Chong, Ari; Jeong, Young Jin; Jeong, Ju Hye; Cho, Young Seok; Cho, Arthur; Cheon, Gi Jeong; Choi, Eun Kyoung; Hwang, Jae Pil; Bae, Sang Kyun | Chonnam Natl Univ, Med Sch, Dept Nucl Med, Hwasun, Jeonnam, South Korea; Hwasun Hosp, Hwasun, Jeonnam, South Korea; Kyungpook Natl Univ, Sch Med, Dept Nucl Med, Daegu, South Korea; Kyungpook Natl Univ, Chilgok Hosp, Daegu, South Korea; Yeungnam Univ, Med Sch & Hosp, Dept Nucl Med, Daegu, South Korea; Pusan Natl Univ, Dept Nucl Med, Busan, South Korea; Pusan Natl Univ, Biomed Res Inst, Busan, South Korea; Korea Inst Radiol & Med Sci, Dept Nucl Med, Seoul, South Korea; Chonnam Natl Univ Hosp, Dept Nucl Med, Gwangju, South Korea; Kosin Univ, Gospel Hosp, Dept Nucl Med, Busan, South Korea; Univ Ulsan, Coll Med, Ulsan Univ Hosp, Dept Nucl Med, Ulsan, South Korea; Inje Univ, Busan Paik Hosp, Dept Nucl Med, Busan, South Korea; Catholic Univ Korea, Coll Med, Seoul St Marys Hosp, Div Nucl Med,Dept Radiol, Seoul, South Korea; Seoul Natl Univ, Boramae Med Ctr, Dept Nucl Med, Seoul, South Korea; Keimyung Univ, Dongsan Hosp, Dept Nucl Med, Daegu, South Korea; Yonsei Univ, Gangnam Severance Hosp, Dept Nucl Med, Seoul, South Korea; Ajou Univ, Sch Med, Dept Nucl Med & Mol Imaging, Suwon, South Korea; Hanyang Univ, Med Ctr, Dept Nucl Med, Seoul, South Korea; Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul, South Korea; Chosun Univ Hosp, Dept Nucl Med, Gwangju, South Korea; Dong A Univ Hosp, Dept Nucl Med, Busan, South Korea; Kyungpook Natl Univ Hosp, Dept Nucl Med, Daegu, South Korea; Samsung Med Ctr, Dept Nucl Med, Seoul, South Korea; Yonsei Univ, Coll Med, Dept Nucl Med, Seoul, South Korea; Seoul Natl Univ, Coll Med, Dept Nucl Med, Seoul, South Korea; Catholic Univ Korea, Coll Med, Incheon St Marys Hosp, Div Nucl Med,Dept Radiol, Seoul, South Korea; Soon Chun Hyang Univ, Bucheon Hosp, Dept Nucl Med, Bucheon, South Korea; Inje Univ, Haeundae Paik Hosp, Dept Nucl Med, Busan, South Korea | Kim, Dong/I-7600-2015; Cho, Young-Seok/J-5670-2012; Kim, Min Chul/IYJ-9897-2023; Cheon, Gi/AAA-5702-2020; Kwon, Seong-Young/AAU-3101-2021; LEE, KYUNG-HAN/HPD-9299-2023; Kim, Dae-Hyun/AAA-4463-2020; Cheon, Gi Jeong/G-6064-2018 | 40261965600; 57196249819; 37007708500; 36523010700; 56984269500; 37074783400; 57225124881; 37075543400; 56925704100; 57717247700; 36154944900; 7005951440; 7103412060; 7403587745; 57253783600; 36997966500; 26533830900; 35722001300; 55701537800; 56595898700; 12765492600; 7003953937; 57202446605; 55351899700; 37051724000 | sbae@inje.ac.kr; | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | EUR J NUCL MED MOL I | 1619-7070 | 1619-7089 | 47 | 3 | SCIE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | 2020 | 9.236 | 3.4 | 0.95 | 2025-06-25 | 16 | 16 | Differentiated thyroid carcinoma; Radioactive iodine therapy; Recombinant human thyrotropin; Response to therapy | ASSOCIATION MANAGEMENT GUIDELINES; RADIOIODINE REMNANT ABLATION; ADULT PATIENTS; PAPILLARY; SURVIVAL; NODULES | Differentiated thyroid carcinoma; Radioactive iodine therapy; Recombinant human thyrotropin; Response to therapy | Humans; Iodine Radioisotopes; Retrospective Studies; Risk Factors; Thyroglobulin; Thyroid Neoplasms; Thyroidectomy; iodine 123; radioactive iodine; thyroglobulin; thyroid hormone; thyrotropin; radioactive iodine; thyroglobulin; adult; age; aged; Article; cancer radiotherapy; cancer staging; carcinogenesis; clinical effectiveness; clinical feature; cohort analysis; comparative effectiveness; descriptive research; differentiated thyroid cancer; disease free interval; disease specific survival; echography; female; human; low iodine diet; major clinical study; male; multicenter study; near total thyroidectomy; predictive value; quantitative analysis; radiation dose; response evaluation criteria in solid tumors; retrospective study; risk factor; sex; thyroidectomy; tumor volume; whole body scintiscanning; clinical trial; diagnostic imaging; risk factor; thyroid tumor | English | 2020 | 2020-03 | 10.1007/s00259-019-04634-8 | 바로가기 | 바로가기 | 바로가기 | 바로가기 |
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